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Do the Miami Heat Have a Point Guard Depth Problem?

Patrick Beverley questions the Miami Heat's backcourt stability, sparking a debate on whether Erik Spoelstra’s developmental gems and potential veteran additions can fuel another deep championship run.

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Sep 9 • 4:30 PM EDT • Sports • sports.yahoo.com
Apple Adds AppleCare One Family Plan for Up to Six People

Apple today announced AppleCare One Family, a new option for U.S. customers that extends AppleCare coverage to every eligible device across an Apple Family Sharing group of up to six people for one fixed monthly price. AppleCare One Family costs $49.99 per month and includes all of the same benefits as AppleCare+, such as coverage for accidental damage like drops and spills, battery replacement service, and priority support from Apple Experts.

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Sep 9 • 4:23 PM EDT • Technology • macrumors.com
What to know about Missouri's confusing battle over congressional districts

Missouri's redistricting battle has left voters confused just two months before a crucial November election. Conflicting court rulings have left many people unsure about which U.S. House districts they will

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Sep 9 • 4:01 PM EDT • Politics • kdhnews.com
A closer look at Amazon's drone delivery operation in Baton Rouge

Amazon's Prime Air drone delivery operation in Baton Rouge is part of a broader expansion that aims to bring the service to nearly 500 cities and towns by the end of the year, according to operations … Already an INSIDER? Sign in. Already an INSIDER? Sign in

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Sep 9 • 3:56 PM EDT • Business • businessreport.com
Michael J. Fox’s Parkinson’s battle has ‘gotten harder,’ but he’s hopeful

NEW YORK — Michael J. Fox’s battle with Parkinson’s disease has “gotten harder,” but he remains optimistic that a cure is coming. The 65-year-old television star was 29 years old

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Sep 9 • 3:25 PM EDT • Entertainment • recorderonline.com
Welcome back to the regular season in the Midcoast business scene

Events are up this Saturday, and look out for ways to get to know candidates.

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Sep 9 • 3:15 PM EDT • Business • pressherald.com
iPhone 18 Pro battery life compared to iPhone Duo and iPhone 17 Pro

Apple has just announced the new flagship iPhone lineup, featuring iPhone 18 Pro and iPhone Duo. One of the biggest...

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Sep 9 • 3:10 PM EDT • Technology • 9to5mac.com
Shooting to the top with a new form factor? - Samsung Galaxy Z Fold8 review

Samsung Galaxy Z Fold8 review: How does Samsung’s new foldable smartphone perform in everyday life? We evaluate the display, performance, camera, battery, and usability, and reveal exactly who the Fold8 is for—as well as where this foldable flagship still has work to do.

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Sep 9 • 2:54 PM EDT • Technology • notebookcheck.net
Kinsman Road Appearance Deters New Businesses

Newbury Township officials debated how to address the multitude of landscaping businesses along state Route 87 during the Sept. 2 trustees meeting. Newbury Township Trustees agreed they do not plan to force out the more than a dozen landscaping businesses already established along the corridor. However, they said they would like to see some improve

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Sep 9 • 2:38 PM EDT • Business • geaugamapleleaf.com
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The Apple Watch Ultra 4 Is an Even Better Heart Health Companion

Apple's high-end smartwatch also comes with the new internals of the Apple Watch Series 12 and even longer battery life.

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Sep 9 • 2:08 PM EDT • Health • gizmodo.com
Apple Watch Ultra 4 Comes With Better Battery And Upgraded Health Tracking

The Watch Ultra 4 isn't a major redesign, but does come with some notable improvements.

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Sep 9 • 2:02 PM EDT • Health • engadget.com
Apple Announces Apple Watch Series 12 With S11 Chip, Upgraded Health Sensors and Ceramic Models

Apple today announced the Apple Watch Ultra 4, featuring a new S11 chip, a redesigned health sensing system, and a larger battery that Apple says delivers two days of battery life. With improved power efficiency, Ultra 4 offers up to 18 hours of workout tracking with full GPS and heart rate monitoring, or 45 hours in its maximum extended workout mode. It comes in Black and Natural titanium, alongside new band colors and a new titanium Hermès band.

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Sep 9 • 1:42 PM EDT • Health • macrumors.com
iPhone 18 Pro and 18 Pro Max Both Have Crazy Battery Life

No regular iPhone 18 this year. Just two Pro models.

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Sep 9 • 1:23 PM EDT • Technology • gizmodo.com
South Tampa fire damages 4 businesses, owners face long recovery

A batch of businesses in South Tampa are on a long road to recovery after a fire.

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Sep 9 • 1:19 PM EDT • Business • fox13news.com
Laredo College offers free small business incubator workshop

Laredo College is offering a free online small business incubator for people with a business idea they want to launch.

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Sep 9 • 12:04 PM EDT • Business • kgns.tv
Canada's trade arsenal packs US political punch

To combat tariffs imposed by his country's hulking southern neighbor, ​Prime Minister Mark Carney ​is using asymmetric warfare. Retaliatory ⁠15% to 50% duties hit ​only $20 bln of goods. Tight ​US elections in border states, however, turn the sums into a powerful ​super PAC of sorts.

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Sep 9 • 11:59 AM EDT • Politics • reuters.com
Rabies testing concerns prompt investigation from Minnesota health officials

The Minnesota Department of Health is searching for customers of a Twin Cities company that it suspects has not been consistently submitting rabies tests for testing.

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Sep 9 • 11:37 AM EDT • Health • fox9.com
Seahawks Reveal 'Aggressive Timetable' For Zach Charbonnet's Return

Charbonnet is expected to miss time this season, but how much is up for debate.

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Sep 9 • 10:44 AM EDT • Sports • sports.yahoo.com
Firefighters battle early morning fire at Richland business

RICHLAND, Wash. - The 7-11 convenience store off Duportail and Wright Avenue in Richland is closed after it was damaged in an early morning fire Wednesday.The call for help came in just before a.m. When firefighters arrived, they saw heavy smoke coming from the building attached to the 7-11 and could see flames inside.Several fire crews responded to the area and a ladder truck was used to attack the fire from above. Richland police also arrived on scene to shut down streets so fire crews could work in the tight space. They also helped with people living close to the fire get out safely.Firefighters were able to get the fire under control but it continued to flare up and crews were finally released from the scene just before 6 a.m. A crew remained on the scene to continue checking the area. Fire investigators are also at the scene.The 7-11 remains closed until further notice after the building was heavily damaged by smoke and water. The building attached to it was destroyed.The cause of the fire has not yet been released. Injuries are also unknown. We are gathering more information at this time.COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.

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Sep 9 • 10:41 AM EDT • Business • applevalleynewsnow.com
Inside the AfD

"Inside the AfD" looks behind the respectable facade of the Alternative for Germany political party. Insiders reveal the tough tactics used by the right-wing populists to combat criticism.

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Sep 9 • 10:07 AM EDT • Politics • dw.com
Bruce Willis’ wife says he’s still ‘very present’ in health update amid dementia battle: ‘Learned to adapt’ (exclusive)

EW has an exclusive look inside Emma Heming Willis’ life with Willis, who still has “beautiful moments of joy and connection” amid “terrible” diagnosis.

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Sep 9 • 10:00 AM EDT • Entertainment • yahoo.com
Bucs $14M Addition Expected to Have ‘Prominent’ Role

One of the tougher fantasy football backfields to decide is the Tampa Bay Buccaneers. While many will be debating between Bucky Irving and Kenneth Gainwell as the top option in fantasy, Greg Auman of Fox Sports weighed in with a strong case for Gainwell. Auman noted that Zac Robinson has a chance to significantly improve […] The post Bucs $14M Addition Expected to Have ‘Prominent’ Role appeared first on HEAVY.

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Sep 9 • 9:59 AM EDT • Sports • sports.yahoo.com
Webinar: The Massive Scale of GLP-1s: Evolving Health, Healthcare and Markets

Watch this discussion on how GLP-1 drugs for obesity are changing the shape of U.S. healthcare. From direct-to-consumer portals to pharmacy deals, how these drugs reach patients is changing—and leading to debates over pricing and coverage. Learn how your company can be both patient-forward while also maximizing revenue in this unique environment.

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Sep 9 • 9:56 AM EDT • Health • biospace.com
Oregon Democrats seek to calm voters’ election uncertainties

Oregon Democrats express faith in the upcoming vote-by-mail election despite ongoing legal battles over President Donald Trump's attempt to restrict mail ballot delivery.

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Sep 9 • 9:54 AM EDT • Politics • klcc.org
How Aaron Judge’s return affects the Yankees’ lineup construction

We take a look at how the Yanks lined up this season to see how they might approach the batting order going forward.

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Sep 9 • 8:30 AM EDT • Sports • sports.yahoo.com
Scientists find a bone-building switch that could fight osteoporosis

An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.

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Sep 9 • 8:00 AM EDT • Science • sciencedaily.com
2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge

2une In Previews: LASM's 41st annual gala brings live entertainment, open bars, new art to Baton Rouge

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Sep 9 • 8:00 AM EDT • Entertainment • wbrz.com
Lease dispute between Wegmans, Cary landlord heats up

A federal judge ordered Wegmans to pay $625,000 into court while the grocer battles its Cary landlord over an unbuilt store at Fenton.

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Sep 9 • 7:18 AM EDT • Business • bizjournals.com
An embattled Donald Trump is increasingly using sports as prop

Sports is the rare topic in which the president has succeeded in shifting the conversation to his preferred terms

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Sep 9 • 5:00 AM EDT • Sports • theguardian.com
Slime Molds and a double Ig Nobel Prize winner and a big, great science adventure

” ‘This is dangerous’: slime moulds and the bitter debate over the nature of intelligence — Scientists are battling over whether supposedly simple organisms should be considered ‘intelligent’…

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Sep 9 • 3:24 AM EDT • Science • improbable.com
Lane Kiffin and Livvy Dunne Just Made LSU Cool Again

I’m not saying Lane Kiffin is the most entertaining hire LSU has made in years. I’m just saying Livvy Dunne is suddenly back around LSU football. Coincidence? Absolutely. But let me have my fun. Dunne returned to Baton Rouge for LSU’s season opener against Clemson, watched the Tigers absolutely demolish the Tigers 51-10 and showed…

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Sep 9 • 3:20 AM EDT • Sports • sports.yahoo.com
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Belgium battle could be a blessing

It is a new chapter for Aston Villa and, against Club Brugge, they turned the page. A first win of the season, albeit more nervy than anticipated, lit the spark for Unai Emery's side. The visitors were in a commanding and deserved position at half-time, John McGinn's opener making him the club's all-time record European goalscorer with 12.

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Sep 9 • 3:19 AM EDT • Sports • sports.yahoo.com
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Baton Rouge General's Health Tip of the Week: Another sugar substitute raises heart concerns

Sponsored by Baton Rouge General Cutting back on sugar? Take a peek at the ingredient label before reaching for a sugar-free treat. Recent research has raised questions about xylitol, a sugar alcohol found in products like gum, candy and baked goods. Higher blood levels of xylitol were linked to a greater risk of heart attack […]

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Sep 9 • 2:01 AM EDT • Health • businessreport.com
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Five Plays: Ole Miss First Quarter

Louisville went down to Nashville and battled Ole Miss to the final second on the clock. There were a lot of questions that the Cards needed to answer quickly, with the main one being how Lincoln Kienholz would play in his first career start. But UofL came out with a great plan, and they took […]

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Sep 8 • 10:36 PM EDT • Sports • sports.yahoo.com
Baylor finds confidence and belief despite loss to Auburn

WACO, Texas (FOX 44) — Baylor may have lost the battle on the scoreboard Saturday, but the Bears believe they gained something just as important in Atlanta: confidence. Despite a loss to Auburn, Baylor players said the game showed the team’s growing chemistry, physicality and belief heading into the rest of the season. Fifth-year cornerback […]

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Sep 8 • 10:05 PM EDT • Sports • sports.yahoo.com
Gen Z conservative influencers bring campus debates to Valley colleges, drawing online audiences

At a table on the campus of Mesa Community College, microphones are on, cameras are rolling and students are lining up to debate everything from politics and religion to culture and public policy.

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Sep 8 • 9:30 PM EDT • Politics • abc15.com
Detroit Lions Receive Several Major Updates Ahead of Week 1

The Detroit Lions received several major updates ahead of Week 1, including encouraging injury news, a key roster decision, and an intriguing offensive line battle.

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Sep 8 • 9:27 PM EDT • Sports • sports.yahoo.com
Marlins' Brian Navarreto Finding Value Beyond Bat

Miami’s veteran backstop has endured a difficult offensive year while continuing to provide the Marlins with dependable work behind the plate and timely contributions.

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Sep 8 • 8:48 PM EDT • Sports • sports.yahoo.com
Tiafoe escapes Michelsen to reach US Open semi-finals

Frances Tiafoe rallied from two sets down -- and 3-0 down in the fifth set -- to edge 22-year-old Alex Michelsen 5-7, 3-6, 7-5, 6-3, 7-6 (10/6) and reach the US Open semi-finals on Tuesday.But in a match of swinging momentum shifts, Tiafoe battled back from 5-3 down in the third set and recovered an early break in the fifth to reach his third US Open semi-final in five years.

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Sep 8 • 8:23 PM EDT • Sports • sports.yahoo.com
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SteelSeries Brings Its Outstanding Infinite Battery System to Controllers With the Aeon Pro for Xbox and PC, But Is It Worth the Sky-High Price Tag?

The SteelSeries Aeon Pro packs in just about every "pro" feature you could ask for in a controller, with Hall-effect thumbsticks, tactile switch buttons, adjustable triggers, and the company's outstanding hot-swappable battery system.

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Sep 8 • 7:18 PM EDT • Technology • ign.com
Jamison Battle’s Preparation Could Earn Him More Raptors Minutes

Toronto has a reserve shooter worth examining closely, especially when his limited opportunities arrive without much warning.

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Sep 8 • 5:32 PM EDT • Sports • sports.yahoo.com
Newcastle battle past Millwall to reach League Cup fourth round

Newcastle battled into the League Cup fourth round as Joe Willock's late goal sealed a bruising 1-0 win against Millwall on Tuesday.But Newcastle survived to keep alive their bid to win the League Cup for a second time in three years.

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Sep 8 • 5:30 PM EDT • Sports • sports.yahoo.com
Senate Set to Vote to Begin Debate on Protect College Sports Act

Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.

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Sep 8 • 4:36 PM EDT • Sports • akingump.com
49ers catch massive break for Week 1 battle vs. Rams

The 49ers are taking on the Rams in Week 1 of the 2026 season, but their division rivals won't have one of their best players for the matchup.

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Sep 8 • 4:07 PM EDT • Sports • sports.yahoo.com
Yankees At-Bat of the Week: Austin Wells (9/2)

Wells’ bat has come alive right when the Yankees need it.

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Sep 8 • 4:00 PM EDT • Sports • sports.yahoo.com
WBA Foundation cancels 2026 Wisconsin gubernatorial debate

MADISON (WKOW) — The WBA Foundation's televised 2026 gubernatorial debate, originally scheduled for Oct. 9, has been canceled.

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Sep 8 • 4:00 PM EDT • Politics • wxow.com
Group of bikini baristas win nearly $2M in legal battle

Former bikini baristas at five coffee stands in the Puget Sound region say they were paid below minimum wage and forced to turn over earnings to keep up with strict

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Sep 8 • 3:43 PM EDT • Entertainment • thederrick.com
Arsenal 2-1 Chelsea win changes the transfer-window conversation

Arsenal’s win over Chelsea put the transfer debate into perspective, with the champions showing why their existing squad may already be strong enough.Photo by Ryan Pierse/Getty ImagesI don’t know ...

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Sep 8 • 3:05 PM EDT • Sports • sports.yahoo.com
Florida business owner arrested after employees find hidden camera in bathroom: sheriff

NEW SMYRNA BEACH, Fla. (WFLA) — A Florida man was arrested on Monday after it was revealed that he hid a small camera inside an electrical outlet in the bathroom of his business. Donald Hemphill, 5…

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Sep 8 • 2:39 PM EDT • Business • wfla.com
Louisiana’s marine research collaboration becomes a political battleground

A select group of Louisiana higher ed leaders are discussing what to do with the state's marine research consortium

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Sep 8 • 2:21 PM EDT • Politics • lailluminator.com
Business district battle in Back Bay Power Play

Back Bay's biggest landlord steps up its fight against a business improvement district for the neighborhood.

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Sep 8 • 1:57 PM EDT • Business • bostonglobe.com
After RFK visit, board members seek new policy to keep politics out of schools

Board members look to update rules about what level of politicking should be allowed in schools.

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Sep 8 • 1:54 PM EDT • Politics • tampabaybeacons.com
Republicans were confident about keeping the Senate. Now the battle is wide open

Republicans appeared to have a firm grip on the majority at the start of the 2026 election cycle. But Democrats are now competing in states that once seemed well beyond their reach.

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Sep 8 • 1:41 PM EDT • Politics • pbs.org
Pritzker, Eyeing 2028, to Help Midterm Democrats With a $20 Million Group

JB Pritzker, the billionaire governor of Illinois, is continuing to expand his national footprint, this time by using a new group to target Republicans in battleground races.

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Sep 8 • 1:20 PM EDT • Politics • nytimes.com
The debate on whether WEC prioritised 'entertainment' over 'sport' in Austin

WEC hosted its Austin round last weekend, but did the series go too far in its pursuit of an entertaining race?

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Sep 8 • 12:28 PM EDT • Entertainment • autosport.com
WBA Foundation cancels 2026 Wisconsin gubernatorial debate

MADISON (WKOW) — The WBA Foundation's televised 2026 gubernatorial debate, originally scheduled for Oct. 9, has been canceled.

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Sep 8 • 12:27 PM EDT • Politics • wkow.com
The official sequel to The Ur-Quan Masters releases its free demo today

Blast your opponents in 1v1 arcade space battles like it's 1992 all over again.

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Sep 8 • 12:05 PM EDT • Technology • arstechnica.com
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate

The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]

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Sep 8 • 12:04 PM EDT • Politics • combatantisemitism.org
Hidden camera found in bathroom of Volusia County pet daycare business, owner arrested, deputies say

The owner of a pet daycare and boarding facility in Volusia County has been arrested after a hidden camera was found in the facility's bathroom, according to the Volusia County Sheriff's Office.

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Sep 8 • 12:00 PM EDT • Business • fox35orlando.com
Former MSU Interim AD Jon Palumbo Heading to Kentucky

The Spartans’ leadership exodus continues as another top executive reunites with J Batt in Lexington, leaving East Lansing to navigate a shifting front office after months of transition.

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Sep 8 • 11:57 AM EDT • Sports • sports.yahoo.com
Review: SteelSeries Aeon Pro: The Infinite Battery Life, Dual-System Xbox and PC Controller Impresses, Despite Its High Price

Borrowing the best ideas from the firm's Arctis Nova Pro headset lineup.

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Sep 8 • 11:30 AM EDT • Technology • digitalfoundry.net
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say

He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.

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Sep 8 • 11:10 AM EDT • Business • wftv.com
The US wants a stronger battery supply chain. China has a decades-long head start

The Trump administration is attempting to strengthen the U.S. battery supply chain and reduce the country’s dependence on China, but analysts and industry executives say current funding is small compared with what would be needed to substantially challenge China’s dominance, CNBC reports. In August 2026, the Department of Energy awarded $500 million to seven companies […]

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Sep 8 • 10:57 AM EDT • Business • businessreport.com
Rock Creek Entertainment District in Norman faces another legal battle

A judge will hear arguments on Tuesday as the legal battle over the $1.1 billion Rock Creek Entertainment District in Norman heads back to court.

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Sep 8 • 10:53 AM EDT • Entertainment • koco.com
UnitedHealth’s Democrat investment, and surprise billing bloat debate

UnitedHealth execs shower a top Democrats with cash, and the No Surprises Act debate heats up.

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Sep 8 • 10:51 AM EDT • Health • statnews.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Permits issued for Simple Joe Cafe expansion, $1.2 million Magnolia Wood home

Here is a list of commercial and residential building permits issued by East Baton Rouge Parish Government from Aug. 31-Sept. 4.

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Sep 8 • 10:00 AM EDT • Business • theadvocate.com
Battle of 224 headlines Friday’s Game of the Week

Around here, the Battle for 224 is one of the greatest rivalry games on the calendar - Poland versus Canfield.

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Sep 8 • 9:06 AM EDT • Sports • sports.yahoo.com
Explainer: Why Air India's funding call has come under political scrutiny in Singapore

Air India's request for about $1.5 billion in funds from its owners — Tata Sons and Singapore Airlines — has sparked a debate in Singapore over state investor Temasek's exposure to the Indian ​carrier.

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Sep 8 • 9:05 AM EDT • Politics • reuters.com
Six decades of politics (but little government)

The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share

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Sep 8 • 9:03 AM EDT • Politics • smotus.substack.com
CNN to host California gubernatorial debate ahead of November election

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Sep 8 • 9:01 AM EDT • Politics • kten.com
CNN to host California gubernatorial debate ahead of November election

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Sep 8 • 9:01 AM EDT • Politics • cnn.com
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Sep 8 • 8:32 AM EDT • Sports • sports.yahoo.com
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Sep 8 • 8:30 AM EDT • Sports • sports.yahoo.com
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Sep 8 • 8:16 AM EDT • Entertainment • seattletimes.com
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan

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Sep 8 • 8:15 AM EDT • Entertainment • audacy.com
Ancient Roman fresco and mosaic featuring maritime city unveiled at newly restored Baths of Trajan

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Sep 8 • 8:15 AM EDT • Entertainment • wsls.com
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Sep 8 • 8:00 AM EDT • Science • news.clemson.edu
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Sep 8 • 7:52 AM EDT • Sports • sports.yahoo.com
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Sep 8 • 7:33 AM EDT • Business • foxbusiness.com
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Sep 8 • 7:00 AM EDT • Sports • sports.yahoo.com
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Sep 8 • 7:00 AM EDT • Politics • sfchronicle.com
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Sep 8 • 6:55 AM EDT • Business • wtvbam.com
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Sep 8 • 5:45 AM EDT • Entertainment • recorderonline.com
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Sep 8 • 5:00 AM EDT • Politics • charlotteobserver.com
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Sep 8 • 5:00 AM EDT • Politics • washingtonpost.com
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Sep 8 • 4:47 AM EDT • Sports • sports.yahoo.com
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Sep 8 • 4:45 AM EDT • Health • battlecreekenquirer.com
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Sep 8 • 4:40 AM EDT • Science • timesofindia.indiatimes.com
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Sep 8 • 4:30 AM EDT • Health • statnews.com
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Sep 7 • 11:59 PM EDT • Sports • sports.yahoo.com
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Sep 7 • 11:52 PM EDT • Business • wdbj7.com
X-Men Reboot’s Wild 4-Movie Comparison Includes Batman V Superman

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Sep 7 • 11:41 PM EDT • Entertainment • yahoo.com
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Sep 7 • 11:00 PM EDT • Technology • gsmarena.com
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Sep 7 • 10:37 PM EDT • Sports • sports.yahoo.com
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Sep 7 • 9:38 PM EDT • Sports • sports.yahoo.com
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Sep 7 • 9:18 PM EDT • Sports • sports.yahoo.com
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Sep 7 • 8:00 PM EDT • Technology • warhammer-community.com
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Sep 7 • 6:32 PM EDT • Science • elizabethton.com
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Sep 7 • 6:05 PM EDT • Sports • sports.yahoo.com