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This One Fruit May Reduce The Nutrients in Your Next Smoothie, Experiments Suggest
Oh damn.
'Tanmaxxing' trend could come at a dangerous cost, skin cancer experts warn
A dermatologist warns that "tanmaxxing" is causing DNA damage, calling the Gen Z tanning trend a "visible distress signal" rather than a wellness upgrade.
Every wild detail from Taylor Swift and Travis Kelce's MSG wedding — from arcade games and 'JUST&T MARRIED' to an Adam Sandler cameo
The couple kept photos and details tightly under wraps. But guests, staff and celebrity friends have started leaking small glimpses into the wedding of the year.
Cranston business damaged after car crashes into it
CRANSTON, R.I. (WPRI) — A business in Cranston was significantly damaged after a car crashed into it late Friday night. According to police, just after 11 p.m. a juvenile boy was driving alon…
The greatest college football team of every decade, from the 1920s to today
From Notre Dame's Four Horsemen to Nick Saban's dominant Alabama squads, these programs defined the last 100 years of college football
Happy Independence Day Dawg Sports!
It’s July 4th, the day we celebrate one of history’s earliest and most impactful conference realignments. The decision by our founding fathers that the British Empire’s revenue sharing model just wasn’t for them, and became the Notre Dame of the Western Hemisphere, geopolitically speaking. Their fateful decision saved us from a number of indignities, such […]
AMC CEO shares play-by-play of Taylor Swift and Travis Kelce’s wedding
AMC CEO Adam Aron shared a very detailed recap of Taylor Swift and Travis Kelce’s wedding at Madison Square Garden, from the decor to the vows.
America at 250: Small business still carries the water
Guest essayist Chuck Violand writes as America turns 250, let's recommit to the values that helped build strong businesses and a strong country.
Ireland, as 'honest broker', reckons with the price of dirty business
Ireland is facing the music over its continued sales of alumina to Russia. The scandal put a damper on the start of the country's EU presidency and raised uncomfortable questions that Dublin has yet to answer.
Fight them for the beaches: the real villain of Europe’s overtourism is big business
From Albania to Portugal, privatisation of the coastline is bringing locals out on to the streets. For them, the economic benefits are few and far between, says Adam Almeida, a writer living in London
Sports world turns out for Travis Kelce and Taylor Swift's Madison Square Garden wedding festivities
Adam Sandler officiated the ceremony as athletes like George Kittle, Kareem Hunt and Matthew Stafford celebrated at Madison Square Garden.
Adam Sandler officiated Taylor Swift and Travis Kelce's wedding
Wait, what? Adam Sandler officiated Taylor Swift and Travis Kelce's star-studded wedding at Madison Square Garden.
Taylor Swift and Travis Kelce are married! Couple wed at Madison Square Garden in a ceremony officiated by Adam Sandler.
Taylor Swift and Travis Kelce are officially married.
Why Adam Sandler officiated the Taylor Swift, Travis Kelce wedding
He wasn’t there as “The Wedding Singer,” but Adam Sandler played a pivotal role in the Taylor Swift-Travis Kelce marriage.
Pro-ballot initiative group submits 108,837 signatures
Backers of a proposed Arkansas constitutional amendment that would make citizen-proposed laws and constitutional amendments a fundamental right submitted 108,837 petition signatures Friday (July 3), the deadline for turning in...
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
Teams Make Contact With Spacecraft Set to Boost NASA’s Swift
Teams have successfully established communications with Katalyst Space’s robotic servicing spacecraft LINK.
NASA’s Hubble Captures Crimson Cloud Sparkling with White, Blue Stars
Blue and white stars shine brightly against glowing crimson gas in this image of stellar nursery LH 95 from NASA’s Hubble Space Telescope.
Mission To Boost NASA’s Swift Launches From Marshall Islands
A mission to raise the orbit of NASA’s Swift observatory has reached orbit.
Apple Responds to Lawsuit Filed by Three YouTube Channels
Earlier this year, three YouTube channels sued Apple, alleging that the company violated the U.S. Digital Millennium Copyright Act (DMCA) by unlawfully accessing and scraping millions of copyrighted YouTube videos to train its AI models. In a class action lawsuit filed with the U.S.
NASA, Partners Update Launch Date for Mission to Boost Swift
The launch of Katalyst's robotic servicing spacecraft LINK is now targeted for no earlier than Friday, July 3.
The real cause of a common stroke may have been missed for decades
Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.
Taylor Swift and Travis Kelce's wedding festivities are officially underway as A-listers arrive to MSG
The latest chapter of Taylor Swift and Travis Kelce's love story is officially underway in NYC as celebrity guests like Adam Sandler and Lena Dunham descend on Madison Square Garden.
AMERICA AT 250: COMPETING CELEBRATIONS REFLECT NATIONAL POLARIZATION, SAYS SMU POLITICS EXPERT
DALLAS (SMU) – As the nation marks its 250th anniversary with separate celebrations in Washington, D.C., and Los Angeles, SMU political scientist Matthew Wilson says the split reflects a deeper reality about modern America: the absence of a shared national narrative. Wilson argues that what should have been a unifying moment of national pride has instead become a symbol of the country's growing political polarization, with rival groups promoting fundamentally different visions of Amer
Amendment 61: A.4 Rapid Response and Novel Research in Earth Science Final Close Date Deferred
A.4 Rapid Response and Novel Research in Earth Science (RRNES) solicits proposals that advance the goals and objectives of NASA's Earth Science Division by
Amendment 60: Final 2025 Due Date Extended for C.2 Solar System Science
C.2 Solar System Science solicits proposals for research, data analysis, data preservation, and tools that support investigations to help ascertain the
Helio and You: Heliophysics as an American Endeavor
Heliophysics is an important cornerstone of the history of astronomy, and many of the pioneers in this field have been American. This article examines a bit of this history in depth.
How a new White House proposal could fundamentally change American science
In this webinar, we discuss the potential impacts of a Trump admin plan to overhaul how federal research grants are awarded and administered.
MediaDailyNews: Microsoft Furthers Trend, Invests $2.5B In AI Consulting Business
Microsoft announced the "Microsoft Frontier Company" on Tuesday as a new operating business focused on delivering AI support for its clients through enterprise AI engineering expertise.
Heat Wave Caused Some 480 Excess Deaths in Netherlands, Health Authorities Say
AMSTERDAM, July 2 (Reuters) - Last week's unprecedented heat wave led to around 480 excess deaths in the Netherlands, Dutch health authorities said on Thursday. • Excess deaths in the week from June 22 to 28 were mainly among people aged 80 years and older. • Most were reported in the ...
NASA’s Webb Reveals Stars Sparking to Life in Cosmic Celebration
NASA’s James Webb Space Telescope has captured the infrared light of numerous features that previously were impossible to see beyond the thick dust of the FS
The White House goes all in on aliens with new UAP Science Advisory Council
This new group, which is led by Harvard professor Avi Loeb, aims to advise the Trump administration and the U.S. intelligence community, as well as to publish its findings in peer-reviewed journals
Launch of Swift Boost Mission Delayed, Teams Reviewing Data
The launch of Katalyst’s robotic servicing spacecraft LINK on Northrop Grumman’s Pegasus XL rocket was postponed Thursday.
Silk flower business destroyed by fire early Thursday in Cobb County
A fire heavily damaged a wholesale silk flower business in Cobb County early Thursday morning.
Is America celebrating the wrong anniversary? John Adams thought so.
The Founding Father anticipated “Pomp and Parade” to mark America’s birthday. But he didn’t think it would happen July 4.
Medicare's health tech spending test
Emerging technologies can improve people's health if we fundamentally change the way the system pays for care.
Summer travel health: tips for heat exhaustion, insect bites and travel vaccines
Stay healthy while traveling with help from CVS Pharmacy and MinuteClinic. Get vaccines, refill prescriptions and prepare for summer travel risks.
Ancient cave paintings can harbor human DNA for millennia, scientists find
The breakthrough could reveal previously hidden ancient human activity inside caves, acting as ‘genetic archives’
Global ocean temperatures are entering “uncharted territory,” climate scientists say
Sea surface temperatures in late June reached nearly 70 degrees Fahrenheit on average, shattering records
Sudden danger: the science and stakes of flash flood forecasting
Flash floods pose a major threat to lives and property. When it comes to researching them, understanding the rain as it falls is only half the battle. The next step is knowing how the water will move once it hits the ground.
ASU scientists unveil new methods to extract reliable truth from imperfect data
Scientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two papers published in Nature Communications and Proceedings of the National Academy of Sciences, the team introduces fundamentally new approaches to solving “inverse problems,” where researchers work backward from noisy observations to uncover the underlying reality.
Lindsey Graham expects housing package to become law despite Trump's election bill demands
"We need the housing bill." U.S. Sen. Lindsey Graham says President Trump shouldn't let Tim Scott's bipartisan housing bill become collateral damage in the fight over the SAVE America Act.
NASA’s Webb Studies How Planet Survived Death of its Star
NASA’s James Webb Space Telescope is giving us new insight into the far-future of solar systems like our own, as the agency continues to reveal the secrets of
How Investors May Respond To PENN Entertainment (PENN) Aurora Casino Opening And Russell 2000 Shift
PENN Entertainment recently celebrated the grand opening of its new US$360 million Hollywood Casino and Hotel Aurora in Illinois, while also being moved from the Russell 1000 family of indices into the Russell 2000, Russell 2000 Value, and Russell 2000 Dynamic indices as part of the latest rebalancing. This combination of a large-scale brick-and-mortar investment and a shift toward small-cap and value-oriented index inclusion reshapes how both fundamental and index-tracking investors may...
Scientists just unveiled “cyborg” cockroaches that can breathe underwater for hours
The bionic bugs could be called up for aquatic search and rescue missions, according to the researchers
Scientists say they have built a cell from scratch for the first time
Scientists say they have built a cell from scratch for the first time that feeds, grows and replicates like a natural cell, a breakthrough in synthetic biology.
Professor, Mentor, Researcher, and Data Pioneer: Celebrating Lynn Blewett’s Retirement
I first met Lynn Blewett as a graduate student at the University of Minnesota School of Public Health, where her courses on the U.S. health care system fundamentally shaped how I understand policy and evidence. What struck me most was her ability to translate complex health systems into their human dimensions and to remind us […]
Four Eagles Named to Athlon Sports Preseason ACC All-Conference Team
Chudzinski, Price highlight list with second-team recognition
Weather Delays Launch of Mission to Boost NASA’s Swift
The launch of Katalyst Space’s LINK, designed to boost the orbit of NASA’s Swift observatory, was postponed again Wednesday due to unfavorable weather conditions.
Quakes strain Venezuela’s health system
LA GUAIRA, Venezuela -- Aid groups warned Tuesday that Venezuela's fragile healthcare system is being pushed to its limits nearly a week after two powerful earthquakes, with damaged and understaffed hospitals getting overwhelmed by the injured and infectious diseases flaring in the disaster zone.
Sacramento business continues to deal with damages a year after 4th of July fire
A year after fireworks sparked a destructive fire, a Sacramento business is still dealing with damages.
America 250 Is Rewriting the Business Case for Made in America
Naturepedic’s Arin Schultz examines why America’s 250th anniversary coincides with a fundamental shift in manufacturing strategy. Schultz argues that tariff uncertainty, supply-chain disruption and…
PAHO expands health response as Venezuela faces mounting health risks after devastating earthquakes
Caracas, Venezuela/Washington, D.C., 30 June 2026 (PAHO) – The Pan American Health Organization (PAHO) is expanding its support to Venezuela's Ministry of Health following the two powerful earthquakes that struck the country on 24 June, deploying technical experts, coordinating international Emergency Medical Teams (EMTs), assessing damaged health facilities, and mobilizing emergency medical supplies to support lifesaving care and reduce the risk of disease outbreaks.
Is the world’s smallest Pepsi bottler also Oregon’s oldest business?
Adam Van Dusen opened a mercantile in Astoria in 1849. The sixth-generation of the family is still in business there today.
Crews called to overnight fire to auto repair business in Boonville
We’re told there was damage to the back corner of the business.
Venezuela health system strained after earthquakes, WHO says
Venezuela's healthcare system is under significant strain, the World Health Organization said on Tuesday, with some hospitals damaged and others missing staff after deadly twin earthquakes last week.
Venezuela Health System Strained After Earthquakes, WHO Says
By Emma Farge GENEVA, June 30 (Reuters) - Venezuela's healthcare system is under significant strain, the World Health Organization said on Tuesday, with some hospitals damaged and others missing staff after deadly twin earthquakes last week. More than 1,700 people have been killed and 5,000 ...
Former NFL star has warning for Commanders about Brandon Aiyuk
One former NFL WR warns the Commanders, especially GM Adam Peters about Brandon Aiyuk.
England maternity commissioner role would be ‘fundamentally dangerous’, says campaigner
Founder of Maternity Safety Alliance says recommendation in Amos report will not solve wider cultural problems
Scientists may have finally found how Alzheimer's spreads through the brain
A common brain protein may be giving Alzheimer’s disease an unexpected way to spread, carrying toxic Tau proteins from damaged neurons into healthy ones. By blocking these harmful protein packages before they reach new cells, researchers believe it may one day be possible to slow the disease's relentless progression.
Northwest Earth and Space Science Pathways Project Celebrates Student Innovation Through ROADS from Earth to Venus National Challenge
The Northwest Earth and Space Science Pathways (NESSP) project recently concluded its 2025–2026 ROADS (Rover Observation And Discoveries in Space) from Earth
MoCo health officer to update County Council on ‘forever chemicals’ in North Potomac waterway
Plus: Public hearing on suggested revisions to water, sewer comprehensive plan
What to Expect: Commercial Mission to Boost NASA’s Swift
A mission to boost the orbit of NASA’s Swift observatory is targeted to launch no earlier than Tuesday, June 30, at 10:17 p.m. UTC+12 (6:17 a.m. EDT).
ROSES-25 A.12 HAMAQ Science Team Clarified
Hemispheric Airborne Measurements of Air Quality (HAMAQ) is a NASA-funded project under the EVS-4 program using two aircraft (NASA’s B777 & P-3B) to
How to spot an AI-generated face, according to science
Training people to pay attention to the right visual cues nearly doubled how accurately they could spot AI-generated faces
Festival in a Box: Amsterdam 2026 Takes the Scenic Route
Festival in a Box: Amsterdam 2026 brings MagicCon home with orange hues, wild beauty, and a scenic detour through the Multiverse.
How Jude Bellingham SAVED England against Panama
England are through to the World Cup knockout rounds following a 2-0 win over Panama. But after another sluggish start, which looked for a while like it could be a repeat of the Ghana game, Jude Bellingham both scored and assisted to get England through. Adam Clery looks at how, without Declan Rice in the side, Bellingham played every single midfield role to drag Thomas Tuchel's side to a vital win.
Kidambi Srikanth loses US Open final: Indian Sports LIVE, June 29
Here are all the updates from Indian sports on June 29, 2026.
First ever dinosaur found in Antarctica described for science
Dinosaur backbone is the first found on the icy continent, and belongs to a titanosaur around 6–7 meters in length.
These fat-filled brain cells may be making multiple sclerosis worse
Scientists have uncovered a surprising clue that may help explain why multiple sclerosis (MS) progresses rapidly in some people but not others. In brain tissue from patients with severe MS, researchers found large numbers of “foamy” immune cells packed with fat droplets after absorbing damaged myelin. These overloaded cells appear to switch from helping repair the brain to fueling ongoing damage and inflammation.
The latest 2026 ODA projections reveal aid for health is further at risk
With official development assistance (ODA) by member countries of the Development Assistance Committee (DAC) projected to fall again in 2026, the health sector is facing deep cuts.
El Niño Is Back—and It Could Cost Businesses Trillions. What Smart Leaders Are to Prepare
Dartmouth research makes the duration of the damage clear: economic losses from major El Niño events persist for five years after the event itself.
Every Notre Dame player drafted by the Boston Celtics
Let's take a look at every player who has been drafted by the Celtics out of Notre Dame.
Common pesticide linked to more than double the risk of Parkinson’s disease
Scientists at UCLA have linked long-term exposure to the pesticide chlorpyrifos with a sharply increased risk of Parkinson’s disease. People exposed to the chemical near their homes were more than twice as likely to develop the condition. Laboratory studies showed that chlorpyrifos damages dopamine neurons and interferes with the brain’s ability to remove toxic protein buildup.
Scientists Challenge a Fundamental Assumption About Consciousness
A new philosophical study challenges the idea that consciousness requires human-like biology.
ChaosCollage
Already teaming up for the Chaos Spreads challenge? Submit a screenshot of you and your friends in Minecraft via Gleam.io for a chance to feature in our end-of-summer chaos collage! Find out more in this article
Hurricanes follow Stanley Cup title by looking at how to improve roster
Carolina doesn't have a lot of free-agency decisions after winning the team's first Stanley Cup title in 20 years.
Juri gets her own Street Fighter Masters special from UDON Entertainment
UDON Entertainment has announced that Juri Han is set to round out the publisher’s Street Fighter Masters series of one-shot comics with her very own special from writer Adam Warren and artist M…
49ers News: Gotta let the Bosa Brothers dream go…
Adam Schefter believes Joey Bosa has played his last down in the NFL“Bosa turns 31 in July. Last year was the first time he appeared in double-digit games since 2021. The 49ers would pursue an edge rusher if Nick or Mykel Williams are behind the 8-ball on their rehab. Some believe Mykel begins the season […]
Screen time can damage under-twos’ development, landmark study suggests
Exclusive: Researchers call for urgent investigation of risks to babies of tablets, smartphones and other digital devices
Applications open for Hawaii County Kona low business recovery program
Eligible businesses can use the money for recovery needs, including equipment repair, temporary relocation costs and water damage.
Applications open for Hawaii County Kona low business recovery program
The reward from the county can be used for recovery needs, including equipment repair, temporary relocation costs and water damage.
Community Challenge Chaos Spreads
To celebrate the release of the Chaos Cubed game drop, the mayhem continues with our Chaos Spreads Community Challenge! Unite with your friends and play with the free add-on reward, courtesy of completing the Chaos Sparks Community Challenge. Players can collectively win a new Bedrock world for all from Blockception!
NASA’s PACE Mission Studies Smoke, Fires
With the North American fire season underway, and a record number of acres already burned nationwide, NASA’s Plankton, Aerosol, Cloud, and ocean Ecosystem
New study suggests health damage from exposure to Ohio toxic train spill
Research finds immune systems still ‘responding to toxic chemical exposures’ related to East Palestine derailment
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
Notre Dame 2026 Player Profile: Wide Receiver Devin Fitzgerald
As the son of an NFL legend, this physical Arizona standout is already flashing elite route-running and contested-catch skills after a dominant spring debut in South Bend.
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street
Corporate dark money groups are funneling millions into eleven different races statewide.
Heastie brushes off growing DSA influence, defeat of incumbents in Albany
Heastie sought to put the results into context while speaking with reporters at an unrelated event in Schenectady on Thursday.
Octavia Spencer's Orit Entertainment Names New Heads Of Film & TV
Octavia Spencer's Orit Entertainment has made two key executive hires, naming Kathryn Tyus-Adair as Head of Film and Adam Wagner as Head of Television
Octavia Spencer’s Orit Entertainment Names Kathryn Tyus-Adair Head Of Film & Adam Wagner Head Of Television
EXCLUSIVE: Octavia Spencer’s Orit Entertainment has made two key executive hires, naming Kathryn Tyus-Adair as Head of Film and Adam Wagner as Head of Television. “Kathryn and Adam are exceptional exe...
Men’s Health Month reminds community members to catch up on overdue wellness visits
June is Men’s Health Month and experts are urging men not to ignore crucial preventative care.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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