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Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” premiered over the weekend as the centerpiece of the New York Film Festival. Gilroy’s first film since the Star Wars series “Andor” concluded its acclaimed two-season run,

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Oct 5 • 4:34 PM EDT • Politics • oskaloosa.com
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” | WWL

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Oct 5 • 4:34 PM EDT • Entertainment • audacy.com
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'

Tony Gilroy’s “Behemoth!” | KYW Newsradio

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Oct 5 • 4:34 PM EDT • Politics • audacy.com
Tony Gilroy on Leaving the Politics of 'Andor' Behind for His 9-Composer Music Drama 'Behemoth!'

NEW YORK (AP) — Long before Tony Gilroy wrote “The Bourne Identity," made “Michael Clayton” or created “Andor,” he wanted to be a musician. After playing guitar in a string of bands, Gilroy came to Los Angeles hoping to become a studio musician. A session with some real players quickly disabused him ...

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Oct 5 • 4:34 PM EDT • Politics • usnews.com
Third-quarter results are scheduled after market close Oct. 29; First Business Bank takes questions next morning.

Q3 results will be released after market close Oct. 29. The Oct. 30 call starts at 8 a.m. Central, with a simultaneous webcast and investor questions.

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Oct 5 • 4:30 PM EDT • Business • stocktitan.net
Fox Creator Studios Hires Senior Executives

Bryan Thoensen and Kirsten McAuliffe join the media company as it seeks to push further into the creator economy.

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Oct 5 • 4:28 PM EDT • Business • hollywoodreporter.com
CMS student among top 30 finalists nationwide in science competition

Isabella Garry is being honored for a project exploring whether natural materials can remove microplastics from simulated stomach fluid.

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Oct 5 • 4:22 PM EDT • Science • eplocalnews.org
Budding food scrap businesses want your coffee grounds and eggshells

Composting leftover coffee grounds, eggshells and carrot tops is a way to reduce the amount of food waste that goes into landfills, where it produces the potent greenhouse gas methane

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Oct 5 • 4:16 PM EDT • Business • latimes.com
NYC Health + Hospitals/Queens Hosts Community Health Fair as Centerpiece of Hispanic Heritage Month Celebrations

NYC Health + Hospitals/Queens hosted a comprehensive Community Health Fair on September 30, serving as the primary event in the hospital’s month-long

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Oct 5 • 4:15 PM EDT • Health • nychealthandhospitals.org
Trump’s midterm messaging undercuts GOP candidates

Many Republican candidates have found themselves in surprisingly competitive races

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Oct 5 • 4:15 PM EDT • Politics • spectrumlocalnews.com
Trump’s midterm messaging undercuts GOP candidates

Many Republican candidates have found themselves in surprisingly competitive races

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Oct 5 • 4:15 PM EDT • Politics • spectrumlocalnews.com
Maloy and Udell clash on Utah's public lands in 3rd District debate

Republican Celeste Maloy and Democrat Kent Udell also offered competing approaches to energy, water, and wildfire management.

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Oct 5 • 4:07 PM EDT • Politics • upr.org
Is This A Healthcare Economy?

This analysis examines recent jobs growth in health care and how it compares to the rest of the economy. Health care employment has grown faster than other sectors of the economy, with jobs in physician offices, hospitals, outpatient care centers, home health, and other settings increasing over the past year even as the rest of the job market plateaued.

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Oct 5 • 3:44 PM EDT • Health • kff.org
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.

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Oct 5 • 3:42 PM EDT • Entertainment • entertainment.substack.com
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Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027

The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.

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Oct 5 • 3:26 PM EDT • Business • bizfayetteville.com
Poor leaders can tank employees’ mental health (and the company); his business summit puts workplace culture

“I’m a big believer in human to human connection because there’s so much loneliness and isolation happening,” explained Ebrima “Abraham” Sisay, host of the You Gotta No! Podcast (YGN) and its annual YGN Summit. “That’s because we’re getting further away from what we are meant to do as humans.”

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Oct 5 • 3:22 PM EDT • Business • startlandnews.com
Edison's Entertainment Complex Female Athlete Of Month: Jess Sever Has Made Important Contributions To Edwardsville Girls Flag Football Team

Edwardsville sophomore Jess Sever has five touchdowns as the undefeated Tigers girls flag football team advances in the IHSA postseason.

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Oct 5 • 3:20 PM EDT • Entertainment • riverbender.com
Supreme Court weighs local governments' climate lawsuits against oil, gas firms

Key justices appeared wary about the potential sweep of litigation, but torn over the complex legal interplay of federal and state laws raised by the case

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Oct 5 • 2:42 PM EDT • Politics • spectrumlocalnews.com
Supreme Court weighs local governments' climate lawsuits against oil, gas firms

Key justices appeared wary about the potential sweep of litigation, but torn over the complex legal interplay of federal and state laws raised by the case

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Oct 5 • 2:42 PM EDT • Politics • spectrumlocalnews.com
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180-employee Manatee HVAC, plumbing company names new CEO

Arctic Air Home Services makes a leadership change as it aims toward growth in the region.

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Oct 5 • 2:22 PM EDT • Business • businessobserverfl.com
Newcastle gets $25M refinancing for West Loop apartments

Refinancing can be a challenge in today’s elevated interest rate environment, but Northmarq said the process was competitive because of strong lender appetite for apartment buildings.

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Oct 5 • 2:20 PM EDT • Business • chicagobusiness.com
Floating Leaf Entertainment Joins Red Light Management

Austin-based artist management company Floating Leaf Entertainment, founded by Jeb Hurt [...]

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Oct 5 • 2:19 PM EDT • Entertainment • musicrow.com
Jumbo $5.8B freight brokerage deal will ripple through Chicago

C.H. Robinson is buying RXO, the parent company of Coyote Logistics.

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Oct 5 • 2:16 PM EDT • Business • chicagobusiness.com
How a controversial camera system is monitoring mental health patients

The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment

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Oct 5 • 2:03 PM EDT • Health • channel4news.substack.com
Massachusetts Governor Urges No Vote on Cannabis Prohibition Measure

Gov. Maura Healey said she opposes Question 8, a ballot measure that aims to wipe out the state’s adult-use legalization laws.

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Oct 5 • 2:01 PM EDT • Business • cannabisbusinesstimes.com
At 19, Ghost founder raises $11 million to build a $3,499 computer for your personal AI

Ghost announced Monday its official emergence from stealth and an $11 billion seed round led by Andreessen Horowitz.

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Oct 5 • 2:00 PM EDT • Technology • techcrunch.com
Google's Mysterious New Fitbit Just Got a Lot More Real

The Fitbit Edge has a screen and a similar collection of sensors to the company's recent screenless wearable, according to new leaks.

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Oct 5 • 1:50 PM EDT • Technology • gizmodo.com
Rural and Urban Health Center Patients and Financing

This brief reports on rural and urban health center patients and financing in 2025 using national data from the Uniform Data System (UDS) and examines potential impacts of recent federal policy changes.

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Oct 5 • 1:47 PM EDT • Health • kff.org
Saquon Barkley injury update is encouraging news for Eagles

The Philadelphia Eagles may not be forced to compete without their star running back for long.

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Oct 5 • 1:42 PM EDT • Sports • sports.yahoo.com
Planet Fitness acquires Bakersfield’s Body Xchange Health Club locations

Body Xchange Health Clubs announced that they have been acquired by Planet Fitness.The announcement was posted on their social media pages.The company said that

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Oct 5 • 1:40 PM EDT • Health • bakersfieldnow.com
Mundelein resident chosen as finalist in Advocate Health Has Talent competition

Mundelein resident Gerardo Ocampo was driving his wife and child home from the airport when he received a call from his supervisor at Advocate Condell Medical Center.

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Oct 5 • 1:35 PM EDT • Health • chicagotribune.com
Amy Coney Barrett calls oil companies’ arguments ‘slippery’

Supreme Court Justice Amy Coney Barrett criticized fossil fuel companies as “a little slippery” in oral arguments over a lawsuit in which oil majors claim that federal law blocks states from suing them for climate change-related damages. Her comment came in arguments Monday in the case Suncor Energy v. County Commissioners of Boulder County, which […]

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Oct 5 • 1:35 PM EDT • Politics • coloradopolitics.com
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Banijay Entertainment Consolidates U.S. Operations to 'Banijay America' Under CEO Ben Samek

Banijay Entertainment Oct. 5 announced it is consolidating its U.S. operations under a new moniker, Banijay America, under the direction of CEO Ben Samek, who reports to Jane Turton, deputy CEO of Banijay Entertainment. The company is restructuring its operational footprint to centralize leadership and operational support while keeping its individual production labels creatively independent. … Continue reading "Banijay Entertainment Consolidates U.S. Operations to ‘Banijay America’ Under CEO Ben Samek"

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Oct 5 • 1:33 PM EDT • Entertainment • mediaplaynews.com
Why Sphere Entertainment (SPHR) Stock Is Trading Lower Today

What Happened? Shares of content production and distribution company Sphere Entertainment (NYSE:SPHR) fell 12.3% in the afternoon session after Craig-Hallum ...

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Oct 5 • 1:25 PM EDT • Entertainment • stockstory.org
TNT Sports head Luis Silberwasser to depart Skydance as CBS Sports chief David Berson takes over combined global sports group

TNT Sports chief Luis Silberwasser will be leaving a combined Paramount Skydance-Warner Bros. Discovery company, sources tell CNBC.

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Oct 5 • 1:04 PM EDT • Sports • cnbc.com
Best Entertainment Stocks To Watch Now

Warner Bros. Discovery, Autodesk, DraftKings, Verizon Communications, and Spotify Technology are the five Entertainment stocks to watch today, according to MarketBeat's stock screener tool. Entertainment stocks are shares of publicly traded companies involved in producing, distributing, or deliveri

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Oct 5 • 1:02 PM EDT • Entertainment • marketbeat.com
NWA C-Suite: Sam Sicard

Since taking the helm at the age of 35, Sicard has grown assets from $1.5 billion to $3.5 billion. He has also expanded the company’s footprint into eastern and southwestern...

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Oct 5 • 1:00 PM EDT • Business • talkbusiness.net
Darling completes sale of sausage casings business to SARIA

Sale positions company for continued growth and value creation potential while optimizing portfolio and reducing debt.

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Oct 5 • 12:43 PM EDT • Business • feedstuffs.com
Banijay America Confirms Ben Samek as CEO, Post-Merger With All3Media

Banijay America has confirmed its new structure post-merger with All3Media, as Ben Samek will serve as CEO of the combined company.

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Oct 5 • 12:40 PM EDT • Entertainment • variety.com
Computer science student is a CEO before earning diploma

Marcel Slowikowski (’26 computer science) launched an AI startup this summer, months before he earns his computer science degree.

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Oct 5 • 12:18 PM EDT • Science • news.las.iastate.edu
RSU and USAO partner to create Accelerated Master's Program for computer science students

Rogers State University (RSU) and the University of Science & Arts of Oklahoma (USAO) have partnered together to create an Accelerated Master's Program for comp

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Oct 5 • 12:18 PM EDT • Science • ktul.com
RSU and USAO partner to create Accelerated Master's Program for computer science students

Rogers State University (RSU) and the University of Science & Arts of Oklahoma (USAO) have partnered together to create an Accelerated Master's Program for comp

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Oct 5 • 12:17 PM EDT • Science • fox23.com
Googlebooks with Intel chipsets might have trouble with ‘complex’ Android apps

According to a statement from Google, Intel-based Googlebooks will apparently still struggle with some Android apps. When Android apps made...

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Oct 5 • 12:15 PM EDT • Technology • 9to5google.com
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree

Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape. Mr. Manigan and the other honorees will be recognized by NJBIZ at an awards ceremony taking place today.

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Oct 5 • 12:10 PM EDT • Health • rwjbh.org
Unfinished Business: Dean Rajan Appointed to Historic Third Term

Madhav Rajan reflects on nine years of leading Chicago Booth and what he wants to accomplish in the years ahead.

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Oct 5 • 12:02 PM EDT • Business • chicagobooth.edu
Mary McNamara: As David Ellison names his new empire Skydance, the message is clear: He owns Hollywood

LOS ANGELES — What a surprise. David Ellison has decided to name the Frankenstudio media company created by the merger of Paramount Skydance and Warner Bros. Discovery simply Skydance. And

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Oct 5 • 11:45 AM EDT • Entertainment • thederrick.com
No stadium has a story like the Superdome

The Superdome has weathered the highest of highs and the lowest of lows to represent the complicated and celebrated history of its city.

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Oct 5 • 11:39 AM EDT • Sports • sports.yahoo.com
Politics on Stage. Wonderful Life on Broadway. Jeremy O Harris to Mamdani: Call me. Stageworthy News of the Week.

On stage during the first week of October: Plays about the Epstein Files. Gun violence. Black women silenced. Complicity. Sexism. Homophobia. This seems an unusual burst of political theater even f…

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Oct 5 • 11:34 AM EDT • Politics • newyorktheater.me
New Regulations Make It Easier to Find, Compare, and Report Healthcare Pricing and Coverage Information

HHS announced that Americans will have access to more reliable, accessible, and actionable information about their health coverage

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Oct 5 • 11:30 AM EDT • Health • hhs.gov
Small Businesses Skip the Cross-Border Plumbing Big Companies Can’t Escape

Conventional wisdom says large corporations should dominate cross-border payments. They have global banks, treasury teams, negotiated FX rates,

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Oct 5 • 11:26 AM EDT • Business • pymnts.com
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Silly Dillys Wins $30,000 at RISE Up Harlingen Business Pitch Competition

Silly Dillys captured first place and a $30,000 award at the third annual RISE Up Harlingen Business Pitch Competition, leading a group of local entrepreneurs receiving financial support to develop and expand their businesses.

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Oct 5 • 11:15 AM EDT • Business • texasborderbusiness.com
Claims that genAI speeds up PC ports of classic games are either "false" or missing the point, says Banjo Kazooie: Recompiled developer

A Banjo Kazooie: Recompiled developer has spoken out against the idea that generative AI allows for faster PC ports and, therefore, better preservation.

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Oct 5 • 11:13 AM EDT • Technology • rockpapershotgun.com
FSU data scientist receives NSF CAREER Award to develop AI model to analyze complex numerical data at scale

A Florida State University artificial intelligence and data scientist has earned one of the most prestigious early career faculty awards to develop a new

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Oct 5 • 11:12 AM EDT • Science • news.fsu.edu
OPINION: Pay for performance, not for politics

The North Carolina General Assembly approved substantial pay increases for public schoolteachers earlier this year. If a bipartisan commission has its way, teacher compensation will soar over …

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Oct 5 • 11:04 AM EDT • Politics • richmondobserver.com
Traders Purchase Large Volume of Call Options on Sphere Entertainment (NYSE:SPHR)

Sphere Entertainment Co. (NYSE:SPHR - Get Free Report) saw unusually large options trading activity on Monday. Traders bought 9,775 call options on the company. This represents an increase of 1,615% compared to the typical volume of 570 call options.

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Oct 5 • 11:00 AM EDT • Entertainment • marketbeat.com
CT Business Blend: Oct. 5, 2026

Hartford Business Journal’s Greg Bordonaro and WTIC’s Brian Shactman explore the people, companies and trends shaping Connecticut’s business scene every Monday at 8:30 a.m. on WTIC 1080 AM.

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Oct 5 • 10:55 AM EDT • Business • hartfordbusiness.com
58,000 Hoosiers not in compliance with new HIP work rules

The Indiana Family and Social Services Administration shared internal estimates Monday showing 58,000 Hoosiers insured through the Healthy Indiana Plan are not in compliance with federal work requirements set to take effect next year.

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Oct 5 • 10:54 AM EDT • Health • indianacapitalchronicle.com
Businesses Finding It Harder to Predict AI Spending

Companies are reportedly finding it increasingly difficult to forecast their AI spending. That’s according to a report Monday (Oct. 5) by The Wall Street

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Oct 5 • 10:47 AM EDT • Business • pymnts.com
RWJBarnabas Health President and CEO Mark E. Manigan Named 2026 NJBIZ Executive Excellence Honoree

Mark E. Manigan, President and Chief Executive Officer of RWJBarnabas Health, the largest, most comprehensive academic health system in New Jersey, has been named a 2026 Executive Excellence honoree by NJBIZ, recognizing his leadership and impact on New Jersey’s health care landscape.

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Oct 5 • 10:45 AM EDT • Health • newswise.com
Zelda and Banjo Recompiled Devs Go To War With AI Vibe-Coded 'Slopcomps'

AI-assisted projects provoking stark criticism

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Oct 5 • 10:22 AM EDT • Technology • kotaku.com
Davids Fights Washington Healthcare Cuts with Plan to Lower Costs, Protect Kansas Hospitals

WASHINGTON, D.C. — Today, U.S. Representative Sharice Davids (KS-03) introduced a comprehensive package of healthcare legislation that directly counters Washington’s recent healthcare rollbacks, which are increasing monthly costs and closing rural hospitals. Davids’ efforts would protect Kansas families from rising medical costs, block new federal red tape, and keep local hospitals and health clinics open.

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Oct 5 • 10:14 AM EDT • Health • davids.house.gov
Governor Ivey Proclaims Alabama Girls in Sports Day -

MONTGOMERY – Governor Kay Ivey on Monday proclaimed Saturday, October 10, 2026, as Alabama Girls in Sports Day, recognizing the female athletes throughout the state and reaffirming Alabama’s commitment to ensuring women and girls have the right to participate, compete … Continued

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Oct 5 • 10:05 AM EDT • Sports • governor.alabama.gov
Nobody remembers your EBITDA at your funeral

David Mammano highlights the importance of balancing profit with purpose in business to build companies that employees, customers, and communities value.

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Oct 5 • 10:00 AM EDT • Business • rbj.net
Science Corp. Announces Long-Term (36 Months) Results of PRIMA BCI Clinical Trial Showing Durable Vision Restoration in Blind Patients Suffering from Geographic Atrophy

Science Corporation, the neural engineering and brain-computer interface (BCI) company, today announced long-term (36 months) followup data from its pivotal ...

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Oct 5 • 10:00 AM EDT • Science • businesswire.com
2026-27 MLS NEXT schedule: Key dates to know

By MLSsoccer staffThe 2026-27 MLS NEXT season will be the seventh and largest in league history, expanding national competition and player development opportunities across North America's top youth so...

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Oct 5 • 10:00 AM EDT • Sports • sports.yahoo.com
Chevron elevates CFO to head oil and gas operations

HOUSTON, Oct 5 (Reuters) - Chevron Chief Financial Officer Eimear Bonner will become president of the US oil producer's oil, products and gas business, the company said on Monday.

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Oct 5 • 9:59 AM EDT • Business • kansascity.com
Scientists Created a Computer Inside a Water Drop Using Billions of DNA Molecules and It Worked

You won’t believe it, but DNA molecules can turn even a tiny drop of water into a computer.

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Oct 5 • 9:52 AM EDT • Science • zmescience.com
Naples Comprehensive Health Names Danny Hogan Chief Financial Officer

October 5, 2026 – Naples Comprehensive Health (NCH) announced today that Danny Hogan has been named its next Chief Financial Officer. Hogan joined the organization on Oct. 5. Hogan brings extensive health care finance and operational leadership experience to NCH. He currently serves as Chief Financial Officer, Shared Services and Integrated Operations, at Bon Secours […]

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Oct 5 • 9:47 AM EDT • Health • southfloridahospitalnews.com
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2026 Outstanding Women in Business

The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.

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Oct 5 • 9:24 AM EDT • Business • wbjournal.com
Apple's Newest Macs Just Got Their Biggest Price Cuts Yet on Amazon

Prime Big Deal Days sales are already starting, and have now hit Apple's brand new Mac mini and Mac Studio computers. You can get up to $199 off these 2026 devices with Amazon's latest savings. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

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Oct 5 • 9:23 AM EDT • Technology • macrumors.com
Neighborhood Intelligence Provides Business Update and Announces $45.5 Million Equity Financing with Participation from Management and a Single Institutional Investor

NASHVILLE, Tenn., October 05, 2026--Neighborhood Intelligence (NASDAQ: NXH) ("Neighborhood" or the "Company") today announced that it has entered into a definitive agreement for the purchase and sale of an aggregate of 16,485,508 shares of its common stock (or pre-funded warrants in lieu thereof) at a purchase price of $2.76 per share (or pre-funded warrant in lieu thereof) in a registered direct offering. In addition, the Company will issue warrants to purchase up to 16,123,189 shares of common

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Oct 5 • 9:07 AM EDT • Business • finance.yahoo.com
Sphere Entertainment (NYSE:SPHR) Downgraded by Craig Hallum to "Hold"

Craig Hallum lowered Sphere Entertainment from a "buy" rating to a "hold" rating and set a $132.00 price objective for the company. in a research report on Monday.

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Oct 5 • 9:06 AM EDT • Entertainment • marketbeat.com
Labour standards increasingly shape market access and business competitiveness

A new ILO Brief examines how labour standards and responsible business expectations are increasingly shaping market access, supply chains and business competitiveness in Asia and the Pacific. It highlights the role of employer and business membership organizations in helping companies navigate evolving requirements and promote better labour outcomes.

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Oct 5 • 9:05 AM EDT • Business • ilo.org
Dhar Mann says YouTubers aren't his rivals. Hollywood is.

BURBANK, CALIFORNIA − Dhar Mann doesn't consider other digital content creators his competition.

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Oct 5 • 9:00 AM EDT • Entertainment • centraloregondaily.com
Is CBIZ (CBZ) Outperforming Other Business Services Stocks This Year?

Here is how CBIZ (CBZ) and GigaCloud Technology Inc. (GCT) have performed compared to their sector so far this year.

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Oct 5 • 9:00 AM EDT • Business • finance.yahoo.com
Star Wars Zero Company Has Received Its First Big Discount at Amazon Before Its October Prime Day Sale Begins, Dropping Below $50

Star Wars Zero Company has dropped to a new low price at Amazon ahead of the retailer's Prime Big Deal Days sale event, with a 20% discount across PS5 and Xbox Series X.

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Oct 5 • 8:59 AM EDT • Technology • ign.com
Health Brief: Exclusive | Inside the new health price transparency rules

Plus: Trump’s checks to Medicare enrollees could complicate year-end health care negotiations,

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Oct 5 • 8:45 AM EDT • Health • washingtonpost.com
Google Admits Some 'Complex' Android Apps Run Poorly On Intel Googlebooks

Android app compatibility on Googlebooks may not be as smooth as previously stated.

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Oct 5 • 8:38 AM EDT • Technology • engadget.com
Asia-Pacific survey to employers and business membership organizations on labour, trade and responsible business conduct

This ILO Brief presents the results of a survey of employer and business membership organizations (EBMOs) in Asia and the Pacific highlights growing business demand for support in navigating labour, trade and responsible business requirements. The findings point to the need for stronger technical expertise, practical tools and sustained support to help businesses maintain competitiveness and meet evolving market expectations.

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Oct 5 • 8:33 AM EDT • Business • ilo.org
Datavant, ID.me partner on digital identity verification for medical records

Datavant is partnering with identity verification company ID.me to help patients request their medical records faster and more easily via simple digital credentials. | Datavant has teamed up with ID.me to streamline medical records requests, enabling patients to verify their identities digitally and access records faster.

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Oct 5 • 8:30 AM EDT • Health • fiercehealthcare.com
Heartland Catfish Unveils New Website

Heartland Catfish Company recently launched a new website in celebration of its 30th anniversary. The site has been refreshed to focus on retail and food service partnerships, give a detailed look at the company’s products and processes and emphasize consumer education about the benefits of U.S. Farm-Raised Catfish as a versatile and healthy protein source. […]

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Oct 5 • 8:04 AM EDT • Business • deltabusinessjournal.com
Hunt Marketing Firm in Oxford Receives Accolade

For the third consecutive year, Hunt Marketing in Oxford has earned a place on the Inc. 5000 list of America’s fastest-growing private companies. Hunt ranked No. 4,009 on the 2026 list. “Being named to the Inc. 5000 list for a third time is meaningful because it validates the growth story we’re building,” said CEO and […]

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Oct 5 • 8:01 AM EDT • Business • deltabusinessjournal.com
Buck Motorsports Park & Entertainment Complex

The Buck Motorsports Park is a motorsports entertainment facility located in Quarryville (Buck), Pennsylvania.

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Oct 5 • 8:00 AM EDT • Entertainment • stadiumjourney.com
Scientists uncover recurrent patterns within chaotic quantum behavior

Many complex quantum systems rapidly lose the recognizable patterns of their initial states as their components interact. To describe patterns of regular and chaotic motion in specific systems, physicists ...

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Oct 5 • 8:00 AM EDT • Science • phys.org
Lexology Index Recognizes Five Hecker Fink Partners in 2026 Business Crime Defence Guide

Hecker Fink Partners Shawn Crowley, Jenna Dabbs, Mike Ferrara, Sean Hecker, and Amy Jeffress have been recognized in the Lexology Index guide for Business Crime Defence. The 2026 guide honors leading lawyers worldwide who “stand out among peers for their exceptional work representing companies, corporate officers, and individuals in criminal litigation arising from their business activities.”

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Oct 5 • 8:00 AM EDT • Business • heckerfink.com
Indonesia and China to strengthen science and education cooperation

Indonesia and China plan to expand cooperation in higher education and science to advance innovation and technology adoption.

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Oct 5 • 8:00 AM EDT • Science • tvbrics.com
Innovation That Solves: From Business Needs to AI Solutions

Targeted AI innovation transforms business challenges like hydrocarbon compliance into effective technological solutions, writes Jorge Mandujano.

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Oct 5 • 8:00 AM EDT • Business • mexicobusiness.news
The AI Advantage Minnesota Has Been Building for Decades

Software companies used to defend themselves in a handful of reliable ways. They built useful features, made their products easy to use and counted on the hassle of switching platforms to keep their customers from leaving. A new company that wanted to compete had to invest months, sometimes even years, of engineering time to catch

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Oct 5 • 7:46 AM EDT • Business • tcbmag.com
‘An anchor’: Oakshire fans celebrate, grieve as business prepares to shut down

Oakshire Public House has been a gathering space in the Whiteaker neighborhood since 2013 and holds many individual and community memories. Oakshire as a company is closing, but it plans to transition the Public House to a new company in the next two months, keeping the location open through the process.

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Oct 5 • 7:26 AM EDT • Business • lookouteugene-springfield.com
Android Auto could soon stop working on millions of phones

Android Auto appears to be preparing another compatibility cutoff, with Android 10 users now being warned that support will end soon.

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Oct 5 • 7:22 AM EDT • Technology • androidauthority.com
Virtual care firm Populus Health Technologies names Catalano as chief revenue officer

Populus Health Technologies, a virtual care media and technology company, announced the appointment of Joe Catalano as chief revenue officer.

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Oct 5 • 7:10 AM EDT • Health • roi-nj.com
WISeSat.Space Completes Business Combination and Begins Nasdaq Trading

WISeSat.Space has completed its business combination with Columbus Acquisition Corp. and started trading on Nasdaq as SAIQ.

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Oct 5 • 6:56 AM EDT • Business • thequantuminsider.com
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.

Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️‍🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe

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Oct 5 • 6:47 AM EDT • Health • adamtooze.substack.com
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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Oct 5 • 6:44 AM EDT • Science • goldrushcam.com
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Oct 5 • 6:03 AM EDT • Politics • knoxnews.com
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Oct 5 • 5:45 AM EDT • Business • crainsdetroit.com