SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " removal " 231 found 🔀 AI-powered Shuffle
EU Drops Battery Removal Requirement for Apple Watch and AirPods
The European Commission yesterday adopted new exemptions to its Batteries Regulation that free the Apple Watch and AirPods from having to offer user-removable and replaceable batteries. The EU's Batteries Regulation generally requires consumer products sold in the region to let users swap out their own batteries, a push meant to keep devices in use longer and make it easier to recover materials for recycling.
How two brothers built a 7-figure junk removal business
In 2021, the McKinney brothers pooled their savings to buy a $4,000 Ford F-150. It became the start of their junk-removal business, Junk Teens.
Danville Field Notes: BWXT employees earn data science certifications through Danville workforce development program
Plus: A local relief center plans for capital improvements, Pittsylvania pushes against an effort to minimize tree removal at anticipated micro-resort, and a music series begins in Danville’s River…
Accel Entertainment (ACEL) Leaves An Index, Is The Stock Still Undervalued?
Accel Entertainment (ACEL) was recently removed from the Russell 2000 Dynamic Index, a change that can affect how some index-linked funds treat the stock, as well as how investors think about liquidity and visibility. See our latest analysis for Accel Entertainment. The recent index removal comes as Accel Entertainment’s share price sits at $12.42, with a 90-day share price return of 6.61% and a 3-year total shareholder return of 16.07%. This suggests momentum has been building over the...
How Flutter’s Removal from Key Russell Growth Indices Will Impact Flutter Entertainment (FLUT) Investors
In late June 2026, Flutter Entertainment plc (NYSE: FLUT) was removed from multiple Russell growth benchmarks, including the Russell 1000 Growth, Russell 3000 Growth, Russell Midcap Growth, Russell 3000E Growth, and Russell Small Cap Comp Growth indices. This broad index exclusion matters because it can prompt passive and index-tracking investors to sell shares, potentially amplifying trading volumes and sentiment shifts around Flutter’s stock. Next, we’ll examine how Flutter’s removal from...
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
US service member arrested at Capitol after calling for Trump’s impeachment
A US Air Force major was arrested on the steps of the US Capitol on Wednesday after delivering a speech calling for the impeachment and removal of President Donald Trump and Vice President JD Vance.
Portland to consider removing zoning rule that limits entertainment licenses
Could the removal of a 30-year-old zoning rule lead to more activity in downtown Portland? Some business owners hope so.
Accel Entertainment (ACEL) After Russell 2000 Exit Has Undervaluation Back In Focus
Index removal puts Accel Entertainment back in focus Accel Entertainment (ACEL) was recently removed from the Russell 2000 Dynamic Index, an event that can influence institutional ownership patterns, index tracking fund flows, and short term trading activity around the stock. See our latest analysis for Accel Entertainment. Against that backdrop, Accel Entertainment’s recent share price moves have been mixed, with a 1-day share price return of 1.27% but a 7-day share price return that...
Alleged Cuban influence operative, family in federal custody after Rubio revokes legal status
A Cuban national who authorities say worked for regime-linked influence organization ICAP has been taken into federal custody pending removal from the U.S.
NHS to take over troubled Northampton mental health hospital
The removal of almost 300 patients from the Northampton site was ordered by NHS England in March.
PlayStation Removing Purchased Content From Your Library Again
Sony Interactive Entertainment is conducting another round of purchased content removal from the PlayStation library.
Trump's DOT clears a pedal-free path for Tesla and Zoox
The NHTSA is proposing allowing the removal of pedals and steering wheels for AVs, making it easier for Tesla and Zoox to pursue alternative designs.
Trump administration identifies more than 500 migrant children for removal from the US, senator says
The Trump administration has identified more than 500 unaccompanied migrant children in US government custody to be potentially removed from the country, according to Democratic Sen. Ron Wyden.
Joe Manganiello reveals secret health battle, 'live-saving' organ removal
Joe Manganiello details a previously unknown health ordeal that required a "life-saving" organ amputation in his upcoming memoir "Bloodlines."
Biden judge overruled on key Trump immigration policy
Federal appeals court revives Trump administration's nationwide expedited removal policy, allowing fast-track deportations of eligible illegal immigrants.
'True Blood' star Joe Manganiello shares secret multi-year health battle, organ removal
Manganiello is detailing his journey in his memoir, "Bloodlines," out October 13.
Political watchdog fines Newsom for failing to report $5.5M in solicited donations on time
The California Fair Political Practices Commission said most of the violations were for failing to report that Gov. Gavin Newsom and his his staff directed inquiries from companies and foundations to offer help after the Los Angeles wildfires to the California Fire Foundation.
Julio Rodriguez News Emerges After Removal From Mariners Lineup
The Seattle Mariners revealed an update on center fielder Julio Rodriguez.
MU Health care lays off 74 employees, closing Hy-Vee Quick Care locations
MU Health Care said an "organizational redesign" includes the removal of 74 employee positions and the closure of Hy-Vee Quick Care clinics.
RFK Jr. demands journal explain removal of vaccine study used to support his childhood immunization changes
Health and Human Services Secretary Robert F. Kennedy Jr. is demanding answers from a science journal on why a study regarding vaccination and sudden infant death was removed from the publication. …
Jim Acosta ruthlessly mocked for comparing removal of Trump’s name from Kennedy Center to fall of Berlin Wall
Jim Acosta live-streamed for nearly 11 hours awaiting the removal of Trump's name from the Kennedy Center, then compared it to the Berlin Wall falling.
Trump's Name Removed From Kennedy Center Building
The removal of Trump’s name came after a federal judge ordered the Kennedy Center to restore its original name by Friday, June 12.
Trump's name removed from Kennedy Center in predawn operation
President Trump's name was taken off the Kennedy Center after a federal judge denied the administration's request that his order be put on hold.
Judge denies DOJ request to pause removal of Trump's name from Kennedy Center
A federal judge had ruled May 29 that physical and digital signage with President Donald Trump’s name must be taken down within 14 days
Kennedy Center board plans to appeal judge’s ruling over removing Trump’s name
President Donald Trump’s handpicked Kennedy Center board of trustees discussed plans to appeal a judge’s ruling — hoping to halt the ordered removal of Trump’s name from the building.
Lawmakers continue to discuss potential Wyoming Business Council reforms
During the second meeting, the committee moved to revive the consensus block grant funding program. Plus, the Legislative Service Office (LSO) was directed to draft a bill based on agency recommendations for reforms and removal of underutilized WBC programs.
77 headless skeletons found in a field date back 7,000 years
The carefully arranged Neolithic remains show signs of skillful skull removal.
Two men, business indicted for illegal dumping in Summit County
Yost named DeShawn Dixon, 47, of Akron; Zachary Dupert 34, of Akron; and his business, SOS Junk Removal.
Two men, business indicted for illegal dumping in Summit County
Yost named DeShawn Dixon, 47, of Akron; Zachary Dupert 34, of Akron; and his business, SOS Junk Removal.
2 Ohio men, business charged in illegal dumping investigation
Akron residents DeShawn Dixon and Zachary Dupert, along with the business SOS Junk Removal, were indicted on illegal dumping and open burning charges.
Weed removal business helps local find the right path
FAIRMONT – While the Curly Leaf Pondweed issue in Fairmont has affected many, removing it has helped one resident stay clean and keep the lakes clean. Dominic Hill of ClearShore Solutions said he was a troublemaker in his younger years and struggled with drug and alcohol addiction. That all changed four years ago when he […]
2 men, business charged, accused of illegal dumping in Copley
A Summit County grand jury has indicted two men and a junk-removal business accused of illegal dumping in Copley Township, a state official says.
Alsobrooks, public health advocates warn of a 'leadership vacuum' at HHS under RFK Jr.
US Sen. Angela Alsobrooks calls again for removal of US Health and Human Services Secretary Robert F. Kennedy Jr. as deadly outbreaks of hantavirus and Ebola pose international public health threats
Questions about President Trump’s health swirl after delayed release of yearly health report
Biodegradable brain probes eliminate the need for risky surgical removal
Soft and flexible brain sensors that naturally dissolve away after a few weeks could make surgical removal obsolete.
Colorectal cancer risk linked to gut microbiome alterations | Harvard T.H. Chan School of Public Health
More than a decade after removal of an adenoma—a precancerous mass—from the colon, alterations to the gut microbiome and metabolites remain and may drive heightened risk of colorectal cancer, according to a new Harvard Chan School study.
Platner stands by ad slamming Red Sox over private equity
Platner has since been all too eager to capitalize on the ad's removal, using it to push his populist message as he campaigns to unseat longtime Republican Sen. Susan Collins in Maine.
New documentary takes closer look at post-removal education
A new documentary from the Cherokee Nation explores the legacy and generational impact of post-removal seminaries established for young Cherokees in the mid-1800s.
Texas high court rejects removal of Democratic lawmakers who led quorum break
The all-Republican court dealt a blow to Gov. Greg Abbott and state Republicans in their efforts to severely punish the more than 50 Democrats.
Texas high court rejects removal of Democratic lawmakers who led quorum break over redistricting
The Texas Supreme Court has refused to declare that Democratic state lawmakers who briefly left the state last year in a quorum break to stop a vote on new congressional voting maps pushed by President Donald Trump vacated their offices.
Attorney General threatens 8 New Orleans leaders with removal from office in court clerk battle
The AG warned Mayor Helena Moreno, District Attorney Jason Williams and five City Council members they were at risk of violating state "usurper" statutes.
First-of-its-kind drainage device helps limit heart failure rehospitalizations
This new catheter-based device for lymphatic drainage showed early potential to be a new treatment option for acute decompensated heart failure.
Philippine Congress poised to impeach Vice President Sara Duterte
Impeachment complaint seeks Duterte's removal from office and perpetual disqualification from any government post.
Official-looking Xperia 1 VIII images show new design, colors; launch date, price increase tipped
After leaked Amazon listing, fresh marketing images have revealed the redesigned Sony Xperia 1 VIII in all colors. Set for a potential May 20th launch, the 2026 model faces controversy over a rumored price hike and the removal of the continuous optical zoom.
Military spouses head to the Hill, push for removal of barriers to small businesses to boost retention
Advocates aim to introduce the Military Spouse Small Business Recognition Act, arguing it could improve access to capital, national security and retention.
State, federal lawmakers call for ban on endangered marine species capture after 2025 manta ray controversy
'The removal of even one individual — especially a reproductive-age female — can have significant and lasting consequences for population stability and recovery.'
‘The Seminarians: Sovereignty Through Education’ premieres May 7 in Tahlequah
Just 12 years after forced removal, Principal Chief John Ross and the Cherokee National Council made a powerful declaration about the Nation’s future with the opening of the Cherokee Male
Brewers Make Brice Turang Announcement After Removal From Lineup
The Milwaukee Brewers removed Brice Turang from the lineup.
Cesar Chavez Boulevard signs removed impacting local businesses a second time
A corridor in southeast Fresno is undergoing another name change, impacting local businesses as the city removes and replaces hundreds of Cesar Chavez street signs.
Krafton's removal from Subnautica 2 Steam page "blown up a little bigger than it was meant to", as developers emphasise continued co-publishing support
Krafton has confirmed to Eurogamer that it will continue its collaboration with Unknown Worlds on Subnautica 2 following Steam page debacle.
Why The Narrative Around Madison Square Garden Entertainment (MSGE) Is Shifting With New Street Signals
Recent Street research around Madison Square Garden Entertainment has produced several price target moves, including individual increases of between US$2 and US$6, while the consolidated target shift sits at about US$2. Bullish initiations and fresh coverage from major firms such as JPMorgan highlight growing attention, even as the removal from Goldman Sachs' US Conviction List and more cautious targets show that opinions are still split. In the sections ahead, you will see how these...
Phillies ace Zack Wheeler set for Saturday debut in return from rib removal, thoracic outlet surgery
Supreme Court’s high-stakes term could reshape presidential power, immigration, voting rights
The Supreme Court’s term is packed — birthright citizenship, presidential removals, voting rules, transgender sports and more. Constitutional law expert Rod Sullivan joins News4JAX anchor Bruce Hamilton on this week’s episode of Politics & Power to discuss what’s at stake and why it matters to you.
New Chair of Quietly Powerful Multnomah County Health Board Ousted
Chambers said she did not think her removal was reasonable, though she acknowledged that the matter was still raw. She also acknowledged there is a bigger story here.
Dallas County GOP Chair Allen West resigns amid push for his removal
His resignation comes after he made a controversial decision among his party to return to countywide voting for the May 26 runoff.
Midtown Sacramento businesses react to sudden parking removal for construction
Businesses in midtown Sacramento say they were given little warning that street parking on part of J Street would be removed because of construction on a new apartment project, raising concerns about the impact on customers and daily operations.
Swalwell and Gonzales resign from Congress under threat of expulsion
Reps. Eric Swalwell and Tony Gonzales resigned from Congress Tuesday, moments before their House colleagues were prepared to set in motion their swift removal.
Disney quietly delists 15 more games on Steam, including a couple of classic Star Wars titles
After 14 removals earlier this year, another 15 Disney-owned games have suddenly disappeared from the Steam store.
How vibe coding app Anything is rebuilding after getting booted from the App Store twice
Anything is planning to launch a desktop companion app to aid mobile app development after its App Store removal.
Microsoft Rejects Speculation It’s Axing Carbon Removal Business
Microsoft Corp., the world’s biggest investor in carbon removal projects, rejected speculation that it is abandoning its efforts to build out the technology.
Carbon removal project supports Maine’s blue economy, broader marine health
MIT researchers introduce a chemical-free approach to balancing ocean acidity that protects marine life and could have huge impact on the global aquaculture market.
Trump post appearing to depict himself as Jesus sparks backlash from religious right
Evangelical and Catholic allies call the post “blasphemous” and urge its removal in a rare public break from a base that has largely stood by Trump.
Cult-Hit Doki Doki Literature Club Fights Sudden Android Removal
The acclaimed visual novel had amassed thousands of positive user reviews
House Dem leaders open door to 25th Amendment after rank-and-file push for Trump's removal
House Democrats reignited 25th Amendment discussion as leadership scheduled a briefing amid calls from members to remove President Trump from office.
Scientists just found a hidden “drain” inside the human brain
A hidden waste-removal pathway in the brain has finally been caught in action. Using cutting-edge MRI scans, researchers discovered that fluid flows along the middle meningeal artery in a slow, lymphatic-like pattern—very different from blood. This confirms the presence of a previously unknown drainage hub in humans. The finding could transform how scientists approach brain aging, injury, and diseases like Alzheimer’s.
Wausau Mayor Doug Diny won’t face charges over ballot drop box removal case
The review determined that the box didn’t meet the state’s definition of “ballot box” in part because it was sealed and didn’t have any ballots in it.
Live updates: Democrats demand Trump's ouster; Republicans win Georgia special election
Get live updates and the latest news as Democrats demand Trump's removal, Republicans win Georgia's special election, and Wisconsin Democrats expand their majority on the state Supreme Court
Alex Jones Calls for Trump’s Removal After Panicking About Failing Health
The former stooge has reached the end with Donald Trump.
Could the 25th Amendment be invoked against Trump? Here's how it works
President Donald Trump’s profanity-laced Easter Sunday social media post threatening to bomb civilian infrastructure in Iran led some Democratic lawmakers to call for his removal via the 25th Amendment.
How to ‘detox’ your body for free without juice, teas or flushes
Feel like your body needs a reset? What if we told you that you can ‘detox’ for free by leveraging your body’s natural waste removal systems. PolitiFact shares how to do some spring cleaning without paying for a “juice cleanse” or “detox diet.”
FY2027 Budget Request Slashes Billions in Science Funding
The Trump administration is requesting the cancellation of billions of dollars in funds for space science, renewable energy, carbon removal, and climate change education in its FY 2027 budget.
Slay the Spire 2 nerfs card removal, buffs shivs, and adds a new reward system
New Slay the Spire 2 patch notes include a rework for Borrowed Time, a replacement for the Gloom Ascension, and a system called Badges.
‘Good riddance’: Mass. politicians react to Pam Bondi’s removal as attorney general
The move ends the contentious tenure of a loyalist who upended the Justice Department’s culture of independence from the White House.
It's Your Business | Taking care of business
In addition to dog waste removal at residential and commercial properties, Poo Squad Champaign also offers a sanitation treatment that deodorizes the yard and kills bacteria, said owner Avian Gerdes.
Pokémon Champions' removal of IVs led to a "heated discussion" with one of the franchise's original devs
Settle it...with a Pokémon battle!
Photos: Pro Football Cares Sports Emergency Response Training at Raiders HQ
A Pro Football Cares Sports Emergency Response Training was held at Raiders HQ where athletic trainers and coaches were able to participate in a series of simulations on football equipment removal, cardiac arrest and exertional heat stroke.
Startups juice carbon removal with power generation
The era of relying on carbon removal revenue alone is over.
The brain's cleaning system can be boosted to rid Alzheimer's proteins
A duo of drugs that boosts our glympathic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease
Gen Z brothers bought a $4,000 pickup truck to start their business—now it brings in $3 million a year
Kirk and Jacob McKinney found entrepreneurial inspiration at a local dump, launching junk removal and reselling business Junk Teens while still in high school.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The US in Brief: A forced removal
The latest news in US politics, with coverage of Donald Trump’s second term.
Leavittsburg Dam removal causing struggles for area business owner
Youngstown, Ohio's #1 Locally owned, locally connected television news station.
Business owners sue comptroller after their removal from state minority business program
Women- and minority-owned businesses were removed from the Historically Underutilized Business Program in December by acting Comptroller Kelly Hancock, who argued he was ending a DEI program.
Business owners sue comptroller after their removal from state minority business program
Women- and minority-owned businesses were removed from the Historically Underutilized Business Program in December by acting Comptroller Kelly Hancock, who argued he was ending a DEI program.
Wenatchee entrepreneur turns junk removal into growing NCW business
Springtime often inspires people to clean out garages and sheds and restore their homes’ environments. Hauling unwanted items, or “junk,” is one way to achieve that.
China removes nine military officials ahead of key political meeting
No official reason for the removal was given, but it comes ahead of the country's key Two Sessions meeting.
Ohio State students, health care workers demand removal of Les Wexner's name from campus
There are calls to remove Les Wexner's name from Ohio State University campus facilities, including the medical center.
Coalition Files Lawsuit to Challenge Censorship, Erasure of American History and Science at National Parks
Groups Unite to Protect “America’s Largest Classroom” From Unlawful Removal of History and Science from Park Displays BOSTON – A coalition of organizations committed to protecting America’s national parks, preserving and sharing history, promoting scientific literacy and access, and providing high-quality interpretive materials united today to challenge a new U.S. Department of the Interior policy that continue reading
Coalition sues to block removal of history, science displays from US national parks
A coalition of six conservation and education organizations sued the US Department of the Interior on Tuesday, challenging a policy that has led to the removal of exhibits about slavery, climate chang...
JMU business student owns and operates junk removal service
Colin Wright, a northern Virginia native, spends his free time away from school helping people get rid of their unwanted junk through his business, Colin’s Haul’n.
Curling drama grows as Britain hit with violation
The curling controversy at the Winter Olympics has widened as increased surveillance of matches resulted in the removal of a stone thrown by the British men's team for the same alleged violation that burned the Canadians two days in a row.
Inside Trump’s removal of DOJ antitrust chief Gail Slater
Gail Slater was ousted for failing to zealously pursue Trump's affordability agenda, sources told Fox News Digital.
Google expands tools to let users remove sensitive data about themselves from Search
Users will be able to more easily request the removal of results that include private information or non-consensual explicit imagery.
Indie dev claims the sudden takedown of its game was due to Warhammer creator Games Workshop, and a set of familiar-looking shoulder pads
Tundra Interactive has spoken about Void War's temporary removal from Steam, claiming it was due to a DMCA from Games Workshop.
DC starts issuing fines for businesses, residents who haven’t cleared sidewalks
Nearly two weeks after a snowstorm, D.C. has resumed issuing fines to residents and businesses that fail to clear sidewalks as inspectors enforce snow removal rules to keep pedestrians safe.
Asbestos removal stalls cleanup at burned Nederland shopping center, businesses moving elsewhere
UVA student business-owners take on icy parking lots
Seeing the need for snow and ice removal services, UVA student business-owners took up the task.