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Latest stats show stress and lack of physical activity are rising, putting heart health at risk
As people navigate higher levels of stress and spend more of their day sitting, finding time to move can feel challenging. Less than half of adults and fewer than one in five children in the U.S. get ...
Fall River's Day of Portugal announces dates, entertainment lineup for 2026
A festival that brings food, faith, and entertainment to the city will be returning once again. Day of Portugal Fall River, which takes place every year at the Gates of the City down near the waterfront on Ponta Delgada Blvd., is back in 2026. One of the more popular events in Fall River which
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
'Everybody Loses' author discusses the meteoric rise of sports gambling
Two years ago, Americans bet $120 billion on sports, a 27% increase from the previous year. That figure grew to $150 billion in 2024. Journalist Danny Funt investigates what's considered one of the most consequential — and least scrutinized — shifts in modern American sports in his new book, "Everybody Loses: The Tumultuous Rise of American Sports Gambling."
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
White House navigates vaccine politics, midterm risks in CDC director search
The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.
See what students from New Hampstead High wore for their 2026 prom
Students from New Hampstead celebrate their 2026 high school prom at Red Gate Farms.
Top business aviation banker talks debt, profits, JetGate, EBITDAR
Jefferies' Nick Fazioli on why Wall Street loves private jets, non-GAAP financial metrics and why past results don't preclude more investment
Health insurance jargon can be frustrating and confusing – here’s how to navigate it
What plan you pick has a huge impact on what you will end up paying.
Ancient DNA reveals a farming shift that pushed a society to the brink
A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.
US health department investigates 13 states that require insurance plans to cover abortion
HHS is looking into the states for ‘alleged disregard of, or confusion about’ the federal Weldon amendment
Who Should Be England’s Number 10 at the World Cup?
The 2026 FIFA World Cup is fast approaching, and England manager Thomas Tuchel has some huge decisions to make. Former boss Gareth Southgate came in for major criticism from supporters for continually...
The Big Dance brings action to Downtown St. Louis, as city leaders move to finalize sports and entertainment district
St. Louis is feeling March Madness. It’s not just the games taking place on the court in the Gateway City; the Saint Louis University men’s basketball team drew many eyes Thursday night as the Billikens faced Georgia in the NCAA tournament.
The Big Dance brings action to Downtown St. Louis, as city leaders move to finalize sports and entertainment district
St. Louis is feeling March Madness. It’s not just the games taking place on the court in the Gateway City; the Saint Louis University men’s basketball team drew many eyes Thursday night as the Billikens faced Georgia in the NCAA tournament.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Humans and animals have the same preference in mating calls, citizen science experiment finds
The bright colors of butterfly wings, the sweet aromas of flowers, and the euphonious melodies of songbirds all evolved as signals that help individuals propagate, yet humans also find these very same ...
HHS’ Office for Civil Rights Investigates Thirteen States Under Federal Conscience Law
HHS today announced investigations of thirteen states under a federal health care conscience law—the Weldon Amendment.
Oz Says California’s Not Fighting Health Care Fraud, but Data Shows It’s Part of a Larger Battle
Trump administration officials say the state allows rampant fraud and have promised to investigate, blaming the “Russian, Armenian mafia” in the hospice and home health care industry. But data shows hotbeds of health care fraud throughout the country, with California outperforming most other states in recovering fraud dollars.
Benidorm's champion 'opening gate' for MMA in Spain
Home favourite Costello van Steenis defends his PFL middleweight title against Britain's Fabian Edwards in Madrid on Friday in the largest MMA event to ever take place in Spain.
F.B.I. Investigates Joe Kent, Whose Resignation Over Iran War Angered Trump
Mr. Kent is under investigation for a possible intelligence leak, according to people familiar with the situation. The inquiry is said to predate his resignation this week as the top U.S. counterterrorism official.
Lawmakers’ health care fraud clash
On Tuesday, Republicans and Democrats on a key House committee sparred over GOP efforts to investigate Medicaid fraud.
What to know about Bill Gates’ nuclear science company planned for the former South Philadelphia refinery site
TerraPower Isotopes will manufacture a rare, radioactive isotope for use in developing cancer treatments.
XOMA Royalty Reports 2025 Financial Results and Highlights Recent Business Achievements
Portfolio receipts: • Achieved over $50 million of cash receipts, including $33.6 million in royalties and $16.9 million milestones, in full year 2025 • Total receipts increased 9% with royalties up 68% versus full year 2024 Business development: Added 22 assets to portfolio, including five programs in Phase 2 or Phase 3 development Stock buyback program: Repurchased and retired 648,048 shares for an aggregate of $16.0 million Company acquisitions: Completed seven acquisitions, accumulating $11.
Number of meningitis cases investigated in Kent rises to 20
Figure up from 15, says UK Health Security Agency, as thousands of students to be offered vaccines in coming days
Ali Larijani, a Top Iranian Politician and Emissary, Is Dead at 67
Mr. Larijani, the top national security official and a confidante of the former supreme leader, expertly navigated Iran’s internal politics and led the brutal crackdown on protests this year.
The “populist” crusade to make the suburbs more segregated and expensive
The crackdown on corporate landlords just got more counterproductive.
A Massive Midterm Wave Isn’t Forming Yet. Here’s Why.
This is an era not just of hyperpartisanship, but of negative partisanship, in which partisans often hate the other side even more than they love their own. Many voters thus tend to see everything on a binary basis. Any given election outcome is seen as either a landslide victory or an unmitigated disaster. There is little appreciation, or even tolerance, for gradations between those outcomes.
Public Health: Gastrointestinal illness outbreak associated with 13 Coins
King County Public Health says they investigated a gastrointestinal illness outbreak associated with the 13 Coins restaurant in SeaTac.
UPMC warns embattled data exchange Health Gorilla may have improperly pulled patient records
UPMC says its medical records may have been improperly accessed by Health Gorilla, a patient data gatekeeper accused in federal court of mismanaging sensitive information. Health Gorilla requested data “under the pretext of providing treatment to shared UPMC patients and claimed it had permission to do so,” according to a
Health officials investigate E. coli outbreak linked to raw cheese sold in Florida
Health officials are investigating an outbreak of E. coli in multiple states, including Florida, that appears to be linked to raw cheese products.
Healthy ageing in Singapore: why health literacy matters
As Singapore becomes a “super-ageing” society, health literacy is key to helping older adults navigate care, stay healthy and remain socially connected. Explore the policies and initiatives supporting healthy ageing.
Minister plays down Trump’s Nato threat, arguing US alliance strong enough to ‘outlast’ current issues
Pat McFadden says Trump running a ‘transactional presidency’ and that ‘our job is to navigate this’
Low-cost preventive measures could mitigate spread of bacteria causing neonatal mortality
A new study found that a multifaceted infection prevention and control intervention could at least temporarily thwart outbreaks of infections from the Klebsiella pneumoniae bacterium, a leading cause ...
DeGette challenger Melat Kiros trounces 15-term Democratic incumbent in Denver delegate vote
The 28-year-old, first-time candidate challenging Democratic U.S. Rep. Diana DeGette in this year’s primary soundly defeated the 15-term incumbent in a delegate preference poll conducted Saturday at a county party assembly in Denver. Melat Kiros, the daughter of Ethiopian immigrants and a former corporate attorney, received nearly twice as many votes as DeGette in a […]
Army veterans Jessica Killin, Joe Reagan qualify for Democratic primary ballot in Colorado’s 5th CD
Democratic congressional candidates Jessica Killin and Joe Reagan secured spots Saturday in Colorado’s June primary to decide who will run against Republican U.S. Rep. Jeff Crank in a district that’s only ever sent GOP lawmakers to Congress. The two Democrats, however, told delegates at the party’s nominating assembly in Colorado Springs that the 5th Congressional […]
Deputies evacuate Destin Commons area after bomb threat called into business
OKALOOSA COUNTY, Fla. -- Deputies are urging people to avoid the Destin Commons area as deputies investigated a bomb threat called into a business.Deputies were
Pols & Politics: Campbell, DiZoglio to share the stage at St. Patrick’s Day breakfast amid audit battle
Attorney General Andrea Campbell and state Auditor Diana DIZoglio will be sharing the stage, and perhaps some obligated playful banter, during the annual St. Patrick’s Day breakfast on Sunday.
Army veterans Jessica Killin, Joe Reagan qualify for Democratic primary ballot in Colorado’s 5th CD
Democratic congressional candidates Jessica Killin and Joe Reagan secured spots Saturday in Colorado’s June primary to decide who will run against Republican U.S. Rep. Jeff Crank in a district that’s only ever sent GOP lawmakers to Congress. The two Democrats, however, told delegates at the party’s nominating assembly in Colorado Springs that the 5th Congressional […]
Christ Hospital Health Network expands women's care with new Greater Cincinnati site
The 4,551-square-foot facility is scheduled to begin seeing patients March 16.
Universities slow hiring, faculty navigate rocky future amid Trump attacks on higher education
The Trump administration’s attacks on universities have led to a slowdown in hiring, with international academics particularly caught in the crossfire. Colleges are being forced to navigate b…
Evidence mounts suggesting health costs from WV lawmaker moves on data centers, water
In a span of less than half an hour March 12, 2026, the West Virginia House of Delegates made three moves undermining the state’s already poor drinking water quality. Moves the House of Delegates and Senate have made in the 2026 legislative session's final days are likely to inflict significant health costs, recent studies suggest.
4 Security Plaza Shopping Center businesses burglarized
Baltimore County police are investigating four break-ins at businesses in Woodlawn.
Microsoft’s New Healthcare Chatbot, an Aneurysm as a Gateway for Romantasy and the Decline of Male Therapists | WSJ Health for March 13
Plus, how an aneurysm led to a love of romantasy and a look at the decline of male therapists
Google just gave Gemini the power to control apps on the Galaxy S26 — and it's pretty wild
The new feature lets Gemini order food, book rides, and navigate apps for you.
Chain favorite replacing Wawa at Trexler Business Center in Lower Macungie
Qdoba Mexican Eats is launching its third location in the Lehigh Valley, operating by the same group running the Whitehall and Westgate Mall sites.
Wall St whisperers help financial firms navigate Iran conflict risks
The day before U.S.-Israeli air strikes killed Iran's Supreme Leader on Saturday February 28, many Wall Street firms were expecting military action thanks to a growing industry of ex-military and national security advisors who were warning the signs were clear.
Nessel vows to continue antitrust case against Live Nation for monopolizing live entertainment industry
LANSING – On Monday, following the announcement of a settlement reached between Live Nation and the U.S. Department of Justice to resolve antitrust claims brought by the federal authority alongside a broad, bipartisan coalition of states, Attorney General Nessel and the multistate coalition have resolved not to join the settlement and instead continue to litigate […]
Student Led Service Group Helps Refugees Navigate Healthcare System
UW Medical Students Helps Refugees Navigate Healthcare System
Celebrate STEAM Launches Atlanta Science Festival
To kick off the 13th annual Atlanta Science Festival (ASF), Georgia Tech hosted Celebrate STEAM on March 7, welcoming thousands of visitors to experience hands-on demonstrations and interactive displays showcasing the innovation and excitement at the intersection of science, technology, engineering, and mathematics.
CERN Science Gateway celebrates its 1000th science show
CERN Science Gateway has reached another milestone: the delivery of its 1000th science show! Since opening its doors in October 2023, Science Gateway has welcomed nearly 900 000 visitors of all ages to explore the fundamental questions of the Universe. Among its most popular activities are the science shows – dynamic, interactive demonstrations led by CERN guides and tailored to a broad audience of different age levels, including school groups, families and the general public. Designed to make complex scientific concepts accessible and entertaining, these live shows combine spectacular experiments, multimedia elements and audience participation. From the physics of particle collisions to the properties of superconductivity, electromagnetism and cryogenics, the science shows translate the research carried out at CERN into engaging visual experiences. Visitors might see superconductors levitate, follow particles through different detector layers or discover the beauty in phase transitions. Each demonstration is carefully crafted to spark curiosity while maintaining scientific accuracy. Members of the CERN community are of course warmly invited to visit CERN Science Gateway with their family or friends and attend one of the science shows. To register, please visit this page, and don’t forget to check the programme for the coming days. Become a CERN guide and run your own super-cool science show (and more)! To become a CERN guide, you can join the introduction course held every 3–4 weeks, which will give you an overview of what being a CERN guide entails. From there, further courses are available depending on what type of guide you would like to be. Because, of course, CERN guides are needed everywhere at CERN. If you imagine yourself as a more ‘traditional’ guide, you should know that there are currently more than ten exciting visit points in CERN’s visits portfolio, such as the Antimatter Factory, the ALICE experiment (surface), the Alpha Magnetic Spectrometer (AMS) control room, the ATLAS experiment (surface), the CERN Control Centre (CCC), the Data Centre, the LHCb experiment (surface), the Synchrocyclotron (SC), the SM18 test facility and the newly inaugurated Linac2 visit point. Indeed, CERN’s Visits Service and Visual Impact and Exhibitions Section recently collaborated on redesigning the Linac2 visit tour, which has just reopened to the public after several months of renovation work. The new tour offers visitors and guides alike an enriched, more immersive experience, designed to highlight the history and scientific significance of this major facility. So, fancy becoming one of the insiders? Join the introduction course, check the guides website or contact guides.manager@cern.ch. And remember, becoming a guide can benefit you, too.
In Talking to Parents About Vaccines, Pediatricians Navigate a Sea of Misinformation
Practitioners nationwide are striving to do what’s best for children’s health, while staying supportive in the face of mistrust and confusion.
Shreveport sets new tax for film and entertainment district
(The Center Square) – Shreveport is poised to add a 2% sales tax and 2% hotel occupancy tax in the city's new Film and Entertainment Gateway Economic Development District.
Scoop: Mountaingate to sell Relevate Health
Relevate is part of a cadre of sponsor-backed marketing and engagement businesses that could be due for a trade.
How Much of Science Is Fake?
For decades, scientists were above reproach. Not any more. Joe Nocera investigates the murky world of fraudulent research, and the sleuths exposing dishonest science.
Colorado health officials navigate measles outbreak that started at Broomfield High School
Shreveport council approves new film and entertainment district taxes
SHREVEPORT, La. — The Shreveport City Council approved a resolution Monday establishing the Film and Entertainment Gateway Economic Development District to fund local construction and development projects.
Chicago Divorce Attorneys Molly E. Caesar and Michael Ian Bender Explain Business Valuation Methods in Illinois Divorce Cases
CHICAGO, IL - Business owners facing divorce in Illinois must navigate complex valuation issues to determine how
U.S. and Israeli war in Iran, which Trump says will be 'short term,' has global reach
In less than two weeks, the Trump administration has instigated a truly global conflict, and with no clear path to resolution.
Alexander Butterfield, Who Revealed Nixon Tapes in Watergate Scandal, Dies at 99
“There is tape in the Oval Office,” said Mr. Butterfield, a former White House aide, in testimony that rocked the Watergate hearings and led to the president’s resignation.
Union Pride and Politics on Hand at Indiana State Council
Members of the IAM Executive Council traveled to Indianapolis for the Indiana State Council conference and encouraged delegates who are the statewide legislative arm of the union.
Pokémon Pokopia has only just released, but players are already starting to figure out Minecraft-like automatic builds and logic gates
Pokémon Pokopia players are starting to figure out automatic builds that remind us of Minecraft's humble beginnings.
Trails in the Sky 2nd Chapter details main characters
Falcom has opened the official website for Trails in the Sky 2nd Chapter, introducing main characters Estelle Bright, Joshua Astray, Scherazard Harvey, Olivier Lenheim, Agate Crosner, Kloe Rinz, Ti…
The Iran War Is Giving Democrats a Chance. Will They Take It?
Last week, Republicans in Congress rejected a war powers resolution and thus negated their own power. In so doing, they gave President Donald Trump free rein over the Iran conflict and tied themselves to a war that has no consistent justification, no clear end and little public support. Democrats voted largely in lockstep to curtail Trump’s power, the first move in a process that will become more substantial as the already-unpopular war continues. History shows that foreign conflicts rarely get
Apple's entry-level M5 SoC in the MacBook Air 13 only consumes 7-8 Watts in games like Cyberpunk 2077 or Baldur's Gate 3
Apple's new MacBook Air with the small M5 SoC is extremely efficient while gaming. During our tests, we recorded a SoC consumption of just 7-8 Watts, which means the gaming performance is also rock solid despite the passive cooling solution.
Oil change business closes due to theft by multiple employees: South Euclid Police Blotter
The Take 5 Oil Change temporarily closed Feb. 26 so that a theft by multiple employees could be investigated.
Big Tech’s Uncertain Future in the Persian Gulf
The expanding war in the Middle East has added new risks to the trillions of dollars in investments that tech companies have planned in the region.
After week of war and political upheaval, Trump remains defiant as ever
In the last week, Trump has instigated or been forced to navigate a stunning cascade of political threats, but has remained defiant, sounding more unbothered than embattled.
Ig Nobel: Inside the World of Science That Makes People Laugh
Through the lens of Ig Nobel prizes, Upasana Sarraju investigates why society elevates some scientific questions while sidelining others in a new book.
Senator Blumenthal Pushes to Investigate Kristi Noem for Perjury
Senator Richard Blumenthal of Connecticut said Democrats had evidence to suggest Kristi Noem lied under oath during a Senate hearing on Tuesday.
These tiny swimming robots can navigate 'artificial space-time' mazes using Einstein's relativity
The tiny bots follow patterns of light and "artificial space-time," navigating like craft following the curved space around a black hole.
Police investigate shooting at Family HealthCare Network clinic in Central Fresno
Fresno police are investigating a shooting at the Family HealthCare Network off Clinton and West avenues in Central Fresno.
3L Kevin Afiesh Learns to Translate Legal Risk Into Business Strategy as FinTech Extern - UC Law San Francisco (Formerly UC Hastings)
3L Kevin Afiesh strengthened his corporate and fintech skillset through an externship at Plaid, gaining real-world experience at the intersection of technology and financial services. 3L student Kevin Afiesh shares how UC Law San Francisco’s Corporate Counsel Externship provided immersive, practice-ready training inside Plaid’s in-house legal department. Reviewed and analyzed technology-focused agreements, including emerging AI provisions and liability terms Explored financial services regulation and data governance within a growth-stage company Learned how internal legal teams shape product, partnership, and compliance planning 3L student Kevin Afiesh: During my externship at Plaid, I worked with the in-house legal team supporting a rapidly growing company at the intersection of technology and financial services. My work focused primarily on corporate, commercial, and intellectual property matters. I helped review and analyze vendor and partnership agreements, paying close attention to emerging artificial intelligence-related provisions and risk allocation terms. I also investigated regulatory and compliance issues involving financial services and data governance, and I researched intellectual property litigation relevant to fintech companies. This work supported legal risk assessment to guide strategic decision making. I learned firsthand how an in-house legal team operates in a highly regulated, innovation-driven environment, where legal analysis is closely integrated with business decision making. I saw how attorneys balance legal risk with commercial priorities and how their advice shapes contracting, compliance, and intellectual property strategy. It reinforced that effective in-house lawyers need to understand both the law and the operational realities of the business. The experience also strengthened my ability to communicate complex legal concepts clearly to non-lawyers and to provide advice that is precise, practical, and commercially aware. Throughout my academic and professional journey, I’ve worked with technology companies at different stages. Plaid added a distinct perspective within the tech ecosystem, showing me how a growth-stage fintech company approaches regulatory complexity, innovation, and risk tolerance. This sharpened my ability to adapt to clients with different structures, priorities, and compliance needs. As I prepare to practice corporate law in the technology industry, this exposure has strengthened my ability to align legal advice with a company’s stage of growth, strategic objectives, and internal dynamics. I would absolutely recommend the Corporate Counsel Externship Program. Working directly with an in-house legal team provided a meaningful sense of day-to-day practice inside a technology company, and the attorneys at Plaid were generous with their time and mentorship. The classroom component was equally valuable. Professors Nira Geevargis and Scott Darling created a thoughtful environment where we reflected on our experiences, discussed real-world challenges, and developed practical skills that complemented our fieldwork. More broadly, UC Law San Francisco’s location offers a clear advantage for students interested in technology, corporate practice, and public-interest work. Proximity to courts, law firms, and innovative companies — combined with programs like the Corporate Counsel Externship and an extensive Bay Area alumni network — make it a strong option for students who want to build their careers in the region. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
'Sprinklergate' football club hires new boss
Non-league King's Lynn Town replaces Ian Culverhouse and appoints Paul Caddis as head coach.
Virginia health officials investigate potential measures exposure in Lynchburg
The patient is a resident of another state who recently traveled internationally.
House ethics panel investigates GOP Rep. Gonzales of Texas over affair allegations
The House Ethics Committee said Wednesday that it has opened an investigation of Rep. Tony Gonzales, R-Texas, over allegations that include having an affair with an aide.
Christina Applegate Reveals Why She Dumped Brad Pitt In '89 — And We Are Shocked
Her decision is sure to make you frown.
NASA Anomaly Review Board Investigates MAVEN Loss of Signal
A NASA anomaly review board, convened in mid-February, is evaluating the recovery efforts undertaken for the agency’s MAVEN (Mars Atmosphere and Volatile
Gaslight, Gatekeep, Girlboss: Pay and Leadership Gaps for Women in Public Health
Women in government public health face a persistent leadership and salary gap. Here's what the data shows — and what the field must do to close it.
Spotlite: On the Hunt for Magnetic Metals
In this NASA Spotlite, NASA interns investigate the misconception that all metals are attracted to magnets. Through a hands-on experiment, they test different
Christina Applegate knew her marriage to Johnathon Schaech was doomed at the wedding: 'This man was not for me'
In her new memoirm 'You With the Sad Eyes,' Christina Applegate looks back on her first marriage to Johnathon Schaech: 'If you go on a first date with a guy and you don't like his shoes, run.'
Christina Applegate recalls losing her virginity at 16 while playing promiscuous teen on 'Married With Children'
Former child star Christina Applegate reflects on her tumultuous rise to stardom in her new memoir and shares how vastly different her real-life experiences were from her onscreen life.
Laid-off Block staff commiserate in 'Square Mafia'
Former Block employees congregate in an unaffiliated Slack group to share support, find new jobs, and trade memes. It's grown since recent layoffs.
Report: Apple Asks Google to Run Siri on Its Servers
Apple has asked Google to investigate setting up servers in its data centers to run a future version of Siri powered by Gemini, The Information reports. Currently, Apple sends its more complex AI queries to Private Cloud Compute, a system that runs on Apple servers using Apple silicon chips. Today, only 10% of Apple's Private Cloud Compute capacity is said to be in use on average.
Celebrate STEAM to Launch 2026 Atlanta Science Festival
To kick off the 13th annual Atlanta Science Festival, Georgia Tech will host its Celebrate STEAM event on March 7. Free and open to all, the event invites visitors to campus for hands-on demonstrations and experiences showcasing the innovation and excitement at the intersection of science, technology, engineering, and mathematics.
Science of fitting in: Do best friends or popular peers shape teen behavior?
As kids enter adolescence, peer influence splits in two—often in ways adults miss. Following 543 middle schoolers for one semester, researchers found that best friends shape teens’ inner lives, from emotional struggles to academic challenges, while popular peers influence public, status-driven behaviors like social media use and weight concerns. Far from being easily swayed, adolescents navigate peer influence strategically—an insight frequently overlooked by parents and educators.
Shooting outside Austin bar leaves 3 dead and 14 injured, FBI investigates possibility of terrorism
A gunman opened fire outside a bar in a popular entertainment district in the Texas capital of Austin, killing two people early Sunday in a shooting that the FBI said is being investigated as a potential act of terrorism.
Labour minister Josh Simons resigns after falsely linking journalists to ‘pro-Kremlin’ network
Makerfield MP has been under pressure over thinktank’s commissioning of PR firm to investigate reporters
AI, Ethics and Business Collide in Anthropic’s Standoff with the Pentagon
Marc Ruggiano, director of Darden’s LaCross Institute for Ethical Artificial Intelligence in Business and a navy veteran, shares his insights on the clash between Anthropic and the Pentagon and explains how Darden teaches students to navigate the often choppy waters of business, ethics and technology.
Fastest 5 Minutes: Audits of Federal Small Business Program Awards
This episode addresses efforts by various federal government agencies to audit and investigate purported ‘waste, fraud, and abuse’ in small business set-aside awards, and is hosted by Yuan Zhou,…
Presidential hopefuls and protests at GAA Congress
Croke Park is the venue this weekend as GAA delegates gather for the 2026 Congress with some key issues to be decided including the election of a new president.
FBI investigates possible HazMat situation at homemade science lab in Irvine
The landlord at the home in a gated community called Irvine police to alert them to the suspicious items. The OCFA requested help from the FBI.
How will British history remember this political scandal?
Fresh revelations can initially seem bigger than past indiscretions, from Partygate to MPs’ expenses
Pam Legate to relocate Owensboro naturopathic practice after TJ Regional Health acquisition
Pam Legate, a longtime naturopathic practitioner serving Owensboro, is relocating her practice to Smiths Grove after TJ Regional Health acquired her business and brought her services under its medical system.
Butler's 15 help Lafayette defeat Colgate 70-69
HAMILTON, N.Y. (AP) Mark Butler had 15 points in Lafayette's 70-69 victory over Colgate on Wednesday.
25th Navajo Nation Council
Delegate Johnson applauds Navajo Pine students’ innovation at science fair NAVAJO, N.M. –Council Delegate Casey Allen Johnson recently demonstrated his support for science, technology, engineering,...
Hiring vs. contracting becomes a high-stakes business decision
As companies navigate growth, uncertainty and rising labor costs, deciding between hiring an employee or engaging an independent contractor has become a strategic choice, not just an HR one, Fast Company writes. A panel of executives outlines 14 considerations, from whether the work is core and ongoing or project-based and time-bound. The guidance centers on […]
Open science accelerates women’s health innovation globally
SGC-UNC, with support from the Gates Foundation, is working on developing a nonhormonal contraceptive.
Open science accelerates women’s health innovation globally
SGC-UNC, with support from the Gates Foundation, is working on developing a nonhormonal contraceptive.
Charleston businesses say city is 'a little too late' addressing downtown development fallout
Charleston’s small business owners say the city isn’t doing enough to help mitigate the negative impact two major downtown developments have caused.
Champions League Preview: Juventus vs. Galatasaray
Juventus face a monumental task of trying to reverse a 5-2 aggregate scoreline that was a lot of their own doing in Wednesday night’s second leg against Galatasaray.