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One of Earth’s most explosive supervolcanoes is recharging
Far beneath the ocean near Japan, scientists have discovered that the magma system linked to the most powerful eruption of the Holocene is slowly rebuilding. By using seismic imaging, researchers mapped a large magma reservoir under the Kikai caldera and confirmed it is the same system that fueled the massive eruption 7,300 years ago. However, the magma now present is newly injected, not leftover, as shown by changes in the chemistry of recent volcanic material and the growth of a lava dome over thousands of years.
Business groups warn Maine data privacy proposal could raise marketing costs, hurt growth
The Maine State Chamber of Commerce is urging CEOs and senior executives across the state to join its opposition.
Central Texas College students explore the science of Cultivation
KILLEEN, Texas (FOX 44) – Temperatures are on the rise and the first signs of spring are starting to bring new growth and color to the landscape as students at Central Texas College begin lea…
Central Texas College students explore the science of Cultivation
KILLEEN, Texas (FOX 44) – Temperatures are on the rise and the first signs of spring are starting to bring new growth and color to the landscape as students at Central Texas College begin learning fir...
NWA primed for next phase of regional growth - Talk Business & Politics
Like many Northwest Arkansas natives, I’ve been amazed to watch our region evolve from a quiet landscape of pastures into a thriving metropolitan hub. With our population expected to grow...
NWA primed for next phase of regional growth - Talk Business & Politics
Like many Northwest Arkansas natives, I’ve been amazed to watch our region evolve from a quiet landscape of pastures into a thriving metropolitan hub. With our population expected to grow...
Women's professional sports see massive growth as fans pack stadiums and viewership hits record highs
Professional women's sports are experiencing hypergrowth, expanding 4.5 times faster than men's sports.
Company in CT for 100 years buys well-known transportation business. It means new ‘local jobs’: owner
It means investment in workforce development, fleet modernization, and regional economic growth, the company said.
Scientists discover a hidden system that turns brown fat into a calorie burner
Scientists have identified a key biological system that helps brown fat burn energy by building the networks it needs to function. A protein called SLIT3 splits into two parts, with each piece guiding the growth of blood vessels and nerves inside brown fat. These structures allow the tissue to pull in nutrients and rapidly convert them into heat instead of storing them as fat.
Impossible Science Live! with World Champion of Magic Jason Latimer
Impossible Science Live! with World Champion of Magic Jason Latimer From bending light with physics, to shaping water with chemistry and walking through solid glass with engineering, World Champion of Magic Jason Latimer’s mind-blowing live show delivers an inspiring message of how “The right question changes everything.” Impossible Science LIVE! expands on Jason Latimer’s inspiring TED Talk “ Seeing Beyond the Illusion of Knowledge ” with family-friendly, mind-blowing illusion entertainment. Uniting his favorite illusions from his illustrious career, Latimer reveals the secret to his magic is not special powers but simply a pursuit of challenging the impossible with curiosity. During your museum visit from April 7-11, 2026, drop into the auditorium for one of Latimer’s shows throughout the day. Shows are included with your Spring Break admission and FREE for museum members. Add a membership to your cart for free Spring Break admission! Available showtimes: 10:30 a.m., 11:30 a.m., 1 p.m., 2 p.m. daily, with a 3:30 p.m. show on Saturday, April 11. Open seating; first come, first seated. About Jason Latimer: Jason Latimer has been featured on television around the world as both a scientist and magician. While Latimer is both a curator of the iconic Fleet Museum in San Diego, CA, and a World Champion Magician his network specials, TV series, and appearances span the globe. Jason has been featured as a science host on the Science Channel, Roku, Amazon, and as a magician on the Syfy Channel, History, BBC ONE, and Japan’s NHK. In 2021, SONY partnered with Latimer to bring his unique blend of science and magic to online and to PBS to assist with distance learning. Impossible Science’s growth has been exponential ever since, garnering over a hundred million views and multiple streaming awards as an educational series.
Business Lookahead: Gauging the war's impact
STORY: From a worrying drop in stocks to a surge in energy prices from the war in the Middle East to key data on jobs and trade, these are the stories to watch in business and finance in the coming week. ::Look Ahead::War impactThe first quarter is ending with financial markets at the mercy of geopolitics.The Iran war has wiped roughly $7 trillion off global stocks since it erupted.With oil prices up nearly 70% year to date, suddenly interest rates are heading up, rather than down, and energy-hungry AI does not look like such a slam-dunk anymore.Meanwhile, gold has plunged 16% after being nearly unstoppable since the start of 2025.We’ll see whether markets roll on or rollover as the second quarter begins.::Job growth in focusThe U.S. jobs report for March comes out Friday.It will offer a crucial view into the economy's health as investors gauge fallout from the energy price surge.Monthly payrolls are seen rising by 48,000, according to a Reuters poll. February's surprisingly weak report caught Wall Street off guard, showing nonfarm payrolls fell by 92,000 while the unemployment rate increased to 4.4%.Uncertainty over the Iran war is also clouding the economic forecasts for the Federal Reserve, with Wall Street pulling back on expectations for U.S. interest rate cuts this year as the oil price surge fuels concerns about rising inflation.Other U.S. data in the coming week includes retail sales for February and reports on manufacturing and services activity.::Chip checkSouth Korea releases its trade data for March on Wednesday.It will provide an early indicator of how the global economy is holding up in the face of the war and the resulting shock to energy prices. Korea's export-heavy economy is a bellwether for global trade and one of the first to report data from the previous month.Its manufacturing fortunes are of even greater interest than usual, not just because of its dependence on Middle Eastern energy imports, but also because its world-leading DRAM chips are of critical importance to the AI sector and currently in short supply too. ::Inflation assessmentAnd flash euro zone inflation for March is due on Tuesday. After long hovering around the 2% mark, higher energy prices are now expected to push headline inflation up, as they did in 2022. The question is, how large and sustained any jump in inflation might be.Early data is not painting a pretty picture. Private sector growth in the euro zone slowed sharply in March, with input costs rising to their highest in more than three years and supply chains being significantly disrupted.Money markets are now heavily pricing in a rate hike which was almost unthinkable before the Iran war.
Time capsule buried in 2010 opened in Laredo
A time capsule buried by the Latin American International Sports Hall of Fame was opened in Laredo, highlighting community history, personal stories and the city’s growth.
UMD Smith Center for AI in Business Awarded $1M+ Federal Grant to Help Small Businesses Adopt AI
The University of Maryland’s business school has received $1.031 million in federal funding to help Maryland small businesses adopt AI, offering tools, training and research to improve efficiency, expand access and support economic growth statewide.
'Growth' for Republic of Ireland despite Prague pain
Republic of Ireland boss Heimir Hallgrimsson says there are plenty of reasons to be optimistic following his side's World Cup play-off shootout defeat by the Czech Republic.
Preserving Detroit History: City awards grants to 30 long-standing local businesses
On Thursday evening, 30 Detroit legacy businesses were awarded a grant by the Detroit Economic Growth Corporation and the mayor's office.
Texas A&M softball HC Trisha Ford previews the Texas series
Trisha Ford previews A&M’s trip to No. 1 Texas, stressing growth, lineup clarity, and embracing the rivalry’s trademark “spice.”
Unity Releases Preliminary First Quarter Results Exceeding Guidance; Will Enhance Growth and Profitability by Exiting Non-Strategic Ad Businesses
Unity (NYSE: U), the world’s leading game engine, today announced preliminary revenue and Adjusted EBITDA for the first quarter 2026 above guidance. Unity ex...
Roseman University launches life science incubator to promote discoveries
Roseman University is launching a new life science incubator to support the growth of the biotechnology sector in Southern Nevada.
Analyst says Epic Games layoffs send a clear signal
The myth of perpetual growth continues to bulldoze through the industry.
Eastern University Launches 100-Percent-Online Master’s in AI Business Strategy
Eastern has launched an online Master of Science in AI Business Strategy to equip leaders with the skills to harness AI for strategic growth.
The fastest-growing and fastest-shrinking US cities
New Census Bureau data showed which cities experienced population growth from July 2024 to July 2025. Several Southern metros grew the fastest.
Wall Street pros are nervous about Iran and warn about complacency
A prolonged conflict could hit growth, lift inflation, and jolt equities.
Hendrix College President Karen Petersen named Business Executive of the Year by Conway Area Chamber of Commerce
March 25, 2026 – The Conway Area Chamber of Commerce has named Hendrix College President Dr. Karen Petersen as its Business Executive of the Year. The prestigious award recognizes leadership that drives institutional excellence while fostering significant economic and community growth within the region.
Wasatch County launches $90,000 small business microgrant program
The microgrant offers a 50/50 matching reimbursement of up to $5,000 for eligible projects that support business growth.
Brenmiller Energy Issues Business Update Highlighting Commercial Breakthrough, First TES Revenue and BNRG360 Growth Strategy
Delivered flagship Tempo project, Brenmiller's first commercial-scale boiler replacement deployment, marking a major operational milestone in the Company's transition toward commercializationRecognized first revenue from a TES system sale, validating Brenmiller's ability to convert project execution into reported revenueEntering 2026 with previously disclosed projected 2026 revenue of approximately $1.7 million tied to Tempo execution milestones, which management believes reflects the beginning.
JPMorgan’s Jamie Dimon says remote work breeds ‘rope-a-dope politics’ and stunts young workers’ growth
Dimon has a message for remote workers: the customer comes first.
EQB welcomes Daniel Rethazy as EVP, Personal Banking, adding top banking talent to reignite core business growth and execute on transformation
EQB Inc. (TSX: EQB) today announces Daniel Rethazy's appointment as Executive Vice President, Personal Banking. Mr. Rethazy brings deep experience in Canadian Banking to EQB that will accelerate momentum and unlock a new era of growth for the company's Personal Banking franchise, delivering a more competitive and rewarding banking experience, and a stronger and more resilient banking industry for all Canadians.
Growing Southern Nevada’s health care economy
Last week The Lincy Institute, the Vegas Chamber, the Vegas Chamber Leadership Foundation, and the Nevada Health and Bioscience Corporation hosted a symposium on the future of Southern Nevada’s health care economy. Today, health care is the fastest-growing sector in the regional economy having added more than 42,000 jobs since 2016. Yet, despite this growth […]
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth
Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to
Inter Miami CF Announces Heron Sports & Entertainment as Club Continues Unprecedented Growth
Heron S&E to serve as promoter of major entertainment events both locally at their new home at Miami Freedom Park, Inter Miami CF Stadium in Fort Lauderdale, the Florida Blue Training Center, and globally Continuing to push the boundaries in the global entertainment landscape, Inter Miami CF is excited to
Cardinal Health (CAH) Emerged as a Key Contributor on Pharmaceutical Strength and Margin Expansion
Renaissance Investment Management, an investment management company, released its Q4 2025 “Large Cap Growth Strategy” investor letter. A copy of the letter can be downloaded here. The strategy faced a difficult fourth quarter of 2025, underperforming both the S&P 500, which gained 2.7%, and the Russell 1000 Growth Index as market leadership remained concentrated in […]
Obelisk Infotech Launches AI-Driven SEO Automation to Help Businesses Scale Digital Growth
PUNJAB, INDIA / ACCESS Newswire / March 25, 2026 / As more businesses move online and competition across digital channels continues to grow, the need for smarter and more scalable marketing strategies has become increasingly important. Obelisk Infotech, ...
Deloitte: From Subscribers to Superfans: Fan Engagement Shapes the Next Phase of Media and Entertainment Growth
/PRNewswire/ -- Key takeaways Consumer spend remains flat on streaming services: The average subscribing household reports spending $69 per month on streaming...
Italy's growth outlook darkens due to Iran conflict, business lobby says
Italy's economy will grow by 0.5% this year, the country's main business lobby Confindustria forecast on Wednesday, cutting its previous 0.7% estimate made in October and warning of strong downside risks if the conflict in Iran drags on.
Political Science Program Encounters Growth in Enrollment
The department chair received numbers indicating political science as a major is on the rise.
At Baklava Bakery & Coffee, a family business evolves with a new generation
One year after opening, the Arlington cafe extends a 20-year bakery operation while sons help shape its coffee program for future growth.
Health Ring Oura Interviews Banks for IPO as Soon as This Year
Health ring Oura has been interviewing bankers to advise on an initial public offering that could take place as soon as this year, according to a person with direct knowledge of discussions. A public offering would follow fast growth at the company, which sells connected devices—which cost from ...
Blaise Ingoglia targets Citrus County for 'wasteful' spending
'That’s an amazing amount of government growth in six years.'
US business activity slows as war-driven costs surge
U.S. business activity slowed in March to its weakest pace in nearly a year as rising costs tied to the Iran conflict weighed on demand, Bloomberg writes. A key S&P Global index dipped but remained in expansion territory, while input prices surged to multimonth highs. Service sector growth softened, hiring declined and companies passed higher […]
Blog explains why context matters in discussions on health care spending
An AHA blog published March 24 responds to a recent KFF brief on the role of hospital care in recent health care spending growth.
U.S. Business Activity Hits 11-Month Low as War Drives Prices Higher
U.S. business activity growth slowed to an 11-month low in March while prices surged, according to a preliminary S&P Global survey released Tuesday. S&P’s composite output index, based on its surveys of services and manufacturing firms, fell to 51.4 from 51.9 in February. That was its weakest readi
US Business Activity Growth Cools as Prices Rise on Iran War
Growth in US business activity slowed in March to an almost one-year low and prices paid for materials and other inputs picked up in the wake of the US-Israel war with Iran.
Tesla Book Covers Business Principles
McNeill’s book outlines Musk-inspired principles: question rules, simplify processes, optimize systems, automate last, and accelerate growth.
Designing Growth That Feels Seamless for Customers
We’ve redesigned our U.S. Licensed Coffeehouse Business, and we’re now positioned to grow with greater focus in the places where customers already are.
Pro Padel League raises $15 million as investors bet on sport’s U.S. growth
The Pro Padel League has raised $15 million in new funding as it looks to accelerate its next phase of growth in the U.S.
Pound loses footing, business activity growth slows on Iran war hit
The British pound fell against the dollar on Tuesday, reversing some of its rise from the day before, as the Middle East war continues to hold sway over markets and as signs emerged that the conflict was starting to affect Britain's economy.
F1 CEO talks US growth as business accelerates
Formula One (F1) CEO Stefano Domenicali joins Yahoo Finance Executive Editor Brian Sozzi to discuss F1's rapid growth in the US market, new racing regulations, and more. Watch the video above to hear more on the sport's focus on expansion and entertainment.
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
Stock markets rocked by Trump’s Iran ultimatum, as UK economy faces growth hit
Rolling coverage of the latest economic and financial news
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Business investment in the era of digital transformation
The weak performance of business investment across the OECD since the Global Financial Crisis holds back potential growth. However, it masks a strong investment dynamic in digital assets such as hardware, software, and databases. This column describes how this divergence between digital and non-digital assets has intensified from the mid-2010s. The strong investment performance of the US relative to the rest of the OECD is almost exclusively a digital phenomenon. A ‘digital divide’ is emerging, where laggard countries are accumulating digital capital per worker more slowly than those with higher initial starting levels.
Small business and entrepreneurship growth a point of focus for Secretary of State’s Office
LEWISBURG, WV (WVNS) – Entrepreneurs and small business owners in the Mountain State have gotten some extra support with the passage of new legislation. West Virginia Secretary of State Kris Warner me...
Prairieville’s Sarah Taylor is scaling a health network for industrial growth
As Ascension Parish’s industrial boom continues to draw contractors and skilled workers to the region, the demand for occupational health services is rising alongside it. NuREADY Health Network is expanding its footprint across the Gulf South to help companies manage workforce testing, injury care and compliance across multiple job sites. Major industrial construction and maintenance […]
Unilever in talks to sell food business to smaller rival McCormick
Unilever, which owns Hellmann's mayonnaise and Knorr stock cubes, seeks to focus on higher-growth businesses.
Hispanic Women-Owned Business Growth—Revenue Hasn’t Caught Up
Hispanic/Latina women are launching businesses at record rates and leading in employer firm growth. New IWOB data shows why revenue still doesn’t match the momentum—and what changes that.
Credit Acceptance Appoints Steffen Schumann as Chief Business Officer
New Role Strengthens Enterprise Business Planning, Pricing Strategy, and Performance Management to Support Disciplined GrowthSouthfield, Michigan, March 19, 2026 (GLOBE NEWSWIRE) -- Credit Acceptance Corporation (Nasdaq: CACC) (referred to as the “Company”, “Credit Acceptance”, “we”, “our”, or “us”) today announced that Steffen Schumann has joined the Company as Chief Business Officer, reporting to Chief Executive Officer Vinayak Hegde. In this newly created role, Schumann will help drive growth
Be counted among the Capital Region’s top private companies
Each year, Business Report ranks the Top 100 Private Companies in the Capital Region — one of our most anticipated and widely read features. It’s the definitive look at the companies driving growth, investment and job creation across our market. If your company is privately held and headquartered in the Capital Region, we want to […]
NEW DATA: Florida Small Business Owners Confident About Future Growth
Sunshine State remains a top state for small business success
Dan Nelms
I realized Stanford GSB could help round out my skill set and prepare me to be an executive for a growth startup.
What Business Leaders Can Learn From A Symphony Orchestra
How Montreal Symphony Orchestra leaders balance artistic excellence and business strategy, offering lessons in leadership, innovation and audience growth.
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
SAN FRANCISCO, March 19, 2026--Nextdoor Holdings, Inc. (NYSE: NXDR), the essential neighborhood network, today announced the promotion of Tony Castellanos to Executive Vice President, People. Castellanos will lead Nextdoor's People organization — including talent acquisition, compensation, HR business partnering, and benefits — as the company deepens its investment in AI-enabled People operations and continues to scale its workforce strategy.
Pikl Pioneers a New Category of Insurance-Enabled Business Models, Earning it 20% UK Short-Term Rental Market Share
Pikl, the company pioneering insurance-enabled business models that drive revenue whilst protecting against downside risk, today announced that it has achieved 20% market share in the UK short-term rental market – the first industry in which its insurance-enabled growth solutions have been delivered. The achievement comes just two years after Pikl launched its flagship flexible cancellation solution in 2024, which allows property management companies (PMCs) to offer guests the flexible booking o
SK pharmteco Reaffirms Three-Business-Unit Strategy, Strengthens Global Gene Therapy Business Unit with Funding Commitment
RANCHO CORDOVA, Calif., March 19, 2026 (GLOBE NEWSWIRE) -- SK pharmteco today announced a significant funding commitment to support strategic initiatives within its viral vector business, while reaffirming its long-term growth strategy across three business units: small molecule, peptides, and viral vectors. SK pharmteco is sharpening its strategy to provide pharmaceutical and biotechnology partners with the financial strength, technical rigor, and operational infrastructure needed for long-term
NN, Inc. Provides Update on Business Growth in the Data Center, AI Reasoning, and Cloud Computing Markets
CHARLOTTE, N.C., March 18, 2026 (GLOBE NEWSWIRE) -- NN, Inc. (“NN” or the “Company”) (NASDAQ: NNBR), a global diversified industrial company that engineers and manufactures high-precision components and assemblies with six sigma quality, today provided an update on its growing presence in the data center market, a key targeted growth market for the Company. NN has secured multiple new awards with a leading global provider of AI infrastructure and data center computing equipment. As this industry
Georgiana mayor proclaims SBDC day highlighting the center's impact on business growth in Butler County
The City of Georgiana joined communities across the nation in celebrating National SBDC Day on March 18, as Mayor Ninna Bonner issued a proclamation recognizing the impact of the Small Business Development Center (SBDC) at Troy University in supporting entrepreneurs and strengthening economic development across Butler County.
3D printing business taking off in Chesterfield
Originally built on a $5,000 grant from the University of Missouri’s Entrepreneur Quest Award, followed by $50,000 in Arch Grant Funding, Printerior has its eyes set on continued growth with
What breaks first when your business scales to multiple locations
Stamps.com reports that multi-location growth reveals operational misalignments and that managing varied tools and vendors complicates efficiency and increases costs.
AI-powered ads are driving US ad growth: Madison and Wall
Tools like Google's Performance Max and Meta's Advantage Plus are driving a lift in AI-powered advertising revenue, per Madison and Wall.
ICF International Flags 2026 Growth Rebound as Federal Headwinds Ease, Energy Business Accelerates
ICF International (NASDAQ:ICFI) executives outlined the company’s business mix, recent federal headwinds, and growth priorities during a discussion hosted by Canaccord Genuity Senior Research Analyst Jason Tilchin. Anne Choate, president, and Kyle Wiggins, senior vice president for Energy, Environme
Illinois businesses shift into growth mode after strong 2025
Local companies are confident after surviving years of high interest rates, inflationary pressure and tariff uncertainty, says a new BMO outlook.
Does Tencent Music Entertainment (TME)ʼs New Dividend Signal Evolving Capital Priorities or Strategic Caution?
Tencent Music Entertainment Group has reported fourth-quarter 2025 revenue of CNY 8,641 million and net income of CNY 2,203 million, and for the full year 2025 revenue of CNY 32,902 million and net income of CNY 11,056 million, alongside declaring an ordinary annual cash dividend of US$0.12 per share or US$0.24 per ADS totaling about US$368 million. Beyond the headline growth in revenue and earnings, the decision to distribute a sizeable cash dividend highlights Tencent Music Entertainment’s...
The next business advantage isn’t AI. It’s thriving workers
Research shows companies that invest in employee well-being, purpose and growth outperform those focused only on short-term gains.
BrightSpring Health (BTSG) Climbs 7.8% on Double-Digit Growth Outlook
BrightSpring Health Services Inc. (NASDAQ:BTSG) is one of the 10 Stocks That Made Millionaires Today. BrightSpring rallied for a second day on Tuesday, jumping 7.81 percent to finish at $42.10 apiece, as investors welcomed the company’s reaffirmed growth outlook for this year. In a shareholders’ meeting on the same day, BrightSpring Health Services Inc. (NASDAQ:BTSG) […]
Prudential New Business Profit Climbs on Hong Kong, China Growth
Prudential Plc’s new business profit rose, thanks to growth in Hong Kong and China markets, as the insurer said it will buy back an additional $1.2 billion in its own stock.
Indiana commits $1B to attract high-wage life science jobs
Indiana is dedicating $1 billion to further growth of agriculture and life science businesses and jobs to the central Indiana area over the next 10 years.
The LYCRA Company to Eliminate More than $1.2 Billion of Debt through Prepackaged Restructuring Process, Positioning Business for Long-Term Financial Stability and Growth
WILMINGTON, Del., March 17, 2026--The LYCRA Company to Eliminate More than $1.2 Billion of Debt through Prepackaged Restructuring Process
Rachel Reeves to call for rapid AI adoption and deeper ties with EU to boost growth
Rolling coverage of the latest economic and financial news
Nvidia adds Hyundai, BYD and other automakers to self-driving tech business
AVs are important to Nvidia as self-driving cars remain one of the primary areas where the company can show growth outside of artificial intelligence.
How plants moved from sea to land and changed Earth forever
A geoscientist explains how the first plants came to exist on Earth, long before the dinosaurs, and how their growth shaped life on our planet as we know it.
Abilene business expo to offer connections for growth this month
More than 170 local businesses will gather at the Abilene Convention Center this month for the 2026 Business Expo.
Lawmakers hear how rural women face risks to give birth
Despite modest growth in the number of OB physicians and certified nurse midwives, dozens of North Carolina counties have no clinicians or facilities for care.
Yampa Valley Regional Airport awarded $3 million grant for Aviation Business Park
Routt County has secured a $3 million federal grant to advance infrastructure work at the Yampa Valley Regional Airport’s Aviation Business Park, a project expected to boost economic growth and create jobs across Northwest Colorado, according...
How Meta's AI data center is sparking big changes in this north Louisiana city
After decades of disinvestment and outmigration, Monroe, Louisiana is having a moment, thanks to the Meta data center under construction in nearby Richland Parish. Still unclear is whether the city and surrounding region can leverage the new investments for long-term growth after the construction boom is over.
NHS and MoD will be urged to buy British tech to drive growth amid Iran crisis
Treasury minister Spencer Livermore trails new strategy as chancellor pins hopes on benefits of AI amid global uncertainty
US economic growth revised lower in fourth quarter
The U.S. economy grew at a rate of 0.7% in the fourth quarter of 2025, according to a second estimate released on Friday by the Bureau of Economic Analysis.
Scientists find a new therapeutic target present on up to half of all tumors
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth ...
Inside the explosive growth of sports betting
As part of his investigation into sports betting, Atlantic journalist McKay Coppins gambled $10,000 during last NFL season. He spoke with co-host Tonya Mosley about his experiment, what he learned, and what the explosion of betting is doing to society. “It’s turning all of American life into a Las Vegas table game. There’s always this kind of glittering mirage of profit that you’re chasing, when, in reality, it’s designed to sort of demoralize and crush every regular person who plays.” They also talk about how betting has expanded to politics and international conflict.
Textron (TXT) Wins Mario Gabelli’s Support on Growth in Business Jets and V-280 Defense Program
Textron Inc. (NYSE:TXT) is one of the best stocks to buy according to billionaire Mario Gabelli. Textron Inc. (NYSE:TXT) is one of the companies in GAMCO Investors’ portfolio where the hedge fund has actually increased its stake from its position from more than a decade ago. As of the end of Q4 2025, GAMCO had 1.38 […]
Joseph L. Moore on Why Minority-Owned Businesses Need Trusted Risk Advisors as Growth Expands Across the U.S. Middle Market
His firm specializes in commercial property and casualty insurance consulting, along with safety strategy and loss control advisory for businesses operating in the middle market.
Opinion: Georgia risks 'best state to do business' stature with data center bills
Georgia is a leader in data center growth and construction, but those gains could be imperiled if legislative proposals pass to stymie the industry.
Newberry business owners react to city’s growth
Business owners in Newberry are working to manage the positive and negative aspects of the city’s growth.
We're aiming for a 100% growth rate of the AI server business in 2026: Asus co-CEO
S.Y. Hsu, co-CEO of Asus, says it's "highly possible" that enterprise and commercial products will be the highest revenue grossing segment of the company, and that they are aiming to begin mass production of Nvidia Vera Rubin servers in 2026. He also expects the current shortage of memory chips to last until Q4 of 2027.
Ford launches new AI to grow multibillion-dollar Pro commercial business
Ford CEO Jim Farley last month said diversifying Pro's revenue — specifically in software — is a crucial growth area for the company.
When It Comes to Small Business Clients, Customer Experience is Everything
New research pinpoints client satisfaction as the most important driver of growth in business banking. Master the five key deliverables.
Priority Unified Commerce Strategy Drives Growth Across All Business Segments
Priority Technology Holdings saw growth across its three segments in the fourth quarter as customers sought the payments and treasury solutions delivered
Burnham Says His Bond Market Remarks Were ‘Twisted for Political Reasons’
Andy Burnham, the mayor of Greater Manchester and potential leadership challenger to Prime Minister Keir Starmer, said his comments last year that Britain was “in hock” to the bond markets had been “twisted for political reasons,” and blamed successive Westminster governments for failing to boost growth.
‘LaPolitics:’ State’s new strategic plan targets energy growth
In an effort to bolster and grow a core of its overall business portfolio—the energy and process industries—Louisiana has overhauled and reorganized related regulatory departments and commissioned its first targeted strategic plan in two decades. Louisiana Economic Development commissioned the strategic plan, which zeroed in on the energy and process industries as the most lucrative […]
How Portland's business challenges ripple across Oregon
The city's economic growth depends on restoring livability.
Scientists discover molecule that stops aggressive breast cancer in its tracks
Scientists at Oregon Health & Science University have developed a new molecule that could open the door to treating triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. The compound, called SU212, targets and disables a key enzyme that cancer cells rely on to fuel their growth. In tests using humanized mouse models, the molecule caused tumors to shrink and slowed the spread of cancer by forcing the enzyme to break down.