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Less sleep = less health; Led Zeppelin in the OR; dangers of people-pleasing; plus other stories with Vanderbilt Health sources
Prevention interviewed Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, for a story about two randomized trials published in Annals of Internal Medicinethat found decreasing sleep by just 1.5 hours each night was linked with increases in body weight, waist circumference, and sedentary time in adults with elevated cardiometabolic risk. Yahoo Healthalso picked up the story. WTVF News Channel 5 reporter Nikki Hauser interviewed Ashish Shah, MD, Professor and Chair of Cardiac Surgery, for a new video podcast series called “Why Nashville” where she interviews interesting people doing interesting work about why they came to Nashville and how it is going. Among the revelations: his go-to OR music includes Led Zeppelin and AC/DC. Everyday Health interviewed Aaron Brinen, PsyD, Assistant Professor of Psychiatry and Behavioral Sciences, for a story about the TikTok trend that encourages women to speak up about their concerns or they’ll develop an autoimmune disease. Overall, people suggest that suppressing feelings of anger, minimizing your own needs, or people-pleasing raises your risk. Telemundo Nashville broadcast a story on cyclosporiasis that quotes both William Schaffner, MD, professor of Preventive Medicine, and Juan C. Salazar, MD, MPH, chair of the Department of Pediatrics and system Pediatrician-in-Chief for Monroe Carell Jr. Children’s Hospital at Vanderbilt. Schaffner also spoke to WKRN News 2 about measles and The Cutabout shingles and long distance running. WREG (Memphis) and others picked up the measles story as well. CNN reporter Deidre McPhillips interviewed John Trahanas, MD, Assistant Professor of Cardiac Surgery, and Director of Thoracic Aortic Surgery, for a story about aortic dissection in last week’s death of U.S. Sen. Lindsey Graham. The Nashville Post published a story by freelance reporter Leah Hunter on robotic surgery, including a patient story and numerous quotes from Sekhar Padmanabhan, MD, Assistant Professor of Surgery in the Division of Surgical Oncology.
15 things science says about friendship and what it does to your health
From immune function and blood pressure to brain scans and life expectancy, here is what researchers have found about the ways friendship shapes the body
15 things science says about friendship and what it does to your health
From immune function and blood pressure to brain scans and life expectancy, here is what researchers have found about the ways friendship shapes the body
Acute kidney injury after TAVR: Simple biomarker helps cardiologists identify high-risk patients
The CALLY index, a biomarker that examines systemic inflammation, immune system activity and nutrition, could provide care teams with significant value.
AB Science ends three studies in multiple sclerosis, other immune conditions
The trials, which were testing the tyrosine kinase inhibitor masitinib, had previously been paused. AB Science’s decision not to resume them was a matter of prioritization, not safety, the biotech said.
This ultrasound treatment may help stop arthritis before it starts
A simple, non-invasive ultrasound treatment could one day help injured joints heal instead of remaining trapped in a cycle of damaging inflammation. Researchers at The University of Alabama in Huntsville found that continuous low-intensity ultrasound encouraged key immune cells called macrophages to shift from an inflammatory state toward one that supports tissue repair.
World Cup politics: something ugly in the beautiful game
Football at the highest level is no stranger to controversy, and World Cup tournaments are not immune to political intervention. Still, 2026 is proving to be much more than a talking point
Intestinal muscularis in health and disease
Communications Biology - The authors review the intestinal muscularis – an increasingly recognized neuroimmune interface that orchestrates gut homeostasis, contributes to disease...
Creatine doesn't just build muscle. It may also help fight cancer
Scientists have discovered that creatine may strengthen one of the immune system's most important cancer-fighting pathways by energizing dendritic cells that activate killer T cells. The promising results could eventually help make immunotherapy more effective, but they have not yet been tested in human patients.
Microbiome science merges with oncology for better cancer treatments
Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.
NYC health officials warn of Legionnaires' disease outbreak in Central Park area
New York City health officials report a surge of 23 Legionnaires' disease cases on the Upper East Side. Dr. Stephanie Widmer joins 'Fox & Friends' to detail critical outbreak warning signs and discuss biohacker Bryan Johnson's autoimmune diagnosis.
How did Bryan Johnson end up with an autoimmune disease?
What Bryan Johnson’s autoimmune gastritis diagnosis says about the limits of health tracking and longevity science.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
News of disease outbreaks can warp our brains in strange and subtle ways
The "behavioural immune system" can drive harsher moral judgement and may even contribute to xenophobia.
Every Tattoo Starts a Lifelong Immune Response. Science Is Still Catching Up
You should be aware of the risks.
After her insurer denied coverage of medication, she ended up in the ER
After switching Medicare Advantage plans, a woman with a weakened immune system got tangled in the preapproval process, which the insurance industry has vowed to improve.
Ingredion plans global Benicaros prebiotic expansion across gut and immune health applications
Ingredion highlights that its recent acquisition of the Benicaros prebiotic is a strong strategic addition to its Healthful Solutions portfolio, supporting the company’s formulation versatility alongside expansion of health-forward and clean label ingredients. The company purchased the patented prebiotic fiber, made from upcycled carrot pomace, from NutriLeads earlier this month. With the deal, Ingredion obtained full ownership of all intellectual property, trademarks, human clinical trials, and know-how related to manufacturing Benicaros.
These fat-filled brain cells may be making multiple sclerosis worse
Scientists have uncovered a surprising clue that may help explain why multiple sclerosis (MS) progresses rapidly in some people but not others. In brain tissue from patients with severe MS, researchers found large numbers of “foamy” immune cells packed with fat droplets after absorbing damaged myelin. These overloaded cells appear to switch from helping repair the brain to fueling ongoing damage and inflammation.
Scientists Discover Ultrasound May Stop Arthritis Before It Starts
A new study suggests low-intensity ultrasound can influence immune cell behavior in ways that may reduce chronic inflammation and encourage tissue repair after joint injury.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
New study suggests health damage from exposure to Ohio toxic train spill
Research finds immune systems still ‘responding to toxic chemical exposures’ related to East Palestine derailment
OHSU advances massive leap in medical science with cellular therapies
Patients are benefiting from CAR-T to treat neurodegenerative diseases, cancer, lupus and other autoimmune conditions.
FDA-approved drug may finally help immunotherapy defeat rare liver cancer
Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.
Joe Manganiello turned to shamans and pagan rituals during seven-year health battle that nearly killed him
Joe Manganiello survived multiple near-death experiences during a seven-year battle with an autoimmune-related illnesses. He opens up about it all in his memoir.
Scientists discover hidden “footprints of death” that may help viruses spread
Scientists have uncovered a surprising new twist in what happens when cells die. As dying cells break apart, they leave behind tiny “footprints of death” packed with newly discovered particles that help guide the immune system to clean up the remains. But researchers found that influenza viruses can exploit this process, hiding inside these microscopic packages and potentially using them to spread to nearby cells.
Fermented food microbiome: influence on oral and gut microbiota, and human health
Nature Reviews Microbiology - The bioactive compounds and microbial consortia contained in plant-based fermented foods support oral and gut microbiota, host immune function and metabolic...
A common vitamin could help fight one of the deadliest brain cancers
A clinical trial is exploring whether high doses of vitamin B3 could give patients with glioblastoma a better chance against the aggressive brain cancer. Scientists found that niacin may help revive immune cells that tumors shut down, allowing them to attack cancer more effectively. Early results have been promising, with patients showing significantly better progression-free survival than expected.
Buildings May Soon Have ‘Immune Systems’ That Fight Airborne Disease
Following the pandemic, the federal government is spending $150 million on new technology to ensure clean indoor air. Here’s what scientists are pursuing.
Scientists reprogram brain immune cells to fight Alzheimer’s
A newly identified molecule called OLE helped restore the brain’s immune cells to a more protective state in Alzheimer’s models. The treatment reduced toxic plaque buildup and improved memory, raising hopes for a new therapeutic approach.
As Americans tuck into supplements like their health depends on it, specialized products are displacing multivitamins
Some of today’s most popular products promise better immune, adaptogenic, anti-inflammatory, gut, skin or joint health—or combinations of two or more of the above.
11 Foods Highest in Vitamin D
The sun isn't the only source of vitamin D. Foods like eggs and fortified milks can provide the nutrient, supporting bone density and immune function.
Cancer dominates PFAS conversations — science points elsewhere
Studies link PFAS exposure to cholesterol, immune function, even bone density — findings that rarely make headlines. The cancer question remains open, and the list of what science is still […]
Meet the Researcher: Jianbin Ruan, UConn Health
Jianbin Ruan's lab studies how our immune system works at the molecular level, paving the way for better treatments
Resistance Training Appears to Restore Physical Strength, Immune Health in Frail or At-Risk Cancer Survivors
10-week exercise program erased signs of chronic inflammation caused by chemotherapy and radiation
AI-designed universal coronavirus vaccine passes first human trial
Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus family, it aims to provide protection even as viruses evolve.
How to Improve Your Gut Health (and Why It’s So Important)
Almost 40% of Americans say their daily lives are affected by their bowel habits so Dr. Trisha Pasricha, author and a director of gut-brain research, joins TODAY to break down why gut health is so important. She explains how your gut is responsible for regulating metabolism, immune health, and mood, highlights signs to know if your gut is healthy, and shares ways to improve gut health like eating more fiber.
Travel Health Tips: How to Avoid Getting Sick
Learn how to prevent illness while traveling, including cruise and flight tips, immune support, and hantavirus safety tips from health experts.
Cancer’s favorite escape trick may actually make it easier to kill
Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a different group of immune cells known as CD4+ “helper” T cells.
Vanderbilt Health study explores GLP-1 therapies to improve asthma outcomes in patients with obesity
The study is still recruiting participants. It will conclude in 2026 and provide insight for further investigations into the role GLP-1 agonists may offer in treating respiratory illnesses and overall immune responses.
Is bovine colostrum really 'liquid gold' for gut health?
Baby calves rely on it to build up their immune systems and gut. And now marketers are promoting it for humans. Here's what scientists say.
The forgotten organ that could predict how long you live
A long-overlooked organ may hold surprising clues to healthy aging and cancer survival. Researchers at Mass General Brigham used AI to analyze CT scans from tens of thousands of adults and found that people with healthier thymuses—a small immune-system organ once thought to become largely irrelevant after childhood—lived longer and had substantially lower risks of heart disease, cancer, and death.
Why cancer spreads more in middle age than in old age
Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The key appears to be a special type of immune cell that helps keep cancer dormant and prevents it from spreading.
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connections between nerve cells.
Omega-3 fish oil shows promise against type 2 diabetes
A new study suggests fish oil may help reduce insulin resistance even in people who aren't obese. In diabetic rats, omega-3 supplementation improved blood sugar levels, cholesterol, and inflammation by shifting immune cells into a more anti-inflammatory mode.
Birds navigate using ‘gut feeling’, scientists find
The liver’s iron-rich immune cells act as an internal compass that helps pigeons detect Earth’s magnetic field
Homing pigeons may use a surprising navigation mechanism
How animals navigate by Earth's magnetic field is hotly debated. New research in pigeons points to iron-laden liver immune cells as the compass.
Pigeons use their livers to sense Earth’s magnetic field
Special immune cells may be one piece of their internal compass.
Researchers block key protein that helps Parkinson’s spread through the brain
A newly identified protein called GPNMB may play a major role in helping Parkinson’s disease spread through the brain. Researchers discovered that immune cells release the protein in response to damaged neurons, creating a vicious cycle that speeds up brain cell degeneration. In early experiments, antibodies that blocked GPNMB stopped the toxic process from spreading between cells.
New depression treatment targets the immune system instead of the brain
A surprising new approach to depression treatment is showing early promise — not by targeting brain chemicals, but by calming the immune system. In a small clinical trial, researchers found that an anti-inflammatory drug normally used for rheumatoid arthritis appeared to ease symptoms in people with hard-to-treat depression, while also reducing fatigue and anxiety and improving quality of life.
Scientists discover ancient single-celled ancestors still live on in your blood
Scientists uncovered evidence that human blood cells may trace their origins back to single-celled ancestors that lived 700 million years ago. By rebuilding the evolutionary family tree of blood cells, the team revealed how today’s immune system grew from some of Earth’s earliest life forms.
Advancing CAR-T Cell Science in Lupus: Meet the First Recipients of the Lupus Research Alliance–Genentech Fund
The inaugural recipients of the Lupus Research Alliance (LRA)– Genentech Award on Immune Resetting Therapies for Lupus (LGA-IRT) are… Anne Davidson, MBBS, The Feinstein Institutes for Medical Research Chimeric antigen receptor (CAR)-T cell therapy can lead to long-lasting remission in lupus, but it is not yet clear how it works at a cellular level or […]
Scientists supercharge natural killer cells to fight aggressive cancers
Scientists at McGill University have found a way to supercharge the immune system’s natural killer (NK) cells, helping them break through the defenses tumors use to stay alive. By temporarily blocking two proteins, researchers turned these cells into far more effective cancer fighters against difficult cancers like leukemia, glioblastoma, kidney cancer, and triple-negative breast cancer.
Scientists warn popular vitamin D supplement may have a “previously unknown” downside
A surprising study suggests vitamin D2 supplements may reduce the body’s levels of vitamin D3 — the more effective form of vitamin D. Researchers found D3 not only boosts vitamin D status more efficiently, but may also play a unique role in helping the immune system fight off viruses and bacteria. The discovery is prompting scientists to rethink whether D3 should become the preferred choice for supplementation.
MIT scientists discover amino acid that helps the gut heal itself
MIT scientists have identified cysteine — an amino acid found in foods like meat, dairy, beans, and nuts — as a potent trigger for intestinal repair. In mice, a cysteine-rich diet activated immune cells that released healing signals, helping stem cells rebuild damaged intestinal tissue after radiation exposure. Researchers say the discovery could eventually lead to new dietary therapies for cancer patients suffering from treatment-related gut damage.
Students With Chronic Illness Shouldn’t Have To Choose Between Health And Education
Autoimmune conditions like lupus are more prevalent among Native Hawaiian, Pacific Islander, and Asian populations
Your Baby’s Gut Health: What Matters Most in the First Weeks of Life
A baby’s gut microbiome starts developing from the moment they’re born, and those early days can have a lasting impact on immune health and development.
Two Johns Hopkins researchers elected to National Academy of Sciences
Ulrich Mueller, Erika Pearce recognized for their groundbreaking work on hearing loss and immune metabolism, respectively
Scientists make old blood stem cells young again in major anti-aging breakthrough
As blood stem cells age, their lysosomes become overactive and damaged, triggering inflammation and weakening the body’s ability to regenerate healthy blood and immune cells. By calming this cellular “overdrive,” researchers restored the stem cells’ youthful function, dramatically boosting their ability to regenerate and produce balanced blood cells.
Scientists discover hidden switch in immune cells that helps the body kill deadly fungus
Scientists at the University of East Anglia (UK) have contributed to discovering a "control switch" inside our immune cells that helps the body destroy dangerous fungal infections. Researchers found that ...
MARY BRUNKOW
A chance discovery made around 80 years ago paved the way for Mary Brunkow’s painstaking work, which contributed to redefining how the immune system functions. From investigating an obscure gene dismissed as ‘junk’ by other scientists, to choosing to opt out of academia and conduct her research at a biotech startup, Brunkow has embraced the unexpected throughout her career.
The Heart Rarely Gets Cancer. Scientists Think They Know Why.
The heart's constant motion makes it largely immune to cancer. The discovery could help protect other organs.
Woman in cancer remission without treatment in highly unusual case
A biopsy of a woman's cancer seems to have triggered an immune response against the tumour, putting her into remission
How Ochsner continues to prioritize physician well-being
At the Gulf Coast-based health system, Gold-level recognition helps drive culture change, strengthen recruitment and support physician retention.
Why letting kids get dirty this spring might be one of the best things for their health
Experts say playing in dirt, mud, and the outdoors isn’t just fun for kids. It helps build creativity, reduce stress, and even strengthen their immune systems. Hear what a Boston Children’s Hospital psychologist says about why “getting dirty” matters, and how to make it part of your routine.
The body’s most mysterious organ may play a key role in longevity and cancer
A raft of research is recasting the thymus from a bit player to a potent regulator of aging and immune health.
Not Even Japanese Bathhouses Are Immune From Shocks of Iran War
High fuel costs are imperiling the Japanese sento, a long-declining industry that remains a vital social lifeline for the country’s isolated elderly.
Scientists restore memory by blocking a single Alzheimer’s protein
Researchers have identified a new potential weapon against Alzheimer’s: blocking a protein called PTP1B. In mice, this approach boosted memory and helped brain immune cells clear harmful plaque buildup. Since PTP1B is also linked to diabetes and obesity—both risk factors for Alzheimer’s—it could offer a broader treatment strategy.
Press dinner shooting conspiracy theories spread in era of fractured politics
Neither political party is immune to conspiracies in a time of intense distrust in government and media, experts say
Stressed out teen? Sleep and sports may be the cure
It seems like everyone is a little stressed out these days — and not even children in their “carefree” teen years are immune.In fact, the changes that adolescents go through during that time of their life make them particularly susceptible to stress.
Diamondbacks 4, Friars 6: Problemos en el Bullpen
Even pitching out of the ‘pen, Brandon Pfaadt isn’t immune to his old nemesis OBI….
Harvard scientists link gut bacteria to depression through hidden inflammation trigger
A gut bacterium may be quietly fueling depression through an unexpected chemical twist. Researchers found that when Morganella morganii interacts with a common pollutant, it produces a molecule that triggers inflammation—something strongly linked to depression. This finding helps explain how gut microbes can influence brain health at a molecular level. It also raises the possibility of new treatments that target the immune system rather than just the brain.
Marshall Health Network enrolling patients in lung cancer clinical trial evaluating personalized immunotherapy approach
lungllulungHUNTINGTON, W.Va. – The Edwards Cancer Institute at Marshall Health Network (MHN) is enrolling eligible patients in a clinical trial evaluating whether a personalized immunotherapy approach can enhance the effectiveness of treatment following lung cancer surgery. The study is investigating the use of an individualized therapy designed with a tumor’s unique biology from a surgical sample to help the immune system better […]
Carrie Ann Inaba shares her struggle to manage hidden, invisible illness: 'It's real'
Carrie Ann Inaba shares her silent struggle with Sjogren's disease, an autoimmune condition that she says went undiagnosed for more than 10 years.
For the first time, scientists pinpoint the brain cells behind depression
Scientists have identified two specific types of brain cells that behave differently in people with depression, offering a clearer picture of what is happening inside the brain. By analyzing donated brain tissue with advanced genetic tools, the researchers found changes in neurons linked to mood and stress, as well as in immune-related microglia cells. These differences point to disruptions in key brain systems and reinforce that depression is rooted in biology, not just emotions.
Medical school launches first data science-focused center on immunology
The new center is the first in the Jeffrey Modell Foundation's international network focused specifically on informatics and data science. Its designation signals a shift in how researchers approach immunology, using large-scale data to better understand immune disorders and improve patient care.
The Death of Public Health
During the recent measles outbreak, the largest in more than 30 years, Robert F. Kennedy Jr. refused to clearly recommend the measles vaccine, saying instead that it was a “personal decision,” and that parents should “do their own research.” Similarly, during her recent confirmation hearing for United States Surgeon General, Casey Means was questioned by Senator William Cassidy (R, La). “You’re the nation’s doctor,” said Cassidy. “Would you encourage [a mother] to have her child vaccinated!” “I’m not an individual’s doctor,” Means said. “And every individual needs to talk to their doctor before putting a medication in their body.” In June 2025, Marty Makary, Commissioner of the Food and Drug Administration (FDA), said that COVID vaccines for pregnant women should be a “personal choice”, even though every other country in the world recommended the COVID vaccine during pregnancy due to a higher risk for severe disease. It doesn’t end there. On January 5, 2026, RFK Jr. reduced the number of routinely recommended vaccines from 18 to 10. For vaccines that protected against influenza, COVID, and rotavirus, parents were urged to speak with their doctors—to make an individual choice. (On March 16, 2026, in a ruling by a federal court in Boston, RFK Jr.’s revised schedule was invalidated.) What’s happening? Why are public health officials moving away from making recommendations for the public? The origin of this change might be rooted in the first two years of the COVID pandemic. In 2020, during the first year on the pandemic, we didn’t have anything to stop a virus that was killing hundreds of people a day and could be spread asymptomatically. We didn’t have antivirals until October, monoclonal antibodies until November, and vaccines until December. All we could do was restrict travel, close businesses, shutter schools, and mask, isolate, quarantine, test, and social distance. During the second year of the pandemic, when we had vaccines to prevent COVID, people couldn’t go anywhere without their vaccine cards. They couldn’t go to their favorite bar or restaurant or sporting event or place of worship without proof of vaccination. Some people were fired from their jobs for refusing to get vaccinated. For many, this was seen as massive government overreach and energized what has been called the “medical freedom movement.” Indeed, a headline in the New York Times declared, “How Health Freedom Became a Winning Rally Cry.” As expressed in the comments of RFK Jr., Casey Means, and Marty Makary, the medical freedom movement focuses on the individual not the community—the opposite of public health. In an article titled “Ethics and Social Value Judgments in Public Health,” ethicists from Yale University distinguished public health from medical freedom. “Public health policies,” they wrote, “are population oriented. Because individual health affects the health of others, public health measures regulate individual behavior to achieve population health goals. All raise questions about how individual autonomy and freedom should be balanced against public health interests…which respects individuals’ sovereignty over their bodies and actions as long as their actions do not harm others.” The medical freedom movement fails to recognize that it often limits the freedom of others. For example, a parent who is afraid to send a child to school where many of the students are unvaccinated. Or immune compromised children who depend on those around them to for protection. The question then becomes “Freedom for whom?” Is it your right, in the name of medical freedom, to catch and transmit a potentially fatal infection—and in so doing, take away the freedom of others? In Four Essays on Liberty, Isaiah Berlin sums it up best. “Liberty for the wolves,” he wrote, “is death to the lambs.” Thanks for reading Beyond the Noise! Subscribe for free to receive new posts and support my work. Subscribe
Are you a woman who makes life easier for everyone else? Beware – you could endanger your health
A new claim is doing the rounds online: that women who are too nice risk getting an autoimmune disease. And while aspects of this message are clearly dubious, there’s a reason it is resonating, writes Emma Beddington
Tribune Editorial: Utah officials need to raise the alarm about measles
It’s a disease that can cause misery, hospitalization, birth defects, swelling of the brain, deafness, a weakening of the immune system that can last for years and, on rare occasions, death.
Experimental drug doubles one-year survival in pancreatic cancer
A new drug that works by making tumors more susceptible to chemotherapy and the immune system has increased survival in those with advanced pancreatic cancer in a trial.
Scientists remove “zombie” cells and reverse liver damage in mice
A rogue set of “zombie” immune cells may be driving aging and fatty liver disease by flooding tissues with inflammation. Researchers found these cells accumulate with age and high cholesterol—and can make up most of the liver’s immune cells in older mice. When scientists removed them, liver damage was dramatically reversed, even without diet changes.
95% of people carry this virus and scientists may have just found how to stop it
Scientists have taken a major step toward stopping Epstein-Barr virus (EBV), an extremely common infection linked to cancer and chronic disease. By using mice engineered with human antibody genes, researchers created powerful human-like antibodies that block the virus from attaching to and entering immune cells. One of these antibodies completely prevented infection in lab models with human immune systems, marking a breakthrough after years of difficulty tackling EBV’s ability to invade nearly all B cells.
'It's incredible, like science fiction': How a new wave of immunotherapy is eliminating cancers
After nearly 100 years of development, treatments that bolster the body's immune system to fight cancer are coming of age – and saving patient's lives.
How aggressive breast cancer turns off the immune system
Researchers are launching a new project to crack the mystery of aggressive breast cancer, where predicting disease progression remains a major hurdle. By studying how tumors interact with and suppress the immune system, scientists aim to identify new biomarkers that reveal how the cancer evolves. Using real patient samples, the team hopes to turn earlier discoveries into practical clinical tools. The goal: more precise, personalized treatments that can outsmart even the most dangerous tumors.
Hidden weak spots in HIV and Ebola revealed with breakthrough nanodisc technology
A new nanodisc-based platform lets scientists study viral proteins in a form that closely mimics real viruses, revealing how antibodies truly recognize them. This approach uncovered hidden interactions in viruses like HIV and Ebola that traditional methods missed. By recreating the virus’s membrane environment, researchers can better understand how immune defenses work. The technique could speed up the development of more effective vaccines.
Your nose could detect Alzheimer’s years before symptoms begin
Losing your sense of smell might signal Alzheimer’s far earlier than expected. Scientists found that immune cells in the brain actively destroy smell-related nerve fibers after detecting abnormal signals on their surfaces. This damage begins in early stages of the disease, well before cognitive decline. The discovery could help identify at-risk patients sooner and improve treatment timing.
Science of seismic proportions
Arizona’s deserts might not be situated on a tectonic plate boundary where geographical activity can cause earthquakes, but that doesn’t make the state immune from the disturbance of tremors.It has been 139 years since Arizona’s strongest recorded earthquake on the Pitaycachi fault struck in 1887. The 7.5 magnitude event, known as the Sonoran Earthquake, took place near the southeastern Arizona-Mexico border.
Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset'
She no longer needs her daily blood transfusions.
Scientists discover spice synergy that boosts anti-inflammation 100x
Chronic inflammation often works quietly in the background but can fuel serious diseases like diabetes, heart disease, and cancer. New research reveals that everyday plant compounds—like menthol from mint, cineole from eucalyptus, and capsaicin from chili peppers—can team up inside immune cells to dramatically boost their anti-inflammatory power. While individual compounds showed modest effects, certain combinations amplified results hundreds of times over by activating different cellular pathways at once.
Scientists discover hidden gut trigger behind ALS and dementia
A new study reveals that gut bacteria may play a key role in triggering ALS and frontotemporal dementia. Harmful sugars produced by these microbes can spark immune responses that damage the brain. This breakthrough explains why some genetically at-risk people develop the diseases while others don’t. Even more promising, reducing these sugars improved brain health in experiments, hinting at new treatment possibilities.
Scientists discover spice synergy that boosts anti-inflammation 100x
Chronic inflammation often works quietly in the background but can fuel serious diseases like diabetes, heart disease, and cancer. New research reveals that everyday plant compounds—like menthol from mint, cineole from eucalyptus, and capsaicin from chili peppers—can team up inside immune cells to dramatically boost their anti-inflammatory power. While individual compounds showed modest effects, certain combinations amplified results hundreds of times over by activating different cellular pathways at once.
Never had the flu? Scientists may know why
Scientists estimate somewhere between 5%-35% of people do not get sick from the flu despite being exposed to the virus that causes it. Now, researchers may have figured out why. The team looked at mouthwash samples from 19 healthcare workers who, despite frequent contact with infected patients, report never getting flu symptoms. Today on Short Wave, we talk about how what they found could help scientists develop treatments and strategies to protect people who do get the flu. If you liked this episode, check out our show on an effort to map the entire immune system.Interested in more health science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Scientists Discover Why Flu and COVID Hit Older Adults So Hard
A new study reveals that aging lungs may play a major role in why flu and COVID can become so dangerous for older adults. Researchers found that certain lung cells can trigger an exaggerated immune response, creating clusters of inflammatory cells that end up damaging lung tissue instead of protecting it. In experiments, activating this aging-related signal in young mice caused their lungs to behave like older ones, leading to severe illness.
Scientists cured type 1 diabetes in mice by creating a blended immune system
By creating a hybrid immune system between the recipient and the donor, researchers were able to transplant insulin-producing cells that were not rejected.
Trump isn't immune from civil claims that his Jan. 6 rally speech incited riot, judge rules
U.S. District Judge Amit Mehta's decision now sets the stage for a possible civil trial.
Scientists are working on “everything vaccines”
Scientists are developing broad-spectrum vaccines that could protect against multiple virus families by targeting more conserved areas of pathogens and also better-training the body’s innate immune system.
Understanding protein motion could greatly aid new drug design
For many of us, “protein” is the key element of a food order. However, beyond your preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is encoded in our genes. Proteins have critical functions in living cells: They help repair and build body tissues, drive metabolic reactions, maintain pH and fluid balance, and keep our immune systems strong.
Scientists find gut bacteria inject proteins that control your immune system
Gut bacteria aren’t just passive passengers—they can actively send proteins straight into our cells. Using microscopic injection systems, even harmless microbes can influence immune responses and metabolic pathways. Researchers found these interactions may play a role in inflammatory diseases like Crohn’s. It’s a major shift in how scientists understand the microbiome’s power over human health.
“Night and day”: Adventuring through childhood with newfound immune systems
This article discusses the significant impact of an accelerated FDA-approved gene therapy on children with severe leukocyte adhesion deficiency-I. Families share how their lives have transformed from chronic hospital visits to thriving, healthy lifestyles following the treatment at UCLA.
Michigan measles outbreak: Confirmed cases grow to seven, including child under 5
The Washtenaw County outbreak has seven confirmed cases and one hospitalization. Officials are asking that anyone unvaccinated or not already immune to measles stay away from others for a full 21 days after exposure.