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Elections won’t fix America’s political divisions
If you think politics in America could not be more acrimonious than it is right now, don’t bet on it. It’s about to get much worse, unless we, the American people, do something about it.
Canada's trade arsenal packs US political punch
To combat tariffs imposed by his country's hulking southern neighbor, Prime Minister Mark Carney is using asymmetric warfare. Retaliatory 15% to 50% duties hit only $20 bln of goods. Tight US elections in border states, however, turn the sums into a powerful super PAC of sorts.
Many viral DIY home science experiments don't work, but tjos Alka Seltzer lava lamp does
Crimson Crank: Nitpicking Indiana football’s win over North Texas
Picking something to be mad about after Indiana’s comfortable week one win over North Texas
Walton: Mental health resources are economic infrastructure
Melissa Walton of the Oklahoma County Criminal Justice Advisory Council examines how behavioral health investments can support Oklahoma County's growth and workforce.
Yourgene Health Releases IVDR-Certified DPYD Assay for Chemotherapy Toxicity Detection
Yourgene Health launches IVDR-certified DPYD assay in Europe to detect 19 variants linked to fluoropyrimidine chemotherapy toxicity.
Herbert Simon Family Foundation to present experimental creative showcase with ‘Risky Business’
A new “experimental creative showcase” is coming to the Contemporary Art Museum of Indianapolis (CAMi) this fall thanks to the Herbert Simon Family Foundation.
Best TV shows of fall 2026: ‘Slow Horses,’ ‘Monster,’ ‘VisionQuest,’ more
A reimagining of a Stephen King classic. A trio of best friends trying to save the world. A return of a critically acclaimed crime drama. A bevy of new seasons
Police launch criminal investigation into Reform UK donations
The investigation, which follows a broadcast by Channel 4 News, is being folded into the inquiry that has been underway into other donations.
Ben Roethlisberger raises concern over Steelers thin running back room
Former Steelers QB Ben Roethlisberger questioned team's roster construction, warning that depth behind the primary running backs is dangerously thin.
The Elder Scrolls V: Skyrim Official IKEA Mod Features Matt Berry as a Kallax Storage Companion
What We Do in the Shadows' Matt Berry voices an IKEA Kallax bookcase in a free official Creation for The Elder Scrolls V: Skyrim.
Prime Video introduces new lip-sync technology on ‘Maxton Hall’
Visual dubbing using AI and VFX technologies enhances the viewing experience for global customers.
BBH Launches a New Technology Business, Braid, Solving for Intelligent Data Transformation
BOSTON, September 09, 2026--Brown Brothers Harriman (BBH) today announced the launch of a new technology affiliate, Braid LLC, focused on solving enterprise data transformation for financial services. Braid offers an AI-native data transformation platform that gives firms a scale solution to transform, connect, and manage their data with confidence.
Andy Burnham: National security can't come at expense of social security
The prime minister says he will fund defence and get the welfare bill down in "the Labour way".
Sununu to face Pappas in New Hampshire Senate race
Also, Stefany Shaheen won a close primary and will face Republican Anthony DiLorenzo in the race to fill Pappas' open congressional seat
Iowa Football: Numbers To Know Ahead Of Iowa State Game
Saturday's primetime game will be just the 28th night game in Kinnick Stadium history.
Scientists find a bone-building switch that could fight osteoporosis
An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.
Singapore PM salary set to rise to $2.85M under political pay overhaul
Singapore updated its executive compensation benchmarks, setting its prime minister pay target at $2.85 million while capping initial actual raises at 9%.
France to reduce corporate tax surcharge and ease employee buyouts in 2027 budget, PM says
France plans to reduce, but not abolish, the exceptional corporate tax surcharge imposed on very large companies in its 2027 budget, Prime Minister Sebastien Lecornu said in a letter to executives on Wednesday, pledging tax stability to support growth.
Montreal-Based Proteus Labs Partners with Avantis Education to Bring Immersive Virtual Science Labs to Classrooms Worldwide
Proteus Labs, a Montreal-based developer of immersive mixed reality science lab applications for K–12 education, today announced that its unique mixed reality science lab application has been selected to be part of Avantis Education's ClassVR Xcelerate headset and new EduverseSTEM platform, extending hands-on virtual science experiments to schools in 90 countries.
D4 Supervisor Alan Wong seems victory bound
Third party spending evaporates after a costly primary.
Singapore’s Prime Minister Gets a Big Raise
Singapore’s prime minister, Lawrence Wong, got the bump as part of a longstanding policy to pay high salaries to public servants in order to attract top talent and prevent corruption.
Serbia to hold October snap election
The ruling SNS party named President Aleksandar Vučić as its candidate for prime minister
The Establishment Pulls Through: Five Takeaways from the New Hampshire Primaries
The U.S. Senate race will feature familiar faces: former Senator John E. Sununu and Chris Pappas, a four-term congressman. Stefany Shaheen, a senator’s daughter, eked out a win in a House primary.
Rhode Island's governor faces formidable primary opponent and more to watch today
Report that Netanyahu was warned before October 7 triggers political earthquake in Israel
An investigation published by 'Haaretz' claims the Israeli prime minister was informed by UAE President Mohamed bin Zayed, 10 days before the attack, that Hamas was planning a major operation against Israel.
A rare thing in American politics may happen in Rhode Island on Wednesday
Gov. Dan McKee barely beat Helena Foulkes in 2022. For Wednesday’s rematch, the former CVS executive has outraised him and appears well positioned to win.
The world’s best-paid politician is getting a $1 million pay rise
Singapore’s ministers are already among the world’s highest-paid politicians, with Prime Minister Lawrence Wong earning more than four times US President Donald Trump’s annual government salary.
Legislators receive science education center proposal
Legislators on the Interim Joint Committee on Education recently expressed interest about boosting Kentucky’s science education while hearing a proposal for the creation of the Kentucky Center for Science Education.
'Our year': Kane and Bayern primed for Champions League tilt
Bayern Munich have made it clear their main goal this season is to win the Champions League after recent near-misses, with Harry Kane saying "it has to be our year".Bayern have twice made the Champions League semi-finals in Kane's three years at the club, but no further.
August 2026 Michigan legislative roundup: Money out of politics, prison safety and primary care
Each month, The Michigan Daily publishes a compilation of some of the most relevant bills in the Michigan Legislature for students.
Dan Lanning's Ducks still not ready for college football's primetime
Oregon struggled to find consistency against Boise State to open the season.
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | WWJ Newsradio 950
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | K-DAWN
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a four-term Democratic congressman, will face off against Republican and former U.S. Senator John E. Sununu.
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a moderate Democrat and current Congressman in the 1st Congressional District, will face off against Republican and former U.S. Senator John E. Sununu.
Trump-Backed Auto Executive Wins House Primary in New Hampshire
Anthony DiLorenzo, an automotive executive who ran with the president’s endorsement, will be the Republican nominee in the First Congressional District.
Bernalillo County DA highlights need for accountability and reform in juvenile crime and behavioral health
Bernalillo County District Attorney Sam Bregman addressed crime, juvenile reform and behavioral health during a speech in Albuquerque, emphasizing the importance of accountability and treatment working together.
John E. Sununu Wins Republican Senate Primary in New Hampshire
The general election race to replace Jeanne Shaheen, a Democrat, could help determine control of the U.S. Senate.
Chris Pappas Defeats Progressive Challenger in New Hampshire Senate Primary
Mr. Pappas, a moderate Democrat who has served four terms in the House, will face former Senator John E. Sununu, the Republican nominee, in November.
Logan Health primary care providers sign no-confidence vote
Logan Health primary care providers are raising concerns about leadership, signing a vote of no confidence.The vote comes after months of bargaining between Log
Canada hits US imports with tariffs, intensifying trade war
Canada imposed tariffs of 15% to 50% on hundreds of products from the U.S. on Tuesday, as Prime Minister Mark Carney bets that standing up to President Donald Trump will
Incumbent GOP governor rolls to primary victory after keeping Trump at a distance
Kelly Ayotte cruised past Republican primary challengers, setting up a high-stakes New Hampshire governor's race against Democrat Cinde Warmington.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Supreme Court rejects Missouri's push to use new Republican-drawn U.S. House map in November
Missouri's new districts were used in the August primaries, but the Missouri Supreme Court ruled in September that the state must revert to districts adopted after the last census.
Glendale Actress Finds Love of Science
A few years ago, Marilyn Heidecker was more likely to portray a criminalist on TV, film, or stage rather than work as an actual scientist who analyzes physical evidence in
Live results: Delaware primary election
See Delaware election results and maps for the 2026 primaries.
Live results: Rhode Island primary election
See Rhode Island election results and maps for the 2026 primaries.
Live results: New Hampshire primary election
See New Hampshire election results and maps for the 2026 primaries.
Democratic socialist candidates stirred the primary election pot. But can they win in November?
An MSU Denver political expert discusses what’s behind their emergence, what they stand for and whether they can achieve lasting impact.
Joint Observations with Swift removed from IXPE GO Cycle 4
The IXPE Guest Observer (GO) Program solicits proposals for investigations in any area of astrophysics (not constrained to IXPE’s prime science areas).
Independent Kansas health systems launch shared services organization
Five Kansas health systems have launched a regional collaboration, called Astra Health, to pool resources and coordinate services while retaining their independence. | Astra Health's five founding members, who serve more than half a million patients annually, hope to improve quality and trim costs at scale while maintaining their independence.
US House bill requires criminal background checks on Hollywood sets
A House bill would require criminal background checks for Hollywood set workers who supervise or regularly interact with minors.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Beacon Behavioral Health Partners Acquires 2 Texas Providers
Beacon Behavioral Health Partners is continuing its acquisition efforts with the purchase of Dallas-Fort Worth (DFW) providers Prime Psychiatry and
Beacon Behavioral Health Partners Acquires 2 Texas Providers
Beacon Behavioral Health Partners is continuing its acquisition efforts with the purchase of Dallas-Fort Worth (DFW) providers Prime Psychiatry and
‘Furious’ creator breaks down season 1 finale and teases what’s next for Alice
‘Furious’ creator Liz Meriwether breaks down the shocking finale and what’s next for the crime drama: ‘I’m definitely not using the show as a platform to advocate murdering people.’
Trinity Health in Livonia to lay off 557 employees starting in October, primarily in IT support
Trinity Health’s Livonia location will permanently lay off 557 employees, largely in its technology and information services division, the Michigan Department of Labor and Economic Opportunity announced recently. Layoffs are scheduled to begin Oct. 25 and continue through Nov. 29, according to a notice published by the department. The layoffs come months after Trinity Health […]
Trade war shock: Tariffs push Canadian small businesses to the brink
The economic pain that Canadian Prime Minister Mark Carney warned would come from a trade war is now a harsh reality for some small businesses that export to the US.
15 best TV shows to watch this fall
From a reimagining of a Stephen King classic to the return of a critically acclaimed crime drama, here are 16 shows to be excited about this fall.
Best TV shows of fall 2026: ‘Slow Horses,’ ‘Monster,’ ‘VisionQuest,’ more
From a reimagining of a Stephen King classic to the return of a critically acclaimed crime drama, here are 16 shows to be excited about this fall.
Canada hits US imports with tariffs, intensifying trade war
Canada imposed tariffs of 15% to 50% on hundreds of products from the U.S. on Tuesday, as Prime Minister Mark Carney bets that standing up to President Donald Trump will
In 2018, scientists seeded clouds over China's Muz Taw Glacier to make snow; the brighter surface was followed by 14% to 17% less ice loss in a preliminary experiment
Researchers in China have tried to make artificial snow over China’s Muz Taw Glacier to slow its melting. The experiment conducted in 2018 involved seeding clouds with silver iodide, which helped trigger snowfall over the glacier.
AI Factories Turn Infrastructure Into a Business Advantage
AI factories are an industry must as enterprises move from experimentation to scaled agentic workloads, says Penguin Solutions’ Aaron Johnson.
How to watch the 2026 Emmys: Start time, where to stream, full nominee list and more
Are you ready for the 78th Primetime Emmy Awards?
Deluzio Says He 'Might' Challenge Fetterman For Senate Seat
According to Merriam-Webster, the word "Might" functions primarily as a modal verb indicating possibility or uncertainty. In politics, it provides an open door to speculation for any and all political pundits. Rep. Chris Deluzio (D-17) propped that door ajar on Sunday when he indicated he 'might' mount a primary challenge…
How UC Davis Strengthens the Forensic Science Workforce
Meet UC Davis students and alumni using a forensic science degree to build careers analyzing DNA evidence and chemicals in crime labs.
Sony is reportedly preparing a big update for the PS5 and PS5 Pro with improvements to PSSR 2.0 upscaling
Sony is reportedly getting ready to release a major new system update for the PS5, with firmware version 14.0 currently is beta.
Former MSU Interim AD Jon Palumbo Heading to Kentucky
The Spartans’ leadership exodus continues as another top executive reunites with J Batt in Lexington, leaving East Lansing to navigate a shifting front office after months of transition.
Live Results: Rhode Island midterm primaries
Rhode Island Gov. Dan McKee faces a tough Democratic primary challenge Wednesday in his bid for a second full term.
Live Results: New Hampshire midterm primaries
The race to replace retiring three-term Democratic Sen. Jeanne Shaheen is one of a handful across the country that could determine control of the U.S. Senate for the second half of President Donald Trump’s final term.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Ollie Watkins' departure to Al-Hilal - which lurched between acrimonious and emotional - has left Aston Villa without their best attacking outlet. Despite just one goal in his first 13 top-flight games last season, he ended up netting 16, leaving him on 91 Premier League goals - a club record. Nicolas Jackson was brought in as Watkins' direct replacement and was a priority signing for Unai Emery, having worked together at Villarreal.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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