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CSUN in D.C. Internship Expands Student’s Public Health Career Aspirations
For Josiah Morrow, a three-month internship in Washington, D.C., turned the nation’s capital into a classroom — and helped shape his future in healthcare.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
James Gunn dispels Wonder Woman casting rumors while roasting Frank Grillo
James Gunn addressed the Adria Arjona-Wonder Woman casting rumors by roasting DC star Frank Grillo. ‘You don’t believe he doesn’t know anything? Exhibit A.’
The UNC Sports Week Ahead: October 5th-11th
It’s a quiet week for UNC sports… Until it isn’t. Following a busy weekend, most of the UNC sports in action take a break until the weekend. Then during the weekend, you’ll have a lot of options for watching the Tar Heels play. This also includes a pretty big debut. UNC Basketball Yes, the regular […]
Will R.I. voters, elected officials continue investing in life sciences?
Rhode Island starts in a strong position and has the ingredients needed for innovation and growth. What we don’t have yet is a long-term commitment, writes the CEO of the RI Life Science Hub.
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Layla Zaidane: The politicians who can fix America’s polarization problem will win
Political predictions are notoriously unreliable, but here is one I am willing to stand behind: the elected officials who figure out how to govern across difference will dominate the next decade of American politics. With dysfunction and paralysis having become the status quo in Washington, elected officials who work together
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Police urge Pennsylvania businesses to remove skill games as legal deadline approaches
Months after a justice ruled that skill games are legally slot machines, a deadline is fast approaching for the machines to be removed.
Orlando Science Schools begins enrollment process for six regional campuses
Orlando Science Schools is accepting applications for 2027-28, including new 11th grade spots at Seminole Science.
Congressional candidates discuss expanding executive power and need for political will
Congressional approval ratings are in the tank. By some measures this is one of the least productive sessions of Congress in living memory. WGLT's Charlie Schlenker reports those things may not change much any time soon.
Did Jaguars' Pass Rush Turn a Corner in Sunday's Victory?
The Jacksonville Jaguars had their most productive pass-rushing game of the season in Sunday's victory, with the EDGE pair of Josh Hines-Allen and Travon Walker leading the way.
Justin Bibb’s new Blue Cities/Red States coalition seeks the ‘radical center’
Cleveland Mayor Justin Bibb is launching Blue Cities/Red States, a 15-mayor coalition aimed at showing Democrats can govern effectively even when Republicans control their statehouses.
Dungeons and Dragons: World of Warcraft – Everything You Need to Know
Dungeons and Dragons: World of Warcraft was announced way back in July, as the first Universes Beyond release for the storied tabletop RPG. And just like the MMO it's based on, D&D: World of Warcraft is absolutely massive.
Olivia Rodrigo’s Unraveled tour might be 2026’s best
WASHINGTON – For her third major tour, Olivia Rodrigo literally brought herself some well-deserved flowers.
‘Primetime’: Is catching predators justice or just entertainment?
Rating: ★★★½ Starring Robert Pattinson, Skyler Gisondo, Merritt Wever Directed by Lance Oppenheim Rated R Release Date: Sept. 25, 2026 A man waits unknowingly inside a sting house. His eyes draw up to the sound of curtains ruffling as Chris Hansen (Robert Pattinson), host of Dateline NBC’s “To Catch a Predator,” enters flamboyantly. Hansen descends...
"I think just with the playoff time and watching, that …
"I think just with the playoff time and watching, that …
Washington Capitals star Alex Ovechkin announces this is his final NHL season
He broke Wayne Gretzky's career goal-scoring record in April 2025
Behind the Seams | Wildwood
Go behind the scenes at LAIKA Studios for an up-close look at the extraordinary costumes of ‘Wildwood,’ the studio’s most intricately designed stop-motion film yet. Nearly 20 years after ‘Coraline,’ LAIKA’s artists and designers reveal how every tiny stitch, button and layer of fabric is handcrafted and engineered to help bring its puppets to life, combining costume design, fabrication and animation at an astonishing scale.
Barcelona superstar set for salary raise as per prior agreement
Lamine Yamal’s start to the new season has been astonishing, and the player is operating at a level that any normal teenager should not even be able to dream of.He is, at this point, one of the best...
Netflix’s #1 Movie Has Viewers Ugly Crying
Netflix’s #1 movie is leaving viewers reaching for the tissues. Find out more here.
Can we harness the brain's deep-cleaning system to prevent Alzheimer's?
The glymphatic system is the brain's recently discovered network for flushing out toxins. Now, we're uncovering surprising ways to boost it to protect brain health
New Apple TV 4K launches next week with two major upgrades
New Apple products are reportedly launching October 13, including an updated Apple TV 4K with two major upgrades rumored.
Dawg Sports on the Radio
Your Georgia Bulldogs defeated the Vanderbilt Commodores 38-14 on Saturday, and we intend to not just write about it, but also talk about it. That’s why I’ll be listening to MaconDawg’s chinchilla ranching consultant on WFOY in St. Augustine(102.1 FM/1240 AM) this evening around 6:45 pm Eastern to talk Georgia Bulldog football on SportsNow with host […]
Offensive Line Looks Offensive: Spartans Rank Last in Sacks Allowed
From personnel shifts to coaching failures, a crumbling front wall has left the Spartans reeling as record-breaking sack numbers threaten to derail the Pat Fitzgerald era.
Davids Fights Washington Healthcare Cuts with Plan to Lower Costs, Protect Kansas Hospitals
WASHINGTON, D.C. — Today, U.S. Representative Sharice Davids (KS-03) introduced a comprehensive package of healthcare legislation that directly counters Washington’s recent healthcare rollbacks, which are increasing monthly costs and closing rural hospitals. Davids’ efforts would protect Kansas families from rising medical costs, block new federal red tape, and keep local hospitals and health clinics open.
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
Is a front office-coaching divide hurting the Steelers?
Is a strategic divide between Omar Khan's front office and Mike McCarthy's coaching staff creating an identity crisis for the Steelers?
What does Spain's snap election mean for the EU?
Spain's snap election on 29 November could cost progressive European forces their last government in a large member state, tilting EU power towards the right and pushing socialists into opposition mode.
US services sector activity slows in September; price pressures mount
US services sector activity slowed in September, with strong domestic demand stretching supply chains and raising prices paid by businesses for inputs, indicating that inflation could remain high into next year.
Inspired By My Love Of STEM, I Collaborated With 22 Teens To Write A Kids Picture Book About Science
Teen STEM student Eliana Miao wrote a picture book about the microbiome and empathy titled "The Brave Fuzzy: A Microbiome Story"
Nobel for medicine awarded to 3 scientists for work that helps map the brain
A method that controls nerve signals with light, developed by an American and two Germans, has provided greater understanding of Alzheimer’s and is used in efforts to restore sight.
Pixel 12 series leak allegedly reveals model numbers, display specs, no wide Fold
A new leak allegedly reveals Pixel 12 display specs, model numbers, and helps confirm Google isn't launching a wide Fold.
Gambit's Election Guide Fall 2026
This fall’s elections are fast approaching. Early voting starts Oct. 20 and will run through Oct. 27 (excluding Sunday, Oct. 25), and Election Day is scheduled for Nov. 3.
Top crypto group to pour millions into bipartisan slate of House races after key legislation stalls
WASHINGTON (AP) — A top cryptocurrency campaign organization is unveiling a bipartisan list of House members that it will support in the November midterms, as o
Seattle-area businesses feel sting of ‘obscene diesel prices’
In Washington, the average cost for a gallon of diesel was around $7.37 Friday, according to the American Automobile Association, almost $2.50 more than a year ago.
Nations League: the chances of reaching the quarter-finals 👀
Are Les Bleus in a strong position?In this edition of the Nations League, as in the previous one, the group stage will be followed by quarter-finals.The top two teams in each of the four groups will q...
Why your health insurance problem might not be over when you turn 65
Couples with an age gap have an extra consideration: How to continue coverage for the younger spouse who’s not yet eligible for Medicare.
Health Brief: Exclusive | Inside the new health price transparency rules
Plus: Trump’s checks to Medicare enrollees could complicate year-end health care negotiations,
Digital Science appoints Charlesworth as strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector
Digital Science has appointed Charlesworth as its strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector. This collaboration aims to support the growing demand for research data and information across this rapidly developing market.
Duke Recruiting: Crystal Balls For A Five-Star Target
Are things looking good for Asa Montgomery to Duke?
Can Washington Nationals Bounce Back Into Playoff Team in 2027?
Can the Washington Nationals flip the script to become a playoff contender in 2027?
Building something with your hands — and a career
MakerSpace NYC is one of at least 2,000 community workshops across the country.
New TV shows to watch this week: Tune in to 'Cupertino' on CBS, stream 'Carrie' on Prime Video and revisit 'The Haunting of Hill House' on Netflix
The new TV shows worth watching — from the HBO divorce drama "War" to Netflix's "East of Eden" adaptation and a seaside mystery starring Josh Hartnett.
KUNC's 2026 midterm election voter guide for Northern Colorado
Everything Northern Colorado voters need to know about the state’s midterm election, including major races, ballot measures, voting deadlines, how to return your ballot, and where to find trusted election resources.
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 2
Image 2 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Fresh Kills Park. Image © USEPA Environmental-Protection-Agency - December 6, 2012 via Wikipedia under Public Domain
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 3
Image 3 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Alsergrund, Viena. Image © C.Stadler/Bwag, via Wikipedia under CC BY-SA 4.0
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 4
Image 4 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Agbogbloshie. Image © Muntaka Chasant, via Wikipedia under CC BY-SA 4.0
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 1
Image 1 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Incineration Line in Roskilde / Erick van Egeraat. Image © Tim Van de Velde
Gallery of Unearthing the Ground: Architecture and the Politics of Waste - 5
Image 5 of 15 from gallery of Unearthing the Ground: Architecture and the Politics of Waste. Fresh Kills Park. Image © erial View Courtesy of NYC Department of Parks and Recreation
The AI Advantage Minnesota Has Been Building for Decades
Software companies used to defend themselves in a handful of reliable ways. They built useful features, made their products easy to use and counted on the hassle of switching platforms to keep their customers from leaving. A new company that wanted to compete had to invest months, sometimes even years, of engineering time to catch
Instinct users say its AI agent is pushing unsolicited products
Instinct users say the AI agent sent unsolicited shopping picks, raising questions about whether it's monetizing their data.
What Holding Eye Contact While Someone Speaks Really Reveals About Your Psychology, According to Science
You are mid-conversation with a friend, nodding along, and suddenly you wonder: am I looking at them too much? Or not enough? Most of us treat eye contact like an automatic reflex – something we either do or don’t, without thinking twice. But researchers say the way you hold someone’s gaze while they speak is...
Reclaiming 'Health Sovereignty': EU Gastein Forum Confronts A Fragmenting Global Order
Health, long treated as a sanctuary of diplomatic consensus, has entered an era of high politics and ideological division. Leading the closing panel of the EU Health Forum Gastein (EHFG) on Friday (2 October), session chair Ilona Kickbusch, founder of the Global Health Centre at the Graduate Institute in Geneva, highlighted how recent votes at the UN General Assembly demonstrate that nation-states increasingly split and vote instead of searching for consensus.
'Totally Spies!' Expands Licensing with Apparel and Jewelry Deals
Banijay Kids & Family announces new "Totally Spies!" licensing agreements spanning apparel, jewelry and publishing as the franchise marks 25 years.
THIS WEEK: “Sick of It! Fix Health Care Now” Bus Tour Kicks Off With Stops in Maine, New Hampshire, New York, Pennsylvania, New Jersey
Rep. Maggie Goodlander (D-NH-02), PA Lt. Gov. Austin Davis Will Headline “Sick of It! Fix Health Care Now” Events in Five States Watch All Bus Tour Stops Live Here. Washington,...
Medicare-for-all is back. Now comes the hard part.
Democrats are reviving an old idea. Now they have to define it and pay for it.
Game Preview: Winnipeg Jets @ Pittsburgh Penguins 10/5/2026
Who: Winnipeg Jets (1-0-1, 4th place Central Division) @ Pittsburgh Penguins (2-0-0, 1st place Metropolitan Division) When: 7:30 p.m. eastern How to Watch: Locally televised game on Sportsnet Pittsburgh, Sportsnet+ up in Canada, out-of-market streaming on ESPN+ Pens’ Path Ahead: Up next for the Penguins will be two road games against division opponent, Washington on Wednesday […]
Florida commissioner’s social media on science standards aims for attention
The big story: When Henry Mack III became Florida’s education commissioner in the summer, public education advocates expressed high hopes for the positive way he kicked things off with school official...
Morrell to join Portsmouth's coaching staff
Ex-Portsmouth and Wales midfielder Joe Morrell will be returning to his former club as a coach, joining John Mousinho's backroom staff.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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Jeffries says House Democrats reaching to flip Trump districts in attempt to repeat their 2018 sweep
House Democratic leader Hakeem Jeffries says his party is on track to win back control of the House | WWJ Newsradio 950
Jeffries says House Democrats reaching to flip Trump districts in attempt to repeat their 2018 sweep
House Democratic leader Hakeem Jeffries says his party is on track to win back control of the House.