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How to beat Gigantamax Pikachu: Best Counters & Guide
Gigantamax Pikachu is a Tier 6 Max Battle in Pokémon GO. It will cost 800 Max Particles to participate in this Max Battle, which will only be consumed if you defeat Pikachu successfully. Gigantamax Pikachu can be shiny from Max Battles. Being an type, it is only weak to type moves. Pikachu can be caught […]
Staff revolts, secret meetings: Inside the tense fight between Mike Pence and the Heritage Foundation
Mike Pence used to dream of following two successful Donald Trump terms with his own turn in the White House.
When Voters Worry About ‘Affordability,’ Many Point to Health Care
Democrats have had limited political success running on the Affordable Care Act, even with its relative popularity. Now President Trump’s health care cuts may have given the issue new resonance.
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
US soccer legend Landon Donovan opens up on mental health struggles, redefining success
American soccer legend Landon Donovan opened up about mental health struggles and reconfiguring what success meant to him. He releases "Landon: A Memoir" this week.
B.C. recruits 400 healthcare workers, most from Washington and Oregon
A successful targeted campaign recruited more than 400 U.S.-trained healthcare professionals to British Columbia, many of whom are from Oregon and Washington.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed
A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.
France Is Voting for Thousands of New Mayors. Here’s Why It Matters.
The far-right party had first-round successes in several cities, but so did the far left. Sunday’s second round may clarify who has real momentum.
Mainieri out as South Carolina's baseball coach in 2nd season
Paul Mainieri is out as South Carolina's baseball coach midway through his second season after he couldn't approach the level of success he had produced at LSU.
Building Brighter Tomorrows: Advancing Community Health in 2026 and Beyond
The Institute for the Advancement of Community Health, in partnership with the Institute for Child Success, is hosting the 2026 Building Brighter Tomorrows Conference on Thursday, April 16 at Furman […]
How New Mexico Became an Obamacare Success Story
Affordable Care Act enrollment has dropped across the United States since the enhanced federal subsidies expired. But New Mexico has record numbers of people signing up.
Anthropic just shipped an OpenClaw killer called Claude Code Channels, letting you message it over Telegram and Discord
The consensus among early adopters is that Anthropic has successfully internalized the most desirable features of the open-source movement—multi-channel support and long-term memory
High-speed combat drone production starts at new US Anduril plant in days
Anduril Industries will begin building its new FURY, "loyal wingman," high-speed combat drones in the coming days at a new facility in Ohio, as the U.S. military's interest in unmanned aircraft surges following battlefield successes in Ukraine and Iran.
Del Monte Foods Successfully Completes Sale Transactions Across All Business Segments
/PRNewswire/ -- Del Monte Foods Corporation II Inc. (the "Company" or "Del Monte Foods"), a leading producer, distributor, and marketer of premium quality,...
DCM Acquires Ascot Elite Entertainment As Part Of Succession Plan
Swiss Film Distribution Merger: DCM Acquires Ascot Elite Entertainment As Part Of Succession Plan
NEW DATA: Florida Small Business Owners Confident About Future Growth
Sunshine State remains a top state for small business success
Interventional radiology breakthrough in portal vein thrombosis treatment
A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.
NFL Writer suggests potential Travis Kelce successor for the Chiefs
NFL Writer suggests potential Travis Kelce successor for the Kansas City Chiefs | @EdEastonJr
Frameshift: How Caitlin Vander Weele made science communication her business
Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.
Frameshift: How Caitlin Vander Weele made science communication her business
Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.
Montana senator pulls a fast one to boost preferred successor
Incumbent Steve Daines timed his retirement to all but guarantee his preferred successor will replace him. Never mind what voters, or other hopefuls, had in mind.
CA lawmakers pushes forward bill to curb mental health diversion for public safety
Opponents of the measure say the drive to restrict the diversions neglects statistical success.
Chapelle’s power hitting senior nears end of five-year run as a two-sport varsity standout
The roots of Kelsie Schmidt’s success as a two-sport standout at Chapelle began on the spray-painted lines of a basketball court outside her family home in Kenner.
Good vibes only? The science behind optimism and manifestation
Psychologist Deepika Chopra says that optimism isn’t about being positive all the time. It’s about staying open, curious and resilient. In her new book, The Power of Real Optimism, she explains the science behind optimism and evidence-based manifestation, and how affirmations done the right way can lead to success. Follow us on Instagram: @nprlifekitSign up for our newsletter here.Have an episode idea or feedback you want to share? Email us at lifekit@npr.orgSupport the show and listen to it sponsor-free by signing up for Life Kit+ at plus.npr.org/lifekit
Fishing shop says business is unusually good for March, but warm winter could hurt them down the road
With temperatures expected to push record highs for March later this week, typically summer-oriented businesses are experiencing an early-season boost in success. While things are looking good in t…
Gen Z Loves This Old-School Way of Shopping — But With a Twist: ‘Lines Out the Door’
Successful brands are meeting their young consumers where they want to be.
Apple quietly launches AirPods Max 2
The successor to its premium headphones cost $549 and are launching with enhanced active noise cancellation, the H2 chip, live translation, better sound quality, and more.
Apple unveils AirPods Max 2 with H2 chip, Live Translation, more
Apple has announced the official AirPods Max successor today. Years after the original model was introduced, AirPods Max 2 are...
Berkshire Hathaway sends bullish signal with $225M stock buyback
Warren Buffett halted stock buybacks during his last 18 months as CEO. His successor, Greg Abel, spent $225 million on them in one day.
Thompson Scholars Program preparing future pre-health professionals for early success at UTC
The University of Tennessee at Chattanooga is offering incoming and transfer students an opportunity to strengthen their math and chemistry skills before the fall semester begins through the Thompson Scholars Program, a selective summer bridge experience designed for students pursuing professional health care careers.
Scientists just discovered a tiny signal that volcanoes send before they erupt
A new detection method called “Jerk” could dramatically improve how scientists forecast volcanic eruptions. By using a single broadband seismometer, the system can detect extremely subtle ground movements caused by magma pushing underground—often hours before an eruption begins. Tested for more than a decade at the Piton de la Fournaise volcano on La Réunion, the tool successfully predicted 92% of eruptions between 2014 and 2023, sometimes giving up to eight hours of warning.
MacBook Neo Components Required A ‘Rethink’ From Apple To Get Down To That $599 Price, New Report Says A Touchscreen In Newer Models Isn’t ‘Plausible’
A touchscreen isn’t making its way to a successive MacBook Neo model, as Apple found it very difficult to bring the notebook down to that low $599 price
Local couple’s honey business buzzes on national TV
A local couple — who are Indian Lake alumni — are experiencing swift, sweet success after their products debuted last week on the popular cable […]
The founder of $100M brand Late July and Nixie started selling $1 cookies at 12 and learned the snack trade from the founder of Cape Cod chips—her dad
Nicole Bernard Dawes, the founder of Late July and Nixie, got her start in business selling $1 cookies at local delis—the lessons she learned from the $500 summer hustle led to multimillion-dollar success.
Beachwood Schools news: High school Science Olympiad team is first in regionals; girls track & field wins ind
In Beachwood City Schools news, the Beachwood High School Science Olympiad team won its regional competition; the school's girls track & field team won an indoor title; and thre middle school Mathelete team also found success.
Who Will Be the Packers’ Next Quarterback Redemption Story?
The Green Bay Packers have become victims of their own success. Matt LaFleur has had to rely on backup quarterback Malik Willis several times over the past two seasons. Willis stepped up impressively, leading the Packers’ offense to nine touchdowns with only one turnover in 11 games. Willis clearly benefited from working with LaFleur and the […] The post Who Will Be the Packers’ Next Quarterback Redemption Story? appeared first on The Lead.
White House says it’s ‘done’ with vaccines. MAHA begs to differ
As Trump political advisers try to move on from vaccine policy debates, MAHA movement insiders push back, calling RFK Jr. supporters vital to GOP's success.
Kansas State targeting Belmont's Casey Alexander as next coach as Wildcats close in on Jerome Tang's successor
Alexander helped Belmont win the Missouri Valley Conference regular-season title this year
Successful Business Development Is All About Authenticity
Cravath and Debevoise’s former chief marketing officer, Deborah Farone, shares insights into business development from top women lawyers.
Syracuse hires Toledo AD Bryan Blair to lead Orange athletic department
Bryan Blair, the AD at Toledo, has been hired as the successor for Syracuse AD John Wildhack.
After a successful launch weekend, Pokopia has become one of the best-selling Pokémon spin-offs ever
It is fair to say Nintendo's new Animal Crossing-like Pokémon Pokopia has had a pretty darn successful launch.
The MacBook Pro M5 Max Is So Fast, It's Hard to Know How to Test It
A more exciting MacBook Pro is waiting in the wings, but the M5 Max shows the continued success of Apple Silicon.
Bookman: Has the Kemp model fallen out of fashion in Georgia politics?
Brian Kemp, in his eighth and final year as governor, still enjoys significant popularity. In an Emerson poll conducted last weekend, only 24.5% of Georgians said they disapprove of his job performance, which in this divisive era is remarkable. You might think that kind of long-running success would make Kemp a model to be emulated […]
Iran war complicates the economic pivot GOP badly wants to see from Trump
President Donald Trump has tried — at least occasionally — to maintain focus on the domestic priority his advisers believe is essential for GOP success in November’s midterm elections. But the Iran war has badly complicated his attempts at an economic pivot.
Breakout Ventures raises $114M fund to back AI science startups
Breakout Ventures is finding growing success by backing early-stage startups in scientific fields such as biology and chemistry.
Microsoft Confirms SQL Zero-Day Security Vulnerability—Here’s The Fix
Microsoft has confirmed that a hacker who successfully exploits a zero-day SQL vulnerability could gain system administrator privileges. Here’s how to fix it.
6 Things To Know Before Starting A Business In Panama
I've built a successful business in Panama over the past two decades. Here are my six tips for prospective entrepreneurs.
UI Health Care performs its first robotic living donor nephrectomy
University of Iowa Health announced in early February 2026 that it had successfully completed its first robotic living donor nephrectomy
Scientists Are Trying to Train Lab-Grown Brains. The Brains Have Started to Solve Problems.
Scientists trained a brain organoid to solve a well-known engineering task, and its success demonstrates the increasing complexity of lab-grown brains.
Nintendo Shares Rally 10% as New Pokémon Game Lifts Sentiment
Nintendo Co. shares soared as much as 10% in their steepest climb since April as the surprise success of its new Pokémon game helped offset worries around the rising cost of memory chips.
Burnham Says His Bond Market Remarks Were ‘Twisted for Political Reasons’
Andy Burnham, the mayor of Greater Manchester and potential leadership challenger to Prime Minister Keir Starmer, said his comments last year that Britain was “in hock” to the bond markets had been “twisted for political reasons,” and blamed successive Westminster governments for failing to boost growth.
Georgia voters are choosing a successor for Marjorie Taylor Greene
The winner will serve out the remaining months of Greene’s term. But if they want to remain in Congress beyond next January, they will have to run again.
Why is Trump gamifying the war in Iran?
The White House is posting ‘video-game vibe’ content to promote US success in the Middle East conflict
Georgia votes for successor to Marjorie Taylor Greene after Trump spat
Trump’s pick of former prosecutor Clay Fuller likely to face Democrat and retired general Shawn Harris in runoff for House seat
Georgia voters choosing a successor to Marjorie Taylor Greene in US House
Georgia voters are heading to the polls to choose a successor in Congress to Marjorie Taylor Greene
Small businesses that successfully sued over Trump tariffs relaunch fight against new levies
Gave up traveling full-time with family, successful YouTube career
I traveled full-time with my family for years and posted on YouTube. We gave up that lifestyle, but I worry about the negative impacts on our kids.
Business for Good 2026
Maine companies are increasingly recognizing that success is measured by more than profit alone. Research shows that people value businesses that operate responsibly by protecting the environment, supporting their communities, and fostering workplaces built on shared purpose. Business for Good spotlights the Maine organizations, large and small, that are driving positive change through community involvement, responsible growth, and purpose-driven leadership.
Sphere Entertainment Demand And Expansion Hopes Meet Valuation Debate
Sphere Entertainment (NYSE:SPHR) reports strong consumer demand at its Las Vegas Sphere venue. The company highlights substantial success for its new production of "The Wizard of Oz." Management is seeing increased interest in expanding the Sphere concept to additional U.S. and international locations. Sphere Entertainment, the company behind the Las Vegas Sphere, focuses on large scale immersive entertainment venues that blend live events with advanced audio visual technology. The strong...
From the publisher: Business leaders are channeling CSR values into innovative models
Across the state, companies are redefining what success looks like. Profit remains essential. Growth matters. But more leaders are asking a broader question, What impact are we having on our employees, our communities and the environment we all share?
OnePlus 15T: Official first look at new compact flagship phone revealed
The successor to last year's OnePlus 13T is confirmed to launch soon in China. The OnePlus 15T has been officially revealed in two colorways, with a design language that closely resembles the standard OnePlus 15 and the 13T.
Magic handle Bucks to win 4th in a row
Speaking pregame ahead of Sunday’s contest between the Magic and Bucks, Orlando coach Jamahl Mosley pointed towards his team’s ability to set the tone early as a major factor behind Saturday’s win at Minnesota. One night later at Milwaukee, the Magic followed a similar recipe for success, scoring the first seven points of the game, limiting the Bucks to 15 points in the opening quarter and ...
Luka Doncic issues stern challenge after Knicks win
Lakers star Luka Doncic spoke about what the team needs to continue to do in terms of defense to be successful.
Local business owners to share experiences at workshop for entrepreneurs
ESCANABA — Several downtown Escanaba business owners will share their experiences starting and developing businesses during the next Project Point workshop this Wednesday in Escanaba. The event is the second session in the “Project Point: Guiding Businesses to Success” series, designed to help Delta County entrepreneurs learn from local business leaders. The free workshop is […]
Rapper-Turned-Politician Is Set to Be Nepal’s New Prime Minister
The success of Balendra Shah, known as Balen, reflects the hope he can address economic grievances behind recent Gen-Z protests.
NH's Business: Common Man Roadside business model
Fred Kocher sits down with Brad Pernaw with MGN to talk about the success of the Common Man roadside and restaurants across the state.
Public school teacher redefines success as she homeschools her kids
As a former public school teacher, I was surprised by what homeschooling my own kids taught me about learning beyond grades and test scores.
Millions of jobs vulnerable as ‘silver tsunami’ looms over US small businesses, experts warn
Nearly half of U.S. small-business owners are 55 or older, and with many lacking succession plans, jobs and local economies could face disruptions in the coming decade, experts warn.
A Grip on Sports: There is something special about watching the joy that comes with reaching a goal, no matter how difficult the journey was
A GRIP ON SPORTS • If there is any way to turn back the clock, how many of us would do it? This morning, when Daylight Saving Time kicks in, pretty much everyone. But when faced with the metaphorical, looking back on our past successes and failures, the question is a lot harder to answer, isn’t it?
Women in Science: Alice Schlichtiger on Leadership, Mass Spectrometry, and Impact
In this interview, Dr. Alice Schlichtiger discusses her journey from academia to industry and shares her advice on building a successful career in science.
Apple's Strange TikTok Videos Capturing Gen Z's Attention
Apple is promoting the MacBook Neo with a series of intentionally strange TikTok videos that are successfully capturing Gen Z's attention. Since Thursday, Apple has been posting the videos in sets of three, with each video corresponding to one of the MacBook Neo's Blush, Citrus, and Indigo color options. The laptop also comes in Silver, so there may be a final set of videos tomorrow.
NASA successfully kicks asteroid off course in Earth defence test
NASA knocked an asteroid off course in 2022 in a pioneering test of humanity's ability to defend Earth. Its spacecraft's impact pushed the space rock into a slightly different orbit around the Sun, according…
The Wolf of Call Street: New College of Business elevates campus
The new Herbert Wertheim Center for Business Excellence both takes students out of their typical routine and encourages them to strive for success.
Slay the Spire 2's launch has been so incredibly successful, the studio had to apologise for a joke about Marathon that now "seems a bit meaner than it was intended"
Game developer behind Slay the Spire 2 has assured people that their congratulations message to the Marathon team wasn't meant to read as mean.
Analysis | Since when do senators anoint their successors?
The Washington Post’s essential guide to power and influence in D.C.
A little butter and a lot of passion: Black Box Bakery perfects the recipe for a successful small business
Black Box Bakery opened in the Edgewater Public Market and has quickly become known as one of the top bakeries in the Denver area. How did they do it? With professionals who take pride in their work.
Scientists Cut Amyloid Plaques by 50% in Mice With Engineered Cells
"This study marks the first successful attempt."
Adios, Kristi Noem. You Won’t Be Missed.
Unfortunately, her successor might be just as loony.
Trump Says He Should Have Role in Picking Iran’s Leader
The president’s comments were the most explicit he has been yet about his vision of an American role in creating a new government in Tehran.
3L Kevin Afiesh Learns to Translate Legal Risk Into Business Strategy as FinTech Extern - UC Law San Francisco (Formerly UC Hastings)
3L Kevin Afiesh strengthened his corporate and fintech skillset through an externship at Plaid, gaining real-world experience at the intersection of technology and financial services. 3L student Kevin Afiesh shares how UC Law San Francisco’s Corporate Counsel Externship provided immersive, practice-ready training inside Plaid’s in-house legal department. Reviewed and analyzed technology-focused agreements, including emerging AI provisions and liability terms Explored financial services regulation and data governance within a growth-stage company Learned how internal legal teams shape product, partnership, and compliance planning 3L student Kevin Afiesh: During my externship at Plaid, I worked with the in-house legal team supporting a rapidly growing company at the intersection of technology and financial services. My work focused primarily on corporate, commercial, and intellectual property matters. I helped review and analyze vendor and partnership agreements, paying close attention to emerging artificial intelligence-related provisions and risk allocation terms. I also investigated regulatory and compliance issues involving financial services and data governance, and I researched intellectual property litigation relevant to fintech companies. This work supported legal risk assessment to guide strategic decision making. I learned firsthand how an in-house legal team operates in a highly regulated, innovation-driven environment, where legal analysis is closely integrated with business decision making. I saw how attorneys balance legal risk with commercial priorities and how their advice shapes contracting, compliance, and intellectual property strategy. It reinforced that effective in-house lawyers need to understand both the law and the operational realities of the business. The experience also strengthened my ability to communicate complex legal concepts clearly to non-lawyers and to provide advice that is precise, practical, and commercially aware. Throughout my academic and professional journey, I’ve worked with technology companies at different stages. Plaid added a distinct perspective within the tech ecosystem, showing me how a growth-stage fintech company approaches regulatory complexity, innovation, and risk tolerance. This sharpened my ability to adapt to clients with different structures, priorities, and compliance needs. As I prepare to practice corporate law in the technology industry, this exposure has strengthened my ability to align legal advice with a company’s stage of growth, strategic objectives, and internal dynamics. I would absolutely recommend the Corporate Counsel Externship Program. Working directly with an in-house legal team provided a meaningful sense of day-to-day practice inside a technology company, and the attorneys at Plaid were generous with their time and mentorship. The classroom component was equally valuable. Professors Nira Geevargis and Scott Darling created a thoughtful environment where we reflected on our experiences, discussed real-world challenges, and developed practical skills that complemented our fieldwork. More broadly, UC Law San Francisco’s location offers a clear advantage for students interested in technology, corporate practice, and public-interest work. Proximity to courts, law firms, and innovative companies — combined with programs like the Corporate Counsel Externship and an extensive Bay Area alumni network — make it a strong option for students who want to build their careers in the region. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
There is no magic formula for business success, Texas A&M researcher finds
Mays Business School professor highlights flexibility and learning from mistakes as essential for professional growth.
How a successful Colorado startup turned into a nearly $1 billion health care fraud scheme
Zynex served as a Colorado startup success story — a one-man operation turned public company with hundreds of millions of dollars in revenue. This is the story about how it all fell apart.
Who is Mojtaba Khamenei, Iran’s Leader Possible Successor?
If Mojtaba Khamenei were chosen as Iran’s next supreme leader, it would be historically significant for Iran and the region.
OnePlus 15T: New compact flagship surpasses Xiaomi 17 Pro and Vivo X300 with larger battery
The OnePlus 15T is set to launch as the successor to the OnePlus 13T, which featured a 6,260mAh battery with 80W wired charging but lacked wireless charging support. Now, the company has officially confirmed that the 15T will pack a 20% larger battery than its predecessor.
Iran’s succession question: Rouhani’s name resurfaces amid leadership void
Rouhani's legacy of pragmatism and moderation gains renewed relevance amid Iran's sensitive leadership transition phase.
Rhode Island Life Science Hub CEO Mark Turco to step down
Turco’s last day will be March 11. His successor will inherit an agency with big ambitions, and a limited time to prove its worth.
How Mixed-Use Sports and Entertainment Districts Create Year-Round Economic Value
From stadium-anchored destinations to experience districts, successful mixed-use sports and entertainment developments are evolving into adaptable, community-centered places that deliver cultural relevance, financial performance, and economic activity every day.
Redefining Gold: Joy, Alignment, And Winning In Business
What does it really mean to win gold? Shelley Zalis redefines success, where joy, alignment, and values matter as much as results in business and leadership.
The stories behind this year’s Business Awards and Hall of Fame changemakers
The Business Awards & Hall of Fame recognize more than success. They honor the changemakers—people who saw a need, challenged the status quo and built something lasting, often quietly and patiently. In doing so, they helped reshape the economic and civic fabric of the Capital Region and beyond. This year’s honorees reflect that idea in […]
AI@Work in Business
UNCG’s Bryan School launches AI for Impact, an executive workshop helping leaders strategically and ethically integrate AI for future success.
Seymour Studios goes live with new community science podcast
The Seymour Marine Discovery Center launched a new podcast Tuesday to connect Santa Cruz County’s scientists, problem-solvers and community members. While the new show spotlights local environmental success stories, the studio itself offers an inclusive space for anyone in the community to record and share their message, conservation-focused or not.
Fulham v West Ham: Key stats and talking points
East meets west at Craven Cottage on Wednesday night, with Fulham vying to emulate their victory over West Ham in December's reverse fixture. While Fulham have rekindled their hopes of European football with successive wins, West Ham's revival has lost some momentum and they remain two points from safety. Fulham's season is following a similar pattern to their previous campaigns since promotion in 2022 – sat comfortably mid-table or higher heading into March, with aspirations of qualifying for Europe for the first time since 2011.
Anthony Kim Seeking More Success After An Emotional Comeback Win
LIV golfer Anthony Kim reflected on his victory in Australia
Community colleges tout success of state-sponsored business partnerships
Representatives from Iowa's community colleges gathered at the Iowa capitol Tuesday to showcase successes to lawmakers.
In Their Words: How Trump's and his administration's statements on Iran evolved and conflicted
President Donald Trump and his team have given shifting and sometimes conflicting reasons for striking Iran, even as they claim the mission a total success
TransUnion Completes Acquisition of Majority Ownership of the Consumer Credit Business of Buró de Crédito
TransUnion (NYSE:TRU) has successfully completed its previously announced acquisition of an additional 68% of Trans Union de México, S.A., S.I.C., the consumer credit business of Buró de Crédito, the largest credit bureau in Mexico. The transaction brings TransUnion’s total ownership to approximately 94%. TransUnion will operate this busine...
TransUnion Completes Acquisition of Majority Ownership of the Consumer Credit Business of Buró de Crédito
CHICAGO, March 02, 2026 (GLOBE NEWSWIRE) -- TransUnion (NYSE:TRU) has successfully completed its previously announced acquisition of an additional 68% of Trans Union de México, S.A., S.I.C., the consumer credit business of Buró de Crédito, the largest credit bureau in Mexico. The transaction brings TransUnion’s total ownership to approximately 94%. TransUnion will operate this business under the commercial name of Buró de Crédito going forward. Cash consideration for the transaction is approxima
Meet the 2026 SiouxFalls.Business 30 Under 30
They're finding early career success and already giving back to their community. Meet this year's 30 Under 30, presented by MarketBeat.