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Former STC Dual Credit Student Joins Computer Science Faculty
Texas Border Business By Joey Gomez McALLEN, Texas – South Texas College’s newest Computer Information Technologies (CIT) faculty member, Ramiro Santos believes he has come full circle. Not long ago, Santos was a dual credit student from PSJA Southwest Early College High School, who turned to STC faculty for guidance as he discovered a passion for […]
Business owners near the University of Cincinnati push back on street closures meant to curb violence
Business owners in Cincinnati’s CUF neighborhood near the University of Cincinnati say evening street closures put in place following a series of shootings are hurting their bottom lines.
James Talarico says Ken Paxton is "lying to the people of Texas" with AI ad that puts "words in my mouth"
Youth sports become big business, putting stress on families
American youth sports have become a 40 billion dollar business. But youth travel sports also come with increasing costs and challenges and parents are bearing the costs..
Youth sports become big business, putting stress on families
American youth sports have become a 40 billion dollar business. But youth travel sports also come with increasing costs and challenges and parents are bearing the costs..
The Center for Health and Human Rights submits an input to the United Nations on mobilizing public resources to finance sustainable development
The Center for Health and Human Rights (CHHR) of the O’Neill Institute for National and Global Health Law at Georgetown Law submitted an input on August 20 in response to
Republicans gather in Dallas for two-day midterm convention billed as 'Trump-a-Palooza'
The highly unusual midterm convention puts President Donald Trump at the center of this fall’s midterm elections — whether the candidates running like it or not.
‘Few new ideas’: What Trump’s feckless diplomacy tells Putin
Trump’s envoys in Ukraine seem desperate while Germany’s right surges.
The Latest: Republicans gathering for 'Trump-a-palooza' convention in Dallas
Republicans are gathering in Dallas on Wednesday for a highly unusual midterm convention, a “Trump-a-Palooza” that will put Trump at the center of this fall’s midterm elections — whether the
Apple Unveils A20 Pro as First 2nm Smartphone Chip
Apple today revealed the A20 Pro chip in the iPhone 18 Pro and iPhone 18 Pro Max, built on a brand new architecture using 2nm process technology. Apple described the A20 Pro as "an exceptional chip that sets a new bar for mobile computing". The chip has a 6-core CPU design with two new super cores that Apple says are up to 20% faster, calling them "desktop class" and "the fastest in any smartphone," alongside four new efficiency cores.
Racing legend Jack Roush to auction off iconic cars, personal hot rods
Legendary engineering innovator and motorsports icon Jack Roush is putting cars from his museum collection up for auction for the first time.
Jake Paul Teases Michael Page Signing for MVP MMA
Fight promoter Jake Paul teased a potential signing of former UFC fighter Michael Page to the MVP MMA roster.Page completed his six-fight UFC contract with a unanimous decision win over Nursulton Ruziboev at UFC Paris. However, he was heavily criticized by fans for putting on another boring fight, which was not the first time he’s […] The post Jake Paul Teases Michael Page Signing for MVP MMA appeared first on HEAVY.
FSU computer scientist earns NSF CAREER Award for data compression research
A Florida State University computer scientist has earned one of the most prestigious awards available to early career faculty for developing
TCU Sinks in Big 12 Rankings After Ugly UNC Loss
TCU tumbles near the bottom of the Big 12 after a 15-10 loss to North Carolina, putting pressure on Sonny Dykes and the Horned Frogs to respond fast.
At 9/11 tribute, Trump adds new claim to his disputed role after attack
There is no evidence backing up President Donald Trump’s claim about firefighters carrying him to safety after the attack. It's part of his evolving — and often disputed — account of his 9/11 actions.
The Latest: Republicans gathering for 'Trump-a-palooza' convention in Dallas
Republicans are gathering in Dallas on Wednesday for a highly unusual midterm convention, a “Trump-a-Palooza” that will put Trump at the center of this fall’s midterm elections — whether the
NOAA is putting commercial fishing ahead of conservation
Critics say the new agenda could weaken science-based rules and marine protections.
Dodgers Stay Put in Latest Power Rankings
The Los Angeles Dodgers have not budged in Bleacher Report's latest power rankings.
Will it kill off humanity? Computer scientists and politicians wrestle with risks of AI
Alarming warnings from industry insiders increase pressure for curbs on artificial superintelligence
Will it kill off humanity? Computer scientists and politicians wrestle with risks of AI
Alarming warnings from industry insiders increase pressure for curbs on artificial superintelligence
Save 40% on Autodesk’s Media and Entertainment Collection — thousands of dollars worth of software in a single bundle
Big savings for big ideas
Boston Bruins lock up young center Fraser Minten
The Boston Bruins believe they have a rising star in Fraser Minten and they put that belief in action by signing the center to a seven-year, $50.4 million extension.
A Stealth Startup Thinks It Just Hacked the Memory Shortage
Kepler Computing claims a new approach to chip design—and a proprietary material—can help end the supply bottlenecks that have sent memory prices surging.
Mbappé Puts Champions League Glory Ahead of Ballon d’Or
Kylian Mbappé used his post-match remarks after Real Madrid’s 2-1 Champions League win over Inter to name the trophy as his foremost ambition at the club, according to Marca. The France internation...
RUNC: Advaith Cheruvu
The senior strives to make next-generation computing technologies more powerful and practical.
Mental health survey finds Yampa Valley residents struggle with loneliness, substance use disorders
The Steamboat Springs City Council heard a sobering assessment of behavioral health in the Yampa Valley on Tuesday: Despite strong awareness of local resources and a reputation for community support, many residents still face loneliness,...
America Is In Pain. Flagler Health Is Transforming Clinics On The Front Lines
Hinge Health put MSK care on the digital-health map. Flagler's $50M Series B reflects a different bet: use AI to transform the specialty clinics where care still happens
Lease dispute between Wegmans, Cary landlord heats up
A federal judge ordered Wegmans to pay $625,000 into court while the grocer battles its Cary landlord over an unbuilt store at Fenton.
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget
A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.
Courtois to put Belgium career on hold
Goalkeeper Thibaut Courtois said in quotes published on Wednesday he has decided to put his Belgium career on standby until September 2027."If the goalkeeper playing in the Nations League performs well, Van Bommel might continue with him.
GOP's first midterm convention kicks off Wednesday, putting Dallas at center of national politics
The Republican Party's first-ever midterm convention begins in Dallas as Trump and GOP leaders rally voters, while Democrats prepare their own counterprogramming ahead of November.
Mayoral candidates must improve public engagement; Prop 134’s flawed science (Letters)
Currently, there is little effort by the City of Boulder to bring opposing groups together to seek common ground. Public input is only solicited after a department has made a decision, so that “engagement” feels like a sales pitch. Boa…
Epic v. Health Gorilla: “Working as Designed”
We’ve been on a bit of a legal bender since just before Labor Day, so let’s keep a good thing going! As predicted, Epic does not want its case against Health Gorilla consolidated with the data breach cases, so it filed a motion to vacate the conditional transfer. And because they had to explain to the Panel why this case is different, they put a good chunk of previously unseen Epic v. Health Gorilla discovery record on the public docket! Roll the tape! The Case Against Consolidation Before we get to the fun stuff, let’s do the housekeeping. Epic's motion boils down to three arguments (sorted in ascending order of how well they land): A judge has already decided this. Judge Olguin declined to relate the fraud action to another ELU case (Patterson v. UVA Health), holding that the two do not call for determination of substantially similar questions of law or fact. Epic asks the Panel to treat that (a Rule 42 ruling) as law of the case. The overlap is thin. The three common questions Health Gorilla and the Panel identified are neither numerous nor complex (the qualities the Panel looks for before centralizing). Moreover, they are outnumbered by the questions unique to each side: The breach cases turn on security architecture, notification timing, and patient-level access. The fraud action turns on false treatment attestations and breaches of the framework agreements. Consolidation costs more than it saves. 17 of 21 parties in the fraud action do not appear in a breach case. The cases are also at very different stages: Olguin has a scheduling order running through a January 2028 trial while the breach actions are much more nascent. I like the last two more than the first because they attack the basic economics of an MDL: there just may not be enough shared discovery here to justify dragging all the defendants and a relatively mature fraud case all the way to Florida. On the other hand (while I know exceedingly little about MDL and Rule 42), I have a hard time seeing why a district judge's decision about his own docket would control what the Panel does with the separate § 1407 question. I might be reading between the lines too much, but I sorta think Epic's own brief half-concedes this, framing the two provisions as "two sides of the same coin" but then adding "respectfully submit" (which is often lawyer speak for “we know this is a reach”). The Ladder Gets More Rungs Anyway, the arguments are not why you're here (aside from the lawyers, maybe). Back in June, we discussed how Epic was using the smaller defendants to build an evidentiary ladder toward Health Gorilla and Unit 387. Turns out discovery has been adding a few rungs of its own.
Cowboys Issued Strong Josh Sweat Take Amid 49ers Speculation
The San Francisco 49ers need more of a running mate to go along with Nick Bosa. Moreover, the Niners shouldn’t put all their hopes of sacking the quarterback on Bosa, given his injury history; he’s dealt with tendinitis during training camp and the preseason. As a result, the Niners could use the first two months […] The post Cowboys Issued Strong Josh Sweat Take Amid 49ers Speculation appeared first on HEAVY.
How the surging yen could hit your portfolio
The yen carry trade lets investors borrow cheaply in Japan and put the money into higher-yielding currencies and riskier assets around the world.
Entertainment District Around Akins Ford Arena Starts to Take Shape
Selling or leasing county-owned property around Akins Ford Arena has always been part of the plan for funding its construction, and the Athens-Clarke County Commission took another step toward that goal last week. The county is putting a parcel known as the Kelley Diversified tract on Willow Street up for sale. The old City of Athens bought the land and built a warehouse in 1970, and for a time it was used for vocational training. The unified government declared it surplus in 2007, but bids came in well below expectations, so it was never sold. However, since then the area between downtown and the North Oconee River has been built up, so the property could be more desirable to developers […]
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize
Joint research team modeled a 12,635-atom protein, the largest-known to be simulated using quantum computers. Breakthrough was achieved through quantum and classical methods working together, expanding quantum-centric supercomputing’s potential in life sciences research.
Final Pickin' in the Park of 2026 season
Put on your dancing shoes for the last Pickin’ in the Park of the summer from 6-9 p.m. Friday, Sept. 11, at the Canton Recreation Park.
Brendan Schaub Trashes UFC 332 Main Event
Former UFC heavyweight fighter Brendan Schaub trashed the upcoming UFC 332 main event between Natalia Silva and Wang Cong.With Valentina Shevchenko out for one year due to injury, she was forced to vacate the UFC women’s flyweight title, so Silva and Wang will now fight for the undisputed strap in the UFC 332 headliner.It’s a […] The post Brendan Schaub Trashes UFC 332 Main Event appeared first on HEAVY.
Qunabox Group Opens '99 Quna Festival,' Debuting Consumer-Facing Physical AI Entertainment
Hong Kong-listed Qunabox Group Limited (0917.HK) opened its "99 Quna Festival" here on Sept. 9, putting its consumer-facing physical AI entertainment business in the spotlight for the first time.
Mack Cleveland: Using computational materials science to engineer higher burnup fuels
Propelled by a love of mathematics and materials science, the MIT doctoral student models granular chemical reactions in uranium dioxide, work that might lead to less fissile nuclear waste and improved plant performance.
Canfield Fair incident puts focus on political rhetoric in Ohio governor’s race
For months, Ohio’s governor’s race has been fought with increasingly personal campaign messages.Now, after an armed man pushed through a crowd toward Democrati
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize
Cleveland Clinic, RIKEN and IBM has been named as a finalist for the 2026 ACM Gordon Bell Prize for simulating the largest biologically meaningful molecules ever modeled with quantum computers, reaching a scale of 12,635 atoms.
Oklahoma business feels impacts of Canadian tariffs
Failed trade negotiations in August led to the U.S. putting a 50% tariff on $20 million of Canadian products.
Youth sports become big business, putting stress on families and leaving some behind
Roughly 5 million kids are competing for travel or club sports teams that have cropped up across the country. Many benefit from that participation, including some who get college scholarships, but youth travel sports also come with increasing costs and challenges. As Stephanie Sy reports, those trade-offs and concerns are a part of the story that's getting more and more attention.
Carlos Augusto: "Never easy playing here, we show character"
Inter leave the Bernabéu defeated in their opening match of the 2026/27 Champions League: despite putting in a great performance and creating a huge number of chances, the Nerazzurri were defeated 2-...
Smithfield Foods expects to swing to third-quarter operating loss in fresh pork business
Smithfield Foods said on Tuesday its fresh pork segment is expected to swing to an adjusted operating loss in the third quarter, due to persistent pressure from lower hog prices and a shrinking industry market spread amid cautious spending.
Putin and Trump discuss Ukraine in 'extremely frank' call
Washington has been pushing for fresh face-to-face talks between Moscow and Kyiv to reach a peace deal
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information
One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
Politics News Site NOTUS Rebrands as The Washington Sun
A trademark dispute scuttled its plans to relaunch as The Washington Star, so the site chose a different name.
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Google Cloud Boss Makes Bold Claim About AI Chip Business
In a boost for Google stock, cloud computing chief Thomas Kurian says AI chip business is more than twice the size of its closest rival.
Arsenal 2-1 Chelsea win changes the transfer-window conversation
Arsenal’s win over Chelsea put the transfer debate into perspective, with the champions showing why their existing squad may already be strong enough.Photo by Ryan Pierse/Getty ImagesI don’t know ...
Ham: Kings Rejected LaVine-Young Swap
As the Sacramento Kings continue to rebuild, the front office has clearly put a focus on getting younger. Zach LaVine and Domantas Sabonis are two players to monitor as the season progresses to see if the team is looking to deal one of their former NBA All-Stars.
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
🚨XIs ready: City visit Porto in their European opener
Estádio do Dragão is getting ready to host an electrifying UEFA Champions League opener. Francesco Farioli’s FC Porto come into it on fire after putting together seven straight wins and opening th...
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
New Cancer Care Technology at Intermountain Health St. Mary’s Improves Precision and Comfort for Western Colorado Patients
Intermountain Health St. Mary’s Regional Hospital has invested more than $2 million for new equipment and technology to improve quality of care and comfort of their patients receiving cancer care in the Grand Junction area.St. Mary’s Cancer Centers of Colorado purchased a new a new computed tomography (CT) scanner that offers several enhance...
Hidden camera found in bathroom of Volusia County pet daycare business, owner arrested, deputies say
The owner of a pet daycare and boarding facility in Volusia County has been arrested after a hidden camera was found in the facility's bathroom, according to the Volusia County Sheriff's Office.
Hidden camera found inside bathroom leads to arrest of Volusia County man, deputies say
He faces 10 counts of digital voyeurism and 11 counts of video voyeurism of a child.
Mets Minor League Players of the Week: Week Twenty-Four
What minor league players put up the best numbers this past week, September 1st to September 6th?
Pete Davidson reveals emotional 9/11 connection to Michael Strahan: ‘You put me on your shoulders’
In a new documentary, Davidson and Strahan recall and relive the happy meeting that took place amid tragedy and pain.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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Computer Science Honor Society meeting Sept. 9
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