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Truckloads of food are being wasted because computers won’t approve them
Modern food systems may look stable on the surface, but they are increasingly dependent on digital systems that can quietly become a major point of failure. Today, food must be “recognized” by databases and automated platforms to be transported, sold, or even released, meaning that if systems go down, food can effectively become unusable—even when it’s physically available.
Scientists built a quantum battery that breaks the rules of charging
Scientists have taken a major step toward futuristic energy tech by building a working prototype of a quantum battery—one that can charge, store, and release energy using the strange rules of quantum physics instead of chemistry. This tiny, laser-powered device hints at a future where energy storage is not only faster but actually improves as systems get larger, flipping the rules of conventional batteries.
For Many Patients Leaving the I.C.U., the Struggle Has Only Just Begun
A long stay in intensive care can bring physical, cognitive and mental health challenges that can take months or longer to resolve.
DI Sports picks | No. 3 Illinois’ Final Four matchup with No. 2 UConn
The waiting game is coming to an end for No. 3 Illinois as it prepares for its first Final Four appearance in 21 years on Saturday in a revenge game against No. 2 UConn. After two physical, hard-fought wins last week over the No. 2 Houston Cougars and the No. 9 Iowa Hawkeyes, the expectations...
Trooper Steve on Patrol: Inside the ‘toughest 2 minutes in sports’
Trooper Steve on Patrol got a firsthand look at one of the most physically demanding competitions in public safety during a preview of the inaugural All American Challenge & Training Camp.
Biophysicist Joins Ranks of Elite Scientists as AAAS Fellow
Dr. G. Andrés Cisneros has been recognized by the American Association for the Advancement of Science for his contributions to biophysics, computational enzymology and computational chemistry. Dr. G. Andrés Cisneros, professor and department head of physics at The University of Texas at Dallas, has been elected to the 2025 class of American Association for the […]
Physicists Found Something That Can Move Faster Than Light: The Darkness Inside It
This is fine.
Pepperdine Graziadio Business School Announces Physician and Innovator Martha Molina Bernadett (MBA '01, PKE 105) as Distinguished Alumnus Award Recipient
Recognized for her outstanding personal and professional achievements as a healthcare professional, Bernadett currently serves as a University Board member and has been previously recognized with the Waves of Service George Award and as an Outstanding Alumni in Healthcare.
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 — Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Health’s global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Rostrum Pacific’s FatBeats acquires physical distro company Traffic Entertainment, plus D2C store and label
The deal brings together three companies with a combined 50 years of experience in vinyl distribution, physical distribution, and premium catalog re-issues.
Meet the new directors of GLAM, PULSE, and the Ginzton Lab
Three interdisciplinary research labs anchored in the physical sciences have new faculty directors – each a longtime member of the community they’ll now lead.
UNM to host national leader in sports medicine for community lecture on concussions
The University of New Mexico Department of Neurology will host a community lecture featuring Dr. Brian Hainline on Tuesday, April 15 from 6 to 8 p.m., at the Physics and Astronomy Interdisciplinary Science (PAIS) Auditorium on the Albuquerque...
Sports medicine doctor: How to select your best running shoes
This sports medicine physician, who runs regularly, said finding the right running shoe and not overusing it can help prevent injuries.
Sports medicine doctor: How to select your best running shoes
This sports medicine physician, who runs regularly, said finding the right running shoe and not overusing it can help prevent injuries.
Sports medicine doctor: How to select your best running shoes
This sports medicine physician, who runs regularly, said finding the right running shoe and not overusing it can help prevent injuries.
Marshmallow Peeps rule in quest for physics, chemistry
This week in Woo! Science, the approach of Easter means marshmallow Peeps. So, why not take them to the physics lab? And to the chemistry lab?
Recent billing code changes wreaking havoc for radiation oncologists, new survey finds
“This is a financial emergency for our practice,” one physician says, according to a new survey from the American Society for Radiation Oncology.
Physicists just solved a strange fusion mystery that stumped experts
Fusion scientists have solved a long-standing mystery inside tokamaks, the donut-shaped machines designed to harness fusion energy. For years, experiments showed that escaping plasma particles hit one side of the exhaust system far more than the other, but simulations couldn’t explain why. Now, researchers have discovered that the rotation of the plasma itself plays a crucial role—working together with sideways particle drift to create the imbalance.
Hennepin Healthcare workers push lawmakers to shore up support for hospital at risk of closure
Nurses and physicians at Hennepin Healthcare in downtown Minneapolis, home to the first level-one and busiest trauma center in Minnesota, on Wednesday urged the state Legislature to throw the hospital a lifeline — and fast.
Houston doctor shares infertility journey, urges women to ‘own your health’ at Rebuilding HER conference
Dr. Chi Johnson, a Houston family medicine physician, shared her personal and professional experiences with infertility at the Rebuilding HER conference, highlighting the challenges Black women face in being heard by healthcare providers.
Research roundup: 7 cool science stories we almost missed
Sperm gets lost in space; raccoons solve puzzles; the physics of folding a crepe; and more.
If you have Blue Cross Blue Shield health insurance, you'll want to know about this big change
Beginning April 1, Memorial Hermann Health System facilities and physicians are out of network for some BCBSTX plans.
Behind the scenes at the Department of Public Health: How a Harvard physician is supporting child well-being
When Harvard Medical School and Mass General Hospital’s Ingrid Bassett, M.D. ’00, M.P.H. ’07, began her public service leave at the Massachusetts Department of Public Health (DPH), she set out…
A slowdown in US visa processing is wreaking havoc on foreign doctors’ lives
Physicians from countries Trump deemed national security threats are reaching the end of their visas without responses to their renewal applications.
Mental health education for coaches can help young athletes on and off the field
By Erin Harrop Youth athletics have become significantly more intense and competitive. The physical effects of training or injury can be grueling — but so are the mental health effects, particularly as performance pressure increases. As leaders and mentors, coaches play a vital role in building kids’ and teens’ confidence and shaping how athletes value […]
Hundreds of Times Colder Than Outer Space: Scientists Reach Near-Absolute Zero in Dark Matter Hunt
Deep beneath the Earth’s surface, a major physics experiment has reached a critical milestone, enabling detectors to operate at temperatures near absolute zero.
Walkable Neighborhoods Can Boost Physical Activity, Population Health
New research from Washington State University shows that small increases in neighborhood walkability could lead to substantial gains for a sedentary population, boosting individuals’ physical activity and ultimately improving their health.
Two physicists and a curious host walk into a studio…
On GBH’s new show The Curiosity Desk, MIT LIGO researchers revel in the beauties of fundamental discovery science and MIT astronomers talk planetary defense.
Price Hike or Discount? Nintendo's Changes to Physical and Digital Game Pricing Have Analysts Split, Too
Nintendo games are about to get more expensive. Or less. Depending on whether or not you want a physical copy, and how you read its recent decision to charge different prices for physical and digital games in the U.S. What's really going on? As usual, I have turned to a panel of industry experts to explain.
'Only limited by the physics': inside Apple’s AirPods Max 2 and the H2 chip upgrade
We spoke with Apple to unpack what's new with AirPods Max 2
Two's company: ISTA scientists identify new class of star remnants
In the vastness of the Universe, any new object with interesting properties can spur the search for similar objects, potentially establishing a new class of stars. In a paper published in Astronomy & Astrophysics and an arXiv preprint, researchers from the Institute of Science and Technology Austria (ISTA) describe two stellar remnants that share five properties, including X-ray emission, despite being isolated objects. According to the team, these two remnants are sufficient to define a new class of stars.
In MA, Doctors’ Day becomes rallying point for health care reform
Facing federal funding cuts and growing primary care shortages, Massachusetts physicians met with legislators on March 25 at the State House.
This new “phonon laser” could measure gravity more precisely than ever before
Scientists have taken lasers beyond light and into the realm of sound, creating a breakthrough “phonon laser” that manipulates tiny vibrations at the quantum level. By dramatically reducing noise in these systems, researchers can now measure motion and forces with unprecedented precision. This advance could unlock new ways to study gravity, probe quantum physics, and even revolutionize navigation with ultra-accurate, satellite-free systems.
January 6 protesters seek millions in court for ‘physical and emotional injuries’
Several people who were at the US Capitol during the January 6, 2021, insurrection are suing the police agencies that worked to defend the building that day, asking a federal court to award them millions of dollars in damages for the “physical and emotional injuries” they say were inflicted on them by law enforcement.
Columbia University protester says year in ICE custody ‘destroyed’ her physical health
A 33-year-old Palestinian woman said she was “chained” to a hospital bed for three days after suffering from a seizure in ICE custody.
Leadership Training Academy 2026 Recap
PRH’s 2026 Leadership Training Academy brought together physician advocates to advance reproductive justice through policy, care, and community.
Scientists Found a Second Critical Point Explaining Why Water Seems to Break All The Rules
Water is abundant but far from simple. A new discovery brings us closer to understanding its complex physics.
Sports uniform proposal could boost students' physical activity
New research suggests most Australians support a simple change that could significantly boost children's physical activity levels: letting students wear sports uniforms every day. The majority of young ...
Revitalize Your Health This Spring
Key takeaways:Some people put off health screenings and appointments in the winter. Spring is the perfect time to do a reset and see what you need.Everyone should get a yearly physical. Talk to your primary care provider about what other screenings and vaccines you need.Spring can also be a time to recommit to health habits at home, like diet, e...
Quantum physics can confirm where someone is located
The concept of entanglement links far-flung particles. That relationship can prove that someone is in the location they claim to be.
Scientists Just Upended a 300-Year-Old Law of Physics
When load increases steadily, so does friction, but in the realm of magnetization dynamics, things aren’t so simple.
Scientists Just Upended a 300-Year-Old Law of Physics
When load increases steadily, so does friction, but in the realm of magnetization dynamics, things aren’t so simple.
Webb telescope spots mysterious explosion that defies known physics
Astronomers have spotted a bizarre cosmic explosion that refuses to play by the rules—and it’s leaving scientists scrambling for answers. GRB 250702B, detected by NASA’s James Webb Space Telescope and a global network of observatories, lasted an astonishing seven hours—far longer than typical gamma-ray bursts, which usually fade in under a minute.
Why mentorship is vital for the future of physics
Honor Powrie explains why giving back through mentorship is so valuable
‘To do something nobody’s done’: physicist Zhu Zijie leaves Europe for China
Rising star scientist returns to China to undertake cutting-edge research in the field of cold atoms.
Phonons in Focus
Phonon lasers are used to trap and levitate nanoparticles in the laboratory of Nick Vamivakas, the Marie C. Wilson and Joseph C. Wilson Professor of Optical Physics at the University of Rochester. https://www.doi.org/10.1038/s41467-026-70564-3
FIRST ON MS NOW: Pro-Palestinian protester discusses seizure in ICE custody: “my physical health is destroyed”
Leqaa Kordia, a Palestinian woman who was detained by ICE last March after participating in pro-Palestinian protests near Columbia University, was released this month after more than a year in custody. She joins The Weekend: Primetime for her first TV interview since her release to discuss her treatment and conditions inside a Texas ICE detention center.
Scientists Stunned: Colossal Eggs Discovered 3,500 Meters Beneath an Active Volcano
Beneath an active seafloor volcano off Vancouver Island, researchers have documented a congregation of giant eggs at roughly 3,500 meters, a discovery that reframes how life can flourish under extreme conditions. The eggs belong to the Pacific white skate, an elusive deep‑sea species adapted to cold, crushing pressure and perpetual darkness. What seemed an unlikely nursery is actually a geothermally warmed refuge, where subtle heat helps embryos survive a marathon incubation. The finding links volcanic energy to a quiet engine of biodiversity, turning a hostile landscape into an incubator. A living volcano, a hidden nursery The seamount long assumed dormant now exhales mineral‑rich, shimmering plumes, proof of hydrothermal life at depth. Expedition cameras swept across black basalt and pale bacterial mats, revealing vents that pulse with warmth. That warmth, though modest by human standards, alters the physics of development for cold‑adapted embryos. In a realm where metabolism creeps, even a few degrees can mean faster growth and higher survival. The volcano is not only active; it is ecologically formative, drafting a blueprint for a thriving oasis. Giant eggs and a skate built for the abyss The Pacific white skate, Bathyraja spinosissima, is built for the abyss: broad wings, armored spines, and a life history that trades speed for endurance. Females lay outsized, rectangular “mermaid’s purses,” often 46–50 centimeters long, packed with rich yolk to fuel years of growth. In the frigid deep, embryos can require around four years to hatch, a timeline that magnifies every energetic advantage. The scale is striking—large eggs, large adults, and a textbook case of deep‑sea gigantism. The volcano’s gentle heat may literally shave months or years from the wait. Why heat matters at the bottom of the sea Hydrothermal circulation delivers low‑level warmth without the turbulence that would scatter fragile egg‑cases. Slightly elevated temperatures accelerate enzyme kinetics, nudging development along while keeping embryos within a safe range. Mineral‑laden fluids likely shape local microbiomes, which, in turn, can influence biofilms on egg surfaces. The environment acts like a slow, steady incubator, countering the deep sea’s tyrannies of cold and scarcity. For a species with long maturation and few offspring, every incremental boost compounds across generations. An ecosystem sculpted by fire and water Seafloor volcanoes create steep environmental gradients, stitching together hot vents, cool eddies, and mineral gardens into mosaic habitats. Microbes harvest chemical energy, seeding food webs that support crustaceans, fishes, and skates. Cameras documented egg‑cases nestled among rocky ledges, near communities nourished by vent‑driven chemistry. These islands of productivity behave like deep‑sea oases, sustaining life far beyond the vent orifice’s flickering light. The nursery’s success underscores how geological forces engineer biological opportunity. “Finding a cradle of life tucked beneath a breathing volcano reminds us that the planet’s harshest places can be profoundly generous.” What the discovery could change The nursery reframes conservation priorities in regions where volcanism quietly underwrites reproduction. Protecting hydrothermal corridors could safeguard entire lifecycles, not just charismatic adults spotted during occasional surveys. It also sharpens questions about how climate‑driven shifts in ocean circulation might influence vent activity, temperature fields, and embryo survival. With methodical mapping, time‑series cameras, and environmental DNA, scientists can track whether nurseries remain stable or drift with geologic rhythms. Key implications include: Enhanced understanding of deep‑sea reproduction at hydrothermal sites. New conservation targets centered on geothermal nurseries. Comparative studies with other volcanic regions, from the Galápagos to rift zones. Biotechnological insights from organisms adapted to long, cold development. Better models of how seafloor heat shapes regional biodiversity. Methods behind the revelation Remotely operated vehicles threaded through chimney fields, gathering video, temperatures, and mineral signatures. High‑definition imagery captured the distinctive, horned egg cases, their edges dusted with fine volcanic silt. Geochemical profiles mapped how heat and chemicals disperse, outlining the “thermal lanes” where eggs most cluster. Combined, these datasets reveal a nursery organized by geothermal topography, with egg‑cases concentrated in pockets of gentle, sustained warmth. A fragile boon in a changing ocean Deep‑sea environments feel remote, yet they intersect with global pressures: mining proposals, cable routes, and shifting oxygen levels. The nursery’s resilience hinges on stable heat flow, intact substrates, and minimal disturbance from noise or sediment. Safeguarding such places is not just about protecting novelty; it preserves a slow, ancient strategy that lets large, long‑lived animals endure in the coldest reaches of the Pacific. Where geology and biology meet, the planet’s deep time still writes living stories. This volcano‑warmed nursery adds a vital chapter to that story, revealing how subtle thermal gifts can tip the scales toward life in the abyss. With each dive, researchers trace the contours of an unseen world, where fire feeds water, and water—against all odds—feeds the future.
USC CHIRP Lab program uses barbershops, Fitbits to address health gaps for Black and Latino men
Researchers at the University of South Carolina are testing a new approach to reach Black and Latino men where they already gather, the barbershop, to improve mental health, physical health, and overall well-being.
Apple CEO Says Get Off Your Phone (And Science Agrees With Him)
Smartphone dependence can have significant negative effects on both mental and physical health, which is why it's good to limit screen time to just a few hours.
This quantum computing breakthrough may not be what it seemed
A team of physicists set out to test some of the most exciting claims in quantum computing—and found a very different story. Instead of confirming breakthroughs, their careful replication studies revealed that signals once hailed as major advances could actually be explained in simpler ways. Despite the importance of these findings, their work initially struggled to get published, highlighting a deeper issue in science.
Scientists discover liquids can fracture like solids under extreme stress
Scientists discovered that simple liquids can snap like solids when stretched fast enough, challenging fluid physics fundamentals.
Scientists mimicking the Big Bang accidentally turn lead into gold
The physicists made an unexpected breakthrough
FMOL Health physicians lead collaborative, innovative approaches to care across the Gulf South
While many people associate doctors primarily with exam rooms, procedures or hospital visits, physicians today play a much broader role in modern healthcare. At FMOL Health, doctors are not only
Impossible Science Live! with World Champion of Magic Jason Latimer
Impossible Science Live! with World Champion of Magic Jason Latimer From bending light with physics, to shaping water with chemistry and walking through solid glass with engineering, World Champion of Magic Jason Latimer’s mind-blowing live show delivers an inspiring message of how “The right question changes everything.” Impossible Science LIVE! expands on Jason Latimer’s inspiring TED Talk “ Seeing Beyond the Illusion of Knowledge ” with family-friendly, mind-blowing illusion entertainment. Uniting his favorite illusions from his illustrious career, Latimer reveals the secret to his magic is not special powers but simply a pursuit of challenging the impossible with curiosity. During your museum visit from April 7-11, 2026, drop into the auditorium for one of Latimer’s shows throughout the day. Shows are included with your Spring Break admission and FREE for museum members. Add a membership to your cart for free Spring Break admission! Available showtimes: 10:30 a.m., 11:30 a.m., 1 p.m., 2 p.m. daily, with a 3:30 p.m. show on Saturday, April 11. Open seating; first come, first seated. About Jason Latimer: Jason Latimer has been featured on television around the world as both a scientist and magician. While Latimer is both a curator of the iconic Fleet Museum in San Diego, CA, and a World Champion Magician his network specials, TV series, and appearances span the globe. Jason has been featured as a science host on the Science Channel, Roku, Amazon, and as a magician on the Syfy Channel, History, BBC ONE, and Japan’s NHK. In 2021, SONY partnered with Latimer to bring his unique blend of science and magic to online and to PBS to assist with distance learning. Impossible Science’s growth has been exponential ever since, garnering over a hundred million views and multiple streaming awards as an educational series.
Pokémon GO Datamine Reveals Explorer Gadget, a Virtual Auto-Catching Item
Trainers, a new in-game item that could fundamentally change we Trainers play Pokémon GO has been spotted in the game’s code. According to a recent datamine by the ever-watching PokeMiners, Scopely is working on an item called the Explorer Gadget, which appears to replicate the functionality of physical auto-catching devices like the GO Plus and […]
SETTLEMENT BY GUILLEMOT BROTHERS LIMITED OF PREPAID FUTURES CONTRACTS FOR UBISOFT ENTERTAINMENT SA SHARES
SETTLEMENT BY GUILLEMOT BROTHERS LIMITED OF PREPAID FUTURES CONTRACTS FOR UBISOFT ENTERTAINMENT SA SHARES London, March 27, 2026 – Guillemot Brothers Limited announces having physically settled at maturity, on March 23, 2026: the prepaid future contract for 606,061 Ubisoft Entertainment SA shares, andthe prepaid future contract for 2,424,242 Ubisoft Entertainment SA shares, (together, the “Shares”). both entered into between Crédit Agricole Corporate and Investment Bank (« CACIB ») and Guillemot
Article highlights role of hospitals in advancing women’s health
An article in the current edition of AHA Trustee Insights highlights how health care professionals across America’s hospitals and health systems — physicians, nurses and other caregivers, as well as administrators and trustees — are enhancing the way care is delivered to women, which can lead to a win-win scenario for patients, communities and hospitals.
Houston sports suffers double defeat: Astros fall to Angels, Houston Cougars eliminated from NCAA Tournament
It was a rare "double loss" day for the City of Champions. From a stagnant offense at Daikin Park to a physical exit at the Toyota Center, we recap the two major losses for Houston sports fans.
Boston Children's enhances care with clinical intelligence platform
Two of the hospital's physicians explain how the decision support technology aggregates patient signals to indicate health trajectories – which tells clinicians when to evaluate a patient's evolving state and determine an appropriate response.
Brian Cox says physics faces ‘unquantifiable’ threat under punishing funding cuts
Cuts of nearly 70% may force university departments to close and damage UK’s research progress, senior scientists say
Super Meat Boy 3D physical editions announced for PS5, Switch 2
Meridiem will release physical editions of Headup-published and Sluggerfly- and Team Meat-developed 3D platformer Super Meat Boy 3D for PlayStation 5 and Switch 2, the distributor announced. They w…
The Startup Selling Full-Body Scans as the Future of Health Care
Step into the machine at Neko Health or one of its rivals to check for skin cancer, diabetes or stroke risk. Is this the next frontier in preventative health care, or something your primary care physician would rather you avoid?
Future physicians need more nutrition education — but not of the MAHA variety
Credible nutrition educators and scientists need to be closely involved as medical schools add more instruction on nutrition.
Breaking down barriers to mental health support
By removing stigmatizing credentialing questions and creating a peer support network, Bayhealth is aiming to help physicians feel comfortable seeking the behavioral health care they need.
PSA: Sonic Racing: CrossWorlds Is Now Available Physically On Switch 2
And it's not a Game-Key Card
Dogs can help boost mental and physical health, but it's important to understand their feelings, too
These tips for interpreting a dog's behavior can strengthen our bonds with our pets.
Oscars to leave Hollywood's Dolby Theatre in 2029
In addition to the physical relocation, the Oscars will shift to YouTube, a major reset as the show looks to expand its reach after years of declining TV audiences.
Two Argonne scientists elected Fellows of the American Association for the Advancement of Science
Argonne National Laboratory scientists Brian Toby and Carlos Wagner have been elected AAAS Fellows for advances in crystallography and particle physics, recognizing their influential research, software and instrumentation development, and mentorship.
Nintendo Switch 2 digital games to cost less than physical versions in US
Platform holder says change "simply reflects the different costs associated with producing and distributing each format"
‘Beyond the Gates’: Tamara Tunie on Anita’s Devastating Cancer Low Point
Tunie opens up about the emotional and physical toll of the 'powerful' storyline, as well as how viewers have responded to Anita's cancer experience.
The Most Overlooked Sign of Chronic Inflammation, Per a Holistic Health Doctor
Dr. Taz Bhatia reveals the physical changes you don't want to ignore and how to treat them.
Nintendo will start charging more for physical Switch 2 games than digital copies
The first physical game affected will cost $10 more than a digital copy.
Nintendo to start charging different prices for first-party digital and physical games
Nintendo just announced it will begin charging different prices for first-party Switch 2 games based on digital or physical purchases. The new Yoshi game will cost $60 digitally, but $70 for a physical copy.
Greenville women’s health clinic closing after nearly 40 years
Physicians East announced that Greenville Women’s Care, located on Stantonsburg Road, will close on June 1, 2026.
Nintendo To Change Pricing For Digital & Physical Switch 2 Exclusives, Starting With Yoshi
Digital to be cheaper than physical going forward
Amendment 50: Physical Sciences: Research Studies Not Solicited in ROSES-25
The NASA Physical Sciences (PS) program is part of the Biological and Physical Sciences Division. This program element will investigate physical phenomena in
NASA ROSES-25 Amendment 50: Physical Sciences: Research Studies Not Solicited in ROSES-25
The NASA Physical Sciences (PS) program is part of the Biological and Physical Sciences Division
Baptist Health-Fort Smith may cease full hospital operations - Talk Business & Politics
Little Rock-based Baptist Health is planning to end hospital operations at Baptist Health-Fort Smith with the campus providing emergency room and possibly limited surgery services. Existing physician agreements are set...
NASA Awards Astrophysics Postdoctoral Fellowships for 2026
The highly competitive NASA Hubble Fellowship Program (NHFP) recently named 24 new fellows to its 2026 class.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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