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How Investors May Respond To Melco Resorts & Entertainment (MLCO) Liquidity Jitters Amid Premium Macau Push
In recent weeks, Melco Resorts & Entertainment reported mixed fourth-quarter 2025 results, while major banks including BofA Securities, UBS, and Morgan Stanley updated their research views on the company amid concerns over liquidity, margins, and Macau market conditions. At the same time, Melco underscored its premium positioning by highlighting eight MICHELIN Stars across five Macau restaurants, reinforcing how high-end non-gaming offerings are becoming a central part of its hospitality and...
What the Muppets can teach us about Maine politics
For dreamers like me, the Rainbow Connection seems distant. Our political climate has abandoned what I consider the Muppet spirit: a celebration of wistfulness, a collective made strong by diversity and humble and transparent leadership. Contemporary politics has been like shadow puppets: projections designed to obscure the causes of our dysfunctional society. The Muppets offer […]
Inside Valley Politics: Texas stops building border walls, a new generation of Lucios runs for office
HARLINGEN, Texas (ValleyCentral) — Texas announced it was getting out of the border wall business. After funding was allocated for more federal border wall construction, the state will no longer bu…
Sheridan College dance explores beauty of the ordinary in upcoming performance
Behind the contemporary show is the importance of finding joy in the mundane — the central message behind the program’s spring semester performance.
Central Oregon’s Mt. Bachelor resort gets into the hotel business
"Right place, right time" led the resort to jump on a long-term lease on the road to its lifts.
Café Piro earns James Beard finalist spot; city opens health clinic in Central
This week: Café Piro reaches James Beard finals as El Paso opens a new health clinic, plus updates on trails, public art and EPCC César Chávez holiday changes.
The newest entertainment facility in central Nebraska is now open in Kearney
Drop Zone features an 18-hole putt-putt course, 32 top tracer bays and four pickleball courts.
Opinion: Science Communication Is Central to the Practice of Science
Explaining and defending knowledge is as essential to the scientific enterprise as publishing research.
BOJ to raise rates with eye on Iran war fallout, central bank official says
The Bank of Japan will continue to raise interest rates while keeping a close eye on how the Middle East conflict affects the economy and underlying inflation, a senior central bank official said on Friday.
UCLA women's basketball players say playing other sports helped them
The UCLA Bruins took the court in Phoenix for Final Four practice, then looked back on the fun of playing other sports before choosing basketball.
Multi-million project improves access to rural health care at Central New York hospital
Community Memorial Hospital in Hamilton has completed a $31.5 million dollar project to renovate its emergency department, add a new radiology suite, and create 10 private patient spaces with ICU d…
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 — Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Health’s global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Registrations open for São Paulo School of Advanced Science on Regulatory Governance
School at the Getulio Vargas Foundation (Brazil) covers emerging regulatory frontiers, including central banks in climate risk regulation and antitrust in digital markets. Apply by April 30.
Central banks' inflation mood puzzle: more judgment than science
The world's central bankers may be attempting the impossible: to get into the psyche of business executives, labour unions and ordinary households in real time to understand how they are navigating their finances through yet another energy shock.
Science Museum of Virginia offers front-row seat to Artemis II mission from the Dome
NASA has sent astronauts back toward the moon for the first time in more than 50 years — and Central Virginians can have a front-row seat at the mission without ever leaving the ground.
High Desert Stampede returns to Redmond with rodeo and entertainment
REDMOND, Ore. (KTVZ) -- One of Central Oregon’s signature events has returned for another action-packed year at the Deschutes County Fair & Expo Center. The High Desert Stampede is gearing up to bring rodeo, live entertainment, and community traditions back to Redmond, drawing world-champion competitors and crowds from across the region. It's known for its
DHS pauses new immigrant warehouse purchases as all Noem-era contracts are reviewed
The new Homeland Security Secretary, Markwayne Mullin, was sworn in last week to lead a department that was steeped in controversy during Kristi Noem's tenure but also central to President Trump's mass deportation agenda.
James Uthmeier: 16 suspected child predators arrested in Central Florida investigation
Another 30 suspected child predators were rounded up in other areas of Florida.
Science communication is central to the practice of science
Explaining and defending knowledge is as essential to the scientific enterprise as publishing research.
Can regional sports networks survive, or even thrive? Depends on who you ask
Charlie Jacobs, the CEO of hockey’s Boston Bruins, is convinced that his three children, all in their twenties, will likely never sign up for a traditional cable package to watch television. But his kids will certainly have WiFi in their homes, and through the internet, the ability to watch sports teams all the same. For years, a central question in sports and media has been whether streaming subscribers, as Jacobs’ children would be, could ever drive enough revenue to fill sports stations’ tills. Now, some regional sports networks such as New England Sports Network, or NESN, are...
High school sports results for Tuesday, March 31, 2026
TUESDAY’S RESULTS Baseball WPIAL CLASS 6A Section 1 Butler 4, North Hills 0 Central Catholic 6, Seneca Valley 0 Section 2 Canon-McMillan 10, Woodland...
LEIFRAS Co., Ltd. Signs Sponsorship Agreement with the Japan Sport Association (JSPO), Contributing to the Future of Sports
LEIFRAS Co., Ltd. (Nasdaq: LFS) (the "Company" or "Leifras"), a sports and social business company dedicated to youth sports and community engagement, today announced that it has signed a partnership agreement (the "Agreement") to participate, from April 2026, as an official partner in the Sports Active Partner Program hosted by the Japan Sport Association ("JSPO"), a public interest incorporated foundation that plays a central role in Japan's sports ecosystem. Through this collaboration, Leifra
‘The Drama’ review: Fine performances can’t save uninteresting story
"The Drama," starring Zendaya and Robert Pattinson, fails to answers its central questions, writes Moira Macdonald.
Swope telescope: five decades of observing and reinvention
Astronomer Nidia Morrell looks back on more than 20 years of observing at the Las Campanas Observatory—an era marked by the transition from manual methods to digital systems—and reflects on the enduring relevance of a telescope that remains central to modern astronomy.
I'm 71 raising my grandson in retirement; financially drained
Martin Odum, 71, and his wife have raised their grandson Noah with spina bifida in central Illinois for five years, which has hurt their finances.
Phoenix Suns 'ready' for Dillon Brooks, Mark Williams to return
Phoenix Suns continue four-game road trip March 31 against the Orlando Magic, with Dillon Brooks and Mark Williams closer to returning from injuries.
Mark your calendars: Weekly sports schedule for March 31-April 4
Take a look through the weekly sports schedule for the Central Coast. Read our coverage online or in print.
Exit Interviews: Local Congressional candidates proud to counter divisive politics
A blaze of St. Patrick’s Day and election night activity has burned out in downtown Wilmette. It’s 10:40 p.m., and on a dim and quiet Central Avenue, parking, for once, is plentiful in front of The Wilmette Theatre. Inside the community venue, Phil Andrew is issuing goodbyes and thank-yous to the remaining guests of the […]
"It's My Book!": Bronx Children Light Up as NYC Health + Hospitals/North Central Bronx Puts Free Books in Their Hands - NYC Health + Hospitals
When a child at NYC Health + Hospitals/North Central Bronx clutches a brand-new book for the first time and exclaims, "It's mine!" — that moment is
Silencer Central acquires vacant Wells Fargo building for future growth
A former Wells Fargo call center is off the market -- bought by its neighboring business for future growth.
Air Force and UCF partner to strengthen nuclear science research
Air Force Technical Applications Center collaborates with University of Central Florida to enhance research and workforce development in nuclear science.
March 30: Science Central opens planetarium
FORT WAYNE — A large crowd of children and adults attended the March 25 unveiling of the long-awaited planetarium at Science Central.
UCLA's first dean for Health AI Strategy and Innovation takes office
“The creation of an associate dean in AI speaks to the fact that AI has become central to research, education and clinical operations in the health care system."
UCLA's first dean for Health AI Strategy and Innovation takes office
“The creation of an associate dean in AI speaks to the fact that AI has become central to research, education and clinical operations in the health care system."
Hot dogs and hot laps: Southcentral Alaska ski hill stewards help preserve access to snow sports
Each winter, a mixture of staff and volunteers at Hilltop, Arctic Valley and Skeetawk ski areas cook, shovel and teach the next generation of skiers.
Science Central unveils new planetarium
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He wants kids to love science and to see people who look like them who love it, too
Maynard Okereke, the “Hip Hop MD,” will be at San Diego’s Central Library on April 2 to share his book, “Zombie Spiders and Asteroid Blasters: 16 Incredible Ways that Scientists are Changing the World”
Four takeaways from The Bee’s investigation into Sutter County GOP’s cash haul
Between 2006 and 2020, the Sutter County Republican Central Committee raised an average of $1,070 per year. In 2025, it raised over $743,000.
A historic Bound Brook plaza just reached full occupancy
A long‑standing Bound Brook shopping plaza is now fully leased, with new food science and fitness businesses moving in.
Small Business Showcase and Entrepreneur Awards Reception planned
FITCHBURG — The North Central Massachusetts Chamber of Commerce and the North Central Massachusetts Development Corp. will host the third annual Small Business Showcase & Entrepreneur Awards Reception on Wednesday, April 1.
Stars visit the Flyers after Bourque's 2-goal performance
Dallas Stars (44-18-11, in the Central Division) vs. Philadelphia Flyers (36-24-12, in the Metropolitan Division) Philadelphia; Sunday, 7 p.m. EDT BETMGM SPORTSBOOK LINE: Stars -154, Flyers +129; over/under is 5.5 BOTTOM LINE: The Dallas Stars visit the Philadelphia Flyers after Mavrik Bourque's two-goal game against the Pittsburgh Penguins in the Stars' 6-3 win. Philadelphia has a 16-12-8 record at home and a 36-24-12 record overall.
Central Texas College students explore the science of Cultivation
KILLEEN, Texas (FOX 44) – Temperatures are on the rise and the first signs of spring are starting to bring new growth and color to the landscape as students at Central Texas College begin lea…
Central Texas College students explore the science of Cultivation
KILLEEN, Texas (FOX 44) – Temperatures are on the rise and the first signs of spring are starting to bring new growth and color to the landscape as students at Central Texas College begin learning fir...
The Politics Behind 'No Kings' Protests
Protests are amping up in Central Florida amid the third 'No Kings' protest. Many say this could be the largest in U.S. history. UCF Associate Professor Larry Walker joined FOX 35's Garrett Wymer live via Zoom to examine the political aspect of the protests, and what demonstrators want to see change.
Game Preview: Dallas Stars @ Pittsburgh Penguins 3/28/2026
Who: Dallas Stars (43-18-11, 97 points, 2nd place Central Division) @ Pittsburgh Penguins (36-20-16, 88 points, 2nd place Metropolitan Division) When: 5:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and Victory+, streaming on ESPN+ Pens’ Path Ahead: The Penguins have a back-to-back coming up that will have a major impact on the Eastern Conference playoff race. […]
Classic clash
Blair County’s Makenna Weimert makes a pass over Central Pa.’s Zayona Thomas during the girls game of the 19th annual Altoona Mirror Basketball Classic. Mirror photo by Patrick Waksmunski
Office of Small Business Affairs hosts statewide business & procurement workshop
More than 200 people gathered in the main conference center at the Macon Mall for a statewide Georgia Procurement Workshop, hosted by Macon-Bibb County’s Office of Small Business Affairs (OSBA) in partnership with Georgias Department of Administrative Services and Central Georgia Coalition of Black Businesses. The event was open to all businesses and suppliers interested […]
Sun, sand and science: kick start your summer at the Royal Society Summer Science Exhibition
The Royal Society Summer Science Exhibition returns for 2026, from 30 June to 5 July, with everything you need for a sensational summer in the heart of central London.
Longtime local business sold. Here's what to know about the sale
When the owners of this central Illinois business decided to sell, they were looking for a company that shared their core values.
Police investigate homicide at business in Central Falls, RI
The death of a woman at Sue’s Salon in Central Falls, Rhode Island, is being investigated as a homicide, police said.
HOMETOWN ENTERTAINMENT: Lots of events across southwest and central Virginia this weekend
Grandin Chillage returns Friday to Roanoke with live music and food, along with the long tradition of the MDA Car Show in Salem
3 shot in Central Business District Thursday afternoon, police say
NEW ORLEANS (WVUE) - Three people were shot in the 1400 block of Tulane Avenue in the Central Business District, and police detained one person on the scene, according to police.
AZ Digest. ASU baseball, softball and swimming take care of business
Here are the news and events happening around Arizona sports.
Vote now for Central Jersey Girls Wrestler of the Year
Who's the best girl wrestler in the area? While that's subjective, fans can vote for their choice among 12 candidates.
Science Communication Is Central to the Practice of Science
Opinion | Explaining and defending knowledge is as essential to the scientific enterprise as publishing research.
Central Ohio coffee business fights to keep brewing after farm issue cuts yield
A coffee business rooted in culture and tradition is facing a critical moment.
Patrons celebrates Science Central’s planetarium grand opening
Science Central celebrated the grand opening of its planetarium on Wednesday: a project years in the making.
Science Central’s planetarium opens Wednesday
Get ready to gaze up at the night sky inside 21Country’s only public planetarium. Science Central opened its highly anticipated project Wednesday.
Africa CDC announces 2026 cohort of Young Digital Health Champions
Addis Ababa, March 23, 2026 — The Youth Digital Health Network (YiDHN), a strategic initiative of Africa CDC’s Youth Division, has announced the 2026 Cohort of Young Digital Health Champions (Y-DHC), recognizing emerging young leaders shaping Africa’s digital health landscape. With over 65% of Africa’s population under the age of 35, investing in youth leadership […]
Trump names Jensen Huang, Mark Zuckerberg to 13-member science and tech council
Trump has made securing U.S. leadership in artificial intelligence a central priority of his second term.
Explore the cosmos with Science Central: Planetarium opens to the the public
The Science Central Planetarium opens Wednesday, March 25.
Spring sports heat up Tuesday night in the Heartland
The Cape Central Girls Soccer team played its home opener against St. Vincent, while the Notre Dame Boys Baseball team hosted Portageville on Tuesday.
Students compete at Central Nebraska science fair in Kearney
Organizers said the regional competition featured 40 projects from schools across central Nebraska.
Kent Alterman & Sarah Babineau’s Good Walk Entertainment Inks First-Look Deal With Sony Pictures Television
EXCLUSIVE: Good Walk Entertainment, the production company founded by former top Comedy Central executives Kent Alterman and Sarah Babineau, has signed a first-look deal with Sony Pictures Television....
Why beloved gas station Buc-ee's got an F from Better Business Bureau
The first-ever Buc-ee's location is opening in Arizona, and the travel center just got an F rating from the Better Business Bureau. Here's why.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
NYC Health + Hospitals/Jacobi | North Central Bronx Brings Novel Minimally Invasive Vascular Surgery Procedures to the Bronx - NYC Health + Hospitals
NYC Health + Hospitals/Jacobi | North Central Bronx today announced it has begun offering two types of minimally invasive surgical procedures that were
Rock and roll icon to perform in central Pa. concert this summer
The tour is in support of his new album, “Automatic,” his first original release in five years.
Pop superstar announces summer concert tour, including stop in central Pa.
"The Freedom Tour" will make a stop in Hershey this August.
Two veteran relievers clinch jobs on Diamondbacks' Opening Day roster
Right-handers Jonathan Loaisiga and Joe Ross have made the Diamondbacks' roster for Opening Day. Both will pitch in relief.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
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