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Fourteen foodborne parasites still drive 171 million illnesses worldwide, analysis finds
Recent Cyclospora outbreaks have renewed public attention to foodborne parasites, but they also highlight a broader reality: These diseases continue to affect millions of people around the world and remain ...
Age slower without dieting: this cultural habit stuns scientists worldwide - Futura-Sciences
Savoring Culture: A Surprising Health Ally Picture this: according to a British study involving more than 3,500 adults, a weekly dose of culture—be it through visiting museums, browsing in a library, humming along in a choir, or wielding a paintbrush—was linked to knocking one year off participants’ biological age, and...
Former Washington Football WR Gets Chance With Kansas City Chiefs
Former Washington Huskies wide receiver Omari Evans continues to make a case for himself sticking with the Kansas City Chiefs.
Maker of ice cream sold at grocery stores nationwide files for bankruptcy as it appeals $23.8M judgment
Rebel Creamery reported $13.78 million in assets and $23.85 million in liabilities as it appeals a $23.785 million Van Leeuwen judgment.
Major political transformation is underway in Hungary after Victor Orban was ousted
NPR's Danielle Kurtzleben speaks with journalist Nick Thorpe about the changes made by the Hungarian government since Victor Orban's Fidesz party lost power following elections in April.
Politics chat: Democrats take lessons from the primaries, set 2028 calendar
We look at how the Democrats are gearing up for the 2028 presidential primaries, as well as their takeaways from the current batch of primary races.
Pork and politics: Canadians bring trade pitch to Iowa state fair
DES MOINES — Pork is a popular topic at the Iowa State Fair as hungry patrons mow down on barbecue and curious children gaze with wide eyes at the state's biggest pig.
Inside America's health insurance 'death spiral'
The Affordable Care Act is facing what policy experts call its most serious affordability crisis since it began widely offering coverage more than a decade ago
Post-game live reaction: Seahawks vs Cowboys Preseason Game 1
The Seattle Seahawks marched down the field with Drew Lock at the helm, aided by two big penalties on the Dallas Cowboys, before punching it in for a 7-0 to kick off the game. After taking more than seven minutes off the clock, wide receiver Montorie Foster Jr. scored the first touchdown of the preseason […]
Biggest Overreaction USC Trojans Fans Should Avoid
The USC Trojans wide receiver room will look different in 2026, but here's why fans shouldn't overreact.
Chargers Offensive Line Looked Formidable in First Preseason Game
The Chargers’ offensive line made a strong first impression in the preseason opener against the Texans. With the left guard competition still wide open, several players stepped up and showed why this group could be better than expected in 2026.
With measles cases on the rise, doctors stress childhood vaccination
As nationwide measles cases climb to the highest levels seen in 35 years, Lucas County medical practitioners are raising the importance of vaccinating ...
Browns rookie wideout impresses in preseason loss to Bears
A rookie stood out for the Cleveland Browns in their 2026 preseason opener against the Chicago Bears.
Armenian Genocide survivors' grandson says 'political motives' block recognition
In 1915, the Ottoman Empire began the systematic deportation and massacre of its Armenian population. As many as 1.5 million Armenians were killed – widely regarded by historians as the twentieth century's…
Commanders' unofficial depth chart reveals questions at wide receiver
The Washington Commanders unofficial depth chart reveals continued uncertainty in the wide receiver room.
Health insurance rates expected to climb again for Minnesotans in 2027
Thousands of Minnesotans could see higher health insurance costs next year as insurers seek rate increases across individual and small-group markets.
UVA Health Blue Ridge Poison Center reports nationwide increase in liver injuries from medication
Researchers are concerned about youth suicide attempts and older person pain relief overdoses.
Helaine Cohen
With a background in marketing and technology, Helaine Cohen founded ChicagoCondoFinder.com, a website for people searching for condos in Chicago. Last year, the site had 290,000 visitors who drove more than $40 million in buyer business. In 2018, Cohen announced a partnership to expand the brand and team with real estate veteran Sam Tarara. As a broker, Cohen represents sellers in a wide range of prices, but her expertise is primarily in the luxury condo market.
I don’t think the foldable iPhone stands a chance against the Galaxy Z Fold 8
Apple appears so mired in problems that getting ahead of Samsung feels impossible.
Vikings HC Kevin O’Connell Has Strong Justin Jefferson Message
Justin Jefferson still reached the 1,000-yard mark last season, but it was anything but a smooth year for the Minnesota Vikings star. The inconsistent play at quarterback took a toll on Jefferson’s production, leading some to rule him out as the best wideout in the NFL.During the 2025 campaign, Jefferson played 392 pass snaps for […] The post Vikings HC Kevin O’Connell Has Strong Justin Jefferson Message appeared first on HEAVY.
Six Flags Entertainment (FUN) Following Wider Losses Is The Fair Value Case Still Intact
Six Flags Entertainment (FUN) has drawn fresh attention after reporting second quarter 2026 results that showed lower revenue and larger net losses compared with the same period a year earlier. See our latest analysis for Six Flags Entertainment. Following the results, Six Flags Entertainment’s share price has moved to $16.68, with a 1-day share price return of 1.46% and a 7-day share price return of 5.90%. However, the 90-day share price return is down 21.76% and the 1-year total shareholder...
Survey: Healthcare costs potent political issue in Georgia, but more for Democrats than Republicans
As Georgia approaches its gubernatorial election, candidates Keisha Lance Bottoms and Rick Jackson offer opposing solutions to rising healthcare costs amid a University of Georgia survey showing widespread bipartisan concern over affordability and price transparency.
Gallery: Baptist Health Walker opens pediatric ER space, reopens NICU services
Baptist Health Walker Hospital has opened a new dedicated pediatric emergency room treatment space and reopened its Level II NICU services.Hospital leaders cut
Collins vows to push for ICE reforms
In recent weeks, Democrats and Democrat-aligned groups have been critical of Collins, a Republican running for her sixth term, for supporting increased funding for Immigration and Customs Enforcement.
Health policy must be driven by data, not political grandstanding
'The administration’s anti-vaccine rhetoric will only sow widespread confusion, ultimately driving up rates of entirely preventable childhood diseases,' writes an L.A. Times reader.
World Humanitarian Day 2026: honouring fallen humanitarians and calling for greater protection of health care
As we mark World Humanitarian Day on 19 August, WHO pays tribute to humanitarian and health workers who put their duty of care above their own safety and, too often, their own lives as they serve communities affected by conflict and crises.World Humanitarian Day was designated by the UN General Assembly in 2008 to commemorate the 2003 bombing of the UN headquarters in Baghdad and honour aid workers worldwide.
Predicting which WRs make Cowboys 53-man roster
Which wide receivers do you think are going to make the 53-man roster?
IRC launches health, child protection response as Colombia earthquake death toll rises
As search and rescue efforts continue following the deadly earthquake in western Colombia, the International Rescue Committee (IRC) has launched a response to assist the most vulnerable communities, including children.
MetroHealth Community Health Centers Secures Federal Funding to Strengthen Community-Based Care
MetroHealth Community Health Centers (MHCHC) was among 158 organizations nationwide selected to receive funding through a $102 million investment announced Thursday, August 13, by the U.S. Department of Health and Human Services and the Health Resources and Services Administration.
Nigel Farage beats Count Binface to win back seat in Parliament in widely mocked election
Farage, leader of the anti-immigration Reform UK party who some see as a possible next prime minister, abruptly quit his seat in July amid an investigation into whether he failed to report a 5 million pound ($6.7 million) gift from a crypto billionaire overseas.
Patriots Facing Unexpected Challenge Trading WR Kayshon Boutte
It’s the worst kept secret in the NFL that the New England Patriots are open to trading wide receiver Kayshon Boutte. That’s led to a new and unexpected issue. Getting the right value for him compared to what he brings to the team.The Patriots have a loaded wide receiver room, with as many as seven […] The post Patriots Facing Unexpected Challenge Trading WR Kayshon Boutte appeared first on HEAVY.
Apple sends fresh wave of mercenary spyware warnings worldwide
Apple has notified users in 110 countries who it suspects may have been targeted by spyware attacks. Here are the details.
What's Coming in September: New iPhones, Apple Watches and More
Apple will introduce at least five new devices at its iPhone-centric event next month, and it's also possible we'll get devices waiting on Siri AI like the Apple TV. iPhone 18 Pro The iPhone 18 Pro is going to look like the iPhone 17 Pro, but with a smaller Dynamic Island. It's getting some internal updates, including a new Wide camera with a variable aperture for more control over lighting and a faster A20 Pro chip built on a new 2nm process.
Businesses feel the strain as the deadline for Trump's 50% Canadian tariff approaches
If President Trump's threatened 50% tariffs go through later this month, construction businesses that rely on materials imported from Canada are among those that will suffer.
Q3 FY26: Largest Quarterly Audience in Global Sports Media History
In Q3 FY26, during the World Cup, ESPN Digital & Social had its best worldwide quarter of all time, pulling in 598 million global users per month,
NVIDIA GeForce NOW for Linux Officially Arrives
NVIDIA's efforts to enhance gaming on Linux operating systems are increasing. The company announced today that the official, native port of the GeForce NOW cloud gaming service client app is out of beta and now available for gamers worldwide. With months of community feedback integrated into the...
Ricketts Supports the Protect College Sports Act
WASHINGTON, D.C. – Recently, U.S. Senator Pete Ricketts (R-NE) joined the Protect College Sports Act. This legislation would end the disorder facing college athletics by establishing nationwide standards for name, image, and likeness (NIL), transfers, eligibility, and enforcement. “The Protect College Sports Act is a good step forward for athletics,” said Senator Ricketts. “This bipartisan bill addresses issues that were […]
Underrated 49ers Signing Could Pay Huge Dividends in 2026
The San Francisco 49ers' wide receiver has seen some big changes this offseason. Mike Evans was brought in to be the No. 1 receiver, and old favorite Deebo Samuel was brought back into the fold. Fellow receiver Ricky Pearsall went down for the year, which was a big blow.
49ers WR Ricky Pearsall reveals expected timeline for recovery
The San Francisco 49ers lost one of their top wide receivers for the year, but he has no regrets about the situation.
Poll: Are the Eagles Messing With Jalen Hurts?
The headaches have started early for the Philadelphia Eagles. The Super Bowl LIX champions have won 50 games in the last four seasons, yet it always seems like there’s a problem. Head coach Nick Sirianni is on the hot seat… Until he got traded, wide receiver A.J. Brown was a distraction… Every year, there’s a new offensive coordinator… And then there’s quarterback Jalen Hurts.
Treasury changes rules for businesses reporting ownership
The Biden-era regulation was intended to prevent money laundering, but critics said it was overly onerous.
Dave Canales on Xavier Legette: Really good to see him back to playing like himself
Panthers wide receiver Xavier Legette said in June that he "can’t have another year like I did last year" and the work he's done to turn things around has paid some dividends this summer.
After years of landslide victories, Klobuchar faces a tougher political fight against Demuth
The governor’s race will be Sen. Amy Klobuchar’s toughest test in a statewide election, following a series of easy reelections to the U.S. Senate. Republicans see Lisa Demuth as their best shot at capturing anger over fraud scandals and fatigue with the Walz administration.
10th Anniversary Celebration: Guaranteed Hundo Mewtwo Timed Research
Starts Wednesday, August 12, 2026, at 4:00 PM Local Time Ends Sunday, September 6, 2026, at 11:59 PM Local Time The Pokémon GO 10th Anniversary celebrations just got even bigger! Trainers worldwide will be able to claim a free Timed Research culminating in an encounter with a guaranteed 100% IV Mewtwo featuring a Special Background. […]
Eagles Linked to Interesting QB Trade Proposal With NFC Opponent
The Philadelphia Eagles appear to be a contender in the NFC once again. Even after trading star wide receiver A.J. Brown, the team looks set up for success.With preseason about to begin, the Eagles will have some tough roster decisions coming up soon. One of those decisions will come at the quarterback position.Obviously, Jalen Hurts […] The post Eagles Linked to Interesting QB Trade Proposal With NFC Opponent appeared first on HEAVY.
Asia-Pacific parliamentarians urge bolder action for universal health coverage, climate resilience and responsible AI
Parliamentarians representing 16 countries from across the Asia-Pacific region concluded the Ninth Meeting of the Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) today, reaffirming their key role in advancing universal health coverage (UHC) amid the risks and opportunities posed by AI and climate change. In adopting the Phnom Penh Communiqué, parliamentarians urged fellow legislators regionwide to strengthen sustainable financing for UHC to widen access to health for all, including the most vulnerable populations; promote responsible governance of AI amid ethical concerns over this fast-evolving technology; and build climate-resilient health systems to anticipate and respond to mounting pressures ranging from rising sea levels in coastal areas to air pollution and other environmental degradation.The National Assembly of Cambodia, with support from Cambodia’s Ministry of Health and the World Health Organization (WHO), hosted the Forum in Phnom Penh from 11 to 13 August 2026 – the first time the Forum has convened in a Mekong country.Parliamentarians urge action to close gaps in accessIn the Communiqué, parliamentarians recognized that at-risk and marginalized groups are the ones most severely affected by gaps in access to health services. These groups include people living in poverty, women and children, persons with disabilities, older people, migrants, refugees, and those in rural, remote or island communities. The Communiqué urges fellow parliamentarians and policy-makers to advocate for laws and policies that support sustainable financing to protect people from financial hardship, with a focus on primary health care, prevention and equity. "The Communiqué is a call to action. It sets out ambitious, concrete measures that deliver meaningful impact on the ground. We are all accountable for advancing universal health coverage and translating our commitments into tangible results. Cambodia is fully committed to advancing UHC, including the promotion of ‘healthy people, prosperous country’ campaign,” said Samdech Maha Rathsapheathika Thipadei Khuon Sudary, President of the National Assembly of the Kingdom of Cambodia.His Excellency Professor Chheang Ra, Minister of Health of the Kingdom of Cambodia, highlighted the need for collaboration beyond the health sector. “Universal health coverage cannot be achieved by the Ministry of Health alone. It requires support, particularly from parliamentarians, across political, legislative, financial, social protection, education, infrastructure, and environmental domains. While each country follows its own path, one factor is universally critical for success: strong governance and leadership. We all believe in this principle, and in our respective political roles, we remain committed to strengthening these key success factors to ensure that no one is left behind.”Promoting responsible AI adoption Parliamentarians acknowledged that, while AI has already demonstrated its ability to improve access to health services and support delivery, careful and ethical governance is necessary to safeguard quality, safety, privacy and public trust. This underscores the importance of parliamentarians in promoting legal and regulatory frameworks addressing liability, records ownership and data governance, while embracing innovation that protects ethical practice.“Without strong governance, safeguards for privacy and data security, sustainable financing, and attention to those most at risk of exclusion, new technologies may widen existing gaps instead of closing them. This is why parliamentarians matter. We pass laws. We approve budgets. We scrutinize government action. We represent communities. We can ask whether health services are reaching rural, remote, ageing, poor, and marginalized populations. We can ask whether innovation is being guided by equity, evidence, and ethics,” said Hon. Man Hee Lee, President of the Asia-Pacific Parliamentarian Forum on Global Health.Building climate-resilient health systemsParliamentarians also reiterated that the climate crisis is a direct threat to people’s health and to achieving UHC more broadly, deepening the same gaps in access already faced by at-risk and marginalized communities. They recognized the need for WHO Member States to ensure sufficient national appropriations and oversight, and for parliamentarians to raise awareness in their constituencies and mobilize local action in building climate-resilient and sustainable health systems.“Universal health coverage, climate change and AI cannot be addressed in isolation. The same communities struggling to access health services today are often the ones most exposed to climate shocks, and most in need of the opportunities AI can offer if this technology is governed responsibly,” said Dr Saia Ma’u Piukala, WHO Regional Director for the Western Pacific. “Having served previously in this Forum myself as a parliamentarian from Tonga, I recognize how the Phnom Penh Communiqué reflects the shared resolve of legislators across the Asia-Pacific region: the laws parliamentarians pass and the budgets they approve help ensure this progress reaches the people who need it most.”As the Forum drew to a close, delegates reflected on what they would carry back to their own parliaments and constituencies.“I wish to share three points here worth carrying home from Phnom Penh: we need to invest in primary health care as the foundation of coverage; we need to remove the barriers that keep people from care, whether financial, geographic or social; and we need to build systems that are inclusive by design, protecting those most at risk of being left behind,” added Hon. Ouch Borith, First Vice-President of the Senate of the Kingdom of Cambodia.###Notes for editors:The Asia-Pacific Parliamentarian Forum on Global Health (APPFGH) is a platform for parliamentarians to exchange ideas, build political will, strengthen capacity and foster collaboration towards sustainable health action. This was the ninth meeting of the APPFGH, with the theme “Universal Health Coverage in the era of Climate Change and Artificial Intelligence”. Target 3.8 of the Sustainable Development Goals calls on countries to achieve universal health coverage, including financial risk protection, access to quality essential health services, and access to safe, effective, quality and affordable essential medicines and vaccines for all. In the Western Pacific, UHC service coverage index (SDG 3.8.1) rose from 63 in 2000 to 81 in 2023 (figures include Indonesia), and roughly one in four people in the Western Pacific have experienced financial hardship (SDG 3.8.2). Progress towards UHC in the Asia-Pacific region remains uneven, with hundreds of millions of people still lacking access to essential health services or facing financial hardship due to health-related expenses. Strengthening the role of parliaments – through legislation, financing and oversight – is central to closing this gap and accelerating progress towards UHC across the region.Parliamentarians participating in APPFGH in Cambodia this week include: Hon. Pehin Dato Adanan YUSOF, Brunei Darussalam; Hon. Rosmawatty ABDUL MUMIN, Brunei Darussalam; Hon. LORK Kheng, Kingdom of Cambodia; Hon. YOS Phanita, Kingdom of Cambodia; Hon. KHOUN Khundy, Kingdom of Cambodia; Hon. HENG Halim, Kingdom of Cambodia; Hon. KHOENG Noupheap, Kingdom of Cambodia; Hon. SENG Nhak, Kingdom of Cambodia; Hon. LY Sukry, Kingdom of Cambodia; Hon. NHOEURN Raden, Kingdom of Cambodia; Hon. Dr Ratu Atonio LALABALAVU, Republic of Fiji; Hon. Vijay NATH, Republic of Fiji; Hon. Man Hee LEE, Republic of Korea; Hon. Dr Jiho CHA, Republic of Korea; Hon. Jonghun BAEK, Republic of Korea; Hon. Youngsuk SEO, Republic of Korea; Hon. Dr Phayvanh KEOPASEUTH, Lao People’s Democratic Republic; Hon. Suhaizan Bin KAIAT, Malaysia; Hon. Dr Perpetua KONMAN, Federated States of Micronesia; Hon. Ganmaa DAVAASAMBUU, Mongolia; Hon. Charmaine SCOTTY, Republic of Naoero; Hon. Vincent Ambance KUMURA, Papua New Guinea; Hon. Dr Edwin CRUZADO, Republic of the Philippines; Hon. AUUAPAAU Mulipola Aloitafua Mulipola, Samoa; Hon. ASIATA TAVUI Tafu Salevao, Samoa; Hon. Dr Alani Petelo TANGITAU, Tonga; Hon. Paul PAOLO, Republic of Vanuatu; Hon. Franklyn Ezra WILLIAM, Republic of Vanuatu.For more information, contact: WHO Regional Office for the Western Pacific: wprocom@who.int National Assembly of the Kingdom of Cambodia (International Relations Department): ir.nacambodia@gmail.com
Major supermarket chain closes at least 39 stores as nationwide overhaul takes shape
The grocery giant is closing underperforming locations across several banners, with some stores being consolidated into larger-format locations.
In Senate race, Flanagan and Tafoya bring vastly different politics, experience
Democrat Lt. Gov. Peggy Flanagan and Republican Michele Tafoya have come to politics from very different routes and backgrounds. As the two battle it out for an open U.S. Senate seat, analysts expect a large amount of money to flow into the race.
Broncos Depth Chart Reveals Surprise Twist at Wide Receiver
The 1st unofficial Denver Broncos depth chart revealed Marvin Mims Jr. as the 3rd starting WR before the preseason opener. The post Broncos Depth Chart Reveals Surprise Twist at Wide Receiver appeared first on HEAVY.
Claim that science is becoming less disruptive challenged after years-long publication delay
A widely cited Nature cover article from 2023 claimed that scientific innovation has significantly declined in recent decades. This finding was based on a citation analysis of large sets of metadata concerning ...
Wharton Shares Analysis of Connecticut’s Political Future
Dr. Jonathan Wharton, professor of political science and urban affairs at Southern Connecticut State University, recently joined “Face More Facts” on NBC Connecticut to examine the results of Connecticut’s historic primary election and discuss what they could mean for the state’s political future. The wide-ranging conversation covered the defeat of longtime U.S. Rep. John Larson, Gov. Ned […]
Panthers Might Be Without WR Xavier Legette For Preseason Opener
Carolina Panthers wide receiver Xavier Legette might not be playing in Saturday’s preseason game at the Buffalo Bills after suffering a stinger early in training camp.
In Good Health: Why Measles Numbers Are On The Rise
Nationwide, students, teachers, and parents are gearing up for the school year.And measles is spreading. The U.S. has already logged more cases this year than in all of 2025. It’s the highest count in 35 years. That’s in large part because measles vaccination rates have slipped below 95 percent – the threshold public health experts say is needed to stop community spread. Last week on CNN, Health and Human Services Secretary Robert F. Kennedy Jr. said children should be vaccinated for measles after being pressed on-camera, even as he used the same interview to push a debunked claim about respiratory syncytial virus. And on Monday, President Donald Trump signed an executive order aimed at upending the childhood vaccine schedule, including changes to the measles vaccine and others. But what will actually change at the doctor’s office?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
AI tools now widely available in Oracle Health's patient portal
New artificial intelligence capabilities can help patients understand care plans and medications, offer automated reminders of upcoming visits and prompt them to complete labs or schedule follow-up screenings.
Raiders roster 2026: Get to know Deven Thompkins
Veteran wide receiver was recently signed
Wide receiver Savion Williams turning heads in camp
The 2025 third round pick is getting some attention in camp.
8 Best Uses For The Samsung Galaxy Z Fold 8's Wide Screen
With its wide 4:3 inner screen, the passport-shaped Samsung Galaxy Z Fold 8 makes it easier than ever to read, write, game, and even work on mobile.
WORLDWIDE WEDNESDAYS: The Rise of A.I. Entertainment
NewsChannel 7’s Alyssa Dutton and Emmett Rice sit down with Producer Evan Bendall to discuss the rise of A.I. entertainment
NV lawmakers mull maternal health protections for '27 session, punt on child welfare funding fix
Nevada state lawmakers are considering a wide-range of health-related policies in the next year’s legislative session that includes implementing a slate of maternal health protections in a “momnibus” bill, bolstering efforts to investigate Medicaid insurance fraud, and reducing reporting requirements for state health agencies. Also at Tuesday’s interim Health and Human Services committee meeting, discussion […]
Study finds lasting mental health impacts on Lexington’s laid-off Tyson Foods workers
The closure of the Tyson Foods meatpacking plant in Lexington had wide-ranging effects on the city itself and the state's economy. But a team of researchers at UNMC focused on the lasting impacts on the laid-off workers.
Experimental Pulse Oximeter Accurate Regardless Of Skin Tone, Researchers Say
By Dennis Thompson HealthDay ReporterWEDNESDAY, Aug. 12, 2026 (HealthDay News) — Pulse oximeters became widely known during the COVID-19 pandemic, as doctors used the finger clip devices to tell whether a respiratory infection was robbing patients of needed oxygen. But skin tone impairs the ...
David Crowley defeats Francesca Hong in Wisconsin governor primary
Centrist David Crowley is projected to have beaten democratic socialist Francesca Hong, breaking a recent nationwide trend.
Siena poll: Hochul's lead over Blakeman narrows as voters weigh issues
Likely voters were also asked about statewide races for attorney general and state comptroller.
Scientists define a new category of heat wave: ‘Snow eaters’
Unseasonably warm weather that rapidly melts snowpack is becoming more widespread in the U.S. West and happening earlier in the year.
Scientists define a new category of heat wave: ‘Snow eaters’
Unseasonably warm weather that rapidly melts snowpack is becoming more widespread in the U.S. West and happening earlier in the year.
India plans insurance reforms to rein in healthcare costs, sources say
India is weighing wide-ranging reforms of health insurance, from benchmarked treatment rates to a nationwide claims exchange, as it looks to boost transparency in a struggle to hold down some of the highest medical inflation in Asia, two sources said.
NFL's best WR reveals two cornerbacks that are his kryptonite
Since the moment he stepped on an NFL field out of LSU in 2021, Ja'Marr Chase has been one of the best wide receivers in the league. The 81 receptions, 1,455 yards and 13 touchdowns he put up in his rookie season would be a career year for more than a few top-tier wide receivers. He has never had ...
Dan Campbell Makes Exciting Declaration About Lions' Wide Receiver Room
The Detroit Lions' offense has been one of the most productive units in the NFL over the past few years, and the wide receiver room has been a primary reason for their success. Obviously, the position group is fueled by the duo of Amon-Ra St. Brown and Jameson Williams. The pair complement each other very well, as St. Brown is a savvy route runner with exceptional hands, while Williams adds speed, explosiveness, and big-play ability.
De'Zhaun Stribling Continues Turning Heads at 49ers Training Camp
The San Francisco 49ers took a lot of heat when they drafted wide receiver De'Zhaun Stribling in the second round of the 2026 draft. The consensus on Stribling was that he should be a third-or-fourth-round pick. Instead, the 49ers took the Ole Miss product in the second, and many immediately called it a reach.
N.Y. data center tour coming to a stop near you?
The “NY Fights AI Data Centers” statewide tour is scheduled to visit 13 sites with data centers or proposed data centers across New York.
N.Y. data center tour coming to a stop near you?
The “NY Fights AI Data Centers” statewide tour is scheduled to visit 13 sites with data centers or proposed data centers across New York.
Crunchyroll, Sony Pictures Entertainment to Release Makoto Shinkai's Next Movie
Crunchyroll is announcing today that it has acquired the worldwide distribution rights (excluding Asia, but including India) for Makoto Shinkai's next feature film, with Crunchyroll and Sony Pictures Entertainment to co-distribute.
‘Everyone’ at Apple uses iPhone Ultra name, says Mark Gurman
Mark Gurman says that ‘iPhone Ultra’ is the name widely used within Apple when referring to the upcoming foldable model.
Anti-ICE protestors call out Susan Collins in Biddeford
Protestors took to the streets outside of the offices of U.S. Sen. Susan Collins (R-Maine) statewide, demanding she take responsibility for what they said was support of ICE.
Oklahoma Health Department reports 506 cyclosporiasis cases statewide
The Oklahoma State Department of Health has updated the cyclosporiasis numbers in Oklahoma, with 496 confirmed cases and 10 probable cases as of Tuesday, Aug. 1
Winchester families can now register for Cool Science Club
The following was submitted by the Cool Science Club: Registration for the Cool Science Club is now open for the summer of 2026! We are excited to welcome both new and returning students to the Cool Science Club for another summer of discovery! CSC offers a wide array of engaging,
Galaxy Z Fold 8’s wider shape still survives bend test, teardown shows off titanium and poor Qi placement [Video]
Durability is perhaps the single-biggest hesitation about folding phones, but Samsung has proven time and time again that its foldables...
Guenther and Ware for Real Clear Science: The Trump Administration’s Most Dangerous Attack on Science Yet
Donald Trump’s assault on the American scientific enterprise has been death by a thousand cuts. But the latest push from the Office of Management and Budget (OMB) may just be the kill shot. OMB proposed a rule to “improve government-wide policies and requirements related to the management of grants, cooperative agreements, and other forms of […]
One of the best AirPods Pro features is finally coming to Galaxy Buds
Samsung finally introduces a super-useful feature to its latest Galaxy Buds models.
Ari Emanuel’s Company to Acquire 7 Broadway Theaters and 10 in the West End
The purchase of ATG Entertainment, which operates dozens of venues worldwide, will require regulatory approval.
Blending Fusion Science, AI to Predict DIII-D Tokamak Behavior
Data scientists from the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility and partner institutions have developed a deployable machine learning (ML) framework that can adaptively predict changes in a magnetic confinement fusion research machine’s hardware. The innovative method, recently published in the journal Machine Learning with Applications, promises to help make the operation of fusion devices more stable and accelerate humanity’s pursuit of a superabundant
Emily Feng joins NPR's Politics and Policy Desk
In a note to newsroom staff, NPR Politics and Policy Desk Chief Editor, Dana Farrington, and White House Senior Editor, Rebekah Metzler, announced that Emily Feng is joining the Politics and Policy Desk as a White House correspondent.
ND Expert on democracy: Can better civics education restore voter dissatisfaction over political corruption?
This summer, America celebrated the 250th anniversary of the signing of the Declaration of Independence, widely recognized as the formal founding of our nation and one of the early stages of establishing a democratic government. Over the past two decades, however, democracies all over the world have struggled with a lack of clear support. Democracy scholars have referred to these challenges as evidence of backsliding, a phenomenon that has many political and social scientists concerned, including Notre Dame development economist Enrique Seira Bejarano.
Michigan Football trending up with ELITE wide receiver recruit
Michigan Football is trending up for an elite WR that is teammates with two recruits committed to the Wolverines. That and more in today’s Recruiting Roundup:
The U.S. Healthcare System is Already Mostly Socialized
Now that Abdul El-Sayed is the Democratic nominee for Michigan’s open Senate seat, the outcome of this crucial race will depend mainly on two things: Whether Republicans succeed in demonizing El-Sayed because he’s brown and a Muslim, and whether they succeed in demonizing him as a left-wing radical. I will defer for the now the question of whether bigotry will be effective this year, although I will address it another day. What I want to address instead is El-Sayed’s signature issue — healthcare. Yes, El-Sayed advocates Medicare for All, a position the usual suspects denounce as “socialism.” I will get to the politics of his stance soon. Today, however, I want to talk about the substance. We should be clear that El-Sayed doesn’t even call himself a socialist. On the contrary, he explicitly disavows the label, saying “I’m a capitalist who just knows about capitalism”. In fact, as I explained in a previous post, the policies that El-Sayed advocates qualify him as a social democrat, not a socialist. Still, El-Sayed advocates a system under which the government would pay almost all medical expenses. Isn’t that socialism? Well, if that is the criterion then much of U.S. healthcare is already socialist. In fact, the government’s role is so large that U.S. healthcare is better described as partially privatized socialism than as anything resembling a free market. Let’s start with the raw numbers on health insurance, which pays the bulk of Americans’ medical expenses. Americans receive health insurance either from private companies or from public programs, overwhelmingly Medicare and Medicaid. Here’s what the breakdown of coverage and spending between private and public looked like in 2024: While a majority of Americans with health insurance get it from private companies, well over 100 million of us are covered by government programs instead. And these government programs pay more total dollars for medical bills than the private insurers do. Why do government programs that cover a minority of the population account for a majority of health insurers’ outlays? Mainly because Medicare covers seniors, and we’re expensive. Also, while Medicaid covers many younger Americans, disabled and elderly beneficiaries account for most of its spending. Even by the raw numbers, then, U.S. health insurance looks as much public as private. But that understates the government’s role: Private health insurance in the U.S. is both highly regulated and heavily subsidized. This is obviously true for the insurance coverage purchased by tens of millions of Americans through the exchanges established by the Affordable Care Act. But employment-based health insurance, which covers 161 million Americans, is far more of a government creation than most people realize. For employment-based insurance exists largely because of huge implicit government subsidies that come with major strings attached. Here’s how that works. If your employer pays you $10,000, that’s taxable income. But if your employer pays $10,000 toward a company health insurance plan that meets certain criteria, it isn’t taxable. That’s a huge effective subsidy, running at more than $300 billion a year. Take that subsidy into account, along with the more than $100 billion per year spent subsidizing policies purchased under the ACA, as well as the outlays on Medicare and Medicaid, and net effect is that the government pays for more than two-thirds of Americans’ health insurance. Granted, there are strings attached. Roughly speaking, employment-based health plans can’t discriminate based on medical history — that is, they can’t deny coverage to employees with pre-existing conditions — and they also can’t offer the plans only to highly compensated employees — a health plan that is only for the C-suite is considered taxable income. So given the restrictions of the federal tax code, employer-based health insurance is a lot like Obamacare, which also prohibits discrimination based on medical history and provides subsidies to make insurance affordable to lower-paid workers. The fact is that virtually all of private healthcare insurance is already well under some form of government control through regulation and tax subsidies. How should we think about this system? First of all, is Medicare socialist? Don’t tell anyone, but the way Medicare operates — it covers every senior’s medical expenses, whatever they turn out to be, while being funded by taxes that depend on one’s income — could be summarized by the old Marxist slogan “From each according to his ability, to each according to his need.” And back in 1961, when Ronald Reagan was the face of a last-ditch effort by the American Medical Association to block the creation of Medicare, he denounced Medicare as “socialized medicine” and warned that it would destroy our freedom. In reality, American freedom survived until Jan. 20, 2025, while Medicare is immensely popular, with an 82 percent favorable rating in the most recent KFF survey. Medicaid, government health insurance for lower-income Americans, comes in at 73 percent. This is in sharp contrast to public views about private insurers, who are widely disliked if not hated and accused of denying essential care. Furthermore, if Medicare is socialism, then the whole U.S. health insurance system, with the government paying most of the bills and placing conditions on private insurers, is almost equally socialist. If you insist on calling any program the government pays for and regulates socialist, then U.S. healthcare would best be described as a partially privatized form of socialism. And one must ask, what is the point of the part that is privatized? Do private insurers add anything positive? Or are they simply parasites, skimming off money that could have been paying for care? The case for viewing insurers as parasites is strong. Many Medicare benefits are now delivered via Medicare Advantage, that is, plans paid for by the government but run through insurance companies. MedPAC, an independent advisory commission, estimates that last year Medicare Advantage plans were overpaid by $84 billion, thanks to practices such as “upcoding,” in which patients’ health problems are overstated to get larger sums from Medicare. Assessing the waste from employer-based insurance is harder, but most evidence suggests that private insurers have substantially higher administrative costs than Medicare does. Furthermore, the complexity of private insurance, with multiple payers all trying to deny care when they can, is a huge burden both on providers — doctors, nurses, and hospitals — and on patients. What do private insurers offer to compensate for these costs? One must go through intellectual contortions to avoid the conclusion that they are, in fact, parasites. Which brings me back to El-Sayed. In supporting Medicare for All, he’s basically calling for an end to the partial, parasitic privatization of a healthcare system that is already hugely dependent on public funding. When one looks at it that way, it’s not at all a radical proposal. Admittedly, the political lift requires overcoming the opposition to higher taxes to pay for Medicare for All. Political realism rather than economics was the reason I and many other progressives supported Obamacare, with all its complexities, rather than demanding an immediate move to Medicare for All. But the political calculus may very well have shifted since the 2000s, as Americans are fed up with a system of unaffordable premiums, rampant claim denials, and byzantine claim administration. Moreover, funding healthcare insurance through taxation would allow for a much more progressive distribution of the cost. That is, compared to the present system, middle-income households would pay less as high-income households would pay more. And the U.S. would stop wasting large sums on pointless administrative costs. So let’s be clear: El-Sayed’s healthcare platform is perfectly reasonable on the merits of cost, fairness and health efficacy. And with private insurers never more hated, while millions of Americans are losing their health insurance, 2026 may be its time. MUSICAL CODA
Greg Dortch impressing in camp as potential fourth Lions receiver
Thanks in part to his familiarity with Drew Petzing, Greg Dortch could emerge as both a top specialist and No. 4 wide receiver.
Trump-Netanyahu rift widens as election pressures pull them in opposite directions
While the Israeli leader touts a willingness to defy the U.S. on Gaza, the president needs to show progress in the foreign entanglements weighing on his approval rating.
We finally know the real "Dark Cherry" color for the iPhone 18 Pro
The iPhone 18 Pro is one of the most anticipated devices, and now, thanks to a new leak, one big debate has finally been settled.
Millennium Hotels and Resorts Partners with HXE to Strengthen Global MICE Business Through Digital Innovation
Millennium Hotels and Resorts (MHR), a global hospitality leader with a portfolio spanning key destinations worldwide, has entered into a Strategic Partnership Program agreement with HXE in Singapore. The partnership combines MHR's global hospitality network with HXE's digital MICE platform to create new opportunities for corporate meetings and events while supporting the growing demand for seamless, technology-enabled event planning.
Leaked Galaxy S26 FE specs confirm another battery disappointment from Samsung
Samsung doesn’t seem to even try to surprise anyone with its next Fan Edition phone.
Saber's newest game trailer takes a shot at Gearbox's CEO, if you look closely
The first hint that something might be up with the recent debut trailer for Saber Interactive’s Rideshare Stimulator is an unusual choice of words—aside from that second one in the game’s title. “Don’t take your passengers too seriously,” the trailer’s narrator says, as he describes this upcoming game. It a car game about the gig work of driving eccentric people to their destinations, a riff on Crazy Taxi. And then, he says: “When I think I’ve met the randiest of passengers, someone even stranger gets in.” “Randiest”? That suggests “randy,” which usually means having strong sexual desire. Yet none of the oddball backseat occupants featured in the trailer seem particularly lustful. One is an old man who considers his grandson a failure, another shares the theory that birds might control traffic lights, another says he’s banned from an aquarium. A little later, there’s a license plate, shown 63 seconds into the trailer, on the front of an SUV: USB DRV It’s a Texas plate. The symbol between those letters is a cog wheel. If you know, you know. That’s a reference to Texas-based Borderlands game development studio Gearbox Software (their logo features a cog wheel). More specifically, it’s a reference to Gearbox’s CEO Randy Pitchford, who in 2018 found himself explaining the nature of video he’d saved on a USB drive that was found at a Medieval Times restaurant before being returned to the studio: “It was ‘barely legal’ porn. This girl’s handle was ‘Only 18.’” The “girl” in the video had committed a solo sex act that Pitchford, an avid practitioner of magic, found remarkable. “I realized, this is not a sex worker…This is a fucking magician.” Back then, the USB drive was central to competing lawsuits against Gearbox by the studio’s former lawyer and by Gearbox against him. A settlement in late 2019 “exonerated” Pitchford, per the Hollywood Reporter. The USB story has resurfaced at times, now in a trailer from a company that not long ago was corporate brethren with Gearbox. Saber vs. Gearbox The head of Saber told Game File that the reference is payback. “The dig is because Randy took shots at Embracer in Borderlands 4,” Saber CEO Matt Karch told me when I asked him about the license plate. “Without Embracer, Randy is performing magic tricks at birthday parties for a living.” Having interviewed Karch during a cross-country flight in late 2024, I can confirm that Karch was unimpressed with Pitchford during their time both working in the Embracer group. I’d approached him not out of surprise that there was animosity but that it was manifesting publicly now. Gearbox was founded in 1999, worked on a port of Halo early on, and developed hit series such as the loot-based sci-fi shooter Borderlands before it was purchased by The Embracer Group in early 2021 for $363 million (with a possible earn-out of over $1 billion, if certain targets were hit by 2027). Saber was founded in 2001, worked on a remaster of Halo early on, had a big hit with zombie shooter World War Z and was purchased by Embracer in early 2020 for $150 million, with a potential earn-out of up to $375 million. For a few years, the Embracer group was a voracious acquirer of game studios. Then, as investment dried up, it choked. In March 2024, Embracer sold Saber to an investment company controlled by Saber CEO Matt Karch, and it sold Gearbox in an all-stock deal to long-time Borderlands publisher Take Two Interactive. Other studios were shut down. Hundreds of developers were laid off. Gearbox didn’t say much about their Embracer experience, nothing too direct, at least. In the summer 2024, Pitchford told reporter and occasional Game File contributor Nicole Carpenter that Borderlands 4’s story was in some way thematically connected to Gearbox’s experience at Embracer: “There’s this cultural and emotional shift in me, personally, and at the studio. What does it mean to trade some autonomy for organization?” When Borderlands 4 came out, there was something stranger: the matter of “Embracer’s Bluff,” a location in the game featuring an AI-powered toilet and a large trash dump, according to a detailed Kotaku account of the place. Gearbox never commented on it; Take Two never got back to me about it when I asked them last year. By contrast, since Saber exited Embracer, Karch has been one of Embracer’s biggest defenders, casting their management as well-meaning and supportive despite the layoffs and studio closures that resulted from their excessive expansion. Like others, Saber’s Karch saw Embracer’s as a shot. With Rideshare Stimulator’s trailer, he’s returned fire. “It’s amazing to me how fast people forget those who went above and beyond for them,” Karch told Game File. A rep for Gearbox did not comment by press time. Game File is a reader-supported publication. Your backing makes my reporting—including any coverage of trailer-based beefs—possible. Good news! I’m currently running Game File’s first big sale of 2026. You can get a one-year subscription for 23% off. Click here to take advantage of the limited-time offer. And thank you for your support! Item 2: In brief… 🚫 Wal-Mart has laid off the staff of Restart, a games media outlet launched in 2024, Aftermath reports. 🟥 A GTA VI preview is on the way, at last, via an “extended look” that will premiere, unusually, on Netflix at 3pm ET on August 27, then officially go live elsewhere six hours later. Last week, Game File noted that Take Two label Rockstar Games is overdue for showing off GTA VI, based on the timing of the initial hands-off previews of GTA V and Red Dead Redemption 2. During a call with investors, Take Two CEO Strauss Zelnick said pre-orders for GTA VI were “unprecedented and astonishing,” but added the company can’t predict how many of those pre-orders represent bonus sales vs. sales that otherwise would have been made at launch. During the same call, Zelnick was noticeably bullish on the future of playing games over streaming cloud connections (predicting wider adoption in three or so years). He sounded unbothered by Sony’s plans to stop making discs for new games (he said the business is 90% digital already and predicted that there could still be limited edition physical editions of games “in the same way there’s still vinyl in the recorded music business.”) 👀 Take Two wrote off $43 million in their spring quarter after deciding “not to proceed with further development of an unannounced title in its pipeline from a third-party developer.” 🤔 Some rare age-demographics from a big publisher: Capcom recently told investors that “users in their 20s account for approximately half of the users of both Pragamata and Resident Evil Requiem.” Item 3: The week ahead Tuesday, August 11 Game releases: The Elder Scrolls IV: Oblivion Remastered (Switch 2; already out for PC, PS5, Xbox) continues the Bethesda strategy of putting Elder Scrolls games on everything; Royalty Free-For-All is a Smash Bros.-style fighting game featuring public domain characters such as Mother Goose brawling with Oliver Twist in a stage based on the original Little Shop of Horrors movie. Wednesday, August 12 Game release: Pro Jank Footy (PC, console) is an arcade-style Australian Rules Football game with increasingly ridiculous rules, the more you play (I enjoyed the Steam demo) Thursday, August 13 Game release: Super Mario Sunshine (Switch 2, originally released in 2002 on the GameCube) is released for Switch 2’s Nintendo Switch Online service. This game is the black sheep of 3D Mario games. It’s the successor to the breakthrough Super Mario 64 and the rare Mario game built around a single (vacation resort) theme. Mario’s got a water-spraying backpack, a Yoshi pal and a lot of blue coins to collect.
82 northeast Minnesota businesses sign letter to lawmakers requesting wildfire relief funds
The letter comes after Gov. Walz said there would not be a special session held to address the economic impacts of the fire.
Report: Samsung is increasing the Galaxy Z Fold8 production target for this year by 1 million units
The new wide format foldable has already proven to be more successful than even Samsung had hoped. The Samsung Galaxy Z Fold8 has proven to be more...
Study links student gambling problems to mental health
As gambling becomes more accessible to college students, a statewide study of Mississippi's public universities found gambling problems frequently occur alongside depression, anxiety and substance use.
Gavin Newsom's 'hidden climate tax' hitting Americans nationwide, lawmaker warns
Rep. Vince Fong targets the EPA-authorized vessel at berth regulation that lets California levy massive penalties on cargo ships docked at its ports.
Underdog WR continues to get meaningful practice reps for Patriots
Patriots wide receiver Efton Chism III has quietly continued to get some work with the top offensive unit.
Scientists Release Biggest 2D Map of the Universe
Key Takeaways The DESI Legacy Imaging Surveys combined more than 263,000 telescope exposures to make the largest 2D map of the universe in visible and near-infrared light. Astronomers can pair the Legacy Surveys map with their own observations to explore our universe and search for rare phenomena. The 2D map serves as the foundation for the Dark Energy Spectroscopic Instrument survey to measure the universe in 3D and investigate dark energy. Hold on to your telescopes: the DESI Legacy Imaging Surveys team has released the largest-ever 2D color map of the universe. The 5.6-trillion-pixel map contains nearly 4 billion celestial objects, primarily stars and galaxies. The data is available for all to use and publicly viewable through the Legacy Survey Sky Viewer. Astronomers and citizen scientists can explore the map or combine it with their own observations to better understand our universe. Researchers can search for rare phenomena like gravitational lenses, observe fleeting events like supernovae, and investigate two of physics’ biggest mysteries: dark matter, the invisible substance that accounts for most of the mass in our universe, and dark energy, the force driving our universe’s accelerating expansion. The new map builds on earlier versions from the DESI Legacy Imaging Surveys that have already proved invaluable. To date, more than 1,800 science papers that reference the Legacy Surveys data have been published. “It’s part of the fabric of astronomy research now,” said David Schlegel, a co-lead of the Legacy Surveys and scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab). “When you’re working with astronomical objects today, you often start by pulling up the Legacy Imaging Viewer to see what you’re looking at.” Covering roughly 75% of the sky in visible and near-infrared light, the updated map provides a deep view of the extragalactic universe not blocked by the dust and stars of our own Milky Way. Researchers expect it will remain the most comprehensive 2D map of our universe for years to come. More than 160 scientists contributed to data collection for the project, and a team of 20 produced the final dataset released today. It was built by combining 263,407 telescope exposures from three ground-based sky surveys: the Dark Energy Camera Legacy Survey (DECaLS) at NSF Cerro Tololo Inter-American Observatory, the Mayall z-band Legacy Survey (MzLS) at NSF Kitt Peak National Observatory, and the Beijing-Arizona Sky Survey (BASS) at the University of Arizona’s Steward Observatory. That was supplemented by years of data from NASA’s Wide-field Infrared Survey Explorer (WISE) satellite mission and additional public data. “For our team, these data are fundamental to our investigation of the expansion history of the universe and the formation of our galaxy,” said Arjun Dey, co-lead of the Legacy Surveys and an astronomer at NSF NOIRLab. “But the skies belong to everyone, and this survey gives everyone the chance to explore the sky and marvel at its wonders.” Here be galaxies The DESI Legacy Imaging Surveys were originally conducted to prepare for the Dark Energy Spectroscopic Instrument (DESI) survey. The Legacy Surveys’ 2D map is essentially a deep photograph of the sky; it records where galaxies and stars appear and how bright they appear. This crucial step enables DESI to select objects and measure their light in different wavelengths to determine their distances, building the largest high-resolution 3D map ever made. Scientists study the way galaxies have clustered at different ages of the universe to track dark energy over time. In April 2026, DESI completed its original five-year survey ahead of schedule and with vastly more objects than expected. The early results have shown surprising hints that dark energy’s impact may be weakening over time — a paradigm shift that could potentially shape the predicted fate of our universe. DESI expects to publish improved results using their first five years of data in 2027 and is continuing observations into 2028. DESI was so efficient at observing galaxies, the Legacy Surveys map needed to expand. Early on, “it became clear we might run out of galaxies to look at and run out of sky, and we better start doing something about that,” said Schlegel, who also works on DESI. The new Legacy Surveys map has been used to select DESI targets since June 2026 and will guide the telescope’s operations over the coming years. Computing the cosmos Merging hundreds of thousands of images taken on 2,285 nights, each with unique atmospheric and telescope conditions, was a massive computational effort. It took about a year to develop the computer code and eight weeks to process all the images at the Perlmutter supercomputer at the National Energy Research Scientific Computing Center (NERSC) at Berkeley Lab. Beyond supporting DESI, the Legacy Surveys will be a foundational reference for the next generation of telescopes. As new observatories like the NSF-DOE Vera C. Rubin Observatory (jointly funded by NSF and DOE’s Office of Science) and NASA’s Nancy Grace Roman Space Telescope come online, researchers can compare their observations with one of the deepest and most comprehensive views of the sky ever assembled. The Legacy Surveys data will also help scientists train artificial intelligence tools to analyze petabytes of astronomical data and accelerate new discoveries. It will be among the datasets used in an astrophysics pilot project within the American Science Cloud, part of the DOE’s Genesis Mission. The DESI Legacy Imaging Surveys are supported by the U.S. Department of Energy’s Office of High Energy Physics; the National Energy Research Scientific Computing Center, a DOE Office of Science user facility; the U.S. National Science Foundation, Division of Astronomical Sciences; and the partner institutions. DESI is supported by the DOE Office of Science and NERSC. Additional support for DESI is provided by the NSF; the Science and Technology Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the Secretariat of Science, Humanities, Technology and Innovation (SECIHTI) of Mexico; the Ministry of Science and Innovation of Spain; and by the DESI member institutions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
As Sky-High Health Care Costs Top Voter Concerns, Families USA’s Stop the Bleed: Cut Costs, Not Care Campaign Gains Nationwide Momentum
SEIU, MomsRising, Community Change, Popular Democracy, Main Street Alliance, Small Business Majority, and Others Join Effort to Rein in High Health Care Costs WASHINGTON, D.C. — Families USA announced today that its Stop the Bleed: Cut Costs, Not Care campaign is now officially active in all 50 states. Launched in January, Stop the Bleed is […]
Steelers sign former Jets WR, teammate of Aaron Rodgers
The Pittsburgh Steelers sign another wide receiver.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.