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USC scientists discover a hidden Alzheimer’s trigger and a possible way to shut it down
USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gene. The compounds target cPLA2, an enzyme that seems to fuel harmful inflammation while also being important for normal brain activity.
Man arrested for posing as fire system inspector, targeted minority-owned businesses
Fire investigators say Wesley Shaw ran an unlicensed business called Tennessee Fire Specialty Systems, where he posed as a licensed fire inspector to business owners. He charged hundreds of dollars per inspection for inspections he wasn’t qualified to perform.
Report Paratici targeted by Milan as new director of sport
Fabio Paratici only accepted the Fiorentina job in February, but multiple sources claim he is being targeted by Milan to be their new director of sport.The Rossoneri are having a complete clear out of...
Penguins Have 3 Trade Targets To Consider From Flames
FBI warns of Kali365 phishing service targeting Microsoft 365 accounts
The FBI is warning about the Kali365 phishing-as-a-service platform (PhaaS) that is used to hijack Microsoft 365 accounts by abusing OAuth device code authentication to steal session tokens and bypass multi-factor authentication (MFA).
The World Health Assembly adopts updated Global Action Plan on Antimicrobial Resistance (2026–2036)
Geneva, 23 May 2026 – Member States at the Seventy-ninth World Health Assembly (WHA79) adopted the updated Global action plan on antimicrobial resistance (GAP-AMR) 2026–2036, marking a major milestone in the global response to antimicrobial resistance (AMR) and delivering on a key commitment contained in the 2024 United Nations General Assembly Political Declaration on AMR. The updated plan was developed through a consultative process led by the Quadripartite organizations – FAO, UNEP, WHO and WOAH – with extensive engagement of Member States and stakeholders across sectors. AMR remains one of the most significant global health and development challenges, affecting humans, animals, plants, food systems and the environment. The updated GAP-AMR provides a comprehensive One Health framework to guide coordinated global, regional and national action over the next decade. It builds on the foundation established by the original GAP-AMR adopted by the World Health Assembly in 2015 while reflecting evolving evidence, lessons learned, and the commitments made at the 2024 UN High-Level Meeting on AMR. During the Assembly, Member States expressed broad support for the updated plan and its strengthened multisectoral and One Health approach. Delegates highlighted the importance of prevention-first interventions, including infection prevention and control, water, sanitation and hygiene (WASH), vaccination, biosecurity, and environmental measures. They also highlighted the need for responsible, equitable and sustainable use of antimicrobials, strengthened surveillance, innovation, and sustainable agrifood systems. The updated GAP-AMR is intended to serve as the global framework for coordinated action against AMR through 2036. It aims to accelerate global progress towards the commitments and targets agreed by Member States and support countries in developing, implementing and financing ambitious multisectoral national action plans. The plan also reinforces the importance of accountability, monitoring and reporting, sustainable financing, and international cooperation to address AMR through a One Health approach. The adoption of the updated GAP-AMR reflects renewed global commitment to preserving the effectiveness of antimicrobials and safeguarding advances in human, animal and plant health, food security, economic development and environmental sustainability. As implementation begins, continued collaboration among governments, international organizations, civil society, academia and the private sector will be critical to translating commitments into measurable impact. The Quadripartite organizations will continue supporting Member States and partners in operationalizing the updated GAP-AMR and advancing coordinated One Health action against AMR at country, regional and global levels.
AMD Zen 7 "Grimlock" reportedly targets TSMC A14 node for 2028
AMD Zen 7 “Grimlock” may use Powertech FOPLP packaging Commercial Times claims AMD is preparing next-generation CCDs may use TSMC A14. AMD has reportedly
Semiconductor decoupling. Powell's politics. Industrializing Ogaden. Free trade and the Magna Carta.
Thank you for opening your Chartbook email. Feliks Topolski, 1907-1989 8th Army’s Front, Italy 1944 Semiconductor decoupling Source: FT One thing that Jerome Powell deeply understood is that chairing the Fed under current conditions is a deeply political job. “Powell has successes and mistakes to his name. But he stands out as having thought more carefully about the Fed’s democratic legitimacy than any chair since Paul Volcker,” said Paul Tucker, a former deputy governor at the Bank of England, referring to the Fed chair who successfully fought the great inflation of the 1970s and early 1980s. … While Powell was at the Treasury in the early 1990s, he watched Alan Greenspan build relationships within the government. That convinced Powell he needed to follow the former Fed chair’s lead and spend more time in Congress than his predecessors Yellen and Bernanke. “The accountability for the Fed runs through Congress,” said Claudia Sahm, a former Fed official who is now chief economist at New Century Advisors. “That’s not just about having people on speed dial — it’s answering questions, explaining policy and getting feedback.” Source: FT Ethiopia’s PM Abiy and Nigerian business tycoon, with Chinese engineering, are driving industrialization in Ogaden/Somali region of Ethiopia. - Michael Masri’s reporting for Africa Report if fascinating. Ethiopia has launched a cluster of large industrial schemes in the Somali region, laying foundation stones for a urea plant and an oil refinery in Gode while opening the first two phases of the Ogaden LNG project. Abiy Ahmed framed the push as part of a broader strategy to link energy, agriculture and industry. “These projects embody more than industrial growth,” he said. “They represent our shared responsibility to harness opportunities, strengthen co-operation and promote peace.” The Gode urea plant, backed by Dangote Group and Ethiopian Investment Holdings (EIH), is designed for 3m tonnes a year. Dangote owns 60%, while EIH holds 40%. Officials say Dangote’s equity totals about $2.5bn, while the state provides land and implementation oversight. Gas from the Calub fields will be piped 108km to the site. Construction is slated for 40 months, with operations targeted for 2028. Ethiopia imports most of its fertiliser, spending more than $1.2bn a year for 1.5m–2m tonnes. Usage was roughly 1.7m tonnes in 2023, almost half of it urea, and demand for 2024–25 is put above 2.4m tonnes. If delivered on time, the Gode plant could cover domestic needs and allow exports to neighbours. Brook Taye, chief executive of EIH, called the venture “a significant milestone in the journey toward industrial self-sufficiency”. Dangote told the groundbreaking crowd that the complex would be integrated with gas supply and a polypropylene unit to support local inputs. He pointed to Ethiopia’s Grand Ethiopian Renaissance Dam (GERD), with a capacity of more than 5,000MW, and noted his group’s cement operations and expansion plans. The Gode refinery is being developed by Golden Concord Group of China. It is designed to process 3.5m tonnes a year of crude and condensate from the Hilala field, with associated storage. Backers say it will ease foreign-exchange pressure from fuel imports and anchor further industrial activity, including a proposed steel smelting site in Dire Dawa. GCL’s chair, Zhu Gongshan, cast the project as “a key step in Ethiopia’s path to energy sovereignty”, underscoring the Beijing–Addis ties. Financing details are still being finalised, but the refinery is central to the government’s energy-security narrative. Source: The Africa Report Dangote’s Ethiopian vision: Dangote began with cement. His crown jewel, Dangote Cement, dominates Nigeria’s market and has 10 operations in other nations in Africa. The formula has been consistent: identify sectors with chronic shortages – cement, fertiliser, sugar – commit massive local investments, and scale up to serve regional demand. Ethiopia was a natural extension of that model. In 2015, Dangote launched the Mugher Cement Plant outside Addis Ababa at a cost of $600m, with an annual capacity of 2.5 million tonnes. The investment gave him a firm foothold in one of Africa’s fastest-growing construction markets. But success came with risks. In May 2018, violent unrest led to the killing of Dangote’s country manager and temporary shutdowns at Mugher. While other investors might have retreated, Dangote doubled down. Today, he is preparing to spend $400m to expand Mugher’s capacity to 5 million tonnes, alongside a new grinding unit near Addis Ababa. Cement is just one market Dangote is targeting. Ethiopia’s enormous state-controlled sugar industry, long plagued by inefficiency and debt, has struggled for years to reform. Its Omo Kuraz Sugar Development Project, touted as one of the continent’s largest initiatives, continues to face delays and mismanagement. … The most ambitious venture of all is the planned fertiliser production complex in Gode, Somali region. Publicised on 28 August 2025, the Dangote Group and Ethiopian Investment Holdings (EIH) deal plans one of the world’s largest single-site urea manufacturing plants. The project costs an estimated $2.5bn and has an estimated capacity of 3 million metric tonnes annually, a rate that would not only render Ethiopia independent, but even a net exporter of fertiliser. EIH, the state wealth fund of Ethiopia, will hold 40%, while 60% is held by Dangote Group. … For Dangote, Ethiopia is a trifecta: Cement demand is projected to grow by 10% annually, its sugar consumption is growing with rapid urbanisation, and fertiliser demand is all but insatiable, given that farming supports the livelihood of 70% of Ethiopians. Source: The Africa Report The stakes for Abiy are high: For Addis Ababa, the $4bn fertiliser project in Ethiopia’s Somali region is no longer simply a manufacturing investment. It is increasingly being framed as a strategic state project tied to food sovereignty, import substitution and the government’s broader attempt to build economic resilience under mounting fiscal pressure. “Becoming self-sufficient in food is our main agenda,” Abiy says during the visit. “Land is needed; we have it. Water is needed; we have it. Human resources are needed; we have it.” The scale is enormous even by African industrial standards. Once operational, the plant is expected to produce three million metric tonnes of urea annually, potentially making it one of the continent’s largest fertiliser complexes. Ethiopian officials say the project now includes a 110km gas pipeline, a 120MW power plant, a polypropylene packaging facility and a two-million-tonne NPK blending plant. For a government grappling with chronic foreign exchange shortages, ballooning import bills and pressure on agricultural productivity, the numbers matter politically as much as they do economically. The decision to anchor the project in Gode is deliberate. Long viewed as peripheral to Ethiopia’s industrial economy, the Somali region is now being repositioned by the federal government as a future irrigation and agro-industrial corridor. Officials argue that the area’s vast land reserves and access to water could eventually support large-scale commercial farming capable of reshaping Ethiopia’s food economy. The government is simultaneously building housing infrastructure for about 5,000 residents near the plant, while officials project broader industrial expansion along the corridor. Abiy goes further, comparing the long-term revenue potential of the Gode development zone with Ethiopia’s flagship state enterprise. “The investments we are making in this Gode area, combined, will generate high revenue for Ethiopia, at par with Ethiopian Airlines,” he says. Source: The Africa Report Feliks Topolski 1907-1982 Topolski’s Chronicle, ‘Nazi Revival’, Vol. 8, Is. 1-2, 1960 HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. Photo by Jakub Dziubak on Unsplash If you are persuaded to click, please consider the annual subscription of $50. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Grim vision of drone warfare by Sylvie Kaufmann For contributing subscribers only. Subscribe The state of the art in Colbert-studies. Jean-Baptiste Colbert was Louis XIV chief minister from 1661 to 1683 and traditionally seen as an architect of absolutism and mercantilism. Alexander Hamilton later cited him as an inspiration in 1782. Now his legacy is disputed. Daniel Dessert, the chief critic, sees Colbert as the orchestrator not so much of an absolutist state as of an elite cabal. Would be great to have a good English-language review of this important debate. Source: lhistoire Didn’t know that the Magna Carta included free trade provisions Fighting for the right to the beach in Oregon in 1967: Source: Research Gate RAF Station – British and Polish Flags, c. 1940-45, The Ingram Collection Feliks Topolski, 1907-1989 ink and wash If you’ve scrolled this far, you know you want to click: Subscribe
Trade Target: Red Wings’ Center Problem Needs Attention
The post Trade Target: Red Wings’ Center Problem Needs Attention appeared first on Detroit Hockey Now. Arguably, the Detroit Red Wings possess the deepest pool of goaltending prospects in the NHL. In future considerations, the team […] The post Trade Target: Red Wings’ Center Problem Needs Attention appeared first on Detroit Hockey Now.
How The Sphere Entertainment (SPHR) Investment Story Is Shifting With New Targets And Projects
Analysts have lifted their fair value estimate for Sphere Entertainment from $136.36 to $161.00, pointing to a higher price target in updated models. That shift lines up with a wave of research that includes higher targets, rating upgrades and new coverage as more institutions focus on the company’s project pipeline and potential role in industry deal discussions. As you read on, you will see how to track these changing views and what to watch as the Sphere Entertainment story evolves. Stay...
Workplace partners: Rogue Valley medical team targets employee health and recovery
Through occupational health and injured worker care, Valley Immediate Care helps keep southern Oregon on the job When someone is injured on the job, the last thing they – or […]
Epic Games Tips Unreal Engine 6 Timeline With Rocket League Reveal, Targeting UE5’s Multithreading Wall
Epic Games hints at Unreal Engine 6 through Rocket League. Tim Sweeney's earlier comments point to a multithreaded future for the engine.
CVS Health (CVS) Price Target Boosted by $8 at Mizuho
With an annual dividend yield of 2.84%, CVS Health Corporation (NYSE:CVS) is included among the 12 Best Dividend Stocks to Invest in According to Hedge Funds. America’s leading health solutions company, CVS Health Corporation (NYSE:CVS) provides advanced health care from pharmacy services and health plans to health and wellness. On May 20, Mizuho bumped up its price […]
Report Crespo targeted by Lazio and Parma as new coach
Hernan Crespo could be heading back to Serie A for his first top coaching job in Italy, with his former clubs Lazio and Parma said to be interested.According to Tuttomercatoweb, Crespo is looking for ...
Across the globe, female politicians are increasingly being targeted...
Across the globe, female politicians are increasingly being targeted with sexualized AI-generated content. For women in politics, sexualized deepfakes have become a tool for humiliation,...
Agitators united by Chinese money, hate for America target data centers, experts warn
Experts warn climate activists, anti-Israel protesters and other movements have formed an anti-American alliance now targeting U.S. AI infrastructure.
Pancreatic cancer seemed ‘undruggable,’ then scientists cracked a key target
An experimental pill has shown unprecedented success, upending conventional wisdom about the disease.
Pancreatic cancer seemed ‘undruggable,’ then scientists cracked a key target
An experimental pill has shown unprecedented success, upending conventional wisdom about the disease.
Spencer Pratt isn't running on MAGA. He's running on frustration.
Pratt is gaining ground because he hasn't presented himself as a traditional establishment Republican. Instead, he's targeting a very specific voter.
WATCH: Republicans shrug off fears that Trump targeting GOP incumbents could backfire on agenda
House Republicans brush aside fears over Trump backing primary challengers against GOP incumbents after Rep. Thomas Massie's Kentucky defeat.
📋 Flu named to face Mirassol and target second place
At Maião, in the interior of São Paulo state, Fluminense and Mirassol face off this Saturday (23) at 7:00 p.m. (Brasília time) in the 17th round of the 2026 Brasileirão.The Rio Tricolor sits in th...
These special phone and app features can help protect you from spyware
Apple, Meta, and Google offer special security modes that provide your devices more secure against targeted spyware attacks. Here are how those modes work, what they do, and how to switch them on.
As Communities Warn of Health Risks, New York Will Weaken Its Landmark Climate Law
Gov. Kathy Hochul has announced revisions to the state’s greenhouse gas emissions targets that will push off its 2030 deadline. Organizers believe residents are already suffering.
As Trump Weighs Return to Conflict in Iran, Here’s What Could Be Targeted Next
There is no shortage of targets should President Trump, in coordination with Israel, decide to resume the assault on Iran.
42 scientists warn Ireland over accounting trick that could add 9 million tons of pollution
"What worries us as scientists is that other countries are now seriously weighing these targets."
Lawsuit Argues Trump’s $1.8 Billion Fund Excludes Those He Targeted
The constellation of individuals and groups involved claims to have suffered partisan attacks by the federal government under Trump, yet would not be compensated.
Trump’s ‘Anti-Weaponization Fund’ hit with another legal challenge
The Trump administration’s newly created nearly $1.8 billion fund for allies of President Donald Trump who say they were wrongly targeted by the government was hit with a second lawsuit on Friday, adding to the growing legal and political backlash facing the White House.
Bellevue teens targeting salmon die-offs and mental health win big at international science fair
Lakshmi Agrawal, a senior at Interlake High School, and Anusha Arora, a sophomore who also attends Interlake, were among more than 1,700 students from roughly 60 countries who competed at the Regeneron International Science and Engineering Fair in Phoenix.
Crypto’s bare-knuckle politics come to climate
The crypto industry went from regulatory target to political kingmaker in one election cycle. Can clean energy and climate tech do the same?
Israeli attacks kill several in Lebanon, with health workers targeted
More than 400 people have been killed since the ceasefire came into effect in mid-April.
World Health Assembly endorses resolution on precision medicine
At the Seventy-ninth World Health Assembly, Member States endorsed a new resolution on Precision medicine: a path towards targeted, personalized and equitable care, taking an important step towards advancing precision medicine as part of efforts to strengthen equitable, effective and sustainable health systems. Precision medicine refers to the use of clinical, molecular, genomic and other health data to inform prevention, diagnosis and treatment, taking into account variability while applying appropriate ethical and legal safeguards. When integrated responsibly into health systems, precision approaches can improve outcomes across different disease areas and across the life course – from cancer and rare diseases to infectious diseases, maternal, newborn and child health, mental health and noncommunicable diseases. The resolution reflects rapid advances in genomics, diagnostics, data science and digital health, alongside widening global inequities in access to these innovations. Many populations – particularly in low- and middle-income countries – remain underrepresented in data and research, limiting the public health impact of precision medicine and risking the widening of health disparities if action is not taken now. "Precision medicine is not an aspirational idea for health delivery in the future – it is already transforming lives across the world. But its benefits remain out of reach for too many and the research driving progress is concentrated in high income countries. This WHA resolution gives global health leaders, ministries of health, and WHO a clear mandate: to act. From infant screening to setting up genomic databases WHO will work with countries to bring about the power of these innovations." Dr Meg Doherty, Director Science for HealthThrough the resolution, Member States commit to developing and strengthening national policies, infrastructure, workforce capacity and governance frameworks to support the safe, ethical and equitable integration of precision medicine into health systems, aligned with universal health coverage. This includes promoting affordability, ensuring inclusive research and data systems, strengthening regulation and data governance, and fostering collaboration across sectors and regions.WHO is requested to provide technical and normative support, review and coordinate existing guidance, facilitate global and regional collaboration, and develop a Global Strategy on Precision Medicine to guide equitable and context‑appropriate implementation. WHO stands ready to support Member States through tools such as a country maturity model for countries to self-assess capacity in implementing precision medicine depending on their context. In the immediate term WHO will map all existing guidance and frameworks and host extensive consultations with interest holders globally.By placing equity, inclusion and public value at the centre of precision medicine, the resolution reinforces WHO’s commitment to ensuring that scientific advances benefit all people, everywhere, and that no one is left behind in the next era of health innovation."By uniting people-centered healthcare with innovation, precision medicine has the potential to transform lives. This resolution helps ensure those advances serve the shared goal of health for all." Dr Sylvie Briand, Chief Scientist For further information please visit the Health Topic: Genomics
Report: Brighton pushing to sign defender in £11m deal
Brighton Target Costinha as Right Back Search IntensifiesBrighton & Hove Albion are advancing talks to sign Olympiacos right back Costinha, with The Athletic reporting that discussions are centred on ...
Trump's revenge politics comes back to haunt him
Trump's targeting of GOP foes is hurting his agenda on Capitol Hill.
Lawmakers target hospitals – and Atrium Health in particular
Legislation aims to increase oversight of hospital mergers, cap hospital CEO pay and add more accountability for hospital authorities like Atrium Health.
🥐 Target, Real Madrid; CR7 champion; comebacks... Friday's 5️⃣ stories
The football scene wakes up in turmoil both in the boardrooms and on international benches. The official announcement of a candidacy for the Real Madrid presidency opens a new institutional horizon at...
Popular weight loss drugs like Wegovy may also target arthritis inflammation
Researchers have discovered that the GLP-1 hormone targeted by drugs like Wegovy is present in very low amounts inside the joints of arthritis patients. That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss. Scientists say this could open the door to a completely new approach to arthritis treatment.
Report: NIH, NASA Restrict Co-Authoring With Foreign Scientists
The National Institutes of Health and the National Aeronautics and Space Administration are targeting collaborations between U.S. scientists and foreign researchers, Science reports.
Denver, Boulder prosecutors call congressional immigration probe ‘political theater’
Elected officials in Denver and Boulder are pushing back after the U.S. House Judiciary Committee opened an investigation into their immigration policies, as part of a broader probe targeting “sanctuary” jurisdictions nationwide. On May 20, U.S. Rep. Jim Jordan, R-Ohio, who chairs the House Judiciary Committee, issued letters to the district attorneys, sheriffs and police […]
Business owner speaks out after anti-Israeli graffiti vandalism
The owner says it's not the first time she has been targeted because of two Israeli flags in the windows.
Homeland Security’s Plan to Strong-Arm ‘Sanctuary’ Cities
DHS Secretary Markwayne Mullin told travel executives he may target airports in cities that don’t help ICE.
The world has fallen behind on health goals | Harvard T.H. Chan School of Public Health
Progress on the health targets in the United Nations’ 2015 Sustainable Development Goals has been too slow—and in some cases is backsliding.
Scientists discover hidden weakness shared by hundreds of cancer mutations
Scientists have unveiled a powerful new tool called PerturbFate that could change how researchers tackle diseases driven by huge numbers of genetic mutations, including cancer and Alzheimer’s. Instead of trying to target every faulty gene individually, the system tracks how different mutations reshape cells over time and identifies the hidden “control hubs” where those pathways converge.
007 First Light Targets 60 FPS Everywhere Except Series S, As IO Blames RAM And GPU Headroom For The Cutback
IO Interactive says 007 First Light targets 60 FPS on PS5, PS5 Pro, and Xbox Series X, while Series S is limited to 30 FPS due to RAM and GPU
Climate Standard Setter SBTi Pivots to Advisory Role as It Targets Growth
The Science Based Targets initiative has traditionally focused on validating emissions-reduction goals.
Legal expert unleashes on Spanberger's new executive order targeting ICE: 'Political theater'
Gov. Abigail Spanberger signs executive order citing concerns that Trump administration could use immigration enforcement to intimidate Virginia voters.
'MOP UP MICHIGAN' | Group targets utility spending, mystery money in MI politics with proposed ballot initiative
Gov. Polis signs prison bill targeting Colorado’s overcrowding crisis
Colorado Gov. Jared Polis on Tuesday signed a corrections bill that seeks to ease chronic overcrowding in state prisons by expanding earned‑time credits and launching a new working group to overhaul population management. Senate Bill 159 establishes a working group to make recommendations for how the Department of Corrections can reduce overcrowding in its facilities. […]
Gov. Polis signs prison reform bill targeting Colorado’s overcrowding crisis
Colorado Gov. Jared Polis on Tuesday signed a sweeping corrections bill that seeks to ease chronic overcrowding in state prisons by expanding earned‑time credits and launching a new working group to overhaul population management. Senate Bill 159, sponsored by Sens. Mike Weissman, D-Aurora, and Julie Gonzales, D-Denver, and Reps. Javier Mabrey, D-Denver, and Matthew Martinbez, […]
From Germany: Josko Gvardiol targets summer Manchester City exit
Croatian international defender Josko Gvardiol is reportedly considering a departure from the Etihad Stadium after just three seasons in England.Bundesliga heavyweights Bayern Munich are monitoring th...
Sabres Goalie Named Potential Trade Target For Division Rival
Could the Sabres deal goalie Devon Levi to one of their top rivals?
Why Rangers could target Mavrik Bourque this offseason
This is an extremely important offseason for the New York Rangers. After missing the Stanley Cup Playoffs two seasons in […]
San Diego attackers' hate manifesto targeted many groups, sought 'destruction of political system', sources s
An Anti-Defamation League analysis of the manifesto referenced "the great replacement theory," the belief that white people are being replaced in their countries by non-white immigrants.
Google Launches $100 Monthly AI Ultra Plan
New subscription targets developers and creators using Gemini
Mace targets Squad Dem with proposed constitutional ban on foreign-born lawmakers
Rep. Nancy Mace proposes expanding the natural-born citizen requirement beyond the presidency to Congress, federal judges and cabinet appointees.
American Bison Survived Extinction. Can They Survive Politics?
Trump’s latest public lands fight targets creatures central to Indigenous culture and American ecology and history.
Scientists found a hidden Alzheimer’s trigger and shut it down
A newly identified enzyme called IDOL could become a major new target in the fight against Alzheimer’s disease. Researchers found that removing it from neurons sharply reduced amyloid plaques and improved key brain processes linked to resilience and communication between cells. The discovery may lead to future treatments that go beyond slowing Alzheimer’s — potentially helping protect the brain from further decline.
Target notches much-needed win in first quarter of turnaround strategy
Target's first quarter crushed expectations, netting $25.4 billion in sales, as shoppers flocked to the retailer's renewed mix of trend and value.
Target’s comeback strategy is working
American shoppers are brushing off higher gas prices and finally spending money at Target again.
£52m Bundesliga star still an option for Liverpool
Nico Schlotterbeck Emerges as Ideal Long-Term Liverpool OptionLiverpool’s search for defensive stability may yet lead them back towards Liverpool FC target Nico Schlotterbeck, with the Borussia Dort...
NAACP launches campaign targeting college sports programs in Southern states over voting rights, students respond
Lewis Steele: Liverpool to sign ‘top winger’ this summer
Liverpool Target Elite Winger as Yan Diomande and Bradley Barcola Links GrowLiverpool are expected to prioritise the signing of a “top winger” this summer, according to Lewis Steele, with conversa...
Trump-backed Navy SEAL vet delivers major blow to Massie in fiery GOP primary
Trump targeted GOP critic Rep. Thomas Massie in Kentucky's record-breaking $32 million House primary, backing former Navy SEAL Ed Gallrein to unseat him.
Two AI-based science assistants succeed with drug-retargeting tasks
Both tools generate hypotheses; one goes on to analyze some of the data.
Vast Launches Satellite Bus Business Line
The commercial space station company announced this morning that it would start selling satellite buses, specifically targeting the low-cost, high-volume, high-power niche for missions from comms, to EO, to national-security programs.
In deep blue California, Dems find a villain toxic enough to rival Trump: The power company
Rising electricity prices have frustrated voters, creating a prime target for candidates.
Exclusive: Airbus targets 10% cost cuts over global uncertainty and supply snags
Europe's Airbus is telling thousands of staff to reduce spending by 10% as global uncertainty and supply chain problems continue to squeeze its core jetliner business, three industry sources said.
Trump targets Massie in explosive Kentucky showdown as six states hold high-stakes primaries
Six states hold primaries Tuesday testing President Trump's grip on the GOP, with high-profile races in Kentucky, Georgia, Alabama, Oregon, and Pennsylvania.
Trump targets GOP Rep. Massie in final hours of campaign
Trump targets Massie in latest political fight as MAGA holds strong
During a November news conference alongside survivors of Jeffrey Epstein, Rep. Thomas Massie, R-Ky.
Redistricting debate shifts to South Carolina as Republicans target Rep. Clyburn's seat
The Southern redistricting efforts come after a recent U.S. Supreme Court ruling that weakened Voting Rights Act protections for minority districts.
Target RWE and NoviSci Rebrand as Pedestal Health and Headwater Science
DURHAM, N.C., May 18, 2026--Target RWE and NoviSci, two leaders in evidence generation, today announced they will rebrand as Pedestal Health and Headwater Science. These two distinct companies will work to build a modern evidence-generation engine for life sciences organizations, navigating the most complex and consequential research challenges.
Redistricting debate shifts to South Carolina as Republicans seek clean sweep of House seats
GOP to target seat held by Jim Clyburn, the only Democrat among the state’s seven representatives in the House
Trump’s vendettas deliver, but at what cost to the GOP?
President Donald Trump is lining up new targets after felling yet another Republican critic in a retribution campaign that he finds deeply satisfying but that comes with widening political risks for his party.
British Takeovers Up 250% as Global Buyers Bypass Political Flux
Britain has been a go-to destination for international deal hunters. The value of M&A mergers targeting UK companies is up more than 250% this year to around $150 billion, according to data compiled by Bloomberg.
The Women’s Health Innovation Radar:
Advancing women’s health requires not only scientific progress, but an innovation ecosystem capable of translating discovery into evidence, technologies and scalable solutions that improve outcomes for women globally. Yet many high-impact conditions continue to receive insufficient targeted innovation. The Women’s Health Innovation Radar maps activity from research funding and scientific publications to clinical trials and product development across 10 high-impact conditions, highlighting where innovation is advancing and where critical gaps persist. It offers a foundation to guide research priorities, inform policy decisions and mobilize investment towards areas of unmet need, helping to ensure that scientific advances translate into meaningful impact for women worldwide.
The Women’s Health Innovation Radar:
Advancing women’s health requires not only scientific progress, but an innovation ecosystem capable of translating discovery into evidence, technologies and scalable solutions that improve outcomes for women globally. Yet many high-impact conditions continue to receive insufficient targeted innovation. The Women’s Health Innovation Radar maps activity from research funding and scientific publications to clinical trials and product development across 10 high-impact conditions, highlighting where innovation is advancing and where critical gaps persist. It offers a foundation to guide research priorities, inform policy decisions and mobilize investment towards areas of unmet need, helping to ensure that scientific advances translate into meaningful impact for women worldwide.
Trump targets political rivals ahead of midterms
Louisiana Senator Bill Cassidy, who’s been at odds with Trump, lost his primary this weekend. It comes as the president is targeting other political foes ahead of midterms, with another primary fight set for this week. NBC’s Julie Tsirkin reports.
[Report] WHO: Global health gains face threat of reversal
WHO published the World Health Statistics 2026 report showing the world is falling short on health targets, with progress uneven, slowing, and in some areas reversing.
Video: Cassidy Loses Primary After Drawing Trump’s Ire
Republican Senator Bill Cassidy lost his Louisiana primary on Saturday after President Trump targeted him for voting to impeach him in 2021. The two-term senator took veiled swipes at the president in his concession speech.
€100m Liverpool target may remain in Bundesliga
Yan Diomande Transfer Race Takes Fresh TwistLiverpool Target Faces Bayern ShadowYan Diomande has become the sort of name that turns recruitment meetings into longer conversations. At 19, with 13 goals...
Trump sent a message by targeting Bill Cassidy. In defeat, Cassidy delivered one back
Louisiana Republican Sen. Bill Cassidy wanted his reelection campaign to be about the “present and the future.” President Donald Trump had other plans. Cassidy became the first GOP senator to lose renomination in close to a decade, a remarkable downfall that shows again how Trump dominates the party. He signaled in his concession speech, without mentioning Trump, that he could spend the final months of his term being more of a thorn in Trump’s side – or at least more openly critical.
From leadership to succession, executive courses target wealthy families
Short business school programmes are helping scions prepare, moving into territory dominated by banks and advisers
Now What? With Carbon Pricing Eroded and Pipeline Politics Advancing, Here Are the Pathways for Climate Success
At the end of a whirlwind week of news on carbon pricing and electricity strategy, capping a madcap year of pretty much non-stop, dramatic change, the word across much of Canada’s climate and energy transition community is that climate policy in this country has been shredded. Eviscerated. Hit with a sledgehammer by policy rollbacks that have pushed the country’s 2050 net zero target “well out of reach”. That means it’s never been more important to look for the rays of hope and glimmers of possibility. To glimpse the seeds of the next set of strategies to get Canada’s climate pollution under control and the country into the accelerating global dash away from fossil fuels. And then, once we’ve spotted those possibilities, get on with the hard, day-to-day slog of trying to make them a reality. Nothing takes away from the frustration and the deep disappointment so many climate and energy hawks are expressing, the sense of betrayal by the author of Value(s) and the former UN special envoy for climate action and finance. But we knew two things as the week drew to a close. We’re looking at the world as it most definitely is. And we don’t get to give up finding the pathways to confront climate change and deliver faster, deeper carbon cuts that leave no one else behind. So really, the first question we all have to ask ourselves is: What’s next? Subscribe All the Oxygen in the Room The outpouring of anger and grief over the carbon pricing deal between Prime Minister Mark Carney and Alberta Premier Danielle Smith has been absolutely understandable. So much of the climate community poured years, more than a decade, into dragging the current federal pricing regime across the finish line, then defending it from a deluge of three-syllable rhymes after the Trudeau government proved utterly incapable of delivering its own message. The policy foisted on us by neo-classical economists took up all the oxygen in the room, burned through years of climate response time that we won’t get back, while cornering climate hawks into the position that the best response to the crisis of our lifetimes is a new tax…in an era of historic anti-tax sentiment. I mean, really—what could possibly have gone wrong? Against that history, let’s appreciate columnist Max Fawcett’s point that even a modest carbon pricing agreement with a government as off-the-wall libertarian/conspiracist as Danielle Smith’s—those adjectives are mine, not Max’s—is a win worth savouring (as long as Smith keeps her promises for a change). But part of living in the world as it is (no, I’m not letting that go) is to be clear-headed about what we can and can’t control. And one thing we get to decide, after seeing this week’s carbon price festivities take up all the oxygen yet again, is whether we want to keep letting that happen. Particularly when success down that road depends on a factor that no one with a climate agenda can control or influence—a provincial carbon pricing mechanism that has been manipulated and eroded beyond its lowest possible denominator. Thankfully, that’s not the way it has to go. Not when we have so many other powerful, practical tools at our disposal, including the ones still available to us through this abominable Memorandum of Understanding (MOU) between Canada and Alberta. Tools In Our Toolbox When I started roughing out this list, I didn’t expect it to grow to nearly a dozen bullet points. It’s probably still incomplete. Some of the greatest hits in today’s climate solutions toolbox include: • No Carbon Capture, No Pipeline: On Friday, Prime Minister Mark Carney explicitly stated that there’s been no change to the MOU provision that there will be no West Coast pipeline without an industry commitment to build its massive, $16.5-billion carbon capture and storage (CCUS) hub in Northern Alberta, and vice versa. The two megaprojects were joined at the hip when the MOU was signed Nov. 27, and the implementation agreement this week affirmed that they still are. A parade of independent analysts have spent years pointing to the economic and technical flaws in CCUS, while the industry kept postponing its investment decision until it could arm-twist the government for more “clarity” (by which it meant even more lavish taxpayer subsidies) on the project. Now the industry itself is running away from the CCUS hub and insisting the pipeline should proceed without it, but Carney doesn’t seem to be budging from a central tenet of the MOU to which Smith has signed on. • No Subsidies, No Investors: Climate analysts and advocates have quite rightly been hammering away at Carney and his team, insisting that any new capacity the industry wants to build must proceed without new subsidies. The government has responded with a growing collection of funding and financing mechanisms for the very wide menu of industrial development and nation-building projects they say they want to take on, and that menu always includes fossil fuel infrastructure. But it’s hard to see how even the combined fiscal clout of the federal and supportive provincial governments will deliver the financial backing private investors would need when the business case for new fossil fuel development is evaporating before their eyes. Particularly when… • No Market, No Demand, No Investors: As our friend Markham Hislop at Energi Media (our apparently sleepless friend, given the massive volume of great material he’s been churning out) points out this morning, the biggest vulnerability in any pipeline deal is the assumption that Asian buyers will want the oil or liquefied natural ga that our fossil industry is so keen to send them. Hislop writes in part: Ottawa and Alberta are effectively betting that countries like China and India will continue increasing oil imports for decades as their economies grow and energy consumption rises. That assumption underpins the entire economic rationale for expanding oil sands production and building billions of dollars in new export infrastructure. But Asian energy systems are changing rapidly… China, India, South Korea, and other major hydrocarbon importers are now investing hundreds of billions of dollars into electricity systems built around wind, solar, batteries, nuclear, hydro, and expanded transmission infrastructure. Domestic “energy sovereignty” is increasingly replacing the old energy-security model based on stable oil and gas imports. Those investments are expected to sharply slow oil demand growth and eventually reverse it, even as overall energy consumption continues rising. There are also refining constraints. Many Asian refineries and petrochemical complexes are already optimized to process discounted heavy crude from the Middle East and Latin America. That raises serious questions about how much additional Canadian bitumen Asian markets can absorb at profitable prices. Small wonder that there’s still no private sector investor for the project, despite Smith’s government desperately beating the bushes to put together a deal. For now, Alberta is acting as proponent and covering early start-up costs for a pitch to the federal Major Projects Office, which could actually turn into the next tough hurdle for Smith and her pipeline to jump. • Canada Day Looms: How ironic that Canada’s birthday this year could become a major chokepoint for the provincial premier who’s been working so diligently to tear the country apart! The July 1 target date for Alberta’s pipeline proposal is baked into the MOU, was reaffirmed by the implementation plan, but it hadn’t dawned on me that it cuts both ways. As one very smart colleague wrote in an email yesterday, “they’ve thrown the ball into Alberta’s court to get the project proposal on the table really quickly and to have to do a whole pile of work to put together a massive, complicated project that would typically take years to assemble, and they’ve given them weeks to do it.” That makes July 1 a looming deadline that Smith won’t be able to run away from politically, especially with the separatists in her party and her caucus breathing down her neck. (See previous ref to off-the-wall.) But if Alberta comes in with a sloppy, incomplete submission, even after Carney bent over backwards to simplify the application process and the rules that govern it, it may be harder for the province or the industry to blame Ottawa and insist on the faster process they claim their investors are demanding. (Oh, wait—which investors would those be??) • We’ll See You In Court (Then We’ll See You Again): If Carney did cave, that would be just one more reason for Indigenous and other affected communities to take the government and the process to court—Just as Alberta First Nations did, successfully, in response to Smith’s half-baked separation referendum. Veterans of the Harper era have been warning that a shoddy process around fossil fuel infrastructure or other major projects will be a recipe for the very delays that process seeks to avoid. And now more than ever, with renewable energy and energy storage eating fossil fuels’ lunch in import markets around the world, a delayed pipeline or LNG terminal may be as good as a cancelled one. • Charged Up, Ready to Go: With its goal of doubling Canada’s electricity supply to meet a doubling of demand by 2050, the national electricity strategy that Carney unveiled Thursday has a lot to like. With its explicit language about speeding the shift from fuels to more efficient and affordable electricity, global investment and deployment patterns that already favour that shift, an emerging bidirectional power grid, the role of front-line options like rooftop solar and heat pumps, the emergence of electric vehicles as behind-the-meter energy storage, and the domestic jobs and manufacturing to make it all happen, the document doubles down on the essential cornerstone of a faster shift off fossil fuels. The strategy envisions a more prominent role for gas and nuclear power. But some of those provisions were already in the Clean Electricity Regulations that climate hawks are now fighting so hard to defend, inserted as a compromise in a futile attempt to mollify the industry and its political representatives in Alberta and Saskatchewan. But once again, gas will be a tougher sell when it’s more expensive and now so much more unpredictable than the clean alternatives. The new nuclear technologies are still speculative and deeply vulnerable to cost overruns. Increasingly, utilities, developers, and investors know it. Carney declared Thursday that “it doesn’t do us good to be sitting in court all the time with provinces. It doesn’t do us good to be talking past each other. What does do us good is to come together with specific projects.” There are no guarantees, but so much of the language and narrative-building in the electricity strategy suggests the lion’s share of those projects will be renewable. • The Party Has Already Started: The electricity strategy only rarely digs down to specific projects, but provinces representing three-quarters of Canada’s population are already embracing a faster transition. Hydro-Québec is working on a 10-year, $185-billion renewable energy and grid buildout by 2035. Ontario recently brought 10 provinces and territories together in a National Energy Corridor Agreement to boost interprovincial and -territorial transmission infrastructure. And the MOU implementation agreement commits Alberta to facilitate investment in renewable energy projects, a big step back from its continuing, punitive restrictions on renewables development. The electricity strategy envisions much of the financing and infrastructure that will be needed to pull those advances together into an integrated whole. • Delivering on Affordability: The MOU implementation plan has little or nothing to say about affordability (are you surprised?), but the electricity strategy does, with a top-line pledge to reduce home energy costs for seven out of 10 Canadian households by 2050, a total saving of $15 billion across the board. It’s just a start, but it puts affordability on the government’s narrative map. If they’re serious and deliberate about patching together a least-cost energy strategy, it’ll have little if any room for oil, gas, or nuclear—not with powerful evidence, for example, that electricity prices are higher when those prices are set by gas. • Smith Proves that Canada Works: By signing a deal that makes it harder to claim the federal government is blocking a new pipeline, Smith has helped prove Carney’s constant anti-separatist refrain that “Canada works”—incurring the rage, no doubt, of her own political base. Canada also needs to work for anyone who depends on a clean environment, healthy and thriving ecosystems, and safe, stable climate. But with Smith and her separatist constituents setting up as a fifth column for annexation by Donald Trump’s United States, let’s set aside any notion that 51st state status for Canada is a recipe for anything other than climate disaster (and so much else). Resisting and withstanding Trump (just 170 more sleeps until mid-term elections, which is a damn sight better than the 730 we started with) doesn’t mean a free pass for a pipeline, but we can still appreciate it that keeping Canada whole and sovereign is still Carney’s Job One. • The Words Not Spoken: Apart from a commitment to export a million barrels of “low-emission” Alberta bitumen per day (memo to Smith and Carney: You realize that that’s less than the industry is already exporting??), the MOU implementation plan says nothing about the international trade and economic sovereignty deals that Carney has been travelling the world to negotiate. It didn’t have to. Carney doesn’t need permission from Danielle Smith, her American enablers, or her separatist allies to continue building the alliances that will ratchet down our economic dependency on our unstable, unreliable neighbour to the south. But every connection he builds with countries outside North America helps align our economy and our future with a faster shift off fossil fuels. Little if any of this was on our bingo cards a year or two ago. But it’s the pathway that has opened up to us. And if it gives Canada any climate or energy gains at all in an era still dominated by Trump and his increasingly ridiculous tariffs, his loutish trade negotiations and his continuing annexation threats, we have to take the wins. Not least because they’ll be the point of departure for what we can achieve in 2027, 2029, and beyond, as Trump’s grip and this era begin to loosen and then fade. What is Carney Doing? If this line of thought is right—and it’s a possibility, not a prediction—it means that Carney’s actions and decisions are largely about buying time. Time for Trump’s power to wane. Time for Alberta’s separatist/conspiracist virus to spread, mutate, die out, or at least die back, with help from a vaccine of federal steadiness and calm (appropriate enough, for a movement populated largely by vaccine deniers) that no conspiracy theory can dismiss. And time for the government’s trade and investment agenda to deliver results—even knowing that some of those results will bring impacts that front-line communities will not and should not accept. In the immediate moment, none of this changes the way the wider climate community has to respond, from campaigners to investors to front-line practitioners. All of our voices are still essential. But those voices will be stronger and more confident if we have a clearer sense of the brutal game we’ve been pulled into, and a plausible path (or two it three) for playing it to the win we need. This conversation also underscores our biggest task for the remaining years of what was supposed to be the “decisive” decade for climate response: if we can shift the energy narrative in Canada, make it a mainstream view that the country’s preoccupation with oil and gas has us falling farther behind a changing world, we’ll see far better results in the 2030s and beyond. For many veteran climate advocates, taking on that part of the fight will begin with recognizing that most of our friends and family, neighbours and colleagues already understand that climate change is real and right in front of us: they’re looking away and staying silent because they don’t have what climate communicator Katharine Hayhoe calls “efficacy”. As Hayhoe recently pointed out in a feature interview with The Energy Mix, it amounts to science denial to keep hammering away at the dire news about global warming without also helping audiences understand what they can do about it, with multiple studies telling us why that won’t work. Far better to open those conversations with the dominant crises like energy security, food security, emergency preparedness and business continuity, affordability, and financial security that have knocked climate change far lower on the list of public priorities, and will likely keep it there. We Knew This Would Happen Climate hawks have always known this day would come. For decades, we warned that everyone had to pay attention to climate change right now, because it would be much tougher to respond once the crisis itself started affecting our daily lives. We were right, and here we are. But now, thanks to decades of hard work, communities and countries have an alternative to doubling down on fossil fuels. “In 10 years everyone will have ‘always known’ that solar and batteries were going to win,” Morgan Solar Executive Chair Mike Andrade writes on LinkedIn. With the disruption in the Strait of Hormuz roiling energy priorities around the world, Canada and the United States are among the shrinking number of countries that are still very keen on fossil fuel development. Understanding that gap is a first, essential step in spotting the opportunities ahead, and averting the deep economic as well as environmental and social risk we face if we don’t seize them. Thanks for reading The Energy Mix Weekender! Subscribe for free to receive new posts and support our work. Subscribe Mitchell Beer traces his background in renewable energy and energy efficiency back to 1977, in climate change to 1997. Now he and the rest of the Energy Mix team scan 1,200 news headlines a week to pull together The Energy Mix and The Energy Mix Weekender. Chart of the Week BYD Eyes 20 Dealership Locations After Canada Greenlights Chinese EV Imports ‘Sledgehammer’ Carbon Price Deal Boosts Emissions by 230Mt, Aims for Fall 2027 Pipeline Approval ‘Worse Than Harper’: Regulatory Rollback Would Stop Canada from Assessing Project Impacts, Critics Warn Electricity Strategy Aims for Doubling by 2050, Allows ‘Flexibility’ for Gas Power Plants Opposition Mounts as O’Leary’s Data Centre Approved in Drought-Stricken Utah Diluted Carbon Price Misses ‘Reality of the World We’re In’, Could Impede Diversified Trade: Climate Institute $200B in Clean Energy Investment Will Need On-Time Delivery, Reliable Policies, Trade Association Says ‘Sovereign Pipeline’: CEO Pitches to Keep Trans Mountain in Government Hands What a Supercharged El Niño Could Mean for Canada Canada’s future is electric, and here’s how a power grid superhighway would get us there (Toronto Star) The Perilous Waters of Hecate Strait (Globe and Mail) Saudi Aramco profits jump despite conflict in Middle East (The Guardian) Farmers confront rising cost of fertilizer and fuel as spring seeding under way (Canadian Broadcasting Corporation) Clarkson forecasts 24% decline in offshore oil, gas capital expenditures (Oil & Gas Journal) Pipe Dreams: How Oil and Gas Fail to Deliver Economic Development in Africa (Oil Change International) Developing countries must hold the pen to script the fossil fuel transition (Climate Home News) Iran war threatens the dream of a post-oil economy in the Gulf (Washington Post) U.S. Oil, Gas Work Force Hits Lowest Level Since 2022 (Rigzone) Why Polestar Is Doubling Down on Net Zero as Rivals Pull Back on EVs (Bloomberg) Why this Michigan utility plans to sell its hydro dams for $13 (E&E News/Politico) Levees can no longer save New Orleans (Vox)
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