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Supreme Court strikes down Watergate-era limits on campaign funds for political parties
The Supreme Court ruled again that campaign funding is free speech protected by the 1st Amendment.
I Tried Sony's $260 Wearable AC. Here's Why I Turned Around Before Leaving the Block
Sony's Reon Pocket Pro Plus delivered on its promise of keeping me cool—but one major flaw made wearing it in public surprisingly difficult.
PENN Entertainment Sheds Indiana Bid to Boost Income Tax Base
Penn Entertainment Inc. convinced the Indiana Supreme Court to allow the casino operator to exclude unapportioned wagering taxes it paid to other states from its in-state income tax base.
Milwaukee Brewers' Joey Ortiz Delivers Heroics in Late Innings
Facing roster pressure after a top prospect's arrival, the infielder silenced critics with a clutch eighth-inning blast to secure a vital victory and solidify his place with the Milwaukee Brewers.
Reaching communities close to hostilities in Ukraine
Primary health care teams in Ukraine are reaching 121 locations within 60 km from active hostilities. This is part of the largest primary health care intervention in frontline areas in the country. European Union (EU)-supported teams are delivering essential services to people trapped by constant shelling and severe security constraints in 7 regions where no pharmacies operate, no health facilities function and evacuation remains impossible for residents.
Inside the SpaceX trading frenzy
SpaceX was expected to be one of the hottest stocks on Wall Street this year – and it has quickly delivered on that promise, shattering trading volume records while companies race to launch new products tied to the stock.
Scientists cured sickle cell. Then their next challenge began.
Gene editing has delivered remarkable results against sickle cell disease. Now researchers are working to make these personalized treatments faster, cheaper, and available to far more patients.
Alt-rock band Drip Edges hits the stage at Gabe’s
Drip Edges, led by Jeremy Scott, delivers powerful alt-rock influenced by power pop bands like Sugar and the Smithereens, showcasing catchy, dynamic tracks that highlight the lead singer’s dedication to
[8-K] ALLIANCE ENTERTAINMENT HOLDING CORP Reports Material Event
Alliance Entertainment Holding Corporation reports that majority stockholders delivered a written consent on June 24, 2026 approving a major charter change.
"It's not gonna be good:' Local business braces for Parkway East closure
Dave Guerin, a Swissvale business owner, shared his concerns about the upcoming 25-day Parkway East closure, citing challenges for deliveries and suppliers navigating detours.
A Longstanding Theory of Childbirth Is a Myth
Delivering a human baby is not uniquely difficult.
Healthcare AI's next big leap: Removing friction from clinical workflows
Rather than just adding more applications, one CMIO says, organizations should focus on using automation and intelligence to eliminate unnecessary steps, reduce clinician burden and streamline care delivery.
Google Pixel phones may soon let you ‘shuffle’ your favorite wallpapers
According to new findings under the hood of Google’s software, future Pixel updates may deliver support for a “shuffle” option...
Austin Home Theater Helps Central Texas Homeowners Reimagine Entertainment With Custom Home Theater Design
Locally owned integrator combines decades of experience with personalized design to deliver cinema-quality systems across the Austin area
Jared Moskowitz opens 32-point lead in CD 25 Democratic Primary
A new Beacon Insights survey puts him past 50%, more than doubling Oliver Larkin.
Science and Technology Must Deliver for the Public
The United States has never lacked for scientific ambition. What we need now is a renewed civic commitment to ensuring that talent is harnessed for the benefit of all people. Science can work for everyone. Join us as we build a broader coalition committed to that vision.
Liver health is the latest wellness obsession
Interest in liver health and sales of liver-focused supplements is soaring as people become more aware of the organ's role in overall health, and rates of liver disease rise.
Remembering Joe Delaney, 43 years after he died
24-year-old running back gave his life to try to save three children.
Liverpool transfer news: Bradley Barcola among alternative targets with PSG in talks to sign Yan Diomande
Liverpool target Yan Diomande has indicated his desire to join Paris Saint-Germain; PSG winger Bradley Barcola features highly among options Reds are considering as an alternative; Barcolas PSG future is uncertain due to frustrations about being overlooked for selection in big games
Dario Announces Strategic Collaboration with Beluga Health to Deliver Provider-Backed, Integrated Care at Scale
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in AI-powered digital health solutions, today announced it...
Dario Announces Strategic Collaboration with Beluga Health to Deliver Provider-Backed, Integrated Care at Scale
/PRNewswire/ -- DarioHealth Corp. (NASDAQ: DRIO) (the "Company", "DarioHealth" or "Dario"), a leader in AI-powered digital health solutions, today announced it...
PPDS Brings 'Limitless' TV Entertainment To Historic 5 Star Bellevue Syrene Hotel With Philips MediaSuite
PPDS, the exclusive global provider of Philips Professional Displays, has announced that its Philips MediaSuite TV range has been chosen to deliver seamless access to a virtually limitless world of | Delivering modern luxuries to the 18th century hotel in Sorrento, Philips MediaSuite TVs with cast built in are now bringing seamless access to millions of movies, TV shows, games, and streaming apps to guests at one of Italy's most prestigious and exquisite hospitality destinations.
ACE WFM Strengthens Workforce System Delivery Approach for Australian Organisations
Melbourne, AUSTRALIA, June 29, 2026 (GLOBE NEWSWIRE) -- ACE WFM, a workforce management consulting provider, has outlined its structured approac...
John Oliver scores his dream job: A soap opera gig on 'General Hospital'
The host of HBO's "Last Week Tonight" will realize one of his big wishes in July with a guest spot on the ABC soap opera "General Hospital."
Millions take omega-3 fish oil for brain health but a new study found no benefit
Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.
Millions take omega-3 fish oil for brain health but a new study found no benefit
Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.
Meaningful Outcomes Determine the Winners of the Health AI Race
Global investment in healthcare AI exceeded $18 billion in 2025, yet health systems still lack a shared understanding of the outcomes that investment should deliver. This paper argues that success in the health AI race will be determined not by technological sophistication but by which systems first identify and pursue the outcomes that matter most to patients, professionals and health systems. Without a shared language for defining and measuring what healthcare AI should deliver, systems risk optimizing for what is easiest to count rather than what matters most. This paper provides a framework for ensuring AI investment translates into real value for healthcare systems and the populations they serve.
49ers Insider Delivers Commanders Blunt Reality on Brandon Aiyuk
The Washington Commanders are a side character in the rift between Brandon Aiyuk and the San Francisco 49ers. In recent days, Aiyuk has made it clear that he wants to play for the Commanders.Before the remarks from Aiyuk, there was only reporting of Washington’s interest in the 49ers’ wideout. Nonetheless, that’s slightly changed with the […] The post 49ers Insider Delivers Commanders Blunt Reality on Brandon Aiyuk appeared first on HEAVY.
Health insurers are looking for MAHA wins
The companies are offering benefits aimed at appealing to Robert F. Kennedy Jr. and his Make America Healthy Again movement.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Lille reveal Ayyoub Bouaddi stance amid Liverpool interest
Liverpool Face Patient Lille Stance Over Ayyoub Bouaddi TransferLiverpool’s interest in Ayyoub Bouaddi has moved into sharper focus, with AS reporting that Lille are prepared to take a patient appro...
Toronto Blue Jays Infielder Delivers Simple Message to Fans
Ernie Clement was named an All-Star Game starter earlier this week.
From global politics to legendary performances: 110 years of Western Herald
June 28, 2026 marks the 110th birthday of Western Herald, celebrating over a century of journalism and dedication to delivering news to campus.
World Cup Watch: Red Representation High in Knockouts
Liverpool will be well-represented in the Round of 32 at the World Cup.
Belkin launches new 14-in-1 Thunderbolt 5 dock with 140W charging and triple 4K display support
Belkin has launched a 14-in-1 Thunderbolt 5 Dock in China priced at 2,299 yuan (approximately $338). The Belkin dock ships with a 180W adapter and 1m cable and delivers 140W USB Power Delivery over a single Thunderbolt 5 connection, with bandwidth scaling from 80Gbps to 120Gbps for high-resolution display use. Belkin briefly listed the dock on its global website at $350 before removing the page, hinting at a global launch.
Texas A&M’s Marcel Reed impresses in Air‑It‑Out exhibition
Marcel Reed delivered one of the top highlights at the Manning Passing Academy, dropping a perfect deep ball during the Air‑It‑Out exhibition.
Why soccer is life - Live Updates
“Sport is never just about sport. It is about storytelling and national storytelling,” says acclaimed playwright.
The weekend of Andy Burnham’s life - Live Updates
If England wins the World Cup, one pollster says the new prime minister should call a snap election.
HISTORY IN THE MAKING: A RECORD-BREAKING OPENING DAY AT THE PAN AMERICAN ATHLETICS CHAMPIONSHIP MEDELLÍN 2026
The Pan American Athletics Championship delivered everything the Americas had been waiting […]
Which coach helped Dianna Russini get out of a ticket?
The recent New York Times article regarding former New York Times reporter Dianna Russini answered some lingering questions.
New vitamin B12 therapy shows promise against deadly brain cancer
Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.
Walker Buehler delivers statement win for the Padres over Dodgers
The Sporting Tribune's Fernando Ramirez writes about Walker Buehler throwing a solid game against his former team.
Twin Cities Pride organizers expect festival to deliver big boost to businesses
Trump-backed Letlow faces Fleming in Louisiana GOP Senate runoff
President Donald Trump’s choice for U.S. Senate in Louisiana is seeking to secure the GOP nomination and deliver another win for the president in his effort to replace Republicans who crossed him
Why Belgium’s prime minister isn’t cheering on the Red Devils - Live Updates
The World Cup isn’t easy for Bart De Wever.
Seattle World Cup match brings fans, Pride weekend, and global politics together
The World Cup’s stop in Seattle has already delivered packed streets, record-setting business days and a surge of international energy around Lumen Field.
Healthcare AI Leaders Are Rapidly Trying To Outmaneuver Skyrocketing Memory And GPU Costs
Compute power has become one of the most crucial components of the healthcare delivery cycle.
The 5-Question Org Chart Audit I Run Before Scaling AI Across a Business
AI success depends less on the technology and more on the organization behind it. These five questions help leaders identify the structural barriers that prevent AI from delivering real business impact.
Hisense U7SG 4K TV: Modern Entertainment for the New Age
The Hisense U7SG 4K TV delivers stunning MiniLED visuals, 165Hz gaming performance, and Dolby Vision IQ for an immersive entertainment experience.
New feed trailer expands feed delivery opportunities
Delivery of bulk feed produced at the Iowa State University Kent Feed Mill and Grain Science Complex to Iowa State’s animal science farms is now possible, thanks to a new high-tech feed trailer.
Morocco jails 29, including politicians and sports figures, in drug trial
Casablanca court delivers landmark verdict in 'Escobar of the Sahara' case: up to 12 years for top figures.
ECU Health announces 2026 Board Quality Leadership Award winners
ECU Health Board Quality Leadership Award winners were recognized for delivering exceptional experiences and advancing patient outcomes.
Council Explores AI, Quality Improvement and Patient Safety to Advance Community Health
The MHA Council on Health Access and Community Impact held its final meeting of the program year June 4 to examine emerging opportunities and challenges shaping healthcare delivery and advancing community health.
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
What Happens to Your Liver When You Drink Green Tea Every Day
What does green tea do for your liver? Learn how it may affect fat buildup, inflammation, and liver enzymes, plus risks and benefits.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Medical breakthroughs collide with the health system
The buzziest advances — like personalized gene therapies or AI-discovered drugs — may not deliver.
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Takeaways: Supreme Court hands Trump massive wins on immigration agenda
The Supreme Court’s conservative majority delivered President Donald Trump a pair of significant affirmations of his immigration policy Thursday, paving the way for the administration to effectively remove more than 1 million people from the US and keep many others from entering in the first place.
http://democrats-energycommerce.house.gov/media/press-releases/pallone-opening-remarks-health-subcommittee-markup-15-bills
Energy and Commerce Committee Ranking Member Frank Pallone, Jr. (D-NJ) delivered the following opening remarks today at a Health Subcommittee markup of 15 bills:
Gov. Shapiro on Mamdani-backed wins in NYC: Candidates doing ‘performative politics’ must learn ‘how to deliver results’
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
Supreme Court sides with big business in Roundup cancer risk fight
The ruling is also a victory for the Trump administration and a defeat for the Make America Healthy Again movement.
'This is the next jump in technology': World's first sub-1nm chip keeps Moore's Law alive a little longer
IBM's NanoStack architecture has helped scientists cram 100 billion transistors onto a computer chip, delivering 50% better performance and consuming 70% less energy than the current generation.
AI for Small Business: The Quick-Win Approach
Voice of Business Blog Guest post from Greater Rochester Chamber member IT Insights of Rochester In 2025, 58% of small businesses report using generative AI tools, up from 40% in 2024 and 23% in 2023, according to the U.S. Chamber of Commerce. Adoption has grown quickly in just a few years and is now delivering…
Regenerative Agriculture and Population Health
Regenerative agriculture can enhance food quality and reduce harmful exposures through improved soil biology, biodiversity, and ecosystem health, yielding downstream benefits for agriculture, food systems, and human health. It may improve profitability through greater land resilience and lower input costs and may deliver benefits to farms, farmers, communities, and the broader environment. More research is warranted to understand the full range of potential health benefits of regenerative agriculture.
FDA-approved drug may finally help immunotherapy defeat rare liver cancer
Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.
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Prosus Investment Values Health Insurer Alan at $6.3 Billion
Prosus—the largest shareholder in Tencent Holdings and owner of food-delivery company Just Eat Takeaway—is investing €400 million in Alan.
Tamworth sign duo Dyson and Bailey
National League side Tamworth sign midfielder Oliver Dyson and left-back Joshua Bailey.
Liverpool signs find a way to support business
EAST LIVERPOOL-As part of the revitalization process for the historic downtown area in East Liverpool, two wayfinding signs have just been installed in the downtown area to help direct people walking through downtown to businesses located in the area. The wayfinding signs, which have smaller directional signs on them pointing out the locations of multiple […]
Reese Witherspoon's boyfriend makes red carpet debut at 'Elle' premiere
Reese Witherspoon and her financier beau, Oliver Haarmann, have set a new bar in their relationship.
WATCH: Under proposed rule, USPS won't deliver mail ballots to states that don't provide voter rolls, postmaster general says
Postmaster General David Steiner told a Senate committee Wednesday that, if a proposed rule is adopted, the U.S. Postal Service would withhold mail ballots from states that do not hand over to the federal government lists of people who have requested absentee or mail ballots.
Healthcare Providers Look Beyond Price To Deliver Better Value
A new approach to procurement promises to not just produce much-needed cost savings but also improve outcomes for patients.
Reese Witherspoon makes first public appearance with boyfriend Oliver Haarmann
Reese Witherspoon made her first public appearance with financier boyfriend Oliver Haarmann at the 'Elle' premiere in New York City.
California workers' compensation bill opposed by NFLPA has been pulled
A bill that would have revamped workers' compensation laws in California to the detriment of professional athletes has died.
Sony Pictures Invests in Cosm Dome Venues in Major Deal
Cosm venues feature a unique dome shape, delivering a fresh experience for live events and theatrical screenings.
Sony Pictures Invests in Cosm Dome Venues in Major Deal
Cosm venues feature a unique dome shape, delivering a fresh experience for live events and theatrical screenings.
Bears are working on a bill for an Illinois stadium
Indiana keeps waiting for something that may never happen.
Science Day 2026 at the HLPF: The science-policy imperative in the final stretch to 2030 and beyond
Science Day convenes scientists, policymakers and societal actors at the HLPF to examine science's role in accelerating SDG delivery to 2030.
FSU computational scientist helps advance targeted drug-delivery systems using coding, modeling
A Florida State University computational scientist is paving the way for future medical breakthroughs by developing mathematical models and simulations to
Men’s Health: Caring for the Body, Mind and Spirit
FORT POLK, La. — Seeking help is often viewed as a vulnerability in military culture, but healthcare providers at Bayne-Jones Army Community Hospital are reframing it as a tactical strength. In observance of Men's Health Month, a BJACH family physician, a mental health provider and the hospital chaplain have partnered to deliver a unified message: peak military readiness requires actively maintaining the body, mind and spirit. From utilizing routine screenings to leveraging physical discipline to build mental resilience and cultivating a strong spiritual community, the team outlines actionable steps to overcome the physical, emotional and isolation barriers that uniquely impact men.
Rejuvenating politics and delivering on promises of equality and participation: milestone event in Strasbourg
Young people are shaping the New Democratic Pact for Europe
How New Hampshire Motor Speedway Delivers Maximum Entertainment for the Price
New Hampshire Motor Speedway delivers more than just races — it's an immersive NASCAR weekend featuring multiple race series, live music, fan events and unforgettable atmosphere. Perfect for fans wanting excitement and great value, NHMS provides an action-packed experience that brings motorsports to life at "The Magic Mile."
Pro-Israel politics just took a huge hit in New York
Progressives critical of Israel swept a trio of House races in the home of the nation’s largest Jewish population — a stunning shift that carries national implications for the party.
Cait Conley wins Democratic primary to face Rep. Mike Lawler
The Army vet will now try to oust the Republican incumbent in a district that favored Kamala Harris in 2024.
Don Toliver expands world tour with first stop at Sacramento’s Golden 1 Center
The ‘Octane’ World Tour’s ‘Nitrous’ expansion will kick off at Sacramento’s Golden 1 Center.
2026 World Cup Odds: Back Offensive Display In Canada-Switzerland
Will Hill delivers his best bet for Wednesday's pivotal Group B showdown between Canada and Switzerland.
DOJ announces $6.5B healthcare fraud takedown with record Medicaid enforcement
The Department of Justice unveiled charges against 455 people, including 90 doctors and other licensed medical professionals, for their alleged participation in healthcare schemes that involved mor | Law enforcement unveiled charges against 455 defendants for their alleged participation in healthcare schemes, among which fraudulent amniotic wound allografts and undelivered Medicaid services were spotlighted.
The NFL draws a line in the sand with Brendan Sorsby, delivering a scathing lesson in accountability
FedEx posts strong earnings results in last quarter with freight business
FedEx posted strong fiscal fourth quarter earnings on Tuesday in the company's last quarter that included the freight business before its spin-off.
Regions Bank Announces New Leaders in Key Markets to Drive Business Growth and Customer Experience
Lisa Phillips to lead Consumer Banking in Georgia and the Carolinas; Mia Hubbard to serve as Retail Service Delivery Manager for the entire Regions branch network. Regions Bank on Tuesday announced two key leadership appointments that will drive continued business growth in vibrant Southeastern markets while also supporting consistent service enhancements at branches throughout the company’s 15-state retail banking footprint. Longtime Regions banker Mia Hubbard (top left) will serve as Retail Service Delivery Manager, and Lisa Phillips (lower, right) will succeed Hubbard as Consumer Banking Executive for Regions in Georgia and the Carolinas. Lisa Phillips will serve as Consumer Banking Executive for Georgia and the Carolinas, overseeing branch performance and growth in vital and fast-growing markets such as Atlanta, Charlotte, and additional cities across the three states. Phillips succeeds Mia Hubbard , who is taking on the role of leading Service Delivery across Regions’ entire
Most innovative CMOs of 2026: power list
Business Insider's list of the most innovative CMOs spotlights marketers who are pushing brands into new territory and delivering measurable results.
Why the forces that felled Keir Starmer threaten so many western leaders
British Prime Minister Keir Starmer was felled by a curse haunting most western leaders — a failure to deliver change to voters who’ve lost trust in the capacity of modern politics to make their lives better and more affordable.
Silicon Valley spent big in California's primary election. Did tech money influence the results?
California's June primary delivered a mixed verdict on Silicon Valley's growing political influence.
Can Canadian Organizations Deliver in the Next Era of Business AI? IBM Finds Many May Not Be Ready
As Canadian CEOs accelerate AI adoption to drive productivity and growth, C-suite leaders across Canada warn that governance, oversight and workforce readiness are struggling to keep pace, creating a widening 'control gap.'
Apple Approves Production of OLED Panels for Foldable iPhone
Samsung Display has received Apple's approval to begin module production of OLED panels for Apple's first foldable iPhone, according to a report today from TheElec. Citing industry sources, the report says Samsung Display has started operating part of its back-end production lines in Vietnam to fulfill an initial order of around three million panels scheduled for delivery this year.
WMO Executive Council seeks to balance growing demands for science and services
“The demand for what WMO delivers and what National Meteorological and Hydrological Services produce - weather forecasts and warnings, climate data and standards and for scientific cooperation - is growing. Every extreme event makes that clearer,” WMO Secretary-General Celeste Saulo told the opening session.