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AI Agents Are a Threat to Travel Businesses. Airbnb Could Still Be a Winner.
For the lodging platform’s stock to thrive in the age of bots, it has to turn repeat customers into loyal ones.
Navan Selected by Investec to Modernize Global Travel Program
PALO ALTO, Calif.--(BUSINESS WIRE)--Oct 12, 2026--
Britney Spears claims she worked 'seven days a week for 15 years'
Britney Spears has revealed she travelled for the first time on her own around six years ago.
Miami’s Offense Could Potentially Run Over Seminoles Defense
In two road losses this season, Florida State has given up 1,104 total yards, 644 rushing yards, and 94 points. The Seminoles travel to Miami to take on the Hurricanes, who run the No. 1 offense in college football.
‘The Vote Is Sacred’: National tour stops in Cleveland to encourage voter participation
Faith leaders travel 9,000 miles to encourage voter participation as Ohioans head to the polls for early voting.
Republicans want Abdul El-Sayed to be the main character of the midterms. He's happy to oblige
Michigan’s Senate race has become a battle over Democratic nominee Abdul El-Sayed. Republicans portray him as a dangerous radical; El-Sayed responds by traveling across Michigan and meeting voters.
Shakira and Gerard Piqué Appear in Court Over Their Sons' Flight Schedules
The singer and her ex appeared in court over how their sons travel between Miami and Spain.
7 ways science is changing the Arctic expedition experience
As travellers seek more meaningful experiences, HX highlights seven ways that science-led travel is changing the Arctic expedition experience.
Ken Paxton’s security for travel cost taxpayers millions. Just 1 in 6 trips had stated business
Records show the Texas attorney general has taken nearly 1,000 trips during his tenure, costing $3.3 million
Sassuolo vs AC Milan – Match preview and team news
AC Milan travels to the MAPEI Stadium for their next Serie A encounter on Sunday against Sassuolo as they look to enter the top four of the league table.Sassuolo vs AC Milan – Match preview and tea...
Como vs AS Roma – Match preview and team news
AS Roma travels away from home as they face Como in their next Serie A encounter on Sunday as they look to take the top spot back from Inter Milan.Como vs AS Roma – Match preview and team newsDate:...
I flew from the US to Turkey for a hair transplant before my wedding
Nicole Ethridge was self-conscious about her alopecia. She traveled from the US to Turkey to have a hair transplant. A bride-to-be, she is delighted.
Jim and Marilyn Simons lent their 68-metre superyacht to ocean scientists; an $80,000 system tested whether luxury vessels could help validate satellite data
Superyachts are usually associated with luxury travel, but the 68-metre Archimedes, owned by Jim and Marilyn Simons at the time of the research, also became a platform for marine science. During several deployments between 2018 and 2020, an autonomous measurement system aboard the yacht collected ocean-colour observations at a range of locations, including remote regions such as the Antarctic Peninsula.
Erie County Department of Health reports potential diphtheria exposure in West Seneca schools
BUFFALO, N.Y. (WIVB) — The Erie County Department of Health has confirmed a travel-related case of bacterial illness diphtheria, with schools in the West Seneca Central School District being identified as potential exposure sites. According to the district, notifications have been sent to families at Clinton Primary, Northwood Elementary, Winchester-Potters Elementary & East Middle School. […]
Chicago Bears @ Green Bay Packers: Week 5 Players to Watch
Take a look at @BryanOrenchuk’s players to watch for Green Bay as Chicago travels to Lambeau Field for the 214th meeting between the two franchises.
Everton's Trip To Hull: The Opposition View
Everton travel to Hull City in the Premier League on Sunday as David Moyes' side look to continue their unbeaten run.
📸 Neuer's unbelievable howler after just 8 seconds 😱
Ouch.This Saturday afternoon, Bayern Munich travel to Augsburg for Matchday 5 of the Bundesliga. Vincent Kompany's players made the worst possible start to this Bavarian derby, conceding the opening g...
Maresca: Man City players can shut out controversy against Liverpool
Enzo Maresca has no concerns about his players' mentality as Manchester City brace themselves for a hostile reception at Liverpool. City travel to Anfield on Sunday for their first match since it was announced the club had been found guilty of breaching the Premier League's financial regulations.
6 Hobbies That Can Become Startup Ideas, From Photography to Travel
Your next business may be hiding in what you already do for fun. These hobbies can produce practical startup ideas with growing markets.
Watch Motherwell v Celtic LIVE on CelticPlayer
The Celts are back after the international break! The Bhoys travel to North Lanarkshire to take on Motherwell in the Scottish Premiership tomorrow (October 11). The Hoops sit top of the table, and it�...
Colorado Politics Calendar Oct. 12-18
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
Maple Leafs Announce Major Player Absence Ahead of Avalanche Showdown
The Toronto Maple Leafs revealed that forward John Tavares will be unavailable on Saturday as the Maple Leafs gear up to face their toughest test of the season against the Colorado Avalanche.Maple Leafs head coach Jim Hiller told Travelling Reports that Tavares had headed back to Toronto as the Tavares family welcomed their newest son, […] The post Maple Leafs Announce Major Player Absence Ahead of Avalanche Showdown appeared first on HEAVY.
Kenya prepared for Ebola. It still slipped through — a warning of wider cross-border spread
Kenya had spent months preparing for Ebola, one of the world’s deadliest viral diseases, screening hundreds of thousands of travelers and training nearly 5,000 health workers in case it crossed the borders.
Hotel executive checks in on the blows to Hawaiʻi's tourist business
Jerry Gibson, President of the Hawaiʻi Hotel Alliance, discusses rising travel costs and troubling tourism numbers.
Trump rally brings road closures, business prep to Clarksville
President Trump is scheduled to fly into Fort Campbell on Saturday, Oct. 10, for a midterm rally. His motorcade will travel across town to the F&M Bank Arena near the Austin Peay campus.
Ex-Saints QB Suddenly Released by Eagles
In a successful and well-traveled NFL career, Andy Dalton had a stop with the New Orleans Saints. It wasn’t the most memorable or the longest, but it was substantial time on the field for “The Red Rifle” with the Saints. It came to mind again on Friday, when the Philadelphia Eagles surprisingly released Dalton after […] The post Ex-Saints QB Suddenly Released by Eagles appeared first on HEAVY.
Dept. of Health confirms eighth travel-related dengue virus case on Oahu
Of the eight dengue cases reported in Hawaii in 2026, all have involved travel to Pacific Island countries and territories.
Wake Forest vs NC State Preview
As Jake Dickert tries to put his own imprint on Wake Forest football, there is a major opportunity on Saturday. The Demon Deacons travel to Raleigh to face NC State, a school that has given Wake plenty of trouble in recent years. Wake comes into the game at 4-1 overall and 2-1 in ACC play. …
I Flew in Condor Business Class From NYC to Germany: Is it Worth the Upgrade?
Traveler editor Charlie Hobbs takes flight with Condor, the Frankfurt-based carrier known for its relatively affordable transatlantic fares.
Travel Health Insurance Requirement Implemented
As of October 6, 2026, all travelers to Kenya must obtain travel health insurance through the government-sanctioned provider prior to entry and must present proof of coverage upon arrival. The Electronic Travel Authorisation (ETA) portal (for ETA-eligible nationals) and the eCitizen portal (for non-ETA-eligible nationals) have been updated with this requirement. The insurance costs approximately USD 44 and is valid for one year, including for repeat trips to Kenya during the insurance policy's validity period. Previously, travelers could rely on private or employer-provided health insurance and did not need to provide proof of coverage before entering the country. This change will not affect the above applicants' processing times. However, travelers should obtain the required insurance before traveling to avoid delays or bars to entry. Notably, Tanzania recently adopted a similar mandatory inbound travel insurance requirement, potentially signaling an emerging trend in the East African region.
Mitoma Update: Brighton Confirmed Team News for Sunderland
Fabian Hürzeler navigates a persistent injury crisis as the Seagulls travel north, missing key stars like Kaoru Mitoma while facing a resilient, counter-attacking Sunderland side.
In brief: 'Stick' season 2 trailer and more
Bill Murray stars in the official trailer for A Course Called Ireland. The six-part documentary series premieres on Paramount+ on Oct. 25. The show follows Murray and his friends as they travel across the island to explore Northern Ireland and the Republic of Ireland's best fairways ...The Die Hard films are getting a brand-new home media release. All five of the movies will be released on physical media in 4K Ultra HD on Dec. 1. Bruce Willis stars as John McClane in all of the Die Hard films. The original movie finds the New York City policeman taking on terrorists after he flies to Los Angeles to be with his estranged wife and two children on Christmas ... TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); The trailer for Stick season 2 is here. Owen Wilson stars as the talented golfer who strives for second chance in the sophomore season. Peter Dager, Timothy Olyphant, Rhea Seehorn, Marc Maron, John Higgins and Billy Zane also make up the cast of the new season. The Apple TV series premieres its first two episodes on Nov. 4. A new episode drops weekly every Wednesday that follows until the season finale airs on Dec. 30 ...Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.
Fake scenes, real politics: Republican candidates have embraced AI.
From time-traveling politicians to altered Bible verses, Texas GOP ads depict scenes that never happened. Democrats steer clear.
Ken Paxton took nearly 1,000 trips with state-funded security
The Texas attorney general’s use of a taxpayer-funded travel security detail stands out when compared with his predecessor and other state officials, our analysis found.
Eagles abroad: London matchup fuels big business for fan travel companies
The Eagles' trip to London means big business for travel companies, pubs and local businesses.
Trump-tied firm helped organize political advisers’ Balkans travel
Chris LaCivita and James Blair’s trip to the Balkans occurred after former Trump campaign adviser Alex Garcia initially reached out, multiple people told Semafor.
Business travel is turning short trips into tax and visa traps
Work from anywhere arrangements are exposing Australian employers to visa, tax and payroll obligations HR teams often miss
FCM Travel Launches Proactive Analytics Tool
New capability said to monitor travel programs around the clock
Boston Celtics Preseason: Four Stories to Watch vs. Cavaliers
The Celtics will play their first game since June on Thursday night when they travel to Cleveland.
Introducing Air Canada Embarq, a New Self-Serve Business Travel Platform for Canadian Small and Medium-Sized Enterprises
New Air Canada for Business platform helps companies manage, optimize and reward business travel from one convenient platformAir Canada partnered with ZS, a global management consulting and technology firm and Traverse, powered by ARC, to deliver the technology to support Air Canada EmbarqAir Canada is putting business travel management tools and benefits that have traditionally been used by large enterprise customers directly in the hands of Canadian small and medium-sized businesses and non-pr
Chaminade at Cardinal Newman football has Open Division ramifications
Chaminade-Madonna travels to Cardinal Newman in a rematch of the 2025 Class 1A state title game, which Cardinal Newman won 17-14.
Dodgers, Brewers meet again in second straight NLCS
If the Dodgers are going get back to the World Series to finish off their third consecutive championship, they’ll have to travel the same path as in 2025 to complete their trek through the National League. The Dodgers will play the Milwaukee Brewers in the NLCS beginning Sunday night, October 11 at American Family Field […]
Nebraska soccer prepares for Maryland and Rutgers
After a gauntlet of ranked matches, Nebraska will travel eastward to face Maryland and Rutgers. The Terrapins and Scarlet Knights will pose a challenge to the Huskers this weekend.
2027 NFL Draft Prospects to Watch in Week 6
As we approach the mid-season point, we can tick another group of prospects off the list of those yet to be tested. Georgia travels to Alabama in the big game of Week 6. Who should you watch in this one, and the other big NFL Draft matchups of Week 6? 2027 NFL Draft Prospects to …
GLP-1s: the science behind today’s weight-loss drugs
The medicines reshaping obesity treatment grew out of research into how the body handles a meal. Long before weekly weight-loss injections became familiar, scientists were studying signals that travel from the intestine to the pancreas, helping it release insulin when nutrients arrive.
Data centers in Ohio are redrawing political battle lines
In Southwest Ohio, planned data centers are fueling intense local backlash. NBC News’ Ryan Nobles traveled to a Trump stronghold where the debate is shifting political allegiances and could swing the balance of power in Congress come November.
For the love of the game: URI students travel to Ireland to cover, experience international sporting community
KINGSTON, R.I. – Oct. 7, 2026 – Nine University of Rhode Island Harrington School of Communication and Media students spent two weeks in Ireland this summer exploring the country’s sports culture while putting their reporting and storytelling skills to work. That experience left a profound impact on the students that went well beyond their reporting […]
CDC sees low plague risk, monitors Siberia arrivals after worker death, director says
Centers for Disease Control and Prevention Director Erica Schwartz said on Wednesday the risk to the US from an unconfirmed pneumonic plague case in Siberia was extremely low, but the agency was prepared to monitor and screen travelers.
NASA Releases Artemis II Lunar Science Data, Images
NASA’s Artemis II crew traveled around the Moon and back and, along the way, captured stunning imagery and scientific observations of our nearest neighbor.
Why ‘Wives’ is relevant to the times
Parvesh Cheena, actor in Jaclyn Backhaus’ play WIVES, at East West Players, co-produced with Hypokrit Live Arts. Photo by Daniel Antonio Vallejo. At a time when marginalized voices are changing the national conversation, Jaclyn Backhaus’ play Wives, featuring a South Asian American cast, is both relevant and funny. “This play offers its actors the opportunity to time travel, to play many…
Kristaps Porzingis still not around Warriors as he deals with “concerning” health condition
Kristaps Porzingis did not travel with the Warriors to Hawaii for training camp, was not at Tuesday’s preseason game at Chase Center
Central Florida students ‘scout’ out coveted nuclear science merit bad
With the help of dedicated Airmen from the Air Force Technical Applications Center here, 89 inspired scouts from across Central Florida traveled to Patrick SFB Sept. 19 to earn the coveted Nuclear
Pixar exhibit brings movie magic to Frost Science
Buzz Lightyear may have doubts about humans and space travel, but when it comes to bringing Pixar characters to life, filmmakers take technology to infinity and beyond.
Browns announce unofficial depth chart for Week 5 vs. the Jets
The Browns will travel to East Rutherford, N.J., to face the Jets at MetLife Stadium on Oct. 11 in Week 5
'If Abdul can win in Michigan, anyone can win anywhere': Alexandria Ocasio-Cortez outlines stakes for progressives at NYC fundraiser
Ocasio-Cortez is traveling across the country as she considers her political future and potential bids for higher office in 2028.
Health Alert – U.S. Embassy Moscow, Russia (October 6, 2026)
Health Alert – U.S. Embassy Moscow, Russia (October 5, 2026) Location: Irkutsk, Russia Event: The U.S. Embassy is aware of press reports from the Irkutsk region of suspected pneumonic plague resulting in the death of an individual and of associated quarantine measures in, and closures of, hospitals in Irkutsk. We continue to track the situation closely. The U.S. government has limited ability to help U.S. citizens in Russia, especially outside of Moscow. U.S. government personnel may face additional restrictions for personal and official travel to specific regions due to health and security concerns. The State Department’s Level 4 Travel Advisory (Do Not Travel) for Russia remains in place and states U.S. citizens currently in Russia should depart immediately. U.S. citizens planning travel to Russia are again strongly advised not to travel to Russia due to risk of wrongful detention and security concerns. Actions to Take: S. citizens in the area should follow the guidance of local health authorities, avoid affected facilities, and seek medical care promptly if they develop fever or respiratory symptoms. Visit the CDC Page on Plague for additional information about the disease. Visit the CDC Travelers’ Health Page for Russia for country-specific health updates. Monitor your health for 14 days following travel if you traveled to an area experiencing the outbreak. Review the S. Embassy country page for general health information. Refer to the Embassy’s list of medical providers. Check with your travel insurance provider about medical evacuation options should you fall ill while overseas. Have a plan to depart in an emergency that does not depend on U.S. government help. Monitor local media for updates. Be prepared to adjust your plans. Enroll in the Smart Traveler Enrollment Program(STEP) to receive health and security updates. Assistance: U.S. Embassy Moscow, Russia +7 495 728-5577 MoscowACS@state.gov U.S. Embassy Moscow web page State Department – Consular Affairs (+001) 888-407-4747 or (+001) 202-501-4444 Russia Country Information Follow us on Facebook and Twitter State Department – Consular Affairs 1-888-407-4747 or 1-202-501-4444
All the New Science Fiction Books Arriving in October 2026
This October, travel to Pompeii with a slime mold, get into some time travel shenanigans, head to Paradise, and more…
Anker’s 100W universal charger is a great travel gadget for $64
Keep your devices charged up during your travels.
GBTA Foundation Names 2026 WINiT Top 50
Honor recognizes women in business travel and meetings
How hunger is devastating Yemen’s children
Al Jazeera travels to Yemen's displacement camps to measure the toll of malnutrition on the country's children.
Musical residencies: Business is booming, but who pays the most for pop stars playing in Europe?
Musical residencies are on the rise in Europe for major pop stars, but costs are increasingly being heaped upon audiences with travel, accommodation and extras pushing up ticket prices, according to S...
SnakePit Post-season GDT, #6
Probably safe to say that both results in the National League Division Series went in the way most readers of the SnakePit wanted, with the Padres and Dodgers both losing. The NL gets a travel day today, as the series relocate to San Diego and Atlanta respectively, before resuming on Wednesday. So, today, it’s the […]
Tottenham’s International Returns For Manchester United Preparations
Tottenham’s internationals return in stages before Manchester United, leaving Roberto De Zerbi to balance training, travel and recovery at Hotspur Way.
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Now Open! APSA Teaching & Learning Conference Awards and Travel Grants | Deadline: November 16, 2026 -
Now Open! Apply for TLC Travel Grants & Awards Michael Brintnall Teaching and Learning Award APSA Award for Teaching Innovation | Travel Grants Deadline: November 16, 2026, 11:59PM ET Join political science teacher-scholars and students [...]
Bruno Guimaraes Details Heavy Brazil Workload Ahead of Arsenal Return
Bruno Guimaraes has revealed the amount of travelling Brazil faced during a demanding international window before his return to Arsenal.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
United Will Begin Selling Basic Fares for More Premium Products
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