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Results for " detail " 2,207 found 🔀 AI-powered Shuffle

Georgia Tech secures $5m Google.org commitment for AI science | ETIH EdTech News

Georgia Tech has received $2.25 million toward a $5 million Google.org commitment to expand AI research access across US institutions. ETIH’s edtech news coverage details plans for 15 research projects, shared computing tools and training for more than 300 researchers and faculty.

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Oct 13 • 7:01 PM EDT • Science • edtechinnovationhub.com
Recent Philly gun violence sparks concerns over mental health

A deadly police shooting, the murder of a Philadelphia police officer, and the suicide of a man linked to a double homicide have sparked recent concerns over mental health and gun violence in Philadelphia. NBC10’s Tim Furlong has the details and speaks with a mental health expert.

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Oct 13 • 5:44 PM EDT • Health • nbcphiladelphia.com
Player Availability Report: #NSHvSKC

Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City hits the road

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Oct 13 • 5:27 PM EDT • Sports • sportingkc.com
SOME CITY SPORTS FIELDS ARE CLOSED TODAY SEE LINK FOR DETAILS 10-13-26

****FIELDS THAT ARE CLOSED TODAY (10-13-26) ARE: AMBER MEADOWS BASEBALL, CLERESTORY BASEBALL, BOTH LOATS BASEBALL FIELDS, RIVERWALK SOFTBALL, AND STALEY BASEBALL.****What “CITY SPORTS FIELDS ARE

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Oct 13 • 1:43 PM EDT • Sports • cityoffrederickmd.gov
What the science of memory tells us about sexual assault cases

The investigation into the report of a gang rape at Cornell University has reopened a national discussion on sexual assault — in particular raising questions about how authorities respond to allegations and how well those who go to investigators remember details of their assault.

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Oct 13 • 1:20 PM EDT • Science • newswise.com
SEC announces decisions on revamped NIL policy, transfer portal

The Protect College Sports Act has passed in the Senate, but the legislation, which is aimed at eliminating some of the “chaos” that has affected college sports, and in particular, football, faces an uphill battle in the House of Representatives. Earlier this month, House Majority Leader Steve Scalise detailed some of the issues the PCSA…

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Oct 13 • 10:06 AM EDT • Sports • sports.yahoo.com
Maxx Crosby reveals what stands out when tackling Patrick Mahomes

Image Press Agency/Depositphotos Crosby shares a surprising detail about Mahomes’ reaction Maxx Crosby and Patrick Mahomes may be fierce rivals on the field, but their latest encounter has revealed a funny detail about their battles. The Las Vegas Raiders defensive end shared what he notices when he gets close enough to hit the Kansas City…

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Oct 13 • 8:30 AM EDT • Sports • sports.yahoo.com
FLIR A8481 Compact HD MWIR Science Camera

Teledyne FLIR announced the launch of the A8481, a new compact HD MWIR science camera designed for researchers and engineers who need significantly more thermal detail without changing the workflows, optics, software, and infrastructure they already use.

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Oct 13 • 8:00 AM EDT • Science • qualitymag.com
Scientists Reaffirm “Incontrovertible” Evidence of Human Influence on Climate

In response to a "deeply flawed" US government report, scientists have published an outline detailing the credibility of climate fingerprinting research and advances in the field since 2009.

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Oct 12 • 8:00 PM EDT • Science • technologynetworks.com
Scientists uncover a hidden map of the brain with 539 distinct regions

Scientists have uncovered a hidden layer of organization in the brain by creating the first detailed 3D map of its lipids, the fatty molecules essential for brain structure and communication. By analyzing millions of measurements from mouse brains, researchers identified 539 distinct chemical zones, revealing patterns and boundaries that traditional brain maps have missed. Surprisingly, even white matter, once thought to be relatively uniform, contains a complex patchwork of chemically distinct regions.

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Oct 12 • 8:00 PM EDT • Science • sciencedaily.com
Apple’s new ‘Switch to Safari’ campaign details why you should ditch Chrome

Apple is kicking off a new campaign today to promote Safari’s benefits over Chrome. With a new “Switch to Safari”...

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Oct 12 • 5:50 PM EDT • Technology • 9to5mac.com
Orlando Magic's Sean Sweeney Gets Honest After Loss to Cavs

Orlando Magic coach Sean Sweeney detailed what went wrong for his team in a 119-105 loss to the Cleveland Cavaliers on Sunday.

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Oct 12 • 2:55 PM EDT • Sports • sports.yahoo.com
‘SNL’ cut ‘Shape of Water’ sketch was makeup vet’s ‘biggest heartbreak’

‘SNL’ makeup vet Louie Zakarian detailed a ‘Shape of Water’ sketch. Pete Davidson ‘somehow broke his arm that week,’ he recalls.

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Oct 12 • 1:08 PM EDT • Entertainment • ew.com
Rep. Ilhan Omar’s home searched by federal agents in ongoing criminal probe

The Justice Department did not provide details about the nature of the investigation.

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Oct 12 • 9:42 AM EDT • Politics • nbcnews.com
High-Signal Publisher
The Law of Conservation of Information

There are a lot of details here, and the result is nontrivial though the conservation of information inequality looks utterly elementary and straightforward.

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Oct 12 • 9:33 AM EDT • Science • scienceandculture.com
NVIDIA RTX 5080 24GB reportedly launching in Q1 2027, board partners still waiting for details

: NVIDIA's rumored RTX 5080 24GB now has a Q1 2027 release window. The card would replace the 16GB model, although partners are still awaiting technical details.

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Oct 12 • 9:09 AM EDT • Technology • videocardz.com
The hostage deal that never was: Netanyahu's political calculations and the price paid

Analysis: A July 2024 hostage deal had the backing of both Israel and Hamas, but negotiations collapsed; as new details emerge, questions mount over Netanyahu's coalition maneuvering, political motives and the devastating cost to hostages and their families

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Oct 11 • 9:37 PM EDT • Politics • ynetnews.com
New Apple TV 4K, HomeView, and HomePod Mini: 16 Details Just Leaked

Just two days before Apple's "Welcome home" experience in New York, Bloomberg's Mark Gurman has leaked several details about the new products set to be unveiled, including an all-new smart home hub, a HomePod mini 2, and a new Apple TV 4K. Here is an all-in-one summary of the details shared by Gurman:Apple's home hub with a touch-enabled display will be named HomeView, seemingly confirming a trademark filing discovered by MacRumors.

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Oct 11 • 3:56 PM EDT • Technology • macrumors.com
South Texas Health System (@stxhealthsystem)

0 likes, 1 comments - stxhealthsystem on October 11, 2026: "Lead the Future of Healthcare with STHS: South Texas Health System, the Rio Grande Valley’s largest integrated healthcare network, is seeking experienced, driven healthcare professionals who are passionate about delivering quality, compassionate care to join our leadership team. Current leadership opportunities include: • Assistant Chief Nursing Officer (STHS Edinburg/Cornerstone) • System Market Director – Freestanding Emergency Department (STHS) • Director of Nursing, ICU (STHS Heart) • Director of Nursing, ER (STHS McAllen) At STHS, our leaders help shape the future of healthcare by advancing clinical excellence, enhancing operational effectiveness and empowering care teams to achieve their fullest potential. Through their commitment to safety, quality and patient-centered care, they make a lasting impact on the health and well-being of the communities we serve. If you're ready to lead with purpose, inspire excellence and make a meaningful difference, explore these opportunities and take the next step in your career with an organization that values leadership, service and innovation. For details and to apply, visit the link in our bio.".

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Oct 11 • 12:00 PM EDT • Health • instagram.com
Trump says Russia and Ukraine reach ‘energy ceasefire’ but gives no details

Trump’s brief post said only that the ceasefire takes effect immediately and that both sides had agreed to it.

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Oct 11 • 10:37 AM EDT • Politics • spectrumlocalnews.com
Trump says Russia and Ukraine reach ‘energy ceasefire’ but gives no details

Trump’s brief post said only that the ceasefire takes effect immediately and that both sides had agreed to it.

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Oct 11 • 10:37 AM EDT • Politics • spectrumlocalnews.com
😐 Neutral (-1%)
wow
100%
Scientists Say the Older Brain May Be Optimized for Something Different

New research suggests that healthy brain aging may reflect a shift in cognitive priorities rather than simple decline. The aging brain may not simply be a younger brain in decline. New research from the University of Arizona argues that healthy aging involves a shift in cognitive priorities, with less emphasis on preserving precise details and

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Oct 11 • 7:57 AM EDT • Science • scitechdaily.com
GTA 6 Official Rating Revealed

The official rating for Grand Theft Auto 6 is now available, revealing interesting details about the upcoming game.

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Oct 11 • 6:00 AM EDT • Technology • gamerant.com
Sweating the details: Sauna's potential health benefits draw scientists' interest

A group of international researchers is pushing to rigorously study the potential health benefits of sauna and other heat therapies. They hope to bring scientific legitimacy to the age-old practices.

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Oct 11 • 6:00 AM EDT • Science • npr.org
High-Signal Publisher
Sweating the details: Sauna's potential health benefits draw scientists' interest

A group of international researchers is pushing to rigorously study the potential health benefits of sauna and other heat therapies. They hope to bring scientific legitimacy to the age-old practices.

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Oct 11 • 6:00 AM EDT • Health • npr.org
High-Signal Publisher
GTA 6 Official Rating Revealed

The official rating for Grand Theft Auto 6 is now available, revealing interesting details about the upcoming game.

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Oct 10 • 8:00 PM EDT • Technology • opencritic.com
Unexpected New Details Emerge on Eagles’ Cam Jurgens Trade

The Philadelphia Eagles and Baltimore Ravens made a surprising move prior to agreeing to their Cam Jurgens trade. The post Unexpected New Details Emerge on Eagles’ Cam Jurgens Trade appeared first on HEAVY.

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Oct 10 • 2:18 PM EDT • Sports • sports.yahoo.com
😐 Neutral (17%)
ahah
50%
wow
50%
Report offers new insight into Haitian gangs as general election looms

A U.N. report details Haiti's gang-political ties and warns of violence, intimidation and child recruitment ahead of elections.

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Oct 10 • 1:09 PM EDT • Politics • haitiantimes.com
Apple's All-New Home Hub Will Be Revealed October 13: What to Expect

Apple reportedly plans to unveil an all-new smart home hub as part of the "Welcome home" product launch it announced for Tuesday, October 13. Our image above is just a rough concept based on rumored design details, so be prepared for the device's actual appearance to be different. The device will likely be unveiled in a press release shared on the Apple Newsroom website at around 9 a.m.

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Oct 10 • 9:58 AM EDT • Technology • macrumors.com
The Carolina Hurricanes’ hog mascot weighed in on Canadian politics during a game. Why?

Stormy, the Hurricanes' mascot, offered a detailed take on Vancouver's housing crisis and the government policies meant to address it.

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Oct 10 • 5:30 AM EDT • Politics • nytimes.com
Player Availability Report: #SKCvPOR

Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home this

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Oct 9 • 6:12 PM EDT • Sports • sportingkc.com
☹️ Negative (-5%)
love
100%
Bob Mackie’s death certificate reveals shocking new details after rep confirmed designer died of pneumonia

The fashion designer suffered a fall in the days before his death.

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Oct 9 • 4:48 PM EDT • Entertainment • yahoo.com
Apple acqui-hires AI startup founded by former NotebookLM developers

The European Union’s Digital Markets Act transparency site lists Huxe as Apple’s newest acqui-hire, and at least the fourth AI-related deal disclosed this year. Here are the details.

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Oct 9 • 4:04 PM EDT • Technology • 9to5mac.com
Leak Details iPhone Features for Apple's LG Home Accessories

Smart home accessories that Apple reportedly helped LG develop could offer iPhone proximity controls and a way to begin setup before the devices have power, according to findings shared by the leaker known as "pdfu". The findings concern the upcoming LG-branded accessory range that Bloomberg revealed earlier this week. The lineup reportedly includes a thermostat, temperature sensor, deadbolt lock, wired video doorbell, and several security cameras.

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Oct 9 • 10:50 AM EDT • Technology • macrumors.com
Hellraiser: Revival Gameplay Gets YouTuber Permanently Banned

It seems like showcasing Hellraiser: Revival gameplay could get you permanently banned on YouTube. Here are more details.

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Oct 9 • 10:28 AM EDT • Technology • insider-gaming.com
Ken Paxton took nearly 1,000 trips with state-funded security

The Texas attorney general’s use of a taxpayer-funded travel security detail stands out when compared with his predecessor and other state officials, our analysis found.

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Oct 9 • 6:00 AM EDT • Business • texastribune.org
Ace Combat 8 players in Japan are affectionately headcanoning its ace pilot protagonist as a helpless "airhead" outside the cockpit, thanks to clumsy story moments and awkward QTEs

In ACE COMBAT 8: WINGS OF THEVE, players take on the role of silent protagonist Rex, an ace pilot who racks up impressive achievements in aerial combat. However, a popular headcanon has recently been making the rounds among Japanese Ace Combat players, proposing (affectionately) that outside of the cockpit, Rex is actually a complete airhead. The idea was fueled by how the game’s interactive scenes work as well as certain moments in the story, with Rex gradually becoming the fandom’s beloved anemic baby. Note that this article discusses some details of Ace Combat 8’s main story. Ace Combat 8 is set in the franchise’s shared fictional world of Strangereal. In […]

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Oct 9 • 3:35 AM EDT • Technology • automaton-media.com
Apple rolls out AT&T carrier update for iPhone 18 Pro Max on iOS 27.2 beta

Apple is rolling out a different carrier bundle update for devices running the iOS 27.2 beta. Here are the details.

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Oct 8 • 10:11 PM EDT • Technology • 9to5mac.com
Researchers uncover new DarkSword spyware variant affecting unpatched iPhones

iVerify released a report today detailing P7 DarkSword, a new variant of the malware associated with the DarkSword iPhone exploit chain uncovered earlier this year.

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Oct 8 • 7:08 PM EDT • Technology • 9to5mac.com
Pretend you're sitting at Elizabeth Holmes' desk on this weirdly detailed website

With over a thousand emails, slides, texts, and documents from the United States v. Elizabeth Holmes trial, Extend engineer Bo Lau created a website that simulates what it might have been like to rifle through the Theranos founder's desk.

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Oct 8 • 5:00 PM EDT • Technology • techcrunch.com
Business Bulletin: BBB warns of healthcare fraud during open enrollment

If you or a family member are considering changes to your Medicare or Healthcare.gov coverage during open enrollment, your Better Business Bureau (BBB) urges you to be cautious of unsolicited calls, emails, and texts offering to help you find the best plan or deal. Scammers often take advantage of open enrollment to trick people into sharing personal information, Medicare or insurance details, and financial information.

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Oct 8 • 4:54 PM EDT • Business • timesfreepress.com
NC invests over $17M in mental health service grants

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 12:11 PM EDT • Health • foxcarolina.com
Natura’s $99 smart ring puts AI agents on your finger

Natura’s $99 Interface smart ring lets you summon AI agents with the press of a finger to complete tasks, capture thoughts, and control devices — while doubling as a health tracker.

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Oct 8 • 12:00 PM EDT • Technology • techcrunch.com
Payton Talks Details As Criticism Of Webb Continues

The Denver Broncos are taking plenty of heat for their play calling, but Sean Payton doesn't think that's the problem.

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Oct 8 • 7:42 AM EDT • Sports • sports.yahoo.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • newschannel10.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • wlbt.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • wtoc.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • kttc.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • fox8live.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • kptv.com
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • wkyt.com
😐 Neutral (0%)
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • wafb.com
😐 Neutral (0%)
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • kcrg.com
😐 Neutral (0%)
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • wdbj7.com
😐 Neutral (0%)
SC ranks second in measles cases as health officials urge vaccination

FOX Carolina's Anna Arinder has the details.

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Oct 8 • 7:33 AM EDT • Health • foxcarolina.com
😐 Neutral (0%)
Winless Titans fire three execs in front office shake-up

A detailed view of the Tennessee Titans logo is seen prior to Week 2 of a preseason game against the Seattle Seahawks at Nissan Stadium on Aug. 23, 2026, in...

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Oct 7 • 10:40 PM EDT • Sports • sports.yahoo.com
Joe Manganiello says local shaman healed him from deadly condition

In a new book, 'Bloodlines,' which drops Oct. 13, Joe Manganiello details a debilitating autoimmune disease that, he says, destroyed his marriage with Sofía Vergara and forced him to undergo 'major organ amputation.'

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Oct 7 • 6:49 PM EDT • Entertainment • latimes.com
Who Won August and September: Original Films or Franchises?

(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) I just heard someone say that if you’re reading a pundit or data analyst, and they don’t tell you that they got anything wrong, they’re not a pundit but an “influencer”. I agree with that. You have to tell your audience when you get things wrong, or they won’t (or shouldn’t) trust you as much. Today, we’ve got another edition of “What I Got Right, What I Got Wrong”. In general, I’m patting myself on the back (and patting very hard) about a few things like IP at the box office, LIV golf, horror films, crowdfunding movies, superheroes, and old people going to the theaters. That said, I also made a couple of data mistakes on the streaming bubble popping and HBO’s datecdotes, so I’m not perfect. But first, I need your feedback... Subscribe Follow-Ups: What Should We Call Mid-Budget Movies Which Aren’t Cinematic Enough for Theaters But Are Too Expensive to Make Money on Streaming? After I asked for feedback on what we should call straight-to-streaming films that are too big to pencil out on streaming but not really big enough to resonate in theaters, I got some great suggestions from you all, including... “Moldilocks” from John Aboud “Little Big Indie” from Travis Frick1 “Midflicks” from Jonathan Funke. “Extra-Medium” from Jona Nwuke. (Read the explanation in the footnote.) Between these and Brandon Katz—who suggested “Bermuda Budget Triangle”, “The Platform Gap” and “The Distribution Deadzone”—we’ve got some excellent suggestions. And they’re better than my suggestion, the “Streaming Budget Dead Zone”, so let’s take a poll! The winning entry becomes the new term. Loading... RIGHT: LIV Golf is Fully Bankrupt…Is Anyone Else Next? A few years ago, I was always a bit perplexed at all the articles I’d read praising LIV Golf and their strategy to disrupt the PGA. LIV Golf, a brand new professional golf league, offered PGA stars ten times what they made on the PGA Tour to join their new league. And folks praised this strategy for its initial “success” in that a lot of big names did indeed leave the PGA. Yeah, of course the players came over. LIV Golf paid them so, so, so much more! But LIV Golf hadn’t discovered a way to increase potential revenue. So think about this in basic business terms… They paid much more in costs… …but had no real way to increase revenue. That’s not a strategy! That’s deficit financing. It won’t work unless you bankrupt the competition (and then turn around and pay those same golfers much, much less). It’s not a sustainable strategy and only lasts as long as the company/person/nation backing it decides they’re cool with losing money. For LIV Golf, that meant Middle East oil wealth, in particular Saudi Arabian money. Clearly, the current Iran War has hurt Middle East finances, so they need to trim their more exorbitant spending. And LIV Golf was part of that trimming. This should be a major warning for others. TGL’s parent company, TMRW Sports, just got a $1 billion valuation, despite TGL’s (the indoor golf league) horrible TV viewership of less than half a million viewers per match. Unrivaled, the women’s basketball league, just secured a $650 valuation, despite its horrible TV viewership and a new rival (Project B) entering the scene next year. To relate this to streaming, Hollywood should ask which streamers may have wealthy patrons funding their losses. (Let’s be clear: Google, Amazon and Apple.) Could those patrons lose their appetite? For Amazon, probably not. But Apple has a new boss, so maybe! WRONG: My Analysis of the Streaming Bubble Was Missing a Week I’m going to be congratulating myself a lot today, but I make mistakes too, like this data goof. When I last compiled the data on the decline in TV shows, I was missing one week at the end of June. If you look at the first image, you can see that one week was mislabelled as “July”. Mainly, this image got updated to show a 27% decline, not 29%: This change doesn’t really impact the overall analysis, but it is two percent better. By the way, through the third quarter, the decline increased and it’s now a 30% decrease since 2022. (I’ll write/visualize this in an upcoming article.) But I want you to trust me and my data. Especially these days, when many people are using LLMs that I know are inserting faulty data into their charts, I want to keep earning my audience’s faith. So that’s the accurate data. RIGHT: IP Remains Very, Very Popular In July, I wrote a giant (and I mean giant) article on Backrooms, Obsession, and the box office, going over what we know, what we don’t know about what works in theaters, looking at YouTubers, IP, the horror genre, comic book movies, and a whole lot more. The month of August really tested a lot of my theses and, being honest, mostly supported my arguments. Let’s start with IP. Looking at 8-Aug (the weekend after Spider-Man: Brand New Day came out) to 18-Sep (the weekend that Resident Evil came out, which I think provides a nice bookend to this time period), there were seven films based on pre-existing IP: Resident Evil (2026) ($126 million) Practical Magic 2 ($65 million) _Insidious: Out of the Furthe_r ($65 million) Coyote Vs. Acme ($59 million) Paw Patrol: The Dino Movie ($53 million) Tony ($15 million) Super Troopers 3 ($7 million) Compare those to the notable original films from the past month—I actually could have included more movies, but here are just thirteen, bringing us to an even twenty films—including.... The End of Oak Street ($54 million) Buddy ($26 million) Mutiny ($15 million) By Any Means ($15 million) The Dog Stars ($14 million) Runner ($14 million) One Night Only ($11 million) Hope ($8 million) Spa Weekend ($7 million) The Uprising ($6 million) Teenage Sex and Death at Camp Miasma ($6 million) Onslaught ($3 million) Eli Roth’s Ice Cream Man ($2.8 million) Here’s that in chart form: Five of the top six films in this time period were all based on IP. I made a big chart of films that grossed over $200 million at the box office before Spider-Man: Brand New Day and The Odyssey hit theaters. Let’s update that chart! By the way, if you want to see how I categorized each film—so another bar chart—here it is: I know that many of my fellow critics/pundits/analysts dislike films based on IP and how Hollywood is making so many of them. And I’m sympathetic to this point of view. As I’ve written many, many times before, you need a balance between existing franchises, new IP, and original films. And Hollywood clearly needs to make more films like Resident Evil (a well-made film from a visionary director) and fewer Practical Magic 2’s (which didn’t get critical or customer buzz). But at some point, critics and pundits need to contend with what audiences are telling them: Movie-goers aren’t showing up to original films. Audiences are speaking with their dollars, telling you they want more IP and franchises. You can try to convince studio heads to make fewer IP-based films and franchises, but the data and numbers aren’t there. Instead, critics need to work harder to convince audiences to show up for original films. Aim your ire/concern at the average person, not studio heads.2 Because they’re just making the films that audiences are telling them to make. WRONG: Original Horror Films Didn’t Break Out I’ll be honest, even though I wrote an article casting some skepticism on the horror genre in July, if you asked me to make a prediction, I would have predicted that, in August, a new, original horror film would have blown up. No, seriously, I just assumed that Obsession and Backrooms presaged a change in audience behavior. But none of the buzzy new original horror films from August—Teenage Sex and Death at Camp Miasma, Onslaught (not an action film in spite of the ads), The End of Oak Street, Eli Roth’s Ice Cream Man, or _Buddy—_broke out. To be clear, exactly one of those films (Buddy) had good “ROI”, but again—I try to be specific in my language—none were “popular” in any broad sense of the word. None of them will be “saving” movies theaters like Backrooms or _Obsession_helped save the summer. The new Insidious film and Resident Evil, both based on IP, were far and away the biggest horror films since July. (We’ll see if this changes in October/Halloween season.) RIGHT: Stay Skeptical about Crowdfunding... I’ve long been skeptical about crowd-investing platforms as one of Hollywood’s saviors, mainly because there’s so much hype/buzz. People need to stay more skeptical about more things, explaining both the potential upside but also the downsides. In particular, the media often hypes crowdfunding at the start and never checks in on the actual results after they’ve come in later. And August gave us our first update! _Ice Cream Man—_directed by Eli Roth—grossed $6 million off of a $5.5 million budget. This is a production of The Horror Section, which was one of the first “crowd investing” studios with 2,400 investors, which means that 2,400 investors probably lost money. They certainly aren’t getting as great of returns as if they had just invested their dollars in the stock market. Hopefully Stiletto (Tagline: “Someone’s Going to Make it Rain Blood!”) does better next month. WRONG: Another Data Goof Here’s another data error. When the first episode of House of the Dragon came out, HBO put out that it had 21.5 million viewers in the first three days, and I read that to mean in the US…but no, it was global. So my US-only datecdotes charts shouldn’t have included it. We never got US-only numbers for the first episode, but for the final episode, HBO put out that it had 11 million US viewers. (And that global dropped to 21 million viewers.) Here’s the updated chart (which I’ve since used in the Streaming Ratings Report): Still, this show is absolutely huge. RIGHT: Superhero Films Remain Very, Very Popular After Supergirl flopped, I read a few takes that “comic book movies are going the way of the Western”. Post-Spider-Man: Brand New Day, that take didn’t age well. To be fair, I have a very nuanced take on the superhero genre right now; it’s down right now, for a lot of reasons. But it’s not “dead”. Maybe _Spider-_Man is just a really popular character? I saw that take, and it’s a fair counter-argument. (But pundits arguing that superhero movies were dead should have mentioned this $1.5 billion counter-argument…) But is it just Spider-Man? The next Avengers film already has $50 million in pre-sales (and I was skeptical that that film would do well) and the Avengers: End Game re-release topped the box office two weekends ago (over three original films). And I wouldn’t bet against Batman or Superman. So maybe it’s just Spider-Man, Batman, Superman and the Avengers. Oh, and Deadpool, of course. And Black Panther. And Wolverine. And probably the X-Men. Plus a well-made Wonder Woman or the Hulk film could break out. But that’s it! It’s just those ten characters/teams. Oh, what’s that? Lanterns is also doing well on HBO? (See previous section…) To be fair, I’m actually pretty sympathetic to the argument that more popular characters—like Spider-Man and Batman—anchor more popular films. In fact, I made that exact argument three years ago when I first wrote about the “Marvel-cession”. In many ways, you can blame The Guardians of the Galaxy for fooling Marvel Studios (and the rest of us) into believing that any character could pop. It turns out, the list of iconic characters is probably smaller than most people think. But it’s probably too early to say that superhero films and comic book movies are dead unless “death” means a slight decline over a longtime. RIGHT: Who Killed Theaters? Old People I get frustrated whenever I see headlines or analysis about how young people are “returning” to theaters. As I’ve detailed(for years), young people have always powered the US box office, despite narratives about “kids these days” and their “phones”. Really, what’s changed post-2020/pandemic is that old people aren’t going to the movies nearly as much. This summer, I saw a movie (from an older director) in a theater near a retirement community, and multiple older people at the theater were talking about how this was their first time seeing a movie in years. I dislike personal anecdotes, so YouGov can fill in the data, best summarized by this headline: “Who killed movie theaters? Not the youths”. According to them, 64% of people aged 18-29 have seen a movie in the last year, but only 30% of 65-and-older. 20% of 18-29 have seen a movie in theaters in the last week and 42% in the last month. Here’s the polling data: Most concerning? Many Americans (17%) think theaters are a worse or much worse experience than watching films at home. Slight WRONG: Hadestown Opens Big A live theater capture of the Broadway musical, Hadestown, made $20 million at the US box office, which begs the question: was I wrong to be skeptical about musicals a few years ago? Yes and no. On the one hand, $20 million is a far cry from being “popular”, so yeah, the genre isn’t that popular overall and Hadestown is one of the more popular musicals from recent years (i.e. the “Taylor Swift Data Fallacy” in action). On the other, I doubt filming this cost all that much, and I don’t think that they spent much on marketing, so this is a good source of ancillary revenue. Smaller Updates WRONG: As I mentioned in a Streaming Ratings Report, I underestimated the budget for Enola Holmes 3. It probably cost more like $50 million, if not more. But... I’m not sure that it really matters? At sub-10 million hours, prices have to come down to make this work. WRONG: Netflix is giving Ink a 27-day in theaters! To quote the kids/YouTubers these days, let’s go! Now I might actually have a chance to see Danny Boyle’s latest in theaters. I’d complained about this in a “Coming Soon” section, but I was heartened to read that Netflix is giving multiple films longer theatrical windows this year. RIGHT: Netflix is sending 4-5 films per year to theaters. Netflix is slowly but surely sending more and more films to theaters, as I cautiously predicted earlier this year. For now, it’s just three big films and a number of awards contenders, but still, this is great news. And they’ll be releasing box office grosses! Just this week, Ted Sarandos confirmed that KPop Demon Hunters 2 will come to theaters (and my guess is it performs in the box office top ten at a minimum). WRONG: Angel has 3 million subscribers! How do I know this? Well, they told Deadline, who reported it. I marked this as “wrong”, since they’ve doubled their subscribers in one year but, you know, they don’t really have a hit film to speak of and they’re still losing money. WRONG: Furious was only renewed for one more season. I accidentally wrote “two more seasons” in my latest “Renewals, Cancellations, Un-Orders and Removals Update”. RIGHT: House of David is ending with its third season. In July, Prime Video renewed House of David for a third season, as I just wrote in my latest “Renewals and Cancellations” report. Well, now it’s ending after that third season. Why? As I’ve been writing, its viewership wasn’t great. I got feedback that this show didn’t cost very much, but it cost enough that its limited viewership didn’t save it. WRONG: Adults was a Hulu original! So I missed Adults when it first came out last year; I saw that it aired on FX and just assumed that it was a linear-first program. Turns out, it aired three episodes on FX, but binge-released the rest of its episodes the next day on Hulu. Huh. So I should have covered it last year! But I just wrote about it. 1 “When I was a kid in the 90s, if you wore a t-shirt to school that wasn’t too big and also wasn’t too small, but somehow didn’t quite fit, we’d say you were wearing an “extra-medium” shirt.” 2 As always, a huge exception is Disney, which barely makes anything original anymore.

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Oct 7 • 6:41 PM EDT • Entertainment • entertainment.substack.com
Eagles Get Discouraging Saquon Barkley Update Despite ‘Not Major’ Injury

Philadelphia Eagles running back Saquon Barkley is dealing with a hamstring injury he suffered in Sunday’s 24-20 loss to the Los Angeles Rams. ESPN lists his status as questionable ahead of Week 5. Head coach Nick Sirianni gave no update on Monday and said more answers would come Wednesday. Despite the lack of official details, […] The post Eagles Get Discouraging Saquon Barkley Update Despite ‘Not Major’ Injury appeared first on Gridiron Heroics.

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Oct 7 • 6:29 PM EDT • Sports • sports.yahoo.com
The WHO seeks more details on the death of a plague research lab employee in Russia

The World Health Organization says it wants more information on what caused the death of an employee at a Russian plague research lab. Russia says the woman died of pneumonia of unknown origin.

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Oct 7 • 5:53 PM EDT • Health • npr.org
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Bobby Bones details how ‘DWTS’ allegedly decides performance order

Bobby Bones is sharing his theory about how the ‘DWTS’ performance order is determined: ‘They’re showing them off on purpose’

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Oct 7 • 5:22 PM EDT • Entertainment • ew.com
$138M project to expand behavioral health care in Greenville

FOX Carolina's Anna Arinder has the details.

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Oct 7 • 11:54 AM EDT • Health • foxcarolina.com
Microsoft Surface and Windows Event 2026: All the Announcements and Analysis Live From San Francisco

Today's the day! We hope to learn fresh details about the Surface Laptop Ultra, the next chapter for Windows, and the future of Copilot at Microsoft's fall event. Follow along with all of our expert commentary and on-the-ground updates, and tune in to the livestream later this afternoon.

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Oct 7 • 10:30 AM EDT • Technology • pcmag.com
Forza Horizon 6 PS5 Release Date Revealed

A new report confirms the PS5 release date for one of most highly rated games of 2026, Forz Horizon 6. Here are more details.

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Oct 7 • 8:11 AM EDT • Technology • insider-gaming.com
Atlassian Data Center Flaw Draws Exploitation Attempts Within Two Hours of Public Details

Attackers are exploiting an Atlassian Data Center flaw that enables unauthenticated access to specific webroot files.

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Oct 7 • 7:49 AM EDT • Technology • thehackernews.com
’80s icon Rick Springfield to preview new music at Riverside

At 77, Rick Springfield reflects on massive '80s fame, his battle with depression detailed in his memoir, and why he's still writing new music instead of just playing the classics.

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Oct 7 • 7:00 AM EDT • Entertainment • thegazette.com
Gaza, Sudan, Ukraine: Tracking Outbreaks Amid Conflict

War recovery plans should include detailed monitoring to prevent diseases like polio and cholera from spreading

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Oct 7 • 7:00 AM EDT • Health • thinkglobalhealth.org
Delaware details still slim as Penn Medicine plans new surgery centers

Penn Medicine unveiled a new plan to bring 18 ambulatory surgical centers to the region. Details remain slim on what's coming to Delaware.

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Oct 7 • 5:44 AM EDT • Health • delawareonline.com
WHO seeks details from Russia on media reports of a second lab worker with pneumonia

The World Health Organization said it ​had requested information from ‌Russian authorities on media reports of a ​second laboratory employee ​with pneumonia of undetermined cause.

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Oct 7 • 5:06 AM EDT • Health • reuters.com
Angus Taylor’s immigration plan misses the target – on politics and on policy

The most surprising aspect of the Coalition’s policy is that in six pages of detail there is not a single mention of the labour market

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Oct 6 • 6:47 PM EDT • Politics • theguardian.com
Freddie Jackson, known for '80s hits like 'You Are My Lady,' dies at 70

Details regarding arrangements will be announced in the coming days.

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Oct 6 • 4:55 PM EDT • Entertainment • spectrumlocalnews.com
Report: Cancelled Perfect Dark Project Over 2 Minutes of Gameplay Surfaces Showcasing New Zones and Combat

Last year, we reported on gameplay details and screens for The Initiative's Perfect Dark reboot, which was unfortunately canned by Microsoft. Today. we unearthed more about the project and its…

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Oct 6 • 4:33 PM EDT • Technology • mp1st.com
Black Tooth Business Park Final Plat

The Sheridan City Council met for their first regular business meeting of October Monday night. Sheridan Media’s Ron Richter has the details. A resolution for the final plat of the Black Tooth Business Park located at 3150 Heartland Drive in Sheridan was approved by the Council. City Planner Kelly Schroeder says the applicant, Heartland Assets, […]

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Oct 6 • 1:50 PM EDT • Business • sheridanmedia.com
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NeuroThera Labs Hires RK Strategies To Lobby on Health Issues

NeuroThera Labs hired RK Strategies to lobby on health issues, marking its first federal lobbying registration. Read the full filing for details today.

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Oct 6 • 12:30 PM EDT • Health • legis1.com
NASA’s Curiosity Rover Catches Stunning Martian Dawn

A newly released panorama captured by NASA’s Curiosity rover offers the most detailed view yet of distant, wind-carved Martian cliffs, highlighting features

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Oct 6 • 11:30 AM EDT • Science • nasa.gov
Deep dive
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New leaks reveal more details about the Fitbit Edge including its price

Google’s next fitness tracker with a screen could arrive soon.

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Oct 6 • 10:37 AM EDT • Technology • theverge.com
This Muskegon exhibit reveals the artistry and science behind observing nature up close

From detailed natural history illustrations to specimens drawn straight from the collection, the exhibit offers something for budding scientists, artists, and curious minds exploring how we document the world around us.

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Oct 6 • 9:55 AM EDT • Science • mlive.com
Exclusive Warhammer 40,000: Dawn of War 4 Space Marine Screenshots and Interview With Creative Director Jan Theysen

In this exclusive interview with director Jan Theysen, we go into detail on how the Space Marines actually work in Warhammer 40,000: Dawn of War 4.

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Oct 6 • 8:10 AM EDT • Technology • ign.com
As Halo Moves to Activision, Halo Studios Writers Tease What Might Have Been

Following the launch of Halo: Campaign Evolved, Halo Studios has put out a blog post detailing plans for the future of Master Chief’s story. It’s an interesting look at where the series might have gone, prior to the recent announcement that Activision is now the shepherd of the Halo series.

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Oct 6 • 6:18 AM EDT • Technology • ign.com
Netflix's 'East of Eden' cast explain 'poetic' final scene, 'Timshel' meaning

Spoiler alert! The following story contains major details about the "Timshel," the seventh and final episode of Netflix’s limited series “East of Eden” (now streaming).

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Oct 6 • 5:47 AM EDT • Entertainment • centraloregondaily.com
"This is Call of Duty's definitive extraction shooter experience" - Infinity Ward details the new DMZ mode in Modern Warfare 4

Infinity Ward has unveiled ambitious plans for Call of Duty: Modern Warfare 4's extraction mode, DMZ.

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Oct 6 • 4:57 AM EDT • Technology • eurogamer.net
Will Dawkins on AJ Dybantsa, Ending Wizards' Deconstruction Phase

From scouting character to ending the teardown, Washington Wizards GM Will Dawkins details the vision behind drafting AJ Dybantsa and how the franchise is finally shifting toward competitive growth.

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Oct 5 • 8:54 PM EDT • Sports • sports.yahoo.com
1 killed, 2 injured when car crashes into Santa Fe Springs business

One person died and two people were injured when a car crashed into a business Monday afternoon in Santa Fe Springs. The crash was reported at about 2:30 p.m. near Telegraph Road and Slauson Avenue in the community about 15 miles southeast of downtown Los Angeles. Details about what led to the crash into the front of the building, possible…

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Oct 5 • 6:26 PM EDT • Business • nbclosangeles.com
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What’s new in Android’s October 2026 Google System Updates

The monthly “Google System Release Notes” primarily detail what’s new in Play services, Play Store, and Play system update across...

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Oct 5 • 5:17 PM EDT • Technology • 9to5google.com
Infinity Ward Details Call of Duty: Modern Warfare 4's Extraction Mode, DMZ

Call of Duty: Modern Warfare 4's ambitious new extraction mode, DMZ, has gotten a massive deep dive from Infinity Ward.

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Oct 5 • 4:51 PM EDT • Technology • ign.com
US says foreign financial institutions doing business with Iran may be sanctioned without notice

WASHINGTON, Oct 5 (Reuters) - The US Treasury Department said on Monday it was alerting foreign financial institutions that continue ‌to do business with Iran or its financial sector that they ‌may be sanctioned by Washington without advance notice. DETAILS: • "Foreign financial institutions continuing to transact with sanctioned ​Iranian financial institutions could be targeted at any time without advance notification and should take immediate action to terminate such activity and relationship

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Oct 5 • 4:29 PM EDT • Business • finance.yahoo.com
El-Sayed explains what he means by getting the money out of politics

Michigan Democratic Senate nominee Abdul El-Sayed details his Medicare for All plan while advocating for politicians to not take money from big corporations on ‘The Story.

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Oct 5 • 4:14 PM EDT • Politics • foxnews.com
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027

The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.

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Oct 5 • 3:26 PM EDT • Business • bizfayetteville.com
T.J. Holmes and Amy Robach's wedding details are revealed

T.J. Holmes and Amy Robach's wedding plans are taking shape.

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Oct 5 • 3:05 PM EDT • Entertainment • centraloregondaily.com
State leaders detail plans to support HUSKY Health D recipients ahead of new rules

State leaders shared plans today to support people who get their health insurance through HUSKY Health before new rules start next year.

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Oct 5 • 1:00 PM EDT • Health • wfsb.com
CD Projekt Red Isn’t Done With The Witcher 3 Remastered, Lining Up PS5 Performance Fixes After Two Quick Patches

CD Projekt Red details upcoming The Witcher 3 Remastered fixes, performance patches, and cross-platform mod support.

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Oct 5 • 10:55 AM EDT • Technology • wccftech.com
Bruno Guimaraes Details Heavy Brazil Workload Ahead of Arsenal Return

Bruno Guimaraes has revealed the amount of travelling Brazil faced during a demanding international window before his return to Arsenal.

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Oct 5 • 8:43 AM EDT • Sports • sports.yahoo.com
Heartland Catfish Unveils New Website

Heartland Catfish Company recently launched a new website in celebration of its 30th anniversary. The site has been refreshed to focus on retail and food service partnerships, give a detailed look at the company’s products and processes and emphasize consumer education about the benefits of U.S. Farm-Raised Catfish as a versatile and healthy protein source. […]

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Oct 5 • 8:04 AM EDT • Business • deltabusinessjournal.com
Capcom Plans to Use AI Technology with RE Engine to Make Games More Efficiently

REX initiative detailed

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Oct 5 • 7:30 AM EDT • Technology • pushsquare.com
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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