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Fantasy Football Video: Will managers be able to trust Seahawks rookie RB Jadarian Price?
Contract details for New York Giants GM Joe Schoen revealed
Details about the contract extension given to New York Giants general manager Joe Schoen have been revealed.
Simeone Breaks Silence On Talks With Barcelona Target Julian Alvarez
Atletico Madrid manager Diego Simeone has revealed talks he recently held with FC Barcelona target Julian Alvarez in the United States.
Roma, Basel reach agreement over Calafiori’s resale clause
Riccardo Calafiori is one of the players who emerged from Roma’s youth system and has managed to establish himself on the big stage. The former Giallorossi defender won the Premier League with Arsen...
Hossam Hassan and the blurring of lines between football and politics in Egypt
Egypt face Australia in a historic World Cup game on Friday and the manager has been keen to highlight president Al-Sisi’s role in the achievement
Saving science as we know it: Overview of new proposed rule from the Office of Management and Budget, and how we can make our voices heard.
The Office of Management and Budget has proposed to completely restructure federal funding for science as we know it. In this bite, we review the most relevant points in the proposal and describe how to submit public comments on it by the deadline of July 13th, 2026.
Cincinnati nightclub announces closure despite success; safety risks became 'too great'
Sharks Nightclub is closing its doors, not because business was struggling, but because its former manager says the safety risks had become too great.
Thousands need medical attention from ‘already overwhelmed’ Venezuelan healthcare system: Aid worker
Claudia Manresa, Venezuela Regional Manager at Project HOPE joins Meet the Press NOW to discuss the urgent humanitarian situation following last week’s twin earthquakes and the strain the disaster is putting on the country's already struggling systems.
Sports Help Shape Young Lives. Trans Kids Deserve That Chance.
By Lambda Legal Senior Content Manager Lake Geslani When Becky Pepper-Jackson laced up her running shoes, she wasn’t thinking about court cases or political debates. Like countless young athletes across the country, she simply wanted to be part of a team, compete alongside her friends, and proudly represent her school. Instead, Becky found herself at...
Opinion | Trump administration move poses an existential threat to science
"The new threat can be found in the 412-page proposed rule from the Office of Management and Budget," two professors emeriti write. "It seeks to put all federal funding decisions, for science and non-science, in the hands of political appointees with no expertise."
HHSC Announces Upgraded WIC Cards for Families | Texas Health and Human Services
HHSC launched upgraded WIC EBT cards integrated with the myWIC app to help Texas families manage, track and secure their benefits more easily.
What’s going up on Airline Highway, near Coursey Boulevard?
The first phase of construction started in May, according to a Facebook post by Centurion Construction Management, the general contractor.
What Makes Live Nation Entertainment (LYV) a Good Investment Bet?
TimesSquare Capital Management, an equity investment management company, released its “U.S. Mid Cap Growth Strategy” first-quarter 2026 investor letter. A copy of the letter can be downloaded here. The Strategy fell 7.72% (net) in the quarter compared to -6.35% for the Russell Midcap Growth Index. In the first quarter, markets navigated geopolitical tensions and economic resilience alongside […]
Manage Your Business Projects Like a Pro With Microsoft Project 2024
This lifetime license to the full Professional version is on sale for a one-time $49.97.
Croatia criticised for ‘unambitious’ changes to 2022 science law
Croatia’s science ministry has been accused of a lack of ambition, and even incompetence, over proposed changes to the country’s 2022 science law. Critics say an opportunity has been missed to fix wider shortcomings in the research and universities system.“This law, like all the previous ones, will not significantly change the current state of science in Croatia,” Vlatko Silobrčić, a member of the Croatian Academy of Sciences, told Science Business. “A small shift here and there will not have a significant impact.”The 2022 law introduced multi-year block grant financing of research, based on results, and changes intended to boost employment and career progression for researchers and lecturers. But implementation of the law has been uneven. “It became apparent that certain of its provisions were subject to different interpretations by higher education institutions and scientific institutes,” the science ministry said in its proposal for change. “This caused legal uncertainty in the system, administrative difficulties in implementation and, in certain cases, unequal treatment of teachers, scientists and students.”Most of the proposed amendments deal with technicalities in hiring and promoting staff, such as extending the committee deadlines from 60 to 90 days, or allowing applicants to cite all of their achievements and not only those since their last appointment.Both the ministry and Croatian media highlighted changes that would raise the retirement age from 65 to 67 years and allow part-time students 15 year rather than 10 years to finish their studies.The change to retirement age has been criticised for reinforcing a weakness in the system. According to Matko Marušić, professor emeritus at the University of Split, this will “allow unproductive teachers to advance and work longer, while hindering and discouraging productive ones.”A longtime campaigner for excellence-based meritocracy, he sees little hope in the new legislation. “I am not optimistic that things will improve,” he told Science Business. “As recent changes to the law in Croatia show, the legal framework is becoming increasingly hypocritical and harmful.”For Marušić, who analyses Croatia's university system in a recently published book, the situation is “unfavourable and constantly deteriorating” due to the criteria used for academic advancement.“The key criterion for advancement should be scientific productivity,” he said. “In Croatia [. . .] scientific criteria are increasingly lowered, and ineffective and absurd criteria such as waiting times for promotion and age limits for remaining in a job are promoted.” He would also like to see better criteria for the quality of teaching at universities. “In practice, teaching is not monitored or evaluated,” he said, estimating that up to a third of teaching simply does not take place. “Under the guise of university autonomy and bad laws, universities and faculties are allowed to earn additional money by increasing enrolment quotas that have nothing to do with the needs of the labour market.” Lack of ambitionDora Kršul, a reporter at Telegram.hr who covers science policy in Croatia, finds the rationale for changes “bizarre.” “The ministry responsible for supervising the uniform application of the law is changing the law because it is being implemented unevenly,” she said. “This primarily speaks to the power relationship in the sphere of science and higher education in Croatia, that is, the question arises as to who actually manages this system.”Rather than raising quality, she continued, the changes appear to be designed to help vocational and applied universities who have not been complying with the law.The Independent Union of Research and Higher Education Employees of Croatia said that the changes were “unambitious” and represent a missed opportunity for more important changes. “We think some of the changes are even negative,” it said in its statement on June 25. One of these is introduction of an “assistant” job title that allows people to be hired only for the duration of a project. Related articles: Elections to top science bodies test Croatia’s gender equality in researchSlovakia revises R&D approach to increase focus on competitivenessLatvia pilots citizen engagement in research grant evaluationsThe union’s president, Tvrtko Smital, who was part of the 15-member working group tasked with drafting the changes, told the local media there was a “worrying lack of ambition” in the process, and “lack of competence” in terms of research experience and understanding the problems in the system.“There is no clear will to deal with the problems,” said Smital, an assistant professor of marine and environmental sciences at the Ruđer Bošković Institute in Zagreb. “It’s a combination of unambitiousness and incompetence,” he went on, expressing his “deep frustration” with the situation. “There is no strategy, no clear thinking, and money is not being spent optimally.”Croatia’s science ministry has not responded to requests for comment.
Minor League Update: Rookie Leagues
Whenever I give updates on minor league stats, I’m always conflicted about how many players to include. Some of it is time management-related. Obviously, if I cover every conceivable player, it will take me time I sometimes don’t have. But I also am not particularly interested in writing 5,000 words for one of these either. […]
Dodgers Give Devastating Update on Will Smith
Dodgers catcher Will Smith's neck is not getting any better, according to manager Dave Roberts, and his return is looking longer overall.
Athletics slugger Brent Rooker to have season-ending knee surgery
Athletics designated hitter Brent Rooker will undergo surgery to repair a cartilage tear in his left knee and miss the remainder of the season. “This is a big blow,” manager Mark Kotsay said Wednesday before the A's played the Los Angeles Dodgers. A two-time All-Star, Rooker hasn’t played since June 8.
CEO says his fund is investing in Netflix, sees ‘risky business’ in chips
Infrastructure Capital Management CEO Jay Hatfield says Netflix is showing good growth despite being ‘double hammered’ on ‘The Claman Countdown.’
South Coast Business & Technology Awards Raises More Than $200,000 for Scholarship Foundation
William Wang, Mission Wealth, and UCSB Dept. of Technology Management among the honorees
Artists First Launches Music Division Led By Entertainment Exec Carmen Murray
Talent management and production company Artists First announced the launch of its Music Division and the hiring of veteran entertainment executive Carmen
United sign 'calm and composed' goalkeeper Amissah
Former Ross County goalkeeper Jordan Amissah has returned to Scotland to provide a "calm and composed" presence at Dundee United, says manager Jim Goodwin. The 24-year-old has agreed a two-year deal at Tannadice following his exit from Burton Albion. Amissah impressed during a six-month spell at County before heading back south of the border.
Jacqueline Mosher Joins Industry Entertainment (EXCLUSIVE)
Manager Jacqueline Mosher has joined Industry Entertainment after seven years at Rain Management, Deadline can tell you first.
Manager Jacqueline Mosher Joins Industry Entertainment
EXCLUSIVE: Manager Jacqueline Mosher has joined Industry Entertainment. Mosher works with a mostly literary-focused client base across film and TV and comes to Industry after seven years at Rain Manag...
Experity acquires AI firm to automate urgent care revenue management
The move by the Machesney Park-based Experity is meant to accelerate revenue cycle management automation through artificial intelligence.
Army experimenting with mobile business apps
The events are also revealing where industry is building redundant software, the Army said.
From Business Idea to Launch: Inside Babson’s New Online MSBC Degree · Babson Thought & Action
Professor Richard Hanna explains how Babson’s new online Master of Science in Management in Business Creation helps aspiring entrepreneurs build launch-ready businesses.
ACCESS Model: behavioral health edition
A new value-based care program for chronic condition management begins July 5. | A new payment model is designed to pay digital health companies based on outcomes in chronic condition management. But where does behavioral health fit? This episode explores that question with SonderMind and Headspace, two companies participating in the model's behavioral health track.
Meta to sell excess AI computing capacity via cloud business, Bloomberg News reports
At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life.
The Case for Performance-First Management
What began as a crisis-driven response to the Covid pandemic laid the foundation for today’s dominant management paradigm: people-first management. But today’s business demands a different approach, as performance and productivity have replaced engagement and retention atop the CEO agenda. Performance-first management represents a gentle shift toward an approach where managers empower their teams to deliver high-impact results within a complex and evolving reality. It keeps people at the center, but reorients the manager’s role around enabling performance, not just supporting satisfaction. Gartner research shows that managers who shift toward a performance-first approach are up to 21% more likely to deliver the business results that are expected of them. And employees who say that their managers are performance-first report higher overall satisfaction with their employee experience.
How the Supreme Court just rewrote the rules of politics
After years of political party power players like Senator Mitch McConnell trying to take control of national party purse strings to which candidates to help and how to shape the party, all it took was one ruling by the Supreme Court to change the way campaign politics is funded. Jen Psaki talks with Jim Messina, former campaign manager for President Barack Obama about how the Supreme Court's ruling changes the game in terms of how political donations are spent.
How Wisconsin Used Foxes And Deer To Revamp Science Education
Public input identifying over 100 million trail cameras photos of Wisconsin’s animals has transformed science education and state wildlife management.
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
Microsoft to cut under 2.5% of workforce in latest layoffs, Business Insider reports
At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life.
Women with PMOS should have yearly NHS checks, says health watchdog
Despite affecting millions of women in the UK, PMOS is still under-diagnosed and inconsistently managed, say experts.
Women with irregular periods should be checked for PMOS, NHS says
Polyendocrine metabolic ovarian syndrome is underdiagnosed and inconsistenly managed, according to Nice
Portfolio manager says Amex is en route to a huge chunk of business from travelers
Advisors Capital senior portfolio manager Gus Scacco discusses the Dow’s record close and some under the radar stocks on ‘The Claman Countdown.’
Members-only club Common House is under new management as operator withdraws after 2 years
Common House has withdrawn from all four of its clubs over the past three months.
Anthropic unveils 'Claude Science' AI platform for scientific research
Anthropic on Tuesday launched Claude Science, an AI platform designed to help scientists streamline research, analyze data and manage complex computing workflows.
Contract extension marks 'fresh start' for Taylor
Midfielder Fraser Taylor is relishing a "fresh start" under new St Mirren boss Craig McLeish after signing a two-year contract extension. The 23-year-old academy graduate, whose deal now runs to summer 2028, made his first-team debut in 2022 and featured 13 times for the Buddies last season before joining Partick Thistle on loan in January. "I'm really pleased, since the new manager has come in, he spoke to me on the off-season, and his ideas really suit the way I like to play," said Taylor.
Marlee Matlin Signs With Gilbertson Entertainment (EXCLUSIVE)
Academy Award winner Marlee Matlin ('CODA') has inked with Gilbertson Entertainment for management.
VA Primary Care adds virtual reality to Veterans’ Mental Health Toolkit
Virtual reality devices help Veterans by offering additional ways to manage issues affecting their physical and mental health.
Deutsche Bank sells India retail business to Kotak Mahindra
Deutsche Bank said on Tuesday that Kotak Mahindra Bank would acquire its Indian retail banking and wealth management business in India.
Bruno Genesio agrees two-year Marseille contract
Bruno Genesio is set to put pen to paper over a two-year deal as Marseille manager, according to a report from L’Equipe. The former Lille OSC head coach was identified by Les Phocéens as the ide...
A.I. takes center stage in health topics discussed at the Aspen Ideas festival
Right now, some of the world's brightest leaders, scholars and artists are in Colorado for the Aspen Ideas festival. NBC News’ Kate Snow went to discuss how A.I. Is reshaping the classroom and how we manage our health.
Private Equity-Backed IT Business TPx Files for Bankruptcy to Sell Assets
The managed information-technology services company has a restructuring agreement with its sponsor and the majority of creditors.
Jessica Blair Herman Signs With Luber Roklin Entertainment (EXCLUSIVE)
Actress Jessica Blair Herman has inked with Luber Roklin Entertainment for management, Deadline can report exclusively.
Eskin named general manager of NEXUS sports and entertainment complex
Middlesex County, in partnership with The Sports Facilities Companies, announced Edison native Katie Eskin as General Manager of NEXUS.
Congress wants to ban AI companies from selling your health data
The new proposal bans selling health and location data info — including data entered into your favorite AI chatbot.
Ahead of the MLB trade deadline, here’s where the Yankees stand
Yankees general manager Brian Cashman is almost always aggressive when he believes in his team.
The role customer relationship management plays in small business growth and efficiency
Nutshell reports that small businesses benefit from CRM systems, improving customer retention and sales, while starkly contrasting with larger firms' efficiency.
Ex-boss Foyle returns to Port Vale as chief scout
Former Port Vale player and manager Martin Foyle returns to the League Two club as its chief scout.
ACE WFM Strengthens Workforce System Delivery Approach for Australian Organisations
Melbourne, AUSTRALIA, June 29, 2026 (GLOBE NEWSWIRE) -- ACE WFM, a workforce management consulting provider, has outlined its structured approac...
Jose Mourinho eyes Chelsea mainstay as his ‘priority’ signing
Former Real Madrid manager Xabi Alonso has taken over the reins as Chelsea’s new coach and is already planning the squad and his dynamics for the upcoming season.The revolutionary thinker that he is...
Reece James: England defender confident of playing again at World Cup
Plus: England face prospect of 24 hours worth of flights if they make it all the way to World Cup final; South Korea manager Myung-Bo Hong reportedly quits after disappointing tournament; Robert Lewandowski to join Chicago Fire after leaving Barcelona
Then and Now: Brandenburg manages through global uncertainty
For James Brandenburg, president of U.S. operations for JVS Export, a family-owned textile manufacturer headquartered in India, the hardest part of his job isn’t selling home textiles to Walmart, Target...
Assenagon Asset Management S.A. Decreases Stock Holdings in Live Nation Entertainment, Inc. $LYV
Assenagon Asset Management S.A. lessened its stake in Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) by 77.4% in the 1st quarter, according to the company in its most recent Form 13F filing with the SEC. The fund owned 74,497 shares of the company's stock after selling 254,802 shares duri
38,599 Shares in Caesars Entertainment, Inc. $CZR Bought by 1492 Capital Management LLC
1492 Capital Management LLC purchased a new stake in shares of Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the first quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The institutional investor purchased 38,599 shares o
New packaging for Apple's A20 Pro chip should keep the iPhone 18 Pro series feeling cool
With everyone worried about chips and phones heating up, processors are getting improved thermal management tools.
UAPB School of Business and Management celebrates class of 2026
The School of Business and Management (SBM) at the University of Arkansas at Pine Bluff recognized the achievements of its graduating Class of 2026 during its annual Graduates Banquet recently at the STEM Conference Center. The event, coordinated by Cynthia Sims, SBM project/program specialist, brought together students, faculty, administrators, alumni, family members and supporters to […]
Black Canyon City business defrauded by GM
A woman was arrested Tuesday for allegedly stealing $40,000 from the Black Canyon City business for which she was the general manager.
States seek to lower drug prices by targeting the companies that manage them for health plans
TOPEKA, Kan. — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting
City of Palms new downtown parking program: How local business react to the change
The Fort Myers City Council recently approved a change impacting parking rates at all three of downtown Fort Myers' parking garages. As it stood, visitors would receive one hour of free parking followed by a hourly rate. Now, the change has made it so visitors are entitled to two free hours followed by a hourly rate. Local business owners and managers said it's a good idea giving visitors more time to bask under the royal palms and indulge in some shopping. But one general manager points out a problem that did not start yesterday, but years prior.
Angels fire g.m. Minasian
The Anaheim Angels fired general manager Perry Minasian on Friday
What scientists discovered about coffee grounds will transform construction industry - Futura-Sciences
At the start of 2024, a study published several months ago is once again drawing attention. Scientists at RMIT University in Australia have identified an unexpected use for spent coffee grounds, opening the door to a promising solution for both the construction sector and organic waste management. From coffee waste...
Why didn’t Arsenal’s Saliba play against Norway?
France eased past Norway to top their World Cup group on Friday night, but William Saliba was unavailable for the game as he continues to manage his back injury.Photo by Darrian Traynor/Getty ImagesFr...
Perplexity, Kalshi, Replit insiders share how to get a startup job
We asked startup founders, recruiters, and hiring managers what to do — and not to do — to boost your chances of getting an offer.
CARE AT HOME GUARANTEE CORPORATION FILES PATENT APPLICATION FOR PROPRIETARY BUSINESS MANAGEMENT SYSTEM
Miami, FL, June 27, 2026 (GLOBE NEWSWIRE) -- CARE AT HOME GUARANTEE CORPORATION ('the Company'), a Florida-based Senior Care Solutions company, ...
Messi to start final Argentina group match on bench
World Cup top scorer Lionel Messi will start Argentina's final group match against Jordan on the bench, manager Lionel Scaloni confirms.
Dave Roberts Gives Update on Rushing’s Future Catching Ohtani
Dodgers manager Dave Roberts elaborated on what the plan is for catcher Dalton Rushing after his rough night with Shohei Ohtani pitching.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Americans keep poisoning themselves with semaglutide, other weight loss drugs
These incidents became much more common after the FDA started approving GLP-1 drugs for chronic weight management in 2021.
His Fortune’s From the Trash Business. His Basquiats Are Priceless.
In the last few years, waste-management billionaire Patrick Dovigi has become one of the biggest art collectors on the scene. But he’s still under the radar—maybe the shots fired on his home have something to do with that.
General manager arrested for stealing over $40,000 from Black Canyon City business
An investigation found that financial records had been deleted, documentation was incomplete and deposits were missing.
Elisee Junior St. Preux Signs With Evoke Entertainment (EXCLUSIVE)
Filmmaker Elisee Junior St. Preux has inked with Evoke Entertainment for management, Deadline can report exclusively.
Foundation Friday: Building bright futures & mental health through fitness
The Lift US Foundation and InnerCity Weightlifting empower people to strive for better lives through fitness.
Andy Cohen cries as he mourns 28-year-old 'WWHL' producer who died of brain cancer
Andy Cohen became emotional mourning 'Watch What Happens Live' production manager Kyra Samson, 28, who died of brain cancer earlier this week.
Michael T. Cooney and Matthew Quinlan
Calamos Wealth Management announces the addition of two seasoned wealth management professionals. Michael T. Cooney joins the firm as a SVP, Senior Wealth Advisor, and Matthew Quinlan joins as a Wealth Advisor.
Warren Buffett Bought A Business For $1.7B ‘Over The Phone Without Ever Meeting The People There’ Using The ‘Most Valuable Skill’ He Learned
Buying a company for $1.7 billion without meeting management sounds like the kind of decision that would keep lawyers busy for months. Warren Buffett did it over the phone. Speaking at the University of Nebraska-Lincoln in 2003, Berkshire Hathaway Chair...
PNC Business Credit Names Brady to Southwest Region Sales Manager
PNC Business Credit promoted Eamonn Brady to Southwest region sales manager. Based in Denver, Brady will spearhead business development efforts across both
TravelTech Show, Business Travel Show Europe name 2026 innovation award winners
Arcube, ImpersonAlly, Acai and Nowadays were recognized in separate competitions for travel technology innovations spanning airline retailing, brand protection, contact center automation and meetings management.
How to manage public investment in science with balance
Public debt is higher today and growing at a faster rate than before the pandemic in 80% of the world's economies. According to the latest fiscal report from the International Monetary Fund, global public ...
New York state launches center for cannabis care and health
The state Office of Cannabis Management on Thursday announced the launch of its Center of Excellence for Cannabis Care and Health Equity.
Project manager says America’s Time Capsule is a ‘gift to the future’
The vessel will move from Washington to Philadelphia starting Friday.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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