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Entertainment Listing: March 25

Wednesday March 25 Hangar 9 • Carbondale Open deck night, 9 p.m. PK’s • Carbondale Advertisement Trivia, 8 p.m. Project Human X • Carbondale Open studio, 4 p.m. Little Nashville • Marion Bingo, 6 p.m. Thursday March 26 Booby’s • Carbondale Karaoke, 8:30 p.m. Hangar 9 • Carbondale Jim Foerster and Jeff Bradley, 5 p.m....

Mar 26 • 2:45 AM EDT • Entertainment • dailyegyptian.com

Roadmap Writers, Everard Entertainment Set Sonja O’Hara’s ‘Slay’ For Feature Development Following Competition Win; Scott Glassgold Producing

EXCLUSIVE: Sonja O’Hara has emerged as the inaugural grand prize winner of a new writing competition, aimed at discovering commercially viable short stories for feature adaptation, from Roadmap Writer...

Mar 25 • 3:56 PM EDT • Entertainment • nz.news.yahoo.com

Afeela EVs Really Are Vaporware. Sony, Honda Kill Entertainment-Focused Car

Sony's plans depended on technology from three upcoming Honda models. When Honda cancelled those EVs, Sony did 'not have a viable path forward' on Afeela.

Mar 25 • 11:53 AM EDT • Entertainment • pcmag.com

Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com

UMass Chan junior faculty receive child health research grants from Hood Foundation

Silvia Galván Peña, PhD, and Jin Zhang, PhD, are two of five recipients of a 2026 Hood Foundation Award.

Mar 25 • 12:13 AM EDT • Health • umassmed.edu

Cordova students will compete in Alaska Science Olympiad

Students will be traveling from Cordova, Keni, Minto, Nome, Palmer, Seldovia and Utqiagvik to compete with counterparts in the Fairbanks North Star Borough.

Mar 24 • 9:03 PM EDT • Science • thecordovatimes.com

Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com

When to book summer flights for 2026 as oil prices rise

Rising oil prices and travel disruptions are pushing airfares higher. We asked travel and aviation experts for advice on when to book summer flights.

Mar 24 • 12:34 PM EDT • Business • businessinsider.com

2025 extended Session cost Florida taxpayers more than $259K

And there's plenty of extra work to do this year.

Mar 24 • 4:15 AM EDT • Politics • floridapolitics.com

Microsoft Exchange Online service change causes email access issues

Microsoft is working to address an ongoing service issue that has intermittently prevented some users from accessing their cloud-based Exchange Online mailboxes via Outlook mobile and Mac desktop clients since Thursday.

Mar 23 • 8:17 AM EDT • Technology • bleepingcomputer.com

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

PICROSS S KONAMI ANTIQUES edition announced for Switch

Jupiter has announced PICROSS S KONAMI ANTIQUES edition for Switch. It will launch via Nintendo eShop on April 30 for $17.99 / €17.99 / £16.19 / ¥1,800.

Mar 22 • 11:01 AM EDT • Technology • gematsu.com

VoidStealer malware steals Chrome master key via debugger trick

An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.

Mar 22 • 10:32 AM EDT • Technology • bleepingcomputer.com

American football takes for ever. In which other sports do you spend most of your time not playing the game?

The long-running series in which readers answer other readers’ questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts

Mar 22 • 10:00 AM EDT • Sports • theguardian.com

Las Vegas wellness festival shares mental health resources through arts

A yearly festival connected people with mental health resources via the arts in Downtown Las Vegas on Saturday.

Mar 21 • 9:24 PM EDT • Health • news3lv.com

Surprise! Minecraft Dungeons 2 is coming later this year

Surprise! Minecraft Dungeons 2 is coming to PC via Xbox and Steam, PS5, Nintendo Switch and Switch 2, and Xbox Series a…

Mar 21 • 2:22 PM EDT • Technology • eurogamer.net

Top business aviation banker talks debt, profits, JetGate, EBITDAR

Jefferies' Nick Fazioli on why Wall Street loves private jets, non-GAAP financial metrics and why past results don't preclude more investment

Mar 21 • 1:51 PM EDT • Business • privatejetcardcomparisons.com

Doctors are in: Stuffed animals get health checks at zoo's Teddy Bear Care Fair

Toddlers Eliza and Olivia Altman watched attentively as Toledo Zoo & Aquarium volunteers performed “surgery” on their nearly decapitated stuffed animals ...

Mar 21 • 10:26 AM EDT • Health • toledoblade.com

Downtown Chico business owner voices concerns over street closures for events

A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });

Mar 20 • 8:45 PM EDT • Business • actionnewsnow.com

Rivian and the danger of building a business on government largesse

The EV market is evolving to survive without public subsidies.

Mar 20 • 6:19 PM EDT • Business • washingtonpost.com

Samsung confirms Galaxy S26 will get AirDrop support via Quick Share ‘soon’

As expected, Samsung has just confirmed plans to launching AirDrop support via Google’s Quick Share on its Galaxy S26 series...

Mar 20 • 9:35 AM EDT • Technology • 9to5google.com

USA TODAY Sports unveils 2026 ALL-USA Southwest Boys Basketball Team

Reese Alston, Kavian Bryant headline 2025-26 ALL-USA Southwest Boys Basketball Team.

Mar 19 • 3:50 PM EDT • Sports • sports.yahoo.com

NBAA: Business Aviation’s Leadership in Sustainability Innovation Underscored in ‘CLIMBING. FAST.’ Capitol Hill Fly-In

The CLIMBING. FAST. Capitol Hill Fly-In, organized by NBAA, underscored the industry's essential role in supporting 1.3 million American jobs and nearly $340 billion in economic output, while driving innovation in sustainable technologies and clean fuels.

Mar 19 • 9:14 AM EDT • Business • nbaa.org

Amazon brings Alexa+ to the UK

The company is currently letting users in the U.K. try out Alexa+ for free via an early access program.

Mar 19 • 8:27 AM EDT • Technology • techcrunch.com

Uber strikes deal with Rivian to buy thousands of robotaxis

The two companies announced a deal that will see Uber buy 10,000 fully autonomous Rivian robotaxis and invest up to $1.25 billion in the Tesla rival.

Mar 19 • 8:25 AM EDT • Business • businessinsider.com

This Week in Sports Trivia: March 19, 2026

How closely were you following the sports news this week? Find out and test your knowledge by taking The Athletic's weekly quiz.

Mar 19 • 7:00 AM EDT • Sports • nytimes.com

TSA officers are the latest aviation workers to be used as ‘political pawns.’ Now, they just want the shutdown to end

For over a month, Transportation Security Administration employees have been showing up to work at US airports without getting paid.

Mar 19 • 4:45 AM EDT • Politics • cnn.com

Vonovia Swings to Net Profit on Rental Business Strength

The real-estate company posted a net profit of €3.72 billion in 2025 compared with a net loss of €896 million in the prior year.

Mar 19 • 2:47 AM EDT • Business • wsj.com

Oil prices hold steady even as Iraq resumes some exports via Turkey

Oil prices held steady Wednesday after Iraq clinched a deal to resume some crude exports via Turkey. It’s not a ton of oil, but it’s what amounts for good news these days as the Strait of Hormuz remains largely blocked.

Mar 18 • 6:56 AM EDT • Business • cnn.com

Oil price falls after Iraq ‘signs deal’ to resume exports via Turkey

Rolling coverage of the latest economic and financial news

Mar 18 • 3:39 AM EDT • Business • theguardian.com

I Flew JetBlue Business Class to London and Came Home a Fan

Our columnist traveled via Mint service on the underdog airline from JFK to Heathrow.

Mar 17 • 9:00 PM EDT • Business • wsj.com

The 2026 Lollapalooza lineup just dropped: Everything to know about dates, headliners, tickets and more

The annual four-day music festival officially returns to Grant Park in Chicago, Illinois July 30-Aug. 2 with over 150 musicians including this year's headliners Charli XCX, Tate McRae, Lorde, Olivia Dean, John Summit, Jennie, The Smashing Pumpkins and The xx.

Mar 17 • 12:32 PM EDT • Entertainment • al.com

Samsung to Discontinue Galaxy Z TriFold After Just Three Months

Samsung is set to discontinue the Galaxy Z TriFold globally after just three months on sale (via Bloomberg). The company will start by ceasing sales of the device in Korea, where it has been on sale since December. Samsung plans to discontinue the device in the United States once it clears its inventory. Samsung's website already lists the TriFold as "sold out," but customers are still able to buy the device at Samsung stores.

Mar 17 • 9:11 AM EDT • Technology • macrumors.com

Wagoner Community Hospital delays March 13 paychecks, cites soft business deposits

Employees at Wagoner Community Hospital were expecting their March 13th paycheck but instead were notified via email their payroll would be delayed.News Channel

Mar 16 • 10:27 PM EDT • Business • ktul.com

Merlin and Inflection Point Acquisition Corp. IV Announce Closing of Business Combination

Merlin's Cessna Caravan Merlin's aircraft flying overhead at the company's Quonset, RI hangar Merlin's Quonset, RI Hangar A C-130J flying overhead at Merlin’s Quonset, RI hangar Transaction provides more than $200M in gross proceeds to accelerate commercialization of AI-powered autonomous aviation Merlin to Begin Trading on March 17th on the NASDAQ Under Ticker Symbol “MRLN” BOSTON, March 16, 2026 (GLOBE NEWSWIRE) -- Merlin, Inc., an aerospace and defense technology company building the operatin

Mar 16 • 4:01 PM EDT • Business • finance.yahoo.com

Samsung allegedly launches Galaxy A37 and A57; pricing is turning heads

It turns out that Samsung has silently unveiled the Galaxy A37 and A57 in Thailand, with the pricing is the first thing that makes you stop scrolling. The Galaxy A57 5G and Galaxy A37 5G are now official in Thailand, via droidsans. The two phones look like typical yearly upgrades to the A series. In reality, […]

Mar 16 • 3:05 PM EDT • Technology • sammyfans.com

Sony Confirms PlayStation 5 Pro PSSR Upgrades for Cyberpunk 2077, Final Fantasy 7 Rebirth and Even Former Xbox Console Exclusive Hellblade 2

Sony has confirmed an array of games set to benefit from PlayStation 5 Pro's upgraded PSSR visual boost, which launches more broadly via a new system software update available later today.

Mar 16 • 12:01 PM EDT • Technology • ign.com

Farage Mega Donor Exposes Vulnerability in UK Politics

Britain’s biggest political donor is a crypto investor and aviation entrepreneur who has lived in Thailand for more than two decades. The £12 million ($16 million) that Christopher Harborne gave to Nigel Farage’s Reform UK last year wouldn’t be permitted in France, Canada or Ireland. If you’re sensing something askew with the UK’s rules for campaign finance contributions, you’re not alone.

Mar 16 • 1:00 AM EDT • Politics • bloomberg.com

Galaxy A37 and A57 unboxing and hands-on leak ahead of launch

Samsung hasn’t unveiled the Galaxy A37 and Galaxy A57 yet, but someone has already unboxed the phone and had hands-on experience. Galaxy A37 and A57 unboxing and hands-on videos leak on TikTok (via @VerdeSelvans/X). The clips expose the design of both phones and first look at the software. The retail box features the model name […]

Mar 15 • 11:47 PM EDT • Technology • sammyfans.com

Africa’s Business Aviation Rebirth

Africa's business aviation sector has lived under the weight of a stubborn global stereotype: a continent defined by ageing aircraft, fragmented regulation and limited economic prosperity.

Mar 15 • 8:00 PM EDT • Business • aviationweek.com

Airline CEOs torch lawmakers for turning air travel into a ‘political football’

Airline leaders warned the DHS shutdown left TSA workers unpaid and travelers facing long lines as spring travel demand surged and pressure mounted on the aviation system.

Mar 15 • 9:29 AM EDT • Politics • foxnews.com

Scientists Unveil Cheaper and Faster Way To Extract Lithium From Massive Untouched Reserves

A new solvent-based technique could change how lithium is extracted from brines, potentially making the process faster, cheaper, and viable in places where conventional methods fail. Few elements are as key to the clean energy transition as lithium, and global demand for it is soaring. The metal

Mar 15 • 1:49 AM EDT • Science • scitechdaily.com

White House war promo videos marry action movies, sports and video games to real-life combat footage

Some critics, including an official with the U.S. Catholic Church, have accused the administration of trivializing a real-life conflict.

Mar 14 • 6:31 PM EDT • Sports • wlwt.com

Viagra may treat deadly disease in children

Mar 14 • 10:45 AM EDT • Health • nypost.com

Spirit Airlines to shrink fleet to one‑third of pre‑bankruptcy size

Spirit Aviation Holdings , the parent company of Spirit ​Airlines, said on Friday it plans to shrink its fleet to about one‑third of its pre‑bankruptcy size, according ‌to a court filing.

Mar 13 • 7:21 PM EDT • Business • reuters.com

Centennial Students Earn 3rd Place at Iowa Regional Science Bowl

Michael Stevens, Ian Anderson, Anna Bruns, Jared Bond, Alice Baghdasaryan and teacher Madison Greif. (Not pictured: Team Manager Vivian Zhang.) Congratulations to our outstanding team for earning 3rd place at the 2026 Iowa Regional High School Science Bowl, held on the campus of Iowa State University on March 7! We’re proud of these students for representing our school with excellence in this challenging academic competition that tests knowledge in science, mathematics, and teamwork.

Mar 13 • 3:56 PM EDT • Science • ankenyschools.org

Samsung lists apps that work directly via satellite on Galaxy phones

Samsung has started listing apps that work directly via a satellite connection on compatible Galaxy phones in select countries and markets.

Mar 13 • 7:59 AM EDT • Technology • sammobile.com

Vaxart Provides Business Update and Reports Full Year 2025 Financial Results

Topline data from 400-person sentinel cohort of the Phase 2b COVID-19 trial anticipated early Q2 2026 Published positive clinical results in the first quarter of 2026 demonstrating oral norovirus vaccine candidate was safe and immunogenic in lactating women and resulted in passive transfer of antibodies to their infants via breast milk Cash, cash equivalents and investments of $63.8 million as of December 31, 2025; Runway into second quarter of 2027 Conference call today at 4:30 p.m. ET Live sto

Mar 12 • 4:05 PM EDT • Business • finance.yahoo.com

Dassault reveals Falcon 10X with largest cabin in business aviation

Dassault Aviation has unveiled the Falcon 10X ultra-long-range business jet with spacious cabin and a 7,500-nautical-mile range.

Mar 12 • 7:43 AM EDT • Business • aerospaceglobalnews.com

This Week in Sports Trivia: March 12, 2026

NFL free agency is always a whirlwind, and this year’s feeding frenzy has been as busy as ever. The legal tampering period — we have a great explainer on that here — ended Wednesday, with a host of deals finally becoming official. Moves included Daniel Jones re-upping with the Indianapolis Colts, Jaelan Phillips signing with the Carolina Panthers and Mike Evans ending a long run with the Tampa Bay Buccaneers in favor of a deal with the San Francisco 49ers. The biggest news of the week, though, was a trade that went down — until it didn’t. That, of course, was the Las Vegas...

Mar 12 • 7:00 AM EDT • Sports • nytimes.com

Valve Issues Scathing Public Response to New York Attorney General's Loot Box Lawsuit

The New York state attorney general, Letitia James, recently announced that she was taking Valve to court over what she called "quintessential gambling" via loot boxes in games like Counter-Strike, Team Fortress, and Dota, stating that these loot boxes target children and adolescents, and that they ...

Mar 11 • 5:58 PM EDT • Technology • techpowerup.com

WordPress debuts a private workspace that runs in your browser via a new service, my.WordPress.net

WordPress’s new browser-based service lets users create private sites without hosting or signup, turning the platform into a personal workspace for writing, research, and AI tools.

Mar 11 • 12:43 PM EDT • Technology • techcrunch.com

WhatsApp launches preteen accounts, here’s how they work

WhatsApp has announced that preteens can now use its messaging platform via new parent-managed accounts that come with certain restrictions.

Mar 11 • 12:36 PM EDT • Technology • 9to5mac.com

Why Attend - 2026 NBAA White Plains Regional Forum

Join us for the top business aviation event in the Northeast! This one-day program is jam-packed with networking opportunities, an aircraft display, educational sessions and a hangar filled with a wide variety of exhibits. Connect with industry professionals, stay informed on the latest topics in business aviation and discover an amazing array of products and services.

Mar 11 • 6:12 AM EDT • Business • nbaa.org

Primary Care Is in Trouble. So Doctors Band Together To Boost Their Market Power.

Thousands of primary care practices are fighting to remain financially viable and independent. Many are banding together to form Independent Physician Associations, or IPAs, to increase their market power.

Mar 11 • 5:00 AM EDT • Health • kffhealthnews.org

Dassault Aviation unveils long-range Falcon 10X business jet

Dassault Aviation rolled ​out its latest long-range ‌business jet, the Falcon 10X, on ​Tuesday, marking a ​key public milestone as the ⁠French planemaker challenges ​larger North American ​rivals at the top end of the luxury aircraft ​market.

Mar 10 • 3:04 PM EDT • Business • reuters.com

Asus releases new 14-inch gaming laptop in the US with AMD Strix Halo

Asus has finally started selling its first AMD Strix Halo gaming laptop in the US. Equipped with a 165 Hz display, the new laptop also features a 73 Wh battery with 100 W charging via USB Type-C. Unfortunately, Asus has decided against offering a 64 GB RAM variant in the US, which would have allowed the TUF Gaming A14 FA401EA to assign up to 48 GB VRAM to its Radeon 8060S iGPU.

Mar 10 • 2:35 PM EDT • Technology • notebookcheck.net

Windows 11 KB5079473 released with features, direct download links for offline installers (.msu)

Windows 11 KB5079473 is now rolling out as part of Microsoft’s March 2026 Patch Tuesday, and it has up to nine new features, including Emoji 16, Internet Speed Test, Extract all options in Explorer, and more. You can download it via Windows Update or use one of the direct download links for KB5079473 offline installers […]

Mar 10 • 1:00 PM EDT • Technology • windowslatest.com

Pixel 11 Pro Fold Already Looking Pretty Hot

This week we’re getting our first possible look at the Pixel 11 Pro Fold, a followup to last year’s Pixel 10 Pro Fold. The look is via CAD renders published by @Onleaks and... #Android #Google

Mar 9 • 5:06 PM EDT • Technology • droid-life.com

Samsung promises 120 games will be playable via its glasses-free 3D monitor tech by the end of the year

Samsung just announced that 120 games will be playable via its Odyssey 3D Hub platform by the end of the year. This is the platform that allows for glasses-free 3D gaming on Odyssey monitors.

Mar 9 • 2:01 PM EDT • Technology • engadget.com

G-MODE Archives+ Digital Devil Saga: Avatar Tuner: A’s TEST Server announced for Switch, PC

G-MODE will release ATLUS-developed game Digital Devil Saga: Avatar Tuner: A’s TEST Server as a G-MODE Archives+ title for Switch via Nintendo eShop and PC via Steam in Japan, the company ann…

Mar 8 • 11:15 PM EDT • Technology • gematsu.com

SHINONOME ABYSS: The Maiden Exorcist launches March 26

Roguelike horror action game SHINONOME ABYSS: The Maiden Exorcist will launch for Switch and PC via Steam on March 26, publishers Kadokawa Corporation, Kadokawa Game Linkage, and ABC ANIMATION, and…

Mar 8 • 9:35 PM EDT • Technology • gematsu.com

Particles may not follow Einstein’s paths after all

Physicists have long struggled to unite quantum mechanics—the theory governing tiny particles—with Einstein’s theory of gravity, which explains the behavior of stars, planets, and the structure of the universe. Researchers at TU Wien have now taken a new step toward that goal by rethinking one of relativity’s core ideas: the paths particles follow through curved spacetime, known as geodesics. By creating a quantum version of these paths—called the q-desic equation—the team showed that particles moving through a “quantum” spacetime may deviate slightly from the paths predicted by classical relativity.

Mar 8 • 8:00 PM EDT • Science • sciencedaily.com

AI Can Cut Months Off Your Business Launch and Boost Your Profits Faster

AI is dramatically shortening the time it takes to launch and monetize an online business. Here's how entrepreneurs are using AI to move faster without sacrificing long-term viability.

Mar 8 • 11:00 AM EDT • Business • entrepreneur.com

2028 NBAA Business Aviation Convention & Exhibition (NBAA-BACE)

New Orleans Awaits The world’s premier business aviation event, NBAA Business Aviation Convention & Exhibition (NBAA-BACE), is landing in New Orleans,

Mar 6 • 2:30 PM EST • Business • nbaa.org

Grading Apple's release week - MacBook Pro, Air, Neo, and more!

Apple's week of launches has seen it update its iPhones, MacBooks, iPads, and displays, but only some updates are stand-outs while the rest are trivial.

Mar 5 • 7:37 AM EST • Technology • appleinsider.com

This Week in Sports Trivia: March 5, 2026

How closely were you following the sports news this week? Find out and test your knowledge by taking The Athletic's weekly quiz.

Mar 5 • 7:00 AM EST • Sports • nytimes.com

Pasqal, A Global Leader in Neutral Atom Quantum Computing, to Go Public via Business Combination with Bleichroeder Acquisition Corp II

Pasqal Holding SAS (“Pasqal”), a global leader in neutral atom quantum computing, and Bleichroeder Acquisition Corp. II (“Bleichroeder”), a SPAC led and back...

Mar 4 • 4:05 PM EST • Business • businesswire.com

Wake County to host measles edition of Ask the Doc Town Hall

Wake County Public Health will hold a special measles-focused Ask the Doc Town Hall on March 10 at 6 p.m., offering residents a chance to learn about symptoms, risks, prevention, and vaccination from local medical experts via Zoom or Facebook Live.

Mar 3 • 7:00 PM EST • Health • wake.gov

What your Meta smart glasses record doesn’t stay on your smart glasses, ‘data labeling’ contractors say

Meta contractors say they’ve been tasked with reviewing highly sensitive videos captured by the company’s smart glasses.

Mar 3 • 5:28 PM EST • Technology • san.com

Ilitch Sports + Entertainment Announces Launch of Detroit SportsNet

Ilitch Sports + Entertainment announces the launch of Detroit SportsNet (DSN), a year-round broadcast home for two of Detroit's franchises. With flexible options to watch via cable/satellite television packages and...

Mar 3 • 5:30 AM EST • Entertainment • sportsvideo.org

Colorado legislature should not reverse lottery modernization

By Bill Clayton Four years ago, the Colorado General Assembly passed bipartisan legislation to modernize the state’s lottery system and strengthen funding for Colorado’s outdoor projects and open spaces. Lawmakers recognized a simple reality: consumer behavior has evolved. Most Coloradans no longer rely on cash for everyday transactions. If the lottery was to remain viable […]

Mar 3 • 2:45 AM EST • Politics • coloradopolitics.com

Prolonged Mideast crisis could shut oil output itself

If export routes via the Strait of Hormuz remain blocked, producers could be forced to halt production as storage fills up.

Mar 3 • 2:16 AM EST • Business • businessinsider.com

What’s Up: March 2026 Skywatching Tips from NASA

What are some skywatching highlights in March 2026? A total lunar eclipse blood moon takes centre stage, Venus and Saturn cozy up for a conjunction, and we celebrate the vernal equinox.

Mar 2 • 3:45 PM EST • Science • science.nasa.gov

New Chrome Vulnerability Let Malicious Extensions Escalate Privileges via Gemini Panel

Chrome CVE-2026-0628 let malicious extensions hijack Gemini panel for privilege escalation, local file access, and surveillance.

Mar 2 • 12:08 PM EST • Technology • thehackernews.com

Ilitch Sports + Entertainment announces launch of Detroit SportsNet

Ilitch Sports + Entertainment today announced the launch of Detroit SportsNet (DSN), a year-round broadcast home for two of the most iconic franchises in sports. With flexible options to watch via cable/satellite television packages and in-market streaming, Detroit SportsNet is the place to watch all locally televised Detroit Tigers (starting

Mar 2 • 12:01 PM EST • Entertainment • mlb.com

Ilitch Sports + Entertainment announces launch of Detroit SportsNet

Ilitch Sports + Entertainment today announced the launch of Detroit SportsNet (DSN), a year-round broadcast home for two of the most iconic franchises in sports. With flexible options to watch via cable/satellite television packages and in-market streaming, Detroit SportsNet is the place to watch all locally televised Detroit Tigers (starting

Mar 2 • 12:01 PM EST • Sports • mlb.com

Germany Sixteen Tons Entertainment Hire

In this image released on Monday, March 2, 2026, Sebastian Nussbaum, new Chief Creative Officer at Sixteen Tons Entertainment. (Sixteen Tons Entertainment/news aktuell via AP Content Services)

Mar 2 • 11:07 AM EST • Entertainment • gazettextra.com

Matches To Make After UFC Mexico City

UFC Mexico City went down last night (Sat., Feb. 28, 2026) inside Arena CDMX in Mexico City, Mexico, which saw Lone’er Kavanagh defeat Brandon Moreno via unanimous decision in a pivotal men’s Flyweight bout. In the co-main event of the evening, David Martinez secured his tenth straight win, defeating Marlon Vera via unanimous decision, while […]

Mar 1 • 8:00 PM EST • Sports • sports.yahoo.com

Lenovo Unveils an Attachable AI Agent 'Companion' for Their Laptops

As the Mobile World Conference begins in Spain, Lenovo brought a new attachable accessory for their laptops — an AI agent. CNET reports: The little circular module perches on the top of your Lenovo laptop display, attached via the magnetic Magic Bay on the rear. The module is home to an adora...

Mar 1 • 7:00 PM EST • Technology • mobile.slashdot.org

Global webinar on core public health capacities to conduct ship inspections and issue ship sanitation certificates

Ships cross borders every day, connecting countries and serving as a backbone of the global economy. However, outbreaks onboard can disrupt maritime traffic, leading to significant economic and operational negative consequences. Without strong public health capacities to detect, prevent, and respond to public health risks on board ships, maritime travel can also become a pathway for the spread of infectious diseases. To support countries in strengthening these capacities, the World Health Organization (WHO) convened a two-day webinar on 11–12 February, bringing together more than 700 ship inspectors, port health officers, and public health authorities, primarily from the African, Eastern Mediterranean, and European Regions. The webinar came at a pivotal time. With the amended International Health Regulations entering into force on 19 September 2025, the need to focus on public health preparedness has never been greater. Strengthening public health capacities at borders, including onboard conveyances, is a cornerstone of global health security and central to the amended IHR.“The high level of attendance and active participation throughout the two days of the webinar highlighted the growing demand for technical guidance and capacity-building support in ship inspection and issuance of ship sanitation certificates”, said Dr Ninglan Wang, Head of the Borders, Mass Gatherings and Health Protection Measures (BMM) Unit at the Health Emergency Preparedness Department at WHO headquarters. “The dynamic interactions among experts and countries underscored the value of continued cross-border collaboration in the maritime sector and knowledge exchange in this area”. Conducting regular public health inspections on board ships for the issuance of ship sanitation certificates (SSCs) in accordance with the IHR requirements is crucial for ensuring that ships meet specific health standards, thereby minimizing the risk of the international spread of diseases via maritime traffic. These certificates, mandated by the IHR, require ports to have trained personnel who can identify and control public health risks on board vessels and apply recommended control measures. This standardized global procedure not only ensures compliance with the IHR but also promotes consistency in health practices across ports worldwide. SSCs are the globally-recognized tool used to prevent and control known public health risks on ships, providing a common way to register and communicate public health events and measures taken on board between all stakeholders involved in this process, including public health authorities in ports and ship operators. Only SSCs issued by ports authorized by national authorities to issue such certificates are considered valid. As per the IHR, all States Parties are required to send to WHO their list of authorized ports (available here) and to keep it updated. However, many Member States continue to face practical challenges, such as limited resources, high staff turnover, and competing priorities. These realities underscore the value of platforms such as this webinar, which foster collective learning, peer-to-peer exchange, and practical solutions to help countries build and sustain the capacities required under the IHR.Over the two days, participants engaged in presentations and discussions covering a wide range of technical and operational topics, such as the overarching international legal framework governing ship sanitation; considerations for pre-inspection planning; risk assessment factors by type of vessel; the completion and issuance of SSCs and evidence report forms; or practical insights on the inspection of various technical areas, such as food safety, medical facilities, water systems, or vector control, among others. In addition, public health authorities from the Netherlands, Morocco, and Tanzania shared case studies to showcase their practical application of these IHR requirements in their respective countries. Given its success, WHO plans to replicate similar sessions in the future to reach additional time zones and regions and cover other pressing border health-related topics, ensuring that Member States can continue benefiting from these opportunities to share knowledge and expertise.

Mar 1 • 7:00 PM EST • Health • who.int

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