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Chicago Comic & Entertainment Expo Extra Service

To accommodate passengers attending the Chicago Comic and Entertainment Expo (C2E2) taking place March 27-29, 2026, at McCormick Place, the South Shore Line will be offering extra train service on Saturday, March 28. As McCormick Place is not a scheduled stop, passengers traveling to C2E2 should purchase tickets for Museum Campus. MCCORMICK PLACE SERVICE: Please click here for special […]

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Mar 23 • 3:53 PM EDT • Entertainment • mysouthshoreline.com
Federal judge sides with Wisconsin in transgender health care suit

A U.S. judge ruled in favor of Wisconsin and 20 other states challenging a Trump administration declaration that tried to limit care for trans youth.

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Mar 23 • 3:23 PM EDT • Health • jsonline.com
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Top business leader demands end to stalemate over City Council's pick for zoning chair

Chicagoland Chamber of Commerce President Jack Lavin said more than 40 development projects have been stalled by City Council's failure to agree on new permanent chair for the powerful Zoning Committee. He wants Mayor Brandon Johnson to forge a compromise to break the stalemate.

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Mar 23 • 2:47 PM EDT • Business • chicago.suntimes.com
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Ben White called up for England: Why Real Madrid's Trent Alexander-Arnold continues to be frozen out

Manager Thomas Tuchel has one of the most skilled right-backs in the world to call upon, but hasn't figured out a way to make him worth it

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Mar 23 • 2:30 PM EDT • Sports • cbssports.com
Health inspectors found thawed seafood, food stored in buckets leading to temporary closure of Mama Tina’s Gumbo

Houston health inspectors investigating a customer illness complaint after eating Mama Tina’s Gumbo at the Houston Livestock Show & Rodeo found thawed seafood labeled “keep frozen” and learned the gumbo had been moved to a freezer at an unlicensed off-site location without temperature logs before being served, according to Houston Health Department records obtained by KPRC 2 News.

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Mar 23 • 2:14 PM EDT • Health • click2houston.com
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Kraken owners take step toward a Seattle Sonics NBA team

Seattle Kraken ownership has launched a parent brand, One Roof Sports and Entertainment, that could include owning an NBA expansion Seattle Sonics team.

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Mar 23 • 2:12 PM EDT • Sports • sports.mynorthwest.com
Bachelorette suitor from canceled season drove car in Madison Cawthorn crash

A 'Bachelorette' suitor from Taylor Frankie Paul's now-scrapped season was the driver in the 2014 car crash that paralyzed former Republican congressman Madison Cawthorn.

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Mar 23 • 2:08 PM EDT • Entertainment • ew.com
Kraken create One Roof Sports & Entertainment in expected pursuit of NBA expansion team

Kraken owner Samanatha Holloway created the umbrella brand One Roof Sports & Entertainment on Monday, a transaction that gives her a majority stake in Seattle’s Climate Pledge Arena and is a likely precursor to a bid for an NBA expansion franchise.

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Mar 23 • 2:06 PM EDT • Sports • sportsbusinessjournal.com
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Kraken create One Roof Sports & Entertainment in expected pursuit of NBA expansion team

Kraken owner Samanatha Holloway created the umbrella brand One Roof Sports & Entertainment on Monday, a transaction that gives her a majority stake in Seattle’s Climate Pledge Arena and is a likely precursor to a bid for an NBA expansion franchise.

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Mar 23 • 2:06 PM EDT • Entertainment • sportsbusinessjournal.com
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Brian Doherty, 57, Dies; Chronicled Libertarians and Other Outsiders

Fascinated by the fringes, he wrote a definitive history of libertarianism and books about underground comics and the Burning Man festival.

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Mar 23 • 1:35 PM EDT • Politics • nytimes.com
On eve of SD 14 election, Dems still lag in early vote, but data suggests possible victory in defeat

Even if Democrat Brian Nathan loses, an overperformance could send a big message.

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Mar 23 • 12:20 PM EDT • Politics • floridapolitics.com
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Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech

Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology ‌that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make ‌cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits ​that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.

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Mar 23 • 12:02 PM EDT • Technology • finance.yahoo.com
Trump sued by historic preservation groups to block Kennedy Center changes

A coalition of preservation groups is suing to stop major physical changes at the Kennedy Center under President Donald Trump’s renovation plans. On Monday, the groups filed a lawsuit against

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Mar 23 • 11:41 AM EDT • Entertainment • lancasteronline.com
Politics & Film: ‘Fahrenheit 9/11,’ March 27

Join Politics & Film for a screening of Michael Moore's award-winning documentary “Fahrenheit 9/11” on Friday, March 27 at 5:00 p.m. in Wehr Life Sciences 111.

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Mar 23 • 11:26 AM EDT • Politics • today.marquette.edu
Epic says it has uncovered rot in patient record sharing. Will HHS act?

A recent Epic lawsuit revealed a company allegedly posed as a provider to access patient records for law firms, prompting a call for increased oversight.

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Mar 23 • 10:48 AM EDT • Health • statnews.com
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2nd Car Show Scheduled at Sangertown Square

Racing fans and families can check out high-performance cars and meet local drivers at the Mall Car Show at Sangertown Square.

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Mar 23 • 10:38 AM EDT • Entertainment • wktv.com
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Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return

A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.

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Mar 23 • 10:04 AM EDT • Science • scitechdaily.com
Shorebird Science and Conservation Collective Shows Big Data Can Protect Birds

New research published in the journal Conservation Biology provides a model for big data to inform conservation.

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Mar 23 • 10:00 AM EDT • Science • nationalzoo.si.edu
2026 Fantasy Baseball Rankings: Sleepers, busts, breakouts from model that nailed Cal Raleigh's epic season

SportsLine simulated the entire MLB season 10,000 times and identified 2026 Fantasy baseball sleepers, breakout and busts

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Mar 23 • 9:37 AM EDT • Sports • cbssports.com
Intel Core Ultra 7 270K Plus & Core Ultra 5 250K Plus Official Benchmarks: Faster Than 14900K & Comparable To Ryzen X In Gaming, Much Faster In Apps, Superb Value

Intel shared official benchmarks of its Core Ultra 7 270K Plus & Core Ultra 5 250K Plus in gaming, apps, and more, against AMD Ryzen CPUs.

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Mar 23 • 9:00 AM EDT • Technology • wccftech.com
Marquette Law School adds Aaron Hernandez to National Sports Law Institute leadership

Aaron Hernandez, currently at Arizona State University’s Sandra Day O’Connor College of Law, will be joining the faculty at Marquette University Law School as associate professor of practice and director of the National Sports Law Institute. Marquette is led in the area of sports law by Matt Mitten, professor of law, and Paul Anderson, associate…

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Mar 23 • 9:00 AM EDT • Sports • today.marquette.edu
A surprising foam discovery could change everyday products

Foams have long baffled scientists because liquid drains from them far sooner than theory predicts. New research shows the reason: the bubbles don’t stay put—they rearrange, opening pathways for liquid to escape. The key factor is the pressure needed to shift bubbles, not just push liquid through them. This insight reshapes how we understand foams and could improve everyday products.

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Mar 23 • 8:00 AM EDT • Science • sciencedaily.com
Browns coach Todd Monken’s strong suit is blunt honesty without the politics

Monken's authenticity and commitment are strengths, said the Southern Miss AD who hired him for his only other head-coaching job in 2013.

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Mar 23 • 7:00 AM EDT • Politics • nytimes.com
Spurs vs. Heat odds, prediction, time: 2026 NBA picks for Monday, March 23 from proven model

SportsLine's proven model has revealed its San Antonio Spurs vs. Miami Heat predictions and NBA picks today

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Mar 23 • 6:01 AM EDT • Sports • cbssports.com
Today's hefty Crimson Desert patch includes "beginning of improvements" to keyboard and mouse controls, plus much more

Pearl Abyss has detailed a rather chunky patch for Crimson Desert, after its launch last week was marred by multiple issues and AI controversies.

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Mar 23 • 5:52 AM EDT • Technology • eurogamer.net
David Gallo opens up about why AI data centers, private equity are good for his company

After Katrina, David Gallo led his family's company, Gallo Mechanical, through a geographic expansion that helped grow the company to nearly $500 million in revenues and more than 700 employees. Last year, he led the 80-year-old business through a sale to a private equity firm. In this week's Talking Business, he explains why it was a good thing

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Mar 23 • 5:00 AM EDT • Business • nola.com
The politics of disability at the Academy Awards

Throughout history, disabled bodies have been portrayed as a burden.

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Mar 23 • 4:28 AM EDT • Politics • thepanthernewspaper.org
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Turning coal to medicines: Chinese scientists bring a 160-year-old dream to life

Study cracks a puzzle that has baffled scientists and will reshape modern medicine production as the world reels from a global oil shortage.

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Mar 23 • 2:23 AM EDT • Science • scmp.com
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Socialist Emmanuel Grégoire elected Paris mayor in runoff vote

Emmanuel Grégoire has won the Paris mayoral race and takes over from fellow Socialist Anne Hidalgo. On Sunday, he sealed the moment by riding a city bike to City Hall.

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Mar 23 • 1:54 AM EDT • Politics • apnews.com
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Connections: Sports Edition today: Hints and answers for March 23, 2026, puzzle No. 546

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

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Mar 23 • 12:50 AM EDT • Sports • nytimes.com
Power Play Primed – Hurricanes 5, Penguins 1

The Carolina Hurricanes scored three power play goals and dominated the Pittsburgh Penguins, 5-1 on Sunday afternoon in the Steel City. The Canes controlled the puck most of the game and were holding the Pens to a paltry 12 shots on goal until the Pens finally found some offense with five minutes and change to […]

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Mar 23 • 12:35 AM EDT • Sports • sports.yahoo.com
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Cursor acknowledges its new low-cost coding model has Chinese roots

Cursor says its new coding model builds on Kimi K2.5, a Chinese model it didn't mention at launch.

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Mar 23 • 12:35 AM EDT • Business • businessinsider.com
Everything you need to know about 'BTS: The Return,' the new Netflix documentary

On Friday, Netflix will release a documentary about the biggest band in K-pop, BTS. It is titled “BTS: The Return.” It is from director Bao Nguyen. He is known for his work on “The Stringer”...

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Mar 23 • 12:01 AM EDT • Entertainment • newstimes.com
Everything you need to know about 'BTS: The Return,' the new Netflix documentary

On Friday, Netflix will release a documentary about the biggest band in K-pop, BTS. It is titled “BTS: The Return.” It is from director Bao Nguyen. He is known for his work on “The Stringer”...

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Mar 23 • 12:01 AM EDT • Entertainment • greenwichtime.com
California Politics 360 Full Episode | Sexual abuse allegations against César Chávez

Civil rights leader Dolores Huerta broke her silence, saying she was also sexually abused by Chávez. It led to the birth of two children, a secret she kept for 60 years.

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Mar 22 • 11:25 PM EDT • Politics • kcra.com
Does PBS ‘Count of Monte Cristo’ Make Big Book Changes?

A recap of Episode 1 of the Sam Claflin and Jeremy Irons-led adaptation.

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Mar 22 • 11:00 PM EDT • Entertainment • northwestgeorgianews.com
24-year-old killed after shooting outside Last Call Sports Bar

24-year-old killed after shooting outside Last Call Sports Bar

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Mar 22 • 10:02 PM EDT • Sports • wapt.com
A DNA test ruled him out. He was convicted of murder anyway.

Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.

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Mar 22 • 9:57 PM EDT • Science • bostonglobe.com
Scientists Open Moon Rocks Locked Away Since 1972 – and Find Something Totally Unexpected

Decades after being sealed away, Apollo-era lunar samples are revealing unexpected chemical signatures that challenge long-standing assumptions about the Moon’s composition.

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Mar 22 • 9:32 PM EDT • Science • scitechdaily.com
Statue of Christopher Columbus installed on White House grounds

A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.

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Mar 22 • 9:09 PM EDT • Politics • cnn.com
Alabama vs. Texas Tech odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Texas Tech vs. Alabama picks for the NCAA Tournament 2026 second-round game on Sunday

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Mar 22 • 8:03 PM EDT • Sports • cbssports.com
Lessons from Binghamton led alumni award winner to public health

Clare Biging ’16 is an epidemiologist and public health advocate at the New York City Department of Health and Mental Hygiene.

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Mar 22 • 8:00 PM EDT • Health • binghamton.edu
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series

Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]

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Mar 22 • 7:00 PM EDT • Technology • news.samsung.com
Politics, protests and popular culture: The University of Minnesota community responds to ICE impact through memes and music

Outside Coffman Union on March 3, The University of Minnesota’s Students for a Democratic Society protested Immigration and Customs Enforcement’s presence in Minnesota and on campus, despite reports that Operation...

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Mar 22 • 6:52 PM EDT • Politics • mndaily.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • 29news.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • whsv.com
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Apple already has the perfect platform for deploying conversational AI

When Apple initially rolled out Apple Intelligence, the company was pretty openly against the idea of creating a Siri chatbot....

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Mar 22 • 6:10 PM EDT • Technology • 9to5mac.com
Fire destroys 30,000 square feet of Aledo plating business, no injuries reported
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Mar 22 • 5:56 PM EDT • Business • wqad.com
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UFL team signs former Alabama high school, Crimson Tide QB

The Thompson High School alumnus had been scheduled to play in the Indoor Football League on Sunday.

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Mar 22 • 4:51 PM EDT • Sports • al.com
Woman seeks help at Aurora business after suffering serious injuries in shooting

A woman collapsed inside an Aurora business while seeking help after she was shot Saturday night. Police are trying to determine what led up to it.

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Mar 22 • 4:23 PM EDT • Business • cbsnews.com
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Minnesota Wild, NHL mourn hockey writer Jessi Pierce after death in house fire

Pierce and her three children were killed in a house fire outside of Minneapolis early Saturday morning.

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Mar 22 • 3:56 PM EDT • Sports • sports.yahoo.com
‘We’ve got some unfinished business’: Corey Gipson reflects on historic Austin Peay season

Austin Peay men's basketball head coach Corey Gipson recently reflected on his 2025-26 season and revealed what makes Clarksville special.

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Mar 22 • 3:29 PM EDT • Business • clarksvillenow.com
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Student researchers bring Kentucky State University science to Posters-at-the-Capitol

With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]

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Mar 22 • 3:00 PM EDT • Science • state-journal.com
'Disgusting.' Democratic senator slams Trump's reaction to Mueller's death

Sen. Chris Murphy called President Donald Trump's response to the death of Robert Mueller "disgusting."

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Mar 22 • 2:20 PM EDT • Politics • usatoday.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Southern Living names top small towns, Florida snags 5 spots

St. Augustine named best small town in the Southern United States.

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Mar 22 • 1:46 PM EDT • Politics • floridapolitics.com
Kentucky vs. Iowa State odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Kentucky vs. Iowa State picks for the NCAA Tournament 2026 second-round game on Sunday

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Mar 22 • 1:03 PM EDT • Sports • cbssports.com
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Apple’s busy March continues with three notable arrivals this week

Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...

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Mar 22 • 11:47 AM EDT • Technology • 9to5mac.com
Arsenal vs. Manchester City live stream: How to watch EFL Cup final, odds, start time

This is Pep Guardiola's best chance at a trophy this season, and perhaps shift the momentum in the Premier League

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Mar 22 • 11:09 AM EDT • Sports • cbssports.com
Apple iPhone Fold Might Have A Sun Glare Problem

Given the already high reflectance of iPhone displays, Apple's use of a CoE filter on the iPhone Fold can lead to a sun glare problem.

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Mar 22 • 11:05 AM EDT • Technology • wccftech.com
VoidStealer malware steals Chrome master key via debugger trick

An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.

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Mar 22 • 10:32 AM EDT • Technology • bleepingcomputer.com
New Apple TV and HomePod Mini Remain 'Ready' to Launch

Apple has unveiled nine new products this month, but the wait continues for the next-generation Apple TV 4K and HomePod mini models. In his Power On newsletter today, Bloomberg's Mark Gurman said new versions of the Apple TV and HomePod mini have been "ready" since last year, but he reiterated that Apple has held off on releasing them until the more personalized version of Siri and other Apple Intelligence upgrades are released later this year.

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Mar 22 • 9:33 AM EDT • Technology • macrumors.com
It's not just vaccines — parents are refusing other routine preventive care for newborns

Doctors are alarmed that skepticism fueled by rising anti-science sentiment is increasingly reaching beyond vaccines to other proven, routine, preventive care for babies.

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Mar 22 • 9:26 AM EDT • Health • boston.com
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Inside a rare lab that's blazing a bold trail as it hunts for new drugs

A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.

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Mar 22 • 9:25 AM EDT • Technology • npr.org
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Inside a rare lab that's blazing a bold trail as it hunts for new drugs

A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.

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Mar 22 • 9:25 AM EDT • Health • npr.org
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Apple Has Released More Than 10 Products and Accessories This Month

It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.

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Mar 22 • 9:00 AM EDT • Technology • macrumors.com
Tantalizing Tech: The Goodies at Cyclingworld Europe 2026

Turbulence at Eurobike has led to a big boost for Cyclingworld. Here's some of the latest dream tech from the show.

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Mar 22 • 8:45 AM EDT • Technology • velo.outsideonline.com
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

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Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
Scientists twisted a mysterious superconductor and got a shocking result

A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Scientists Startled by What Happens When They Point Hubble at Comet

An extraordinary coincidence occurred when astronomers pointed the Hubble Space Telescope at a wayward comet.

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Mar 22 • 8:00 AM EDT • Science • futurism.com
Boys' basketball coach of the year: Mike LeDuc of Damien

The second-winningest coach in California high school history guided Damien to the state Division I championship.

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Mar 22 • 7:10 AM EDT • Sports • latimes.com
Colorado lawmakers can pass “Alyssa’s Act” to help coaches and parents monitor mental health (Opinion)

In 2019, we lost Alyssa after she struggled with her mental health following a series of concussions. We later learned that concussions can be linked to serious mental health challenges and an increase in suicide, especially in young people.

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Mar 22 • 7:01 AM EDT • Health • denverpost.com
Southland girls' basketball final rankings for 2025-26 seaosn

A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.

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Mar 22 • 6:05 AM EDT • Sports • latimes.com
Get ready to vote in the next Detroit Community Choice Awards

The awards program seeks to shine a light on outstanding businesses in Wayne, Oakland and Macomb counties.

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Mar 22 • 6:02 AM EDT • Business • freep.com
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Ron DeSantis says politics should be more than 'sugar high' entertainment

'If it's not leaving something that is durable, then it doesn't matter.'

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Mar 22 • 5:45 AM EDT • Politics • floridapolitics.com
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Ron DeSantis says politics should be more than 'sugar high' entertainment

'If it's not leaving something that is durable, then it doesn't matter.'

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Mar 22 • 5:45 AM EDT • Entertainment • floridapolitics.com
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In the Fight to Defend the Amazon, This Indigenous Community’s Secret Weapon Is Science

In the copper-rich mountains of southeastern Ecuador, Shuar people are combining ancestral knowledge and modern science to protect their forest from a Canadian mining giant.

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Mar 22 • 5:00 AM EDT • Science • insideclimatenews.org
EA-US Politics Podcast: Mr Trump Goes to War

50-minute analysis of the chaos and destruction of Donald Trump and his inner circle as self-declared "President of Peace" wages war on Iran

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Mar 22 • 4:02 AM EDT • Politics • eaworldview.com
Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC

Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.

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Mar 22 • 1:40 AM EDT • Sports • sports.yahoo.com
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Recap: Sporting KC suffers 4-1 loss to Colorado

Sporting Kansas City suffered a 4-1 loss to the Colorado Rapids on Saturday at Sporting Park. Shapi Suleymanov scored the lone goal for SKC in the defeat as the visitors prevailed behind a brace from Paxten Aaronson to go along with a goal from fellow Designated Player Rafael Navarro and

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Mar 22 • 12:49 AM EDT • Sports • sportingkc.com
The Business of Football: How many players do you need to win a World Cup anyway?

The English FA and the Premier League are having another row, as the club vs country debate rages on in English football

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Mar 22 • 12:02 AM EDT • Business • nytimes.com
Connections: Sports Edition today: Hints and answers for March 22, 2026, puzzle No. 545

Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.

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Mar 22 • 12:00 AM EDT • Sports • nytimes.com
Bridging medical realities in the study of technology and health

Anthropologist and MIT Associate Professor Amy Moran-Thomas studies medical technologies and how they fail to reach some communities. “What anthropology has to offer the world, and other knowledge systems, is the insights of people that might be missing from many accounts,” she says.

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Mar 22 • 12:00 AM EDT • Health • news.mit.edu
Person robbed at gunpoint outside Dracut business

Dracut police say two suspects in black robbed a man at gunpoint, then fled in a silver Ford Explorer, which was later found. No arrests announced.

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Mar 21 • 11:59 PM EDT • Business • nbcboston.com
Amanda Peet Shares Breast Cancer Diagnosis

Amanda Peet detailed her recent breast cancer diagnosis in a new essay, sharing that her health battle coincided with both of her parents' final months in hospice care.

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Mar 21 • 8:27 PM EDT • Health • eonline.com
Dana Walden unveils leaders of expanded Disney Entertainment

Dana Walden, the incoming President and Chief Creative Officer of The Walt Disney Company, has unveiled the new leadership structure for Disney Entertainment, bringing together the company’s streaming, film, and television businesses along with its games and digital entertainment division.

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Mar 21 • 8:00 PM EDT • Entertainment • ibc.org
More school-based health clinics fill growing needs

An increase in school-based health clinics is sweeping the states of Ohio and Michigan, following research that grounds positive health outcomes for ...

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Mar 21 • 8:00 PM EDT • Health • toledoblade.com
WHO verifies deadly hospital attack in war-torn Sudan

The World Health Organization (WHO) verified on Saturday a hospital attack in war-torn Sudan that killed 64 people.

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Mar 21 • 6:57 PM EDT • Health • news.un.org
Barber reflects on shooting outside of his business

A man was shot and killed outside a local business in Youngstown’s first homicide of the year yesterday afternoon.

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Mar 21 • 6:10 PM EDT • Business • wkbn.com
Trump continues to target Robert Mueller after his death

Mueller, who led the Russia investigation and the bureau after 9/11, remained a target of Trump years after his probe of possible election interference.

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Mar 21 • 6:05 PM EDT • Politics • washingtonpost.com
Illinois State, Wake Forest battle for NIT quarterfinal spot

Another prolific scoring performance by Juke Harris allowed Wake Forest to keep its season alive and the best game of Landon Wolf's career enabled Illinois State to continue playing.

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Mar 21 • 5:42 PM EDT • Sports • cbssports.com
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'Eager to announce': Gurnee Mills mall announces multiple new stores, entertainment options opening

The owner of Gurnee Mills mall announced that multiple new stores and entertainment options, including IKEA, will be opening at the shopping mall over the next several months.

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Mar 21 • 5:14 PM EDT • Entertainment • lakemchenryscanner.com
Report: PlayStation's Firesprite Studio Almost Made Breaking Bad VR, as Well as a New Sci-Fi Horror Game

From a canceled Breaking Bad VR experience to a secret sci-fi horror title, we delve into two shelved projects of PlayStation’s Firesprite.

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Mar 21 • 3:54 PM EDT • Technology • mp1st.com
Robert Mueller, former special counsel who led Trump-Russia probe, dies

A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.

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Mar 21 • 2:19 PM EDT • Politics • nbcnews.com
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Scientists Recruit Undergrad to Step Into Room Filled With Ravenous Mosquitoes for “Full-Body Massacre”

Researchers at Georgia Tech used undergraduate student Chris Zuo as bait in trials to study mosquito flight behaviors.

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Mar 21 • 2:00 PM EDT • Science • futurism.com
Robert Mueller, former FBI director and special counsel in Trump-Russia probe, dies

Robert Mueller, the former FBI director who led the historic probe into alleged collusion between Donald Trump’s 2016 campaign and the Russian government, has died, according to a family statement obtained by The New York Times and the Associated Press. He was 81.

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Mar 21 • 1:44 PM EDT • Politics • cnn.com
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Robert S. Mueller III, 81, Dies; Rebuilt F.B.I. and Led Trump Inquiry

After he concluded that Russia had interfered in the 2016 election, he became a target of the president’s anger.

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Mar 21 • 1:30 PM EDT • Politics • nytimes.com
Mojang Reveals Chaos Cubed Update Coming to Minecraft Later This Year With Tiny Takeover Release Date Set for Next Week

Mojang has unveiled more information about updates coming to Minecraft in 2026, including the release date for Tiny Takeover and a sneak peek at the Chaos Cubed game drop.

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Mar 21 • 1:24 PM EDT • Technology • ign.com
Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout

Spanberger will mull theirs and former Gov. Glenn Youngkin’s budget proposals ahead of a reconvened session on April 23.

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Mar 21 • 1:10 PM EDT • Health • wtop.com
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'The Bachelorette' canceled: Taylor Frankie Paul's season pulled after 2023 domestic violence video surfaces

Taylor Frankie Paul speaks out as controversy grows, with "The Bachelorette" canceled and filming paused on "Secret Lives of Mormon Wives."

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Mar 21 • 12:54 PM EDT • Entertainment • yahoo.com