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Non-Las Vegas Raiders quarterbacks who have the most pressure on them heading into the 2026 season

The Las Vegas Raiders are heading into a very, very crucial season where they have to get it right, and a lot of players are under pressure.

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Jul 6 • 1:26 AM EDT • Sports • sports.yahoo.com
‘Game of the Tournament’ — Shannon Sharpe, Sports World React to England’s Stunning World Cup Win vs. Mexico

On paper, there should have been no contest. England has a star-studded team, and while Mexico were playing at the legendary Estadio Azteca in front of about 80,000 fans, the odds were stacked against them.

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Jul 6 • 1:08 AM EDT • Sports • sports.yahoo.com
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World Cup 2026: Mexico 2-3 England - Three Lions into quarter-finals after knocking out co-hosts in epic five-goal thriller

Match report as England beat Mexico in five-goal thriller; kick-off delayed by an hour; Jude Bellingham scores twice in 98 seconds before Julian Quinones pulls one back; Jarell Quansah sent off but Harry Kane nets penalty; England face Norway on Saturday in quarter-finals

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Jul 5 • 11:00 PM EDT • Sports • skysports.com
Vandalia Health promotes AJ Hammond to vice president of external affairs and government relations

Vandalia Health promoted Albert “AJ” Hammond to vice president of external affairs and government relations, where he will lead legislative, public policy and government affairs strategy statewide.

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Jul 5 • 8:22 PM EDT • Health • mybuckhannon.com
How Splash helps Sacramento-area students explore science, nature beyond class

Splash, a nonprofit organization founded in 1999, works with capital region schools to teach kids about science in a hands-on way.

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Jul 5 • 2:38 PM EDT • Science • sacbee.com
NCAA president Charlie Baker floats regional approach to non-football sports

Conference realignment has turned college athletics into a much more national endeavor than it ever was previously. The Big Ten stretches from Southern California to New Jersey. The ACC includes a pair of teams on the Pacific coast. And the Big 12 has members located in both the deserts of the Southwest and the mountains…

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Jul 5 • 2:30 PM EDT • Sports • sports.yahoo.com
Fossil teeth smaller than a nail may rewrite human origin stories - Futura-Sciences

A shrew sized primate ancestor Purgatorius first appears in the fossil record around 65.9 million years ago. This timeline places the animal just after the Cretaceous-Paleogene asteroid impact that eliminated non-avian dinosaurs. The creature was a small, tree-dwelling mammal about the size of a modern shrew. Scientists classify it as...

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Jul 5 • 8:30 AM EDT • Science • futura-sciences.com
Grassroot Institute Aims To Keep Growing Its Political Influence

Now in its 25th year, the nonprofit policy research organization wants to play a larger role in influencing state and county governance.

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Jul 5 • 6:01 AM EDT • Politics • civilbeat.org
Arts nonprofit hires marketer from restaurant group; new leaders at university foundations

Take a look at some of the recent promotions and new hires announced at south Louisiana businesses.

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Jul 5 • 5:00 AM EDT • Business • nola.com
Letter: Oklahoma must face its maternal health crisis

Oklahoma generally scores below the majority of states in terms of maternal health metrics, highlighting gaps in access to care and resources.

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Jul 5 • 1:01 AM EDT • Health • nondoc.com
Caitlin Clark Targeted In WNBA, Sophie Cunningham Says

Cunningham calls out the WNBA and refs, claiming Clark takes nonstop cheap shots with little protection despite a growing list of flagrant fouls.

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Jul 4 • 2:11 PM EDT • Sports • sports.yahoo.com
Madison Square Garden Entertainment Corp. (MSGE) To Remain Fully Operational Amid New York Penn Station Redevelopment

Madison Square Garden Entertainment Corp. (NYSE:MSGE) is one of the top stocks to buy according to Ariel Investments. On June 9, Madison Square Garden Entertainment Corp. (NYSE:MSGE) entered into a non-binding agreement with Penn Transformation Partners for the development of the New York Penn Station. Under the terms of the agreement, Madison Square Garden will […]

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Jul 4 • 9:35 AM EDT • Entertainment • finance.yahoo.com
China Issues Guide for Registering International Science Groups

China issued guidance for establishing international scientific organizations in the country, setting out registration requirements for nonprofit groups focused on scientific cooperation, exchange and governance.

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Jul 4 • 6:58 AM EDT • Science • bloomberg.com
NBA Fans Bracing For Blockbuster Anthony Davis, Cavaliers Trade

Anthony Davis isn't a free agent but he's still commanding a ton of attention this NBA offseason. The Washington Wizards have already said they have no interest in trading Davis, especially since he's eligible for a contract extension. Nonetheless, trade rumors involving the All-Star forward just ...

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Jul 3 • 5:01 PM EDT • Sports • sports.yahoo.com
Naks Pan is a new salt bread business on Oʻahu

The home bakery specializes in shio pan, or salt bread, and cream pan. The Japanese bread rolls are available in a variety of flavors, while the cream pan…

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Jul 3 • 5:00 PM EDT • Business • alohastatedaily.com
Long Reads for the Long Weekend

(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards

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Jul 3 • 2:38 PM EDT • Entertainment • entertainment.substack.com
Cruz pushes bill to hold tax-exempt sponsors accountable as DOJ probes Singham network

Ted Cruz pushes the SPONSOR Act to strip tax-exempt status from nonprofits funding political violence as the DOJ launches a grand jury probe.

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Jul 3 • 9:49 AM EDT • Politics • foxnews.com
Chicago mental health response teams see 911 calls plummet

A sharp decline in dispatches, staffing shortages and the loss of police dispatch technology have hampered Chicago's non-police mental health crisis response program

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Jul 3 • 8:00 AM EDT • Health • ems1.com
Comparative Analysis of every Water Starter in Pokémon GO

With Sobble Community Day, Pokémon GO trainers will have every single available -type starter in the franchise with their exclusive Community Day moves, obviously until Pokémon Winds and Waves debuts the undeniably cool Gecqua. Sporting the powerful Hydro Cannon, these Pokémon are known for creating waves in the meta, quite literally! But with types being […]

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Jul 3 • 4:33 AM EDT • Technology • pokemongohub.net
This satellite constellation transformed earth science by creatively tuning in to GPS signals

When NASA's Cyclone Global Navigation Satellite System, or CYGNSS, launched into orbit in 2016, none of the University of Michigan Engineering researchers who developed the system expected it to transform ...

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Jul 2 • 7:40 PM EDT • Science • phys.org
‘Check Your Political Identities at the Door’: Lawmakers Come to UVA Darden to Practice Leadership

A select group of state legislators will gather at UVA Darden for a nonpartisan leadership program focused on productive disagreement, values-based decision-making and leading across political differences.

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Jul 2 • 7:34 PM EDT • Politics • news.darden.virginia.edu
Providing Outdoor Science Education

Science Kids was one of 15 nonprofits that received funding from the Sheridan-Johnson Counties Local Board of the Wyoming Community Foundation as part of their spring competitive grant cycle. Sheridan Media’s Ron Richter has more. Science Kids in Sheridan started in 2009. The nonprofit provides outdoor, hands-on science education and summertime classes for youth ages […]

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Jul 2 • 7:25 PM EDT • Science • sheridanmedia.com
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On the Partnership Between the U.S. Government and Science in Figuring Out the Nature of UAP

Below is the transcript of an interview that I just had with Shannon Cake on Newsmax (which is accessible in video format here). Shannon’s…

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Jul 2 • 6:40 PM EDT • Science • avi-loeb.medium.com
VivoPower Reinforces Focus on AI Data Center Business and Provides Update on Non-Core Businesses

LONDON, UNITED KINGDOM, July 02, 2026 (GLOBE NEWSWIRE) -- VivoPower PLC (NASDAQ: VIVO) (“VivoPower” or the “Company”), a B Corp-certified global developer and owner of powered land and data center infrastructure for AI compute applications, today provides the following update in respect of its strategic direction and the previously announced separation initiatives relating to its subsidiaries Tembo e-LV B.V. (“Tembo”) and Caret Digital (“Caret Digital”). Following a strategic review, the Board o

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Jul 2 • 5:25 PM EDT • Business • finance.yahoo.com
HCA Healthcare Foundation awards grants to 89 Middle Tennessee nonprofits, advancing community health

In 2026, the HCA Healthcare Foundation has awarded $2.1 million in grants to 89 nonprofit organizations across Middle Tennessee.

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Jul 2 • 4:23 PM EDT • Health • hcahealthcaretoday.com
Current Political Problems for Science Call for More than a Political Response

“In the end, more than they wanted freedom, they wanted security and they wanted a comfortable life. And they lost it all – security, comfort and freedom. The Athenians finally wanted not to give to…

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Jul 2 • 3:10 PM EDT • Science • headlines.ametsoc.org
Oregon’s top public health official resigns

Oregon’s top public health official is stepping down from her role after two and a half years. Dr. Sejal Hathi, who joined the Oregon Health Authority in January 2024, will leave Aug. 1 to focus on family and personal priorities, the governor’s office announced Thursday. Hathi, who earns $265,488 per year, joined the Oregon Health […]

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Jul 2 • 2:35 PM EDT • Health • oregoncapitalchronicle.com
Opinion | Trump administration move poses an existential threat to science

"The new threat can be found in the 412-page proposed rule from the Office of Management and Budget," two professors emeriti write. "It seeks to put all federal funding decisions, for science and non-science, in the hands of political appointees with no expertise."

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Jul 2 • 2:30 PM EDT • Science • startribune.com
Trump-backed organizer of America’s 250th birthday events may have duped donors, report from House Democrats alleges

Donors who intended to support a bipartisan nonprofit that’s organizing celebrations for America’s 250th anniversary were allegedly redirected – without their knowledge – to a separate nonprofit behind events being promoted by President Donald Trump, according to a report from a group of House Democrats, citing confidential, unnamed sources.

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Jul 2 • 10:17 AM EDT • Politics • cnn.com
CVS Health Foundation Invests $1 Million in Rhode Island Nonprofits Tackling Community Health Needs

Local organizations receive Hometown Fund support to expand access to health care, food, housing and essential services WOONSOCKET, RI / ACCESS Newswire / July 2, 2026 /Originally published on CVS Health Company Newsroom The CVS Health Foundation ...

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Jul 2 • 8:30 AM EDT • Health • finance.yahoo.com
We’re in the game: Bear Bryant Award returns to EA SPORTS College Football 27

HOUSTON, July 2, 2026 – The name of the legendary Paul “Bear” Bryant is synonymous with excellence in the game of college football, and once again, fans playing EA SPORTS College Football 27’s Dynasty Mode will have the chance to win the American Heart...

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Jul 2 • 8:00 AM EDT • Sports • newsroom.heart.org
What are the 'top workplaces' in the New Orleans area? Check out this year's awards.

The annual competition identifies exemplary companies via independent, anonymous surveys of their employees. This year, more than 41,000 workers were surveyed.

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Jul 2 • 8:00 AM EDT • Business • nola.com
'The old politics are gone': Steve Bannon on the democratic socialist wave

Trump's former White House chief strategist argues the U.S. is in a transformational political moment — and leadership in both parties are way behind.

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Jul 2 • 5:55 AM EDT • Politics • politico.com
Elevance pays CMS $342M to assuage concerns of noncompliance and overbilling

The Medicare Advantage insurer said the payout is equal to what a CMS audit stated was the total amount the company was overpaid for patient care services. Despite receiving the cash, the agency has yet to officially withdraw its enforcement action, as the two parties are still negotiating.

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Jul 2 • 4:10 AM EDT • Health • healthexec.com
Sobble Community Day: Your Go-To PvE Guide

Sobble Community Day makes Inteleon a strong Water-type raid attacker with Hydro Cannon and a valuable future pick for Max Battles.

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Jul 2 • 3:54 AM EDT • Technology • pokemongohub.net
Reflecting on a Year as Athlon Sports' Senior Golf Writer: Lessons from Golf's Stories

One year ago today, I officially began my run as Senior Golf Writer for Athlon Sports. By the time this opportunity arrived, I had already spent nearly three decades in golf as a PGA Professional, coach, educator, business owner, nonprofit founder and writer. The biggest lesson from my first year with Athlon Sports was not about deadlines, access or the volume of stories written.

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Jul 1 • 6:20 PM EDT • Sports • sports.yahoo.com
British Business Bank bolsters board with four new directors

The British Business Bank has appointed four new non-executive directors across its boards, effective July 1, as chair Stephen Welton CBE is confirmed for a second three-year term

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Jul 1 • 5:42 PM EDT • Business • marketsgroup.org
Johnny Manziel Unloads On Critics Of His 'Hate' For Cleveland

If you're going to insult Johnny Manziel, do it at your own risk. Back in the September of last year, Manziel ripped the Cleveland Browns while on Shannon Sharpe's “Nightcap” podcast. The former Heisman Trophy winner said he wanted the Browns to go 0-16 during the 2025 season. "I think I will ...

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Jul 1 • 3:12 PM EDT • Sports • sports.yahoo.com
Maine high court considers trans signature debate

The debate Wednesday focused on Bellows’ obligation to balance the U.S. Constitution, the Maine Constitution and a 2022 federal consent order requiring Maine to allow nonresidents to circulate petitions.

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Jul 1 • 1:59 PM EDT • Politics • spectrumlocalnews.com
Gift From Phil Hochberg ’61 Combines His Passion for Newhouse, Sports and DC

A prominent lawyer, Phil Hochberg is also well-known in Washington, D.C., as a former MLB, NFL and college public address announcer.

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Jul 1 • 10:01 AM EDT • Sports • newhouse.syracuse.edu
Sony will cease production of discs for new PlayStation games in 2028

New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?

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Jul 1 • 8:00 AM EDT • Technology • gamefile.news
Opinion: Michigan’s nonprofits are vital infrastructure, not a nice-to-have

Nonprofits work every day standing at the center of some of the hardest realities of our time.

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Jul 1 • 8:00 AM EDT • Business • crainsdetroit.com
NJBIA to Honor Kim Guadagno with Caren Franzini Leadership Award at NJ Women Business Leaders Forum

Kim Guadagno, a trailblazer who served as New Jersey’s first Lieutenant Governor and later continued her public service in nonprofit leadership, will be honored with the Caren Franzini Leadership Award at the 12th Annual Women Business Leaders Forum, powered by Citizens and presented by NJBIA, on Sept. 23 and 24 in Atlantic City. The Women[...]

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Jul 1 • 7:24 AM EDT • Business • insidernj.com
Environmental artist talks science comics, the Gulf of Maine and animal sexuality

In her debut work of nonfiction,‘Poking the Squid,’ Perrin Roosevelt Ireland, artist-in-residence at the New York Aquarium, looks at animal life with a feminist lens.

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Jul 1 • 7:00 AM EDT • Science • pressherald.com
Royals' Jac Caglianone: Returning to Kansas City lineup

Royals' Jac Caglianone: Returning to Kansas City lineup

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Jun 30 • 3:55 PM EDT • Sports • cbssports.com
The Four Business Outcomes That Break When Enterprises Stop Validating Their Defenses - SPONSOR CONTENT FROM AWS AND TERRA SECURITY

Sponsor content from AWS and Terra Security.

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Jun 30 • 3:11 PM EDT • Business • hbr.org
Lebanon County cafe and catering business announces closure

ANNVILLE, Pa. (WHTM) — A local cafe that got its start as a food truck and catering company announced its closure after operating for a decade. abc27 News reported back in February 2025 when …

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Jun 30 • 2:35 PM EDT • Business • abc27.com
Dems join Republicans to crush Tlaib's war powers resolution in lopsided House vote

Rep. Rashida Tlaib's resolution to bar U.S. military hostilities in Lebanon failed overwhelmingly as Republicans questioned why the measure was needed.

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Jun 30 • 1:23 PM EDT • Politics • foxnews.com
Congratulations to the 2026-2027 APSA-Sponsored Congressional Fellows -

APSA is pleased to announce the members of the 2026-2027 Class of the APSA-Sponsored Congressional Fellows! The American Political Science Association (APSA) Congressional Fellowship Program is a highly selective, nonpartisan program devoted to expanding knowledge and awareness [...]

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Jun 30 • 10:00 AM EDT • Politics • politicalsciencenow.com
UFC Power Rankings after UFC Baku

Hello everyone, and welcome back for another week of rankings in the UFC. As we look forward to no fights this week, we were definitely spoiled by the UFC Baku card. There were a few upsets, but none bigger than…

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Jun 30 • 8:53 AM EDT • Sports • sports.yahoo.com
Teen pregnancy prevention cuts hit Wisconsin program connecting health providers and teens

Federal officials have cut off more than $2.4 million in federal funds for 2026-27 and 2027-28 targeting teen pregnancy prevention that would have gone to the Wisconsin health department, according to federal records. The funds would have gone to a variety of nonprofits and agencies in counties with the highest rates of pregnancy and sexually […]

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Jun 30 • 4:30 AM EDT • Health • wisconsinexaminer.com
All eyes on Tom Kean, Capitol Hill’s most mysterious non-voter

The Republican representative will return today, with assurances that he'll explain his absence. Here's what he missed while he was away

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Jun 30 • 12:05 AM EDT • Politics • njspotlightnews.org
Xtalks Launches Life Sciences United (XLSU), a New Global Alliance for Nonprofit Life Science Organizations

Xtalks is pleased to announce the launch of Xtalks Life Sciences United (XLSU), a global alliance and collaborative network designed to bring together nonprofit organizations across the life sciences.

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Jun 29 • 5:03 PM EDT • Science • finance.yahoo.com
West Palm Beach business collecting items for Venezuela

Across the region, donation drives are collecting baby formula, medical supplies, nonperishable food and other essentials for families affected by the disaster.

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Jun 29 • 11:53 AM EDT • Business • wpbf.com
FDLE Relocates Orlando Toxicology Lab to UCF, Strengthening Partnerships and Research

Expansion with the UCF Academic Health Sciences Campus in Lake Nona strengthens the Florida Department of Law Enforcement's forensic opportunities.

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Jun 29 • 11:38 AM EDT • Science • ucf.edu
Red-Pilling Speculation | Los Angeles Review of Books

From Ayn Rand to QAnon, a new anthology explores how reactionary world-building becomes reactionary world-making.

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Jun 29 • 11:00 AM EDT • Politics • lareviewofbooks.org
Supreme Court will weigh Trump-backed Republican push to revive Arizona voting laws

WASHINGTON (AP) — The Supreme Court said Monday it will consider a Republican push to enforce strict Arizona voting laws passed in the swing state after the 2020 election. The high court has allowed some similar rules to take effect temporarily before, including Arizona's proof-of-citizenship requirement for state and local elections and a Virginia purge of voter rolls that the state said was aimed at keeping noncitizens from voting. READ MORE: Supreme Court rejects Trump's

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Jun 29 • 10:13 AM EDT • Politics • pbs.org
Supreme Court to review the legality of mass voter purges in the weeks before an election

The Supreme Court will review the legality of mass voters purges in the final weeks before an election, as part of a larger case the justices are taking up examining the methods Arizona uses to keep non-citizens off the voter rolls.

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Jun 29 • 10:11 AM EDT • Politics • cnn.com
Digital research repository arXiv to start new chapter as nonprofit

On July 1, the digital research respository arXiv, house at Cornell Tech, will transition to an independent nonprofit, enabling faster technological development, expanded partnerships and long-term financial sustainability.

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Jun 29 • 9:13 AM EDT • Science • news.cornell.edu
As medical debt burdens millions, nonprofits and some governments step in

The federal government reversed course on a Biden administration-era plan to block medical debt from appearing on credit reports

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Jun 29 • 9:11 AM EDT • Health • spectrumlocalnews.com
Hayao Miyazaki voice actor Akihiro Miwa dies at 91

Akihiro Miwa has died at age 91. The Hayao Miyazaki voice actor, who played roles in 'Princess Mononoke' and 'Howl's Moving Castle,' was also an iconic singer in Japan.

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Jun 29 • 8:46 AM EDT • Entertainment • ew.com
FAIR Health Price-Informed Tools Support Healthcare Decisions Among Diverse Older Adults

/PRNewswire/ -- Price-informed shared decision-making tools developed by FAIR Health, a national, independent nonprofit, can facilitate meaningful healthcare...

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Jun 29 • 8:36 AM EDT • Health • prnewswire.com
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges

Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy

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Jun 29 • 8:12 AM EDT • Politics • washingtonpost.com
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges

Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy.

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Jun 29 • 8:06 AM EDT • Politics • news4jax.com
Benevolent, manufacturing facilities: See 20 latest business, apartment, land sales ($30K to $1.4M)

See a list of property sales in Onondaga County other than residential homes.

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Jun 29 • 7:07 AM EDT • Business • syracuse.com
This Baker’s Business Is Booming (and It’s Not Just Because of the Cannon Fire)

Justin Cherry’s breads are in demand this semiquincentennial, as is his knowledge of historical baking methods.

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Jun 29 • 5:02 AM EDT • Business • nytimes.com
49ers Insider Delivers Commanders Blunt Reality on Brandon Aiyuk

The Washington Commanders are a side character in the rift between Brandon Aiyuk and the San Francisco 49ers. In recent days, Aiyuk has made it clear that he wants to play for the Commanders.Before the remarks from Aiyuk, there was only reporting of Washington’s interest in the 49ers’ wideout. Nonetheless, that’s slightly changed with the […] The post 49ers Insider Delivers Commanders Blunt Reality on Brandon Aiyuk appeared first on HEAVY.

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Jun 28 • 6:36 PM EDT • Sports • sports.yahoo.com
After budget impasse, business as usual for Virginia Democrats, analysts say

This has been a budget battle like none other, with big personalities, personal attacks and what looked like a high-stakes game of chicken with days to go before the Virginia state government couldn’t pay its bills.

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Jun 28 • 4:37 PM EDT • Business • pilotonline.com
Pennsylvania measles outbreak tops 70 cases as health leaders pledge to get spread ‘under control’

The most recent measles outbreak started in the area of Lebanon and Lancaster counties in late April. Cases now span six counties.

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Jun 28 • 3:14 PM EDT • Health • whyy.org
Executive Summary: Slowing down, listening a part of Gehrig’s leadership

Editor’s note: The Fort Smith Metro Daily News Executive Summary series is focused on looking under the title, so to speak, of a business, government, and non-profit executive in the...

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Jun 28 • 1:33 PM EDT • Business • talkbusiness.net
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Royals' Jac Caglianone: Managing groin issue

Royals' Jac Caglianone: Managing groin issue

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Jun 28 • 12:10 PM EDT • Sports • cbssports.com
Mel Brooks turns 100: His 5 essential movies

As Mel Brooks turns 100 today, here are the 5 must-watch comedies from his hilarious canon of work.

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Jun 28 • 9:22 AM EDT • Entertainment • ew.com
UVA Health finding continuing issues with counterfeit child safety seats in vehicles

It's buyer-beware as it's not illegal to sell FMVSS non-compliant seats

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Jun 28 • 6:45 AM EDT • Health • cvillerightnow.com
San Antonio Pride festival celebrates LGBTQ+ community, raises money for local nonprofits

Thousands of people were expected at Crockett Park on Saturday for the Pride Bigger Than Texas Festival, an eight-hour celebration of LGBTQ+ history, resilience and community support.

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Jun 27 • 7:31 PM EDT • Entertainment • ksat.com
How AI-Powered Public Comments Are Entering US Climate Politics

Officials have been confounded by the new phenomenon.

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Jun 27 • 11:59 AM EDT • Politics • bloomberg.com
Why didn’t Arsenal’s Saliba play against Norway?

France eased past Norway to top their World Cup group on Friday night, but William Saliba was unavailable for the game as he continues to manage his back injury.Photo by Darrian Traynor/Getty ImagesFr...

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Jun 27 • 7:05 AM EDT • Sports • sports.yahoo.com
Marseille look to retain three players

Get French Football News understands that every player at Olympique de Marseille – bar none – is available for the right price this summer. The club overspent under Roberto De Zerbi and the purse...

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Jun 27 • 6:55 AM EDT • Sports • sports.yahoo.com
Trump admin rule puts reproductive health care for 160K Pa. patients at risk, lawsuit says

Spotlight PA is an independent, nonpartisan, and nonprofit newsroom producing investigative and public-service journalism that holds power to account and...

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Jun 27 • 6:00 AM EDT • Health • post-gazette.com
Will Cannon posts second-round 61, leads Memorial Health Championship presented by LRS

Will Cannon grabs a one-shot lead through 36 holes at the Memorial Health Championship presented by LRS after posting a 10-under 61 on Friday.

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Jun 26 • 9:18 PM EDT • Health • pgatour.com
KATSEYE addresses speculation over Manon's future with group

KATSEYE is asking fans for patience as Manon Bannerman's health-related hiatus stretches into its fifth month.

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Jun 26 • 6:52 PM EDT • Entertainment • centraloregondaily.com
Is the No Surprises Act working? Government watchdog is uncertain

The nonpartisan Congressional Budget Office said it needs more data to determine what savings the 2020 law is bringing to the U.S. healthcare system—but early data indicate it falls short of expectations.

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Jun 26 • 5:24 PM EDT • Health • healthexec.com
Pete Buttigieg was briefly separated from his children after police say he was target of false report

Former Transportation Secretary Pete Buttigieg was the target of an anonymous report that police determined was false and that he says forced him to spend a night away from his four-year-old twins.

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Jun 26 • 4:22 PM EDT • Politics • cnn.com
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Congress subpoenas Leon Black during interview about Jeffrey Epstein

The House Oversight Committee issued subpoenas to billionaire Leon Black after he declined to answer questions about non-disclosure agreements.

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Jun 26 • 2:33 PM EDT • Business • businessinsider.com
Kristen Stewart and Alia Shawkat are 'The Wrong Girls' in first look at new stoner comedy (exclusive)

EW has your exclusive first look at the stoner comedy 'The Wrong Girls' from writer-director Dylan Meyer, starring Kristen Stewart, Alia Shawkat, LaKeith Stanfield, Seth Rogen, and Kate McKinnon.

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Jun 26 • 1:00 PM EDT • Entertainment • ew.com
Kristen Stewart and Alia Shawkat are “The Wrong Girls” in first look at new stoner comedy (exclusive)

LaKeith Stanfield, Seth Rogen, Kate McKinnon, and Geena Davis also star in the Neon film.

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Jun 26 • 1:00 PM EDT • Entertainment • yahoo.com
SGMC Health Honors White with BEE Award

SGMC Health recognized Jessica White, patient care technician on 4 South, as the June recipient of the Being Extraordinary Everyday (BEE) Award, which honors non-nursing staff who demonstrate exceptional compassion, collaboration, and dedication to patient care.

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Jun 26 • 11:22 AM EDT • Health • sgmc.org
Why Your Nighttime Dreams Are So Weird—Science Finally Has the Answer - Futura-Sciences

The Secret Life of Dreams: Not Just Random Nonsense Remember the dream you had last night? Maybe you’re left with just a trace—a sweet feeling, maybe, or a strange discomfort. But there’s rarely a story you could actually retell. Because, in the end, a dream is a deeply personal experience....

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Jun 26 • 10:30 AM EDT • Science • futura-sciences.com
Nonprofit aims to help displaced workers as businesses adopt artificial intelligence
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Jun 25 • 6:20 PM EDT • Business • pbs.org
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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Transcription by Ben Lerner wins Orwell prize for political fiction

Judging chair calls Lerner’s novel a ‘funny, brainy and timely’ study of our appetite for technology, while Karen Bartlett wins the nonfiction prize for The Escape from Kabul

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Jun 25 • 4:15 PM EDT • Politics • theguardian.com
North Carolina, Illinois basketball to meet at Bridgestone Arena

Six non-conference, neutral-site contests on tap for downtown Nashville facility in 2026-27 season

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Jun 25 • 1:30 PM EDT • Sports • nashvillepost.com
Poppi founder speaks about building a billion-dollar soda business

Allison Ellsworth, the founder of the viral soda brand Poppi, sits down with NBC News' Savannah Sellers to discuss how she turned a personal health issue into a billion-dollar cultural phenomenon.

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Jun 25 • 11:26 AM EDT • Business • nbcnews.com
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Longtime Entertainment Industry Lawyer Joins Royalties Retriever SoundExchange

Michele Page, formerly of Peloton Interactive, arrives at a pivotal time for the nonprofit reeling from a court ruling that may impair its ability to sue on behalf of artists.

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Jun 25 • 11:13 AM EDT • Entertainment • law.com
Their Family Business Went From Bankruptcy to a $4 Billion Snack Empire: Inside Jack Link’s Wild Entrepreneurial Ride

Meat, risk, and NASCAR — here's how Jack Link's CEO Troy Link has grown his family business into a global phenomenon.

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Jun 25 • 10:00 AM EDT • Business • entrepreneur.com
David P. O'Brien

About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.

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Jun 25 • 9:03 AM EDT • Business • crainscleveland.com
CVS Health Foundation invests $1 million in Rhode Island nonprofits tackling community health needs

/PRNewswire/ -- The CVS Health Foundation is investing $1 million in grants through its Hometown Fund to 20 organizations that are making a difference for...

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Jun 25 • 9:00 AM EDT • Health • prnewswire.com
How should European scientists respond to the US AI kill switch?

Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.

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Jun 25 • 8:00 AM EDT • Science • sciencebusiness.net
What are the best businesses in Centre County? Submit your nominations to CBICC

Your input can help recognize a deserving local business or nonprofit organization.

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Jun 25 • 5:13 AM EDT • Business • centredaily.com
CVS Health Foundation invests $1 million in Hartford nonprofits tackling community health needs

Local organizations receive Hometown Fund support to expand access to health care, food, housing and essential services

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Jun 25 • 3:00 AM EDT • Health • cvshealth.com
Louisville doctor, nurse and nonprofit founder charged in federal health care fraud crackdown

Federal prosecutors in the Western District of Kentucky announced charges in four separate cases involving alleged schemes to defraud Medicare and Medicaid, misuse medical credentials and controlled substances, and submit

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Jun 24 • 10:30 PM EDT • Health • wdrb.com