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How governments worldwide are shaping what AI can say about politics
With the U.S. midterms approaching, about one in five voters has asked AI chatbots about elections and politics, a recent survey found.
Robbery turns deadly at Fairfield business
A man was found dead inside the business, according to police
Robbery turns deadly at Fairfield business
A man was found dead inside the business, police said.
Police: Robbery, homicide investigation underway at business along Dixie Highway
Officers are investigating after a man was found dead inside a business along Dixie Highway, according to Fairfield police.
Scientists Find 46,000-Year-Old Bone Fragments in a Cave, Leading to Groundbreaking Discovery
Six ancient bone fragments found in a Spanish cave belonged to a male Neanderthal, and their well-preserved DNA could reveal new details about his life
From ‘50 bucks and a 423 credit score’: Family popcorn business marks 8 years
The founder of Robinson’s Popcorn, a family-run West Michigan business, is celebrating eight years in business by passing the keys to his daughter.
GTA 6 Platform Poll: 36% of DF Viewers to Play on PS5 Pro after 30,000 Votes
With only one in five planning to play on Xbox - and thousands of comments in favour of PC.
Samsung Has Already Found the Next Way to Unfold a Phone
A leaker claims that the long-awaited Galaxy Z Slide is finally upon us.
John M. Williams on hunting rights, wolves and the urban-rural divide
Colorado hunter, angler and founder of Colorado Wolf Tracker, John M. Williams, joins The OpEdge to discuss Amendment 83, wolf reintroduction and the growing divide between urban and rural Colorado. Williams tells host and deputy opinion editor Antonio Olivero why he believes protecting hunting and fishing rights is essential to wildlife conservation, what he sees […]
WHS Students Create Women in Science and Engineering Club
Two students have founded the Women in Science and Engineering (WISE) Club at Westfield High School.
Sundar Pichai: Google’s Frontier Imperative, Compute Scarcity Dilemmas, Future AI Products and Businesses
Alphabet CEO Sundar Pichai has little patience for doubts about Google’s willingness or capacity to compete at the frontier of AI. His company’s latest Gemini 4 Argon model — long-promised and recently delivered — beats OpenAI and Anthropic’s latest public models on coding, math, science, and knowledge-work benchmarks and has placed Google’s AI back among the world’s best. Amid chatter that Google was fine with good-enough lightweight ‘Flash’ models, Pichai pushed back hard against any suggestion that company is limiting its research ambitions. “We won’t do it any other way,” he told me in a Big Technology Podcast interview recorded this week at Google’s Mountain View headquarters. Pursuing cutting-edge research is costly for Google, requiring compute and chips that otherwise could be sold at a high markup by its cloud business. But Pichai said allocating resources to frontier AI development is “ground zero” for Google. “Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development,” Pichai told me. In our conversation, we discussed Argon (which Pichai says processed three times as many tokens as Gemini 3 in the 72 hours after launch), AI’s role in developing better models, the AI interface of the future, competition with OpenAI, Google’s partnerships with Anthropic and Apple, data centers in space, and the nature of his optimism. You can read the full conversation, lightly edited for length and clarity, below, or listen to it on Apple Podcasts, Spotify, YouTube, or your podcast app of choice. Alex Kantrowitz: Google is back at the frontier with Gemini 4 Argon, which beats OpenAI’s and Anthropic’s public models on benchmarks spanning coding, math, science, and knowledge work. The conventional wisdom was that Google had given up on the frontier to focus on fast, good-enough models for its products. That was wrong? Sundar Pichai: Very wrong. Look, we are so committed to being at the frontier. It’s in our DNA. We won’t do it any other way. We’ve been thinking about the AI frontier for well over a decade now. The frontier is very dynamic. It’s very competitive. It’s very exciting. I couldn’t be more pleased with how Argon has come together. We took our time with it. We made sure we tested it safely and deployed it carefully. We took a bit longer than our other models, given its capabilities. Across the board, be it for agentic work, knowledge work, coding, creative tasks, Argon is one of the really good frontier models. The first 72 hours since we launched, it’s almost up to 25 trillion tokens used, which is about three times what Gemini 3.0 had in the first 72 hours. And we are capacity constrained as we are serving it. Excited, but there are always areas….. You know, the frontier is very dynamic, and you have to keep evolving the models. There are areas which we can see we need to improve as well. We’ll be at work on all of that as well. Which areas? On any given model, Argon would be across the board better at everything if you just look even two months back. But the space is so evolving. Even on coding, for example, there are pockets where we know we need to do better, and there’s clear feedback. We’ll make it better. The argument for standard models is that they’re already good enough to build great products, with the frontier valuable only for certain tasks. Meta built Muse with good models rather than the best, and Google could put standard models into Maps, Gmail, and Search. Why isn’t that sufficient? It’s definitely not how I have thought about it at all. We are deeply committed to driving the state of the art and actually pushing where this technology can go, all the way from transformers. That’s a journey we’ve been on. You will see us continue to do that. When you’re at the frontier, you get an earlier look into the emerging capabilities, earlier than others, which helps you better prepare for the future. We are fortunate to have a wide set of opportunities across consumer and enterprise. Some of our cloud customers, for sure, want the model at the frontier. The frontier models will be better at developing the next set of models in an era of recursive self-improvement. I would argue it matters there. Internally, we have definitely seen a steep point of inflection by deploying Argon to our developers. It definitely tackles problems which our previous models could not do. Being at the frontier puts you at the innovation frontier and helps you drive that as well. There is room for models of all sizes and capabilities. That’s why we did Flash, Flash-Lite, etc. I agree with you that you can develop very good product experiences with not necessarily the most frontier model, because they tend to be slower and more expensive too. But we care about the Pareto frontier, and we’re committed to doing all of that. You said developing frontier models gives you a look at what’s coming. What do you see on the horizon? What makes this moment so exciting is you build something which you think is a culmination of months of work, and you put it out. You already see clear headroom ahead. We’ve all been working on these agentic, long-horizon capabilities, but clearly the frontier is going to have multiple of these agents working together to do things. That’s an example of an exciting paradigm underway. It’s also clear to me that users, both in consumer and enterprise, will have access to some multi-agent framework for them, working all the time doing things. It feels like a moment of infinite possibilities. Sergey Brin said one of Argon’s core innovations was relying more on the model to help develop the model. Yet incidents involving OpenAI’s bots breaking containment and Google’s bots accessing a site they shouldn’t have suggest these systems still aren’t perfectly aligned. Isn’t there reasonable cause for concern about accelerating toward recursive self-improvement? There are three parts to your question. Let’s first talk about RSI itself. You’re right, Sergey mentioned RSI being a critical contributor as we are developing Argon. But to be very clear, today, in a continuum, we are pretty far from the end state of RSI or something like that. The right way to describe it is you have RSI loops along with AI researchers in various aspects of model development. You almost have agents helping AI researchers in some automated way work together to build these models. It’s good to at least understand where we are today, and it’s super exciting. I expect that continuum to keep making progress as we go into next year. The second question is around safety. Security comes from defense in depth. You’re talking about alignment, obviously. We all are doing a lot of work to make sure the models are as aligned as possible. But it’s an active area of research, and there are clear gaps. That’s not the only thing we rely on. You have the work you do on alignment, but beyond that, we put a lot of effort into real-time monitoring as these models are working. Making sure you have good telemetry into what’s happening so that you can intervene in real time if you see unexpected behaviors. How you do that, the architecture with which you do that, how you make sure it’s all sandboxed and isolated in a way that it can continue doing its job during real-time monitoring — these are all areas of investment. Obviously, when we deploy these models, giving customers, enterprises, control, both with real-time monitoring, but their ability to decide where they deploy, what type of data which models ever have access to, etc. All that work is very, very important, and we are doing a lot of that. As an industry, we need to constantly up our game and take the time to do all this stuff, including dedicating the compute required to make sure you can safely deploy these models. The third part is: Is it all enough? This is why there are a lot of conversations in the industry, and I think it’s reasonable to be worried. The right way to approach something you worry about is early on thinking about what more we can do. As an industry, you’re definitely seeing increased levels of work on alignment, testing for safety, etc., as we deploy these models. The next step would be developing better standards so there are cross-industry standards of how we do these things, including the ability to evaluate using independent evaluators. If you look at areas like financial controls, we have accounting standards, we have independent auditors. Those are all the next natural steps for us as an industry to work toward, and regulation will end up playing a role as we go through all of that as well. Google pursues both language models and world models, while some other AI companies like OpenAI have focused more heavily on LLMs as the path to AGI. Why is world-model research important to you? As humans, you obviously perceive the world around you, and you’re taking all those inputs. Making sure these models are able to understand the laws of physics, simulate the world in high fidelity. All that, I think, are key enabling blocks for intelligence. We are working across all possible applications of this. Take an area like robotics. It’s not an accident: If you look at embodied reasoning benchmarks, Argon is state of the art. That all comes from our experience building world models. Inherently, I would expect there will be architectures which will converge all of this in the future. But for us, we view this as, today, this jagged frontier that is intelligence. We want to be at the frontier of all the possible approaches, and that will help us both drive better research, better insights, and develop a much better AGI model, is how we think about it. Some people argue Google should focus on selling its computing resources rather than using them for AI research. Cloud wants to sell compute at a high markup, while researchers need a very big computer to build the best models. How do you balance those demands? Ground zero for us is making sure we are investing in the compute that’s needed to be at the AI frontier. In 2015, I set the company to be AI-first. AI is that key horizontal ingredient across everything we do, all the way from Search to Cloud to Waymo. That is ground zero for us, making sure both for research and developing the models that we have enough compute needed. Beyond that, we have these independent businesses which each have their own long-range plans. They’re using those long-range plans to project forward, and we plan for compute for all of them. The cloud team, they have a business and they have a projection and they have demand signals. They have committed contracts. With that help, we can plan on a long-term compute trajectory for them. We’re fortunate to have this wide set of opportunities. There’s no company in the world which isn’t making trade-offs at any given moment in time. But the first principles we operate on is making sure we have enough compute to invest in the frontier, and that’s non-negotiable, and everything else works on top. Remember, we are building our own compute, our own data centers. There are long lead times. The compute we have today is a function of decisions I made in 2024. Even if you think back to a year from today, last year the agentic coding takeoff hadn’t happened. Today, obviously, when you sit and look at anything, everyone is short—not just us, other companies—and everyone wishes you had two times what you had planned for. That comes with the territory. At any given moment in time, we are planning for what we would need two to three years out in the future. You’re going to find some decisions you make may look suboptimal two years out, depending on where the state of the art is. I don’t spend too much time thinking about it. The way I think about compute allocation is making sure Google DeepMind, both for research and frontier model development, is cutting edge in terms of compute access. After that, we plan for all our businesses. It’s great we can provide our compute to other people too, like we have done. It allows us to scale that up, get real tests for it in the widest application set possible, test it in the real world, and make sure we are at the cutting edge of technology at every layer of our AI stack as well. Ben Horowitz relayed on a podcast that Andy Jassy had said compute was sold out until 2028. Are you seeing the same thing? If today a customer is coming out and asking us for compute in ’27, that is incredibly difficult to do. Even last year we went out and leased some short-term compute to accommodate some customers and help them out. But yes, we are all dealing with similar timelines. Every major technology shift seems to involve overbuilding, from railroads to fiber. Do you think that’s happening here? It depends on the time frames you’re looking at. This level of build, if I take a long enough time frame, it makes complete sense to me. We are at early stages of the most consequential technology ever, and this is not like fiber. It’s not dark. We are using it. We are capacity constrained on a daily basis. The applications, the underlying technology is improving rapidly. But running a company, the way I work through the moment is you look at your demand signals. You look at your committed revenue opportunities that you’re getting in the form of contracts. You balance that with the underlying technical capability, or internally you balance how we are using it internally, the model trajectories. Based on all that, you take a disciplined approach—a confident, aggressive, but disciplined approach—to plan out compute. But when you talk about the broader economy as a whole, you’re having people operate with various levels of risk. I focus on what I can control as a company and plan through it. If your question is, can there be an overbuild? Yes, because you can have some constrained components. Remember, what matters is a set of everything you need to build out that compute. Memory, electricity, electricians…. Land. Like 2,000 components or more. You could get constrained at some point. There could be things which cause bottlenecks, and then you could have overbuilds. There could be external shocks to the economy. There are macro risks. All that is possible at any given time. But am I confident that the compute we are planning for, we will have uses for it given enough time? Absolutely, yes. I was in the room when you said AI would be as profound as fire and electricity. If you believe that, shouldn’t you give researchers the biggest possible computer, even at the expense of today’s cloud profits? We’re all doing some form of that. Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development. What you’re seeing is true already. But you want to be thoughtful. Even our AI researchers have some constraints, which are also good. That’s what inspires creativity. That’s what helps you come up with a more efficient algorithmic breakthrough, maybe to use less memory. What we are committed to is to invest what’s needed to stay at the frontier. OpenAI President Greg Brockman told me a few months ago that the ideal AI product might have no interface at all—just as natural as conversation. What do you think the interface looks like in the age of AI? Computing historically has been humans adapting to computing. With AI, it’ll be the other way around. The technology will adapt seamlessly to how humans live and go about their day-to-day life. You want to be able to speak to that AI when you want to. It has context. It can be persistently running somewhere, give you continuity. You’re not dealing with a lot of complexity. It’s natural. All that makes sense to me. That doesn’t mean it won’t have any interface, however. Nowadays, even on my phone, Gemini voice models are so good. I can just press the microphone button. I can just ramble. That’s why we call it Rambler. I can ramble. It intelligently corrects with my personal context. Even my friends’ names, weird names, it gets it right, even if it first guesses it wrong. It’s amazing. I’m not going in, backspacing, editing once I finish saying it. It’s remarkable how good it’s gotten. But there are going to be moments you will need an interface. You may want to entertain yourself. You may want to watch a video. You may ask your AI to create something, and you want to watch it, consume it. The way I think about it is, you want it to be as seamless and as natural as possible, and that you are not doing the hard work adapting to whatever the interface is. The technology is adapting to how you’re working at any given moment in time. When I asked Sam Altman about competition from Google, he argued that OpenAI was building AI-native products and implied Google was bolting AI onto existing ones. Do you accept that framing, and can a “bolt-on” compete with an AI-native product? First of all, it’s a very dynamic moment. We are all pushing each other. OpenAI has pushed us as a company too. This is not just we are doing something to them. Far from it. Yes, Google went into its own version of a code red too. In the AI moment, all of us have to respond with varying levels of urgency at any given moment in time. We are constantly building new products as well. Gemini was built from the ground up as a product—the Gemini app I’m talking about. Or tomorrow, as all of us are adapting to agents, are you bolting agents onto ChatGPT, or are they building it natively? How would you think about that? You can always put these questions back. I don’t think of it that way. I think of it as you want to build world-class product experiences that are AI-native and they are winning. Some of it is adapting products, some of it is rethinking new experiences. They will all be part of how you approach this moment. How do you expect to make money from these AI interfaces? If an agent recommends a product and I buy it, should it take a cut of the sale, even if that’s disclosed? I’m going to put enterprise aside. Consumers are going to increasingly value this technology. Take software developers today. Developers are willing to pay for these coding models because it really helps make them more productive. Nobody would want to code the way they were coding three years ago, or even the same time last year. When you’re delivering value, there’s value to be had. I’ve never seen examples where consumer products really scale to billions of users, where people are using it intensely, and haven’t had monetization to go along with it. If you’re providing value to people, there is inherent value to be had. The nature of it may change. You’re asking a scenario in which agents are doing stuff for you. At the end of the day, you will have commercial needs. The agents need to fulfill those commercial needs. The providers on the other side are going to see value in that. There’s going to be some mechanism by which it gets fleshed out. That’s what an efficient system does. But what matters is that you’re building those world-class consumer experiences. I promised myself one product feature request: Can you make Gemini-powered search in Gmail as good as searching Gmail through ChatGPT? What’s going on here? One of the exciting things we announced recently is the unified Gemini agent for enterprise, and we’re bringing that to consumers. These are persistent agents which run 24/7 in the cloud. We’re spinning up a micro VM effectively for every query, and from the runtime, the harness, the model—it’s all a headless service. It’ll work everywhere, and it has your context with you. You can address this agent whether you’re in Workspace, in Search, in Gemini. Agents are going to drive this unification from a customer experience, which people are looking for. When you have a broad product portfolio and you’re moving forward fast, there are always areas where you’re moving forward faster than some other areas. That’s valid feedback. But we are putting a lot of time and effort into making sure, as we build out our agentic experience, that unification and that capability works well across all these services. People have asked where Google’s equivalent of Muse or Dots is. Do you anticipate creating a new product to compete with them? Our goal with Gemini is to be a personal, proactive, and powerful assistant. That’s what we are working toward. You saw us describe the early versions of it at Google I/O this year with Spark. Effectively, already, if you open the Gemini app as a Pro or an Ultra user, you see Chat and Task, and they start giving you that agentic experience. With Argon now, that capability is dramatically accelerated. What we announced recently in our enterprise event, we are bringing that to consumers as well. Soon in Gemini, you will be able to ask something, and it’s a continuum. You don’t need to think about whether you’re asking a chat or an agentic task. It’ll just automatically do the right thing, and it can work persistently in the background securely and get things done for you. Already, empirically, when I look at what’s coming into Gemini in our app, last year you would have tagged them and most of them would have been chats. But a steadily growing percentage is already agentic tasks in Gemini. Yes, we are going to bring personal agents to our consumers. It’ll work in the Gemini app. It’ll work in Google Search. It’ll work in Gmail. You can address it, call it, etc. We want to make sure we’re getting it right. It’ll be powered by Argon, and we are very excited to bring it to our users. Google has invested and committed tens of billions of dollars to Anthropic. What do you see in Dario Amodei that makes you want such a deep investment and partnership? Very early on, when we looked at the founding team of Anthropic, it was very clear to us this was a world-class team which was involved in some of the earliest GPT models. We were quickly able to assess that they would be at the frontier. We’ve always tried to identify and partner with companies which would be at the cutting edge of technology. We’ve done that with SpaceX. We’ve done that with Anthropic. That’s what we saw, and we had a chance to partner. Is your partnership with Apple to license Gemini for Siri expanding, contracting, or standing still? For both us and Apple, that partnership was about translating the capabilities of AI into better experiences for users. I thought Apple has done a phenomenal job of incorporating—they customize these models and build it into Siri—and it’s been great to see the reception. We are committed to doing more. You’re going to do more with them? There’s nothing specific to comment, but it’s a partnership. It’s working well. What have you learned so far about the feasibility of data centers in space? It’s a very exciting project. Projects like this remind me—I still recall that moment in the desert for the DARPA Grand Challenge, watching the Stanley car compete in it, which ended up being the basis for Waymo. With all these technologies, you’re at a moment in time where it looks a bit like sci-fi, but 10 to 20 years down the line, it’s actually working in a meaningful way. I feel the same in space. We’ve always believed in betting big on these technologies. Quantum has been a great example of it. We’re probably 10 years into the journey. Waymo, we are almost 20 years into the journey. Space, we are two to three years into the journey. It’s clear to me that it’s an approach which will make a lot of sense in the future. Being in sub-synchronous orbits with 24/7 access to the most abundant form of energy we have access to will make a lot of sense for this exponential increase in compute that we are going to need. Having said that, this is a challenging project. The team has disciplined milestones. It was a super exciting milestone to send the TPUs up to space. Sometime, as we are speaking, we are expecting a “hello world” moment from them. I look forward to seeing that happen, and we’ll continue investing here too. You previously said 25% of the code written within Google was written by AI. What’s the number today? That number in our world today is meaningless in the sense that every part of what we now touch is influenced by AI deeply. What we are tracking with Argon, for example, it’s been a point of inflection. People are using Argon to really go tackle complex projects, including projects which affect millions of lines of code. In the four weeks since we have launched Argon, we have seen a 30% increase in CLs, and more importantly, almost a similar increase—a one-third decrease in rollbacks. People are writing code more productively and better code with it. We are tracking it with newer metrics now. How are you dealing with opposition to data centers? If you can’t build in the U.S. the way you want to, where else do you go? We’re very committed to building our data centers very responsibly. When I look at our largest data centers in some of the communities where we have been the longest, I visit them, I talk to people. There are people who come and tell us their kids have gone to college because of our investments in these communities, and we’ve grown in those communities. To me, this is about doing it right. Engaging with the communities early, doing it transparently. We are committed to making sure we are bringing incremental power, and we cover 100% of the cost of our power needs for these projects. It’s understanding the impact on neighborhoods and making sure you’re working thoroughly to address them. Done rightly, you can continue making progress. But we are constantly taking feedback into account. I do worry not everyone operates the same way. People have been surprised by data centers showing up in their backyard. Those are all important. As an industry, we should continue to do better. But part of the reason, in a 20-year time frame, we are thinking about things like data centers in space is making sure we are able to put these data centers where maybe the trade-offs will be different. What unproven area of AI is Google working hardest to crack? Is it continual learning—getting models to keep updating after release—or something else? There are multiple parallel paths. You saw with Argon we have a million output tokens. With our Gemini models early on, we had a one-million context window on the input side. These are all examples of breakthroughs we are constantly working on. How do you think about synthetic data? How do you think about continual learning? How do you think about more efficient architectures? We do dedicate a meaningful percentage of our compute to these research bets too. It always goes hand in hand, including our world models. Those are all bets we are placing. Sometimes, as part of these bets, there are ideas that emerge which just make their way into the mainline models. Maybe we don’t fully talk about it, but we have multiple steps in these areas. Working in technology requires optimism that building something will improve the world, but those bets can leave real consequences when they fail. I recently returned to a town in El Salvador where enthusiasm for Bitcoin had given way to unfinished construction and something resembling a ghost town. How do you maintain the optimism you spoke about in your Stanford commencement address while accounting for those risks? I genuinely have a deep conviction that improving technology and improving access to technology makes people’s lives better. It’s been my personal experience in my life, out of which comes that deep conviction, optimism. But with that, I’ve always felt humanity’s journey is always about working hard to harness that technology to make it work well for society. The optimism is not an optimism that you just build whatever you want, whenever. You work hard to make sure you’re building technology in the service of humanity, to make the human condition better. That’s got to be the defining goal as we are approaching it. With that framework, I’m very, very optimistic. We are in very early stages of the kind of progress that we are going to see on many areas. We’re all talking about areas like healthcare. A lot of the progress is ahead. The ability to make things in a fundamentally cheaper way on many things where things have been getting expensive for a long, long time, discovering new materials, etc., which really bend the curve—it’s tough to step today and understand the impact of all that, but they’re going to be very profound. I’m very optimistic, but we have to be rightfully concerned about all the ways this technology can go wrong. Sundar, I know you don’t do many of these. Thank you. Thanks, Alex. Appreciate it.
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Known by many names, but rarely found in such mint condition.
The Bears’ Missing Piece May Have Just Moved Within Reach
The Bears have found ways to survive a depleted defensive front. Now Ryan Poles should explore adding someone who could […]
Nearly 2-In-3 Small-Business Owners Sacrifice Their Pay As Costs Soar
The survey, conducted by Small Business for America’s Future, found that 72% of respondents believe running a business has become more difficult over the past year,
Brightstar Capital Partners Invests in Material Handling Group, a Technician-Led Provider of Material Handling Equipment and Aftermarket Services
CANTON, Mich. & NEW YORK, October 20, 2026--Brightstar Capital Partners ("Brightstar"), a private equity firm focused on partnering with founders, entrepreneurs, and management teams, has acquired a majority interest in Material Handling Group USA ("MHG" or the "Company"). Financial terms were not disclosed. MHG is a technician-led provider of new, used, and rental material handling equipment and aftermarket parts and service, serving customers across Michigan, New York, and the Mid-Atlantic reg
2026 Business & Economic Outlook to Explore Key Trends
The Northwest Indiana Business RoundTable ( NWIBRT ) and the Construction Advancement Foundation ( CAF ) will host the 2026 Business & Economic Outlook on Oct. 30, bringing business leaders, …
Gen Z founders want lean teams, but they still crave coworkers
I visited a NYC office full of Gen Z startup founders and discovered why building a company with AI doesn't always mean wanting to work alone.
'They’ve awakened him’: How a wealth tax fight made Brin a political force
After years of sporadic giving, the Google co-founder has unleashed spending that spans from the billionaire tax to housing and environmental policy.
Scientists think they've worked out why anything exists at all. Is this the answer to the oldest problem in the Universe? | BBC Sky at Night Magazine
Could scientists have finally found the particle that explains why matter triumphed over antimatter and why anything exists at all?
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
GLP-1 drugs may protect kidney health in people with bipolar disorder
Mayo Clinic researchers found that GLP-1 receptor agonists, medications widely used for diabetes and weight management, were associated with a lower risk of dialysis or kidney transplantation in adults with bipolar disorder and chronic kidney disease.
Franciscan Health Dyer adds OrderAhead food locker in partnership with Food Bank of NWI
Technology enhances partnership aimed at fighting Region food insecurity DYER, Ind. – Franciscan Health Dyer now has an OrderAhead food locker thanks to a partnership with the Food Bank of Northwest Indiana and generous donations to the Franciscan Health Foundation. The OrderAhead food locker program was designed by the Food Bank of Northwest Indiana for neighbors with chronic concerns about adequate food access. The lockers allow food-insecure individuals to place an order online for pickup at a scheduled time. “We are thankful to be able to further enhance our impactful partnership with the Food Bank with the addition of the
Scene
In this week’s scene, we find this skeletal fellow who has found a garbage can of toxic waste recently spotted in front of a Winchester home.
75% of foreign parts found in Russian anti-jamming tech from US firms
Russia's Kometa systems for Shahed drones and Iskander-M missiles were found with 28 chips and other electronics made by US firms, per GUR.
Former 49ers WR Reuniting with Aaron Rodgers and Steelers
On Monday, October 19, while the San Francisco 49ers are taking on the Washington Commanders in Monday Night Football, former wide receiver Marquez Valdes-Scantling has found a new home in the NFL, and it’s a reunion with a QB he is very familiar with, Aaron Rodgers, and the Pittsburgh Steelers, according to multiple reports. Valdes-Scantling […] The post Former 49ers WR Reuniting with Aaron Rodgers and Steelers appeared first on HEAVY.
Scientists found 2 ways to destroy 'forever chemicals,' and 'forever' may not mean forever
The video says PFAS "barely break down in nature" and can remain for decades or even centuries.
PS5 console jailbreak on latest 14.10 firmware shared before GTA 6 release date
PlayStation may have hoped it would take longer to compromise the current 14.10 firmware. However, a homebrew developer has found a way to exploit Sony's software. The PS5 console jailbreak could enable piracy of games like GTA 6 that require the update.
Advanced materials firm founded by LANL veteran moves into Nambé facility
Discovery 2 Scale is working with AI to develop new materials for national security applications and using robotics to test and manufacture them.
Could This Centuries-Old Seafood Delicacy Hold Clues to Better Brain Aging?
Sea pineapples, a type of sea squirt known as meongge in Korea and hoya in Japan, contain compounds with potential anti-aging benefits. A study found that plasmalogens extracted from these marine animals improved memory, reduced brain inflammation, and promoted black hair growth in aging mice. But could eating this seafood offer similar benefits to humans?
The Family Business Rewritten
Founded by two brothers in Philadelphia in 1916, Govberg Jewelers has evolved over 110 years into The 1916 Company, bringing Govberg, WatchBox, Radcliffe and Hyde Park under one name. Danny Govberg and John Shmerler explain how one family business became a business of families.
Fruit and sugary drinks stood out in a three-year study of teenage mental health
A three-year study of 6,537 Australian adolescents found that higher fruit consumption was associated with a lower risk of elevated depression and anxiety symptoms, while greater sugar-sweetened beverage intake was associated with increased risk. Vegetable consumption showed no significant association with either outcome, and the observational findings cannot establish cause and effect.
Advocate Illinois Masonic Medical Center cafeteria fails health inspection; 200 live roaches found in kitchen
The cafeteria at Advocate Illinois Masonic Medical Center failed a recent public health inspection, after officials found black slime and more than 200 live cockroaches in the facility.
AI facial health recognition tools help physicians assess age and survival risk to guide personalized treatment
Researchers are using AI tools to analyze simple facial photographs to determine key indicators of a person's health. Mass General Brigham researchers built FAHR-Face (Foundation Artificial Intelligence ...
Rabid skunk found near Great Plains Regional Medical Center, health officials warn
The Oklahoma State Department of Health and Bcekham County Health DepartmentOR IMMEDIATE RELEASEOct. 19, 2026Contact: Erica Rankin-Rileycommunications@health.o
Tincher Foundation gift brings record donation to Med Center Health
The Tincher Foundation donated more than $4 million to Med Center Health last month before dissolving in September, part of a gift supporting a program that provides medical and dental care to children regardless of a family's ability to pay.
Tandana Foundation to host Dogon culture event in Mancos in November
Evening will feature storytelling, music and more
Florida Republican Party wants court to block Democrats’ Hope Florida ads
A grand jury found $10 million of Medicaid settlement money had been misappropriated, funneled through Hope Florida for political purposes.
AI facial health recognition tools help physicians assess age and survival risk to guide personalized treatment
Mass General Brigham researchers trained a new AI foundation model on more than 40 million facial images, and used it to develop AI tools to estimate biological age and directly predict survival risk in patients with cancer
Build Your Future in Healthcare: Free Workshop Opens Door to Business Ownership Team Abilities Foun
On Thursday, October 22, from 10 a.m. to 2 p.m., Rachel Jelks, founder of TEAM Abilities, will host DREAM IT. DO IT., a FREE, hands-on workshop introducing participants to the business of providing residential and community-base
TSCG promotes pair to C-suite; Colliers hire chases Philadelphia business; Foundry adds World Series winner as broker
New hires, promotions and other personnel changes
Elizabeth Holmes doc ‘You Can See Everything’ has huge opening weekend
NEW YORK — Nathan Fielder and Lance Oppenheim’s film about Theranos founder Elizabeth Holmes opened to box office numbers not seen in more than 20 years for a narrative documentary.
What Does a Human Heart Need to Grow? Scientists Found the Answer in a Bioprinted Model
Heart problems that babies are born with, called congenital heart defects, often begin developing early in pregnancy. Approximately three weeks after fertilization, the human heart is still a simple, straight tube of cells and, over the course of about five weeks, this tiny structure must undergo a remarkable transformation to reshape itself into the complex organ that eventually pumps blood throughout the body.
Smart TV owners have found a new use for AI: Removing home-screen clutter
Some TV owners are asking Claude Code to clear out the junk so they can just watch their shows.
Life in the deep Gulf plummeted after Deepwater Horizon
A new study has found populations of deep-water fish species, crustaceans and squid declined significantly following the 2010 Deepwater Horizon oil spill.
PlayStation founder Ken Kutaragi says discs became "metaphor for 'owning' games", and that upset at their discontinuation is a "mentality issue"
The founder of PlayStation has weighed in on Sony's decision to end game discs, saying it isn't "economically reasonable" to continue supporting them.
Kelly Vlahakis-Hanks Keeps Science Green at ECOS
Chief Executive Kelly Vlahakis-Hanks maintains a keen focus on sustainable manufacturing at ECOS, the company her father founded 60 years ago, building upon his initial idea to create non-toxic alternatives for cleaning. Van Vlahakis, a chemist, founded the manufacturer of green cleaning products at a time when no one was paying attention to ingredients. “He […]
Six years of SQMS: asking what limits quantum systems and building the answers
The founding director provides perspective on the first six years of a DOE National Quantum Information Science Research Center — the Superconducting Quantum Materials and Systems Center, led by Fermi National Accelerator Laboratory.
Richland County Foundation funds $1.4 million in grants for health & housing needs
MANSFIELD – The Richland County Foundation Board of Trustees approved grants totaling $1,477,004.99 to non-profit organizations during its October meeting. Competitive and field of interest fund grants were approved by the board to four organizations. Community Health Access Project (CHAP) received a grant to enhance care coordination services for uninsured and underinsured residents in Richland […]
Exclusive | Unilever Agrees to Sell Welly Bandage Business to Private-Equity Firm
Forward Consumer Partners is acquiring the company known for its colorful bandages and bringing back its founder as an adviser.
Business and politics: how Italy drives the transatlantic trade in the U.S.
The 51st anniversary gala of the National Italian American Foundation (NIAF) highlighted the importance of political and economic cooperation between Italy and the United States. The event showcased the breadth of Italian economic interests in the US, including defense, energy, and consumer goods, while emphasizing the significance of business diplomacy in sustaining the relationship. The gala also featured discussions on Italy-US relations and recognized the contributions of individuals and organizations to the transatlantic partnership
Business and politics: how Italy drives the transatlantic trade in the U.S.
The 51st anniversary gala of the National Italian American Foundation (NIAF) highlighted the importance of political and economic cooperation between Italy and the United States. The event showcased the breadth of Italian economic interests in the US, including defense, energy, and consumer goods, while emphasizing the significance of business diplomacy in sustaining the relationship. The gala also featured discussions on Italy-US relations and recognized the contributions of individuals and organizations to the transatlantic partnership
RWS Global sponsors new IAAPA Foundation Entertainment Task Force Scholarship
RWS Global is proud to sponsor the new IAAPA Foundation Entertainment Task Force Scholarship, supporting the next generation of talent shaping live entertainment. The program recognizes both sides …
Trust company leaders honored for connecting donors with local giving
“These are charitable dollars that likely would never have found their way to South Dakota without someone inviting those families to give back here.”
Shop These Businesses for Down Syndrome Awareness Month
October is Down Syndrome Awareness month so TODAY’s Ally Love is spotlighting six incredible small businesses from the National Down Syndrome Society all founded by entrepreneurs who have Down syndrome, including The Jam Man Sweet Heat Jam, Two Fresh Brothers and more. See all their creations!
In memoriam: Frank M. Ahern, teaching professor emeritus of biobehavioral health
The College of Health and Human Development is saddened to share the news that Frank Ahern, teaching professor emeritus of biobehavioral health, passed away last month. Ahern came to Penn State in 1983 as a senior research associate in the Department of Health Policy and Administration and went on to co-found the Department of Biobehavioral Health in 1991.
Judicial Dialogues on Health and Climate Change: An Interview With Alicia Ely Yamin - Petrie-Flom Center
How can courts respond to the health impacts of climate change? On the occasion of a conference at Harvard Law School on 29 October 2026, sponsored by the Walter de Gruyter Foundation, we spoke with one of its conveners, Alicia Ely Yamin, about the right to health, climate change, and the role of judicial enforcement.
Carl Sagan Institute director to deliver URI Honors Colloquium lecture on Oct. 27
KINGSTON, R.I. – Oct. 19, 2026 – Over the past decade, Lisa Kaltenegger, founding director of the Cornell University Carl Sagan Institute, has worked with NASA, academic institutions and multiple countries to find new ways to spot life in the cosmos. Finding such life has significant implications when it comes to understanding outer space more […]
How Boston Dynamics is turning robots into a real business
CFO Amanda McMaster explains how Spot found paying customers and why Hyundai's backing could help Atlas scale.
Gairdner Science Week 2026 Brings World-Leading Scientists to Toronto for Free Public Lectures
/PRNewswire/ -- From October 19 to 23, the Gairdner Foundation presents Gairdner Science Week 2026, bringing together scientists, students, healthcare...
Foundation to hold trials this October
The Leeds United Foundation will be holding open trials for aspiring players on Friday 30 October, aiming to potentially recruit any promising players to the Academy system and Foundation centres.Thes...
Bluey's Happy Snaps launches with an unobtainable Xbox achievement
After launching into Xbox Game Pass last week, players have found a broken achievement in Bluey's Happy Snaps that prevents them from earning the Mythic.
New Israeli fund seeks $40 million to invest in mental health and longevity
Founded by Esther Barak Landes and Adi Ostry Matalon, Alma will back technologies spanning mental health, suicide prevention, digital therapeutics, brain health and dementia. Sheba Medical Center will serve as its strategic partner.
Chicago’s tech startups are rediscovering the office
Remote works until it doesn’t, founders say. When culture and speed outweigh convenience.
Mass. nail salon workers face low pay, health hazards
A survey of Massachusetts nail technicians found that most earn less than $40,000 and suffer from headaches, asthma, and nausea.
The Brockman Gallery is celebrated in new LACMA exhibition
The Brockman Gallery, founded by brothers Alonzo and Dale Brockman Davis after the Watts rebellion, became a community hub for multicultural experimentation in art. That legacy is explored in a new exhibition at LACMA.
America’s next big healthcare reform might already be underway
Colorado found a way to make health care cheaper. Other states are paying attention.
Opinion: Helping families requires partners to work together
Community partners, businesses, philanthropy, and government came together to make a program like Rx Kids possible, writes Yazeed Moore of the W.K. Kellogg Foundation.
Video: Griffon Bookstore co-founder looks back on 50 years in business
How the No Surprises Act’s nonprofit arbitrators are operating like 'mini gods' and getting rich doing it
A STAT investigation found that several nonprofits are raking in massive sums by acting as arbitrators in a program that helps protect patients from surprise medical bills.
Real Madrid’s 4-1 win yielded little from set pieces
Real Madrid beat Sevilla 4-1 at the Santiago Bernabéu on Sunday, October 18, but the set-piece analysis published by Managing Madrid found little threat from either side’s dead-ball situations. Kyl...
Opinion | Has Hyannis found the secret to a fun, thriving downtown?
Zoning changes plus beautification money raised from local businesses spur housing construction and attract businesses.
When scientists went into a flooded cave in Jamaica, they found a large-mouthed creature hiding in the darkness
It’s the first time the strange-looking fish has been photographed in the cave.
The sport of online harassment
Non-consensually posted intimate images can devastate women – and beget male bonding.The burner accounts on X loosely grouped into the “burnerverse” started by bonding over college sports – but soon took a darker turn when some of them began trying to make salacious rumors or non-consensual intimate images of young women and their names go viral. Ej Dickson investigated the burnerverse for Wired, profiling one of these women who were doxxed – and found links between these burner accounts and college fraternities. But what makes misogyny such a potent tool for men’s bonding? And with laws against non-consensually distributed intimate images in all 50 states – how is it still happening at scale?To talk more about the culture that supports this kind of harassment and the structures that keep it in place, Brittany is joined by Ej Dickson, senior culture writer at wired, and Dr. Mary Anne Franks, professor at the George Washington University Law School and president of the Cyber Civil Rights Initiative.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Four Tiny Snail Species New to Science Found on Limestone Karsts of Laos
Biodiversity surveys on Laos limestone karsts have revealed eight Alycaeinae micro land snail species, four of which are new to science, highlighting the urgent need to protect these overlooked ecosystems.
Minnesota finds discrimination in businesses’ rejection of tribal IDs
Minnesota investigators found probable cause of discrimination after a credit union and Minneapolis bar rejected Native customers’ tribal identification cards.
Early humans in America endured climate chaos—new research
Some 23,000 years ago, during the coldest part of the last ice age, people walked across the muddy margins of an ancient lake in what is now White Sands National Park, New Mexico.
Amanda Seyfried addresses evasive red carpet comments about Elizabeth Holmes: ‘What AM I even saying’
The actress, who portrayed Holmes in “The Dropout,” was hesitant to weigh in on Nathan Fielder’s new doc about the disgraced Theranos founder.
Memorial Health System receives $15,000 grant for Packaged Meal Program
The Food and Nutrition Services department at Memorial Health System has been awarded a $15,000 grant from the Community Foundation of Dickinson County to support the development of a new