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This public health week, the US is squandering health and wealth
The human costs of underfunding public health are not abstractions.
Pediatric ICU nurse brings clinical insight to global health policy analysis | Harvard T.H. Chan School of Public Health
Heesu Shin, SM ’26, helped take care of kids at his hospital in South Korea. Now, he’s working to help them on a larger scale through his research.
Immunic COO highlights the importance of science-led innovation to mark World Health Day
Immunic Inc (NASDAQ:IMUX, FRA:10VA) chief operating officer Jason Tardio talked with Proactive's Stephen Gunnion about the importance of science-led innovation in tackling neurological diseases, particularly multiple sclerosis, on World Health Day 2026. Tardio highlighted that the biotech industry is fundamentally grounded in scientific research and data, noting that “everything we do is rooted in science.” He explained that Immunic is focused on developing innovative therapies designed to improve patient outcomes and address significant unmet medical needs. The discussion centred on multiple sclerosis (MS), a complex neurological disease that continues to present challenges despite decades of progress. Tardio pointed out that while advancements have been made, “the disease is not solved for,” with many patients still experiencing disability progression and requiring safer, more tolerable treatments. He emphasised the urgent need for innovation, particularly in progressive forms of MS where treatment options remain extremely limited. Immunic’s lead asset, vidofludimus calcium, is being developed as a novel approach aimed at addressing the full spectrum of the disease. Tardio also reinforced the broader mission of the healthcare and biotech sectors, stating that the ultimate goal is to help individuals “live a better quality of life” and “a healthier life longer.” Watch the full interview to learn more about Immunic’s approach to advancing MS treatment through science. For more videos like this, visit Proactive's YouTube channel, like this video, subscribe to the channel, and enable notifications so you never miss an update. #Immunic #MultipleSclerosis #BiotechInnovation #Healthcare #MSResearch #DrugDevelopment #ClinicalTrials #Neurology #WorldHealthDay #ScienceDriven #VidofludimusCalcium #PharmaNews #BiotechNews
State’s first Health Learning Lab opens at Waianae High School
The lab provides students with hands-on clinical skills training in a modern setting and supports certificate programs designed to lead directly to entry-level healthcare jobs.
AI finds drug safety signals in clinical notes
Large language models were tested on cancer patient notes from two academic medical centers and seven drug trials.
Auraria Health Center offers same-day appointments and free services for faculty and staff
Same-day medical appointments and no-cost health services are available to faculty and staff members through the Health Center at Auraria, offering a convenient alternative to long wait times for primary care. The center offers a broad range of clinical services, including primary care, psychiatric support and telehealth appointments. Faculty and staff can also be seen for sick visits, including infections, […]
‘Building a better future’: UCLA receives $33 million to address LA’s youth mental health crisis
The Ballmer Group investment will support academic and clinical training that will bring more Bruin practitioners into local communities.
Embedded mental health clinical interns quickly connect people to support
Counseling Service of Addison County’s embedded master’s-level clinical internship program connects people to services, offering support from a familiar face within a trusted agency. Interns gain close supervision and guidance from expert staff in an established Community Mental Health Agency.
Senior Spotlight 2026: For this aspiring physician, computer science is ‘empowering’ asset
Rice senior Pankti Mehta is channeling her drive to improve how people access and experience health care by combining computer science with hands-on clinical insight.
East Lansing Insider Podcast: A Conversation with Acorn Health
On this week's podcast, ELi Deputy Editor Anna Liz Nichols talks about autism awareness and acceptance with Paul Doher, national director of clinical quality for Acorn Health.
A global consensus establishes a basis for measuring and improving gut health
While “gut health” is becoming a popular term, mainly in media and marketing claims but also in the clinical context, researchers have not yet nailed down a definition. Now, a global group of 13 scientists and clinicians updates a consensus definition of gut health and implications from bench to bedside.
Return to Sport Rates Following Total Knee Arthroplasty
A recent study shows that understanding timelines and key factors could help clinicians give tailored advice and set realistic expectations for their patients undergoing TKA.
Mercy Health outsources 24/7 critical systems monitoring
The Catholic-run healthcare provider has moved to managed monitoring of its clinical integration systems to improve incident response and reduce downtime across its services.
Fayette County Annual Report Highlights Local Public Health Efforts
Article presented by McDonald’s, I’m Lovin’ It! … Fayette County Public Health (FCPH) has released its 2025 Annual Report, showcasing the department’s work to protect health, prevent disease, and promote wellness across the community. The report highlights the impact of public health services delivered throughout the year, including clinical care, environmental health, school-based services, emergency preparedness, and community outreach initiatives. In
RAM pop-up clinics provide free medical, dental, and vision care to uninsured or underinsured Americans
Preparing the Next Generation of Alcohol and Drug Counselors
UNO’s Clinical Mental Health Counseling program is expanding its reach and impact by offering students a pathway to dual licensure in both mental health and substance use counseling. In just two additional courses beyond their required coursework, students can become eligible for Nebraska’s Provisional Licensed Alcohol and Drug Counselor (PLADC) credential.
Some Essentia Health clinics impacted due to inclement weather
Due to inclement weather, the following Essentia Health clinics are closed or have a delayed opening today, Saturday, April 4.
Okaloosa County School District opens employee health clinic
The Okaloosa County School District has opened an employee health clinic. The ribbon cutting was April 2, 2026.
Medicines watchdog to investigate UK peptide clinics over health claims
Exclusive: Guardian investigation finds several clinics making potentially unlawful claims about benefits of unregulated therapies
Oregon gave millions in erroneous benefits for state health plan, audit says
By Shaanth Nanguneri, Oregon Capital Chronicle SALEM, Ore. -- A free Oregon health care program for adults who make too much money to qualify for Medicaid could have improperly given out $15 million in payments related to benefits for recipients, according to a recent audit of state-managed federal programs. The “questioned” funds surfaced in an 124-page
DHS shutdown, HB 8002, State of the Bears: CT politics news
Plus: Updates on family planning clinic funding, an ambitious reading pitch, and a proposed penalty for replacing workers with AI.
The health benefits of spicy foods
Spice up your plate: learn how capsaicin in chile peppers may support heart health, reduce inflammation, boost mood, and fit into a balanced diet.
Wearable Health Devices in Clinical Care
Wearable health devices like smartwatches may be increasingly used in clinical care, as FDA policy shifts may accelerate adoption.
Café Piro earns James Beard finalist spot; city opens health clinic in Central
This week: Café Piro reaches James Beard finals as El Paso opens a new health clinic, plus updates on trails, public art and EPCC César Chávez holiday changes.
Maui Mental Health Providers Face Stress And Uncertainty About State Jobs
Staff at a state-run clinic serving wildfire survivors in Hawai‘i have waited months for permanent jobs. Instead, they got another temporary contract.
Maui Mental Health Providers Face Stress and Uncertainty About State Jobs
Staff at a state-run clinic serving wildfire survivors in Hawaii have waited months for permanent jobs. Instead, they got another temporary contract.
New Webinar Series Explores Relationship Between Microbiome and Health
The free virtual series is open to students, researchers, clinicians and anyone from the public with an interest in microbiome science.
Sexual Healthcare for Cancer Survivors
Pelin Batur, MD, advocates for clinicians to help patients with cancer by prioritizing the sexual-health treatments supported by strong data.
New mobile health clinic launches in Burlington County
Migration can influence cardiovascular risk profiles, study shows
A new study shows that migration from Mexico to the United States can influence cardiovascular risk profiles. The study's findings are important for clinicians who serve immigrant populations and who ...
Officials launch new mobile health clinic to serve Burlington County, New Jersey
Iterative Health, US Heart & Vascular Partner to Advance Community-Based Cardiovascular Research
April 2, 2026 — Iterative Health and US Heart & Vascular (USHV) have announced a strategic partnership to advance research through community-based innovation in cardiovascular care. "Clinical research is one of the most powerful ways we expand access, improve patient outcomes, and shape the future of cardiovascular care," said Robbie Allen, chief executive officer of US Heart & Vascular. "By partnering with Iterative Health, we are strengthening our ability to bring innovative therapies directly into the communities we serve. This collaboration ensures our physicians and patients have access to leading-edge trials while allowing US Heart & Vascular to remain focused on delivering exceptional, physician-led care." Under the agreement, USHV research sites will join Iterative Health’s global site network, which now spans over 100 sites across three continents. The companies share a commitment to advancing clinical research as a driver of care innovation, and this collaboration represents a major milestone for both organizations, strengthening USHV's leadership in community-based cardiovascular research and expanding Iterative Health's multispecialty focus beyond GI, hepatology, and obesity into cardiology. USHV clinical research sites will gain access to Iterative Health's centralized operational backbone, providing end-to-end support across clinical research operations, services, business development, technology innovation, and corporate functions. The strategic partnership reduces operational complexity and unlocks growth potential for USHV research sites while enabling all USHV physicians to expand access to cutting-edge therapies to the thousands of patients they serve annually. "Innovation in cardiovascular medicine shouldn't be limited to a few academic centers," said Thomas Waggoner, DO, MD, RPVI, FACC, FSCAI, FSVM, RPVI, Structural Cardiologist and Medical Director for Clinical Research at Pima Heart & Vascular, and USHV Physician Champion for Clinical Research. "By expanding community-based research across USHV, we're ensuring more patients have access to clinical trials and breakthrough therapies close to home, where trusted relationships with their physicians already exist." This alliance reinforces Iterative Health's standing as the definitive research partner across specialized therapeutic areas, now spanning GI, hepatology, obesity, and cardiovascular care. Trusted by many of the nation's leading provider organizations and biopharma sponsors, Iterative Health's global site network delivers industry-leading trial performance, accelerating life-changing therapies to market at scale. "Entering cardiology through our strategic partnership with US Heart & Vascular is a defining moment for Iterative Health and reflects the strength of our site-serving model," said Jonathan Ng, founder and CEO of Iterative Health. "Together, we are ensuring that thousands of patients have access to the newest available therapies, and that sponsors have a credible, high-performing partner to accelerate cardiovascular trial success." For more information, visit www.iterative.health and https://usheartandvascular.com/.
Mount Sinai to integrate OpenEvidence AI enterprise-wide
By embedding OpenEvidence directly into its Epic electronic health records, the New York health system aims to change how its clinicians access health data at the point of care to improve patient outcomes.
ArchWell Health opens 4 new senior care clinics in Northeast Ohio
The Medicare Advantage-focused health provider will host grand openings throughout April in Cleveland Heights, Euclid and two Cleveland neighborhoods, bringing its regional total to nine centers.
New weight-loss pill hits the market, promising 'greater flexibility'
FDA approves Foundayo, a once-daily weight loss pill by Lilly. Clinical trials showed adults lost an average of 27.3 pounds on the highest dose, although there are side effects.
Sharing her passion for science
By Danielle Rush Communications Specialist, Indiana University Kokomo Hisako Masuda, Indiana University Kokomo professor of biochemistry, was honored by the Indiana Academy of Science (IAS) as its 2026 Distinguished Scholar. The award is given to an individual who is recognized by the IAS as having an exceptional record of scholarship. Recipients are selected from nominations submitted to its awards committee. “I was surprised,” said Masuda, who joined IU Kokomo’s faculty in 2013. “I feel there are many good scientists in the Academy, so I wasn’t expecting it at all.” Patrick Motl, dean of the School of Sciences, said the Academy recognizes up to one member per year, and that Masuda is the second or third IU Kokomo faculty member to receive the commendation. “Clearly this speaks to the strength of Dr. Masuda’s accomplishments in research and scholarship and that her work stands out amongst her peers in Indiana,” said Motl, who received the award in 2019. “Many of the institutions that participate in the IAS are undergraduate institutions or primarily undergraduate institutions, but even having that caveat, Dr. Masuda has built and maintains a very active research program in her lab, working exclusively with undergraduates. She is passionate about science and can share that passion with her students. To carry on a quality research program with so many students involved in so many projects is truly remarkable and I am glad that the IAS acknowledged that for Dr. Masuda.” The IAS specifically commended her for involving more than 50 undergraduates in her research in bacterial metabolism, genomics, and their phenotypic plasticity at IU Kokomo, and publishing 23 articles with many student co-authors. Masuda’s current work primarily focuses on biodegradation and chemical repurposing of nylon. Using soil bacteria, her lab studies bacterial biodegradation of nylon and other environmental pollutants. She applies principles of green chemistry while developing a method to convert nylon waste into other nontoxic polymers. In collaborative work with health scientists, her lab investigates gut microbiomes of Indiana native birds as well as human subjects in a clinical study. She became interested in converting plastic waste while earning her Ph.D. at Rutgers University, working on methods to remove environmental waste not using chemicals or other intrusive methods. She learned about Nylon 11, which is used in pipes for transferring oil, interior components for cars, catheters, and in other industrial hard plastics. Nylon 11 is nontoxic, she added, so it is safe to include students in the research. “Those are considered to be nonbiodegradable, and have to go to a landfill,” she said. “I thought if we could come up with a way to biodegrade it, that would make some kind of impact.” Eventually, she wants to develop a product that would convert nylon waste to something useful, and to reduce waste and microplastics in the environment. “That would be my goal at some point, that we can make that change, and also make people more aware of their use of plastics,” she said. “I hope students stop to think about what we can do as scientists to address issues currently impacting us.” She appreciates the IAS for its support of scientific research at Indiana institutions, and IU Kokomo and the School of Sciences for providing funding for students to attend the Academy’s annual meeting. She added that IU Kokomo has also supported her research with funding from the School of Sciences and Academic Affairs. “Without that, I couldn’t do my research,” she said. Masuda has also earned a Senior Research Grant from the IAS, IU Kokomo’s Distinguished Research Award, and the IU Kokomo Junior Faculty Annual Research Award. She is a Fellow of the Indiana Academy of Science. Education is KEY at Indiana University Kokomo.
Panoramic Health and West Coast Kidney Institute Launch Concord Cardio-Renal Research Institute to Advance Clinical Trials in Cardio-Renal-Metabolic Disease
/PRNewswire/ -- Panoramic Science, the clinical research division of Panoramic Health, and West Coast Kidney Institute today announced the launch of the...
UAB launches Moms and Kids Mobile Health Clinic, expanding maternal and child health care access across 17 rural counties
UAB launches Moms and Kids Mobile Health Clinic, expanding maternal and child health care access across 17 rural counties
Health clinic for low-income families open in Panorama City
The clinic will provide primary and pediatric care, dental services and treatment for chronic conditions such as diabetes and hypertension, officials said.
MultiCare Rockwood Clinic recognized by Washington Health Alliance
Washington Health Alliance recognizes MultiCare Rockwood Clinic for delivering high‑quality, low‑cost care across the Inland Northwest.
Reproductive health care restrictions likely to repel provider workforce, research shows
Applications to medical residency programs in states with abortion restrictions have declined compared to states where abortion remained mostly legal.
Washington doctors are sounding alarm on cannabis health effects, survey shows
More than a decade after recreational cannabis was legalized in Washington, a new survey of health care providers suggests many clinicians are concerned about its effects on patients’ mental health.
We’re Spending Billions on Collagen. Here’s What the Science Actually Says
We’re spending billions on powders and gummies, but is it a waste of money? Discover what recent clinical studies from Harvard and FSU reveal about collagen's actual impact on skin, joints, and aging.
HHS Is Exiling Top Officials to the Indian Health Service
The Indian Health Service needs more clinical workers. The federal health officials being transferred to the agency don’t fit that bill.
Title X funding for reproductive health care could lapse due to Trump admin delays
Some clinics that rely on Title X grants to provide birth control, cancer screenings and STI testing are making contingency plans as the government appears likely to miss its deadline.
NFL owners approve mandate that teams employ full-time mental health clinicians
Previously, teams were required to have one clinician work eight to 12 hours per week over a two-day span.
Nebraska DHHS seeking rural health experts to join federal program advisory group
The Nebraska Department of Health and Human Services is creating an advisory board for the Rural Health Transformation Program. Though the program’s budget has been set, board members across six regions will assess how prepared hospitals and clinics in their region are to implement program initiatives.
WHOOP Raises $575 Million at $10.1 Billion Valuation to Advance Global Health Platform
BOSTON, March 31, 2026--WHOOP, the human performance company, today announced it has raised $575 million in Series G funding at a $10.1 billion valuation, advancing its global expansion and long-term vision for personalized health. The round was led by Collaborative Fund and includes global participation from 2PointZero Group, Qatar Investment Authority (QIA), Mubadala Investment Company, Abbott, Mayo Clinic, Macquarie Capital (entities administered by Macquarie Capital), Glade Brook, B-Flexion,
Mount Sinai Health System Collaborates with OpenEvidence to Provide Evidence-Based Knowledge Within Electronic Medical Record
Collaboration extends access to all clinical users, including nurses and pharmacists
Boone Health sues cardiology group; coverage change to affect over 20K patients
Boone Health filed a lawsuit against Missouri Heart Center, alleging the cardiology group is trying to open a new clinic in Columbia.
Kettering Health Greene Memorial Celebrates 75 Years
Kettering Health Greene Memorial is celebrating its 75th year in Xenia, a legacy marked by advancements in clinical excellence and strong community ties.
Survey: More than half of Washington clinicians cite mental-health risks from cannabis use
More than a decade after Washington legalized recreational cannabis, a new survey suggests many clinicians are increasingly worried about the mental-health risk
Cannabis-related health problems: WA clinical snapshot - UW Medicine
News and information for journalists
A Nurse Educator on Resilience, Patient Care and the Future of Health - Newsroom | University of St. Thomas
Faculty member Dr. Vane Gichana brings a blend of clinical judgment and critical thinking when she instructs nursing students at St. Thomas.
New £1.5m research facility plan for New Cross Hospital
A new clinical centre will bring big benefits for patients, staff and the health system, say bosses.
Michigan Medicine study shows emoji usage increasing in electronic health records
The study published Jan. 14 analyzed clinical notes from electronic health records and found clinicians are using emojis more often.
UCLA's first dean for Health AI Strategy and Innovation takes office
“The creation of an associate dean in AI speaks to the fact that AI has become central to research, education and clinical operations in the health care system."
UCLA's first dean for Health AI Strategy and Innovation takes office
“The creation of an associate dean in AI speaks to the fact that AI has become central to research, education and clinical operations in the health care system."
Support beyond the classroom: Little Rock’s community schools offer health care, therapy, a student bank and more
At first glance, Chicot Elementary is just like any other school. But walk past the bright hallways plastered with crayon drawings and "I can count to 100" worksheets and through a gym lined with balance bikes, and you'll find clinics that provide vaccines, lab work, eye tests, counseling and language interpretation for Little Rock School District students and their siblings.
Ingredion and Holobiome map gut microbiome to unlock targeted health benefits
Ingredion has partnered with Holobiome to use AI and its database of two million bacterial genomes to predict how specific ingredients will interact with human health before clinical trials. The research expands beyond digestion to explore how sweeteners, plant proteins, and texture solutions influence the gut-brain axis, including sleep and mental health.
Trump’s One Big Beautiful Bill Act darkens outlook for government-backed clinics
About 17,000 fed-funded health clinics stand to collectively lose $32 billion in next five years as more uninsured patients rely on them for care
How Are Health Systems Assessing ROI for AI Tools?
Michael Meucci, CEO of health data platform Arcadia, thinks health systems are changing their thinking about ROI when it comes to AI projects. As providers face tighter budgets, he said they’re broadening how they measure AI’s ROI, including benefits like reducing clinician burnout.
The Guardian view on peptides: Robert F Kennedy Jr would leave public health policy to the hucksters
Editorial: The US health secretary says he is a big fan of peptides. Many are promising drugs, but the only way to know their utility is proper clinical trials
Downtown North Augusta clinic expands holistic health services with acupuncture
Licensed acupuncturist Hartford B. Campbell has joined Aiken-Augusta Holistic Health, located in downtown North Augusta and serving the CSRA with integrated medicine for nearly 20 years.
Inside the high-stakes business battle over feeding preterm babies
A clinical trial among preterm babies gives a view into corporate warfare in the high-stakes business of infant nutrition.
Cam Schlittler, Yankees dominate Giants for second straight shutout
Aaron Judge and Giancarlo Stanton provided the punch to back a pitching clinic by the Cove.
Boston Children's enhances care with clinical intelligence platform
Two of the hospital's physicians explain how the decision support technology aggregates patient signals to indicate health trajectories – which tells clinicians when to evaluate a patient's evolving state and determine an appropriate response.
Firetruck crashes into Quincy native’s Nashville business
A firefighter is recovering after crashing a fire engine into a Nashville chiropractic clinic owned by Quincy native Kevin Bradshaw.
Exclusive: Sage Health raises $50 million in debt for value-based care expansion
Despite headwinds, some investors still see opportunity in brick-and-mortar clinics.
Jeremy Melander joins Essentia Health-32nd Avenue Clinic to practice orthopedic surgery
The Essentia Health-32nd Avenue Clinic is excited to welcome Jeremy Melander, an advanced practice registered nurse and certified nurse practitioner in orthopedic surgery.
Vaccines for healthy pre-teens and teens
Adolescents ages 9-18 are due for key vaccines. Uninsured youth can get free vaccines from the City of Berkeley Immunization Clinic. Parents of uninsured adolescents can come to the City of Berkeley immunization clinic to check their child’s vaccination status and, if needed, catch up on their missing shots.Staying up to date on vaccines is important for families at a variety of ages. Adolescence is an important time to check vaccine status as kids age 9 to 18 can get proven protections to help protect against of a variety of diseases.
Two Northside leaders named 2026 Health Care Champions
Lynn Jackson, president and CEO of Northside Hospital Forsyth, was named Health Care Executive of the Year, and Christine Bree Becker, lead nurse practitioner for the Maternal Heart Health Clinic at the Northside Hospital Heart Institute, was named Innovator of the Year in Women’s Health at an awards ceremony on March 19.
Exclusive: Blossom Health raises $20 million to bring an AI ‘copilot’ to psychiatry
The startup says its “AI-native” model can deliver faster access to care while keeping clinicians in control of treatment decisions.
Five Tactics to Modernize Healthcare Data and Analytics
Cleveland Clinic’s Chief Analytics Officer shares insights on the tactics that shaped the organization’s transition to data modernization.
PhysioNet as a global platform for biomedical research
Nature Health - Twenty-five years after its first public repository was established, the PhysioNet resource for biomedical and clinical data has enabled tens of thousands of research papers....
Greenville women’s health clinic closing after nearly 40 years
Physicians East announced that Greenville Women’s Care, located on Stantonsburg Road, will close on June 1, 2026.
UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio
Contact: Eileen Teves, 210-450-7239, tevese@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, March 25, 2026 – UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is launching a multi-phase clinical study to better understand how the drug rapamycin may promote healthy aging. Funded by the National […]
Essentia Health-Duluth Clinic welcomes Mariah O’Connell to practice family medicine
Mariah O’Connell, an advanced practice registered nurse and certified nurse practitioner specializing in family medicine, is thrilled to join the Essentia Health-Duluth Clinic.
Essentia Health-Duluth Clinic welcomes Marijah Harney-Tolo to practice dermatology
Marijah Harney-Tolo, an advanced practice registered nurse and certified nurse practitioner specializing in dermatology, is thrilled to join the Essentia Health-Duluth Clinic.
UCLA Health receives $2.4 million from Rose and Allen Nelson to establish a fellowship in translational and clinical neuroscience
The gift is being made in memory of their son Brandon, who received his bachelor’s in aerospace engineering from UCLA in 2014.
Pharma bribery corrupts health care, puts patients at risk, new review warns
Sham clinical studies, slush funds and shell companies: A new review shows how pharma firms allegedly bribed their way to drug approvals and sales.
FDA clears portable photon-counting CT scanner
The system is designed for point-of-care settings such as outpatient offices, sports medicine practices and urgent care clinics.
Confluence Health physician assistant recognized with statewide award
WENATCHEE — A Confluence Health clinician was named the Rural Physician Assistant of the Year earlier this month by the Washington Academy of Physician Assistants.
UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio
Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]
ENvue Medical Expands Presence within a Major Michigan Health System and Grows U.S. Hospital Footprint to 39
Premier 714-bed teaching hospital and Level I Trauma Center purchases ENvue™ Navigation Platform system and feeding tubesTYLER, Texas, March 24, 2026 (GLOBE NEWSWIRE) -- ENvue Medical, Inc. (NASDAQ: FEED) (“ENvue,” “ENvue Medical” or the “Company”), a medical technology company specializing in the advancement of intelligent, non-invasive solutions for enteral care across clinical and home care settings, today announced a purchase of the ENvue™ Navigation Platform and feeding tubes by a premier t
Peninsula Community Health plans to add 2 Bremerton dental clinics
Peninsula Community Health Services, with state funding coming from back-to-back budgets, will open to two new dental clinics along Kitsap Way.
The Family Van brings free health screenings to Boston neighborhoods
With barriers rising in health care access, mobile clinic fills critical gaps
Across Tanzania, Medical Refrigerators Preserve Life and Health for Kids with Diabetes
The technology Tanzania’s children with diabetes needed most urgently wasn’t a cutting-edge treatment. It was refrigeration. Local public health clinics across Tanzania provide monthly checkups for…
Berrien County Health Department will hold free hearing, vision screenings for kids
The Berrien County Health Department will offer free hearing and vision screenings for kids throughout spring break.Clinics will be held March 30 at the departm
Dean for Basic Science Colin Duckett tapped to serve as Boston University Provost
Duckett, executive vice dean for basic and preclinical science, will begin his tenure as chief academic officer at Boston University starting in July.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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