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Business owner spends nearly five decades ‘multi-tasking’ in Auburn
Connie Dorsch, 79, provides services related to upholstery, quilting, floor coverings, engravings and more. She started this business with her husband in 1977.
‘Ahead of his time’: Donation gives BRAF ownership of Newtron Group
Founder of billion dollar company The Newtron Group prepared for the company to be donated to the Baton Rouge Area Foundation more than a decade prior to his July 2025 death. The donation will ensure that the company maintains its employees, leadership and contributions to charitable causes dear to the founder.
Arts and Entertainment Agenda, April 3 to 10
The Wood Brothers, April 3 The roots folk blues trio The Wood Brothers will perform at 7:30 p.m. April 3 at The Wheeler Opera House, 320 E. Hyman Ave. The Wood Brothers bring decades of...
How can science support and enable the High Seas Treaty?
The Biodiversity Beyond National Jurisdiction (BBNJ) agreement—often known as the High Seas Treaty—came into force in January 2026 following almost two decades of negotiations. Its key objectives are ...
Poll: Congressional redistricting popular among Republicans, underwater with everyone else
Legislators are expected to convene later this month for a rare mid-decade reapportionment.
Marathon review: Bungie’s extraction shooter is a brutal beauty
Marathon, the first non-Destiny game from Bungie in more than a decade, is equal parts frustration and elation, writes our reviewer.
Fossil of Pincer-Wielding Crawler Reveals Origins of Spiders, Scorpions and Others
Researchers argue that a newly examined specimen found decades ago in Utah provides new clues to the ancestors of chelicerates before the group hit it big on land.
Washington doctors are sounding alarm on cannabis health effects, survey shows
More than a decade after recreational cannabis was legalized in Washington, a new survey of health care providers suggests many clinicians are concerned about its effects on patients’ mental health.
Historic Rock Island Bridge opens in Kansas City as new entertainment district over Kansas River.
After almost a decade of planning and work, the Rock Island Bridge opens to the public at 11 a.m. Wednesday, transforming a 1905 railroad bridge into an entertainment district over the Kansas River.
Democrats try new tactic to win a House seat in Utah — running as progressives in a red state
For decades, Democrats' only chance of getting elected to Congress from the conservative state of Utah was by convincing voters that they were sensible moderates. But the political landscape has changed, thanks to a redistricting shakeup that created a deep blue district anchored by Salt Lake City.
Scientists open 40-year-old salmon and find a surprising sign of ocean recovery
Old canned salmon turned out to be a time capsule of ocean health. Researchers found that rising levels of tiny parasitic worms in some salmon species suggest stronger, more complete marine food webs. Because these parasites depend on multiple hosts—including marine mammals—their increase may reflect ecosystem recovery over decades. What looks unappetizing may actually be a sign of a healthier ocean.
Scientists discover hidden “winds” inside cells that could explain cancer spread
Cells aren’t as passive as scientists once thought—they actively create internal currents to move proteins quickly and efficiently. These “cellular winds” push materials to the front of the cell, enabling faster movement and repair. Discovered by chance and confirmed with advanced imaging, this system challenges decades of textbook biology. It may also reveal why some cancer cells spread so rapidly.
Surprising study shows Alzheimer's may start in the body instead of the brain, a discovery that turns medical science upside down
Alzheimer’s disease may begin outside the brain, with inflammation in organs like the skin, lungs, and gut decades before symptoms appear.
New memory chip survives temperatures hotter than lava
The electronics inside your phone, your car, and every satellite currently orbiting Earth share one critical weakness: heat. Push them past about 200 degrees Celsius and they start to fail. For decades, ...
Who Gets to Do Science?
Who Gets to Do Science?: A neuroscientist who spent the last decade tearing down the class, race, and language barriers that keep people like him out of research
Back to Business Program helps Quynh’s Pharmacy continue serving Little Saigon community
Quynh’s Pharmacy is a fixture in Little Saigon. The owner, Mary Bui, is also a fixture within the pharmacy, having worked there for three decades. When vandals broke the glass entry door and both security gates, Bui faced a steep bill to repair the damages. “They charged over $6,000,” she explained. “We had to do […]
Munson’s Chocolates Selected for TD Small Business Takeover at TD Garden During March 31st Bruins Game
Eight Decades of Handcrafted Chocolate Meets One of Boston’s Biggest Stages
JPMorgan's Jamie Dimon plans small business lending, hiring push to shore up American Dream
JPMorgan Chase said on Tuesday it plans to lend $80 billion to US small businesses over the next decade and add 1,000 bankers as part of a multiyear push to go after more Main Street customers.
Texas Health Resources CEO retiring after four decades
The hospital system will see a new CEO later this year, with an internal leader slated to take over.
Is longevity science stuck? Researchers call for a strategic reset
After decades of progress, longevity science may be facing a paradox: more knowledge, but limited impact. Some researchers now suggest the field may have failed not because of insufficient data, but because of flawed strategy.
Swope telescope: five decades of observing and reinvention
Astronomer Nidia Morrell looks back on more than 20 years of observing at the Las Campanas Observatory—an era marked by the transition from manual methods to digital systems—and reflects on the enduring relevance of a telescope that remains central to modern astronomy.
Delaware YouTube star talks buying a 'house' and being 'class clown'
New Castle County native Chris Klemens didn’t invent the man on the street style of interviewing, but he's been doing it for well over a decade.
SB26-140 will protect access to rare disease treatments
By Amanda Boone There are moments in life that leave an indelible mark on your soul. For me, one came in the middle of the night when I took a full breath for the first time in over a decade. At first, I was confused — then I realized what it was. I woke my […]
The brutal politics of property tax reform
Alongside his plan to freeze rents on a million apartments, Mamdani said he would reform a lopsided property tax system that for decades has left rental landlords facing disproportionate financial pain.
There may be 10 times as many citizen scientists in Australia as we thought – and that’s great news for science
Citizens have contributed to science in Australia for many decades – and the field is now undergoing rapid growth
Mark Sanford, Years After Scandal, Aims for a Comeback to Congress
The former South Carolina governor and congressman filed papers to run for his old seat, six years after running for president and nearly two decades after a high-profile affair.
A decade of impact in maternal and child health
As we celebrate 10 years of giving, we are proud of what donors and partners have achieved to decrease maternal and infant deaths.
Some are celebrating, but World of Warcraft's move away from the "Horde" and "Alliance" faction split will be seen as a historic mistake
Not only does it undermine decades of lore and world building, but player identity is how you reach your audience when they're *not* gaming. WoW's iconic faction split is under threat, and that's a bad thing actually.
Survey: More than half of Washington clinicians cite mental-health risks from cannabis use
More than a decade after Washington legalized recreational cannabis, a new survey suggests many clinicians are increasingly worried about the mental-health risk
What do you want to know about beta-blockers?
For decades, beta-blockers have been commonly prescribed as a standard treatment for adults who have had heart attacks with no complications and many people continue the medications for life. But a growing body of research has begun to question that approach.
In wrangling dark matter, some scientists find inspiration in the Torah, Krishna and Christ
Dark matter and dark energy are mysteries that have confounded scientists for decades, even though they comprise 95% of the universe's mass.
Op-Ed | Fueling NYC’s $50 billion engine: How women business owners can grow and scale
Over the last decade, the number of women-owned firms in NYC has grown by 43%, becoming a powerful force in the city’s economic momentum. Over the past
‘And then we saw the little head.’ Scientists witness rare sperm whale birth
Few people have been lucky enough to see a whale birth, with the last one witnessed decades ago. Now, two major papers describe a 2023 birth captured by researchers.
Science, Music, and Stream Bugs: Sierra Streams Celebrates 30 Years at Pioneer Park on May 16
NEVADA CITY, CA — Sierra Streams Institute will celebrate its 30th anniversary with a free community event on Saturday, May 16 from 1:00 to 5:00 PM at Pioneer Park in Nevada City, bringing together art, music, and hands-on science to highlight three decades of watershed research, restoration, and education across the Sierra Nevada. The Sierra […]
After a heart attack, beta-blockers are often a lifelong medicine. Maybe they shouldn’t be
For decades, surviving a heart attack has come with a lifelong prescription: Stay on medications called beta-blockers to help protect your heart. But doctors are taking a closer look at whether long-term beta-blocker use is really necessary, especially beyond the first year of recovery.
Lomo Meats: A local shop built on science and family roots
Samuel Garcia spent more than a decade building his expertise in meat science, working and teaching at the University of Arizona.
Pitt commits $5M in new investments to city parks, neighborhood business corridors and public safety
The University’s most recent commitment builds on decades of collaboration and support between the City of Pittsburgh and its premier anchor institution.
Xi Invites Taiwan’s Opposition Leader to First Visit in Decade
China has invited the leader of Taiwan’s opposition party to visit the mainland next month, the first such trip by a sitting leader of the Kuomintang since 2016.
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Scientists Solve Decades-Long Mystery About Why Saturn Appears To Change Its Spin
Researchers at Northumbria University have used the most powerful space telescope ever built to answer one of the longest-standing puzzles in planetary science – why does Saturn appear to spin at a...
Swalwell accuses Trump of trying to influence California governor's race with old FBI files
California gubernatorial candidate Rep. Eric Swalwell says FBI Director Kash Patel's push to release decade-old case files is a Trump hit job.
In wrangling dark matter, some scientists find inspiration in the Torah, Krishna and Christ
Dark matter and dark energy are mysteries that have confounded scientists for decades, even though they comprise 95% of the universe's mass.
Psychology says people who prefer texting to phone calls aren't being antisocial - they're protecting the quality of their thinking from the demands of real-time performance
At some point in the last decade, preferring to text became something people apologize for.
Kash Patel’s push against Democratic lawmaker raises concerns within FBI
FBI Director Kash Patel is pressing to release a decade-old investigative file involving Rep. Eric Swalwell (D-California) and a suspected Chinese intelligence operative.
Scientists say the evidence is clear: E-cigarettes beat patches and gum in helping smokers quit
Nicotine e-cigarettes may be one of the most effective tools yet for quitting smoking, according to a sweeping review of global research. By analyzing findings from 14 major reviews spanning nearly a decade, researchers found consistent, high-quality evidence showing that nicotine vapes outperform traditional methods like patches, gum, and even behavioral support. While some lower-quality studies produced mixed results, the strongest data clearly favored nicotine e-cigarettes.
New cholesterol guidelines could change when you get tested
A major new U.S. cholesterol guideline is shifting the focus toward earlier, more personalized prevention of heart disease. It urges people to start screening sooner—sometimes even in childhood—and highlights the importance of tracking not just LDL (“bad”) cholesterol but also genetic risk factors like lipoprotein(a). A new, more advanced risk calculator now uses broader health data to better predict heart attack and stroke risk over decades.
What it means to be a woman in business
I am currently a Senior Key Account Manager at Alliant Energy. In my role, I’m responsible for managing some of our major commercial and industrial customers, and I also get the opportunity to support economic development across the communities we serve. This year marks nearly a decade for me at Alliant Energy — a journey […]
Vance or Rubio? CPAC debates a Republican Party after Trump
A decade ago, Jessica Luebbers could not have imagined supporting Marco Rubio for president. His acrimonious race to stop Donald Trump’s march to the White House in 2016 left a bitter taste in her mouth.
Indian Health Service is digging out of decades-old construction backlog for medical buildings
A recent $1B pledge from HHS Secretary Robert F. Kennedy Jr. could help the agency chip away at a construction backlog
I always wanted to live in Europe, bought tiny home: why I'm leaving
A therapist from New York wanted to live in Europe for decades. At age 51, she moved into a Dutch tiny home, and learned the style of living suited her, but not the Netherlands.
The top moments from this year's CPAC conference in Texas
President Donald Trump did not attend one of the biggest yearly meetings of conservatives for the first time in nearly a decade
Larry Price, former UH football coach and longtime broadcaster, dies
Larry Price, a one-of-a-kind homegrown talent who helped shape University of Hawaii football and local sports media for decades, has died.
Takeaways from Day 2 of CPAC 2026
The Conservative Political Action Conference’s annual gathering in Texas — like most of its meetings over the last decade — was largely a pro-President Donald Trump pep rally. But several moments over the first two days of the event made clear that there are also rifts on the right that couldn’t be smoothed over among the activists gathered just outside Dallas.
Playing Wolfenstein 3D with one hand in 2026
Over three decades later, this historical curiosity has more than a few rough edges...
Apple hires ex-Google executive to head AI marketing amid push to improve Siri
SAN FRANCISCO, March 27 (Reuters) - Apple on Friday said it has hired Lilian Rincon, who previously spent nearly a decade at Google overseeing its shopping and assistant products, as the vice
Apple hires ex-Google executive to head AI marketing amid push to improve Siri
Apple on Friday said it has hired Lilian Rincon, who previously spent nearly a decade at Google overseeing its shopping and assistant products, as the vice president of product marketing for artificial intelligence, reporting to its marketing chief Greg “Joz” Joswiak.
Apple hires ex-Google executive to head AI marketing amid push to improve Siri
SAN FRANCISCO, March 27 (Reuters) - Apple on Friday said it has hired Lilian Rincon, who previously spent nearly a decade at Google overseeing its shopping and assistant products, as the vice
Student discovers new Galápagos bird, solving a decades-old mystery
As far as herons go, this colorful bird is rather petite.
Mac Pro Discontinued: Reflecting on 20 Years of Apple's Desktop Tower
Apple this week announced that it has discontinued the Mac Pro, with new configurations no longer available and no further models planned. Below, we reflect on nearly two decades of the Mac Pro. 2006 to 2013 In August 2006, Apple introduced the original Mac Pro, which was an Intel-based follow-up to the PowerPC-based Power Mac G5 that debuted a few years earlier. Mac Pro was the final Mac model to transition from PowerPC to Intel processors.
The Future of Trans Athletes in Sports
More than half of U.S. states have banned trans athletes from school sports. A trans athlete and activist who has been at the leading edge of policy change for over a decade says these bans have far-reaching implications.
NC prison health care costs soar as population ages
Spending has jumped 65 percent in a decade, driven by an aging population, staff shortages and increased reliance on community providers.
‘A bad day’: Providence police navigate a record level of mental health calls
There has been a 238 percent increase in mental health incident calls to Providence police in the last decade.
More concussions equal worse brain health 5 years after college sports
New concussion study deviates from the norm; most research in this space examines people in their 50s or 60s — decades after sport participation. Instead, this U-M study looks at college athletes in their 20s, and researchers already see the impact of concussion, which enables early intervention.
Exclusive: Occidental's Hollub, US oil's most powerful woman, prepares to hand over reins, sources say
Vicki Hollub is preparing to retire as chief executive of Occidental Petroleum , after her decade-long stewardship of the U.S. oil and gas company that made her one of the most powerful women in a male-dominated industry, sources familiar with the matter told Reuters.
Iran war's environmental toll could leave damage and health risks for decades, experts say
The Iran war is unleashing a toxic mix of chemicals, heavy metals and other pollutants that threaten everything from agriculture to drinking water to people’s health.
Iran war's environmental toll could leave damage and health risks for decades, experts say
The Iran war is unleashing a toxic mix of chemicals, heavy metals and other pollutants that threaten everything from agriculture to drinking water to people’s health.
New Ford Mustang EcoBoost TLD Signature Edition Has Amazing Retro Graphics, And Only 550 Will Be Made
The graphics were created by Troy Lee Designs, who has been painting helmets for race car drivers for decades.
Indian Health Service is digging out of decades-old construction backlog for medical buildings
The U.S. agency that provides healthcare to Native Americans has a facilities problem.
Indian Health Service chips away at construction backlog
The U.S. agency that provides healthcare to Native Americans has a facilities problem. Buildings in its inventory are decades-old, dilapidated and don't have enough space to care for a growing population.
Distinguished Binghamton Professor and Nobel laureate elected AAAS Fellow
Distinguished Professor of Chemistry M. Stanley Whittingham elected for his decades of lithium-ion battery research
Fresno State changes its sports marketing model after decades
Fresno State Athletics announced the launch of Bulldog Sports Enterprises, a locally based multimedia rights and corporate agency, marking a major change in how the program approaches revenue generation and business operations, the athletic department
Critically endangered hare spotted in surprising location for the first time in 40 years — but it was already dead
Scientists in China have announced the first confirmed sighting of the critically endangered Hainan hare in part of its native range in four decades, after spotting its completely flattened carcass on a roadside.
Shop the 34 best deals on earbuds, chargers and smart lights for spring Prime Day
Amazon’s Big Spring Sale is officially live. I used my decade of experience covering deals and the latest electronics to find my favorite tech discounts.
RPI Athletics Celebrates 50 Years of Women's Sports
Rensselaer Polytechnic Institute proudly celebrates 50 years of women's varsity athletics—a milestone that reflects decades of progress, achievement, and opportunity for generations of student-athletes. What began as a commitment to expanding access in intercollegiate athletics has grown into a vibrant and competitive tradition that continues to shape the RPI community today.
Scion of historic Fargo business dies at 98
Robert B. Herbst, who ran Fargo's Herbst department store for decades, is being remembered for his humor, passion for the outdoors, and devotion to family.
Amex Makes Its Biggest Commercial Bet in Years With ‘Business Membership’
Watch more: Need to Know With American Express’ Raymond Joabar The corporate card has been a remarkably stable product for decades. It processes, tracks
How this Indiana teacher makes her AP personal finance class click for students
With over two decades of teaching under her belt, Kristin Lidstrom is piloting the AP class for Fishers students. “By the time students are making real financial decisions, they should already feel confident navigating them, not encountering the concepts for the first time,” she said.
The labor leader behind California’s billionaire tax showdown
For decades, Dave Regan has used California’s direct democracy system in a relentless campaign to shore up union power — and his own. But his newest mission is on an entirely different scale.
Jay-Z felt 'uncontrollable anger' amid sexual assault, rape lawsuit
Jay-Z has broken his silence about the lawsuit that accused him and fellow music mogul Sean "Diddy" Combs of raping a teenage girl more than two decades ago.
Missouri court upholds mid-decade congressional redistricting backed by Trump
A Missouri court has upheld a mid-decade redistricting plan that gives Republicans a chance to win an additional congressional seat in this year’s midterm elections
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Supercomputers just solved a 50-year-old mystery about giant stars
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Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds
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There’s little information about a large measles outbreak in Florida, so we went to see it
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Scientists twisted a mysterious superconductor and got a shocking result
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Apple TV Is Now Almost 20 Years Old
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For decades, no one listened to him… today his theory about the origin of life is intriguing scientists - Futura-Sciences
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Amazon developing new AI-driven smartphone years after Fire Phone flop: report
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Amazon developing new AI-driven smartphone years after Fire Phone flop: report
Amazon is reportedly developing an AI smartphone codenamed "Transformer" with Alexa integration over a decade after its failed Fire Phone launch.
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