SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " find " 6,053 found 🔀 AI-powered Shuffle
NFIB reports slight dip in small business optimism
Owners cite weaker sales, inflation and supply chain strains, while many still struggle to find qualified workers.
FLEX Finder Week 1: Where to find value before roles take shape
Rivers McCown comes up with a list of players he hopes will defy their low cost to be fantasy football heroes for Week 1.
Business Beat : Tibbits welcomes back the neon tinged ’80s music experience of ‘The 1985’
COLDWATER, MI (WTVB) - Music lovers are invited to dig deep into their closets and find their vintage 1980's f...
Scientists Who Study Sleep and Narcolepsy Win Prestigious Lasker Award
The two researchers have won a prestigious Lasker Award. Their findings laid the groundwork for a new drug that addresses the sleep disorder’s root cause.
Scientists find a bone-building switch that could fight osteoporosis
An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.
Mental health survey finds Yampa Valley residents struggle with loneliness, substance use disorders
The Steamboat Springs City Council heard a sobering assessment of behavioral health in the Yampa Valley on Tuesday: Despite strong awareness of local resources and a reputation for community support, many residents still face loneliness,...
Findhelp Partners With Maryland Health Care Commission as the First Specialty Exchange to Advance Social Care Interoperability
/PRNewswire/ -- Findhelp, the nation's leading social care technology platform, today announced it is the first specialty exchange that has registered with the...
Findhelp Partners With Maryland Health Care Commission as the First Specialty Exchange to Advance Social Care Interoperability
Findhelp, the nation's leading social care technology platform, today announced it is the first specialty exchange that has registered with the Maryland Health Care Commission (MHCC).
Arbeloa needs 'positive support' but defence is 'comical'
Rohan: I feel as though Arbeloa has completely underestimated the physicality of the Premier League. Without signing another centre-back as a partner for Calvin Bassey, he has allowed other players to breach the right of our defence easily. Arbeloa needs to find a way to counter this so we can start picking up points.
Hiltzik: Resisting Trump turns out to be a winning business strategy
A study finds that businesses that resisted Trump's anti-diversity pressure paid no price. Are the law firms and universities that capitulated listening?
Mistrust of US government information is rising across major issues, new poll shows
A new AP-NORC/USA Facts poll finds that Americans are more skeptical of government information than they were a few years ago, with majorities now saying they have little or no trust in federal government information about elections, foreign affairs or the environment.
These are the best things to do in Brevard this weekend, Sept. 11-17
Find your weekend adventure! Zoo days, live music and theater auditions top our list of Brevard's best things to do.
Cancer’s toll on 9/11 survivors is accelerating 25 years later
The number of victims receiving aid has tripled in recent years, a Post analysis finds, as the illness’s toll becomes more apparent.
Did New Film Unit Just Shift AMC Stock’s Investment Narrative?
AMC Entertainment Holdings recently launched Leawood Films, a film distribution unit based in Los Angeles and Leawood, Kansas, aiming to bring more small and mid-sized movies into theatres worldwide while relying on fully financed projects to limit production risk. The new distributor uses AMC’s excess screen capacity and past concert-film marketing experience to secure theatrical placement for filmmakers who might otherwise struggle to find backing, while leaving most downstream revenue and...
Scientists and algorithms: Finding the right balance in modern drug development
The future of drug development is not scientists versus algorithms. It is scientists and algorithms working together.
Europeans struggle to imagine 'credible' future, study finds
New research identifies an 'imagination gap' as where political choices can still matter
Europeans struggle to imagine 'credible' future, finds study
New research identifies an 'imagination gap' as where political choices can still matter
Signs of US-style polarisation in Britons’ trust in science
Sense of shared identity makes Greens’ faith in scientists stronger than Reform voters’, study finds
50 countries and counting, she now finds value in slow travel
Social media made travel feel like a competition. Seeing country counts in people's bios made Macie Strum start keeping score.
Study Findings Conflict with Body of Science Linking Pesticides to Attention Deficits and Autism - Beyond Pesticides Daily News Blog
A recent study finds no connection between levels of urinary biomarkers of organophosphates and autism-related traits, conflicting with a wide body of research.
Altour's Boult: Rising Travel Costs a 'Permanent Phenomenon'
Travel costs will continue rising into 2027, though more slowly than earlier this year, according to the annual GBTA-Altour forecast. Altour chief commercial officer Michael Boult spoke with BTN's Michael B. Baker about the findings, why travel buyers should expect little relief from higher prices in the near term, and why policy might not be the answer.
Former Celtics Forward Finds New Team After Boston’s Roster Overhaul
A former Celtics forward has found a new team after Boston’s offseason overhaul left him without a clear role. The post Former Celtics Forward Finds New Team After Boston’s Roster Overhaul appeared first on HEAVY.
Baylor finds confidence and belief despite loss to Auburn
WACO, Texas (FOX 44) — Baylor may have lost the battle on the scoreboard Saturday, but the Bears believe they gained something just as important in Atlanta: confidence. Despite a loss to Auburn, Baylor players said the game showed the team’s growing chemistry, physicality and belief heading into the rest of the season. Fifth-year cornerback […]
Dan Lanning's Ducks still not ready for college football's primetime
Oregon struggled to find consistency against Boise State to open the season.
Marlins' Brian Navarreto Finding Value Beyond Bat
Miami’s veteran backstop has endured a difficult offensive year while continuing to provide the Marlins with dependable work behind the plate and timely contributions.
Pirates Trying to Find This Balance With Konnor Griffin
The Pittsburgh Pirates need Konnor Griffin in the lineup, while also being mindful that he's still coming back from injury.
Chinese scientists find a hidden atomic structure that unlocks methane
Scientists found that a tiny atomic structure that forms on nickel oxide during methane conversion is more effective than the metallic nickel long believed to drive the reaction. The discovery allowed a low-nickel catalyst to rival one containing 10 times more metal, potentially opening the door to cheaper and more efficient industrial catalysts.
Menopause is missing from most electronic health records, study finds
Menopause is frequently missing from women's electronic health records, according to a University of Colorado Anschutz study of nearly 396,000 women participating in the National Institutes of Health's ...
A study links prenatal acetaminophen with reproductive changes in girls. Doctors say it remains safe to use when needed
A new study found that some girls born to mothers who took acetaminophen during pregnancy developed reproductive organ changes that could affect fertility later in life. It’s a finding the study authors say should drive future research but shouldn’t yet change how certain symptoms are treated during pregnancy.
Matos urges Vipotnik to find form of last season
Vitor Matos hopes Zan Vipotnik's goal in Swansea City's defeat at Southampton will spark a return to the form which earned him last season's Championship golden boot.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Alaska review finds potential financial disclosure issues involving 91 candidates
A preliminary Alaska Department of Law review found potential financial disclosure discrepancies involving 91 candidates, but did not determine whether any laws were violated.
Glendale Actress Finds Love of Science
A few years ago, Marilyn Heidecker was more likely to portray a criminalist on TV, film, or stage rather than work as an actual scientist who analyzes physical evidence in
Dripping Springs business owners advocate for wayfinding signs
New wayfinding signs and gateway monuments may soon be installed along Hwy. 290 following a 3-2 vote by the Dripping Springs City Council at a Sep. 1 meeting.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Texas’ Biggest Concern Going Into Saturday Is This
Texas has one of the most talented offenses in college football. But if the Longhorns want to finally beat Ohio State on Saturday night, they have to find a way to push the football down the field. That was a massive problem last year. Ohio State completely suffocated Texas’ passing game for most of its…
B2B Marketing Leaders Struggle to Prove Business Impact: 10Fold
10Fold research finds B2B leaders measure more than ever but struggle to connect metrics to revenue. See the communications ROI reset.
Study finds social, financial, and healthcare factors shape resilience in adults with sickle cell disease
A new study explores how individual and community health experiences of adults with Sickle Cell Disease (SCD) shape resilience — the capacity to adapt to adversity.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Florida business owner arrested after employees find hidden camera in bathroom: sheriff
NEW SMYRNA BEACH, Fla. (WFLA) — A Florida man was arrested on Monday after it was revealed that he hid a small camera inside an electrical outlet in the bathroom of his business. Donald Hemphill, 5…
Scientists Keep Finding the Same Mysterious Beat Across the Animal Kingdom, From Fireflies to Sea Lions
From fireflies to mammals, evolution may have tuned communication to the rhythm of neurons.
Joe Ryan Reflects On First Start Back From Injury
Although the 30-year-old right-hander was charged with the loss on Monday, he appears to be finding his rhythm again on the mound.
More evidence that mass shootings are suicidal acts
New research finds national peaks for suicides, gun rampages take place within days of each other in summer.
Methodist Health System Undergoes Wave of C-Suite Moves
Plus: Dude Perfect CEO steps away, new CFOs join Weitzman and Mission Critical Group, the Economic Club of Dallas finds a new executive director, and more.
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
NYC voters give Mamdani high marks, say mayor is doing better than expected
A new Suffolk University poll also finds New York voters disagree with GOP calls for Mayor Zohran Mamdani to stay away from 9/11 memorial.
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
New report finds little short-term health risk from air pollutants in South Portland, Portland
Six years of air sampling found benzene levels above state guidelines at one location and elevated acrolein levels across the study area.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Spirit Halloween stores are already open for the fall season. See southeast Louisiana locations.
As the fall season approaches, Spirit Halloween stores are popping up seemingly overnight. Here’s where to find the costume shop this year.
Vape waste poses risks to health and environment, analysis finds
Many disposable vapes contain extremely high levels of lead and other metals, raising new concerns over the fast‑growing piles of vape waste.
Brian and Ellen court danger once again in ‘Outlander: Blood of My Blood’ season 2 exclusive clip
Brian (Jamie Roy) and Ellen (Harriet Slater) find themselves in serious trouble in a clip from ‘Outlander: Blood of My Blood’ season 2 exclusive to ‘Entertainment Weekly.’
Myles Garrett expected to go for Rams on Thursday
Myles Garrett should be good to start the season, Van Jefferson finds a new home and more!
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Study Identifies Blind Spot In How Science Measures Breakthroughs
A new tool exposes how science's go-to metric misses breakthroughs made by two teams at once, from Darwin to particle physics.
Walking an extra 1,000 steps a day may help your heart, study finds
Here’s the latest science on how many steps you actually need every day.
Walking an extra 1,000 steps a day may help your heart, study finds
Here’s the latest science on how many steps you actually need every day.
APPLEGATE SHARES NEW FINDINGS ON OMEGA FATTY ACIDS THROUGH REGENERATIVE HEALTH INITIATIVE
/PRNewswire/ -- Applegate Farms, LLC, the maker of the nation's leading natural and organic meat brand, today shared new omega fatty acid findings from its...
Your personality may be more genetic than scientists realized
More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits. The findings reveal a surprisingly wide genetic connection between personality and life outcomes while showing that environment still plays a powerful role.
(BPRW) ProcuraFind® and Ally Financial Announce Strategic Initiative to Advance Small Business Growth Through Education, Readiness, and Opportunity
(Black PR Wire) Charlotte, N.C. — ProcuraFind® and Ally Financial announced a strategic, multi-year agreement focused on helping small businesses build stronger companies through education, financial empowerment, supplie...
NFL power rankings Week 1: Did a Super Bowl 60 teams miss top five?
As the 2026 NFL season kicks off, last year's two best teams already find themselves looking up at this year's apparent challengers.
McInnes vision becoming clear amid step in right direction
The past week or so has been faultless results-wise for Derek McInnes. It's a shame for Lawrence Shankland to facing a spell out injured after beginning to find form with three goals in two games. The transfer window overall was okay, but we can't be making bold statements on the back of three wins against teams Rangers should be beating.
‘Kick In The Face’: Hawaiʻi’s $2M Business Registration System Slammed
The Commerce Department has brought on additional staff and is working to find and fix bugs in the system.
California later school start times boost grades, sleep, study says
California middle and high school students report better mental health and grades with later start times, study finds.
Inhaled Microplastics Linked To Lung Cancer, Study Finds
By Dennis Thompson HealthDay ReporterTUESDAY, Sept. 8, 2026 (HealthDay News) — People with lung cancer are more likely to have hidden deposits of microplastics in their lungs, a new study says. About 66% of lung cancer patients had detectable microplastics found in fluid samples taken from their ...
ATT: Former Accenture consultant says consultants hate conflict
At Accenture, Lauren Bronson saw senior leaders struggle to confront toxic clients. Now, she helps leaders find common ground.
Fall River chiropractor finds fame on 'Love Island'. Now what?
Fall River native Chaten 'Chay' Nehra reflects on his 'Love Island USA' stint and his future plans for a bi-coastal medical career.
Amish families find uncommon ways to pay for healthcare
Amish communities avoid insurance, relying on mutual aid plans and cash to cover rising medical costs.
Amish families find uncommon ways to pay for healthcare
Amish communities avoid insurance, relying on mutual aid plans and cash to cover rising medical costs.
Canadian teens still rank among the world's best in reading, math and science — but scores are slipping. Here's why
Canada's decline in 2025 mirrors a global downward trend, according to the latest findings from the Organisation for Economic Co-operation and Development.
Emily Austin Keeps Finding Ways to Become One of Sports’ Most Talked-About Personalities
Emily Austin has figured out something most people in sports media spend years trying to learn. People remember her. The sports broadcaster and personality continues to build an audience across sports, entertainment and social media. Most recently, Austin made headlines after discussing a potential FIFA World Cup event appearance in New York. She has also…
Ticket sales start for away match in Ried
Altogether this FridayFriday evening under the lights – on 11 September 2026, our Red Bulls will be away at SV Ried at 19:30! Anyone wanting to support us on this nearby away trip will find all the ...
Healthwatch: Survey reveals how social media influences men’s health
A new Cleveland Clinic survey finds that while a majority of men never trust health information shared by influencers, they are still being influenced.
Molina to make first Roma start in Fenerbahce clash
Nahuel Molina is eagerly awaiting his Roma debut. The Argentine winger, not in top form after playing in the World Cup final, is gradually finding more playing time and is now awaiting a starting spot...
Reds want long-term Hughes replacement
With Richard Hughes' move to Al-Hilal now confirmed, Liverpool are seeking a new sporting director for the fifth time since 2022. Hughes joined Liverpool in the summer of 2024 and oversaw the appointments of Arne Slot then Andoni Iraola. Mike Gordon, the president of Fenway Sports Group (FSG), is overseeing the process of finding Hughes' replacement, with Liverpool keen to make a swift appointment.
Rate My UCL MD1 Fantasy Team
Picking your team for Champions League Matchday 1 is always an exciting and stressful experience. After days of weighing up different options, checking player prices and changing my mind, my squad is finally locked in. Building this squad was all about finding the right balance. Rather than spending most of my budget on a few […]
Millwall vs Newcastle United – Match preview and team news
Millwall host Newcastle United in the Carabao Cup third round on Tuesday, with the Magpies looking to build on an unbeaten start under new head coach Matthias Jaissle against a Championship side findi...
How Energy Justice Is Changing Women’s Lives in Blantyre
By Temwanani Banda, Blantyre, Malawi Every day, before I think about my business, my family or even myself, there is one question that has always come first: How will we cook today? For many women in Blantyre District, Malawi, cooking begins long before a pot is placed on the fire. It begins with finding fuel. […]
No goals but Emery knows Villa's forwards need time
Aston Villa have not scored in their opening three Premier League games - how will manager Unai Emery find their attacking edge?
Tech Tuesday: Can AI help make political polling more accurate?
A group of researchers at Ohio State is working to find out if AI can play a role in helping to make the results of political polls more accurate.
Scientists studying cockroach milk and nose-blowing win Ig Nobel prizes for quirky science
Ten research teams were honored Thursday at a satirical science awards ceremony that was hosted outside the U.S. for the first time due to travel concerns.
Clancy murder case spotlights maternal mental health in U.S., Arkansas
The murder trial of Lindsay Clancy in the January 2023 killing of her three young children ended in a mistrial in Massachusetts on Friday when one of 12 jurors refused to join the others in finding her not guilty by reason of insanity.
Tulane Facing Must-Win Game in Second Matchup of Season
After a disastrous start to the season, the Green Wave needs to find a way to get back on track.
Nearly 1.7 million deaths linked to second-hand smoke in 2023, study finds
More than 2.7 billion people worldwide, including 767 million children, were exposed to second-hand smoke in 2023, contributing to nearly 1.7 million deaths, a Lancet study said on Tuesday. Researchers…
Mental Health Minute: Bonding with your children through social media
Setting screen-time limits with your kids can be a tall task, but parents are finding ways to bond with their teens using social media.
Maresca agrees with Haaland that players started season jaded
Manchester City coach Enzo Maresca said on Monday finding form early in the season "was not easy" for his World Cup players ahead of the club's Champions League opener at Porto."It's it's not easy for them it's not easy for Erling, it's not easy for most of the players that they continue to play for their international team," said the coach.
Arsenal continue to track highly rated Serie A attacker
Arsenal were keen to sign Kenan Yildiz in the last transfer window and made that clear as they tried to find an opening to make their move, but Juventus insisted that he was not on the market.Yildiz i...
Colts share good news on WR Alec Pierce’s ankle injury
The Colts provided the latest update on receiver Alec Pierce recovery from offseason ankle surgery and it’s good news
Small bowel microbiome offers clues to women's health
A new study by investigators at Cedars-Sinai Health Sciences University has identified differences in the makeup and organization of the small bowel microbiome between women and men. The findings, published ...
Follow U-T business reporter in S. Korea as he navigates digital kiosks, gets a style makeover, finds a San Diego connection
Business reporter Phillip Molnar explores ties between South Korea and San Diego.
Harvest Festival 2026: Applin Picking
Pokémon GO’s Harvest Festival runs September 29 to October 5, 2026. Find out about Shiny Applin, Mossy Lures, event bonuses, research, and GO Pass rewards.
Cleveland Clinic survey find social media motivates men’s health habits, but carries risk
Cleveland Clinic says social media can motivate men to improve their health, but doctors warn against self-diagnosis and unregulated supplements.
Leak Hints at Four New Features for Apple Watch Series 12 and Ultra 4
Ahead of the announcement of the Apple Watch Series 12 and Ultra 4 later this week, code in the watchOS 27 and iOS 27 betas points to a series of new features for the product line. The information comes from a new post from MacRumors forums member "pdfu". The findings include: New "Readiness" app: An all-new separate Watch app referred to in code as "Readiness," distinct from the existing Vitals app.
Stanford study finds mental health warning labels on social media may reduce teen use
Czech fire services find safety violation at entertainment venues
Czech fire service officials have found more than 2,300 fire safety violations during inspections of entertainment venues prompted by the inferno at the Swiss resort of Crans-Montana, Interior Ministe...
Arizona Diamondbacks News, 9/7: Houston, we have no problem…
Recaps [AZ Central] Diamondbacks find a way, tip Astros as E. Rodriguez, Arenado shine – The Diamondbacks took the lead in an unconventional fashion in the third. Shortstop Geraldo Perdomo led off with a single but was struck down by a Ketel Marte line drive, which connected with Perdomo’s helmet. Perdomo stayed down for a […]
Should Value Investors Buy Option Care Health (OPCH) Stock?
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
Do black holes have hidden hair? Scientists find a new way to check
When two black holes crash together and merge, the newly formed black hole rings like a bell, sending out gravitational waves with specific frequencies that fade over time. This brief, fading pattern ...