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June business news, Texas Tech series make Lubbock headlines
Business Reporter Alana Edgin reviews recent Lubbock area business news and hints at upcoming articles in the weekly Around the Hub column.
Euro-Zone Business Activity Revised Up to Stagnation for June
Business activity in the euro area was better than initially thought last month, with the bloc recording stagnation rather than shrinking.
Richard Hughes has the perfect midfield signing for Liverpool
Liverpool's midfield is one of their main areas that needs to be revamped. Alexis Mac Allister and Ryan Gravenberch both failed to meet expectations last term with their inability to run one of their ...
Valley Golf Center owners say it's been an 'honor' as business closes
KMPH Fox 26 is the Central Valley's news leader, covering Fresno, California and the surrounding area, including Clovis, Madera, Hanford, Visalia, Biola, Kerman, Tranquillity, San Joaquin, Reedley, Coalinga, Avenal, Lemoore, Tulare, Selma, Caruthers, Tollhouse, Three Rivers, Porterville, and Merced.
Decatur Square businesses thrive during 2026 FIFA Men's World Cup and WatchFest: "...beyond our wildest imagination"
Local restaurants and bars in Decatur Square are reporting record crowds and sales as soccer fans flock to the area for World Cup matches and WatchFest events.
Business excluded from DORA program in Goshen
Goshen's new Designated Outdoor Refreshment Area, or DORA, is officially underway.But not every downtown business gets to take part.Biebs and Ash on Main Street
Chattanooga-area business openings and closings in June 2026
Here's a look at the business trends for June in the Chattanooga area.
Negotiations between Cherriots, business leaders paused after months of meetings
Talks between the Salem Area Mass Transit District and representatives from a coalition of six business and real estate groups, and citizens were halted last week, Cherriots said in a press release. The two groups formed a task force to find a compromise after a proposed payroll tax sparked frustration last year. To comment on this story, use the form at the end of the report.
St. Louis-area businesses that have closed in 2026 so far
These St. Louis-area businesses have closed in the first six months of the year.
Former SPASH science teacher charged with possessing child pornography
USA TODAY NETWORK STEVENS POINT – A former Stevens Point Area Public School District teacher was charged June 24 with 10 felony counts of possession of
Giants' Matt Chapman goes on injured list with abdominal strain
Matt Chapman said his abdominal area had been bothering him over the last several weeks.
Public health advisory lifted for Fort Custer's Eagle Lake
A public health advisory has been lifted for Eagle Lake in Fort Custer Recreation Area, according to the Kalamazoo County Environmental Health.
What are the 'top workplaces' in the New Orleans area? Check out this year's awards.
The annual competition identifies exemplary companies via independent, anonymous surveys of their employees. This year, more than 41,000 workers were surveyed.
TPS decision causing uncertainty for Haitian business owners
While the legal battle over ending protections for Haitians continues, uncertainty is growing at area businesses in Springfield
TPS decision causing uncertainty for Haitian business owners
While the legal battle over ending protections for Haitians continues, uncertainty is growing at area businesses in Springfield
ArtBeat: Spotlight on the local arts events and entertainment
Here’s a closer look at what you can expect from the area’s events: July 3 First Friday Reception: The Downtown Art Market Gallery in Knoxville invites the community to its First Friday Reception from 5:30 to 9:00 p.m. July’s featured artist is Lynnda Tennpenny, who will showcase a collection of mixed-media artwork. Admission is free, […]
Bay Area Host Committee announces plans to become permanent sports leadership commission
The Bay Area Host Committee has announced plans to become a permanent leadership commission, continuing to bring sports events to the Bay Area.
CHAMP Initiative Combines Climate Science and Storytelling to Address Urban Heat
As summer temperatures climb, so does the risk of extreme heat—now recognized by the National Oceanic and Atmospheric Administration as the leading cause of weather-related deaths in the United States. In cities such as Camden, where buildings, pavement, and other infrastructure trap heat and create higher temperatures than surrounding areas, understanding the impacts of urban […]
Wright State President Sue Edwards Named to Dayton Business Journal’s Power 100
One hundred area leaders are being recognized for helping shape the Dayton region’s growth over the last 25 years. Continue reading →
Register to attend Rural Health Initiative series on substance use
Experts from the Johns Hopkins Bloomberg School of Public Health and WVU School of Public Health will discuss their experiences working with patients who use substances in rural areas and potential areas for future research projects from noon to 1 p.m. July 16 on Zoom.
Celebrate America's birthday with area parades, fireworks and festivities
From fireworks displays and patriotic parades to live music and food trucks, the Blackstone Valley is ready to celebrate Independence Day with a variety of festive traditions. This year’s Fourth
Another entertainment option is coming to an area already booming with them
Whitney and Thomas Hughes, who have an Escapology franchise in San Antonio, are bringing one to Wichita in the K-96 and Greenwich area.
USA vs Bosnia-Herzegovina – Predicted lineup and team news
San Francisco Bay Area Stadium hosts the World Cup last 32 on Thursday morning as USA take on Bosnia-Herzegovina, with a place in the round of 16 against Belgium or Senegal at stake.Mauricio Pochettin...
Washington County Quorum Court OKs business permits for HS Studios, Fox Hunter Landing
FAYETTEVILLE -- Washington County's justices of the peace on Tuesday approved a pair of permits for businesses seeking permission to operate in unincorporated areas of the county.
Multnomah County Just Fired a Key Health Leader. He Says He’s a Scapegoat in a Power Struggle.
Anirudh Padmala’s departure marks worsening tumult in the top leadership overseeing the network of 19 federally-funded Portland area clinics, which collectively serve tens of thousands patients annually.
Microsoft eyes thousands of new job cuts in coming days
Microsoft is planning job cuts that are expected to affect areas such as sales, consulting, and Xbox as it ramps up AI spending.
Small Businesses Could Lose Access To Billions In Contracts As New HubZONE Deadline Kicks In
Certain areas across the U.S. that were previously designated as HUBzones will see that status expire on July 1.
Santa Cruz County business filings: Week of June 30
Businesses operating in Santa Cruz County must register with the county clerk. Lookout Santa Cruz reviews the public filings from local businesses to report on new businesses starting in the area.
5 things to do this week in Greenville
See our curated list of upcoming and ongoing arts, culture and entertainment events in the Greenville area. Send us your events at greenville@postandcourier.com.
Bumpy road for Omaha business park boosted by $90M from state leads to first tenant, 150 jobs
The oft-bumpy road to an Omaha airport area business park boosted by $90M in state funds has led to its first tenant and 150 "quality" jobs.
Reaching communities close to hostilities in Ukraine
Primary health care teams in Ukraine are reaching 121 locations within 60 km from active hostilities. This is part of the largest primary health care intervention in frontline areas in the country. European Union (EU)-supported teams are delivering essential services to people trapped by constant shelling and severe security constraints in 7 regions where no pharmacies operate, no health facilities function and evacuation remains impossible for residents.
Nation’s largest industrial landlord bets $100M on Chicago warehouse demand
The project is a show of confidence by one of the biggest industrial property companies that the Chicago-area warehouse market has pent-up demand.
Munson Arts Festival Kicks Off July 11
Munson’s Arts Festival is set to bring a week of art, music and community events to the area.
South Coast Business & Technology Awards Gross Another Record Total for Area Scholarships
Credit: Courtesy Santa Barbara, CA — For the fourth consecutive year, the South Coast Business and Technology (SCBT) Awards ceremony has grossed
Silver Spring business releases 600,000 infected mosquitoes in DC area
In an innovative way to decrease the mosquito population, when one of the male ZAP mosquitoes being released mates with a female, she will no longer be able to produce offspring.
Silver Spring business releases 600,000 infected mosquitoes in DC area
In an innovative way to decrease the mosquito population, when one of the male ZAP mosquitoes being released mates with a female, she will no longer be able to produce offspring.
Austin Home Theater Helps Central Texas Homeowners Reimagine Entertainment With Custom Home Theater Design
Locally owned integrator combines decades of experience with personalized design to deliver cinema-quality systems across the Austin area
A tale of two World Cup experiences: As Boston reaps economic benefits, Foxboro suffers
With the World Cup taking place in their backyard, Foxboro-area restaurateurs say they have been left in the dark and are not reaping the benefits from the economic boom seen in Boston.
Is Miami Beach getting a new marine science hub? North Beach residents hope so
Neighbors want the center to educate young people about the area’s marine ecosystems while also serving as an attraction for visitors.
At Universal Horror Unleashed in Las Vegas, fear is always in season
Your nightmare awaits at the AREA15 year-round attraction.
San Jose business collects relief supplies for Venezuela earthquakes victims
Several businesses in the Bay Area are coming together to collect relief supplies for Venezuela following the deadly twin earthquakes that struck the nation.
Khalid Robinson takes next step as Warriors' head coach for NBA Summer League
As he enters his 11th season with the Warriors, Khalid Robinson is about to step into a new role as Golden State's NBA Summer League head coach
Warriors reportedly interested in three NBA free agents as LeBron decision looms
The Golden State Warriors reportedly have their eye on several players ahead of NBA free agency.
Bob on Business: Fort Worth Stockyards auction barn seeing new life as studio, live venue
Also, more Stockyards-area property on the market; area CEO honored; pawnshop deal; and another acquisition.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Multiple Portland-area mental health crisis lines down due to technical outage
Mental health crisis lines in Multnomah, Washington, and Clackamas counties are down due to technical issues, and officials are urging people to call or text 988 if they or someone they know is exp…
Pennsylvania measles outbreak tops 70 cases as health leaders pledge to get spread ‘under control’
The most recent measles outbreak started in the area of Lebanon and Lancaster counties in late April. Cases now span six counties.
Business briefs: Free summer health series in Schererville
News and events around the area
Business briefs: Free summer health series in Schererville
News and events around the area
Delaware's Most Influential and Inspiring in small business for 2026
Meet eight Delawareans making the list for Delaware Online/The News Journal's Most Influential & Inspiring in small business for 2026.
Rafael Devers stays silent after loud night at plate in Giants' win vs. Braves
Rafael Devers is back to not talking, even after two majestic homers in the San Francisco Giants' win on Saturday at Oracle Park.
Northern AZ business stays open for community during power shutoff
Arizona Public Service cut electricity to about 8,000 homes and businesses in the Flagstaff and Grand Canyon area Saturday morning.
Health care program in Boston working to ensure homeless women get care they need - Boston News, Weather, Sports
BOSTON (WHDH) - A health care program in Boston is aiming to ensure that homeless women in the area are getting the care they needRead More
Nintendo issues June 2026 backwards compatibility fixes for Switch games on Switch 2, full list
Another set of backwards compatibility fixes for Nintendo Switch games on Switch 2 are now available. There aren’t as many heavy hitters this time around, but it’s still a solid batch. Shovel Knight: Treasure Trove is the biggest name out of the bunch – previously, Nintendo said that players may encounter audio issues in some areas. The full list of...
Stephenson Business Center highlights local vendors, gives back to community
The Stephenson Business Center holds a community event Saturday with dozens of vendors and some giveaways for area residents.
Arts & Entertainment Calendar
Events coming up in the Greenville area offer music, arts, theater and family fun. Here is a sampling.
Hopewell's James Armstrong is the first sophomore to win Post-Gazette Athlete of the Year
James Armstrong is a teenager who doesn’t do well with downtime. Armstrong has a summer job as a maintenance worker at schools in the Ambridge Area...
CDFW News | Monterey Bay Northern Anchovy and Pacific Sardine Commercial Take Restrictions and Recreational Advisory in Place Due to Public Health Hazard
State health agencies determined that northern anchovy and Pacific sardine recently sampled from Monterey Bay contained elevated levels of domoic acid and recommended a commercial fishery restriction and recreational health advisory in the bay for the take of anchovy and sardine for human consumption in the area.
Public health alert issued for chicken sold at popular grocery store in the Tri-State area
A public health alert was issued for chicken sold at a popular grocery store chain in the Tri-State area.
Manufacturing business cuts ribbon in Putnam County, set to bring 120 jobs to area
The operation is a joint venture between global engineering group Sandvik and mining company Alpha Metallurgical Resources.
Trustees hear Glencoe neighbors who blast possibility of street parking near business district
Facing opposition from residents living adjacent to the Village’s business district, the Glencoe Village Board has adopted the findings of a long-in-development parking study without three areas that multiple residents spoke against during a recent Village Board meeting. In a 5-0 vote, with Trustee Dudley Onderdonk abstaining, the Glencoe Village Board on Thursday, June 18, […]
Early Homo sapiens may have lived in rainforests, new clues suggest — and it could overturn our understanding of human evolution
The long-held idea that rainforests held a minor role in our species' evolution is changing — and our ability to adapt to these tropical areas may give insight about 'what it means to be uniquely human.'
Climbing gym planned in former Summerlin-area movie theater
The gym, which will fill the old Regal Theater on 9400 W. Sahara Ave. in Summerlin, is set to open later this year or early next.
Business Leader Tim Giroux Announces Candidacy for Nevada Joint Union High School District Trustee
GRASS VALLEY, Calif. – June 26, 2026 – Tim Giroux, a business leader and community member rooted in the Auburn/Grass Valley area since 1999, today announced his candidacy for Trustee of the Nevada Joint Union High School District. The election will be held in November 2026. Giroux brings more than 40 years of business ownership […]
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Twin City Entertainment collaboration to host the Carol Burrnett Show in West Monroe June 27th
WEST MONROE, La. (KTVE/KARD) — Residents in the West Monroe area will have the chance to enjoy a night of laughter later this week as a live stage production inspired by The Carol Burnett Sho…
Travelers Championship brings business boost and traffic headaches for Cromwell-area shops
As golfers compete at the Travelers Championship, nearby restaurants and shops in the Cromwell area are seeing the tournament’s impact on business, with some owners welcoming the crowds and others pointing to traffic challenges.
Winter Sports Club to raise Olympian banners July 3 at Olympian Hall
The Steamboat Springs Winter Sports Club will raise banners to the rafters of Olympian Hall at Howelsen Hill to honor the area’s most recent Olympians. The event will take place from 4-5:30 p.m. on July...
Jimmy Butler shares ACL rehab update, expectations for Warriors next season
Jimmy Butler shared an encouraging update on his ACL injury rehab and his expectations for the Golden State Warriors in the 2026-27 NBA season.
Shockwave Medical announces new studies evaluating carotid IVL platform
Carotid artery disease causes up to 30% of all strokes, but severely calcified lesions can make treatment quite complex. The hope is that IVL can be as successful in this area as it has been in the treatment of coronary and peripheral artery disease.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
How many professional sports teams are in Austin?
With all the buzz around bringing more professional sports teams to the metro area, it’s worth considering how many are already here.
Politics | Local, California, U.S. & World Politics
ABC7 News covers local, California, U.S and world politics like no one else in the San Francisco area. KGO is your source for political races and legislation.
13 things to do this weekend around the Seattle area
From the Seattle Pride Parade to new art gallery exhibitions, here are the latest local things to do around the Seattle area.
13 things to do this weekend around the Seattle area
From the Seattle Pride Parade to new art gallery exhibitions, here are the latest local things to do around the Seattle area.
Rogers Computer Science Teacher Named Tops in the State
Instructor and coach, Anthony Hanos with members of the cyber security program, students Brandon Wilson, Kerian Santiago and Alex Bettencourt. The sister sectors of computer science, information technology and cybersecurity, continue to be among the fastest growing industries in the country, according to the U.S. Bureau of Labor Statistics. Luckily, Newport area high schoolers interested
New program aims to bring more business to downtown Buffalo
The initiative will provide grant money to allow local groups and businesses to host community focused events in the downtown area.
York County restaurants scrambling for bread after bakery's closure
Terranetti's Italian Bakery in the Mechanicsburg area closed suddenly after 54 years, leaving York County restaurants scrambling for bread.
Europe's heatwave shifts east as as France raises health alert to highest level
Temperatures in Germany could hit 40C in some areas while French officials say deaths linked to the heat are being seen among young people.
Memphis People in Business for June 25, 2026
A look at promotions, hirings, movers and newsmakers in the Memphis area business scene
In wake of homicide on Tyler Street, nearby business owners reaffirm faith in community
In the aftermath of last week’s homicide on Tyler Street, local business owners in the area told The Eagle that the incident is not representative of the neighborhood’s character.
Amherst Chamber of Commerce hosts annual Business Expo
The 5th annual Amherst Area Chamber of Commerce Business Expo was held tonight in the Amherst area, providing a venue for businesses to connect with community members.
Liverpool signs find a way to support business
EAST LIVERPOOL-As part of the revitalization process for the historic downtown area in East Liverpool, two wayfinding signs have just been installed in the downtown area to help direct people walking through downtown to businesses located in the area. The wayfinding signs, which have smaller directional signs on them pointing out the locations of multiple […]
The NHL Is Considering Bringing More Teams to Texas
The NHL has expanded to new areas in recent years, as the North American hockey league has brought teams to Las Vegas, Utah and Seattle. More expansion could be coming. But while hockey is known for its footprint in northern U.S. states and Canada, the league is considering bringing more of it to ...
Fort Lauderdale hopes "Uptown Urban Village" could bring extra business to the area
Potential vote could change alcohol rules in Bardstown Road entertainment district
A political effort is underway that could put the liquor status of the Bardstown Road entertainment district on the ballot this fall, a move that could bring major changes to businesses in the area.
Politics | Local, California, U.S & World Politics
ABC7 News covers local, California, U.S and world politics like no one else in the Los Angeles area. KABC is your source for local political races.
Moved to Minneapolis for work; why I love living here
I moved from the Bay Area to Minneapolis for work. Although I didn't know anyone in the city, I've quickly grown to love the vibrant community.
Scene Calendar: Local theater, fine arts, 'Free Fridays,' comics and more
A comprehensive list of Gainesville-area entertainment events.
Bigger trade now an option after Sharks deal William Eklund for No. 9 draft pick
San Jose Hockey Now's Sheng Peng dissects what could be next for the Sharks after they acquired another top-10 draft pick for William Eklund.
Highlights: Greater Lansing Area Sports Hall of Fame All-Star Softball Games
It was at Ranney Park on Tuesday evening.
Giants' Buster Posey has stern one-word response to possible Logan Webb trade
San Francisco Giants president of baseball operations Buster Posey addressed potentially trading star pitcher Logan Webb.
Santa Cruz County business filings: Week of June 23
Businesses operating in Santa Cruz County must register with the county clerk. Lookout Santa Cruz reviews the public filings from local businesses to report on new businesses starting in the area.
What they're saying about five frontcourt Warriors prospects in 2026 NBA Draft
Here are some pros and cons of five frontcourt players the Golden State Warriors have evaluated ahead of the 2026 NBA Draft.
Interstellar Arc wins “Best Location-Based Entertainment” at prestigious Auggie Awards
LAS VEGAS — Interstellar Arc at AREA15, the awe-inspiring, visionary experience from the Emmy®-winning creators at Felix & Paul Studios, announces it has been awarded “Best Location-Based Enter…
Euro-Zone Business Activity Shows Resilience to Iran War Fallout
Business activity in the euro area shrank less than anticipated in June, feeding optimism that the region’s economy can weather faster inflation and the jolt to confidence dealt by the Iran war.
Four students head to Pittsburgh to learn key professional skills as John R. Lewis Undergraduate Public Health Scholars
The UT San Antonio students will spend eight weeks this summer in classroom-based and experiential learning experiences at the University of Pittsburgh School of Public Health and area internships.
A Sweet End: Baton Rouge area bakery to close after years in business
A bakery in East Baton Rouge Parish is set to close this summer after its owners said they are pursuing careers that will allow them to spend more time with family.
A spider new to science got an Oregon naming ceremony, and locals helped choose its name
The name means "cave spider" in Sahaptin, the Native language traditionally spoken in the area where the spider was discovered.
Dalton and Tristi's NBA mock draft 4.0: Who Warriors, Kings pick in first round
NBC Sports Bay Area and California predicts who the Golden State Warriors and Sacramento Kings will pick in the 2026 NBA Draft's first round.