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ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots
The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.
Syria’s Democratic Transition: Building Institutions Alongside Political Competition
Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit
As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...
Stateliner Pride on Display: Phillipsburg Band and Alumni Unite at Halftime
Phillipsburg’s Stateliner band and alumni joined for a halftime performance celebrating school tradition, pride and community at Friday’s football game.
Rep. Haley Stevens sidesteps whether she still supports El-Sayed, criticizes outreach to Black voters
AI-generated video heats up suburban Texas political clash
Fort Bend County has seen plenty of controversy at its highest levels.
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
GeForce Unlocked: Modders Boost RTX 20, RTX 30, and RTX 40 Compute Performance by Up to 2x
NVIDIA's GeForce RTX 30-series and RTX 40-series graphics cards are based on the same dies as their professional-grade GPUs. This means the compute potential of consumer-oriented RTX GPUs is restricted by NVIDIA's firmware stack, but modders have managed to unlock the instruction issuing rate...
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign
Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say
A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…
Instacart Stock What Health Benefits Deal And $5 Million Settlement Mean
Instacart parent Maplebear has agreed to a US$5,000,000 settlement with U.S. authorities over past PERM hiring practices and has been selected by True Rx Health Strategists to power an employer funded healthy food benefit through Instacart Health Fresh Funds starting in 2027. The True Rx program positions Instacart within pharmacy benefit design and ties employer spend directly to clinically supervised food choices. The settlement adds compliance obligations, policy changes and monitoring...
Inside California Politics: State Senate candidate John Erickson
(Inside California Politics) — California’s top-two primary system often leads to same-party general election races, often between two Democrats, and this year is no exception. Two weeks ago on Inside...
Culture House Wants to Turn Creator Connections Into Lasting Businesses
Culture House connects creators directly with investors and operators, helping turn cultural influence into sustainable businesses.
Investment driving growth at NWS Crane
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Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
Physician Mental Health and Health System Privacy: Why Doctors Avoid Their Own EHR
In most organizations the default access model was built for patient care, not for protecting colleagues. A nurse on another unit, a resident who rotated with them, a department administrator: any of them may technically be able to open the record, even when policy says they should not.
Business co-owner kills man ‘acting irrationally’ outside Zumba class, NC police say
The business co-owner was carrying a firearm, Spindale police say.
One Underrated Timberwolves Wing Gets High Praise From Chris Finch
Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.
‘Dream big’: The Seattle-area kids and teens launching businesses
Some among the Seattle area's Generation Z and Alpha age groups are diving headfirst into entrepreneurship.
Trump campaigns in Michigan one day after Obama rallied against him
President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.
Can GE Vernova's Gas Turbines Make Up for a Collapsing Wind Business?
It's a red flag investors would rather not see waving, but most of them may not have put this shift in its proper perspective.
Sources: Leeds hit by new hurdle in Nicolo Tresoldi race
Daniel Farke in a press conference with Leeds, with Paraag Marathe at Elland Road
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Politics chat: The polls show a Democratic sweep in the midterms. Can you trust them?
If you look at the few truly competitive seats, polls show a more complicated picture of momentum toward the Democratic Party in midterm House races. For the Senate, Republicans are on defense.
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
Jodi's Journal: The end of an on-air era
Congratulations to a local broadcasting legend as Bill Zortman logs off the air later this week after a 60-year career.
Scientists overcome a hidden obstacle to more powerful quantum computers
Scientists have discovered a way to operate multiple silicon qubits simultaneously with remarkable accuracy, overcoming a major challenge in scaling up quantum computers. Their new technique maintained accuracy of approximately 99.9% even when all five qubits were running at once, opening the door to larger and more powerful quantum processors.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
Just two drinks a day may be far riskier than you think
A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.
How whimsical Hands Gallery became a fixture in downtown SLO for 35 years
The popular shop offers a curated mix of local art, crafts, gifts and more on Higuera Street.
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
Sarkozy's son warns violent protests in France could worsen amid political unrest
Louis Sarkozy, son of former French President Nicolas Sarkozy, discusses violent unrest in France, the influence of far-left groups and the country’s immigration and economic challenges.
Former Minecraft lead, Xbox veteran and COO Helen Chiang "fired" for "policy violations"
A new report suggests that Helen Chiang, recently appointed as Xbox Chief Operations Officer, was terminated for "policy violations," although there's no word on exactly what.
Review: 'Whalefall' a big fish tale thriller within a fraught father/son relationship
Movie reviewer Joshua Hill says 'Whalefall' combines a fraught father/son relationship with a suspenseful narrative featuring excellent sound design and imagery.
Franciscan Health, Tonn and Blank Plan Michigan City Medical Office Building at Former Marquette Mall
Franciscan Health, in partnership with Tonn and Blank Construction, is planning a medical office building on a portion of the former Marquette Mall property. Franciscan Health plans to operate a …
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
Polish team unearths ancient human remains and mystery giraffe skull in Tanzania
The discoveries could shed new light on how prehistoric communities lived, migrated and treated their dead.
AV2 Video Codec Adoption Talked Up, SVT-AV2 Being Developed
Back in May the AV2 v1.0 specification was released for this next-generaton, royalty-free video codec
Antarctica’s “Doomsday Glacier” Could Raise Sea Levels Twice As Much as Scientists Feared
Even without further warming, Thwaites Glacier could contribute twice as much to sea level rise by 2100 as previously estimated, according to a revised ice sheet model. Thwaites Glacier in West Antarctica has been retreating and thinning rapidly, while satellites show substantial acceleration in its ice flow. Traditional ice sheet models have depicted slower movement,
18 Once-Common Things That Quietly Vanished From Our Lives
"I texted one of those numbers on the TV to buy a ringtone back then. Good times. Then smartphones came around, and I've kept my phone on vibrate for over 13 years now."
This fifth-generation family business in rural Pa. is making 4,500 brooms for Salem
On Etsy, the Meckleys have made close to 20,000 sales.
The educational divide could spell trouble for Republicans
Republicans tend to run better among voters without a college degree than those with one, which has battered Democrats in recent presidential elections. But that same pattern could give Democrats a potentially decisive boost in next month’s midterms.
Latino businesses still fearful amid ICE sightings 8 months after Operation Metro Surge
A handful of new Latino eateries have opened on Payne Avenue, as others have slashed hours or remain closed certain weekdays.
‘Talking to every single person matters’: ‘prairie populists’ canvass the rural US heartland to win in midterms
Democratic and independent candidates stump the US midwest and prairie states, hoping to win over Republican strongholds
That Ramaswamy ad is repugnant. And it will eventually be seen as a gift to Trump
If Ramaswamy goes down, Trump will spin it that Democrats and the corrupt media misrepresented the ad and lied about Ramaswamy.
Nevada's Republican governor fights to survive Trump undertow
Joe Lombardo is no MAGA warrior, but his Democratic opponent ties him to the president at every opportunity. Lombardo hopes Nevada voters judge him on his performance, not Trump's.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Reliably Democratic Colorado and Washington have ballot measures that would bar transgender girls from some sports competitions
KIII 3 News
KIII 3NEWS is the ABC affiliate in Corpus Christi, Texas, operating to serve, inform and improve communities in the Coastal Bend. The station began broadcasting in South Texas on May 4, 1964. Today, KIII 3NEWS dominates one of the fastest-growing markets in Texas. The station’s service to the community and commitment to local news and weather coverage has consistently made it the Coastal Bend's news leader for decades.
Gov. Meyer announces the inclusion of the Verizon BEAD Project
Governor Matt Meyer announced the addition of the Verizon Broadband Equity, Access, and Deployment (BEAD) project to the JobsFirst Accelerator program.
Democrats Have Edge Across Four Key House Races in Pennsylvania, Polls Find
Democratic candidates are ahead in two, hold a narrow edge in a third and are tied in a fourth, new polling shows. The seats embody the fights playing out nationwide in the midterms.
Incarcerated entrepreneurs pitch a second chance
Incarcerated men in Ohio are learning entrepreneurship skills to help them succeed after their release from prison.
Democrats Bob Brooks, Paige Cognetti lead GOP incumbents in pair of key Pa. swing seats
Republicans are on pace to lose the two U.S. House seats they flipped just two years ago, according to a new Inquirer/New York Times/Siena University poll.
Bust companies revived in ‘phoenix’ deals more likely to fail again, study finds
Exclusive: Research for the Guardian says ‘pre-pack’ administration deals pay far less to creditors
Independent candidates sense a moment in the West. Democrats are hoping they're right
As they look to win the Senate, Democrats are hoping that independent candidates in Nebraska and Montana can help them topple Republicans in a part of the country where their own brand is hurting.
In Arkansas, Democrats see an opening at the edge of the competitive midterms map
In a sign of the potentially dire midterm political environment, Republicans have spent millions of dollars playing defense in Arkansas, one of the most conservative states in the country.
Liverpool committing to Barcelona model, massive change for club
Liverpool are committing to the Barcelona model. It's a massive change for the club - but will it pay off?Liverpool have a transfer strategy under Jurgen Klopp and it was a wildly successful one. They...
Opinion | East Asia’s cultural economies are bridging politics-driven divides
The cross-border penetration and appeal of cultural products throughout and beyond East Asia is making openings beyond traditional diplomacy.
Bayern bosses offer differing assessments of Lennart Karl’s development
Bayern Munich honorary president and supervisory board member Uli Hoeneß has spoken strongly about Lennart Karl, insisting that the highly rated youngster is still far from being a superstar. In an i...
Guest opinion: Partisan politics don’t belong in Montana’s courtrooms
As retired district court judges who worked in courtrooms across Montana, we know there is no Democratic or Republican way to handle the everyday court cases Montanans face. That’s why we support Constitutional Initiative 132 to keep our judicial elections nonpartisan.
What business thinks of the politicians and parties
Business leaders are hard to impress this election. In the Herald's annual “Mood of the Boardroom” survey, they give poor or middling marks to almost the whole political class, including the two former business executives running the Government's economic policy, and several ratings are among the wo
Union to Dedicate Historic Marker Commemorating Battle of Connecticut Farms as Part of America's 250th Celebrations
Union – The Township of Union Planning Committee for the 250th Anniversary of the United States, in partnership with the Union Township Historical Society, invites residents and history enthusiasts...
Events for November: Marathons, Movies, Music, Thanksgiving Magic and the Holidays Arrive
November is when New York changes costumes. The pumpkins disappear, the holiday lights begin to sparkle, and the city trades Halloween mischief for marathon madness, documentary premieres, world-class comedy, spectacular performances and one of the most beloved parades on the planet. It is a month when Fifth Avenue belongs to runners, veterans and giant balloons, […]
Economic woes transform the Midwest into a massive midterms battleground
Democrats could be poised for a revival in the heartland, as furor over high costs and doubt about President Donald Trump’s willingness to change the nation’s trajectory threaten to loosen the GOP’s grip on working-class voters.
READERS' CHOICE | Impact Realty Group makes its mark with Best Small Business win
A locally owned and operated real estate brokerage has been named Best Small Business in the 2026 Texarkana Gazette Readers' Choice Awards.
Singapore Airlines to Introduce Next-Generation KrisWorld In-Flight Entertainment from 2027
Singapore Airlines will introduce its next-generation in-flight entertainment system, KrisWorld, from 2027 onward. The system will be installed on a total of 41 refurbished Airbus A350-900 and A350-900ULR aircraft, as well as on Boeing 777-9 aircraft scheduled for future delivery. It will feature 4K high-resolution touchscreens, spatial audio, noise-canceling headphones, and Bluetooth connectivity for passengers’ personal headphones. More than 2,500 items of content, including movies, television programs, music, and podcasts, will be updated monthly. The system will also include a “Wellness Planner” featuring sleep and meditation tracks, breathing exercises, and stretches that can be done at passengers’ seats. In addition, Starlink high-speed in-flight Wi-Fi service will be progressively introduced from […]
Obama seeks to shore up Abdul El-Sayed with Black voters at Michigan rally
The former president spoke alongside the Democratic Senate nominee in Detroit as the Senate contest could come down to the city’s large Black electorate
NA boys sweep Erie Challenge
North Allegheny traveled to Erie, PA to take part in the Erie Challenge over the weekend. The NA boys swept their schedule going 2-0 on the weekend while the girls went 0-3. Girls The NA girls dropped a 15-5 match against Germantown to get the tournament going. Margarita Tokareva had three goals while Sania Bedi and Vania Rathee each scored. Rathee… More »
Alabama Renaissance Faire celebrates its 40th year
FLORENCE — Alabama’s Renaissance Faire is celebrating its 40th year this weekend at “The Fountain on the Green,” which is also known as Wilson Park. The event features costumed performers
NMSU research centers celebrate fall with outreach events
NMSU agricultural science centers hosted fall learning events featuring farm demonstrations, pumpkin patches and hands-on activities for elementary students.
‘We’re all on the same team": Dem Senator on getting moderate voters behind progressive Senate candidate Abdul El-Sayed
Scientists discover how pancreatic cancer rewrites its DNA to escape treatment
Scientists have discovered how pancreatic cancer cells continually reshape their genetic makeup to become more aggressive, spread, and evade treatment. In laboratory experiments, blocking a key gene reversed some of these dangerous changes, revealing a potential new way to fight the deadly disease.
Finding biomarkers for aggressive prostate cancer
Proteins linked to the immune system, cell adhesion, blood vessel formation, and known prostate cancer genes, were associated with the future risk of developing prostate cancer, including aggressive disease, in a new study led by researchers at Oxford Population Health.
Obama jokes about the ‘well-known evil empire, Canada’
Former President Barack Obama expressed astonishment as he condemned President Donald Trump’s tariffs on Canada during a rally in support of Michigan’s Democratic Senate nominee Abdul El-Sayed in Detroit, Michigan on Saturday.
Skip Bayless Has Bold Vikings Declaration After Bears Win
Skip Bayless doubled down on his belief that the Minnesota Vikings will win the NFC North despite the Chicago Bears’ recent victory, keeping the division race firmly in the spotlight. The outspoken sports commentator’s prediction signals that he remains confident in Minnesota’s chances as the NFC North contenders continue to battle for position. The Bears’ […] The post Skip Bayless Has Bold Vikings Declaration After Bears Win appeared first on Gridiron Heroics.
Barack Obama rallies Michigan crowd for El-Sayed, saying he’s ‘fighting for real change’
Former president speaks to rapturous crowd of thousands in support of Democrat Abdul El-Sayed for US Senate
Sacha Baron Cohen says 'Ali G: Who Iz I?' is his last in this style of comedy, calling them too risky
Sacha Baron Cohen reveals why "Ali G: Who Iz I?" will be his last over-the-top comedy, citing dangerous stunts and severe dehydration on set.
Obama compares Trump's White House renovations to 'Saddam Hussein opening a Cheesecake Factory' at Ohio rally
Barack Obama compared Trump's White House renovations to a Cheesecake Factory run by Saddam Hussein at a Cleveland rally for Ohio Democrats.
How hot you drink your tea may affect heart health
A study of more than 485,000 adults in China found links between tea-drinking habits, tea temperature and the risk of heart and blood vessel disease.
Kinney Drugs offers free caregiver webinar series
Kinney Drugs will host four free caregiver webinars Oct. 28-Nov. 18 covering dementia, burnout, medication safety and caregiving tips. Registration is open.
Obama, in Ohio, assails 'cruelty' from Trump in campaign
Former President Barack Obama has stepped into one of America's ugliest midterm fights as he works to rally Democratic voters in battleground Ohio.
Man dead after running into Meriden business for help following stabbing
Police believe the stabbing incident likely occurred on Pratt Street on or near the Green.
In first midterm rally, Obama blasts Trump administration
Democrats have embraced the former president as their most effective closing messenger in the final weeks of the high-stakes midterm campaign.
Voters in 2 Democratic strongholds could ban transgender girls from girls school sports
Colorado and Washington are reliably Democratic states where elected officials have rejected moves to ban transgender women and girls from female sports competitions. Now activists have gone around lawmakers to put proposed bans on both states’ ballots.
Obama describes Trump as an agent of ‘chaos and cruelty’ in midterm elections pitch
The former president on Saturday also criticized Republican Vivek Ramaswamy’s attack ad featuring the estranged mother of Amy Acton, his Democratic rival for governor.
‘Optimus Prime: Awakening’ review: Peter Cullen delivers an emotional performance | Texas A&M University-San Antonio
“Optimus Prime: Awakening” is a 12-minute short film that was screened alongside the 40th anniversary theatrical re-release of “The Transformers: The Movie.” Released in 1986 after the first two seasons of the animated series, “The Transformers: The Movie” returned to theaters in 2026 as part of Hasbro’s yearlong “Apology Tour.” The marketing campaign celebrated the...
Barack Obama to rally for Abdul El-Sayed in Michigan ahead of key US Senate race
The former Democratic president is showing major support in Detroit for the progressive Michigan candidate in final days before US midterm elections
Leland Fall Festival brings trick-or-treating, live entertainment to Founders Park
The Town of Leland is inviting families to celebrate the fall season with a free festival featuring trick-or-treating, live entertainment and activities for all ages.
LIVE! Watch UFC 333 Post-Fight Presser
With UFC 333 officially a wrap after an entertaining card earlier today (Sat., Oct. 24, 2026) LIVE on Paramount+ from inside Etihad Arena in Abu Dhabi, United Arab Emirates, fight fans can now check out the post-fight press conference video above for all the best reaction and official bonus winners. On a day that featured […]
Lt. Gov. Juliana Stratton campaigns in Quincy, touts health care plan
Lt. Gov. Juliana Stratton spoke to the crowd about health care and the cost of living for Americans. She said her campaign funding will not come from larger corporations.
An electronic health record tool for exercise prescription may reduce fall rate among older adults
In a large randomized clinical trial among 22 primary care practices, use of an electronic health record-integrated clinical decision support tool known as…
In Senate run, Juliana Stratton touts progressive politics and a pragmatic record
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Netflix’s Leadership Shake Up…Explained
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) Well, I had a simple article planned for this week. Called “Whoa, I Missed It!”, I’d take a gander at a few important-but-under-the-radar stories I didn’t cover while I wrote about all things “Skydance. (Formerly known as “the saga of Netflix trying to buy Warner Bros., but not Discovery, then Paramount-Skydance bought all of Warner Bros. Discovery”.) Alas, that article will have to wait. Netflix made news. Ironically, my “Whoa, I Missed It!” article would have mostly been about “content” strategy decisions, which is also what today’s article is about. But instead of the entire industry, this article will only cover Netflix’s decision to upend their film and TV content teams. Just that! So that’s the full topic of the day. I’m going to tackle the issue in the opposite direction of the way “stuff” flows: uphill. We’ll start at film, then move onto TV, and then onto the CEOs themselves, and the strategy questions that still remain. But we start with the numbers driving this. Let’s dive in. Subscribe Most Important Story of the Week - Netflix Upends Their Corporate Hierarchy I’ve got a lot of thoughts, but we’ll start with the most common response to yesterday’s article. Let’s Talk Stock Price More than one person, responding to what I published two days ago, pointed out that, well, actually, the thing driving Netflix’s actions is this: In short, stock price! Even if Netflix isn’t obsessed with their own share price—they probably are, but, for the record, my strategic advice to every CEO is to absolutely ignore stock prices, which will, ironically, probably help the stock price long-term—most everyone thinks they are. By the way, I prefer market capitalization to stock prices, because it’s a more apples-to-apples way to compare companies: But there’s an even better way to look at it, and it kinda casts some doubt on the entire push here: price-to-earnings. I have a long list of articles that I wish I had written, and chief among them is an article titled, “Am I Still a Netflix ‘Bear’?” meaning someone who thinks Netflix’s stock is overvalued. As of last summer, Netflix had solved their biggest problem—which for me (circa 2019) was the lack of free cash flow—but their stock was CRAZY overvalued. That’s this chart here: Why did Netflix’s stock price increase to a price-to-earnings ratio of 50 last summer? What financial metric changed so quickly? Nothing. Given that, historically, mature entertainment companies average 10 to 20, with 16 being the average, that increase made little sense. Netflix’s stock swoon these last eight or so months wasn’t irrational; the stock price rise last year was. So if you want a really hot Netflix take, here it is: Netflix’s stock price has been going down because the financial industry recovered its senses, not because of any strategic mistake. Yes, that would imply that cleaning house may have been a mistake. That’s why the charts yesterday are so important, because they show that Netflix did have a strategic problem (a lack of hits) and that’s what they moved to address. (One could also argue the industry drastically overrated Netflix’s growth prospects, but that’s a financial industry problem, not a Netflix strategy problem per se. Some growth estimates are just crazy. *cough* AI *cough*) Now, the last time Netflix’s stock price crashed—circa 2022—it gave them an opening. I’d argue Netflix insiders knew they needed to expand post-COVID-19 crisis, adding advertising, cracking down on password sharing, and dabbling in sports. But if they had done that when their stock price was high, it would give folks a reason to second guess their strategy. (Arguably, last year, when Netflix pursued the Warner Bros. merger, it gave the industry a chance to review their business.) Instead, after the 2022 fall, they had the opening to make strategic changes. We may see Netflix pivot again following this latest slide. For example, the “binge versus weekly” conversation is alive and well again. Same for expanding into theaters even more. And adding both linear channels and streaming bundles. And maybe more either social, user-generated, vertical, or creator content. But the first shift came with who is making the content calls. A Message from Our Sponsor Last winter Pulp Fiction was on Netflix. For those same 90 days, it was also free, with ads, on Pluto TV and the Roku Channel. That is not a glitch, and it is not rare. The title has run on 20 different US streaming services since 2019, across 80 separate windows, and for more than 600 of those days it sat on a paid subscription service and a free ad-supported one at the same time. Almost nobody can see this, because when a title leaves a service, the record that it was ever there tends to leave with it. Reelgood keeps that record, dated to the day rather than the month: 4MM+ movie, show and episode titles across 300+ services globally, with timestamped arrivals, departures and moves across SVOD, AVOD, TVOD and vMVPD. Licensing teams price against every prior window. Rights teams check what a licensee actually delivered, and when. Pick a title you think you know: data.reelgood.com/title-availability Film - Dan Lin Want to know why I don’t opine on individual film or TV executives, especially new hires? Dan Lin. As I always caution, it’s really, really, really tough to predict which executives will succeed in new roles and which won’t. The successful head of co-production/finance partner, Rideback, Lin was considered for the head of DC Studios job before taking the job as the head of Netflix. By all accounts at the time, this was a smart hire. (That’s my read of the news coverage anyways.) But now that Netflix has fired Dan Lin, we got a slew of news stories about how he was doing a terrible job. In sports media, Bryan Curtis, new Substack writer/podcaster from The Ringer, calls this the “now you tell us” story, when you only hear the bad news after a star athlete leaves a sports team. In this case, now they tell us that Dan Lin was bad with talent after he got kicked out the door. So was Dan Lin a flop? It’s actually tough to say. While film moves faster than TV, even two years isn’t really enough time to evaluate a person’s output. The new head hasn’t really taken control. As Emily Horgan noted, it takes much longer than two years to produce animated films, so yeah, it’s definitely too early to judge in that domain. As for live-action films, I just published an article by Brandon Katz called “Netflix’s Summer of Bummer”, but I’d point out Netflix had a bad summer two years ago too. Arguably, their best summer came from KPop Demon Hunters last year and Happy Gilmore 2, the latter of which I saw credited to Lin. Then, the stories came out that Dan Lin clashed with talent, both Ben Affleck and Greta Gerwig, classic “now they tell us” factoids to explain his firing. This may have been true, but also should have been expected given that he was given the mandate to bring budgets back in check, especially after Rebel Moon. So if he made folks upset, well, that’s what he was hired to do! But also, he was described as “well-liked” at his hiring! In that case, I’m a bit sympathetic to Lin, since he may have been undercut by senior leadership, as often happens. Basically, a CEO hires a subordinate to be their “bad cop” and keep budgets in check, but then when talent complains, the CEO ends up undercutting them. That’s how I think you end up with a Narnia movie as expensive as any of the other flops, along with a film executive the town no longer likes. As a result, I think that Netflix is now executing a classic “hire the opposite” move by hiring Peter Rice. This phrase comes from my experience following football and basketball coaching decisions, where teams generally hire the opposite of who they just had. If you have an offense-minded head coach, hire the defensive guy. Or in college football, if you have a strong recruiter, then you pivot to an “X’s and Os” type of guy. Or in pro basketball, if you have a very analytically minded coach, you hire the player-friendly guy. I see that here. After dropping Scott Stuber—arguably a talent-friendly executive with lax budget control—Netflix hired the business guy to keep costs in check. Now Netflix is pivoting back to Peter Rice and presumably a more talent-friendly regime. (Disney, by the way, has done this twice: hiring business guys to succeed talent-friendly Bob Iger. It didn’t work out last time.) When it comes to Peter Rice…we’ll see! Maybe he works out, but maybe he doesn’t. I’d actually say the biggest problem is that Netflix still hasn’t solved its “IP Problem”, in that they don’t own much IP, so they just have a lower hit rate. The new executive won’t solve that. (Though buying Lionsgate would help.) Share “Content” - Bela Bajaria I almost published yesterday’s article after this column, but ended up flipping the order, because it told the story so well. So if you want the data for why Netflix is looking at TV to fix their problems, it’s in that article, this graph in particular: I know I just wrote that it’s often hard to judge executives, but Bajaria ran TV for six years and film for three and a half more. That’s more than enough to judge hit rates, and Netflix needs more hits. That’s the story. Since 2023, Netflix hasn’t had as many hit shows as it used to, and many of its previous power house TV shows have ended their runs (Stranger Things most of all). Also, many shows from 2020 to 2022 probably pre-dated Bajaria’s tenure. (That said, one thing may have been outside of Bajaria’s control, which I explain below.) Let’s lump some content strategy thoughts about Netflix and TV into one place: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why I partially blame Squid Game for Netflix’s latest troubles… What is “the football trap”... Why it might not be the TV shows or films’ fault at all… What change I don’t think Netflix will make... How Bela Bajaria evolved Netflix’s TV strategy in smart ways… Whose departure likely submarined Bajaria’s final few years… One sneaky explanation for Netflix’s content struggles... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support.