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Elanco CEO: One Health district will create statewide impact
The CEO of Indianapolis-based Elanco Animal Health Inc. said the growing One Health Innovation District in downtown Indy is representative of a movement throughout the state.
Medicaid cuts put 60,000 New York immigrants’ coverage at risk
Refugees, humanitarian parolees and survivors of abuse are among those affected by an Oct. 1 loss of federal health coverage, while the long-term future for coverage remains unclear.
LABJ Stock Index: October 12
AI Tools and Your Privacy: What You Need to Know Easy-to-use artificial intelligence tools may soon change our work and school lives – but they come with
BiomEdit receives conditional licensure for first commercial product
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World Food Championship returns this week
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Mammoth Solar projects begin commercial operation in northwest Indiana
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Assemblymember Maggy Krell on new sex abuse law impacting college campuses amid Cornell case
Assemblymember Maggy Krell, a former sex crimes prosecutor for the California Department of Justice, spoke about the alleged sexual assault at Cornell University, calling it a "moment of reckoning" and emphasizing the need for stronger enforcement and prevention measures.
Erie County Health Department reports case of diphtheria in local school district
Diphtheria cases are extremely rare but officials in the West Seneca Central School District are acting “out of abundance of caution” to alert families.
Elanco, Purdue planning research institute at One Health Innovation District
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var audio_insight_data = { event_type: "video_played", data: { video_id: post_id, video_url: post_url }, ...insight_data, }; insight.track(audio_insight_data); } if (video.started && video.paused) { video.resumed = true; window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Resumed", eventLabel: event_label }); var audio_insight_data = { event_type: "video_resumed", data: { video_id: post_id, video_url: post_url }, ...insight_data, }; insight.track(audio_insight_data); } }); player.on('pause', function() { if (vast.ended) { video.paused = true; window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Paused", eventLabel: event_label }); var audio_insight_data = { event_type: "video_paused", data: { video_id: post_id, video_url: post_url }, ...insight_data, }; insight.track(audio_insight_data); } }); player.on('ended', function() { //vast.adEnd fires after ended, pointless to use. vast.ended = true; if (video.started && !video.ended) { video.ended = true; window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Ended", eventLabel: event_label }); } var audio_insight_data = { event_type: "video_completed", data: { video_id: post_id, video_url: post_url, percentage: 100, }, ...insight_data, }; insight.track(audio_insight_data); }); player.on('fullscreenchange', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Fullscreen Toggled", eventLabel: event_label }); }); player.on('enterpictureinpicture', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Picture-in-Picture Opened", eventLabel: event_label }); }); player.on('leavepictureinpicture', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Picture-in-Picture Closed", eventLabel: event_label }); }); let lastReportedPercentage = 0; player.on('timeupdate', function() { const currentTime = player.currentTime(); const duration = player.duration(); if (duration) { const progressPercentage = Math.floor((currentTime / duration) * 100); if (progressPercentage % 5 === 0 && progressPercentage !== lastReportedPercentage) { lastReportedPercentage = progressPercentage; var audio_insight_data = { event_type: "video_completed", data: { video_id: post_id, video_url: post_url, percentage: progressPercentage, }, ...insight_data, }; insight.track(audio_insight_data); } } }); .video-js, .video-js .vjs-tech { position: relative; width: 100%; height: auto; z-index: 0; } var player = videojs('player_block_3e0dd12dd9e4b24938fb711c6167c088'); player.nuevo({ contextMenu: false }); var vast = { started: false, paused: false, resumed: false, ended: false, }; var video = { started: false, paused: false, resumed: false, ended: false, } var event_label = 'Video: 0 - Article: Elanco, Purdue planning research institute at One Health Innovation District'; var post_id = 209492; var post_url = "https://www.insideindianabusiness.com/videos/elanco-purdue-planning-research-institute-at-one-health-innovation-district-2"; 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window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Paused", eventLabel: event_label }); var audio_insight_data = { event_type: "video_paused", data: { video_id: post_id, video_url: post_url }, ...insight_data, }; insight.track(audio_insight_data); } }); player.on('ended', function() { //vast.adEnd fires after ended, pointless to use. vast.ended = true; if (video.started && !video.ended) { video.ended = true; window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Ended", eventLabel: event_label }); } var audio_insight_data = { event_type: "video_completed", data: { video_id: post_id, video_url: post_url, percentage: 100, }, ...insight_data, }; insight.track(audio_insight_data); }); player.on('fullscreenchange', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Fullscreen Toggled", eventLabel: event_label }); }); player.on('enterpictureinpicture', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Picture-in-Picture Opened", eventLabel: event_label }); }); player.on('leavepictureinpicture', function() { window.dataLayer.push({ event: "Videos", eventCategory: 'Video', eventAction: "Video Picture-in-Picture Closed", eventLabel: event_label }); }); let lastReportedPercentage = 0; player.on('timeupdate', function() { const currentTime = player.currentTime(); const duration = player.duration(); if (duration) { const progressPercentage = Math.floor((currentTime / duration) * 100); if (progressPercentage % 5 === 0 && progressPercentage !== lastReportedPercentage) { lastReportedPercentage = progressPercentage; var audio_insight_data = { event_type: "video_completed", data: { video_id: post_id, video_url: post_url, percentage: progressPercentage, }, ...insight_data, }; insight.track(audio_insight_data); } } });
FULL SHOW: Inside INdiana Business 10/11/26
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Padres Catching Shift Could Clear A Path For A Trade
The San Diego Padres made some changes in their catching situation, and they now have an abundance of riches there.
Former NC State Sports Medicine Director faces Wake County Judge in sexual abuse case
Former NC State Sports Medicine Director Robert Murphy appeared in Wake County court Friday on 32 charges related to sexual abuse allegations involving former student-athletes.
Boston Celtics: One Thing Abundantly Clear After Preseason Opener
If there were any doubts about how the Celtics were going to play in 2026-27, you can erase them now.
SAIC acquires quantum encryption firm
Reston-based federal contractor Science Applications International Corp. has acquired quantum encryption firm Information Security Corp. for an undisclosed amount.
Hourigan promotes new construction, Central Virginia leaders
Richmond-based Hourigan promotes Michael Henley to president of construction and Mark Hourigan Jr. to vice president of Central Virginia unit.
Virginia furniture retailer Haynes and The Dump to close
Virginia Beach-headquartered top 100 furniture retailer Haynes Furniture and The Dump will close permanently. Virginia Beach-headquartered top 100 furniture retailer Haynes Furniture and The Dump will close permanently.
Letters: Retain Muñiz | Nixon will protect abuse survivors
Justice Muñiz keeps an open mind, listens to every party, and treats people with professionalism and kindness.
Former NC State sports medicine director back in North Carolina to face sexual abuse charges
U.S. Lawmakers Launch Sexual Abuse Probe of Youth Sports Giant AAU
Bipartisan leadership of a powerful House committee demanded answers from the Amateur Athletic Union after a ProPublica and Washington Post investigation found that the massive youth sports organization has failed to protect kids from sexual abuse.
Fundamental Brings Nexus to LA Galaxy and L.A. Live Through New Official Partnership with AEG
Fundamental's NEXUS model joins two of Southern California's most iconic sports and entertainment properties, bringing predictive technology to the business of sports and live entertainment LOS ANGELES, Oct. 8, 2026 -- Fundamental, an AI company whose Large Tabular Model (“LTM”), NEXUS is reimagining enterprise decision-making, and AEG, the world’s leading
US suspends visa program for tech firms including Microsoft
The Trump administration said it would suspend an immigration program for multiple tech firms, including Microsoft Corp., alleging widespread abuse of a worker visa system. “There has been no company
FinnBoy Records, Books & Curio offers curated vintage experience
FinnBoy Records, Books and Curio sits to the west of GU's campus, offering a wide variety of physical media and vintage finds.
“Big Cat Diaries”: A story about accompaniment and connection
Last week, the Magnuson Theatre hosted their performance of "Big Cat Dairies" inspired by a GU professor's experience in the Amazon rainforest.
Halle Berry’s daughter defends mom amid ex Olivier Martinez’s child abuse claims
Halle Berry’s 18-year-old daughter is defending her mom against the Oscar winner’s ex-husband Olivier Martinez, who claims Berry physically abused their 13-year-old son.
ICF International to lay off 82 employees
ICF International plans to begin laying off 82 employees in December after the Department of Homeland Security decided to consolidate work.
The Math Singularity Is Here, and Science May Be Next
OpenAI has released an extraordinary body of mathematical work produced by an unreleased frontier model: 722 manuscripts spanning 372 research families across fields including number theory, complexity theory, and mathematical physics. Each result required, on average, the equivalent of roughly three hours of ChatGPT Pro reasoning. A New Era of Discovery We may be witnessing the beginnings of a “math singularity”: a point at which machine-generated discovery accelerates beyond humanity’s ability to independently reproduce, verify, or fully absorb it. If frontier models can generate hundreds of meaningful results in the time it takes a human researcher to investigate one, the constraint will no longer be producing new mathematics. It will be our capacity to validate, interpret, and integrate it. This does not make mathematicians obsolete. It changes their role. They may increasingly serve as guides, critics, and meaning-makers. Increasingly, they will decide which questions matter, determining which results can be trusted, and explaining why they are important. Mathematical insight may become abundant, while human judgment becomes more valuable than ever. Mathematics May Be Only the Beginning Every scientific discipline could eventually experience a similar acceleration. AI systems could generate and test hypotheses, connect findings across specialized fields, and explore possibilities at a scale no human research community could match. In medicine, imagine models identifying overlooked disease mechanisms, designing drugs and clinical trials, personalizing treatments, or discovering cures in months rather than decades. In materials science, AI could help create better batteries and cleaner industrial processes. In climate science, it could accelerate advances in energy, forecasting, and carbon removal. In biology, it could uncover relationships hidden across enormous genomic and molecular datasets. The result would not simply be faster research. It could expand the frontier of what is scientifically possible. The New Bottleneck Scientific discovery, however, is not the same as scientific progress. A medical breakthrough must still survive laboratory testing, clinical trials, regulatory scrutiny, manufacturing constraints, and real-world deployment. As machine-generated ideas multiply, the bottleneck may shift from producing breakthroughs to validating them safely and translating them into practice. We may soon have more hypotheses than laboratories can test, more drugs than clinical trials can evaluate, and more mathematical results than experts can review. That imbalance will require better systems for automated verification, reproducible research, prioritization, peer review, and collaboration between AI and domain experts. The importance of OpenAI’s work is not merely the number of manuscripts produced. It offers a glimpse of a world in which intelligence can explore thousands of intellectual paths in parallel. If ideas cease to be scarce, humanity’s defining challenge will be deciding which are true, which matter, and how to turn them into progress. The math singularity is not the end of human inquiry. It is the beginning of a new kind—one in which machines expand the frontier of knowledge and humans decide where it should lead. Subscribe Share Leave a comment
General Dynamics names next CEO, as Novakovic becomes exec chairman
Phebe Novakovic, General Dynamics' longtime CEO, will transition to executive chairman on Jan. 1, 2027, as President Danny Deep becomes the Fortune 500 aerospace and defense contractor's next leader, the Reston-based company announced Wednesday.
Virginia’s two biggest craft beer brewers to merge
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HHHunt names next CEO
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Mamdani wants to let New Yorkers sue over unfair business practices, but some biz groups aren’t sold
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Department of Health and Human Services audit states ‘Arkansas failed to comply’ with requirements for reports of child abuse
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Abundantia Entertainment To Turn AI Arm AiOn Into Standalone Studio
cription (150 character max) India's Abundantia Entertainment is moving to turn its AI creative arm Abundantia AiOn into a standalone production studio.
Former CIA official accused of stealing $40M in gold bars pleads guilty
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Sentara ends negotiations with Anthem on health plans
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Sentara ends negotiations with Anthem on health plans
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Virginia ranked No. 1 for workforce training
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Halle Berry denies ex-husband’s claim that she abused their 13-year-old son: ‘I would never hurt our child’
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2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
Dennis Hastert, Powerful Politician Disgraced by Child Sexual Abuse, Dies
The longest-serving Republican speaker of the House admitted in 2016 to abusing teenage boys decades earlier. He was 84.
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Democrats release midterms ad featuring family of Epstein victim Virginia Giuffre
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Delta Health Center Receives Funding
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Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
The Business of Civility
In an ever-coarsening world where even hosts on the bastion of conservative media, Fox News, are now using profanity on a regular basis, there is still one place where civility is demanded—and usually delivered. And that place is the business community. Whether you’re ordering a meal at McDonald’s or interviewing the wealthy CEO of Mississippi’s […]
After success in Ascension with steel plant, Iberville Parish proposes its own industrial zone
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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Study: IL lawyers report mental health challenges, substance abuse, suicide ideation
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In Tabuk, humanity and compassion came before politics
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Olivier Martinez granted temporary restraining order against Halle Berry after accusing her of abusing their son
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Key late-2026 economic indicators for Nevada, Clark County and Washoe County, including employment gains, taxable sales growth and gaming revenue trends.
Lee Health Foundation Welcomes Kim Snarr as Director of Grants
Lee Health Foundation has welcomed Kim Snarr as director of grants, bringing nearly a decade of experience in grant strategy, revenue growth, compliance management, and cross-functional leadership within the nonprofit sector. Snarr joins Lee Health Foundation from the Center for Prevention of Abuse where she served as director of grants administration. Prior to her leadership […]
The Dream Awards to Honor Entertainment, Media Legends in Las Vegas, Sunday, Oct. 25
LAS VEGAS (September 2026) – On Sunday, Oct. 25, entertainment and media legends will gather at The Orleans Hotel & Casino in Las Vegas for the 2026 Dream Awards. The red-carpet program will honor a
Private equity firm buys Chesterfield industrial campus for $108M
A Boston real estate private equity firm bought a five-building industrial campus in Chesterfield County for $108 million.
S&P 500 dips, Nasdaq higher on modest rise in inflation
NEW YORK, Sept 30 (Reuters) - Nasdaq climbed on Wednesday and the S&P 500 dipped, with both indexes notching their second straight quarterly gains, as