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Iranian Academic Outlines Strategic Impacts of Confrontation with US, Israeli Regime

TEHRAN (Tasnim) – University professor Hamid Reza Moqaddamfar outlined 10 strategic consequences of Iran’s confrontation with the US and Israel, arguing that the conflict went beyond the failure of Washington and Tel Aviv to achieve their military objectives and challenged key pillars of US power.

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Sep 20 • 4:30 AM EDT • Politics • tasnimnews.ir
Braves News: Robert Suarez, division on the brink, more

Atlanta Braves news and notes from Saturday

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Sep 20 • 12:01 AM EDT • Sports • sports.yahoo.com
Guardians’ Jose Ramirez Regaining Form at Perfect Time

Jose Ramirez has come up with multiple big hits for the Cleveland Guardians over the last week.

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Sep 19 • 7:20 PM EDT • Sports • sports.yahoo.com
St. Louis Cardinals vs Washington Nationals Game Discussion Saturday Night

Only two more games for the Cardinals season at Busch Stadium. Saturday night, it’s game 2 of the weekend homestand vs the Washington Nationals. Michael McGreevy is the starter for the Cardinals while it’s LHP Andrew Alvarez for the Nationals. First pitch is scheduled for 6:15pm and the game broadcast will be available through Cardinals.tv.

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Sep 19 • 7:00 PM EDT • Sports • sports.yahoo.com
How Colorado’s last purple district could shape power at state Capitol

Pueblo's 2026 Colorado Senate District 3 race features Dana Charles and Aaron Gutierrez, with jobs, energy, fire recovery and Pueblo's political identity at stake.

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Sep 19 • 7:00 AM EDT • Politics • coloradopolitics.com
💥 Laporta: Some rivals get rezoned when in trouble...

Joan Laporta spoke at Barça’s assembly this morning and wanted to take a major swipe at his opponents. This is how Joan began his speech: “A club of Barça’s stature always faces major challeng...

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Sep 19 • 4:41 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-20%)
Ranger Suarez takes the bump in Tampa Bay

How low can that magic number go?!

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Sep 18 • 6:10 PM EDT • Sports • sports.yahoo.com
Gov. Pritzker Launches Illinois Reproductive Health Care Hub

New website centralizes resources for reproductive care in Illinois, connecting site visitors to medical providers, affordable care options, and helpful information

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Sep 18 • 3:30 PM EDT • Health • gov-pritzker-newsroom.prezly.com
Perez Hilton's friend launches GoFundMe for his children amid mental health treatment
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Sep 17 • 3:14 PM EDT • Health • yahoo.com
Stacy’s Streamers: Four Players to Start in Week 2

Stacy Perez highlights one player at each position who is worth streaming in Week 2.

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Sep 16 • 6:04 PM EDT • Sports • sports.yahoo.com
Perez Hilton's family addresses 'false reports' on the blogger

Perez Hilton's family is offering a health update and clearing up 'false reports' tied to the blogger's mental and physical condition after a violent mental health crisis unfolded on TikTok last month.

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Sep 15 • 8:14 PM EDT • Entertainment • latimes.com
Democrat rebels defy Jeffries to hand GOP critical win just before midterms

House Democrats Jared Golden and Marie Gluesenkamp Perez broke ranks to rescue a Republican rule vote, dealing a fresh blow to Hakeem Jeffries.

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Sep 15 • 6:13 PM EDT • Politics • foxnews.com
FOX Sports, Wilmer Valderrama's WV Alternative and NASCAR Studios announce 'Suárez,' set for Sept. 17 on FS1

Find out where you can tune in to the Suárez documentary on FOX Sports and made with NASCAR Studios and Wilmer Valderamma's WV Alternative.

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Sep 15 • 9:20 AM EDT • Sports • nascar.com
Chicago Cubs news

Pedro Ramirez’s solo blast gave the Cubs a 2-0 lead on the way to a 4-3 victory Saturday, giving the Cubs the series win over the Pirates.

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Sep 15 • 8:00 AM EDT • Sports • sports.yahoo.com
Perez Hilton's family shares new recovery update weeks after alarming livestream

Editor's Note: If you or someone you know may be experiencing a mental health crisis, contact the 988 Suicide & Crisis Lifeline by dialing or texting “988.”

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Sep 14 • 7:16 PM EDT • Entertainment • centraloregondaily.com
Perez Hilton Moved to Residential Treatment Facility 1 Month After Mental Health Crisis

One month after suffering a mental health episode on TikTok Live, Perez Hilton is out of the hospital. “After weeks in the hospital receiving treatment for his physical injuries, Perez entered a resid...

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Sep 14 • 4:28 PM EDT • Health • yahoo.com
Will Yordan Alvarez win Triple Crown? Astros slugger chases history
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Sep 14 • 2:17 PM EDT • Sports • sports.yahoo.com
🚨XIs in: clash of contrasts between Villarreal and Betis

Estadio de la Cerámica bears witness to a clash shaped by opposite realities in LaLiga EA Sports. Iñigo Pérez’s Villarreal come into it reeling after a heartbreaking 2-3 defeat to Deportivo La Co...

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Sep 14 • 1:43 PM EDT • Sports • sports.yahoo.com
Atlanta Braves News: Atlanta loses Series Finale to Phillies, Robert Suarez Update, More

Braves win big series over Phillies.

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Sep 14 • 8:15 AM EDT • Sports • sports.yahoo.com
Pérez: “Someday Cadillac Will Be the Best Team in F1”

The Mexican driver assures that the American team has the potential to reach the top. He highlights the collective effort in the debut season and the pride of representing the brand.

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Sep 14 • 3:59 AM EDT • Sports • sports.yahoo.com
No-Danger Ranger, Red Sox beat Royals 5-1

Were you worried about Ranger Suárez coming into this afternoon’s game? It’s okay to admit it if you were. Hell, it’s okay to still be worried a tad. The man put up a 5.70 ERA in the month of August, culminating in a no-show performance against the Yankees in what was the biggest series of […]

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Sep 12 • 8:03 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Astros news: Joe Espada provides important Yordan Alvarez injury update

Houston Astros slugger Yordan Alvarez is dealing with an ankle injury concern. Alvarez, a strong American League MVP candidate , is hoping to avoid a lengthy injury absence. While he did not play in Friday night’s 3-1 loss to the Tampa Bay Rays, manager Joe Espada believes Alvarez could return to the lineup on Sunday, via Chandler Rome of The […] The post Astros news: Joe Espada provides important Yordan Alvarez injury update appeared first on ClutchPoints.

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Sep 12 • 6:28 PM EDT • Sports • sports.yahoo.com
Chelsea 2-2 Hull City: What Jakirovic said

Hull City have picked up eight points from their first four Premier League games this season (W2 D2), the only newly promoted sides to gain more points in their first four matches to start a campaign were Nottingham Forest in 1994-95 and Bolton Wanderers in 2001-02 (both 10). Hull City's Mohamed Belloumi became the fifth Algerian to score a double in the Premier League and the first since Riyad Mahrez for Man City against Spurs in January 2023.

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Sep 12 • 12:21 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Álvarez Dispute Puts Barcelona-Atlético Ties Under Strain

Barcelona’s interest in Julián Álvarez has left the club needing to publicly clarify its position, and Barca Universal report that sporting director Deco has now explained why. Atlético Madrid ha...

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Sep 12 • 12:00 PM EDT • Sports • sports.yahoo.com
Dating apps are ditching ‘the swipe’ for meet-ups IRL

Rob Perez only has one dealbreaker when it comes to dating – his partner needs to be a gym rat like him.

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Sep 12 • 5:00 AM EDT • Business • cnn.com
Álvarez Stays Put as FIFA Rethinks Extreme Release Clauses

Atlético Madrid’s refusal to let Julián Álvarez leave for Barcelona has apparently pushed FIFA into rewriting one of its core transfer regulations. MARCA report that FIFA will modify Article 17 o...

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Sep 12 • 5:00 AM EDT • Sports • sports.yahoo.com
The politics and possibilities of ‘AI could kill us all’

I found myself fielding a lot of questions from folks who don’t usually talk much about AI this week. They were mostly along the lines of “do you think AI is going to kill us all?” or “how worried should I be about this human extinction stuff?” Motivating this wave of existential anxiety was the highly dramatic resignation of now-former Anthropic employee Jacob Coxon, who quit his job while publicly sharing his concerns about safety practices at the leading AI companies. More specifically, he declared that almost everyone at OpenAI and Anthropic, the leading AI labs, believes that there’s a decent chance the AI systems they’re producing could “kill us all” by the end of the decade, and the companies aren’t “acting responsibly.” Other AI safety researchers, including those still employed at Anthropic and OpenAI, all confirmed that yes, Coxon is correct, they’re all worried that their company’s products might prove fatal for the entire human race as well. Two more AI employees quit and joined the chorus. Now, the warning shot has been covered everywhere from the Wall Street Journal to Fox News to WIRED to the Guardian. I understand why all this sounds scary, but my response to those who have asked, has generally been: No, you don’t need to worry that AI will kill go rogue and kill us all. But that does not mean we shouldn’t worry, period. Far from it. The companies building AI products are now among the wealthiest and most powerful entities in the world. And they very much are building enormous engines of mass surveillance, extraction, and automation. They can and have allowed their AI systems to carry out felony hacks of other companies, provided the government with autonomously generated kill lists, and sold enterprise technology to firms around the world that is explicitly intended to replace jobs. But “AI” has done these things not because they have all-powerful minds of their own but, ultimately, because people have programmed, calibrated, and directed them to. In other words, it’s not AI we need to worry the most about. It’s the people and corporations working to profit from and gain power by deploying it. The technology is sophisticated, sure, and, especially in cybersecurity contexts, potentially disruptive to plenty of existing systems. But if we want to stop this predatory, profiteering, and extractive form of AI—and it’s worth noting that at this point, most people do—we absolutely can. A quick note/plea: I can only do all of this with the support of readers like you, so if you find value in independent, critical tech journalism and analysis, please consider becoming a paid subscriber. I want to keep as much of this un-paywalled as absolutely possible, and I need your support to do so. Many thanks to all who continue to chip in, it’s very much appreciated. Onward. Subscribe First, some context: AI industry folks like Coxon have been discussing the prospect that AI will destroy humanity for years. Even before the beginning of the AI boom, many working in the industry, from the executive staff to the rank and file researchers, have obsessed over ‘x-risk’, or the possibility that AI will become sentient or semi-sentient and move one way or another to exterminate humanity. This is ostensibly why Elon Musk bankrolled OpenAI in the first place, and is the grounds for his lawsuit alleging OpenAI betrayed its charter by abandoning its nonprofit status to become a commercial enterprise. Many AI engineers and startup founders have calculated their own personal p(doom), or the probability that the tech product they are working on will initiate an actual humanity-extinguishing apocalypse. 10-25% p(doom)s are pretty common. (I wrote about a long weekend I spent among these folks at one of their top conferences here, to give you an idea of their ideas and belief systems.) Sam Altman himself drove the narrative of the imminent rise of a super-powerful AI, or artificial general intelligence, to prominence by declaring that the technology he was building posed an existential risk to humanity. This idea is in other words baked into the DNA of modern AI companies and into the products they engineer. It’s also why the industry is routinely accused, by myself and others, of “doom marketing,” ie, using such proclamations and framings to impart the sheer power of the technology behind your product onto investors, partners, consumers, and the state. Some ambient understanding of this tendency may have helped prevent the press from repeating the claim every time one of the x-risk folks made it over the years, including when they quit their jobs at AI companies while doing so. Yet Coxon’s AI x-risk alarm has broken containment, as they say, and has exposed the idea to the mainstream media once again. This has happened, I think, for a number of reasons. First, when AI CEOs were going around saying AI might kill everyone in 2023, their companies were well-capitalized, but not nearly to the extent they are today. They were more easily dismissed as eccentric geeks of the sort that Silicon Valley is supposed to produce. Now, not only do their products have much greater market saturation, but people are more aware of a) the often unethical ways the executives and companies comport themselves b) the other adverse impacts of AI that have already arrived, and c) the physical cost of building these systems, particularly when it comes to data centers. Finally, toss in the constant stream of headlines in 2026 about AI models going rogue or potentially upending the world’s infrastructure. [ ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) [ With the backlash to data centers, Flock and AI glasses, a mass opposition to big tech is underway. Silicon Valley is in denial. ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) Brian Merchant · Aug 27 [ Read full story ](https://www.bloodinthemachine.com/p/with-the-backlash-to-data-centers) As a result, general sentiment was already overwhelmingly skeptical of AI and its overlords, so the table was pretty well set for someone to come along and say ‘just a reminder, the companies that are building the product that promises to take your job and leave a data center in your neighborhood also think that it might exterminate the human race’ and get a strong reaction from the media and the public. The question is: Should we understand this stuff as hype, strategically fanned to feed already swelling valuations? Is it doom marketing? Genuine cause for alarm that the infrastructure that undergirds modern life is facing a novel threat vector? Or reason to be sincerely worried that AI companies are amassing too much power, and that their products are genuinely dangerous? The answer, I’m afraid, is “yes.” Let me try to untangle all of this a bit, because arguments over how to navigate this moment are extremely heated right now, as they are essentially arguments over how to approach the politics of AI at a moment where there may be a unique opening for action. Those sympathetic to AI alignment concerns and x risk arguments—which increasingly includes a faction on the left who want to shut down AI over safety concerns—argue that people who dismiss AI as all hype have their heads in the sand. Meanwhile, critics of the x-risk narrative—which I might note includes a cadre of investors and tech folks on the right, too—argue that it is hype and can be used to further inflate valuations or for pursuing regulatory capture. The challenge is that many feel that dismissing AI as just hype or purely marketing also diminishes the urgency of taking on the AI industry as the novel and threat to labor, civil society, and the public sphere it is; others that by accepting the industry’s own terms, we imbue it with undue power and enable it. But let’s be clear: Declarations that AI is so powerful it might end the world are a kind of marketing, and anyone who says otherwise is just as off base as those who say that’s all that it is. If you don’t think that these sub-trillion dollar companies have higher-ups who noticed that when their founders talked about super-powerful dangerous AI they got spikes in media interest and phone calls from investors, or that those founders didn’t notice that themselves, and lean into certain narratives to advantage their products, then I don’t know what to tell you. Not all marketing is a Pepsi ad campaign with a celebrity spokesperson. Yet confronting the AI industry should certainly be considered an urgent project. Do I share the x-riskers’ fear that out-of-control, super-intelligent AI agents might end the world? I do not. I’ve read a good deal of AI extinction literature over the last couple of years and I have not come across a credible, step-by-step documentation of how exactly AI might move from self-recursively improving AI to killing every single human on the planet. Most of what I’ve read seems predicated on a sort of reverse Ian Malcolmian logic: Eventually, it becomes smart enough and AI, uh, finds a way (to exterminate humanity). Are the AI companies also overstating and dramatizing what their products can do? Yes, pretty much all the time. They’re in a knife fight for market share and are trying to win customers and government contracts before their investors come knocking. And yet. They have concentrated enormous amounts of compute, have extensive data collection and surveillance capacities, have inserted themselves into the state in numerous capacities, including military kill chains, and they are being run by egomaniacal billionaires who are rushing to monopolize an entire new market. The way I think about their most recent frightening-seeming exploits is not as a “swarm of rogue AI agents building a new civilization” or whatever, but as corporations with a hitherto-unimaginable amount of compute at their disposal recklessly experimenting with automation programs, completely unafraid of any repercussions because we have been unwilling or unable to impose any on them. So I think we should welcome any newfound imperative to hold them accountable. I also think that ultimately, the AI critics, Pause AI folks, leftists, doomers, effective altruists, and, honestly, most of the public, want a lot of the same things: legitimate checks and limits on AI companies’ power, actual transparency into what the companies are doing, and for more of AI to be under public control. (Ultimately, a lot of what animates the x-risk fears are rooted in just that: a fear of losing control.) How we move towards all this, exactly, is the question of the day, and while there’s much to be argued over in terms of building a viable political platform to challenge the AI industry’s power, I do want to cast a vote against one particular approach. Not to pick on Chris here, as there are a lot of folks out there proposing stuff like this, and the policy ideas actually stem from AI safety groups. But not only would this be challenging to land politically (I can already hear the ‘China will beat us to AGI’ calls) and all but unworkable in practice, this approach is a) far too limiting, b) fails to address the current harms caused by AI and c) would likely only wind up serving Anthropic and OpenAI; it’s what regulatory capture looks like in action. Full model transparency is the floor for what should be on offer here. If these companies believe their products will kill us, the very least we deserve is to know how. It’s in the public interest. I would also argue we might get a lot of the way to stopping any currently envisioned robot apocalypse simply by forcing AI companies to assume liability, and to submit to the full brunt of the law. If Sam Altman were liable to be charged with a felony for approving the hack on Hugging Face1, if Google was forced to pay defamation fines each time it published a false and injurious AI Overviews, these companies might suddenly find cause to restrain their models’ output, and we might hear less about rogue AI. We would need to introduce new frameworks and available tools for tracking automated lawbreaking, to be sure, but I’d wager that little would frighten the AI companies more than actually being held accountable for what their products enable. To that end, Illinois has passed an AI liability law, which the industry fought tooth and nail, and Florida is considering one. The next steps would be towards moving AI under public control; again, it’s only reasonable, since everyone, not just AI insiders, should get a say over how a technology whose developers say might kill us is developed and deployed. Dismantling the whole industrial project as currently structured should be on the table, too, pending democratic input. But that’s for another post. For now, suffice to say that while I won’t be losing any sleep about an AI-enabled extinction event, Mr. Coxon and co. have given us an opportunity to underscore the urgency of the clear and present damage AI companies are doing, the extreme power they wield and the extent to which they hold themselves unaccountable, and the abundance of political capital there is out there for taking them on. Subscribe 1 Purely speculative! I do not know if he did or not.

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Sep 12 • 3:59 AM EDT • Politics • bloodinthemachine.com
Barry Alvarez assess impact of Wisconsin's new indoor facility

Former UW athletic director Barry Alvarez shares his thoughts on the Kellner Family Athletic Center during the facilty's ribbon cutting ceremony Sept. 11, 2026.

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Sep 12 • 1:35 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-5%)
wow
75%
love
25%
A.J. Hinch Gives Unfortunate Wenceel Pérez Injury Update

A.J. Hinch says Wenceel Pérez is most likely finished for the 2026 season as lingering vision problems continue following his orbital fracture.

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Sep 11 • 11:10 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-50%)
Salvador Perez Opens Up About His Future With the Royals

The veteran catcher says he wants to play as long as he can, whether that means staying behind the plate or moving to a new position.

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Sep 11 • 4:52 PM EDT • Sports • sports.yahoo.com
USA rink building reuse, golf entertainment complex projects need rezoning in Mishawaka

Developer David Farhan says the former USA Skate Center site's zoning only allows up to two businesses in the 24,000-square-foot building but there isn't demand for such large spaces in that area.

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Sep 11 • 4:02 PM EDT • Entertainment • wvpe.org
Mexico captain denies allegations of involvement in kidnapping plan

Mexico national team captain Edson Alvarez has denied allegations of involvement in a kidnapping after he was accused by filmmaker Juan Jose Lopez Ordonez of participating in a plot to capture him in late 2024. "Over the past several months, my name and image have repeatedly been used to generate greater media attention around a situation that has nothing to do with me.

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Sep 11 • 7:18 AM EDT • Sports • sports.yahoo.com
Iranian VP Invites Regional Authorities to Form Islamic Political Bloc

TEHRAN (Tasnim) – Iran’s First Vice President Mohammad Reza Aref called on regional authorities to embrace rationality, free themselves from dependency and unite under the banner of Islam, proposing the formation of a powerful Islamic economic and political bloc.

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Sep 11 • 7:07 AM EDT • Politics • tasnimnews.ir
NBA’s Dallas Mavericks Seek Zoning for Sports and Entertainment District

The Dallas Mavericks’ chose a likely place to begin the rezoning process for a sports and entertainment district, a onetime thriving mall. The team is looking at 100 acres of land that used to be the Valley View Center. The mall was once home to Bloomingdale’s, Dillard’s and Macy’s in the 1990’s but was shuttered and then ...

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Sep 9 • 1:43 PM EDT • Entertainment • connectcre.com
Birthright launches Global Business Summit, connecting Diaspora donors, Israeli financial figures

Three-day gathering to take place in November, aimed at showing 'a different face of Israel' to group's funders — and maybe attracting new ones

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Sep 9 • 9:03 AM EDT • Business • ejewishphilanthropy.com
Braves News: Bryce Elder sidelined, Robert Suarez update, and more

Atlanta Braves news and notes from Tuesday.

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Sep 9 • 8:20 AM EDT • Sports • sports.yahoo.com
Stacy’s Streamers: Four Players to Start in Week 1

Stacy Perez highlights one player at each position who is worth streaming in Week 1.

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Sep 9 • 2:55 AM EDT • Sports • sports.yahoo.com
D-backs @ Royals discussion

Today’s Lineups DIAMONDBACKS ROYALS Lars Nootbaar – DH Carter Jensen – C Ketel Marte – 2B Bobby Witt – SS Gabriel Moreno – C Vinnie Pasquantino – 1B Geraldo Perdomo – SS Salvador Perez – DH Corbin Carroll – RF Michael Massey – 2B Nolan Arenado – 3B Nick Loftin – 3B Tommy Troy – […]

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Sep 8 • 7:00 PM EDT • Sports • sports.yahoo.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Environmental Health Message from Supervisor Perez

As the Supervisor Fourth District, infrastructure, social services, and Economic Development are critical in building a healthy environment.

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Sep 8 • 8:15 AM EDT • Health • ukenreport.com
$18M Stocking Elementary housing conversion hinges on federal tax credits

Commonwealth Development's plan would preserve Stocking Elementary on Grand Rapids' west side for housing and add two buildings.

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Sep 8 • 5:30 AM EDT • Business • crainsgrandrapids.com
Mets Beat Marlins 9-4 as Eury Pérez Struggles Again

New York’s offense rallies after Miami’s four-run second inning, while Pérez gets roughed up for the third straight start.

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Sep 7 • 4:18 PM EDT • Sports • sports.yahoo.com
Yordan Alvarez's Triple Crown Chase Is Still Very Much Alive

Whether the Astros have been leading the AL West or looking like one of the worst teams in the league, Yordan Alvarez has been solid all season.

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Sep 7 • 4:03 PM EDT • Sports • sports.yahoo.com
Astros' Yordan Alvarez receives brutal Triple Crown prediction from ESPN

This prediction would be heartbreaking for the Astros and Alvarez.

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Sep 7 • 3:43 PM EDT • Sports • sports.yahoo.com
D-backs @ Royals discussion

Today’s Lineups DIAMONDBACKS ROYALS Geraldo Perdomo – SS Carter Jensen – C Ketel Marte – 2B Bobby Witt – SS Gabriel Moreno – C Vinnie Pasquantino – 1B Nolan Arenado – 3B Salvador Perez – DH Lourdes Gurriel – DH Michael Massey – 2B Ildemaro Vargas – 1B Nick Loftin – 3B Tim Tawa – […]

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Sep 7 • 2:00 PM EDT • Sports • sports.yahoo.com
Trump looms over WA’s 3rd District race for U.S. House control

ILWACO, Pacific County — Rep. Marie Gluesenkamp Perez stood inside a brewery in this sleepy town where the Columbia River meets the Pacific Ocean, explaining to a crowd of supporters

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Sep 7 • 4:00 AM EDT • Entertainment • thederrick.com
Girona earns three points at El Molinón

Girona secured three valuable points at El Molinón after defeating Sporting de Gijón 0-2. Quique Álvarez's team delivered a solid and effective performance, especially in defense, against an Asturi...

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Sep 6 • 1:15 PM EDT • Sports • sports.yahoo.com
Away games offer Julian Alvarez a route back at Atletico

Julian Alvarez is going nowhere, at least until January. But the Argentina forward’s public preference for a move to Barcelona over the summer has left Diego Simeone with a delicate problem that no ...

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Sep 6 • 8:30 AM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Alvarez Return Exposes Atletico’s Attacking Problems

Marcos Llorente told ESPN that Atletico Madrid need Julian Alvarez to start scoring, after Los Colchoneros suffered a shock 3-0 defeat at Athletic Club in LaLiga on Saturday. Alvarez came on as a seco...

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Sep 6 • 5:00 AM EDT • Sports • sports.yahoo.com
The Invisible Aftermath: How COVID Changed Young Adult Mental Health and Addiction

Flagstaff Business News The Invisible Aftermath: How COVID Changed Young Adult Mental Health and Addiction

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Sep 6 • 1:14 AM EDT • Health • flagstaffbusinessnews.com
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Braves News: Division standings, Martin Perez blowup, more

Atlanta Braves news and notes from Saturday

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Sep 6 • 12:05 AM EDT • Sports • sports.yahoo.com
Astros Blow Late Lead, Fall to Diamondbacks 4-3/10

Saturday Night Bummer. A rare blown late inning lead by Houston. Diamondbacks 4 Astros 3. The night began with promise, thanks to a forged early lead which has been the formula for success of late. Taylor Trammell began things with a double, advancing to third on Yanier Diaz’s single. Yordan Alvarez […]

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Sep 5 • 10:48 PM EDT • Sports • sports.yahoo.com
D-backs @ Astros Discussion

Today’s Lineups DIAMONDBACKS ASTROS Lars Nootbaar – DH Jeremy Pena – SS Geraldo Perdomo – SS Yordan Alvarez – DH Gabriel Moreno – C Isaac Paredes – 3B Ketel Marte – 2B Jose Altuve – 2B Corbin Carroll – RF Daulton Varsho – CF Nolan Arenado – 3B Christian Walker – 1B Max Kepler – […]

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Sep 5 • 6:30 PM EDT • Sports • sports.yahoo.com
😐 Neutral (16%)
Atlanta Braves Announce Ronald Acuna Jr. Change During Phillies Series

The Atlanta Braves secured a massive 5-2 series-opening victory over the Philadelphia Phillies at Citizens Bank Park on Friday night.Yet, despite the victory, Braves manager Walt Weiss, as he usually does, is once again tweaking his starting lineup for Game 2 of the series Saturday night. The game will feature left-hander Martin Perez on the […] The post Atlanta Braves Announce Ronald Acuna Jr. Change During Phillies Series appeared first on HEAVY.

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Sep 5 • 6:04 PM EDT • Sports • sports.yahoo.com
Braves look to take another in Philly behind Martin Perez

This pitching matchup is scary on paper but is perhaps closer than it looks on the surface

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Sep 5 • 1:00 PM EDT • Sports • sports.yahoo.com
Beyoncé and Selena Quintanilla’s duet: New Spanish-language track blend their voices; Chris Pérez react

Latin music

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Sep 4 • 10:05 AM EDT • Entertainment • hola.com
Pharr EDC wins international award for its Pharr Global Business Hub Partnership Initiative

An interview with Pharr Economic Development Corporation President Victor Perez.

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Sep 4 • 6:04 AM EDT • Business • riograndeguardian.com
Why Julián Álvarez’s Barcelona Dream Still Faces Atlético’s Veto

Julián Álvarez ended the summer window still on Atlético Madrid’s books, but that outcome has settled almost nothing. Barcelona spent the entire market chasing the Argentine, Atlético publicly r...

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Sep 4 • 5:00 AM EDT • Sports • sports.yahoo.com
Thursday Jays Notes

There isn’t much for Jays news this morning. The starters against the Royals: And, our weekly Anthony Santander rumour: Today’s lineups: Today’s Lineups BLUE JAYS GUARDIANS Brett Bateman – CF Steven Kwan – CF Nathan Lukes – RF Chase DeLauter – RF Vladimir Guerrero – 1B Jose Ramirez – DH Jesus Sanchez – LF Jo […]

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Sep 3 • 12:10 PM EDT • Sports • sports.yahoo.com
Athletics' Jose Suarez: Designated for assignment

Athletics' Jose Suarez: Designated for assignment

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Sep 2 • 12:15 PM EDT • Sports • cbssports.com
FDNY Pushing Feds to Add Cardiac, Cognitive Decline to List of 9/11 Illnesses

These diseases have increased over and above what you would expect in aging," said Dr. David Prezant, FDNY WTC Health Program director.

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Sep 1 • 8:00 PM EDT • Health • firehouse.com
Gabriel Jesus: Arsenal forward completes Barcelona transfer in £8.6m deal on Deadline Day

Gabriel Jesus leaves Arsenal having scored 32 goals in 123 appearances for Arsenal since his £45m move from Manchester City in 2022; Jesus move is not expected to impact Barcelonas desire to sign Julian Alvarez

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Sep 1 • 9:45 AM EDT • Sports • skysports.com
Homewood Science Center celebrates new additions

Homewood Science Center Executive Director Edie Dobrez had to speak up to be heard over the sounds of children playing with the center’s educational toys during a celebration Thursday, Aug. 6, of new features. While four youngsters built, traversed and enthusiastically destroyed a modular maze, Dobrez thanked representatives of granting[Read More...]

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Aug 30 • 9:32 PM EDT • Science • hfchronicle.com
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Atletico Stand Firm as Julian Alvarez Exit Push Fuels Rumours

Julian Alvarez missed Atletico Madrid training earlier this week, triggering speculation that the Argentina international had informed the club he was suffering from depression. His agent, Fernando Hi...

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Aug 30 • 12:00 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-20%)
Braves News: Martin Perez, taking care of business, more

Atlanta Braves news and notes from Saturday

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Aug 30 • 12:01 AM EDT • Business • batterypower.com
Braves News: Martin Perez, taking care of business, more

Atlanta Braves news and notes from Saturday

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Aug 30 • 12:01 AM EDT • Business • sports.yahoo.com
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Pharr EDC’s Global Business Hub Positions Region as Binational Trade Powerhouse

An interview with Pharr Economic Development Corporation President Victor Perez.

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Aug 29 • 3:17 PM EDT • Business • riograndeguardian.com
Business U.S. 24 work begins next week

WASHINGTON – The Illinois Department of Transportation announced that pavement patching and resurfacing on Business U.S. 24 (McClugage Road...

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Aug 27 • 4:26 PM EDT • Business • illinois-department-of-transportation.prezly.com
Party politics loom large in non-partisan Tallahassee Commission race

Tallahassee candidates PJ Perez and Tom Derzypolski are clashing over their past party affiliations ahead of the runoff.

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Aug 27 • 6:02 AM EDT • Politics • tallahassee.com
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Minor League Recap: Welbyn Homers, Jake Fox Has Huge Day

Clippers 3, Indians 4 It’s been a tough season for Yorman Gomez, and that continued today. He allowed four earned runs on six hits including three home runs. His ERA on the season is up to 7.19. Steven Perez, Connor Brogdon, and Carlos Hernandez combined for 4.2 scoreless innings of relief. It wasn’t a great […]

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Aug 27 • 12:20 AM EDT • Sports • sports.yahoo.com
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Astros’ Yordan Alvarez nears record held by Yankees’ Aaron Judge

Yordan Alvarez's dominance is making him historically difficult to pitch to.

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Aug 26 • 6:13 PM EDT • Sports • sports.yahoo.com
The key points from Joan Laporta’s crucial meeting with Barcelona’s sports committee

Barcelona are heading into the final week of the transfer window with a clear message emerging from the club’s sporting leadership: Julian Alvarez remains the target, and there is little interest in...

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Aug 26 • 3:40 AM EDT • Sports • sports.yahoo.com
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‘He’s human’: Mason Miller’s rare mistake costs Padres against Pirates

The Sporting Tribune's Fernando Ramirez writes about a rare mistake from closer Mason Miller cost the Padres a much needed victory.

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Aug 26 • 12:53 AM EDT • Sports • sports.yahoo.com
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Perez Hilton 'lucid' after mental health crisis, brother-in-law says

Perez Hilton's brother-in-law shared that the gossip blogger was in a “lucid” state and after receiving treatment for his physical injuries.

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Aug 25 • 9:39 PM EDT • Health • latimes.com
Perez Hilton is 'lucid' after mental health crisis, brother-in-law shares

Perez Hilton's brother-in-law shared that the gossip blogger was in a "lucid" state and after receiving treatment for his physical injuries.

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Aug 25 • 9:39 PM EDT • Health • yahoo.com
VCU’s Daniel Gutierrez receives $3 million grant to train mental healt

The School of Education professor and his team are working on two initiatives that will prepare clinicians globally.

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Aug 25 • 8:00 PM EDT • Health • news.vcu.edu
Julian Alvarez transfer latest: Atletico standing firm on Barcelona as Arsenal become only get out for Argentine striker

Julian Alvarez is holding out for a move to Barcelona, but Atletico Madrid are standing firm on the refusal to sell to their LaLiga rivals; Atletico football expert Ruben Uría believes the only way out for Alvarez is to join Premier League champions Arsenal

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Aug 25 • 3:00 PM EDT • Sports • skysports.com
😐 Neutral (0%)
Alpharetta OKs North Point sports and entertainment district

A plan to transform North Point Mall into a massive sports and entertainment district received city council approval Aug. 24, paving the way for a potential National Hockey League franchise in Alpharetta. In a 4-3 vote, council members approved a master plan amendment, rezoning, a conditional use permit and variances for a mixed-use development anchored by a 20,000-seat hockey arena.

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Aug 25 • 12:00 PM EDT • Entertainment • appenmedia.com
Gardner approves rezoning for proposed $1.5 billion entertainment district

An arts and entertainment district is one step closer to becoming a reality in Gardner, Kansas, after rezoning for the project was approved

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Aug 24 • 11:16 PM EDT • Entertainment • fox4kc.com
Gardner approves rezoning for proposed entertainment district

FOX4KC WDAF-TV

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Aug 24 • 11:14 PM EDT • Entertainment • fox4kc.com
Could politics put your city's funding at risk?

The Trump administration recently admitted to pulling grants over politics. This practice could become more common. How do cities use grant money, and how will they adapt?Fact checking by Sierra Juarez.Your Next Listen — How far can philanthropy go to fill government gaps?Connect with The Indicator — Sign up for The Indicator’s weekly newsletter! — Buy the Planet Money book — Find our socials, YouTube and more! — For sponsor-free episodes, subscribe to NPR+ Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.

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Aug 24 • 3:00 AM EDT • Politics • npr.org
High-Signal Publisher
🥐 An unstoppable Barça, Julián, Vinicius... 5️⃣ stories shaping Monday

Tension at the Metropolitano after the boos aimed at Julián Álvarez headline a matchday in which FC Barcelona showed overwhelming dominance against Elche, Mourinho stepped in amid the 'Vinicius case...

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Aug 24 • 2:50 AM EDT • Sports • sports.yahoo.com
Lou Diamond Phillips reveals he altered his face, lost 25 pounds to play ‘Night Stalker’ role

Lou Diamond Phillips detailed the harrowing lengths he went to convincingly portray notorious serial killer Richard Ramirez in the 2016 Lifetime movie ‘The Night Stalker.’

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Aug 23 • 9:48 PM EDT • Entertainment • ew.com
IndyCar prez: Freedom 250 Grand Prix of Washington D.C. likely to be a one-off

President Trump’s administration and D.C. Mayor Muriel Bowser are interested in turning the Freedom 250 Grand Prix into an annual event, but it’s currently shaping up to be a one-and-done, according to IndyCar President Doug Boles.

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Aug 23 • 12:58 PM EDT • Business • sportsbusinessjournal.com
Deco Travels to Madrid as Barcelona Keep Álvarez Pursuit Alive

Barcelona have not walked away from Julián Álvarez, but Atlético Madrid remain adamant that they will not sell. That impasse was at the centre of Deco’s discreet trip to Madrid, where the Barcelo...

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Aug 23 • 8:35 AM EDT • Sports • sports.yahoo.com
A family business built on faith: How the Ramirezes brought Tequila Mexican Grill & Bar to life

Favorite: Burrito

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Aug 23 • 12:00 AM EDT • Business • lancasteronline.com
D-backs vs Reds Discussion

Today’s Lineups REDS DIAMONDBACKS Elly De La Cruz – SS Lars Nootbaar – LF Sal Stewart – 1B Corbin Carroll – RF JJ Bleday – LF Gabriel Moreno – C Tyler Stephenson – C Geraldo Perdomo – SS Eugenio Suarez – DH Nolan Arenado – DH Matt McLain – 2B Tim Tawa – 1B Dane […]

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Aug 22 • 7:30 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-8%)
Arsenal target one more forward before transfer deadline

The Premier League champions remain open to another attacking signing, with Julian Alvarez admired as Mikel Arteta looks to strengthen an already formidable squad.

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Aug 21 • 6:56 PM EDT • Sports • sports.yahoo.com
🙂 Positive (50%)
UCO FSI Celebrates a Decade of Training Forensic Science Educators Across the Nation

The University of Central Oklahoma’s W. Roger Webb Forensic Science Institute (FSI) recently welcomed 30 middle and high school science teachers from across the country for its 10th annual High School Teachers Forensic Science Curriculum Training.

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Aug 21 • 11:12 AM EDT • Science • news.uco.edu
Business U.S. 20 work in Freeport begins Aug. 24

FREEPORT – The Illinois Department of Transportation announced today that weather permitting, construction Business U.S. 20 (Galena Avenue) will...

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Aug 20 • 1:52 PM EDT • Business • illinois-department-of-transportation.prezly.com
Mother, son accused of embezzling $620,000 from Miami-Dade business to fund lavish lifestyle, police say
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Aug 19 • 7:29 PM EDT • Business • cbsnews.com
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71%
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29%
UCO Recognizes Faculty and Staff at the 2026 Fall Convocation

The University of Central Oklahoma recently recognized faculty and staff for their contributions to the Central community at its annual Faculty and Staff Convocation.

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Aug 19 • 3:32 PM EDT • Science • news.uco.edu
NEWS: Pressley, Ramirez, McGovern Demand Answers of Trump Admin. on Persecution of Political Dissent, Targeting of Left-leaning Political Groups

“Defining political opposition as an existential threat does not make communities safer—it degrades civil liberties, expands state surveillance, enables violence...

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Aug 19 • 3:09 PM EDT • Politics • pressley.house.gov
How One CEO Stepped Up to Save a Family Business

When Nubia Perez stepped into leadership in a time of uncertainty, she brought structure, vision and renewed growth to her family’s manufacturing business.

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Aug 19 • 11:38 AM EDT • Business • chase.com
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Researcher-artist paves the way for science communication

Lulu Perez ‘26 is a behavioral neurosciences alumna. She is a researcher in an FIU lab that investigates how complex sugars can regulate immune and cancer cell function and slow cancer progression. She is also an artist. Perez attended an arts-focused school, where she learned to paint in traditional mediums like acrylic, oil and watercolors,

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Aug 18 • 2:26 PM EDT • Science • communitynewspapers.com
Farmers and ranchers win on NIETC cancellation

The Department of Energy rolled into Lamar last week and Office of Electricity Assistant Secretary Katie Jereza stood in her neat, green suit in front of a room filled with farmers, ranchers and landowners. The crowd was filled with straw cowboy hats, sweat-stained ball caps, tee shirts and button-down chambray shirts that had seen more […]

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Aug 17 • 2:45 AM EDT • Politics • coloradopolitics.com
Barcelona want Julián Álvarez to make his Atlético stance public

Barcelona are expecting Julián Álvarez to publicly declare his desire to leave Atlético Madrid now that the World Cup has concluded, according to SPORT. The report claims the Blaugrana have set Jul...

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Aug 16 • 12:00 PM EDT • Sports • sports.yahoo.com
MLB Player Props & Best Bets for Today, August 16

Colby Marchio is handing out his favorite MLB player props for Sunday, Aug. 16, featuring Sean Burke, Eury Perez, and Dean Kremer.

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Aug 16 • 10:51 AM EDT • Sports • sports.yahoo.com
Perez Hilton created the internet culture that watched his mental health crisis unfold

The celebrity gossip blogger became as famous as the stars he covered before social media upended his business model.

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Aug 16 • 6:00 AM EDT • Health • latimes.com
Barcelona Add Sporting CP Striker to Álvarez Shortlist

Barcelona are exploring Sporting CP forward Luis Suárez as a potential alternative to Julián Álvarez, with Atlético Madrid continuing to resist a move for the Argentine international. Fabrizio Rom...

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Aug 15 • 12:05 PM EDT • Sports • sports.yahoo.com