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Exclusive: Yuzu Health raises $35M for health benefits
As health insurance costs are rising, so is demand for different types of plans and coverage.
Vikings' J.J. McCarthy gets QB1 confidence boost from former teammate
McCarthy's teammate has all the confidence that he'll prove people wrong.
OKC Thunder, FanDuel Sports Network will part ways after 2025-26 NBA regular season
The OKC Thunder will be looking for a new broadcast home after FanDuel Sports Network ceases operations at the end of the 2025-26 NBA regular season.
Can Hawaiʻi Deliver All Of America From Citizens United?
A state Senate bill proposes a novel approach that one legal expert says would make the controversial national campaign finance law irrelevant in the islands.
Georgia football offers QB after 49 touchdown season
The Georgia Bulldogs have offered a scholarship to one of the best quarterback prospects in the class of 2028
Take-Two laid off the head its AI division and an undisclosed number of staff
A former head of AI at game publisher Take-Two has announced that he and several members of his staff have been laid off.
Maternal health crisis: Why Massachusetts is losing its edge
Despite years of investment by the state, maternal health disparities continue to grow.
Kirk Cousins getting paid by Raiders: How QB has cashed in to become one of NFL's richest players
Only two players in NFL history have made more money than Cousins and they are both locks for the Pro Football Hall of Fame.
Cowboys news: What Mike McCarthy said about Brian Schottenheimer
Check out today’s latest and greatest news surrounding America’s team!
Maui Mental Health Providers Face Stress And Uncertainty About State Jobs
Staff at a state-run clinic serving wildfire survivors in Hawai‘i have waited months for permanent jobs. Instead, they got another temporary contract.
What Raiders’ Kirk Cousins deal means for Fernando Mendoza, Aaron Rodgers and NFL QB market
Nuggets Desperately Need “Playoff Jamal Murray” to Win Another Ring
In the summer of 2023, the Denver Nuggets were on top of the NBA world, defeating the Miami Heat to claim the Larry O’Brien Trophy. Denver took down Anthony Edwards‘ Timberwolves, Kevin Durant‘s Suns, and LeBron James‘ Lakers en route to its first championship in franchise history. Three-time NBA MVP Nikola Jokić took home Finals MVP, […] The post Nuggets Desperately Need “Playoff Jamal Murray” to Win Another Ring appeared first on The Lead.
New study shows that SKYPAC generated over $16 million in 2025
The report highlights SKYPAC’s role as a destination that attracts visitors who spend money throughout the community.
Hey, MLB! Stop scheduling games in northern cities in March
March should be for basketball “Madness,” not baseball madness.
Chinese satellite with robotic 'octopus arm' passes key refueling test in orbit — making longer-lived space assets more likely
The experimental Hukeda-2 satellite and its highly flexible robotic arm have passed a major refuelling test in low Earth orbit. The demonstration is the latest step toward China significantly expanding the longevity of its spacecraft.
QB Kirk Cousins reportedly signs with Raiders ahead of team likely taking Fernando Mendoza with No. 1 pick
2026 NFL seven-round mock draft: Steelers, Jets, Cardinals among teams targeting QBs as 11 come off the board
From the No. 1 overall pick to Mr. Irrelevant, here's how every team builds its 2026 class.
Kirk Cousins agrees to sign with Raiders
While Las Vegas is expected to select Fernando Mendoza at No. 1 overall, Cousins gives the club a veteran option at QB.
Cleveland Browns NFL Draft Profile: QB Diego Pavia, Vanderbilt
The dynamic Commodore is equal parts of two familiar former Browns QBs. Would the team really sign back up for that?
Fernando Mendoza's pro day confirms his QB1 status for 2026: Here's how he stacks up to past top QB prospects
Size, arm talent and composure were on display in a pro day that confirmed his status as the next No. 1 overall pick.
Texas A&M QB Marcel Reed discusses Aggies' spring football progress
Texas A&M quarterback Marcel Reed discussed his progress and the Aggies' spring football season on the SEC Network.
5 Takeaways From Trump’s Address on Iran
President Trump did not define a clear path out of the conflict, which he estimated would end within three weeks.
Virginia Tech football: James Franklin hypes freshman quarterback’s ‘unbelievable’ performance
James Franklin shouts out freshman QB’s ‘unbelievable’ performance
'The Masked Singer' season 14 winner revealed in finale as 4 celebs unmasked
'The Masked Singer' reveals its season 14 winner as four celebs get unmasked as Galaxy Girl, Pugcasso, Cat Witch, and Crane in super-sized finale.
Cleveland Browns NFL Draft Profile: QB Cade Klubnik, Clemson
Cleveland’s QB room likely already has enough backups without adding another one in the draft.
FishBait Solutions rebrands as Pivotal Sports & Entertainment
Some 18 years after is after its founding by Rick Jones as FishBait Marketing, the boutique agency known as fishboat Solutions since 2021, is rebranding to Pivotal Sports & Entertainment.
Former Detroit Lions QB Hendon Hooker signs with Titans
Former Detroit Lions quarterback Hendon Hooker is signing with and heading to the Tennessee Titans.
Microsoft Warns of WhatsApp-Delivered VBS Malware Hijacking Windows via UAC Bypass
WhatsApp VBS campaign began February 2026, abusing AWS and UAC bypass to gain persistent remote access.
How RFK Jr.’s MAHA agenda keeps hitting roadblocks
HHS Secretary Robert F. Kennedy Jr. over the last several months has suffered a series of setbacks that have sapped his influence within the GOP and left him diminished within the Trump administration.
How to watch NASA's historic Artemis II launch for the moon
NASA's Artemis II mission is set to take four astronauts on a record-breaking spaceflight around the moon, bringing humans farther into space than ever before. Here's how to watch it.
Serie A winger linked with Liverpool as Salah replacement
Juventus Transfer Plans: Premier League Pressure Mounts as Champions League Stakes RiseChampions League Race Shapes Juventus FutureJuventus stand at a familiar crossroads, one shaped as much by financ...
Iraq defeat Bolivia 2-1 to qualify for FIFA World Cup 2026
Goals from Ali Al-Hamadi and Aymen Hussein send Iraq to their first FIFA World Cup since 1986.
Trump receives warm reception at the Kennedy Center after transforming the arts institution
President Donald Trump finally got the Kennedy Center reception he’s always wanted.
Chiefs HC gives update on Patrick Mahomes' injury recovery
Chiefs HC Andy Reid spoke to reporters at the annual league meeting on March 31 and gave an update on QB Patrick Mahomes' ACL recovery.
Apple AirPods Max 2 review
Maximum luxury, but should Apple have strayed from the formula more?
Steelers 2026 NFL Draft scouting report: QB Cade Klubnik
As the Pittsburgh Steelers prepare for the 2026 NFL Draft, here is a scouting report for quarterback Cade Klubnik of Clemson.
Oregon CB confirms various pre-draft meetings with Raiders
A University of Oregon cornerback recently confirmed multiple pre-draft meetings with the Las Vegas Raiders.
New Zealand Business Sentiment Hits Lowest Since 2024 Recession
New Zealand business sentiment slumped in March to the lowest since mid-2024 when the economy was in recession as the Middle East conflict hits the outlook for earnings and investment.
Some are celebrating, but World of Warcraft's move away from the "Horde" and "Alliance" faction split will be seen as a historic mistake
Not only does it undermine decades of lore and world building, but player identity is how you reach your audience when they're *not* gaming. WoW's iconic faction split is under threat, and that's a bad thing actually.
DOJ whistleblower complains to Congress that internal watchdog isn’t doing its job
A former federal immigration prosecutor and whistleblower who has taken issue with Trump administration leadership has now gone to Capitol Hill, saying the internal watchdog offices of the Justice Department are doing nothing to investigate his and other complaints.
Predicting Falcons QB battle as Kevin Stefanski discusses expectations for Tua Tagovailoa, Michael Penix Jr.
Let's take the temperature of the upcoming competition in Atlanta.
2026 NFL three-round mock draft: Steelers target high-upside WR, then trade back into Round 1 for QB
Team needs have become much clearer after pro days.
In The Lab: Astros Starting Pitching WAR Projections
What can we expect from the Astros rotation this season?
To Keep Climate Science Alive, U.S. Researchers Are Speaking in Code
Words considered "woke" are vanishing from research proposals. Grist tracked the changes.
Former Bears QB made UFL history in Renegades debut
Former Bears quarterback Austin Reed made UFL history in his first game with the Renegades.
Browns' frontrunner at QB revealed by NFL insider Mike Garafolo
Who will start at quarterback for the Browns in 2026? One NFL insider thinks he knows who the current frontrunner is...
Cleveland Browns NFL Draft Profile: QB Garrett Nussmeier, LSU
What to make of Nussmeier’s NFL potential? And are the Browns in a position to risk finding out?
NBA playoff picture March 29: All of the scenarios and stakes for postseason contenders down the stretch run
Meet Leigh Cuen, The Tennessean's new music editor
Veteran journalist Leigh Cuen joins The Tennesseean as music editor.
How Jaxson Dart's presence has changed everything for NY Giants
A year ago, the Giants were in the middle of a desperate search for their franchise QB. Jaxson Dart has completely altered the narrative.
UEFA confirm Champions League semi-final details
UEFA have confirmed the details for the Champions League semi-finals, with Arsenal potentially in line for a trip to Spain if they can make it past Sporting CP.Photo by Marco Luzzani/Getty ImagesUEFA ...
And then Jamal Murray had a 31-point, 14-assist …
And then Jamal Murray had a 31-point, 14-assist …
New York Jets Flight Connections 03/28/26
Happy Saturday, Jets fans! Below are your links to kick off this weekend as we keep cruising toward the 2026 NFL Draft. NY Jets – Where Have the Jets Improved their Roster Most this Offseason? Jack Bell – Jets QB Geno Smith: Aaron Glenn is a ‘Special Coach’ Jack Bell – At No. 2 Overall […]
MAGA’s eruption has so far kept Trump from endorsing in key Senate race
President Donald Trump seemed set to endorse Sen. John Cornyn in the Texas Republican primary runoff. But strong opposition from MAGA activists forestalled that.
Royals fall to Atlanta, 6-0
This was probably not the best ball the Royals will play this year.
How important is QB1 in the NFL Draft?
Is Ty Simpson QB1? Why situation may matter more than rankings in the NFL Draft.
NBA news, live updates: League proposes new anti-tanking ideas; Friday's playoff scenarios
87-year-old planetarium projector still dazzles visitors at Springfield Science Museum
The device is not only a technological marvel, but could easily be an exhibit in the very museum where it remains in operation.
UConn football hopefuls work out on Husky Pro Day
After recording back-to-back nine-win seasons, UConn has a number of former players vying for a chance at the NFL or other pro leagues. On Tuesday, the players had the opportunity to showcase their skills in front of 27 NFL scouts at UConn’s 2026 Pro Day. The group included the following numbers at each position: QB: […]
Did Scientists Just Detect an Exploding Black Hole?
An underwater observatory recently detected a startlingly energetic cosmic neutrino. One possible cause involves a phenomenon that so far exists only in theory.
Jordan Love gifts cleats to local youth sports teams
Packers QB Jordan Love met with four local youth sports teams to gift them new cleats ahead of their upcoming seasons as a part of his foundation's '10ve for Cleats' campaign.
WhatsApp rolls out updates including multiple accounts for iOS
WhatsApp shared multiple quality of life updates coming to its messaging platform starting today.
AdeptiCon Preview 2026 – A new Lumineth Realm-lords warband breezes into Warhammer Underworlds
Awesome aelves and their adorable vulpine spirit revealed.
James Talarico Responds With ‘Love’ To Hegseth Pastor’s Criticism
James Talarico, the Democratic nominee for Senate in Texas, said, “You may pray for my death, Pastor, but I still love you.” The pastor said he was calling for Mr. Talarico’s religious conversion.
NSF initiative aims to make every American worker, business and community AI-ready
The U.S. National Science Foundation announced a new funding opportunity as part of an effort to enable all Americans to understand, apply and create with artificial intelligence. The NSF TechAccess…
EQB welcomes Daniel Rethazy as EVP, Personal Banking, adding top banking talent to reignite core business growth and execute on transformation
EQB Inc. (TSX: EQB) today announces Daniel Rethazy's appointment as Executive Vice President, Personal Banking. Mr. Rethazy brings deep experience in Canadian Banking to EQB that will accelerate momentum and unlock a new era of growth for the company's Personal Banking franchise, delivering a more competitive and rewarding banking experience, and a stronger and more resilient banking industry for all Canadians.
DJ Lagway leaves Florida drama behind him, rewriting his story at Baylor
DJ Lagway was No. 1 QB in his recruiting class. But self-induced isolation and a run of injuries derailed Florida career. Baylor is a fresh start.
Fox Sports Host weighs in on the Chiefs acquiring QB Justin Fields
During a recent media appearance, Fox Sports Host Nick Wright weighed in on the Kansas City Chiefs acquiring quarterback Justin Fields | @EdEastonJr
Falcons introduce quarterback Tua Tagovailoa
Watch: Falcons QB Tua Tagovailoa introduced in virtual press conference
Joe Flacco returning to Bengals: 41-year-old QB set for 19th NFL season in 2026
Flacco is coming off his first Pro Bowl selection.
Mr. Tire employee arrested for twice setting fires at the business: Solon Police Blotter
Also in this week's blotter, the driver of a Jeep SUV would not stop for Solon police, who were attempting to cite him for an expired license plate.
Prisco's 2026 NFL mock draft 1.0: Four of top five picks on defensive side, Browns select QB
Teams at top of the draft opt for pass rush over offense.
Live Science Today: Earth hits record energy imbalance, Hawaii floods and NASA prepares for Artemis II launch
Monday, March 23, 2026: Your daily roundup of the biggest science stories making headlines.
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns
Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.
Incredible offer signals Liverpool are all-in on Rio Ngumoha
An incredible offer of a player signals a real intent from Liverpool to go all-in on teenager Rio Ngumoha.Are Liverpool about to go all-in on Rio Ngumoha? They’ve been reluctant to do so this season...
UFL team signs former Alabama high school, Crimson Tide QB
The Thompson High School alumnus had been scheduled to play in the Indoor Football League on Sunday.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
NFL Network: What's next for Bills QB Josh Allen? (video)
NFL Network roundtable looks ahead to Josh Allen and the Bills in 2026.
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms
The Republican National Committee wants to toss ballots arriving after Election Day. Critics say thousands of votes — a majority cast by Democrats — are at stake.
Election in Slovenia Will Test Europe’s Political Mood
The center-left government is being challenged by a right-wing populist accused of launching a smear campaign in the final days of a close race.
Marc Abrahams, founder of the satirical Ig Nobel Prizes: ‘Scientists in the US are very angry. People are waking up’
The awards are moving to Switzerland, because their founder believes he can no longer guarantee the laureates’ safety in the United States
Warriors' Stephen Curry set for major checkpoint in injury recovery
According to Steve Kerr, Golden State Warriors star, Stephen Curry will participated in a scrimmage on Sunday, March 22.
'That's why there's 9 billion of us and not 9 billion of some other primate': Why our ability to adapt is humanity's 'superpower'
Live Science spoke with Herman Pontzer, an evolutionary anthropologist and author of the book "Adaptable," about the science of human diversity.
In Opening Day preview, Mariners thrash Guardians, 20-8
Mariners smoke six homers en route to big win; Cole Young goes yard twice and Dominic Canzone hits a grand slam
Bengals hold top-30 visit with Rutgers QB Athan Kaliakmanis
Cincinnati wants a promising developmental quarterback behind Joe Burrow, and they had a visit with one recently.
More Subnautica 2 legal trouble brewing amid claims Krafton "intentionally leaked" May release without consulting reinstated CEO
Lawyers for Subnautica 2 studio's newly reinstated CEO are reportedly pushing for Krafton to be found in contempt of court after it "leaked" a May release.
Belkin Charging Case Pro for Switch 2 review: A more elegant solution
The pro version of Belkin's Switch 2 charging case is a more sophisticated and versatile power solution. But it’s also more expensive, so unless you're comfortable shelling out an extra $30 for the same basic features, you're probably better off sticking with the non-pro option.
InSo brings fine dining, nightlife entertainment to Las Colinas
InSo is an upscale Southeast Asian fusion restaurant that turns into a lively nightspot.
Steelers await Aaron Rodgers decision as NFL draft nears
Ben Roethlisberger weighs in as uncertainty surrounds Pittsburgh’s QB plan, with new weapons adding pressure for clarity before the 2026 NFL Draft.
Chargers depth chart: Where roster stands after several additions
Here is the Los Angeles Chargers' updated roster after several signings, re-signings, and departures.
No. 16 Siena nearly upsets No. 1 Duke in NCAA tournament while making only 1 sub ... for 2 seconds
Latest Vikings QB move a red flag for J.J. McCarthy
J.J. will have his work cut out this offseason.
Mullin addresses temper, ‘secret’ trip at DHS hearing
The confirmation hearing became combative between Mullin and Sen. Rand Paul