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New PlayStation Patent Aims to Make Wait Times in Games Less Boring With Picture-in-Picture Content
Sony has filed a new PlayStation patent that should make waiting for games to load or matchmaking to finish a lot more bearable.
Redistricting shuffle: James Martin stays put as new money leader in CD 21
Both he and Bernard Taylor will stay in the race as Pia Dandiya shifts to a neighboring seat.
The Surprising Mental-Health Benefits of Bedazzling
Bedazzling transforms boring objects—and possibly your mood, too.
LinkedIn Doesn't Want Your AI Slop Anymore
It isn't just lazy. It's also mind-numbingly boring.
What to know about the Ebola outbreak now declared a global health emergency
ABUJA, Nigeria (AP) — The World Health Organization declared Sunday the Ebola disease outbreak in Congo and Uganda a public health emergency of international concern. Africa’s top public health body first confirmed a new Ebola outbreak in Congo’s Ituri province on Friday. By Saturday, it had reported 336 suspected cases and 88 deaths. All the cases are in Congo, except for two recorded in neighboring Uganda. Health authorities say the current outbreak is caused by
Rutherford Co. invites frustrated Nashville businesses south as property tax concerns grow
After rising property taxes sparked concern among some Nashville business owners, a neighboring county is encouraging frustrated businesses to look elsewhere.
This is California's most interesting governor's race in ages
Far from boring, the contest is the most wide open in a generation, with a potential to make history in November. Those yawning at the contest may be looking for glitz and entertainment. Voters aren't.
Millington Trackside Bar & Grill serves up food and entertainment
MILLINGTON — Residents of Millington and folks in neighboring areas have a new place to go for “great food, cold drinks and good company.”
Scientists unlock fungi's secret chemistry, offering a greener path to crop protection
Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect and ultimately kill the ...
Scientists unlock fungi's secret chemistry, offering a greener path to crop protection
Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect ...
The Spurs are back, plus the unicorn recipe for firing a coach
The Pulse Newsletter 📣 | This is The Athletic’s daily sports newsletter. Sign up here to receive The Pulse directly in your inbox. Good morning! I’m thinking about Chonkers this morning. Coming up: 🤠 Spurs look unstoppable 👀 Escaping the buyout trap 🙏 RIP, Ted Turner We had multiple playoff games again in both the NBA and NHL last night. They can be divided into two sections: interesting games and interesting results. Follow me here, starting with results: NBA: Spurs 133, Timberwolves 95. Boring game, as San Antonio was up 20 in the second quarter. Interesting...
Trophies or entertainment? Jose Mourinho conundrum facing Newcastle as Chris Waddle explains winning versus ‘boring’ balancing act
Jose Mourinho rumours refuse to go away at Newcastle, as questions are asked of Eddie Howe’s future, and Chris Waddle has told GOAL why any club considering a move for the ‘Special One’ must mull over the “win trophies or entertain” conundrum. Mourinho boasts several major honours on his glittering CV, but the ex-Chelsea and Real Madrid boss has faced accusations of being “boring” at times.
The politics of Trump's ballroom
WEST PALM BEACH, Florida — President Trump was about a half-hour into his second speech of the day, musing about the danger he faced last week at the White House Correspondents’ Dinner. “Saturday night, it was good for one thing. People are loving my ballroom now,” Trump told a crowd last night. “That’s the only thing. They love my ballroom.” Ever since he was hustled off stage at the Washington Hilton last week, after an attempted shooter breached the dinner’s security perimeter and sent guests diving to the floor, the president has argued that the incident is proof for why his White House ballroom is needed. Only his planned $400 million, 90,000-square-foot project, Trump has reasoned, can keep a president truly safe at major events. It’s true that a bunch of GOP lawmakers have jumped on board with new legislation and words of support for Trump’s project. House Speaker Mike Johnson, Sen. Rand Paul and other prominent Republicans went on TV to talk about the need for a ballroom. But as we reported at The Washington Post this week, “people” aren’t really changing their minds on Trump’s ballroom. A new Post-ABC News-Ipsos poll found that most Americans still oppose the ballroom project: 56 percent against it versus 28 percent in favor. The numbers are the same as a poll from last year, the Post’s polling whiz Scott Clement found. Other new polls have found similar margins, too. “I’m just not a giant fan, especially of extravagance,” one independent voter told me. “I mean, in the era we’re in right now, given how much people are struggling, it just doesn’t make a lot of sense to me to spend $400 million on a ballroom.” How we got here The Washington Post has followed Trump’s ballroom project very closely. (My colleague Jonathan Edwards may have written the most total words of any reporter about the project; I may be second.) The project exploded as a national issue after Trump tore down the White House’s East Wing after initially promising not to touch it.1 Historic preservationists sued, and about a month ago, a federal judge ordered a halt to ballroom construction.2 The only way the ballroom could proceed, U.S. District Judge Richard Leon ruled, was if Congress explicitly authorized Trump’s plans. (An appeals court has stayed Leon’s order for now.) The judge’s ruling raised an obvious question: would Congress authorize the project? Keep in mind, “authorization” doesn’t mean that Congress needs to necessarily fund the planned $400 million project; they could just sign off on the private donations that Trump has solicited to pay for the ballroom.3 But GOP lawmakers really didn’t want to talk about the ballroom, we reported at The Post just a few weeks ago. One major reason was the ballroom’s bad polling — not a small detail with many of their own midterm elections looming. The White House Correspondents’ Dinner incident, and Trump’s advocacy, may have changed the political conversation around the ballroom. As this week’s polling shows, it doesn’t seem to have affected the fundamental questions surrounding the project. To put it another way, voters still say that cost-of-living concerns are top-of-mind heading into the midterms. Some Republican and independent voters have told me that they see the ballroom as a vanity project that will help Trump but do nothing for their own lives. It might not help Republicans that Trump has dismissed some of the cost-of-living concerns. He’s described “affordability” as a buzzword manufactured by Democrats whose policies helped cause inflation. “They’ve got one good line of bullshit,” Trump said in his first speech yesterday, delivered at a Florida retirement community known as The Villages. Thanks for reading Dan Diamond's newsletter! Subscribe for free to stay up-to-date on my work. Subscribe Speaking of Trump’s speeches… I’m down in Florida because it’s my “duty week” as a White House reporter — basically, I follow the president wherever he goes. (And then hand the baton off to one of my Washington Post colleagues next week.) As part of my duty week, I’ve spent a few days covering the White House’s reaction to Saturday’s attempted shooting, including officials’ review of the security protocols to protect the president. Trump was restrained in the wake of the incident, addressing the nation from the White House briefing room about the need for peaceful dialogue and trying to lower the temperature. But he’s clearly been itching to get back out of the White House, and I was curious to hear how his Florida speeches would go. And — to my ears — it was an unburdened Trump. Not the one we saw Saturday night in the White House briefing room, but the one we witnessed on the campaign trail in 2024. Loose, dropping profanities, mocking everyone, including members of his team. “We have a man here who knows more about Medicaid, Medicare, medical crap than any human being. Where’s Dr. Oz? Where the hell are you, stand up,” Trump said, referring to Mehmet Oz, the administrator of the Centers for Medicare and Medicaid Services. “It’s the most boring trip I’ve ever made. He’s telling me about Medicare, Medicaid. All I want to do is take care of you, I don’t care. I said, ‘You work out the details.’” I wrote up the speech, as Trump headed to West Palm Beach to deliver more remarks a few hours later. The White House didn’t like my story. Their rapid-response team called it the work of a “total loser”4 and “a miserable TDS-ridden moron.” You can be the judge of whether it’s a fair story or the product of someone afflicted with “TDS.” (The White House’s shorthand for “Trump Derangement Syndrome.”) I’ve pasted the story below with a gift link, meaning that you don’t need to be a Washington Post subscriber to read it. It might prompt you for an email address, though. Meanwhile, I’ll be down in Florida for the rest of the weekend, covering the president. It’s TBD whether those stories will be deemed TDS-afflicted, too. 1 Jonathan details the past six months of ballroom fallout, reactions and the implications for executive authority here. I also had a great time talking about Trump’s ballroom and other projects with Australia’s ABC News Daily on a podcast this week. 2 The judge allowed underground construction and national security-related work to continue. But that hasn’t been enough for Trump, who says the ballroom itself is essential for his protection. 3 The ballroom donors include companies like Palantir, Google and Amazon. For transparency, Amazon founder Jeff Bezos owns The Washington Post, where I work. No one has ever interfered with our team’s coverage of the ballroom or our mentions of Amazon or Bezos, and if that changed, I’d speak out. 4 To be fair, I’ve spent the morning working on stories and writing this Substack post rather than enjoying the beautiful Florida weather. So they may be onto something about who’s winning and who’s losing.
Venezuela and Colombia: Immigration Options for Global Employers Renewing Business Activity in the Region (Video Chat)
Our attorneys examine how Venezuela and key neighboring jurisdictions—particularly Colombia—are reshaping immigration, employment, and workforce
Motorola Signature design highlight: Striking the perfect balance between form and function
This phone may look quite familiar, but it also proves that boring can be beautiful when executed this well.
The Tech Elite Sure Have a Boring—and Expensive—Idea of Immortality
If you’re one of the lucky few who can afford to live forever, at least do something more interesting than measuring the “quality and durability of nocturnal erections.”
Google’s new gradient icon design is coming to more apps
So long to the boring “things in a circle” look.
iPhone 18 Pro Max design unit hands-on video shows 25% smaller Dynamic Island; variable aperture likely
Hands-on video of the iPhone 18 Pro Max dummy units reveal a 25% smaller Dynamic Island and a thicker camera array with larger lenses, hinting at the rumored variable aperture for the main 48MP camera. The iPhone 18 Pro Max appears boring next to iPhone Ultra/Fold, but this might be the biggest front upgrade for Apple's Pro iPhone since iPhone 14 Pro.
Got $5,000? This Boring Waste Business Might Be a Quiet Multimillionaire Maker by 2036.
Republic Services is in the business of trash, but its long-term potential is anything but junk.
Despite Mize's Brilliance, Detroit Loses A Pitching Duel In Fenway
That was one of those ball games that separates the diehards from the casual fans. I’m sure that there will be people who look at the final score and think that that game was “boring“, but for me, that’s about as entertaining as they come. It’s another night in which the Tigers played a low-scoring game with two starting pitchers who were featuring their best stuff.
Scientists discover bacteria can “explode” to spread antibiotic resistance
Scientists have uncovered a surprising twist in how bacteria share genes—including those that spread antibiotic resistance. Tiny virus-like particles called gene transfer agents (GTAs), once ancient viral invaders, have been repurposed by bacteria into delivery systems that shuttle DNA between neighboring cells. The study reveals a key control hub of three genes, dubbed LypABC, that triggers bacterial cells to burst open and release these DNA-packed couriers.
Colorado cannot afford to get the Colorado River wrong
By Larry Don Suckla Colorado and our neighboring states are standing on the edge of a crisis that is no longer theoretical. The Colorado River, the lifeline of the American west, is facing conditions that demand immediate, responsible action. If we fail to act wisely, the consequences will not just be environmental. Right now, the […]
Ending Relationships Over Politics Has Become Boring
We all need to calm down and relearn how to agree to disagree.
Ishbia family taking swing at youth sports facility for vacant Office Depot
(Editor’s Note: Alex Harrison Perry reported this story for Evanston RoundTable, a neighboring independent newsroom. It was shared with The Record as part of an ongoing collaborative effort.) The vacant Office Depot building at 2722 Green Bay Road — just a block south of Wilmette — could become a year-round site for youth sports, as a North Shore family […]
She was in active labor and refused a C-section. The hospital took her to court.
In a recording of the hearing obtained by ProPublica, the laboring patient Cherise Doyley called it “the craziest thing I’ve ever seen.\
We all need to become better science storytellers. Here’s why and how.
Last week, in a lovely New Haven bar, six people gathered in front of a crowd to tell stories that were somehow related to science and public health. It was magical. One person talked about learning how social determinants of health helped them forgive their mother’s alcoholism. Another shared what it’s been like navigating a dementia diagnosis. Another described their last dinner with their mother before they left Nigeria to come to the U.S. and how that moment, plus the diagnosis that followed, shapes their career goals today. As the Executive Director of The Evidence Collective at Your Local Epidemiologist, I was ecstatic to bring this event, “Science and Storytelling,” to the community surrounding the Yale School of Public Health. Stories are not the default way most people communicate about science and public health. In fact, we are taught to take all the emotion out of data, but that makes it pretty darn boring to everyone else. And if people can’t see themselves in it, feel themselves in it, or influence it, how can we ask them to support it? Why do stories stick? How can we all—from community members to public health scientists—do better? And what are some examples?
Nebraska baseball hangs on against Creighton despite bullpen drama
Nebraska baseball’s success in midweek games is starting to feel routine, though there’s been nothing boring about the way the Huskers have rolled to a 7-0 mark in those contests this season.
Neighboring businesses react to possible arson after Petersburg house fire
An arson investigation is underway after a large house fire in Petersburg Sunday afternoon.
Silencer Central acquires vacant Wells Fargo building for future growth
A former Wells Fargo call center is off the market -- bought by its neighboring business for future growth.
Hingham Schools Eye Business Curriculum Expansion as Class Size Concerns Mount
HINGHAM - March 23, 2026 - The Hingham School Committee moved to modernize its high school offerings Monday night, reviewing a comprehensive plan to expand the “small but mighty” Business Department while simultaneously grappling with data that places Hingham as an outlier in elementary class sizes. Director of Social Studies Andy Hoey presented a two-year program review that highlighted the department’s success in community partnerships but warned that high student demand is testing current staffing limits. Meanwhile, committee Chair Jen Benham presented independent research showing Hingham is the only benchmark district with second-grade classes hitting a 25-student cap, sparking a directive for the Policy Subcommittee to review class-size standards. Editors note: South Shore News is going paid in April, subscribe now to make sure you don’t miss a story. Reach out for group or organizational pricing. Subscribe The Full Story The meeting opened with a look into the future of Hingham High School’s (HHS) curriculum. Andy Hoey, who oversees the Business Department, presented the first formal program review for the department since 2009. [15:09] Hoey characterized the department as a vital elective hub that currently serves between 14% and 27% of the HHS student body in any given year. [31:31] “We are very proud of our business department here at Hingham High School... while we’re very proud of it, we are always striving to make improvements and enhancements.” [15:55] — Andy Hoey, Director of Social Studies A key highlight of the presentation was the announcement of a new AP Business with Personal Finance course launching next year, pending enrollment. [20:08] The review team found that while the program is “well-aligned” to national standards, it remains a high-school-only offering. Hoey outlined an action plan to explore “vertical articulation,” potentially introducing business or financial literacy units at the middle school level to fill a “gap” identified between fifth and eighth grade. [41:48] However, the department faces “smoke and mirrors” regarding student GPA, according to Hoey. Currently, most business courses are “unleveled” and do not count toward a student’s GPA, which survey data suggests may deter some students from enrolling. [28:15] The committee discussed the possibility of offering Honors or College Prep (CP) credit for advanced courses, such as investing or marketing, to better reflect their academic rigor. [38:27] The discussion took a sharp turn toward elementary education during an enrollment update. Superintendent Dr. Katie Roberts noted a net gain of four students mid-year, but it was Jen Benham’s “rabbit hole” data analysis that caught the committee’s attention. [50:35] Benham researched 13 benchmark towns—representing 34 elementary schools—and found that Hingham was the only district with a second-grade section reaching 25 students this year. [51:36] Benham’s findings suggested that while many districts lack formal class-size policies, Hingham’s current cap of 25 for second grade may be too high. “I think if we could at least have 23 at a cap for grade two,” Benham suggested, noting the importance of that grade level for literacy development. [53:09], [54:55] Dr. Roberts cautioned that smaller classes require more staff, which is a significant hurdle following a budget season where nine general education positions were cut across the district. [55:56] The committee also finalized the 2025 Town Report, which was updated to be more “student-centered” and highlight staff early in the document. [11:12] Additionally, a series of food service policies were approved to align with Massachusetts’ universal free school meal mandate, including new protocols for meal modifications due to allergies or religious needs. [59:23] Share Why It Matters The meeting underscored a tension between Hingham’s desire to offer elite, specialized programming and the foundational pressure of class sizes. The expansion of the Business Department—including potential Microsoft certifications and AP courses—aims to prepare students for a “real world” where credit scores and financial literacy are paramount. [46:20] However, the revelation that Hingham’s second-grade classes are larger than those in all neighboring benchmark towns suggests a potential strain on early education that could impact long-term student performance if not addressed by the Policy Subcommittee. Official Minutes & Data Key Motions & Votes Motion: To approve the Hingham Public Schools 2025 Town Report. [13:16] Vote: Unanimous (7-0) ([01:13:28]) Motion: To approve the Memorandum of Agreement (MOA) for summer counselor work regarding course placement. [57:33] Vote: Unanimous (7-0) ([57:50]) Motion: To approve Policy EFBA (School Food and Nutrition/Meal Modifications). [01:00:32] Vote: Unanimous (7-0) ([01:00:44]) Motion: To approve Policy EFC (Universal Free School Meals). [01:00:54] Vote: Unanimous (7-0) ([01:01:07]) Public Comment No members of the public spoke during the meeting or via the remote link. [01:02:30] What’s Next The Policy Subcommittee will take up the review of elementary class-size caps over the next year to determine if the Grade 2 limit should be lowered from 25 to 23. [52:18] The Business Department will monitor enrollment for the new AP Business course and continue exploring dual-enrollment partnerships with Quincy College. [38:13] Source Video: Harbor Media South Shore News is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
Apple is absolutely on the right path with the boring iPhone 18 Pro design
A recent survey reveals that most people don’t think the iPhone 18 Pro must come with a redesign.
'Claude, Resize These Photos' - Anthropic's Agentic AI Will Run Photoshop For You
It can perform boring tasks.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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