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Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department
BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science
Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.
Data center boom sparks massive power line fights hundreds of miles away
In Cat Kemmerling’s dream, she and her husband Rob are sitting in their pickup truck on a cliff on their West Virginia farm, overlooking the Shenandoah River. The truck is falling backwards over the edge, into the abyss below.
How the conservative Supreme Court has rewritten the rules for the midterms
Voters will pick the winners of next month’s midterm elections, but it is the conservative Supreme Court that has set the rules.
John Sununu is running on his family’s legacy in New Hampshire. His brother is staying on the sidelines
The campaign signs across New Hampshire read “Sununu” in block letters.
Trick-or-treaters descend on Callow Avenue for Calloween
Photos from Charleston Business District's annual Calloween event on Saturday, Oct. 24. ·
In Texas Senate Race, Talarico Leans Into Growing Rivalry With Elon Musk
On the trail, James Talarico, the Democratic Senate nominee, has increasingly gone after Mr. Musk, a critic of his who has given big to a group aligned with the Republican candidate, Ken Paxton.
AI coding agents hijacked using AGENTS.md file in Downloads folder
Researchers found a malicious AGENTS markdown instruction file in a customer's Downloads folder that tricked an AI coding agent into installing a rogue npm package.
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Jennifer Hawks explains why she should be California's State Treasurer
Jennifer Hawks, a candidate for California state treasurer, shared her qualifications and vision for the office in an interview on California Politics 360.
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones
Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
Florida political leaders mourn after shooting at FAMU homecoming
Florida politicians express grief after a shooting near FAMU homecoming festivities injured multiple people.
Three Days Grace in San Antonio: What to know
The Canadian rockers are bringing their Alienation Tour to town. Here are the details on tickets, parking and more.
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known
A "thick and peculiar" cephalopod.
GO Health asks families to be lead-aware
BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.
Campbell County health and food inspections (10/16/26–10/22/26)
GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]
Laramie County health and food inspections (10/16/26–10/22/26)
CHEYENNE, Wyo. — The Cheyenne-Laramie County Health Department inspects restaurants, bars, convenience stores, delis, grocery stores, bed and breakfasts
Natrona County health and food inspections (10/16/26–10/22/26)
CASPER, Wyo. — The Casper-Natrona County Health Department inspects restaurants, grocery stores, convenience stores, mobile food units, commissaries and
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
AI-generated video heats up suburban Texas political clash
Fort Bend County has seen plenty of controversy at its highest levels.
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
Modders Unlock GeForce RTX 20, 30 And 40 GPUs For Up To 2X Compute Gains
The compute barrierbbetween NVIDIA RTX Pro GPUs and NVIDIA GeForce GPUs has finally been breached.
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list
Aaron Rodgers now sits third all-time in passing touchdowns.
October 7 should have changed Israeli politics, yet we are voting for the same leaders
Israel deserves more than another election between yesterday’s failures. It deserves a new beginning.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
PS5 Answers 'Bleakest' Month with a 22% Upswing in Sales
How much does the enthusiast discourse matter?
Some Thoughts About Ron Duguay
Dear, departed Ron Duguay was not anything like his playboy image.
Oprah on the Health Metric We Should All Be Tracking
“These facts are a wakeup call for all of us to get serious about our heart health.”
Roots music fest fun in downtown Yadkinville
Click here to view this article from yadkinripple.com.
Stop Chasing Views: How 87% of Creators Are Using AI to Build Real Businesses Beyond Social Media
87% of creators say AI is growing their business. Here's how creators trade social media algorithms for owned commerce and real enterprises.
Nuthatches are rude: Ornithological observations from a recliner
I don’t know what age you’re supposed to start sitting in a recliner and looking out the living room window at the bird feeder, but I sure do like doing
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
New Instagam app on Apple TV brings reels, long-form video and live shows
Meta just made it easier to doomscroll from the comfort of your couch.
Trump touts U.S. oil business making ‘hundreds of billions’
President Trump tells rallygoers in Georgia that the United States’ oil and gas business is making “hundreds of billions of dollars because of what’s happened in the Middle East,” and predicts that prices at the pump will “come way down.”
Argument over purchase turns physical; suspect pulls gun at South Side business
KABB Fox News 29 San Antonio provides local news, weather forecasts, traffic updates, investigations, notices of events and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Bandera, Boerne, Carrizo Springs, Castroville, Cibolo, Converse, Crystal City, Cuero, Del Rio, Devine, Eagle Pass, Floresville, Fredericksburg, Goliad, Helotes, Hondo, Kerrville, Live Oak, New Braunfels, Pearsall, Pleasanton, Poteet, Poth, Sabinal, San Marcos, Seguin, Schertz, Somerset, Universal City, Uvalde, Windcrest.
Argument over purchase turns physical; suspect pulls gun at South Side business
WOAI NBC News Channel 4 San Antonio provides local news, weather forecasts, traffic updates, investigations, and items of interest in the community, sports and entertainment programming for San Antonio and nearby towns and communities in South Central Texas, including Windcrest, Uvalde, Universal City, Somerset, Seguin, Schertz, San Marcos, Sabinal, Poth, Poteet, Pleasanton, Pearsall, New Braunfels, Live Oak, Kerrville, Hondo, Helotes, Goliad, Fredericksburg, Floresville, Eagle Pass, Devine, Del Rio, Cuero, Crystal City, Converse, Cibolo, Castroville, Carrizo Springs, Boerne, Bandera.
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
Will there be VAR for Fleetwood Town vs Arsenal?
The EFL have confirmed the match official appointments for the upcoming round of League Cup fixtures, including Arsenal’s trip away to Fleetwood Town.Photo by George Wood/Getty ImagesThe EFL have co...
Calvert liquor store gets license transfer; other business fined
New management will be taking over a liquor store in Dunkirk sometime in November.
Tickets on sale now for 49 Winchester's Charlottesville show next year
49 Winchester, a homegrown Virginia country rock band, is the first band announced for Ting Pavilion's 2027 lineup. Tickets are on sale now.
Clay Walker Christmas coming to NPAC Nov. 29
GREENEVILLE — Rumor has it … it’s shaping up to be A Clay Walker Family Christmas.
‘Dream big’: The Seattle-area kids and teens launching businesses
Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.
How LaLiga Turned a Global Soccer Brand Into an $87 Million U.S. Business
LaLiga’s successful expansion into North America shows how to turn a global sports brand into a sustainable business.
Tractor-trailer crash closes part of US-70W Business
Two lanes are closed on US-70W Business after a crash involving a tractor-trailer.
Business lessons are coming to liberal arts schools
A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.
AP Business lessons are helping high school students learn how to manage money
A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
Local breakfast chain plans Derby expansion
The Easy Egg, a Wichita-based breakfast and lunch restaurant, recently announced plans to expand into Derby. Reports indicate the local chain will take over the space at 317 N. Rock
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
Trump campaigns in Michigan one day after Obama rallied against him
President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.
Tune In: Orlando Pride vs Gotham FC on CBS Sports Network
The Pride host Gotham for the final home game of 2026
Can GE Vernova's Gas Turbines Make Up for a Collapsing Wind Business?
It's a red flag investors would rather not see waving, but most of them may not have put this shift in its proper perspective.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Trump's midterm swing brings him to Michigan as Republicans aim to undermine El-Sayed in Senate race
President Donald Trump's busy midterm campaign schedule is bringing him to Michigan, where Republicans hope to claim an open Senate seat on Election Day.
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
Business Ins and Outs | Atlanta dessert shop, Provisions, Mexirican and donut shop opening
I Tried TikTok’s Viral Pea Salad to ‘Fibermaxx’ My Lunch—and It Didn’t Quite Go According to Plan
There can be too much of a good thing, as my gut found out firsthand.
Politics chat: The polls show a Democratic sweep in the midterms. Can you trust them?
If you look at the few truly competitive seats, polls show a more complicated picture of momentum toward the Democratic Party in midterm House races. For the Senate, Republicans are on defense.
Arsenal squad & fixtures for the 2026 Messi Cup
The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...
The Leaked Mass Effect 5 Trailer Was Enough To Make Fans Go Feral For One Of Its Sexy, Mysterious Squadmates
We've never had a male Quarian on the team before
Cuts to rural healthcare become key issue for upstate votes in race for NY governor
The fight over a consolidation plan for a hospital in Hudson captures a trend throughout the state.
A simple liquid can stop cavities without drilling, major study confirms
A simple liquid painted onto teeth in seconds can stop cavities without drilling, injections, or anesthesia, according to a major clinical trial involving young children. The inexpensive treatment could spare thousands of children painful dental procedures and surgery while paving the way for broader FDA-approved use.
Scientists overcome a hidden obstacle to more powerful quantum computers
Scientists have discovered a way to operate multiple silicon qubits simultaneously with remarkable accuracy, overcoming a major challenge in scaling up quantum computers. Their new technique maintained accuracy of approximately 99.9% even when all five qubits were running at once, opening the door to larger and more powerful quantum processors.
What a Dietitian Wants You to Know About Your Favorite Halloween Candy | Hartford HealthCare
Learn more about News Detail at hartfordhealthcare.org
Six Xbox Game Pass Titles Are Confirmed For The Final Few Days Of October
Here's what's on the way before the end of the month
Photos: Entertainment | Saints vs. Steelers
Check out the entertainment photos from the New Orleans Saints game against the Pittsburgh Steelers for Week 7 of the 2026 NFL season on Oct. 25, 2026 at the Stade de France featuring Burna Boy.
Scientists reveal the hidden danger of missing blood pressure medication
Missing blood pressure medication could mean losing much of its protection against heart attacks and strokes, according to an analysis of more than 91,000 people. Patients who consistently took their medication experienced an 11% reduction in major cardiovascular events, while those who missed too many doses saw little or no measurable benefit.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
Health Ministry announces national clinical trial of psychedelic substances for treatment of PTSD
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'Multwoh' becomes highest-grossing film of CinePanalo
'Multwoh,' a queer romance-horror film, has become the highest-grossing film to emerge from the Puregold CinePanalo Film Festival, the film’s team said Sunday.
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
'Leaky gut' isn’t a medical diagnosis. Here’s what it really means
Here’s what can happen when your intestinal lining becomes inflamed or injured.
Skeleton Festival returns with ghosts, superheroes and family fun
Downtown Harrisonburg was covered with fantasy creatures like dragons, superheroes and princesses Saturday afternoon during the annual Skeleton Festival.
Review: 'Whalefall' a big fish tale thriller within a fraught father/son relationship
Movie reviewer Joshua Hill says 'Whalefall' combines a fraught father/son relationship with a suspenseful narrative featuring excellent sound design and imagery.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
What Californians should know about Prop. 42
The measure could block the billionaire tax — and more.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
Los Angeles Rams vs. Las Vegas Raiders: How to watch the NFL Week 7 game, channel, streaming info and more
Polish team unearths ancient human remains and mystery giraffe skull in Tanzania
The discoveries could shed new light on how prehistoric communities lived, migrated and treated their dead.
Green Bay Packers vs. Detroit Lions: How to watch the NFL Week 7 game, channel, streaming info and more
Cincinnati Bengals vs. Baltimore Ravens: How to watch today, start time, where to stream and more
AV2 Video Codec Adoption Talked Up, SVT-AV2 Being Developed
Back in May the AV2 v1.0 specification was released for this next-generaton, royalty-free video codec
Antarctica’s “Doomsday Glacier” Could Raise Sea Levels Twice As Much as Scientists Feared
Even without further warming, Thwaites Glacier could contribute twice as much to sea level rise by 2100 as previously estimated, according to a revised ice sheet model. Thwaites Glacier in West Antarctica has been retreating and thinning rapidly, while satellites show substantial acceleration in its ice flow. Traditional ice sheet models have depicted slower movement,
4 Android phone features you should never disable when using Android Auto
Some settings are better left untouched