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Roob's Observations: Can Jihaad Campbell make the Eagles forget Nakobe Dean?
The most intriguing story of training camp, whether the Eagles have enough at safety and more in this edition of Roob’s Random Offseason Observations.
Seahawks Issued Intriguing Najee Harris Take Amid Training Camp
The Seattle Seahawks head into the 2026 NFL season as the defending Super Bowl champions, but they still have a few concerns as they try to repeat. One of the biggest questions surrounds the team’s running back group.Kenneth Walker III departed in free agency this offseason, signing with the Kansas City Chiefs, while Zach Charbonnet […] The post Seahawks Issued Intriguing Najee Harris Take Amid Training Camp appeared first on HEAVY.
Packers Get Intriguing Diego Pavia Message After Ravens Release
One analyst believes Matt LaFleur could be the right coach to revive another young quarterback. The post Packers Get Intriguing Diego Pavia Message After Ravens Release appeared first on HEAVY.
Philadelphia Eagles Get Linked to Intriguing Browns Trade Target
Going into the 2026 NFL season, the Philadelphia Eagles‘ biggest question marks will be on the offensive side of the ball. After dominating in the Super Bowl two seasons ago, the defensive side of the clear was by far the strongest for Philadelphia in the following season and it wasn’t particularly close. But with that […] The post Philadelphia Eagles Get Linked to Intriguing Browns Trade Target appeared first on HEAVY.
Vikings May Have Found Next Hidden Gem in Undrafted Rookie
The Minnesota Vikings have several intriguing players as they head into training camp. Of course, veterans such as Justin Jefferson and Kyler Murray will take all the major headlines. However, one undrafted free agent is creating buzz as well. Wide receiver Dillon Bell is turning heads with training camp on the horizon.Bell was signed by […] The post Vikings May Have Found Next Hidden Gem in Undrafted Rookie appeared first on HEAVY.
Texas Makes Announcement Featuring Arch Manning
The college football season is approaching quickly, and the Texas Longhorns are one of the most intriguing teams entering 2026.Head coach Steve Sarkisian has assembled a roster loaded with talent. However, quarterback Arch Manning remains the team’s biggest storyline as he enters his fourth season with the program.This will be just Manning’s second year as […] The post Texas Makes Announcement Featuring Arch Manning appeared first on HEAVY.
Jeff Passan Just Dropped Nightmare Dodgers-Tarik Skubal Take
Tarik Skubal is Major League Baseball's most intriguing trade candidate.
MLB World Reacts To San Francisco Giants Drafting Intriguing Pitcher
On Saturday, the San Francisco Giants played the third game of their series with the Colorado Rockies at Oracle Park.They won by a score of 4-2.MLB World Reacts To SF Giants Drafting PitcherAlso on Saturday, the Giants selected Carson Bolemon in the first round of the 2026 MLB Draft.SFGProspects wrote: “With the 29th pick in […] The post MLB World Reacts To San Francisco Giants Drafting Intriguing Pitcher appeared first on HEAVY.
Who is the Commanders' most intriguing newcomer?
Of all the free agents the Commanders signed, an offensive addition was named the most intriguing newcomer.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
Malik Willis Has 6 Career Starts and CBS Sports Just Ranked Him Among the NFL's Most Intriguing QBs
The NFL is a pass-heavy league, and teams rely on aerial attacks and high-scoring offenses not just to win games, but to contend for a Super Bowl championship. "After rejuvenating his career in Green Bay, Willis will get his first legitimate chance to be an NFL starting quarterback," DeArdo wrote. "It'll be a challenge, though, as Willis is joining a Dolphins team that is starting anew."
Phoenix Suns Could Have Intriguing Trade Chip at Center
Phoenix Suns center Mark Williams signed a contract that is "very tradeable," according to one insider.
Colombia vs. Portugal scenarios, explained: How final Group K game will impact 2026 World Cup bracket
Colombia and Portugal clash in one of the most intriguing games in the final round of group-stage matches at the World Cup.
Report: Pacers Targeting Guard in Second Round of NBA Draft
The Indiana Pacers are reportedly targeting an intriguing guard in the second round of the 2026 NBA Draft.
New York Giants 2026 training camp position battle to watch
Which starting job up for grabs is the most intriguing during the New York Giants' 2026 training camp? Find out here.
New England Patriots 2026 training camp position battle to watch
Which starting job up for grabs is the most intriguing during the New England Patriots' 2026 training camp? Find out here.
Famous Pink Planet Mystery Decoded: JWST Says Salt Clouds are the Culprit
This Magenta world's strange atmosphere made no sense until JWST found intriguing clouds made of salt.
Kansas City Chiefs 2026 training camp position battle to watch
Which starting job up for grabs is the most intriguing during the Kansas City Chiefs' 2026 training camp? Find out here.
Cleveland Browns 2026 training camp position battle to watch
Which starting job up for grabs is the most intriguing during the Cleveland Browns' 2026 training camp? Find out here.
Earth Might Have Been Sprinkling Europa With Life Since Before Animals Existed
Hundreds of sextillions of dust grains may have escaped Earth and reached Europa, raising intriguing questions about the possible transfer of life through space.
Colorado primary for U.S. Senator: Candidates John Hickenlooper and Julie Gonzales
The race between U.S. Sen. John Hickenlooper and state Sen. Julie Gonzales has emerged as one of Colorado’s most intriguing Democratic primaries. Gonzales is running on a message of generational change, arguing that Democrats need a more aggressive approach and that a vote for Hickenlooper will just mean “more of the same.” Hickenlooper, a fixture […]
5 most intriguing non-division games on the Cowboys schedule
What non-division game are you looking forward to the most?
This popular brain supplement was linked to shorter lifespans in men
A large-scale study suggests that men with higher levels of the amino acid tyrosine may have shorter lifespans, potentially losing close to a year of life expectancy. The finding is especially intriguing because tyrosine is commonly associated with brain health and is often used in supplements aimed at boosting focus and performance.
Vampires, literary monsters and a cake: The Tony Awards offer a number of intriguing, possible wins
The Tony Awards are set to celebrate Broadway's best, with 24 shows vying for wins across 26 categories.
Vampires, literary monsters and a cake: The Tony Awards offer a number of intriguing, possible wins
The Tony Awards are set to celebrate Broadway's best, with 24 shows vying for wins across 26 categories. Grammy winner Pink hosts the event, airing live on CBS and streaming on Paramount+ on Sunday...
Vampires, literary monsters and a cake: The Tony Awards offer a number of intriguing, possible wins
The Tony Awards are set to celebrate Broadway's best, with 24 shows vying for wins across 26 categories
Vampires, literary monsters and a cake: The Tony Awards offer a number of intriguing, possible wins
The Tony Awards are set to celebrate Broadway's best, with 24 shows vying for wins across 26 categories.
Patriots scouting report: Karon Prunty offers some intriguing tools
Previewing the Patriots cornerback heading into his first NFL season.
Izaiyah Nelson mocked to Suns
Izaiyah Nelson is an intriguing prospect for the Phoenix Suns if they hold steady with the 47th pick in the 2026 NBA Draft.
CFB analyst provides intriguing prediction for Texas A&M's 2026 season
Popular X account CFB Home predicts Texas A&M to finish 10-2 in 2026, with both losses coming at the end of the year.
Barcelona battling Atletico Madrid for three blockbuster signings this summer
Barcelona and Atletico Madrid appear to be heading towards one of the most intriguing transfer battles of the summer, with both clubs targeting several of the same high-profile players ahead of the ne...
Nottingham Forest Eyeing Move for €45m Juventus Forward
Nottingham Forest Transfer News: Lois Openda Emerges as Intriguing Summer TargetForest Eye Openda OpportunityNottingham Forest’s summer planning has taken an intriguing turn, with Gianluca Di Marzio...
2026 K League 2 Round 15 Preview
The final round before the World Cup break brings several intriguing storylines across the K League 2. In-form Hwaseong FC put their eight-match unbeaten run on the line against promotion contenders S...
Brentford Set to Stun Premier League With £38m Summer Transfer
Brentford Transfer News: Said El Mala Deal Signals Serious AmbitionBrentford Move Closer to Said El Mala TransferBrentford appear to be edging towards one of the most intriguing deals of the summer, w...
Inside California Politics: Final Emerson poll sets up intriguing election day
(Inside California Politics) — A new poll released just days before polls close in California’s gubernatorial primary show a tight race with three candidates competing for just two spots in t…
Intriguing defensive lineman commits to FSU football
The FSU Seminoles have landed a commitment from three-star defensive lineman Eric Vaulx Jr., their first defenisve line commit in the 2027 cycle.
The best new science-fiction books of June 2026
There is plenty of intriguing sci-fi on offer this month, whether it’s solar-powered cities from Adrian Tchaikovsky or a strange future from M. John Harrison
Twisted graphene reveals a hidden superconductivity switch
Scientists have uncovered a surprising new way to control superconductivity — the mysterious phenomenon where electricity flows with zero energy loss. By pairing twisted layers of graphene with a synthetic diamond material, researchers were able to effectively switch superconductivity on and off by tweaking how electrons interact with their surroundings. Even more intriguing, the material behaved in ways that defied the rules of conventional superconductors, hinting at an entirely new kind of physics.
Vikings’ Jauan Jennings Makes Surprising Kevin Durant Comparison Amid OTAs
Jauan Jennings dropped an intriguing Kevin Durant comparison for how he feels as part of the Vikings receiving corps.
25 intriguing Eagles to watch at 2026 OTAs and minicamp
Here are 25 Eagles we’ll be watching this week as Eagles kick off their Organized Team Activities.
Denver Broncos roster review: Cornerback Brent Austin
Undrafted rookie free agent cornerback Brent Austin has an intriguing skillet, but can he earn a spot on the Broncos’ final 53-man roster?
Scientists reveal how seven days of fasting transforms the human body
Scientists have discovered that the human body undergoes a dramatic internal transformation during extended fasting, with major changes appearing only after about three days without food. In a seven-day water-only fasting study, researchers tracked thousands of proteins in the blood and found widespread shifts affecting organs throughout the body — including the brain. While the body quickly switches from burning glucose to fat, the most intriguing biological changes linked to potential health benefits didn’t emerge until later in the fast.
Ranking the six most intriguing games on the Broncos schedule
The Broncos have plenty of intriguing games in 2026, but these six pack more of the intrigue punch than the rest.
Scientist's intriguing new theory on Great Pyramid — and how it could be used to communicate with the cosmos
When ET phoned home, was he using the Great Pyramid?
2026 Phillies Draft Preview Jared Grindlinger, LHP/OF
I always like to start previews with my favorite prospect. That’s often someone the Phillies have no chance at, but not this year. A reclassicification of draft eligibility made this year’s mystery box my favorite, most intriguing option. Grindlinger is a left handed Outfielder and Pitcher and is a potential 1st/2nd rounder in both roles. […]
Five intriguing Phillies prospects raking down on the farm
The Phillies’ farm system has featured several strong offensive starts, including breakout showings from Alirio Ferrebus, Bryan Rincon and Dante Nori.
Should the Tennessee Titans sign DB Kenny Moore II?
Kenny Moore II is an intriguing free agent with a connection to the Tennessee Titans’ coaching staff.
Scientists discover a new way to prevent gum disease without killing good bacteria
Scientists have uncovered a surprising way to influence the bacteria living in our mouths — not by killing them, but by interrupting how they “talk” to each other. Researchers found that dental plaque bacteria use chemical signals to coordinate growth, and by blocking those signals, they were able to encourage healthier bacteria while reducing disease-linked microbes tied to gum disease. Even more intriguing, the bacterial conversations changed depending on oxygen levels above and below the gums, revealing an entirely new layer of complexity inside the mouth.
Could MotoGP Be Headed to Miami?
With MotoGP continuing its global expansion push, the idea of a race in Miami, Florida, is becoming an increasingly intriguing possibility — even if it’s not on the immediate horizon. While we’ve seen reports of MotoGP execs meeting with F1 Miami organizer South Florida Motorsports, there’s little to go on, but the possibility is still worth expounding upon.
Bulldog hoops lands former juco star Perry from BYU
(KSEE/KGPE) – The losses have been heavy in the transfer portal recently for the Fresno State men’s basketball team, but the roster rebuild got a big boost Monday, as the program’s head coach Vance Walberg announced the signing of a very intriguing prospect, K.J. Perry from BYU. Perry was a highly-touted junior college recruit, who […]
New QB1 in AZ? Why Cardinals should give Carson Beck chance to start
Jeremiyah Love is the best player the Cardinals drafted, but Carson Beck is the most intriguing. Arizona should give him a chance to earn the starting spot.
This “quantum” material fooled scientists and revealed something new
A mysterious magnetic material once thought to host an exotic “quantum spin liquid” has turned out to be something entirely different—and possibly just as intriguing. Scientists studying cerium magnesium hexalluminate found it showed the hallmark signs of this elusive quantum state, like a lack of magnetic order and a spread of energy states. But after closer inspection using neutron experiments, they discovered the behavior came from a delicate tug-of-war between two opposing magnetic forces.
Guess What This Creepy Underwater Thing Is That Was Photographed by US Navy Divers for NASA
An intriguing photo shows the charred heat shield of NASA's Artemis 2 Orion capsule right after splashdown in the Pacific on April 10.
Clemson 2026 NFL Draft Player Preview: Adam Randall
Position: RB Height: 6’3” Weight: 232 40 yd Dash: 4.5 Shuttle Time: Unavailable Vertical Jump: 37” Broad Jump: 10’4” Bench Press: 26 reps College Performance: One of Clemson’s more intriguing players in the draft, Adam Randall started life at Clemson as a WR before converting to RB late in his career. His time as a […]
Intriguing running back draft prospect has Jaguars' attention
An intriguing running back prospect has the Jacksonville Jaguars' interest ahead of the 2026 NFL draft.
‘Seeking connection’: the video game where players stopped shooting and started talking
In a post-apocalyptic landscape of cutthroat scavengers, surprisingly peaceful players are opting to team up and open up – a phenomenon that’s intriguing game developers and psychologists alike
Can WR prospect with question marks fix 49ers WR corps?
The San Francisco 49ers have added two veterans wideouts to their room, but now they're looking at intriguing prospect in the 2026 NFL draft.
The underworld invades Sutter Street Theatre
FOLSOM — "Hadestown: Teen Edition," an intriguing and beautiful folk opera, delivers a deeply resonant and defiantly hopeful theatrical experience. The full-length adaptation of Anaïs Mitchell’s "Hadestown," modified for performance
What Sea Creatures Reveal About How Fast People Age
By Carole Tanzer Miller HealthDay ReporterSUNDAY, April 5, 2026 (HealthDay News) — This is no ordinary fish story. Researchers who videotaped every moment in the lives of 81 African turquoise killfish gleaned intriguing insights into the aging process that may also apply to humans. Though killfish ...
2026 NFL Draft Profile: Michigan edge rusher Jaishawn Barham
Michigan standout Jaishawn Barham would be an intriguing draft day addition for the Denver Broncos.
The safest pick, biggest gamble and more 2026 NFL Draft superlatives
From best players to buy-low candidates and potential Day 2 steals, a breakdown of this class's most intriguing prospects.
Seven most intriguing offensive additions during the 2026 NFL free agency period
Kyler Murray joining Kevin O'Connell with the Vikings, plus more interesting offensive moves
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
For decades, no one listened to him… today his theory about the origin of life is intriguing scientists - Futura-Sciences
When Tibor Gánti passed away at the age of 75 on April 15, 2009, he remained largely unknown. Much of his career unfolded behind the Iron Curtain, which divided Europe for decades and limited the exchange of scientific knowledge. While his theories gained some attention during the communist era, today...
Nine most intriguing defensive additions during 2026 NFL free agency so far
Can Minkah Fitzpatrick and T'Vondre Sweat help reboot the Jets defense?
Scientists tested vitamin D for COVID and found an unexpected long COVID clue
A major clinical trial has delivered an unexpected twist in the search for ways to fight COVID-19 and its lingering effects. Researchers at Mass General Brigham found that taking high doses of vitamin D3 did not make COVID-19 infections less severe or reduce hospital visits. However, the study uncovered a subtle but intriguing signal suggesting that people who consistently took vitamin D supplements might be slightly less likely to develop long COVID symptoms weeks after infection.
A “ghost” great white shark just reignited a Mediterranean mystery
A rare encounter with a juvenile great white shark caught by fishermen in April 2023 has reignited scientific interest in the mysterious population of these apex predators in the Mediterranean Sea. By reviewing records spanning more than 160 years, researchers found that great whites still appear sporadically in Spanish Mediterranean waters, suggesting the population—though elusive and declining—has not vanished. The discovery of a young shark raises an intriguing possibility: these legendary predators may still be reproducing in the region.
Samsung wants Galaxy S26 Ultra’s Privacy Display users to stay cautious
Samsung has released some of the important notes about the Galaxy S26 Ultra’s Privacy Display feature, which you should know before you buy this phone based on its intriguing promos and advertisements. The privacy display feature allows you to hide the on-screen content from other people while using the phone in public or crowded places. […]
Weapons for Drake Maye: Patriots have options to replace Stefon Diggs
How can the Patriots upgrade their WR room after parting with Stefon Diggs? Phil Perry identifies a handful of intriguing names.
Ranking NFL free agent tight ends: Proven vets, intriguing younger options available, but no true stars
Tight end usage rose in 2025, and several players are looking to take advantage.
ESPN poses intriguing question to Vikings over J.J. McCarthy's future
Will 2026 be McCarthy's show?
Matthew Berry’s 35 Most Interesting Things He Heard At 2026 NFL Combine
Matthew Berry reveals the 35 most interesting things he heard at the NFL Combine from a dizzying QB carousel to intriguing RB moves.
Bournemouth vs Sunderland – Match preview and team news
The Vitality Stadium plays host to an intriguing early kick-off on Saturday as one of the Premier League’s most consistent sides, Bournemouth, looks to deepen the misery of a sliding Sunderland.The ...
The Winter Olympics' most intriguing sport is thriving in the Bay Area
Some call it a "goofy side quest." Others call it an Olympic sport.
Lions Give Packers More Offseason Entertainment with New Drama
The early stages of the NFL offseason have been quite busy and intriguing for teams in the NFC North. The Green Bay Packers, Detroit Lions, Minnesota Vikings, a
Daytona 500 Live Updates, Leaderboard: Who Will Win 'Great American Race?'
The biggest NASCAR race of the year has arrived, and this year's Daytona 500 is full of intriguing and exciting storylines. Stick around here for live updates from Sunday's race.
We still don't know why curling stones move the way they do
The icy ballet of stone upon ice makes curling one of the most intriguing sports of the Winter Olympics. But scientists still haven't quite figured out the physics of how they move.
We still don't know why curling stones move the way they do
The icy ballet of stone upon ice makes curling one of the most intriguing sports of the Winter Olympics. But scientists still haven't quite figured out the physics of how they move.
Sooo ... About Last Night
Last night (Sat., Feb. 7, 2026), Ultimate Fighting Championship (UFC) returned home to the Meta APEX in Las Vegas, Nevada for UFC Vegas 113. Luckily, the first “Fight Night” event of 2026 was a step up from the average APEX affair. There were intriguing bouts booked throughout the evening featuring some quality prospects and familiar […]
Phillies invite 2 intriguing players to spring training
As the Phillies craft their 2026 plans, two non-roster invitees will have an opportunity to prove themselves at spring training.
“Déjà vu”: what scientists have discovered is even stranger! - Futura-Sciences
Human memory still holds many mysteries. While déjà vu is a relatively well known experience, its lesser known counterpart, jamais vu, remains largely unfamiliar to the general public. Yet this intriguing cognitive phenomenon could teach us a great deal about how our brain works. A recent study, published in September...
Discovering Optima Health And 2 Other Promising UK Penny Stocks
The UK market has recently experienced some turbulence, with the FTSE 100 index closing lower amid weak trade data from China, highlighting ongoing global economic challenges. Despite such fluctuations, investors often look beyond blue-chip stocks to explore opportunities in smaller or newer companies that can offer unique value propositions. Penny stocks, a term that might seem outdated but still relevant today, represent these potential investments; they can provide intriguing prospects...
Patriots’ Potential Next Playoff Opponent Revealed After Bills-Broncos Thriller
The New England Patriots still need to win in their divisional round matchup with the Houston Texans on Sunday. It’ll be quite intriguing if they can take care of business, however… New England is just one victory away from visiting the one-seed Denver Broncos at Empower Field at Mile High in the 2026 AFC Championship […]
14 things to do in the Wilmington area this weekend
It's shaping up to be a pretty epic weekend in the Wilmington area, with lots of intriguing entertainment options.
Sleek New Android Phone Comes With Features Google's Pixel Can't Match
There's a new, affordable Android phone coming out in 2026 that has a host of intriguing features Google's Pixel 10 lineup can't match.
Axe: 5 most intriguing Syracuse sports stories to watch in 2026
Brent Axe looks forward to the stories he'll be watching out for in 2026.
Intriguing science discoveries of 2025
This year, our scientists offered new hope for treating neurodegeneration and obesity and dramatically improved the odds that a once-promising immunotherapy could still prove to be a game-changer for cancer patients. They gained new insight into the mechanics of hearing, the emergence of spoken language, and how brand new genes can arise out of […]
Intriguing Free PS5, PS4 Games Stealth Dropped on PS Store
If you're looking for something different to play this weekend, then the PS Store has a pair of free PS5 and PS4 games for you.
MLB rumors: Bellinger, Bregman unlikely to settle, plus an intriguing Murakami option
Here are Thursday's MLB rumors and moves
Nebraska QB Dylan Raiola to enter transfer portal; Oregon potential suitor
Raiola will join an intriguing QB portal class for 2026 with two years of eligibility remaining
The Astros just made an intriguing minor league ownership decision
The Houston Astros have not been very active during this year’s winter meetings, at least in the major league side of things. However, change is coming quickly for their minor league clubs.
Intriguing players to watch in Falcons vs. Seahawks
Naming five Falcons who must step up if the Falcons have a chance to upset the Seahawks
Fruitcake, Savory Soups, and Entertainment
SUNDAY December 7, 2025 {READ IN BROWSER} FEATURE Corsicana: Your Adventure Awaits One of the Corsicana’s most intriguing aspects is its bronze statue tour, a life-sized art exhibit telling stories about the unique individuals who shaped its history. Created by different artists, most of the lifelike sculptures interact with the cityscape: an oil field worker…
Kirsten Dunst Intriguingly Teases Role In Ruben Östlund’s ‘The Entertainment System Is Down’: “I Bared A Part Of Myself”
Kirsten Dunst Intriguingly Teases Role In Ruben Östlund’s ‘The Entertainment System Is Down’: “I Bared A Part Of Myself”
Former Towne West Square mall lands first major tenant as business park transformation advances
The business park is an "intriguing project" that will help revitalize the area, said Nathan VanderGriend, CEO of PROtect, which has 22 locations with more than 750 employees in the
The best new science fiction books of December 2025
From a new collection of shorter fiction by Brandon Sanderson to Simon Stålenhag’s new work, via a Stranger Things novel, December’s new sci-fi features some compelling and intriguing offerings