SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " rui " 2,093 found 🔀 AI-powered Shuffle
Fresh Food Distributors Add Surcharges as Fuel Costs Rise
Delivering salmon, fruits and other perishable foods has become more expensive as the war with Iran pushes up diesel prices.
Women's NCAA Tournament: UConn, UCLA, Texas and South Carolina make Final Four
The Huskies will play the Gamecocks and the Bruins will take on the Longhorns this Friday in Phoenix.
Oil rises for a fourth day on supply cuts from widening Middle East conflict
Oil prices rose for a fourth day on Tuesday, with Brent crude poised for its largest monthly gain on record and U.S. crude futures set for their strongest monthly increase since 2020, because of supply constraints from the widening Middle East war.
Three-star IOL Jackson Cook commits to Texas
Texas landed its first offensive linemen of the 2027 recruiting cycle and they stayed local to do so. In recent cycles, Texas has landed several players from local Austin powerhouse program Austin Westlake. Guys like Michael Taaffe, Ethan Burke, Conner Robertson, and Colton Vasek all decided to stay home play for the Longhorns and now […]
Bruins to Host Women in Sports Night, Presented by Rapid7, on March 31
The Boston Bruins will host Women in Sports Night, presented by Rapid7, on Tuesday, March 31, during their home game against the Dallas Stars at 7 p.m. at TD Garden. This year, hosted during Women's History Month, the Bruins' Women in Sports Night aims to recognize individuals and organizations from
Big Tech sports broadcast rights could imperil US local TV news, stations say
Major broadcast station owners on Monday said U.S. regulators should address the trend of Big Tech companies acquiring the rights to broadcast football, baseball and other sporting events, saying it could weaken local TV news.
How systems science helps keep my flower delivery costs low
When you go out to run errands on the weekend, you're on a "tour" as defined by human mobility researchers. Same if you book a guided tour of a famous city or take a trip on a cruise boat that reaches ...
[*LIVE*] Tennessee vs Michigan Live Free Streams On Sport'sTvｌ 30 March 2026
Tennessee vs Michigan in a highly anticipated clash of the 2026.These rule changes are seen as part of Live NCAAM ( Men's Collage BasketBall) ongoing efforts to evolve the game and maintain competitive integrity across formats.Pluto TV and All Men's Sports Network Forge Global Partnership to Launch a New FAST Channel and Media.
Sport NI CEO leaves role after two-year absence
Antoinette McKeown has left the post of Sport NI chief executive after a two-year absence from the role. Chair Gavin Boyd confirmed to employees in a message seen by BBC Sport NI that Ms McKeown had left the post on 24 November 2025 to "take up new opportunities" and the recruitment process to replace her was "progressing". Sport NI, the leading public body for the development of sport in Northern Ireland, has come in for criticism in recent years.
Buy this cruise line operator that's trading at a discount, says HSBC
The bank upgraded the cruise operator to buy from hold.
The list of people hit by recent Epic layoffs has been turned into a dedicated portal for recruiters
Google sheet turned into dedicated website, while Tim Sweeney steps in following outcry over laid-off worker losing cancer treatment
Why GM thinks OnStar, Super Cruise subscriptions will soon ‘fundamentally transform’ its business
GM sees an "exponential opportunity" to grow its high-margin subscription business, CFO Paul Jacobson said, pointing to strong year-over-year revenue growth.
Jefferson's Bourbon takes ocean ageing to cruise ships
Pernod Ricard-owned Jefferson's Bourbon has partnered with Holland America Line to age its whiskey on the high seas.
Lauren Betts and UCLA return to Final Four with unfinished business
The Bruins' elite status cannot be minimized, and neither can Betts' legacy, but UCLA says its work isn't done.
How Gender Stereotypes Got Written Into Evolution
Feminist biologists have been challenging a flawed fruit-fly experiment that helped harden Victorian stereotypes about sex.
UCLA storms back to beat Duke and reach women's Final Four
The Blue Devils took a 39-31 lead into the half, only the second time that the Bruins trailed at that point this season.
Report: Liverpool considering move to sign Serie A forward
Liverpool Transfer Latest: Francisco Conceição Emerges as Salah Contingency OptionLiverpool’s recruitment drive ahead of a crucial summer window continues to gather pace, with fresh developments p...
World’s tallest bridge and biggest museum named ‘greatest places of 2026’
A heap of shiny new parks, museums, cruises, hotels and attractions have made it into TIME magazine’s 100 “greatest places of 2026,” providing a great excuse to freshen up your
[*LIVE*] Purdue vs Arizona Live Free Streams On Sport'sTvｌ 29 March 2026
Purdue vs Arizona in a highly anticipated clash of the 2026.These rule changes are seen as part of Live NCAAM Men's Collage BasketBall ongoing efforts to evolve the game and maintain competitive integrity across formats.Pluto TV and All Men's Sports Network Forge Global Partnership to Launch a New FAST Channel and Media.
[*LIVE*] Iowa vs Illinois Live Free Streams On Sport'sTvｌ 29 March 2026
Iowa vs Illinois in a highly anticipated clash of the 2026.These rule changes are seen as part of Live NCAAM Men's Collage BasketBall ongoing efforts to evolve the game and maintain competitive integrity across formats.Pluto TV and All Men's Sports Network Forge Global Partnership to Launch a New FAST Channel and Media.
Business briefs: New businesses coming to NKY - Marshalls, Fruit Land, Penn Station
Staff report Marshalls to open in Cold Spring Pointe Marshalls, one of the nation’s leading off-price retailers with over 1,200 stores currently operating in 48 states, D.C., and Puerto Rico, will open at Cold Spring Pointe on April 9. Shoppers in Cold Spring will find an amazing selection of high-quality merchandise across fashion, accessories, shoes,...
USC flips 4-star in latest recruiting win over Oregon
USC football just delivered another recruiting dig at Big Ten rival Oregon, this time landing a four-star tackle.
Florida high School football recruiting rankings: Top 2027 prospects
As the spring sessions kick off, here is a look at the top class of 2027 recruits ahead of the Florida high school football season.
Florida football hosting key recruits this weekend for spring visits
Florida football hosts top recruits for a key March visit weekend that could have major effects on the Gators' first class under Jon Sumrall.
New York Jets Flight Connections 03/28/26
Happy Saturday, Jets fans! Below are your links to kick off this weekend as we keep cruising toward the 2026 NFL Draft. NY Jets – Where Have the Jets Improved their Roster Most this Offseason? Jack Bell – Jets QB Geno Smith: Aaron Glenn is a ‘Special Coach’ Jack Bell – At No. 2 Overall […]
Sarah Strong has a double-double, UConn cruises to Elite Eight, beating UNC
Sarah Strong had 21 points and 10 rebounds as defending national champion and overall No. 1 seed UConn overwhelmed North Carolina 63-42 in the women's NCAA Tournament.
LIVE: Palmetto Sports at Atlanta Braves Opening Day
LIVE: On Atlanta Braves Opening Day, Palmetto Sports Anchor Caroline Soro & Reporter Ella Grogan preview game one from Truist Park.
UCLA's Cori Close says Bruins' success has taken a toll on her
UCLA coach Cori Close is calling for reforms that allow players to be paid and transfer while also supporting worn out coaching staffs.
Maryland Small Business Will Appeal After District Court Affirms Department of Labor Courts That Hand Down Ruinous Fines
WASHINGTON—The Institute for Justice (IJ) will appeal on behalf of C.S. Lawn & Landscaping, a Maryland small business owned by Chuck Saine, after a federal […]
Where to watch UCLA vs. Minnesota in March Madness Sweet 16: Time, TV Channel
The No. 1 UCLA Bruins face the No. 4 Minnesota Golden Gophers in the Sweet 16 of the women's NCAA Tournament. Here's how to see all the action.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Cottage Health Appoints Melissa Ruiz, MD, MPH, as Endowed Chair of Pediatric Residency Program
Credit: Courtesy SANTA BARBARA, CA—March 25, 2026—Cottage Health has appointed Melissa Ruiz, MD, MPH, as the Endowed Chair of the Pediatric Residency
Four-star cornerback Danny Lang commits to USC
After a somewhat slow start, the Trojans’ 2027 recruiting class is quickly heating up
The Riverside-St. Martin's baseball winner was led by a senior pitcher's complete game
Riverside senior right-handed pitcher Jayce Ruiz repeated his prior success against St. Martin’s by throwing a complete game in the second game of a district series.
Meta layoffs hit Reality Labs, recruiting divisions
Meta's latest wave of job cuts follow years of the company pushing to become more efficient and going all in on AI.
BigXthaPlug's Texas Rap Supergroup: Meet 600 Entertainment
BigXthaPlug recruited some of Texas' best rappers, like Rosama, Yung Hood, MurdaGang PB, KaineMusic, and KevanGotBandz, for his 600 Entertainment crew
DJ Lagway leaves Florida drama behind him, rewriting his story at Baylor
DJ Lagway was No. 1 QB in his recruiting class. But self-induced isolation and a run of injuries derailed Florida career. Baylor is a fresh start.
I-490 bridge construction project to resume, Bushnell’s Basin business owners concerned
PERINTON, N.Y. (WROC) – Phase two of the major bridge replacement project along 490 near exit 27 is slated to begin soon, and many businesses in Bushnell’s Basin are preparing. The team at the Fruit a...
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Rural health care providers can now apply for $50M to stabilize access - New round of health care funding builds on record $146M investment - Office of the Governor
SANTA FE – New Mexico’s rural health care providers can now apply for a share of $50 million in health care funding as part of the State of New Mexico’s three-year, $146 million investment that has helped recruit more than 800 health care workers to underserved communities. The funding comes from New Mexico’s Rural Health […]
ASU lands former Saint Mary's recruit JRob Croy
Arizona State basketball earned a commitment from JRob Croy, who was set to join Randy Bennett's 2026 recruiting class at Saint Mary's.
Knoxville sports coach indicted on sexual battery charges
A Knoxville man who coached youth sports teams has been indicted on multiple charges including aggravated sexual battery, the Knoxville Police Department said Tuesday.
How Maryland’s Megan Kelly Walter became a champion in two NCAA sports
Megan Walter was recruited as a two-sport athlete in field hockey and lacrosse coming out of Holton-Arms School in nearby Bethesda.
We’ve Been Underestimating Flying Foxes
Australia used to incinerate the large fruit bats, but research suggests they bring hundreds of millions of dollars in benefits to the country’s economy.
We’ve Been Underestimating Flying Foxes
Australia used to incinerate the large fruit bats, but research suggests they bring hundreds of millions of dollars in benefits to the country’s economy.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Standout safety reclassifies to 2027, recruitment picking up
One of the top safeties in the 2028 class has opted to reclassify to the 2027 class with his recruitment picking up steam.
UCLA tries to enjoy rare opportunity for Lauren and Sienna Betts
UCLA works to celebrate Lauren and Sienna Betts as successful sisters and individual playmakers pushing to help the Bruins win.
UTA College of Business to connect students, professionals with networking, elevator pitch event
Students, business professionals and recruiters will mingle from 6 to 8 p.m. Monday at the UTA Center for Entrepreneurship and Technology Development.
B.C. recruits 400 healthcare workers, most from Washington and Oregon
A successful targeted campaign recruited more than 400 U.S.-trained healthcare professionals to British Columbia, many of whom are from Oregon and Washington.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Winner and Loser of the Week in Florida politics
DeSantis signed a bill seeking to block a Manatee cruise port, while another Republican group is in hot water.
What time is Michigan women's basketball's second round game?
Michigan cruised to a blowout victory over Holy Cross in their opening NCAA Women's Tournament matchup. See who they play next.
Four-star forward Joe Philon commits to UCLA
Joe Philon, a four-star power forward in the 2026 class, has committed to UCLA, he told On3. The 6-foot-8 senior out of Montverde Academy (FL) chose the Bruins after considering Ohio State, South Florida, UNLV, and Xavier. Philon, a native of Tampa, Florida, is the No. 56 overall player in the 2026 class, according to […]
Scientists Recruit Undergrad to Step Into Room Filled With Ravenous Mosquitoes for “Full-Body Massacre”
Researchers at Georgia Tech used undergraduate student Chris Zuo as bait in trials to study mosquito flight behaviors.
Lauren Betts powers UCLA women's basketball in March Madness. What to know about her
Lauren Betts powered UCLA to a 31-1 record entering March Madness, and is looking to help return the Bruins to the Final Four. What to know about her.
Nebraska lands the commitment of 3-star athlete Kaden Howard
The feel-good momentum surrounding the Nebraska athletic department continues to build following the men’s basketball team’s first-round NCAA Tournament victory—and it’s now carrying over onto the recruiting trail. The Cornhuskers have secured a commitment from 3-star athlete Kaden Howard, a 5-foot-10, 160-pound playmaker out of Miami, Florida. Howard picked Nebraska over Louisville, West Virginia and […]
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Super early 2027 Oscars predictions: Will Amy Adams finally win her first Academy Award?
Early 2027 Oscars contenders are already in the running for top awards. Here are EW's super early predictions for nominees, from Tom Cruise and Amy Adams to 'The Odyssey' and 'Dune: Part 3.'
Virginia Tech adds commitment from EDGE Alexander Taylor
Baltimore (Md.) St. Frances Academy edge rusher Alexander Taylor committed to Virginia Tech on Thursday. The three-star prospect announced the decision on X. Taylor is the second commit in the Hokies’ 2027 recruiting class, joining three-star edge rusher Andrew Rogers.
Bruin Capital CEO on sports investing, media rights deals and business of college athletics
George Pyne, Bruin Capital CEO, joins 'Squawk Box' to discuss the state of sports investing, sports media rights negotiations, business of college athletics, what to expect from this year's Bruin Capital conference, and more.
Bruin Capital CEO on sports investing, media rights deals and business of college athletics
George Pyne, Bruin Capital CEO, joins 'Squawk Box' to discuss the state of sports investing, sports media rights negotiations, business of college athletics, what to expect from this year's Bruin Capital conference, and more.
Caitlin Clark named MVP of World Cup qualifying tournament
Indiana Fever point guard Caitlin Clark helped Team USA cruise to a 5-0 record at the tournament. Clark averaged 11.6 points and 6.4 assists.
9 Fruits To Reduce Inflammation In The Body
Fruits are one of the best sources of anti-inflammatory nutrients, helping to reduce chronic inflammation, which has been linked to heart disease, cancer and cognitive decline.
Manatt Recruits Nixon Peabody Entertainment Group Chief Heisler
Entertainment lawyers Ellie Heisler, Jessica Boardman, and Mike Lawhead joined Manatt, Phelps & Phillips as partners in Los Angeles, the firm announced Tuesday.
Chelsea vs PSG – Match preview and team news
Chelsea welcome Paris Saint-Germain to Stamford Bridge tonight, needing a miracle to overturn a daunting three-goal deficit against the Champions League holders.The Blues arrive following a bruising 5...
Nvidia's Jensen Huang pitches tokens as recruitment strategy
Jensen Huang said engineers will soon be asking "how many tokens comes along with my job?" and is willing to pay them tokens worth half their salary.
MSC Group acquires studio in Edinburgh for entertainment production
MSC Cruises and Explora Journeys will use the facility, which is expected to be ready in July.
Devils Rally Past Bruins in OT
It’s nights like these that make you wonder, what could have been. The New Jersey Devils certainly didn’t look like the hapless, directionless mess of a hockey team that spent the past three-plus months struggling to get out of its own way while plummeting to the darkest depths of the Eastern Conference standings. Well, maybe […]
Bull sharks make ‘friends’—and prefer females to males
The ocean’s bad boys don’t just cruise alone—they have preferred swimming partners.
Grapefruit vs. Grapefruit Juice: Which is Better for Immunity and Fiber?
Whole grapefruit and grapefruit juice both have substantial amounts of vitamin C. However, whole fruit is a better way to get antioxidants and fiber that your body needs.
MSC opening cruise entertainment studio in Edinburgh
MSC Creative Studios – MSC's new production studio in Edinburgh – will train performers for MSC Cruises and Explora Journeys.
UCLA secures No. 7 seed in Regional Bracket, faces UCF
The Bruins take on the UCF Knights in the first round.
MSC Group Developing New Entertainment Production Studio in Scotland for MSC Cruises, Explora Journeys
MSC Group is developing MSC Creative Studios in Edinburgh to enhance entertainment for MSC Cruises and Explora Journeys, with full operational capability expected by July 2026.
How Foreign-Trained Health Workers Saved the NHS £14 Billion
This blog is part of a series focused on the UK’s recruitment of foreign-trained health workers. This first blog details the amount of money the UK’s National Health Service (NHS) has saved by recruiting foreign-trained health workers. The second blog examines whether this saving is offset by foreign aid contributions to health systems strengthening (HSS) and human resources for health (HRH) in countries of origin.
UCLA men's basketball earns No. 7 seed, to face No. 10 UCF in Philadelphia
The UCLA Bruins will open the NCAA men's tournament against Central Florida in an East Regional game on Friday.
Astros vs. Marlins 3/15/2026 Spring Training Game Thread
The Houston Astros (8-10-3) host the Miami Marlins (8-10-2) in Grapefruit League play. RHP Cristian Javier is set to make his second start of the Grapefruit League. RHP Eury Perez will be on the mound for the Marlins. TODAY’S STARTER: RHP Cristian Javier is making his second start of the Grapefruit League this season. In […]
Norovirus outbreak sickens 153 passengers, crew on Caribbean cruise ship
More than 150 passengers and crew fell ill with norovirus during a Caribbean voyage aboard Princess Cruises’ Star Princess, the CDC says.
If students want to understand politics, they should start with Ancient Rome
The Roman Republic fell roughly 2,000 years ago — the culmination of a series of events including Julius Caesar’s assassination 2,069 years ago today. Yet the republic’s ruin still infl…
Researchers Upload Fly’s Brain to Matrix, Let It Control Virtual Body
A company claims to have simulated the neurons of an adult fruit fly's brain and letting it roam inside a Matrix-like virtual environment.
Wisconsin sets official visits with two class of 2027 lineman
A pair of lineman have set visits with the Wisconsin Badgers. Both are Class of 2027 recruits, though neither are in-state targets.
Emails reveal unseen maneuvering as Dallas debates City Hall’s future, business strategy
Messages show Economic Development Corp. CEO Linda McMahon pushing for a larger role and clashing with city leaders over corporate recruitment.
UCLA Faculty Association, science advocates host Stand Up for Science protest
Science advocates and UCLA Faculty Association members called on Californians to support a bill that would put scientific research funding on the 2026 ballot at a Saturday protest in Westwood.
How Boston mothers are turning burnout into political action
Chamber of Mothers is a national network with thousands of local parents pushing for child care, paid leave, and maternal health policies.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Nicole Kidman Names The Star Whose 'Bad Breath' Ruined Their Kissing Scene
“I have to recoil, yikes! I’m out. You could not offer me enough money,” the Oscar winner said.
Big 12 basketball tournament live updates, scores, results, how to watch: Arizona, Iowa State cruise to semis
Eating These 2 Surprising Fruits Every Day May Help Support Heart Health
New research found that eating mango and avocado daily may benefit certain heart health markers.
Her Lab Worked to Future-Proof Fruits and Vegetables
Erin McGuire ran a research network that studied how to get healthy food to marginalized populations around the world.
🚨 Marcel Ruiz injury sparks concern for the national team
It’s been a complicated week inside the Mexican National Team, as in addition to the loss of Luis Ángel Malagón, Marcel Ruiz has raised concerns after leaving the field at the Snapdragon Stadium....
HAL Makes Fleetwide Entertainment Updates in 2026
Holland America Line is updating its entertainment offerings throughout 2026, with new shows, the return of classical music, and more.
Can this Georgia fruit stand rebound after roadwork killed its business?
A legendarily misspelled fruit stand in the Georgia countryside south of Madison and I-20 is primed for a comeback after highway construction made stopping there a chore.
Kings lose in overtime to the Boston Bruins
Charlie McAvoy scored 39 seconds into overtime to earn the Bruins their 13th straight victory at home with win over Kings.
Fact-checking Trump's claim that Iran has Tomahawk missiles
Although a few countries other than the U.S. have Tomahawks, none of them is engaged in fighting Iran. Tomahawk cruise missiles are manufactured by Raytheon, a U.S. company, for use by the U.S. military and international partners.
WATCH: White House says Trump will accept outcome of investigation into bombing of school in Iran
White House press secretary Karoline Leavitt didn’t answer why President Donald Trump falsely asserted on Monday that Iran has access to the U.S.-made Tomahawk cruise missile, the weapon likely used to strike a girls school in Iran, killing 165 people.