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John Fetterman, Marjorie Taylor Greene will headline TribFest
Two of American politics’ most unique and least predictable voices bookend our three days of live journalism.
Dolly Parton remembered in new 28-page tribute comic book
The country music superstar, entrepreneur and philanthropist died Aug. 25
Favored Farmhouse expands business
MOSES LAKE — The owners of the Favored Farmhouse celebrated expanding their business by cutting the ribbon for the new drive-through Thursday – and co-owner Daphne Martinez said there’s more to come.
This Founder Built a $220 Million Fitness Business. His Playbook Comes Down to 4 Decisions
Tony Hartl has grown Undefeated Tribe, his master franchise for Crunch Fitness, to 4,000 employees and systemwide revenues of $220 million. Here's how.
Inside Sergey Brin's growing influence over Google Gemini
Google's AI reshuffle has handed more sway to Sergey Brin, say insiders, who describe an effective operator trying to run Gemini like a startup.
New outpatient clinic focused on suicide prevention opens in Burlington
University of Vermont Health held an open house last week to celebrate the opening of the Asha Clinic, which it describes as the only program in the region focused exclusively on suicide care. The clinic's work is led by Craig Bryan, an expert in suicide treatment and research.
Did New Film Unit Just Shift AMC Stock’s Investment Narrative?
AMC Entertainment Holdings recently launched Leawood Films, a film distribution unit based in Los Angeles and Leawood, Kansas, aiming to bring more small and mid-sized movies into theatres worldwide while relying on fully financed projects to limit production risk. The new distributor uses AMC’s excess screen capacity and past concert-film marketing experience to secure theatrical placement for filmmakers who might otherwise struggle to find backing, while leaving most downstream revenue and...
Chubb names digital distribution chief for small commercial
Jennifer Burnham will lead Marketplace and API channel expansion for independent agents
Why a shorter eating window may not mean better metabolic health
In a nationally representative cross-sectional study of 16,973 Korean adults, researchers identified three distinct eating patterns based on the timing and distribution of daily energy intake. Eating later within a shorter daily window was associated with higher odds of metabolic syndrome, elevated blood pressure, triglycerides, and fasting glucose, while frequent grazing showed a mixed metabolic profile.
Allegheny County Council proposes bill that could regulate AI use in political campaign materials
Members of Allegheny County Council on Tuesday introduced a bill that would require political candidates to disclose their use of artificial intelligence in campaign materials, an effort aimed at preventing voters from being misled by AI-generative content. If passed, the ordinance would establish disclosure requirements for AI-generated campaign content used
Detmers adds to torrid stretch in Angels win
Left-hander Reid Detmers tossed six scoreless innings, striking out nine, to extend his impressive stretch since the All-Star break.
Marlins' Brian Navarreto Finding Value Beyond Bat
Miami’s veteran backstop has endured a difficult offensive year while continuing to provide the Marlins with dependable work behind the plate and timely contributions.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Michigan rabbis lay out demands for El-Sayed and state Democrats to earn their votes
As the candidate seeks Jewish voters, an open letter describes Jewish sovereignty in Israel and Jewish safety as “nonnegotiables.”
Tribal consortium achieves long-desired ownership of Alaska Native Medical Center
The nation’s biggest tribal health organization now owns the Anchorage hospital it has long operated.
Three-time MVP Aaron Judge returns to Yankees
BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]
Aryna Sabalenka Shuts Down Reporter Over U.S. Open Party Question
The World No. 1 pushed back after a reporter described her pre-tournament week as 'lots of parties and fun.'
Colts Part Ways With 29-Game Starter
Jaylon Jones did well to turn himself from a seventh-round pick into a consistent contributor the Indianapolis Colts. Those contributions didn’t end up being big enough, though. The Colts waived Jones on Tuesday. It was part of a three-pronged roster move that the Colts announced in an official press release like this: “The Indianapolis Colts […] The post Colts Part Ways With 29-Game Starter appeared first on HEAVY.
Local businesses brace for gigantic cargo moves starting next week
Locals anxiously waiting for superloads of heavy equipment — weighing up to 380 tons — to travel through their towns will have to hold on until next week. The first trip, on a giant, specialized truck, is expected to leave a dock in Gilpin’s Schenley section on Monday morning. Officials
Southern Union names Pike dean of health sciences
CONTRIBUTED BY SUSCC OPELIKA — Southern Union State Community College has named Dr. Richard Pike as dean of health sciences. Pike assumed the position Sept. 1 following the retirement of Dean Rhonda Davis. A graduate of Southern Union, Pike earned an associate in science degree and his emergency medical technician certification from the college. He […]
Ohio politicians keep promise to rebuke Les Wexner by donating $200K in campaign contributions
Freedom a la Cart, a downtown Columbus cafe that employs sex trafficking survivors, was one of several organizations that politicians donated to this year.
Senate Set to Vote to Begin Debate on Protect College Sports Act
Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
Crossland Construction Lab opens at Bentonville High School
Area schools are working with construction companies to introduce students to industry jobs through construction programs as demand for workers rises. A construction company executive hopes the programs will lead...
Catch 22: Californians can't afford health insurance but face fines if they drop it
For one Californian, the state subsidy contributed $1 a month to her $600 premium. She considered dropping coverage but faced a $1,600 penalty.
The Villages Health’s $541 million settlement highlights the cost of ‘upcoding’
The settlement describes how The Villages Health would go back into patients' medical files months later and add diagnoses -- sometimes adding in monitoring, evaluations or treatments.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
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New Mexico tribe and pueblos wrap up case that Kalshi sports betting hurts their sovereignty
The New Mexico plaintiffs' filing cites a new appeals court ruling restoring state regulators' oversight of the prediction market.
Meet Rachel Chen, the 18-year-old Los Angeles student who expanded a 1997 quantum-math idea to describe entire particle systems with simple diagrams; she won $100,000
At just 18, Rachel Chen has taken a decades-old mathematical idea and expanded it into a visual framework for understanding complex quantum systems, earning her a $100,000 award in the 2026 Regeneron Science Talent Search.
G.A. Carmichael Family Health Center ribbon cutting set for Wed., Sept. 9
GOODMAN, MS — G.A. Carmichael Family Health Center is proud to announce the grand opening and ribbon cutting of the G.A. Carmichael Community Student Health Center at Holmes Community College…
Booster group pushes to keep Downtown Pittsburgh businesses viable
The Pittsburgh Downtown Partnership has sought to bring more small businesses into the Golden Triangle in recent years — and now it’s launching a concerted effort to keep them there. Dubbed Business Boost, the initiative is meant to support small businesses and ensure they can last Downtown long-term, Pittsburgh Downtown
Next Apple TV's Chip Revealed in Latest Leak
The next Apple TV 4K will be equipped with an A19 or A19 Pro chip, according to evidence in Apple's code uncovered by MacRumors contributor Aaron Perris. In particular, the device's model identifier points towards the A19 generation of chips. Accordingly, the next Apple TV would have 8GB or 12GB of RAM, up from 4GB in the current 2022 model with the A15 Bionic chip.
TST Best Bets: September 8, 2026
The Los Angeles Angels dropped the series opener yesterday, 5-2, against the Boston Red Sox.
Fernandes receives second Ballon d'Or nomination
Manchester United and Portugal attacking midfielder Bruno Fernandes has been named in the 30-player shortlist for the 2026 Ballon d'Or. The 32-year-old made 37 appearances across all competitions last season, scoring nine goals and contributing 22 assists, as Manchester United secured Champions League football for 2026-27.
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
Heat linked to reunion with struggling ex-Lakers point guard
An NBA writer believes the Miami Heat should consider bringing back a former Los Angeles Lakers backcourt contributor for a second stint.
“The View” pays powerful tribute to Barbara Walters in emotional season 30 premiere: ‘This is that show’ she envisioned
Whoopi Goldberg spoke about how each of the six current cohosts fulfills the late Walters’ desire to highlight the perspectives of an eclectic group of women.
Scotland defender Souttar may leave Rangers soon
John Souttar may yet leave Rangers in the short term, even though the transfer window has closed in Scotland. The Scotland defender, 29, is under contract until next summer. "I think he still can [make a contribution]," said Rangers manager Derek McInnes.
William Shatner reveals truth behind 'Star Trek' Tribbles scene, sliding doors
LOS ANGELES ― While still helming the U.S.S. Enterprise as rugged Captain James T.
Haaland receives sixth Ballon d'Or nomination
Manchester City and Norway striker Erling Haaland has been named in the 30-player shortlist for the 2026 Ballon d'Or. The 26-year-old made 52 appearances across all competitions last season, scoring 38 goals and contributing nine assists, as Manchester City lifted the FA Cup and Carabao Cup. Haaland's new team-mate Ayyoub Bouaddi has also been nominated for the Men's Young Talent of the Year award.
Is Cardinal Health Building a New Tech-Enabled Healthcare Platform?
Technology is becoming a bigger part of CAH's strategy, linking distribution, specialty services and logistics through digital workflows.
Best Bets: A quick guide to La Jolla entertainment and experiences
Local events and activities
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
How Is Hilton Worldwide's Stock Performance Compared to Other Leisure and Entertainment Stocks?
Hilton Worldwide has outperformed the Leisure and Entertainment industry over the past year, and analysts are cautiously optimistic about the stock’s prospects.
U.S. Senator Reed discuses efforts to reverse Trump administration's cuts to health care
U.S. Senator Jack Reed is set to discuss the effort to reverse the Trump administration’s cuts to the nation’s health care system.He will discuss these on Tuesd
Israel's Problems of Governance: Perennial Causes and Political Context
Essays – The State of Israel is not often associated with the persistent problems of governance that have beset many of its neighbors over the years. With a
Xiaohong Chen named the Koopmans Professor of Economics
Chen, who has made fundamental contributions to econometric methods, joined the Yale faculty in 2007.
First Renderings Of New Philadelphia Arena Inspired By The Spectrum
Planned 2030 opening includes an outdoor plaza and opportunities for an expanded restaurant experience at the South Philadelphia location
Former employees accuse Family Health Centers of San Diego of understaffing, retaliation
Former employees take issue with how much cash the health system is sitting on while they say clinics are understaffed. The network has netted $58 million to $80 million each year since 2020, its tax filings show.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Broncos New Running Back Looks Like A Sean Payton Special
The Denver Broncos drafted Jonah Coleman in the fourth round, and he could be a surprising contributor.
MDI Health to Honor Mount Desert Nursing Association with 2026 Impact Award
BAR HARBOR—MDI Health will honor Mount Desert Nursing Association (MDNA) as its 2026 Community Partner of the Year during the organization’s Annual Meeting and Community Celebration on Tuesday, September 15. MDNA will receive the 2026 Impact Award in recognition of its longstanding commitment to providing in-home nursing, physical and occupational therapy, and medical equipment to the Island region. By caring for people where they live, MDNA helps patients remain safely and independently at home, providing reassurance and support to their families. “Mount Desert Nursing Association exemplifies the power of community partnership,” said Chrissi Maguire, President and CEO of MDI Health. “Its nurses bring skilled, compassionate care directly into people’s homes, helping patients navigate illness, recovery, and some of life’s most difficult moments. We are deeply grateful for MDNA’s service and the important role it plays in the health of our community.” MDNA works closely with MDI Health providers and care teams to support continuity of care following hospitalization, surgery, illness, or changes in health. Its personalized services extend care beyond the hospital and help ensure patients receive the support they need close to home. “For 77 years, MDNA has been here for our community, helping our neighbors recover and remain safely at home. Our long-standing partnership with MDI Health is an important part of making that possible. Together, we help ensure a seamless transition from hospital to home and provide patients with the continued care they need. We are incredibly grateful for this recognition and especially proud of our talented and hardworking team,” said Amy McVety, Executive Director of Mount Desert Nursing Association. The Impact Award will be presented during MDI Health’s Community Celebration from 5 to 7 p.m. at the Bar Harbor Club. The event will also recognize outstanding employees, volunteers, and trustees; celebrate MDI Health’s achievements over the past year; and mark a transition in Board leadership as Madeleine Braun, PhD, MBA, prepares to succeed Martha Wagner, PhD, as chair. The celebration will feature music, refreshments, the MDI Health Auxiliary Raffle, and a cash bar. MDI Health’s Annual Business Meeting will take place from 3:30 to 4 p.m. via Zoom. These events are free and open to the public, but space is limited. To reserve your spot, contact Patrianna Anderson at 207-288-5082, ext. 1432, or visit mdihospital.org/communitycelebration. Subscribe Share Leave a comment
Letter: If Utah cares about mental health, it won’t cut Medicaid funds
Letter: If Utah cares about mental health, it won’t cut Medicaid funds
6 Impact Training Exercises to Boost Bone Strength, From an Orthopedic Surgeon
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Dynamic Creatures Launches Interactive Character Robots for Hospitality & Entertainment
Dynamic Creatures, founded by ex-Boston Dynamics leaders, unveils a new category of mobile, interactive character robots for the hospitality and entertainment industries.
NC State a 30.5-point favorite against Richmond
It’s about time for NC State to get on with the rest of its season, and thank goodness for that, since having to sit on a terrible performance for two weeks is pretty unpleasant, it turns out. I’m sure the Pack is more than ready to get back on the field. The task will be […]
Dodgers Owner’s MAGA Stance Leaves Los Angeles Advocate ‘Very’ Disappointed
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Minnesota business leaders are captivated by this philanthropy manual
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15 years of our home! Celebrate on Juventus Play
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Parkland study could change how hospitals treat a leading cause of maternal, infant mortality
A Parkland Health study could help address a common but life-threatening pregnancy complication. Researchers found universally prescribed aspirin led to a significant decrease in severe preeclampsia — one of the leading causes of infant and maternal mortality in the U.S. and globally.
GOP’s Trump-led midterm convention comes to Dallas this week
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Washington: Despite fueling AI’s wrong answers, data centers are uniting Dems and the GOP
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The Market Forces Quietly Adding Thousands to Patient Bills
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Ribbon Bio Appoints Jay Therrien as Chief Business Officer
Cell-free DNA assembly pioneer, Ribbon Bio, has today announced the appointment of Jay Therrien as Chief Business Officer. Therrien joins Ribbon's executive leadership team where he will lead the company's commercial strategy and growth initiatives.
All known life uses 4 DNA letters; UC San Diego showed an existing bacterial enzyme can accurately read and transcribe 8, doubling the genetic alphabet with synthetic letters
All life on Earth, from bacteria to blue whales, writes its genetic instructions using the same four-letter alphabet. These four DNA bases, usually referred to as A, T, C and G, pair up in predictable ways to store and pass on the information needed for life.
Adventist Health Launches Epic System with Expanded AI Integration
ROSEVILLE, CA — Adventist Health has announced that they have completed the largest technology implementation in its history, connecting all 27 hospitals and more than 440 clinics across California, Oregon, and Hawaii through a single electronic health record system. The health system went live with Epic on August 30, marking what Adventist Health describes as […]
Kerry Yu Achieves Recognition for Expertise and Contributions to the Field of Fashion, Modeling, and Entertainment Production
September 8, 2026 -- Kerry Yu recognized for 30 years in fashion design and apparel management
Theresa Porcaro Celebrated for Leadership in Healthcare Marketing and Women's Health Advocacy
September 8, 2026 -- Theresa Marie Porcaro is lauded for her contributions as a leading executive at Pelvic Rehabilitation Medicine
James Alan Cook Celebrated for Success and Expertise in Law and Interactive Entertainment
September 8, 2026 -- James Alan Cook is noted for his legal career in computer law and interactive entertainment
David Andrew Goodman is Celebrated for Decades of Continued Success in the Entertainment Sector
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‘Collectively it’s been terrible’: Gonzales businesses report major losses amid construction
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Navy Medicine Advances Operational Health IT for Distributed Maritime Operations
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Politicians describe moments they detained man who rushed Amy Acton at Canfield Fair
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Rebels responded the way Mullen hoped they would
UNLV got better in virtually every area in its second game and is now 1-1 after the 21-6 win over Hawaii.
Port of Grandview works to attract new businesses with active marketing and land development
The BriefThe Port of Grandview is actively marketing the community to attract new business development, with efforts including attendance at trade shows and conventions like Food Northwest in Portland.The Port reports strong demand for business property, with several prospective clients currently seeking space to build in Grandview.The Port recently acquired 45 acres for its new Woodworth Road Business Park, with planning underway to support the community's continued growth.GRANDVIEW — The Port of Grandview is capitalizing on strong interest in the community by actively marketing Grandview to businesses seeking locations for expansion and growth. The Port's efforts are paying off, with increased development activity and growing demand for available business property.Grandview's appeal stems from multiple factors. The community's available land and central location between the Tri-Cities and Yakima make it an attractive option for businesses looking to establish or expand operations. The Port has recognized these advantages and is taking a proactive approach to market the community directly to potential clients.Port Executive Director Randy Tucker says the Port has been actively attending trade shows and conventions to promote Grandview as a business destination. These events, including Food Northwest in Portland, provide opportunities to connect with companies actively seeking new locations."Say, hey, locate your business here and bring your customers here. And it's worked out pretty good for us," Tucker said.The Port's marketing strategy is generating results. The Port reports strong demand for business property, with several prospective clients currently looking for space to build in Grandview. This interest reflects the effectiveness of the Port's outreach efforts and the community's appeal to businesses in various industries.To support this growth, the Port recently acquired 45 acres for its new Woodworth Road Business Park. Planning is underway to determine how the property can best support Grandview's continued development and attract additional businesses to the area.The combination of available land, strategic location, and active marketing positions Grandview as an increasingly attractive option for businesses seeking to relocate or expand. As the Port continues its efforts to promote the community, Grandview appears poised for continued economic growth and development. News Three Queens Fire approaching 10,000 acres, now 11% contained Robert Desaulniers, Josh Culbreth News Two injured after rear-end crash leads to rollover near Grandview Robert Desaulniers News Grandview High School temporarily enters secure and teach for possible altercation between students Robert Desaulniers News Port of Grandview pursues economic growth with new business park development William Albert, Apple Valley News Now News Driver dies in fiery crash in Columbia Park Friday Erin Wencl COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Nearly 1.7 million deaths linked to second-hand smoke in 2023, study finds
More than 2.7 billion people worldwide, including 767 million children, were exposed to second-hand smoke in 2023, contributing to nearly 1.7 million deaths, a Lancet study said on Tuesday. Researchers…
John Williams, 94, Surprises Hollywood Bowl Crowd by Conducting ‘Imperial March’
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‘We’re healthy’: Mike McCarthy says Steelers have clean bill of health headed into opener
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I feel 100% fit now, says Nunes
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Dallas Cowboys All-Pro Tyler Smith gets devastating injury update
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An eternal chapter closed: Reflecting on Lionel Messi’s Argentina retirement
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Follow U-T business reporter in S. Korea as he navigates digital kiosks, gets a style makeover, finds a San Diego connection
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Notre Dame football vs. Rice | How to watch, listen, odds
Here are things to know about Notre Dame football vs. Rice on Saturday, Sept. 12. How to watch, listen and odds.
Injured UGA RB provides update on his health after offseason accident
Dante Dowdell shared that he suffered a punctured lung, broken ribs, nerve damage to his right arm and broke both collarbones. He also had nine staples in his head.
Manta to Distribute Manga from KADOKAWA and Square Enix Globally
SEOUL, South Korea--(BUSINESS WIRE)--Sep 7, 2026--
Science says ancient roman concrete could repair its own cracks: The secret was hidden in tiny white chunk
Modern concrete can become vulnerable when cracks allow water and chemicals to seep into its interior. Ancient Roman concrete, by contrast, appears to have contained a reserve of reactive, calcium-rich material that could contribute to its long-term durability.
With $100 worth of supplies, this Chula Vista teen just won a prestigious international science award
Ihan Sung, 17, won fourth place in the Regeneron International Science and Engineering Fair. Two other students from Eastlake High also competed.
Sherrill, State Employee Unions Reach Deal to Hold Health Benefit Contributions Steady in 2027
New Jersey state employees will not face an increase in their health benefit contribution rates in 2027 under an agreement announced by Gov. Mikie
Green light for Keaau Health Center: Commissioners OK $90M project
Green light for Keaau Health Center: Commissioners OK $90M project - Hawaii News | Hawaii Tribune-Herald
Scientists found 66-million-year-old wound still healing inside a T. rex’s rib
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“Fascinating game” Arteta proud of his players’ performance against Chelsea
Mikel Arteta is proud of his Arsenal players after they came back from a goal down to beat Chelsea in the Premier League yesterday, describing the fixture as a game he thoroughly enjoyed.Chelsea opene...
Prof Elizabeth Streicher unravels the science behind drug-resistant TB
Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics delivered her inaugural lecture on Tuesday 1 September 2026. Her research focuses on the transmission and spread of Tuberculosis (TB). Knowing where TB transmission is happening can help to stop it from spreading. Prof Elizabeth Streicher of the Division of Molecular Biology and Human Genetics in the Faculty of Medicine and Health Sciences delivered her inaugural lecture on Tuesday 1 September 2026. The title of her lecture was Decoding tuberculosis: the evolution of technology, epidemiology and the Mycobacterium tuberculosis genome. Streicher explained to Corporate Communication and Marketing how molecular epidemiology (using genetic information to track how and why diseases spread through populations) has improved our understanding of where drug-resistant TB comes from, how it spreads and how drug resistance evolves within and between populations. Tell us more about your research and why you became interested in this specific field. Overall, our research group studies the genome (complete set of DNA instructions found in a cell) of Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB) disease. Various regions of the genome are interrogated to study different aspects of the disease. My main focus has been on the epidemiology of tuberculosis – how the bacteria’s genome changes over time and what this tells us about the transmission and spread of the disease. How would you describe the relevance of your work? If we understand how the bacteria that cause TB change and spread, it can assist in combating TB globally. How has molecular epidemiology helped improve our understanding of drug-resistant TB? Molecular epidemiology was very important in drug-resistant TB as it was originally believed that bacteria that become resistant to antibiotics would be less fit and not be able to transmit. But it was shown that they can transmit, and therefore have to be monitored to identify hotspots of transmission and outbreaks, etc. Can you tell us briefly about the spoligotyping technique and its advantages for studying drug-resistant TB? Spoligotyping (a molecular technique used to identify and track specific strains of TB bacteria) does not detect drug resistance, but since the technique is relatively quick to do, it can be very useful in real-time situations, e.g. to monitor outbreaks of drug resistance. Why are interrupting transmission chains and identifying genomic hotspots important for controlling the spread of TB? Knowing where TB transmission is happening can assist in allocating resources to those areas to stop future transmission and spread of TB. Higher education can be challenging. What keeps you motivated when things get tough? Students – how they are so passionate and dedicated to learning and contributing to research and society as a whole. What aspects of your work do you enjoy the most? Again, the students and colleagues! But also the fact that it is continuously changing and thereby we are learning and expanding our knowledge. In the end, I know that we contribute to a better society in our small way. Tell us something exciting about yourself that people would not expect. Even though I love hiking (day and multi-day hikes) and being outside, I really do not like camping! How do you spend your free time? I love hiking (wellbeing in nature) and like to watch most sports. ©Higher Education Media Services. Subscribe
What's happening in Pensacola? See what's new, what's next, in food, business, traffic
Check out our roundup of the new businesses, major ribbon cuttings, and upcoming projects that could impact your family, neighborhood and commute.
Ribfest returning to Dunbar with food and entertainment
Ribfest, one of the Charleston area’s best-known food festivals, will be Sept. 10-13 at Shawnee Park in Dunbar.
What events are happening in the South Bend area from Sept. 7 to 13?
From the Blueberry Festival to Murder at the Morris, here is your guide to South Bend events for Sept. 7 to 13.
Jamaica takes its case for reparations for Britain's role in slavery to King Charles III
Jamaica is pushing for Britain to pay reparations for the trans-Atlantic slave trade. On Monday, the Caribbean nation will petition King Charles III to refer questions about slavery and the U.K.'s...
Jamaica takes its case for reparations for Britain's role in slavery to King Charles III
Jamaica is pushing for Britain to pay reparations for the trans-Atlantic slave trade. On Monday, the Caribbean nation will petition King Charles III to refer questions about slavery and the U.K.'s...