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UNMC awarded nearly $82.5 million in grants for research, public health programs

UNMC is getting nearly $82.5 million across about 151 grants and other funding allotments from the U.S. health department.

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Oct 21 • 5:01 PM EDT • Health • wowt.com
‘Klara and the Sun’ review: Film adaptation lacks novel’s poignancy

The film adaptation never quite finds the delicacy of Kazuo Ishiguro’s bestselling novel, writes Moira Macdonald.

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Oct 21 • 5:00 PM EDT • Entertainment • yakimaherald.com
US Embassy in Ottawa accuses Canada of election meddling

“Its ministers and premiers openly describe plans to influence American politics,” read a memo circulated by officials in Ottawa.

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Oct 21 • 4:52 PM EDT • Politics • politico.com
Ryan Flournoy Discusses Offensive Adjustments Ahead of Eagles Matchup
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Oct 21 • 4:09 PM EDT • Sports • sports.yahoo.com
Modern industrial building near interstate interchange offers flexibility for businesses

A modern industrial building with exceptional access to two major interstate highways offers a desirable location in northwest Sioux Falls with the ability to adapt for various business needs.

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Oct 21 • 3:25 PM EDT • Business • siouxfalls.business
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Your Voice, Your Vote: Stanley Langlow, Chelan County sheriff candidate

.engage-icon { width: 40px; height: 40px; margin: 5px; padding: 4px; border: 1px; border-style: solid; border-radius: 50%; cursor: pointer; } .icon-clicked { width: 40px; height: 40px; margin: 5px; padding: 4px; border: 1px; border-style: solid; border-radius: 50%; background-color: #C5D9E2; } .engage-container { display: block; margin-left: auto; margin-right: auto; padding: 10px; text-align: center; float: center; min-height: 100px; } .success-message { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; font-style: italic; color: #333; } .label { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; color: #000000; font-size: 14px; line-height: 1.42857143; } .link-button { border-radius: 5px; border-color: #333; background-color: #C5D9E2; color:#333; align:center; max-width: 175px; margin: 5px; } .button-text { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; color: #000000; font-size: 14px; line-height: 1.42857143; } Copy article link Sign up for our newsletters function Copy() { var button = document.createElement('input'), text = window.location.href+'/?utm_medium=internal&utm_source=readerShare&utm_campaign=bButton'; document.body.appendChild(button); button.value = text; button.select(); document.execCommand('copy'); document.body.removeChild(button); document.getElementById('articleShareButton').innerHTML = "Link copied!" }; Trending Wenatchee house fire displaces family, 3 dogs rescued 1 dead, another injured in car fire outside East Wenatchee Delilah: From local Wenatchee singer to Latin Grammy nominee East Wenatchee standoff ends after cigarette break Spokane developer applies for 250 apartment project outside East Wenatchee

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Oct 21 • 3:00 PM EDT • Politics • wenatcheeworld.com
Your Voice, Your Vote: Adam Musgrove, Douglas County sheriff candidate

.engage-icon { width: 40px; height: 40px; margin: 5px; padding: 4px; border: 1px; border-style: solid; border-radius: 50%; cursor: pointer; } .icon-clicked { width: 40px; height: 40px; margin: 5px; padding: 4px; border: 1px; border-style: solid; border-radius: 50%; background-color: #C5D9E2; } .engage-container { display: block; margin-left: auto; margin-right: auto; padding: 10px; text-align: center; float: center; min-height: 100px; } .success-message { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; font-style: italic; color: #333; } .label { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; color: #000000; font-size: 14px; line-height: 1.42857143; } .link-button { border-radius: 5px; border-color: #333; background-color: #C5D9E2; color:#333; align:center; max-width: 175px; margin: 5px; } .button-text { font-family: Helvetica Neue,'Open Sans',Helvetica,Arial,sans-serif; color: #000000; font-size: 14px; line-height: 1.42857143; } Copy article link Sign up for our newsletters function Copy() { var button = document.createElement('input'), text = window.location.href+'/?utm_medium=internal&utm_source=readerShare&utm_campaign=bButton'; document.body.appendChild(button); button.value = text; button.select(); document.execCommand('copy'); document.body.removeChild(button); document.getElementById('articleShareButton').innerHTML = "Link copied!" }; Trending Wenatchee house fire displaces family, 3 dogs rescued 1 dead, another injured in car fire outside East Wenatchee Delilah: From local Wenatchee singer to Latin Grammy nominee East Wenatchee standoff ends after cigarette break Spokane developer applies for 250 apartment project outside East Wenatchee

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Oct 21 • 3:00 PM EDT • Politics • wenatcheeworld.com
Prime Video’s ‘Fourth Wing’ series casts Esther McGregor and Emilio Sakraya as leads

Esther McGregor and Emilio Sakraya will play dragon riders Violet Sorrengail and Xaden Riorson in Prime Video’s adaptation of Rebecca Yarros’ best-selling novels.

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Oct 21 • 2:27 PM EDT • Entertainment • aboutamazon.com
Pocket Planet Canada Takes Immersive Entertainment to New Heights With Everest: The First Ascent

The Everest: The First Ascent VR experience opens at Pocket Planet Canada in downtown Toronto on November 10. ...

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Oct 21 • 1:59 PM EDT • Entertainment • globenewswire.com
Top Democrats join California immigrant, Nevada group to sue over federal election probes

The lawsuit accuses Trump and his administration of using “shoddily compiled lists of supposed noncitizens” and “coercive threats" against state officials to assert federal control over the midterms.

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Oct 21 • 1:18 PM EDT • Politics • latimes.com
Travis Kelce recalls early morning phone call from brother Jason that Taylor Swift called ‘f---ed up’

Everyone knows midnights are her afternoons, Jason!

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Oct 21 • 1:09 PM EDT • Entertainment • yahoo.com
Packers Coach Addresses Potential Offensive Line Change Involving Kevin Zeitler

Offensive coordinator Adam Stenavich said Tuesday that the Green Bay Packers will not change their offensive line “just to change,” with guard Kevin Zeitler closer to game shape and left guard Aaron Banks coming off what Stenavich called a good week of practice. Zeitler dressed for Sunday’s 23-13 win over the Dallas Cowboys so the [...]

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Oct 21 • 12:15 PM EDT • Sports • sports.yahoo.com
Reno + Sparks Chamber announces Latino Business Council launching in 2027

The Reno + Sparks Chamber of Commerce announced plans to establish a Latino Business Council on Jan. 4, 2027, to expand services, advocacy and networking opportunities for Latino business owners in Northern Nevada. The new council will work to increase chamber membership among Latino business owners and operators while developing programs that address their business […]

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Oct 21 • 12:01 PM EDT • Business • thisisreno.com
Week 7 Cincinnati Bengals Power Rankings Roundup

Though they didn’t play, they ended up in last place in the division.

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Oct 21 • 12:00 PM EDT • Sports • sports.yahoo.com
United Automobile, Aerospace & Agricultural Implement Workers of America

The labor union representing workers in auto, aircraft and agricultural implement manufacturing and other industries in the U.S., Canada and Puerto Rico.

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Oct 21 • 11:56 AM EDT • Politics • uaw.org
Set Your Calendar, T-Mobile Giving Out Free iPads For One Day Only

In an unusual move, T-Mobile appears to be giving out free iPad A16s for one day only next week, with qualifying service plan.

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Oct 21 • 11:53 AM EDT • Technology • tmo.report
Canada wants to expand its LNG business. Critics raise red flags

As Canada’s LNG exports grow, critics raise concerns over human rights abuses linked to major corporate investors.

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Oct 21 • 11:52 AM EDT • Business • aljazeera.com
Quinten Timber Reflects On Difficult Week With Crystal Palace

Quinten Timber has reflected on the two defeats to Lyon and Brighton, and has apologised to the fans for the display of the team.

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Oct 21 • 11:32 AM EDT • Sports • sports.yahoo.com
Steelers vs Saints: 4 big causes for concern this week

The Steelers and Saints square off in Paris this week and there are some serious concerns for this week's game.

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Oct 21 • 10:58 AM EDT • Sports • sports.yahoo.com
Packers Named Trade Fit for $22 Receiver at Deadline

The Green Bay Packers are thinner than they would like at wide receiver. Meanwhile, the Tampa Bay Buccaneers are sitting at 1-5 with Chris Godwin at wide receiver. It would make sense for the Packers and the Bucs to work out a potential trade, according to Matt Verderame of Sports Illustrated. Verderame notes that the […] The post Packers Named Trade Fit for $22 Receiver at Deadline appeared first on HEAVY.

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Oct 21 • 10:36 AM EDT • Sports • sports.yahoo.com
NEAR Rebounds After Launching A Business Wallet That’s ‘Confidential From The Market’, With XRP, Bitcoin And Solana Support

NEAR Business allowed teams to pay staff and vendors, swap assets, and allocate capital across more than 35 chains, including BTC, ETH, and SOL.

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Oct 21 • 10:01 AM EDT • Business • finance.yahoo.com
Three friends bring “Dr. Adams’ House of Terror” to Warrenton

Longtime Warren County friends Douglas Carter and Jason Jackson have been bringing spooky Halloween fun to the local community for the past two years, first with “Frightmare,” and last year,

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Oct 21 • 8:47 AM EDT • Entertainment • warrenrecord.com
Why Have Restaurants in Minnesota Gotten So Expensive?

Why have restaurants – in Minnesota and elsewhere – gotten so expensive? On this episode, we are joined by Adam Platt, Editor of Twin Cities Business, to break down the causes of why restaurants prices keep going up and what it means for the whole industry. Adam’s piece, “What’s With the $15 Side Salad?“, has

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Oct 21 • 8:12 AM EDT • Business • tcbmag.com
Astronauts’ hearts just passed a surprising test for Mars

A new study tracking 13 astronauts suggests that the human heart may be surprisingly well equipped for a journey to Mars, especially with regular exercise during spaceflight. Researchers found that astronauts' hearts adapted to months of weightlessness and handled simulated Martian gravity without major problems, offering new hope for future missions to the Red Planet.

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Oct 21 • 8:00 AM EDT • Science • sciencedaily.com
Cruz Foam had a promising idea. Why couldn’t it make its sustainable packaging business work?

Cruz Foam's biodegradable packing material made from shrimp shells and food waste attracted wide attention and big-name investors, but the Santa Cruz-based company has closed up shop after what one former exec says were struggles to solve the full range of problems its customers needed packaging to address.

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Oct 21 • 6:31 AM EDT • Business • lookout.co
This week in Santa Cruz County business: Cruz Foam ceases operations; West Coast Community Bank celebrates Nasdaq listing

Santa Cruz-based Cruz Foam, which developed a biodegradable packaging made from shrimp shells and other natural materials, has closed and sold off its intellectual property, Jessica M. Pasko reports in her weekly look at local business. Meanwhile, Santa Cruz-based West Coast Community Bancorp has moved its stock listing to the Nasdaq Stock Market, a milestone executives say is more than two decades in the making.

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Oct 21 • 6:29 AM EDT • Business • lookout.co
Colbie Young injury update more good news for Bengals

The Bengals start the week with some good injury news.

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Oct 21 • 5:31 AM EDT • Sports • sports.yahoo.com
Villegas, advocates slam Valadao voting record at Bakersfield health care roundtable

Healthcare affordability and reproductive rights took center stage at a roundtable in Bakersfield on Tuesday, as Democratic congressional candidate Randy Villeg

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Oct 21 • 1:21 AM EDT • Health • bakersfieldnow.com
💪 Chivas beat Necaxa and snap at América's heels

Chivas de Guadalajara earned a valuable 1-0 win over Necaxa on Matchday 13 of the Liga MX Apertura 2026 tournament, a result that lifts them into second place in the overall standings. An own goal bre...

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Oct 20 • 10:18 PM EDT • Sports • sports.yahoo.com
Lombardo check rejected as evidence during Fiore hearing

A Nevada judicial discipline panel rejected Gov. Joe Lombardo’s $5,000 check as evidence in proceedings against suspended Pahrump Justice of the Peace Michele Fiore.

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Oct 20 • 9:12 PM EDT • Politics • reviewjournal.com
Insider Reveals Michigan’s Starting QB vs. Indiana

Michigan is reportedly expected to start Tommy Carr over Bryce Underwood against Indiana after the freshman sparked a comeback win over Penn State.

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Oct 20 • 8:35 PM EDT • Sports • sports.yahoo.com
New Richland Lab Could Transform How Scientists Study Microbes and Boost Regional Jobs

The BriefGroundbreaking held Tuesday: PNNL officially began construction on the M2PC lab, a 30,800-square-foot facility funded by the U.S. Department of Energy's Office of Science that will study soil microbes to improve crop productivity and develop new biotechnology applications. The facility will be open to researchers from around the nation and the world.Research timelines could shrink dramatically: The facility's automation and AI capabilities could reduce experiments that currently take six months to just 72 hours, allowing scientists to explore more possibilities faster than ever before.New jobs coming to the Tri-Cities: The project is expected to create positions for automation engineers, AI experts, roboticists, technicians, and skilled craftspeople, with the facility opening in 2029.RICHLAND, Wash. — Pacific Northwest National Laboratory broke ground Tuesday on a first-of-its-kind facility that could accelerate scientific discoveries about the microscopic organisms living in soil—organisms that may hold the key to growing more food and developing new energy technologies.The Microbial Molecular Phenotyping Capability, or M2PC, represents a significant investment in automation and artificial intelligence to speed up research that traditionally takes years to complete. The 30,800-square-foot facility will house more than 100 connected automated instruments designed to study microbes at a pace and scale never before possible.Reshaping Agriculture's FutureThe M2PC facility will not put a new tool directly into a farmer's hands tomorrow morning, but it is actively reshaping the commercial pipeline to solve agriculture's biggest headache with biologicals: inconsistent field performance. For years, PNNL researchers have explored how microbes work and how they might help produce useful materials, advance energy technologies, and address challenges involving critical materials and minerals. But those experiments have been limited by what researchers could accomplish by hand."They can be used to provide nutrients to a plant so that the plant would grow more. So, like increasing your crop productivity, for example," said Douglas Mans, PNNL's Associate Laboratory Director for Integrated Discovery Sciences.PNNL's own research shows soil microbes can help plants access nutrients and withstand drought—benefits that could prove crucial as farmers face growing environmental pressures. The M2PC facility will allow scientists to identify and optimize useful microbes faster than ever before, accelerating the development of biological solutions that actually work consistently in the field.What Makes M2PC UniqueThe Microbial Molecular Phenotyping Capability differs from traditional research labs because it operates as a first-of-its-kind, AI-enabled autonomous laboratory designed to shrink experimental timelines from years down to months or weeks. The M2PC lab will connect more than 100 automated instruments to grow microbes, prepare samples, measure their behavior, and link observations to the molecular processes behind them. Artificial intelligence will help analyze results and guide the next experiments, allowing scientists to explore more questions faster.Deb Gracio, PNNL Director, emphasized the transformative potential during Tuesday's groundbreaking ceremony: "Research that has taken years will become possible in months and hopefully in weeks."That acceleration is already being demonstrated. PNNL's smaller automated lab, called the Anaerobic Microbial Phenotyping Platform or AMP2, completed three experimental cycles in just 72 hours—a process that normally would have taken about six months."That normally would have taken us about six months … and we were able to do that in 72 hours," Mans said.The AMP2 laboratory is not being closed or replaced. Instead, the current 1,800-square-foot laboratory serves as an active prototype and precursor for the much larger M2PC facility. AMP2 will continue operating as a separate lab designed to run anaerobic experiments—those conducted in the absence of oxygen—while M2PC will focus on aerobic research.Broader Applications Beyond AgricultureWhile improving crop productivity is one important application, the M2PC facility is designed to support research into multiple areas critical to national priorities. The lab will advance research into biofuels, manufacturing materials, and energy technologies. It will also help researchers understand how microbes respond to environmental changes and how to design biological systems for biotechnology applications.As a flagship component of the Department of Energy's Genesis Mission, M2PC represents a significant investment in using artificial intelligence and automation to accelerate U.S. scientific discovery. Dorothy Koch, Associate Director of the DOE Office of Science Biological and Environmental Research program, highlighted the facility's importance during the groundbreaking."M2PC will accelerate biological discovery and design," Koch said, noting that the facility is expected to conduct a minimum of 500 strain experiments per week, 100 microbiome experiments per week, and take a million measurements per month.Economic Opportunity for the RegionBeyond the scientific breakthroughs, the M2PC project represents significant economic opportunity for the Tri-Cities region. The facility will require hiring automation engineers, AI experts, technicians skilled in operating robotics, and specialized craftspeople to build and maintain the sophisticated equipment."We're anticipating that type of hiring," Mans said when asked about job creation.PNNL has already begun recruiting talent nationally and internationally for positions related to the smaller AMP2 lab, bringing automation engineers from cities like Boston and San Francisco to work in the region. The M2PC facility is expected to accelerate that trend."This capability won't really exist anywhere else in the world," Mans said, suggesting the facility could become a draw for scientific talent seeking to work on cutting-edge biotechnology research.Timeline and Next StepsThe M2PC facility is expected to open in 2029. Between now and then, construction crews will level and prepare the ground, while the building takes shape. Simultaneously, Ginkgo Bio Works, the automation contractor, will build the facility's automation components off-site so they can be installed as the building is completed.In the interim, PNNL researchers and the broader scientific community will begin planning the first experiments to be conducted in the facility, ensuring research is lined up and ready to begin as soon as the doors open.The groundbreaking ceremony included representatives from the Department of Energy, PNNL leadership, and elected officials at the federal, state, and local levels, underscoring the project's significance to the region and the nation's biotechnology future. News The U.S. Department of Energy Secretary tours Pacific Northwest National Laboratory Dan Hanson, Apple Valley News Now News Beyond DNA: Scientists Explore New Frontiers in Biology Research Dan Hanson, Apple Valley News Now News TRIDEC optimistic that Hanford, PNNL will see funding in national budget Robert Desaulniers News Big picture science: monitoring the Yakima River Basin News PNNL research could shape the future of fighting fentanyl ​COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.

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Oct 20 • 7:44 PM EDT • Science • applevalleynewsnow.com
AMC Entertainment Holdings (AMC) Shares Climbed, What Is Driving Attention Now?

AMC Entertainment Holdings (AMC) reported a strong Q2 earnings surprise, with revenue up 14.2% year on year and the stock climbing 48.7% since the report. AMC Entertainment Holdings has leaned into this momentum, with a 30-day share price return of 14.07% and a 90-day move of 36.89%, supported by the recent debt refinancing and the launch of its AMC Movie Trivia Game Show mobile app. The year-to-date share price return of 91.30% contrasts sharply with a 3-year total shareholder return that...

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Oct 20 • 7:14 PM EDT • Entertainment • finance.yahoo.com
Rams put Davante Adams, Poona Ford on IR
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Oct 20 • 6:29 PM EDT • Sports • sports.yahoo.com
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Alberta's decision to stay in Canada gives Carney backing to take on Trump

The overwhelming vote by Alberta to stay in Canada gives Mark Carney political capital to focus on remaking the country's economy, writes the BBC's Lyse Doucet.

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Oct 20 • 6:22 PM EDT • Politics • bbc.com
Nearby business bracing for impact after PepsiCo plant closure announced

Pepsi Co. is shutting down its South Knoxville bottling plant, laying off more than 100 workers.

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Oct 20 • 6:13 PM EDT • Business • wvlt.tv
Isaac Paredes offers the Yankees a better kind of contact

Eighty-eight strikeouts in 659 plate appearances caught my attention before the 25 home runs did. If the Yankees are going […]

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Oct 20 • 6:00 PM EDT • Sports • sports.yahoo.com
Packers OC Makes Feelings Clear on Josh Jacobs Return

Green Bay Packers OC Adam Stenavich didn't mince words when asked about RB Josh Jacobs' return. The post Packers OC Makes Feelings Clear on Josh Jacobs Return appeared first on HEAVY.

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Oct 20 • 5:12 PM EDT • Sports • sports.yahoo.com
Atlanta Hawks strike in-market streaming deal with Prime Video

As the Atlanta Hawks prepare to tip-off their season Wednesday against the Orlando Magic, the team has moved to create one of the more fan-friendly streaming arrangements in the entire league. The Hawks announced Tuesday that all local broadcasts will stream on Amazon Prime Video for fans within the team’s regional footprint at no extra…

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Oct 20 • 4:30 PM EDT • Sports • sports.yahoo.com
“Crystal Lake” showrunner complains about not showing nudity: ‘That’s America’

“You can give the kids the violence, but God forbid they see some breasts.”

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Oct 20 • 3:47 PM EDT • Entertainment • yahoo.com
Game Ready with Renown Health: Staying healthy during football season
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Oct 20 • 3:40 PM EDT • Health • nevadasportsnet.com
Tradition! DMTC returns to ‘Fiddler’

Davis Musical Theatre Company will present a special 60 min adaptation of the nine-time Tony Award-winning Broadway musical, “Fiddler on the Roof Sr.” The show follows Tevye the milkman as

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Oct 20 • 2:05 PM EDT • Entertainment • davisenterprise.com
Sundar Pichai: Google’s Frontier Imperative, Compute Scarcity Dilemmas, Future AI Products and Businesses

Alphabet CEO Sundar Pichai has little patience for doubts about Google’s willingness or capacity to compete at the frontier of AI. His company’s latest Gemini 4 Argon model — long-promised and recently delivered — beats OpenAI and Anthropic’s latest public models on coding, math, science, and knowledge-work benchmarks and has placed Google’s AI back among the world’s best. Amid chatter that Google was fine with good-enough lightweight ‘Flash’ models, Pichai pushed back hard against any suggestion that company is limiting its research ambitions. “We won’t do it any other way,” he told me in a Big Technology Podcast interview recorded this week at Google’s Mountain View headquarters. Pursuing cutting-edge research is costly for Google, requiring compute and chips that otherwise could be sold at a high markup by its cloud business. But Pichai said allocating resources to frontier AI development is “ground zero” for Google. “Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development,” Pichai told me. In our conversation, we discussed Argon (which Pichai says processed three times as many tokens as Gemini 3 in the 72 hours after launch), AI’s role in developing better models, the AI interface of the future, competition with OpenAI, Google’s partnerships with Anthropic and Apple, data centers in space, and the nature of his optimism. You can read the full conversation, lightly edited for length and clarity, below, or listen to it on Apple Podcasts, Spotify, YouTube, or your podcast app of choice. Alex Kantrowitz: Google is back at the frontier with Gemini 4 Argon, which beats OpenAI’s and Anthropic’s public models on benchmarks spanning coding, math, science, and knowledge work. The conventional wisdom was that Google had given up on the frontier to focus on fast, good-enough models for its products. That was wrong? Sundar Pichai: Very wrong. Look, we are so committed to being at the frontier. It’s in our DNA. We won’t do it any other way. We’ve been thinking about the AI frontier for well over a decade now. The frontier is very dynamic. It’s very competitive. It’s very exciting. I couldn’t be more pleased with how Argon has come together. We took our time with it. We made sure we tested it safely and deployed it carefully. We took a bit longer than our other models, given its capabilities. Across the board, be it for agentic work, knowledge work, coding, creative tasks, Argon is one of the really good frontier models. The first 72 hours since we launched, it’s almost up to 25 trillion tokens used, which is about three times what Gemini 3.0 had in the first 72 hours. And we are capacity constrained as we are serving it. Excited, but there are always areas….. You know, the frontier is very dynamic, and you have to keep evolving the models. There are areas which we can see we need to improve as well. We’ll be at work on all of that as well. Which areas? On any given model, Argon would be across the board better at everything if you just look even two months back. But the space is so evolving. Even on coding, for example, there are pockets where we know we need to do better, and there’s clear feedback. We’ll make it better. The argument for standard models is that they’re already good enough to build great products, with the frontier valuable only for certain tasks. Meta built Muse with good models rather than the best, and Google could put standard models into Maps, Gmail, and Search. Why isn’t that sufficient? It’s definitely not how I have thought about it at all. We are deeply committed to driving the state of the art and actually pushing where this technology can go, all the way from transformers. That’s a journey we’ve been on. You will see us continue to do that. When you’re at the frontier, you get an earlier look into the emerging capabilities, earlier than others, which helps you better prepare for the future. We are fortunate to have a wide set of opportunities across consumer and enterprise. Some of our cloud customers, for sure, want the model at the frontier. The frontier models will be better at developing the next set of models in an era of recursive self-improvement. I would argue it matters there. Internally, we have definitely seen a steep point of inflection by deploying Argon to our developers. It definitely tackles problems which our previous models could not do. Being at the frontier puts you at the innovation frontier and helps you drive that as well. There is room for models of all sizes and capabilities. That’s why we did Flash, Flash-Lite, etc. I agree with you that you can develop very good product experiences with not necessarily the most frontier model, because they tend to be slower and more expensive too. But we care about the Pareto frontier, and we’re committed to doing all of that. You said developing frontier models gives you a look at what’s coming. What do you see on the horizon? What makes this moment so exciting is you build something which you think is a culmination of months of work, and you put it out. You already see clear headroom ahead. We’ve all been working on these agentic, long-horizon capabilities, but clearly the frontier is going to have multiple of these agents working together to do things. That’s an example of an exciting paradigm underway. It’s also clear to me that users, both in consumer and enterprise, will have access to some multi-agent framework for them, working all the time doing things. It feels like a moment of infinite possibilities. Sergey Brin said one of Argon’s core innovations was relying more on the model to help develop the model. Yet incidents involving OpenAI’s bots breaking containment and Google’s bots accessing a site they shouldn’t have suggest these systems still aren’t perfectly aligned. Isn’t there reasonable cause for concern about accelerating toward recursive self-improvement? There are three parts to your question. Let’s first talk about RSI itself. You’re right, Sergey mentioned RSI being a critical contributor as we are developing Argon. But to be very clear, today, in a continuum, we are pretty far from the end state of RSI or something like that. The right way to describe it is you have RSI loops along with AI researchers in various aspects of model development. You almost have agents helping AI researchers in some automated way work together to build these models. It’s good to at least understand where we are today, and it’s super exciting. I expect that continuum to keep making progress as we go into next year. The second question is around safety. Security comes from defense in depth. You’re talking about alignment, obviously. We all are doing a lot of work to make sure the models are as aligned as possible. But it’s an active area of research, and there are clear gaps. That’s not the only thing we rely on. You have the work you do on alignment, but beyond that, we put a lot of effort into real-time monitoring as these models are working. Making sure you have good telemetry into what’s happening so that you can intervene in real time if you see unexpected behaviors. How you do that, the architecture with which you do that, how you make sure it’s all sandboxed and isolated in a way that it can continue doing its job during real-time monitoring — these are all areas of investment. Obviously, when we deploy these models, giving customers, enterprises, control, both with real-time monitoring, but their ability to decide where they deploy, what type of data which models ever have access to, etc. All that work is very, very important, and we are doing a lot of that. As an industry, we need to constantly up our game and take the time to do all this stuff, including dedicating the compute required to make sure you can safely deploy these models. The third part is: Is it all enough? This is why there are a lot of conversations in the industry, and I think it’s reasonable to be worried. The right way to approach something you worry about is early on thinking about what more we can do. As an industry, you’re definitely seeing increased levels of work on alignment, testing for safety, etc., as we deploy these models. The next step would be developing better standards so there are cross-industry standards of how we do these things, including the ability to evaluate using independent evaluators. If you look at areas like financial controls, we have accounting standards, we have independent auditors. Those are all the next natural steps for us as an industry to work toward, and regulation will end up playing a role as we go through all of that as well. Google pursues both language models and world models, while some other AI companies like OpenAI have focused more heavily on LLMs as the path to AGI. Why is world-model research important to you? As humans, you obviously perceive the world around you, and you’re taking all those inputs. Making sure these models are able to understand the laws of physics, simulate the world in high fidelity. All that, I think, are key enabling blocks for intelligence. We are working across all possible applications of this. Take an area like robotics. It’s not an accident: If you look at embodied reasoning benchmarks, Argon is state of the art. That all comes from our experience building world models. Inherently, I would expect there will be architectures which will converge all of this in the future. But for us, we view this as, today, this jagged frontier that is intelligence. We want to be at the frontier of all the possible approaches, and that will help us both drive better research, better insights, and develop a much better AGI model, is how we think about it. Some people argue Google should focus on selling its computing resources rather than using them for AI research. Cloud wants to sell compute at a high markup, while researchers need a very big computer to build the best models. How do you balance those demands? Ground zero for us is making sure we are investing in the compute that’s needed to be at the AI frontier. In 2015, I set the company to be AI-first. AI is that key horizontal ingredient across everything we do, all the way from Search to Cloud to Waymo. That is ground zero for us, making sure both for research and developing the models that we have enough compute needed. Beyond that, we have these independent businesses which each have their own long-range plans. They’re using those long-range plans to project forward, and we plan for compute for all of them. The cloud team, they have a business and they have a projection and they have demand signals. They have committed contracts. With that help, we can plan on a long-term compute trajectory for them. We’re fortunate to have this wide set of opportunities. There’s no company in the world which isn’t making trade-offs at any given moment in time. But the first principles we operate on is making sure we have enough compute to invest in the frontier, and that’s non-negotiable, and everything else works on top. Remember, we are building our own compute, our own data centers. There are long lead times. The compute we have today is a function of decisions I made in 2024. Even if you think back to a year from today, last year the agentic coding takeoff hadn’t happened. Today, obviously, when you sit and look at anything, everyone is short—not just us, other companies—and everyone wishes you had two times what you had planned for. That comes with the territory. At any given moment in time, we are planning for what we would need two to three years out in the future. You’re going to find some decisions you make may look suboptimal two years out, depending on where the state of the art is. I don’t spend too much time thinking about it. The way I think about compute allocation is making sure Google DeepMind, both for research and frontier model development, is cutting edge in terms of compute access. After that, we plan for all our businesses. It’s great we can provide our compute to other people too, like we have done. It allows us to scale that up, get real tests for it in the widest application set possible, test it in the real world, and make sure we are at the cutting edge of technology at every layer of our AI stack as well. Ben Horowitz relayed on a podcast that Andy Jassy had said compute was sold out until 2028. Are you seeing the same thing? If today a customer is coming out and asking us for compute in ’27, that is incredibly difficult to do. Even last year we went out and leased some short-term compute to accommodate some customers and help them out. But yes, we are all dealing with similar timelines. Every major technology shift seems to involve overbuilding, from railroads to fiber. Do you think that’s happening here? It depends on the time frames you’re looking at. This level of build, if I take a long enough time frame, it makes complete sense to me. We are at early stages of the most consequential technology ever, and this is not like fiber. It’s not dark. We are using it. We are capacity constrained on a daily basis. The applications, the underlying technology is improving rapidly. But running a company, the way I work through the moment is you look at your demand signals. You look at your committed revenue opportunities that you’re getting in the form of contracts. You balance that with the underlying technical capability, or internally you balance how we are using it internally, the model trajectories. Based on all that, you take a disciplined approach—a confident, aggressive, but disciplined approach—to plan out compute. But when you talk about the broader economy as a whole, you’re having people operate with various levels of risk. I focus on what I can control as a company and plan through it. If your question is, can there be an overbuild? Yes, because you can have some constrained components. Remember, what matters is a set of everything you need to build out that compute. Memory, electricity, electricians…. Land. Like 2,000 components or more. You could get constrained at some point. There could be things which cause bottlenecks, and then you could have overbuilds. There could be external shocks to the economy. There are macro risks. All that is possible at any given time. But am I confident that the compute we are planning for, we will have uses for it given enough time? Absolutely, yes. I was in the room when you said AI would be as profound as fire and electricity. If you believe that, shouldn’t you give researchers the biggest possible computer, even at the expense of today’s cloud profits? We’re all doing some form of that. Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development. What you’re seeing is true already. But you want to be thoughtful. Even our AI researchers have some constraints, which are also good. That’s what inspires creativity. That’s what helps you come up with a more efficient algorithmic breakthrough, maybe to use less memory. What we are committed to is to invest what’s needed to stay at the frontier. OpenAI President Greg Brockman told me a few months ago that the ideal AI product might have no interface at all—just as natural as conversation. What do you think the interface looks like in the age of AI? Computing historically has been humans adapting to computing. With AI, it’ll be the other way around. The technology will adapt seamlessly to how humans live and go about their day-to-day life. You want to be able to speak to that AI when you want to. It has context. It can be persistently running somewhere, give you continuity. You’re not dealing with a lot of complexity. It’s natural. All that makes sense to me. That doesn’t mean it won’t have any interface, however. Nowadays, even on my phone, Gemini voice models are so good. I can just press the microphone button. I can just ramble. That’s why we call it Rambler. I can ramble. It intelligently corrects with my personal context. Even my friends’ names, weird names, it gets it right, even if it first guesses it wrong. It’s amazing. I’m not going in, backspacing, editing once I finish saying it. It’s remarkable how good it’s gotten. But there are going to be moments you will need an interface. You may want to entertain yourself. You may want to watch a video. You may ask your AI to create something, and you want to watch it, consume it. The way I think about it is, you want it to be as seamless and as natural as possible, and that you are not doing the hard work adapting to whatever the interface is. The technology is adapting to how you’re working at any given moment in time. When I asked Sam Altman about competition from Google, he argued that OpenAI was building AI-native products and implied Google was bolting AI onto existing ones. Do you accept that framing, and can a “bolt-on” compete with an AI-native product? First of all, it’s a very dynamic moment. We are all pushing each other. OpenAI has pushed us as a company too. This is not just we are doing something to them. Far from it. Yes, Google went into its own version of a code red too. In the AI moment, all of us have to respond with varying levels of urgency at any given moment in time. We are constantly building new products as well. Gemini was built from the ground up as a product—the Gemini app I’m talking about. Or tomorrow, as all of us are adapting to agents, are you bolting agents onto ChatGPT, or are they building it natively? How would you think about that? You can always put these questions back. I don’t think of it that way. I think of it as you want to build world-class product experiences that are AI-native and they are winning. Some of it is adapting products, some of it is rethinking new experiences. They will all be part of how you approach this moment. How do you expect to make money from these AI interfaces? If an agent recommends a product and I buy it, should it take a cut of the sale, even if that’s disclosed? I’m going to put enterprise aside. Consumers are going to increasingly value this technology. Take software developers today. Developers are willing to pay for these coding models because it really helps make them more productive. Nobody would want to code the way they were coding three years ago, or even the same time last year. When you’re delivering value, there’s value to be had. I’ve never seen examples where consumer products really scale to billions of users, where people are using it intensely, and haven’t had monetization to go along with it. If you’re providing value to people, there is inherent value to be had. The nature of it may change. You’re asking a scenario in which agents are doing stuff for you. At the end of the day, you will have commercial needs. The agents need to fulfill those commercial needs. The providers on the other side are going to see value in that. There’s going to be some mechanism by which it gets fleshed out. That’s what an efficient system does. But what matters is that you’re building those world-class consumer experiences. I promised myself one product feature request: Can you make Gemini-powered search in Gmail as good as searching Gmail through ChatGPT? What’s going on here? One of the exciting things we announced recently is the unified Gemini agent for enterprise, and we’re bringing that to consumers. These are persistent agents which run 24/7 in the cloud. We’re spinning up a micro VM effectively for every query, and from the runtime, the harness, the model—it’s all a headless service. It’ll work everywhere, and it has your context with you. You can address this agent whether you’re in Workspace, in Search, in Gemini. Agents are going to drive this unification from a customer experience, which people are looking for. When you have a broad product portfolio and you’re moving forward fast, there are always areas where you’re moving forward faster than some other areas. That’s valid feedback. But we are putting a lot of time and effort into making sure, as we build out our agentic experience, that unification and that capability works well across all these services. People have asked where Google’s equivalent of Muse or Dots is. Do you anticipate creating a new product to compete with them? Our goal with Gemini is to be a personal, proactive, and powerful assistant. That’s what we are working toward. You saw us describe the early versions of it at Google I/O this year with Spark. Effectively, already, if you open the Gemini app as a Pro or an Ultra user, you see Chat and Task, and they start giving you that agentic experience. With Argon now, that capability is dramatically accelerated. What we announced recently in our enterprise event, we are bringing that to consumers as well. Soon in Gemini, you will be able to ask something, and it’s a continuum. You don’t need to think about whether you’re asking a chat or an agentic task. It’ll just automatically do the right thing, and it can work persistently in the background securely and get things done for you. Already, empirically, when I look at what’s coming into Gemini in our app, last year you would have tagged them and most of them would have been chats. But a steadily growing percentage is already agentic tasks in Gemini. Yes, we are going to bring personal agents to our consumers. It’ll work in the Gemini app. It’ll work in Google Search. It’ll work in Gmail. You can address it, call it, etc. We want to make sure we’re getting it right. It’ll be powered by Argon, and we are very excited to bring it to our users. Google has invested and committed tens of billions of dollars to Anthropic. What do you see in Dario Amodei that makes you want such a deep investment and partnership? Very early on, when we looked at the founding team of Anthropic, it was very clear to us this was a world-class team which was involved in some of the earliest GPT models. We were quickly able to assess that they would be at the frontier. We’ve always tried to identify and partner with companies which would be at the cutting edge of technology. We’ve done that with SpaceX. We’ve done that with Anthropic. That’s what we saw, and we had a chance to partner. Is your partnership with Apple to license Gemini for Siri expanding, contracting, or standing still? For both us and Apple, that partnership was about translating the capabilities of AI into better experiences for users. I thought Apple has done a phenomenal job of incorporating—they customize these models and build it into Siri—and it’s been great to see the reception. We are committed to doing more. You’re going to do more with them? There’s nothing specific to comment, but it’s a partnership. It’s working well. What have you learned so far about the feasibility of data centers in space? It’s a very exciting project. Projects like this remind me—I still recall that moment in the desert for the DARPA Grand Challenge, watching the Stanley car compete in it, which ended up being the basis for Waymo. With all these technologies, you’re at a moment in time where it looks a bit like sci-fi, but 10 to 20 years down the line, it’s actually working in a meaningful way. I feel the same in space. We’ve always believed in betting big on these technologies. Quantum has been a great example of it. We’re probably 10 years into the journey. Waymo, we are almost 20 years into the journey. Space, we are two to three years into the journey. It’s clear to me that it’s an approach which will make a lot of sense in the future. Being in sub-synchronous orbits with 24/7 access to the most abundant form of energy we have access to will make a lot of sense for this exponential increase in compute that we are going to need. Having said that, this is a challenging project. The team has disciplined milestones. It was a super exciting milestone to send the TPUs up to space. Sometime, as we are speaking, we are expecting a “hello world” moment from them. I look forward to seeing that happen, and we’ll continue investing here too. You previously said 25% of the code written within Google was written by AI. What’s the number today? That number in our world today is meaningless in the sense that every part of what we now touch is influenced by AI deeply. What we are tracking with Argon, for example, it’s been a point of inflection. People are using Argon to really go tackle complex projects, including projects which affect millions of lines of code. In the four weeks since we have launched Argon, we have seen a 30% increase in CLs, and more importantly, almost a similar increase—a one-third decrease in rollbacks. People are writing code more productively and better code with it. We are tracking it with newer metrics now. How are you dealing with opposition to data centers? If you can’t build in the U.S. the way you want to, where else do you go? We’re very committed to building our data centers very responsibly. When I look at our largest data centers in some of the communities where we have been the longest, I visit them, I talk to people. There are people who come and tell us their kids have gone to college because of our investments in these communities, and we’ve grown in those communities. To me, this is about doing it right. Engaging with the communities early, doing it transparently. We are committed to making sure we are bringing incremental power, and we cover 100% of the cost of our power needs for these projects. It’s understanding the impact on neighborhoods and making sure you’re working thoroughly to address them. Done rightly, you can continue making progress. But we are constantly taking feedback into account. I do worry not everyone operates the same way. People have been surprised by data centers showing up in their backyard. Those are all important. As an industry, we should continue to do better. But part of the reason, in a 20-year time frame, we are thinking about things like data centers in space is making sure we are able to put these data centers where maybe the trade-offs will be different. What unproven area of AI is Google working hardest to crack? Is it continual learning—getting models to keep updating after release—or something else? There are multiple parallel paths. You saw with Argon we have a million output tokens. With our Gemini models early on, we had a one-million context window on the input side. These are all examples of breakthroughs we are constantly working on. How do you think about synthetic data? How do you think about continual learning? How do you think about more efficient architectures? We do dedicate a meaningful percentage of our compute to these research bets too. It always goes hand in hand, including our world models. Those are all bets we are placing. Sometimes, as part of these bets, there are ideas that emerge which just make their way into the mainline models. Maybe we don’t fully talk about it, but we have multiple steps in these areas. Working in technology requires optimism that building something will improve the world, but those bets can leave real consequences when they fail. I recently returned to a town in El Salvador where enthusiasm for Bitcoin had given way to unfinished construction and something resembling a ghost town. How do you maintain the optimism you spoke about in your Stanford commencement address while accounting for those risks? I genuinely have a deep conviction that improving technology and improving access to technology makes people’s lives better. It’s been my personal experience in my life, out of which comes that deep conviction, optimism. But with that, I’ve always felt humanity’s journey is always about working hard to harness that technology to make it work well for society. The optimism is not an optimism that you just build whatever you want, whenever. You work hard to make sure you’re building technology in the service of humanity, to make the human condition better. That’s got to be the defining goal as we are approaching it. With that framework, I’m very, very optimistic. We are in very early stages of the kind of progress that we are going to see on many areas. We’re all talking about areas like healthcare. A lot of the progress is ahead. The ability to make things in a fundamentally cheaper way on many things where things have been getting expensive for a long, long time, discovering new materials, etc., which really bend the curve—it’s tough to step today and understand the impact of all that, but they’re going to be very profound. I’m very optimistic, but we have to be rightfully concerned about all the ways this technology can go wrong. Sundar, I know you don’t do many of these. Thank you. Thanks, Alex. Appreciate it.

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Oct 20 • 1:47 PM EDT • Technology • bigtechnology.com
Amazon hiring thousands in Southern Nevada

This year workers will receive a pay bump, with the company putting more than $1.5 billion into wage increases for its United States workers, Amazon said.

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Oct 20 • 1:30 PM EDT • Business • reviewjournal.com
Longtime Nevada Republican files complaint against GOP congressional candidate

The Federal Election Commission complaint against David Flippo cites reporting on his personal finances and campaign finance reports, and calls for an investigation.

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Oct 20 • 1:30 PM EDT • Politics • washingtonpost.com
Boys Town Nevada to honor Mark Davis at 35th anniversary gala for youth mental health

Boys Town Nevada 35th Gala Honors Mark Davis and Las Vegas youth mental health.

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Oct 20 • 1:23 PM EDT • Health • fox5vegas.com
Caitlin Clark joins Taylor Swift at Chiefs game

Caitlin Clark is making the most of her basketball offseason by returning to Arrowhead Stadium and cheering for her longtime favorite NFL team. The Indiana Fever star joined Taylor Swift as the Kansas City Chiefs defeated the Los Angeles Chargers, adding another memorable moment to Clark’s well-documented Chiefs fandom.

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Oct 20 • 1:00 PM EDT • Sports • sports.yahoo.com
Councilmember Mark Squilla is up for the PPA’s top job. Progressives are hoping to win his seat.

The potential of Squilla taking the job would shake up the race for his 1st District seat, and could give progressives an easier path to grow their ranks on Council.

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Oct 20 • 12:57 PM EDT • Politics • inquirer.com
Trump uses antisemitic slur to defend GOP Kansas senator

GOP Kansas Sen. Roger Marshall Marshall is locked in an unexpectedly tight reelection battle against Democrat Adam Hamilton in what might be the biggest surprise of the midterms.

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Oct 20 • 12:14 PM EDT • Politics • seattletimes.com
Ranking the Rockies, 2026: No. 39, Blake Adams

After uneven production in the farm system, Adams made his lone MLB appearance in August.

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Oct 20 • 12:00 PM EDT • Sports • sports.yahoo.com
First Clade I Mpox case reported in Clark County resident

The Southern Nevada Health District announced Tuesday the first confirmed case of Clade I Mpox in a Clark County resident.

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Oct 20 • 11:57 AM EDT • Health • fox5vegas.com
New on DVD: Behold the monstrous beauty of 'Frankenstein'

Guillermo del Toro's adaptation of Mary Shelley's classic novel tops the DVD releases for the week of Oct. 27. "Frankenstein": Released on Netflix last year, Oscar Isaac stars as mad

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Oct 20 • 11:56 AM EDT • Entertainment • recorderonline.com
Kyle Kennedy, RFK’s granddaughter and Kathie Lee Gifford’s step-granddaughter, dead at 42

Kyle Kennedy, the granddaughter of Robert F. ‘Bobby’ Kennedy and Ethel Kennedy, died last month, years after suffering a spinal cord injury.

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Oct 20 • 11:25 AM EDT • Entertainment • ew.com
Giants will release Najee Harris
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Oct 20 • 11:22 AM EDT • Sports • sports.yahoo.com
Griffin Gaming Partners launches new joint production company

A prominent game industry fund and Hollywood talent agency are teaming up to adapt games for TV and film.

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Oct 20 • 11:10 AM EDT • Entertainment • gamedeveloper.com
How Aday Mara's height, weight, wingspan compare to Victor Wembanyama

Aday Mara is being billed as the next Victor Wembanyama stopper, which has led to people comparing their physical traits.

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Oct 20 • 10:30 AM EDT • Sports • sports.yahoo.com
Paxton campaign showing ‘desperation’ with manufactured story: Political commentator

In the final days until election, President Trump is set to hold another rally in Texas for Republican Senate candidate Ken Paxton. MS NOW National Reporter Rosa Flores shares what she is hearing from voters there. MediasTouch Journalist Adam Mockler, Democratic Strategist Basil Smikle, Bloomberg Businessweek Journalist Max Chafkin, and Rolling Stone Magazine Politics Reporter Nikki McCann Ramirez join the Group Chat with Stephanie Ruhle to share their analysis.

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Oct 20 • 10:02 AM EDT • Politics • ms.now
Alberta rejects a move toward independence from Canada

With more than 1.5 million votes counted, 76% supported remaining in Canada

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Oct 20 • 9:12 AM EDT • Politics • spectrumlocalnews.com
T-shirts and silver balls: Politics get mixed in with the profane at a Trump store

By Elle Reeve, Samantha Guff, Frank Fenimore, CNN Boones Mill, Virginia (CNN) — Walk into Trump Town USA in Boones Mill, Virginia, and you may marvel at the breadth of human creativity, as long as you’re not distracted by how the merchandise tackles some of the most controversial political issues in the most vulgar way

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Oct 20 • 9:05 AM EDT • Politics • kvia.com
Griffin Gaming Partners and Entertainment 360 launch new company to support video game adaptations for film and TV

HITpoint Entertainment will "combine Griffin's relationships with devs and publishers with Entertainment 360's producing track record on IP-driven franchises"

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Oct 20 • 9:00 AM EDT • Entertainment • gamesindustry.biz
Chinese scientists find neurons may act as minicomputers to help decision-making

Researchers find evidence that suggests neural activity can guide the way the brain adapts to different sensory experiences.

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Oct 20 • 9:00 AM EDT • Science • scmp.com
Revisiting Brewers' Adames Trade Which Included Rays' Rasmussen

The Milwaukee Brewers transformed their infield with a midseason swap, but the Tampa Bay Rays struck gold by turning a struggling reliever into a dominant ace.

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Oct 20 • 8:53 AM EDT • Sports • sports.yahoo.com
Beyond Moneyball: What the Milwaukee Brewers Can Teach Businesses About Teamwork

The Milwaukee Brewers’ sweep of the defending champion Los Angeles Dodgers stunned the baseball world. But the series also showed that assembling the biggest collection of stars isn’t the only path to success, says University of Delaware researcher Kyle Emich. The Brewers' run to the World Series – which continues this week against the Tampa Bay Rays – demonstrates how a team can combine its strengths, adapt to an opponent and operate as a system, Emich says. That same p

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Oct 20 • 8:30 AM EDT • Business • newswise.com
Yankees news: Teruaki Sato will officially be posted

Sato will officially be posted this offseason; Boone returns as skipper for 2027; Wells identifies foul tips as potential cause of headaches.

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Oct 20 • 5:00 AM EDT • Sports • sports.yahoo.com
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain

Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)

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Oct 20 • 3:59 AM EDT • Business • fiercebiotech.com
Jacobe Smith Accepts Short Notice Fight for UFC Vegas 123

After a quick win earlier this month against Bruce Whitehead, Jacobe Smith already has his next fight booked. The undefeated welterweight takes on Randy Brown at UFC Vegas 123 in Las Vegas on October 31st. Brown was without an opponent after Carlos Leal pulled out due to an injury. Multiple sources have confirmed the fight […] The post Jacobe Smith Accepts Short Notice Fight for UFC Vegas 123 appeared first on HEAVY.

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Oct 20 • 1:34 AM EDT • Sports • sports.yahoo.com
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Science key to tackling worldwide challenges

Science and technology are immensely important for addressing shared global challenges and achieving the United Nations Sustainable Development Goals, especially in a world where geopolitical tensions are rising, said experts at a global forum in Beijing on Monday.

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Oct 19 • 11:37 PM EDT • Science • chinadailyhk.com
Grading every Padre on 40-man roster

Roster Review: Jason Adam

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Oct 19 • 11:05 PM EDT • Sports • sports.yahoo.com
Adam Levine recounts ‘really uncomfortable’ performance for rock legend on ‘The Voice’

Adam Levine recounts ‘really uncomfortable’ performance for rock legend on ‘The Voice.’ It happened 14 years ago.

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Oct 19 • 10:00 PM EDT • Entertainment • ew.com
Three Free Agent Relievers Who Could Fix Tigers’ Bullpen

The free agent relievers class is both strong and deep this off-season. That's great news for a Detroit Tigers team that struggled in high-leverage situations late in games, blowing 68 leads en route to a disappointing fourth-place finish in the American League Central. Those 68 blown leads are both a franchise and Major League Baseball …

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Oct 19 • 9:55 PM EDT • Sports • sports.yahoo.com
Former Las Vegas Councilwoman denies misusing donations during judicial discipline hearing

Michele Fiore testified that she believed a developer paid for a memorial statue honoring slain Metro officer Alyn Beck as she denied misusing donations during a Nevada judicial discipline hearing.

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Oct 19 • 9:22 PM EDT • Politics • reviewjournal.com
Syracuse Football: Halloween Game Time Finalized

The Orange host SMU on Oct. 31, marking the second consecutive home game on the holiday.

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Oct 19 • 6:46 PM EDT • Sports • sports.yahoo.com
10/19/26 – HAWAIʻI CLIMATE REBATE FINDER HELPS RESIDENTS AND LOCAL BUSINESSES SAVE ON UPGRADES

JOSH GREEN, M.D. GOVERNOR RYAN K.P. KANAKAʻOLE CHAIRPERSON HAWAIʻI CLIMATE REBATE FINDER HELPS RESIDENTS AND LOCAL BUSINESSES SAVE ON UPGRADES HONOLULU – Hawaiʻi households and local businesses now have a direct way to keep more money in their accounts and avoid missing out on valuable financial incentives. The Hawaiʻi State Climate Change Mitigation and Adaptation […]

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Oct 19 • 6:10 PM EDT • Business • dlnr.hawaii.gov
Seating supplier Lear names finance VP as its next CFO

Lear tapped a 23-year company veteran to serve as its next CFO

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Oct 19 • 5:18 PM EDT • Business • crainsdetroit.com
Former Raiders star will not face former team

Davante Adams out with hamstring rupture

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Oct 19 • 5:17 PM EDT • Sports • sports.yahoo.com
Jon Stewart to host “The Daily Show” on Comedy Central through 2028

The comedian-political commentator returned to the program in 2024, after his replacement, Trevor Noah, left to focus on his stand-up career.

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Oct 19 • 5:11 PM EDT • Entertainment • yahoo.com
Davante Adams injury update as Rams star suffers hamstring rupture

Rams wide receiver Davante Adams suffered a ruptured hamstring in the teams Week 6 game against the Cardinals. Here's how long he will be sidelined.

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Oct 19 • 5:04 PM EDT • Sports • sports.yahoo.com
Nevada DMV extending business hours during election period

The Nevada DMV says it will be expanding business hours and walk-in services during the election period.

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Oct 19 • 4:59 PM EDT • Business • fox5vegas.com
Nevada DMV extending business hours during election period

The Nevada DMV says it will be expanding business hours and walk-in services during the election period.

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Oct 19 • 4:59 PM EDT • Business • kolotv.com
‘Topdog/Underdog’ revival opens Steppenwolf's 51st season

When I reviewed the Chicago premiere of “Topdog/Underdog” at Steppenwolf Theater in 2003, I suggested that Suzan-Lori Parks' play about the rivalry between two Black brothers didn't deserve its 2002

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Oct 19 • 4:00 PM EDT • Entertainment • hpherald.com
Life in the deep Gulf plummeted after Deepwater Horizon

A new study has found populations of deep-water fish species, crustaceans and squid declined significantly following the 2010 Deepwater Horizon oil spill.

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Oct 19 • 12:50 PM EDT • Science • news.fiu.edu
Morning Download: Nevada-San Jose State football game to air live on NSN

On weekday mornings, Nevada Sports Net will recap three big headlines of the day in its Morning Download. Read below for today's topics.

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Oct 19 • 11:17 AM EDT • Sports • nevadasportsnet.com
Live Wire: Former Bishop’s Lounge to open with different name, familiar faces

The 41 Strong Ave. venue will reopen under the name Proof & Concept.

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Oct 19 • 10:54 AM EDT • Entertainment • masslive.com
Entertainment 360, Griffin Gaming: HITpoint Bridges Gaming, Hollywood

Bridging gaming and Hollywood, the new player will "source, develop, package, and produce adaptations" across genres, including action, horror, high-concept spectacle, comedy and beyond.

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Oct 19 • 10:00 AM EDT • Entertainment • hollywoodreporter.com
GM Says Apple Wallet Car Keys Coming to These Vehicles

In a late September press release that we just discovered now, GM announced that it has started rolling out Apple Wallet car key support in select Cadillac, Chevrolet, and GMC vehicle models, with additional models to follow over time. Google Wallet and Samsung Wallet will also be supported, with a related Samsung press release mentioning availability in the U.S. and Canada. GM said the rollout will occur as follows, with model years listed in parentheses.

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Oct 19 • 9:51 AM EDT • Technology • macrumors.com
Pierre Sage to remain Crystal Palace manager, but…

Despite being thrashed 5-0 by Brighton & Hove Albion at the weekend, Pierre Sage is nevertheless expected to be given more time to prove himself as Crystal Palace manager, according to reports in The ...

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Oct 19 • 9:01 AM EDT • Sports • sports.yahoo.com
VOTE: What is your biggest fall health question?

News4 NBC Reno covers news, sports, weather and traffic for the Reno, Nevada area including Sparks, Carson City, Virginia City, Silver City, Stagecoach, Silver Springs, Sun Valley, Cold Springs, Spanish Springs and Fenley, Nevada and Truckee and Tahoe City, California.

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Oct 19 • 8:57 AM EDT • Health • mynews4.com
Amer Sports announces Atomic leadership change

Michael Absmaier has been appointed President Atomic and Armada and member of the Amer Sports Global Leadership Team, effective January 1, 2027.

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Oct 19 • 8:30 AM EDT • Sports • amersports.com
Dodgers' Call Expected to be Non-Tendered

Once a postseason standout, this Los Angeles Dodgers outfielder now faces a roster squeeze.

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Oct 19 • 8:00 AM EDT • Sports • sports.yahoo.com
Professional golfer from Finland moves business to Fairview

A golf professional who hails from Finland and moved his business to Fairview approaches teaching the sport differently. For Jari Hakonen, it is all about focusing on the little things […]

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Oct 19 • 8:00 AM EDT • Business • estacadanews.com
RCPS seeks funds to expand science labs, STEAM education

CONYERS — Rockdale County Public Schools could receive up to $1 million to expand elementary science labs and arts education through a state tax credit initiative, as district officials work

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Oct 19 • 6:16 AM EDT • Science • rockdalecitizen.com
Meet the researchers leaving the US because of Trump's funding cuts and politicization of science

Many American scientists are being recruited by foreign universities holding out offers of stable funding and academic freedom. It began last year after the Trump administration began making seismic changes

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Oct 19 • 6:04 AM EDT • Science • guardonline.com
Mass. nail salon workers face low pay, health hazards

A survey of Massachusetts nail technicians found that most earn less than $40,000 and suffer from headaches, asthma, and nausea.

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Oct 19 • 6:01 AM EDT • Health • bostonglobe.com
Trump to head to Kansas to show support for embattled Marshall

Incumbent Republican senator is facing strong challenge from Democrat Adam Hamilton in state that has been red for almost a century

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Oct 19 • 5:39 AM EDT • Politics • theguardian.com
😐 Neutral (10%)
wow
60%
ahah
40%
Yankees news: Bombers showed past interest in Padres’ reliever

Yankees eyed Jeremiah Estrada in the past; third base remains a problem; which free agents are likely to return?

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Oct 19 • 5:00 AM EDT • Sports • sports.yahoo.com
IOPP and China Science Publishing & Media announce partnership

Collaboration will make IOP Publishing's journal metadata available through SciEngine, improving research discoverability in China

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Oct 19 • 4:17 AM EDT • Science • researchinformation.info
“A valid entertainment” – Things We Lost in the Fire by Mariana Enriquez (adapted by Lucas Nine)

What we have here is a graphic version of about a quarter of Mariana Enriquez’ debut short story collection, Things We Lost in the Fire. If you have even a cursory knowledge of Enriquez (via Things…

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Oct 19 • 4:00 AM EDT • Entertainment • bookmunch.wordpress.com
Lamine Yamal and Kylian Mbappe on form ahead of El Clasico, Bayern Munich top and Lazio march on in Euro Debrief

Lamine Yamal, Kylian Mbappe and Harry Kane were all on target again but Lazio are the talk of Europe. Adam Bate picks out the big stories from the continent in the Euro Debrief, a Sky Sports column focusing on the major European leagues and more...

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Oct 19 • 3:41 AM EDT • Sports • skysports.com
‘The little thieves and the bigger thieves’

During the 1950s, on one wall of each classroom at Holy Rosary Elementary School in Idaho Falls a huge pre-World War II map was posted. All the British Commonwealth holdings appeared in pink and seemed to cover nearly half the globe. Their Mercator projection made Canada appear immense, as well as Alaska. Tucked into Central […]

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Oct 19 • 3:00 AM EDT • Politics • coloradopolitics.com
SCAI UCO | Virtual tour generated by Visitas Virtuales Granada

Virtual tour generated by Visitas Virtuales Granada

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Oct 19 • 12:33 AM EDT • Entertainment • uco.es