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Mag Mile recovery gains momentum with a drop in vacancy and infusions of capital
North Michigan Avenue's availability rate ticked down about 3% year over year, continuing the shopping strip's recovery as foot traffic and retailers return.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Utah Royals
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Sunday's home match vs Utah Royals
Big Ten will have four "availability reports" per week
As sports betting continues to proliferate, college football is taking more steps aimed at minimizing inside information.
Player Availability Report: #SKCvVAN
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home this
Louisiana fertilizer plants lay off 200 as war with Iran drives up cost of key raw material
The company said it is reducing staffing at the plants in Convent and St. James, because of the availability and cost of sulfur, one of the key components of phosphate fertilizer production. Ammonia production at the Faustina plant in St. James will not be affected.
Louisiana fertilizer plant lays off 200 as war with Iran drives up cost of key raw material
The company said it is reducing staffing at the plants in Convent and St. James, because of the availability and cost of sulfur, one of the key components of phosphate fertilizer production. Ammonia production at the Faustina plant in St. James will not be affected.
More than 200 employees laid off at St. James Parish fertilizer plant
The company said it is reducing staffing at the plants in Convent and St. James, because of the availability and cost of sulfur, one of the key components of phosphate fertilizer production. Ammonia production at the Faustina plant in St. James will not be affected.
ASUS Announces Availability of the Chromebook CM32 Detachable for Business and Education
Fremont, CA, Aug. 28, 2026 (GLOBE NEWSWIRE) -- ASUS, a global technology leader that provides the world's most innovative and intuitive devices,...
FDA just approved updated covid shots. Here’s what to know as cases rise.
Questions remain over formal federal recommendations for which Americans should get a vaccine, which could complicate availability of the shots in a handful of states.
Microsoft finalizes Windows 11 version 26H2 for general availability: Next version of Windows 11 enters final preview phase before rollout begins
Microsoft has announced that Windows 11 version 26H2 is now available to test in the Windows Insider Release Preview Channel, which means general availability is imminent.
Sam Altman says scrolling through his inbox makes him feel productive
Sam Altman, CEO of OpenAI, said he prefers to manually handle his emails, despite the availability of AI tools like Codex.
The Business of Broadway: Star-driven shows increase prices, demand this fall
If you want to stay ahead of the Broadway market, and get some good choices and availability, act in the next week or so.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at Washington Spirit
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Sunday's away match at Washington Spirit
Jaguars WR Meyers Jams Right Hand, Could Miss Joint Practice
Jacksonville’s training camp injury woes continue as Trevor Lawrence’s top target faces a sideline stint, threatening his availability for high-stakes preseason repetitions against the Buccaneers.
Player Availability Report: #ATLvSKC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City hits the road
Availability report: 5-Stripes finding health heading into Sunday match
Atlanta United has just two players unavailable for Sunday night's clash with Sporting Kansas City
Apple is reportedly cutting hundreds of jobs from Siri, Vision Pro teams
Apple has admitted that some roles are being impacted as it shifts its focus away from certain initiatives.
Small Towns, Big Care: Three Rivers Hospital Tackles Rural Health Access on "All Access hosted by Andy Garcia"
Healthcare availability in isolated regions faces unprecedented operational strain as small facilities close nationwide. Filmed on location on August 13, 2026, a new feature from "All Access hosted by Andy Garcia" highlights how Three Rivers Hospital maintains comprehensive, 24/7 care across a remote service territory. The Public Television segment illustrates how a facility established by local residents decades ago continues to serve as an independent medical hub. Through continuous quality pr
Why Manufacturers Are Paying Closer Attention to Building Envelopes
Site selection teams have to be meticulous. They model tax incentive schedules years into the future, track labor availability across competing markets, and negotiate access to highway interchanges and rail spurs.
Player Availability Report: #SKCvSTL
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home this
iPhone Ultra leakers reveal new details around release and 'extremely limited' availability
Bad news for early adopters
New iPhone Ultra leaks cover release timing, availability, and name
Apple’s foldable iPhone Ultra will be unveiled soon, and new leaks cover expected release timing, availability, and the product’s name.
SAPPHIRE unveils Radeon RX 9070 XT NITRO+ VCT CN 2026 edition
SAPPHIRE has another themed RX 9070 XT, this time based on the 2026 VALORANT Champions Tour. Pricing and wider availability have not been announced.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at Portland Thorns
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Saturday's away match at Portland Thorns
Player Availability Report: #COLvSKC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City is back in
American Express Expands Virtual Cards for Corporate and Business Travel Spending
American Express is expanding the availability of virtual cards for businesses, as more companies use digital payments to manage expenses and reduce
'iPhone Ultra' Could Face Staggered Country Rollout Like Vision Pro
Apple's foldable "iPhone Ultra" may get a Vision Pro-style staggered country-by-country launch over several months, with initial availability limited to the U.S. market, according to an Australian publication. In a report labeled "exclusive," ChannelNews said today it has been told by local carriers and one major retailer that Apple's first foldable iPhone will be a "no show" when the iPhone 18 Pro models launch in September, despite being unveiled together.
Advancing the science of dietary nitrate with integrated vascular assessment
Standardised beetroot-derived dietary nitrate supports endothelial function, arterial compliance, central haemodynamics and nitric oxide bioavailability, thereby promoting systems-based research in vascular nutrition
Agency offering disaster loans to businesses
The U.S. Small Business Administration has announced the availability of low-interest federal disaster loans for eligible small businesses and private nonprofit organizations impacted by ongoing drought in areas of the
Beyond Flashpoints: Understanding the Politics Behind Taiwan’s Strategic Choices
Written by Lucy Best. This article argues that issues of everyday governance, such as budgets, industrial development, and energy availability, that underpin Taiwan’s strategic success have b…
OC Jim Bob Cooter discusses health at wide receiver | 2026 Training camp media availability
While unfortunate to have veteran players out for a day or two, the Colts offensive coordinator appreciates the chance to better evaluate younger players who now get a chance to run routes they might not otherwise.
Best Launch Deals for Galaxy Z Fold 8, New Galaxy Watches
It's national availability day for Samsung's new Galaxy Z8 series and new Galaxy smartwatches. The deals for these devices change ever so slightly when going from pre-order to general...
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Racing Louisville
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Racing Louisville
Patriots QB Drake Maye shares early update on preseason availability
Patriots quarterback Drake Maye commented on the team's plans for his preseason snaps.
Xbox Disc to Digital Arrives This Month for Xbox One and Series X
Microsoft's internal roadmap for the Disc to Digital feature has been leaked, revealing that the feature will be generally available this month. According to the roadmap, an insider beta of the Disc to Digital feature has been available since July, with general availability for Xbox One and...
The global memory shortage hits the MacBook Air
The global memory chip shortage appears to be affecting the availability of Apple’s most popular Mac.
Player Availability Report: #SKCvHOU
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home this
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at North Carolina Courage
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's away match at North Carolina Courage
Tanor Bortolini and Charvarius Ward Sr. on team's health, near-retirement decision | 2026 Training camp media availability
Center Tanor Bortolini breaks down how Daniel Jones' return from injury helps the offensive line and the communication the group has with the quarterback. Then, cornerback Charvarius Ward Sr., joined by a special guest, discusses how he was 85% sure he wa
The Hunter Greene trade rumors just won’t stop
Unsurprisingly, teams around the league are asking about Greene’s availability in trade.
Rural Virginia has been kind to the GOP, yet Trump’s GOP allows rural healthcare to suffer
Policies put in place during President Donald Trump’s second term contribute substantially to the declining availability of medical care in the rural communities of the commonwealth — the same communities that are, by far, Trump’s strongest base of support, writes columnist Bob Lewis.
Google Maps "2026 Update" Now Rolling Out, Also Available on Android Auto and CarPlay
Immersive navigation started showing up for more users, though the availability is limited to some region, most of them in the United States
Player Availability Report: #LAFCvSKC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City has a quick
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Chicago Stars FC
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Chicago Stars FC
Player Availability Report: #SKCvMIN
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home for
Local food policy panel seeks two new members with healthcare backgrounds
The commission is designed to integrate the public and private sectors into an effort to improve food availability.
Fake Spa Listings Take Deposits, Then Send Customers to Real Businesses
Customers searching online for a late-night massage around Jackson, Mississippi, are finding spa listings with real street addresses, glowing reviews, and around-the-clock availability. The businesses...
NEW NFIB REPORT: Texas Small Businesses Report Insurance Challenges Five Points Worse Than National Average
State-specific report finds insurance affordability and availability concerns are five points worse in Texas than across the country
Tarik Skubal landing spots: Eight teams that could land ace at deadline (and why the Tigers may just keep him)
The Tigers ace is the hottest commodity on the market leading up to Aug. 3, but his availability isn't a sure thing
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at Utah Royals
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Saturday's away match at Utah Royals
Stephanie White Praises Caitlin Clark's Historic 45-Point Game Performance
Caitlin Clark dominated headlines following her historic game against the Seattle Storm. Many couldn't believe what they witnessed, including Stephanie White. During her postgame availability, the Indiana Fever coach discussed the superstar guard's performance.
Player Availability Report: #STLvSKC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City resumes the 2026
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Boston Legacy FC
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Wednesday's home match vs Boston Legacy FC
Bryce Harper Makes Honest Statement About Yankees Star Aaron Judge
Bryce Harper and Aaron Judge are two of the most notable stars in all of baseball.Both players are 2026 MLB All-Stars, but Judge has been out with an injury since May 31.At his recent media availability on Monday, Harper made an honest statement about Judge (h/t SNY Yankees).Reporter: “What’s one player in MLB history you’d […] The post Bryce Harper Makes Honest Statement About Yankees Star Aaron Judge appeared first on HEAVY.
Data Sharing in Life Sciences: How to Share Research Data Without Sharing What You Shouldn't
Discover how to manage research data sharing in life sciences, covering NIH and UKRI funder mandates, GDPR compliance, embargoes, and data availability rules.
Why GameCube games are so expensive (and why they're rarely sold at retro stores)
GameCube game sales didn't come close to those of the Nintendo 64 or Wii, so scarcity plays a major role in the titles' high prices and lack of availability.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Kansas City Current
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Kansas City Current
Ohio children unable to access mental healthcare because of insurance, costs, and lack of providers
Costs, provider availability, and health insurance limitations were the top reasons Ohio children were not able to access mental healthcare, according to a recent study.
Digital Health Tools and Technologies: An Overview of CMS’ Recent Efforts to Expand Their Use in Medicare
As an increasing share of older adults have adopted digital health technologies over the past several years, and with most expressing interest in using them to manage their health care, the Centers for Medicare & Medicaid Services (CMS) has introduced several initiatives to expand the use of digital health technologies in Medicare. This brief summarizes these initiatives and draws on data from various surveys, including KFF Tracking Polls from September 2025 and March 2026, to highlight facts about recent experiences with and use of digital health tools among Medicare beneficiaries and older adults more generally.
Nintendo confirms plans to continue selling Switch 1 outside of Europe
Following yesterday’s news pertaining to Europe, Nintendo has confirmed that the original Switch will continue to be sold in all major regions. A couple of announcements were made yesterday. One thing we heard is that Nintendo Switch will no longer be sold in Europe starting in early 2027. It wasn’t entirely clear what would be happening elsewhere. Nintendo didn’t provide...
Report: iPhone Ultra to have incredibly limited availability at launch, may ship slightly later
According to supply chain analyst Ming-Chi Kuo, Apple is likely to have very limited supply for iPhone Ultra at its...
AYANEO NEXT 2 Strix Halo handheld starts global shipping in late July, top SKU hits $5,299
AYANEO is preparing global NEXT 2 shipments for late July after months of delays. The top Ryzen AI Max+ 395 configuration now reaches $5,299 as memory and storage costs continue to affect availability.
Karpa Health Launches Turnkey Nationwide Telehealth Platform as GLP-1, Peptide, and Hormone Demand Accelerates
The all-in-one platform helps entrepreneurs, clinics, med spas, gyms, and wellness brands launch cash-pay telehealth programs nationwide. TAMPA, FL / ACCESS Newswire / July 3, 2026 / Karpa Health today announced the general availability of its turnkey ...
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at Angel City FC
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's away match at Angel City FC
Global dietary estimates for conducting health, environmental and economic impact assessments
Nature Food - The Global Dietary Database for Impact Assessments provides information on what people eat across countries and demographic groups by integrating data on food availability,...
NotebookLM adding Short Video Overviews with Nano Banana 2 Lite
Google today announced Nano Banana 2 Lite and preview availability of Gemini Omni Flash, as well as NotebookLM Short Video Overviews.
University of Tennessee at Martin offers 4 day science camp for rising 6th to 8th graders
The University of Tennessee at Martin still has availability for their Meteorology and Agricultural Camp on June 29 through July 2.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Boring when people speak about my fitness
Reece James worked with Thomas Tuchel at Chelsea and is playing at his first World Cup as England's first-choice right-back. James has sustained a number of injuries in his career and has faced questions about his ability to play regularly with limited recovery time. "People always talk about injuries and availability, and to me it's so boring now," James told BC Radio 5 Live.
Yankees Mailbag: Mason Miller’s availability and Volpe’s struggles
The mailbag looks at the unlikely chance of landing an ace reliever.
State Choices, Unequal Access: Policies Shaping Reproductive Health Care Across the United States
Access to sexual and reproductive health care varies widely by geography, and state-level policies play a major role in establishing the contours that govern the coverage, provision, availability, and costs of services.
Sparks’ Rae Burrell stuns with daring pregame outfit vs. Wings
Rae Burrell confirmed her availability against the Dallas Wings with style, as the Los Angeles Sparks guard’s pregame outfit turned heads on Friday night. The 25-year-old arrived at Crypto.com Arena wearing a fitted black bodysuit with a black leather jacket.…
Dun & Bradstreet Brings Verified Business Data into Microsoft 365 Copilot
/PRNewswire/ -- Dun & Bradstreet today announced the availability of Graph Connector in Microsoft 365 Copilot, giving developers and enterprises no‑cost access...
Google’s Gemini Spark is ready to run your digital errands while your phone is off
You can now give Gemini Spark a task, turn off everything, and it still gets the job done.
Xbox games chief confirms Microsoft will show when its titles are coming to PS5 and other platforms at the Xbox Games Showcase — many fans aren't happy
Microsoft will broadcast multiplatform availability during the Xbox Games Showcase, frustrating fans.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Bay FC
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Bay FC
WHO Global Code of Practice on the International Recruitment of Health Personnel amended
WHO Member States adopted a resolution to amend the ‘WHO Global Code of Practice on the International Recruitment of Health Personnel’ (the Code) and strengthen its implementation, following Member State-led consultations in the lead up to the Seventy-ninth World Health Assembly. The resolution marks an important step towards the vision that everyone, everywhere can access competent and motivated health and care workers, as a foundation for both universal health coverage and global health security. Key additions to the Code focus on: inclusion of provisions on health personnel recruited internationally for employment as care workers; applicability of the Code recommendations during emergencies; and encouraging co-investment in health systems and health workforce to ensure international recruitment results in proportional benefits for source and destination countries.Since its adoption by the Sixty-third World Health Assembly in 2010, the Code has undergone three rounds of review of its relevance and effectiveness. “We welcome the resolution’s focus on sustainable and ethical mobility of health personnel,” explained Dr Yukiko Nakatani, WHO Assistant Director-General, Health Systems, Access and Data. “The Code’s adoption in 2010 was a landmark achievement. Following this update, we encourage all countries to enhance implementation, including by viewing co-investment as a win-win.” The additions were recommended by an Expert Advisory Group appointed by the WHO Director-General. The Expert Advisory Group’s final report noted the progress in health workforce data availability, provision of migrant health worker rights and the embedding of ethical recruitment principles in national policies. It also highlighted areas of possible improvement in the Code implementation, including support for the strengthening of health systems in source countries.The adoption of the resolution follows extensive consultations led by Member States, underscoring the continued relevance of the Code in a context of increasing international mobility of health workers and growing pressure on health systems resulting from global health emergencies and funding constraints.WHO is already taking forward actions called for in the resolution. An updated version of the ‘WHO health workforce support and safeguards list’, that guides ethical recruitment practices by identifying countries facing the most pressing health workforce challenges, will be published later in 2026. As recommended by the Expert Advisory Group, this will include additional flexibility enabling countries to indicate their willingness to allow active international recruitment, or for Member States not on the list to request tailored support and safeguards. This approach reflects a more nuanced, country-led framework that balances workforce mobility with the need to protect and strengthen health systems in vulnerable settings.“I thank the members of the Expert Advisory Group, the group of Member States who led the resolution, and all Member States for their constructive engagement,” added Dr Nakatani. “Let’s bring this spirit of collaboration to our collective efforts to implement the resolution, strengthen the health workforce and build resilient and equitable health systems.”
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