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Samsung’s Blood Pressure Monitoring Feature Now Available to U.S. Users in Samsung Health

Select Galaxy Watch users in the U.S. can now measure and track blood pressure using Samsung Health

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Mar 31 • 9:00 AM EDT • Technology • news.samsung.com
Samsung’s Blood Pressure Monitoring Feature Now Available to U.S. Users in Samsung Health

Select Galaxy Watch users in the U.S. can now measure and track blood pressure using Samsung Health

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Mar 31 • 9:00 AM EDT • Health • news.samsung.com
UD leads nation with five Goldwater Scholars

Students recognized for excellence in science, engineering and mathematics research

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Mar 31 • 8:00 AM EDT • Science • udel.edu
Scott Pemberton O Theory added to VanWood entertainment line up

SOUTH LAKE TAHOE, Calif. – VanWood Tahoe, hosted by the Boys & Girls Club of Lake Tahoe in partnership with Kirkwood Mountain Resort and EpicPromise, announced a featured live music experience as part of its inaugural...

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Mar 31 • 8:00 AM EDT • Entertainment • tahoedailytribune.com
New Discovery Challenges Long-Standing Theory On The Formation Of The Earth – Its Building Blocks Came From Right Here

New analysis suggests that Earth’s material originates exclusively from the inner Solar System.

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Mar 31 • 5:44 AM EDT • Science • iflscience.com
CCTV appeal after £20k in cash stolen from Northfield business

West Midlands Police says it believes the man in CCTV footage has links to Bromsgrove.

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Mar 31 • 5:08 AM EDT • Business • bbc.com
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Mystery Of Odd Flashes In Pre-Satellite Sky Gets Odder, With Similar Puzzle Found At Separate Observatory In Hamburg

Looking at images of the sky taken before the first satellite was launched, one team believes they may have found objects floating above the Earth. Another study, based on a separate observatory in Hamburg, has now found a similar phenomenon.

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Mar 31 • 5:01 AM EDT • Science • iflscience.com
What Happens If You Drill Into Magma Beneath an Active Volcano? Scientists Accidentally Found Out In 2009

The drill cuttings contained fresh volcanic glass that “act like time capsules”.

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Mar 31 • 4:56 AM EDT • Science • iflscience.com
SF Supervisor Jackie Fielder on leave due to mental health condition; her staff set to take over

San Francisco Supervisor Jackie Fielder's office revealed she has been navigating a mental health condition.

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Mar 31 • 12:33 AM EDT • Health • abc7news.com
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Connections: Sports Edition today: Hints and answers for March 31, 2026, puzzle No. 554

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

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Mar 31 • 12:00 AM EDT • Sports • nytimes.com
Military investigating after Kid Rock brags about U.S. Army helicopters flying over his home, will take ‘appropriate action’ if in violation

The military is investigating after Kid Rock bragged about U.S. Army helicopters flying over his Nashville mansion, and say they will take ‘appropriate action’ if in violation.

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Mar 30 • 10:41 PM EDT • Entertainment • ew.com
Donation-based Pound Fitness class in Moundsville raises awareness of women’s heart health

The beat of drumsticks and music filled Miller Chiropractic and Wellness Center in Moundsville on Monday evening as women took part in a donation-based “Pound F

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Mar 30 • 10:36 PM EDT • Health • wtov9.com
WA now can bet on college teams, but with conditions

Gov. Bob Ferguson expanded tribal sports betting to include college teams.

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Mar 30 • 10:21 PM EDT • Sports • seattletimes.com
Complicated politics of license plate readers

Senior columnist Caris Gray argues that while license plate readers can be beneficial to public safety, they should not be used by the APD for fear of ICE compliance.

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Mar 30 • 9:32 PM EDT • Politics • thedailytexan.com
How to Watch Messi and Argentina vs Zambia Live on beIN SPORTS

The Argentina National Team heads into its second match of this FIFA international window with a clear objective: fine-tune details and continue building its foundation ahead of the 2026 World Cup. After facing Mauritania, the team led by Lionel Scaloni now takes on Zambia in what serves as a final test before key decisions are made.

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Mar 30 • 8:00 PM EDT • Sports • beinsports.com
There may be 10 times as many citizen scientists in Australia as we thought – and that’s great news for science

Citizens have contributed to science in Australia for many decades – and the field is now undergoing rapid growth

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Mar 30 • 6:41 PM EDT • Science • theconversation.com
Jim Bob and Michelle Duggar are 'heartbroken' following son Joseph's arrest

Jim Bob and Michelle Duggar have spoken out following their son Joseph's arrest in March.

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Mar 30 • 6:14 PM EDT • Entertainment • ew.com
Quest shows how energy crisis could spread across globe
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Mar 30 • 5:00 PM EDT • Business • cnn.com
‘I think that MAGA is dying’: Inside the youth movement at CPAC

Last year’s meeting struck a triumphant tone, as Elon Musk cranked a chrome chain saw onstage. But for the past several years a younger crowd has declared the event passé.

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Mar 30 • 3:31 PM EDT • Politics • seattletimes.com
Why I (Almost) Regretted My Lower Blepharoplasty

After I experienced some debilitating complications, I started reflecting on why I felt the need to get plastic surgery in the first place.

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Mar 30 • 3:13 PM EDT • Technology • thecut.com
Automated Ball-Strike challenge system making an impact, Tony Vitello gets a reality check and Blue Jays start hot
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Mar 30 • 2:02 PM EDT • Sports • sports.yahoo.com
San Francisco Supervisor Jackie Fielder to take leave over "mental health condition," staff says
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Mar 30 • 1:44 PM EDT • Health • cbsnews.com
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‘Race for the future’: Which countries — and what values — will prevail in science?

In a Yale visit, Harvey Fineberg, a renowned health policy researcher, discussed how the U.S. can keep pace in the global science “race” — and why it will benefit all of humankind.

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Mar 30 • 1:27 PM EDT • Science • news.yale.edu
Foundation Gaming & Entertainment Announces Sponsorship of New MPB Original Series “Southern Dish”

Foundation Gaming & Entertainment, a Mississippi-based hospitality and gaming company, is pleased to announce its sponsorship of Mississippi Public Broadcast...

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Mar 30 • 10:35 AM EDT • Entertainment • businesswire.com
May elections come at time of war on two fronts, Starmer says

At campaign launch, PM acknowledges concern over events in Ukraine and Iran as well as over rising cost of living

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Mar 30 • 10:11 AM EDT • Politics • theguardian.com
Where to watch Cleveland Guardians vs. Los Angeles Dodgers: Live stream, start time, TV Channel, odds for Monday, March 30

The Dodgers and Guardians begin their series on Monday night at Dodger Stadium.

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Mar 30 • 10:10 AM EDT • Sports • sports.yahoo.com
Iran says its expelled ambassador won’t leave Lebanon as political tensions soar

BEIRUT (AP) — Iran on Monday defied Lebanon’s expulsion order for its ambassador by saying he would stay, further increasing tensions in a country in the crosshairs of the latest fighting bet…

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Mar 30 • 8:45 AM EDT • Politics • thehill.com
Fourth Texas Area Planetary Science Meeting Returns in August 2026

The 4th Texas Area Planetary Science Meeting (TAPS) will be held on August 20–21, 2026, at the Commons Conference Center at The University of Texas at Austin.

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Mar 30 • 8:00 AM EDT • Science • lpi.usra.edu
Who could get Northern Ireland chance in Wales?

After their World Cup dreams came to an end in Italy, who could get a chance for Northern Ireland in Wales on Tuesday?

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Mar 30 • 2:33 AM EDT • Sports • sports.yahoo.com
Connections: Sports Edition today: Hints and answers for March 30, 2026, puzzle No. 553

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

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Mar 30 • 12:03 AM EDT • Sports • nytimes.com
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Georgia State Senate candidate to resume campaigning after life-threatening health event

Georgia Senate candidate Lanny Thomas shared an update on his condition and plans to continue campaigning on Sunday.

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Mar 29 • 1:34 PM EDT • Health • newschannel9.com
NH's Business: The potential of data centers in NH

Fred Kocher sits down with Radim Bartos with the University of New Hampshire's Department of Computer Science to talk about the potential of new data centers in New Hampshire.

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Mar 29 • 10:04 AM EDT • Business • wmur.com
Apple CEO Says Get Off Your Phone (And Science Agrees With Him)

Smartphone dependence can have significant negative effects on both mental and physical health, which is why it's good to limit screen time to just a few hours.

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Mar 29 • 9:17 AM EDT • Science • bgr.com
McDonald’s breaking ground soon, city officials say

A McDonald’s restaurant will soon be breaking ground in Herculaneum and is expected to be opening in December 2025

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Mar 29 • 8:30 AM EDT • Business • myleaderpaper.com
Phil Weiser wins top spot in Colorado’s Democratic gubernatorial primary at party’s state assembly
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Mar 28 • 11:59 PM EDT • Politics • 9news.com
Reds 3B Eugenio Suarez uses ABS challenge to counter back-to-back blown calls from umpire C.B. Bucknor
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Mar 28 • 9:58 PM EDT • Sports • sports.yahoo.com
Louisville police shoots, kills woman in mental health crisis

A woman was shot and killed by two officers in Louisville after she allegedly charged at them with a large, sharp object while experiencing a mental health crisis.

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Mar 28 • 6:42 PM EDT • Health • fox56news.com
Saturday Sports: Lacrosse season has returned to the North Country

Here’s a recap of your North Country sports this Saturday.

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Mar 28 • 6:19 PM EDT • Sports • kbtx.com
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How The Rollout Of Nine MLB Regional Sports Networks Came Down To The Wire

Fans of Major League Baseball were left to scramble on where to find nine teams on television on Opening Day. Here's how it happened.

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Mar 28 • 1:45 PM EDT • Sports • forbes.com
📸 This week's kit news 👕

Official releases, leaks and great finds: OneFootball rounds up all the kit news of the week.Arsenal (leak) 🔴The cloth of an English champion? The Gunners’ new home shirt should look like this (F...

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Mar 28 • 9:00 AM EDT • Sports • sports.yahoo.com
Bayern Munich officially renews two injured talents

The duo will continue to focus on their recoveries.

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Mar 28 • 1:30 AM EDT • Sports • sports.yahoo.com
Trey Hendrickson was "looking forward" to playing with Maxx Crosby

Less than 24 hours after the Ravens' trade for Maxx Crosby fell through, the team agreed to terms with Trey Hendrickson.

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Mar 27 • 5:02 PM EDT • Sports • nbcsports.com
BravesVision is officially on DIRECTV

The Atlanta Braves announced another major carriage agreement hours before Opening Day.

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Mar 27 • 3:32 PM EDT • Sports • sports.yahoo.com
CPAC draws conservatives to Texas amid Iran war, Republican battle for U.S. Senate nomination

The influential Conservative Political Action Conference, or CPAC, is underway in Grapevine, Texas. While the annual event draws attendees and speakers from all over, a host of Texans — including Gov. Greg Abbott, U.S. Senate hopeful Ken Paxton and state Sen. Bryan Hughes — are scheduled to speak on Friday.

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Mar 27 • 9:40 AM EDT • Politics • houstonpublicmedia.org
A Bremerton bakery closed by a 'particularly scary' crime

A Bremerton business launch was cut short by stalking, a 'particularly scary' crime one resident is speaking out about.

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Mar 27 • 7:15 AM EDT • Business • kitsapsun.com
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Trump says he wants to send federalized troops to L.A., San Francisco

Trump called on the mayors and governors of several blue cities and states to allow troops to 'come in and stop the crime,' and specifically called out Los Angeles and San Francisco.

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Mar 26 • 5:43 PM EDT • Politics • latimes.com
Movie Review: 'Two Prosecutors' is a perfect nightmare of state corruption

Sergei Loznitsa’s “Two Prosecutors” is a nightmare of government corruption so perfectly composed that, by the time it reaches its chilling conclusion, you feel nearly as entrapped as its young

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Mar 26 • 12:42 PM EDT • Entertainment • yakimaherald.com
What to know about the "wild, wild West" of viral peptide health claims
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Mar 26 • 10:13 AM EDT • Health • cbsnews.com
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ND Sports Scores for the week of March 23

Sports scores for the ND high school and college teams for the week of 3/23/2026

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Mar 26 • 12:29 AM EDT • Sports • kfyrtv.com
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Giants' 2026 MLB Opening Night starting lineup snaps historic left field streak

Heliot Ramos is the first San Francisco Giants player since Barry Bonds to open consecutive MLB seasons in left field.

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Mar 25 • 3:23 PM EDT • Sports • nbcsportsbayarea.com
Trump names Jensen Huang, Mark Zuckerberg to 13-member science and tech council

Trump has made securing U.S. leadership in artificial intelligence a central priority of his second term.

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Mar 25 • 10:12 AM EDT • Science • detroitnews.com
Trump Retained Classified Documents Because Of His ‘Business Interests,’ Jack Smith Alleged

Trump allegedly showed a classified map to people aboard his private plane, Smith found during his investigation.

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Mar 25 • 8:52 AM EDT • Business • forbes.com
Long lines persist at some U.S. airports despite ICE arrival

The Trump administration’s deployment of ICE officers to more than a dozen U.S. airports appeared to have a limited effect on reducing security lines.

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Mar 24 • 8:00 PM EDT • Politics • washingtonpost.com
Fact check: The lies Trump is using to sell his latest attack on mail-in voting

CNN debunks four of Trump’s most frequently repeated false claims about mail‑in voting.

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Mar 24 • 3:36 PM EDT • Politics • cnn.com
WATCH LIVE: Senate meets as lawmakers consider deal to fund Homeland Security
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Mar 24 • 11:44 AM EDT • Politics • pbs.org
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These Creatures Have One Cell and No Brain. Scientists Just Discovered They Can Learn.

In 1897 Russian physiologist Ivan Pavlov proved that animals can be trained using associative learning. A new study finds that even single-celled organisms can behave like “Pavlov's dog.”

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Mar 24 • 8:30 AM EDT • Science • popularmechanics.com
Blount: Online sports betting proposal has little support in Senate, would cost casino industry

Sen. David Blount, chairman of the Gaming Committee in the Senate, says a proposal to legalize online sports betting lacks support in the Senate, and could harm the state's casino tourism industry, which provides thousands of jobs and millions in state revenue. Blount also discusses proposed, and recently enacted, changes to the Public Employee Retirement System, and proposals to increase tax credits for private schools.

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Mar 24 • 7:00 AM EDT • Sports • mississippitoday.org
How COVID turned America against science — and what it will take to win it back

Tony Fauci was not just jerking the country around.

fortune.com logo
Mar 24 • 5:00 AM EDT • Science • fortune.com
"Patriotic Kenny" facing health problems, according to his social media
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Mar 23 • 11:40 AM EDT • Health • cbsnews.com
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Fire destroys 30,000 square feet of Aledo plating business, no injuries reported
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Mar 22 • 5:56 PM EDT • Business • wqad.com
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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Chappell Roan reacts to claims her security made Jude Law's 11-year-old daughter cry: 'I do not hate children'

Chappell Roan has responded to claims that her security guard made Jude Law's 11-year-old daughter cry after she got excited when she spotted the singer in a hotel: 'I do not hate children— that is crazy.'

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Mar 22 • 12:41 PM EDT • Entertainment • ew.com
AI was everywhere at gaming’s big developer conference

Developers say it removes the craft from making games.

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Mar 22 • 8:00 AM EDT • Technology • theverge.com
OPEN THREAD

The Daily Merengue is a place where you can feel free to discuss all things football. Do not be alarmed by the overt RMCF bias. It’s in the name! Shoutout to the mods who do a fantastic job Kung_Fu_Zizou, Juninho, NeRObutBlanco, Felipejack, Ezek Ix and yours truly, Valyrian Steel. Gameday!! Huge clash in the context […]

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Mar 22 • 2:39 AM EDT • Sports • sports.yahoo.com
When health insurance costs $2,500 per month, families make tough choices

A self-employed couple already had to dip into retirement savings for health costs. Now, they are skipping vacations and canceling streaming to afford health insurance.

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Mar 21 • 7:00 AM EDT • Health • npr.org
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The end of the ISS is looming, and the US could have a big problem

As the US sets its sights on establishing a permanent base on the moon, its foothold in an area of space much closer to home is growing more uncertain.

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Mar 21 • 6:00 AM EDT • Technology • cnn.com
Michigan vs Saint Louis prediction, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 1 Michigan vs No. 9 Saint Louis in the 2026 NCAA Tournament on March 21

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Mar 20 • 8:21 PM EDT • Sports • usatoday.com
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Apple Has Unveiled 9 New Products This Month

Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.

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Mar 20 • 5:39 PM EDT • Technology • macrumors.com
Arsenal and Manchester City lineups: James Trafford to start, Mikel Arteta dodges Kepa, David Raya question

Pep Guardiola will continue to rely on his backup keeper in the cup competition while Arteta played coy

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Mar 20 • 4:39 PM EDT • Sports • cbssports.com
Value investors see mispriced opportunities from sports to fertilizer

Value investors pitched a mix of stock ideas in disparate corners of the market at the Value Invest conference in New York on Thursday.

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Mar 20 • 4:04 PM EDT • Sports • cnbc.com
Fantasy Baseball Rankings 2026: Breakouts by model that called Jacob Wilson's impressive season

The SportsLine model reveals its top 2026 Fantasy baseball breakouts after nailing Jacob Wilson's huge 2025 season

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Mar 19 • 2:05 PM EDT • Sports • cbssports.com
What to watch this week in New Orleans theater: ‘Gatsby,’ ‘Streetcar,’ ‘Little Shop,’ more

Step into the Jazz Age with a lavish musical adaptation of F. Scott Fitzgerald's classic tale at the Saenger Theatre. Don't miss the chance to witness Jay Gatsby's larger-than-life story come alive on stage!

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Mar 19 • 11:00 AM EDT • Entertainment • nola.com
Looking for Answers Before Birth: How 2 UT Health Sciences Researchers Are Re-examining Childhood Obesity

Childhood obesity is often framed as a problem of habits, including what children eat, how much they move, and the environments in which they grow up.

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Mar 19 • 10:00 AM EDT • Health • news.uthsc.edu
Pittsburgh premiere of 'Eureka Day' stage comedy tackles vaccine politics

Jonathan Spector’s play “Eureka Day,” making its Pittsburgh premiere at City Theatre, depicts what happens to even a group of people who might seem highly compatible when a single hot issue scorches the earth between them.

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Mar 19 • 5:30 AM EDT • Politics • wesa.fm
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Jonathan Kuminga makes 75-foot shot, NBA's 6th-longest on record, as Hawks win 11th straight
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Mar 18 • 11:40 PM EDT • Sports • sports.yahoo.com
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2 Arizona resorts, Hawaiian BBQ spot cited by health inspectors

Two Arizona resorts and one Phoenix Hawaiian BBQ spot were among places cited by health code inspectors in this week's Dirty Dining report.

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Mar 18 • 10:56 PM EDT • Health • azfamily.com
Andy Dalton trade: Eagles acquire veteran QB, send seventh-round pick to Panthers

Dalton will join the sixth team of his NFL career

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Mar 18 • 3:50 PM EDT • Sports • cbssports.com
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Healthy Returns: Stopping GLP-1s raises risk of heart attack, stroke and death, study says

Research finds that even short gaps in treatment with a GLP-1 can drive up risks of heart attack, stroke and death in patients with Type 2 diabetes.

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Mar 18 • 2:06 PM EDT • Health • cnbc.com
Shohei Ohtani will return to the mound for Dodgers Wednesday

Roberts said the plan is for Ohtani to pitch in one more preseason game

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Mar 18 • 9:20 AM EDT • Sports • spectrumlocalnews.com
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Meet the Mid-Penn Conference winter sports all-stars

See who made the Mid-Penn Conference all-star winter teams in basketball and wrestling.

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Mar 18 • 4:01 AM EDT • Sports • sports.yahoo.com
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How sports traditions like March Madness can support brain health

Three experts from the University of Kentucky say the answer may be yes. Research shows that staying mentally, socially and emotionally engaged can help support long-term brain health. Activities tied to sports — like predicting tournament outcomes, reminiscing about past games or gathering with friends and family to watch — can stimulate memory, strengthen cognitive skills and foster meaningful social connections.

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Mar 18 • 4:00 AM EDT • Sports • uknow.uky.edu
March Madness 2026 bracket: NCAA Tournament picks, predictions by longtime college basketball model

SportsLine's model has nailed 25 first-round upsets by double-digit seeds and revealed its optimal NCAA Tournament bracket 2026

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Mar 17 • 1:34 PM EDT • Sports • cbssports.com
California governor candidate sends scathing letter to USC

"You can't escape the detestable outcome."

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Mar 17 • 12:02 PM EDT • Politics • sfgate.com
Calif. governor candidate calls out 'chilling' debate format

"You can't escape the detestable outcome."

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Mar 17 • 12:02 PM EDT • Politics • sfgate.com
Judge blocks Kennedy's changes to US childhood vaccine schedule

Kennedy had slashed the number of recommended vaccines from 17 to 11, sparking a backlash from health experts.

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Mar 17 • 10:50 AM EDT • Health • bbc.com
Attaining Optimal Gut Health: Doctor Separates Facts From Myth

Dr. Roshini Raj, gastroenterologist at New York University Langone Medical Center, joins TODAY to talk about what’s best for your digestive and gut health. She also separates facts and fiction when it comes to lemon water detoxing your stomach, whether you can have too much fiber and more.

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Mar 17 • 9:29 AM EDT • Health • today.com
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Mastercard to Acquire BVNK to Connect On-Chain Payments and Fiat Rails

Mastercard today announced a definitive agreement to acquire BVNK, a leader in stablecoin infrastructure.

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Mar 17 • 8:00 AM EDT • Business • businesswire.com
Japan's Idemitsu to invest $500 million in Australian Midocean to enter LNG business

Idemitsu Kosan , Japan's second-biggest oil refiner, said on Tuesday it ​will invest $500 million in Australia's ‌MidOcean Energy as part of a move towards a full-scale entry into the LNG ​business.

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Mar 17 • 5:26 AM EDT • Business • reuters.com
The Pentagon provided a rare inside look at Palantir's Project Maven

Cameron Staley, the Pentagon's chief digital and AI officer, praised Palantir's tool for modernizing warfighting.

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Mar 17 • 5:07 AM EDT • Business • businessinsider.com
Exclusive: OpenAI courts private equity to join enterprise AI venture, sources say

OpenAI is in advanced talks with private equity firms including TPG , Advent International, Bain Capital and Brookfield Asset Management to form a joint ​venture that would distribute its enterprise products across the firms' portfolio companies and beyond, four people familiar with the matter said.

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Mar 16 • 9:25 AM EDT • Business • reuters.com
Ireland Contracting Nightly Sports Call: Mar. 15, 2026
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Mar 15 • 11:35 PM EDT • Sports • cbsnews.com
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March Madness Final Four predictions to win 2026 NCAA Tournament regions

Now that the NCAA Tournament bracket has been unveiled, we know the paths teams must take to reach Indianapolis and the Final Four.

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Mar 15 • 7:16 PM EDT • Sports • usatoday.com
Men’s March Madness Selection Sunday Live Updates: Seeds, Matchups and Analysis

March Madness is finally upon as the selection committee will name the 68 teams competing in the NCAA tournament. Follow along with SI.

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Mar 15 • 5:01 PM EDT • Sports • si.com
Ashley Spivey, entrepreneur and small business owner

Congratulations to Ashley Spivey, entrepreneur and small business owner for being named one of our 40 Under 40!

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Mar 15 • 10:00 AM EDT • Business • ourmidland.com
Views from Pirates Spring Training, the NCAA Tournament, and Steelers free agency
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Mar 15 • 6:31 AM EDT • Sports • cbsnews.com
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Broncos Country underwhelmed by Broncos free agency moves

Based on results of our FanDuel SB Nation Reacts survey earlier this week, it is pretty clear what Denver fans think of the team signing ONLY Broncos free agents. Not thrilled. At the time of the survey, the Broncos had re-signed Alex Palczewski, Adam Trautman, Alex Singleton, Nate Adkins, and Justin Strnad. Since then, they […]

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Mar 14 • 7:00 AM EDT • Sports • sports.yahoo.com
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Contributor: Federal power grabs on elections are not about fraud

Trump has called the SAVE Act his top priority. But why? His commission found no widespread problem that needed solving.

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Mar 14 • 6:00 AM EDT • Politics • latimes.com
Figuring out why AIs get flummoxed by some games

When winning depends on intuiting a mathematical function, AIs come up short.

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Mar 13 • 5:47 PM EDT • Technology • arstechnica.com
82 million can't afford health care, but Hegseth gets lobster

More than 82 million Americans are having to skip meals, borrow money or cut back on utilities so they can afford health care.

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Mar 13 • 4:31 AM EDT • Health • usatoday.com
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WordPress launches an in-browser website creator

You don’t need a WordPress account or host to create a private site in your browser.

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Mar 12 • 11:15 AM EDT • Technology • theverge.com