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Who Are the Best Draft Picks in Denver Nuggets’ History?
The NBA Draft is where franchises, like the Denver Nuggets, are built. Few organizations have found greater value in the later stages of the draft than Denver. The team famously selected three-time MVP Nikola Jokić with the 41st pick in the 2014 NBA Draft. Now, the choice is regarded as the greatest second-round pick in […] The post Who Are the Best Draft Picks in Denver Nuggets’ History? appeared first on The Lead.
Jaylen Brown Releases First Statement On His Stunning Celtics Trade
Jaylen Brown's time in Boston is over. The former NBA Finals MVP was traded from Boston to Philadelphia in a stunning move on Wednesday afternoon. Brown is heading to Philadelphia, while Paul George, two first round picks and two second round picks are heading to Boston. The NBA world was ...
D.C. official tells Trump to build his arch somewhere else
The city’s historic preservation officer criticizes the president’s plan to build his towering arch in Memorial Circle, suggests the administration should pick a spot near Nationals Park.
2026 Phillies MLB Draft Preview: Caden Sorrell, OF
Just as I was trying to figure out who to write up next, Baseball America popped out their 5th mock draft, this time with a new name as the Phillies pick. It doesn’t sound like there’s sourcing for this or actual rumors of Phillies interest so much as there is “It’s the 36th pick. Who […]
MLB Predictions and Moneyline Picks for Thursday, July 2
Colby Marchio’s MLB moneyline leans and insights for Thursday, July 2, featuring the Los Angeles Angels.
Ford reports Q2 sales down 10% as it transforms the business
Ford reported a decline in Q2 U.S. sales as commercial fleet sales pulled back and pickup production struggled to catch up after a fire at a supplier.
Steelers' Defensive Line Future Hinges on Keeanu Benton Contract Decision
For the first time in what feels like a very long time, the Pittsburgh Steelers are getting second deals done with their draft picks. Joey Porter Jr. is in line for his deal, Darnell Washington got his, and Nick Herbig also cashed in during the 2026 offseason. According to a Steelers insider, the team may leave 2023 second-round pick Keeanu Benton on the outside looking in.
Yankees news: Judge calls out “lack of focus”
The captain’s rebuke; illness strikes the clubhouse; Grisham in NJ; Goldschmidt left on bench in loss; Futures Game picks
Photo Gallery: Dev Camp Roll Call Part Two
Witness top picks and hungry invitees from Sweden to Ontario as they hit the ice in Seattle, showcasing the next generation of talent fighting for a roster spot.
Sobble Community Day: Your Go-To PvE Guide
Sobble Community Day makes Inteleon a strong Water-type raid attacker with Hydro Cannon and a valuable future pick for Max Battles.
The Herald's weekly entertainment picks
Looking to be entertained from Thursday, July 2, through Wednesday, July 8? Check out the Skagit Valley Herald’s weekly recommendations.
Jadarian Price Will Own the Seahawks' Backfield Sooner Than Later
Despite any early info to the contrary, the Seattle Seahawks didn't spend a first-round pick on running back Jadarian Price just to make him an afterthought in their offensive attack.
Red Wings Acquire Keegan Kolesar in Trade with Golden Knights
The Detroit Red Wings have acquired forward Keegan Kolesar from the Vegas Golden Knights in exchange for future draft picks.
World Of Warcraft Is Finally Fixing Its Stupidest Settings Problem
I do not have time to pick up all of these Rust-Covered Blunderbusses
Crooked Letter Sports: We’ve got World Cup (and golf) fever | Ep. 303
As the World Cup moves to the Knockout Rounds, we take a look at the most exciting games so far and pontificate on the USA’s chances. Plus, Scottie Scheffler finishes second (again) and Rick picks his favorite Mississippi courses.
Indie Selects for July 2026: Gameplay That Will Make Summer Pop
The ID@XBOX team has handpicked five Indie Selects for July that are ready to light up your night like a sky full of summer fireworks.
2026 NFL WR dynamic duo rankings: Cowboys' Cee Dee Lamb-George Pickens tandem among elite
Which NFL team has the best pair of wide receivers?
Should Value Investors Buy Accel Entertainment (ACEL) Stock?
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
This satellite constellation transformed earth science by creatively tuning in to GPS signals
Key takeaways —The first constellation to produce high-quality data by picking up GPS microwaves reflecting off Earth, called CYGNSS, is featured in the Smithsonian National Air and Space Museum's Living in the Space Age exhibit. —Distortions in the reflected signals can reveal information about Earth, including hurricane wind speed and the distribution of moisture in soil, and the constellation provided unprecedented coverage in both time and space. —GNSS-R data is useful for mon
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
Colorado voters pick state Senate primary winners
Colorado voters on Tuesday night picked winners in the Republican and Democratic primaries in an election that will shape the contests in the general election later this year. The eventual winners will join the Colorado General Assembly in January 2026. Here are the results in key districts. Senate District 3 Colorado voters appear to be […]
Colorado primary election results: Melat Kiros leads Dianne DeGette in congressional race
Here are the early, unofficial results as of 7 p.m. • In the 1st Congressional District, challenger Melat Kiros is leading U.S. Rep. Diane DeGette, 47%-45% • In the U.S. Senate race, U.S. Sen. John Hickenlooper is leading challenger Julie Gonzales, 51%-49% Colorado voters head to the polls today to pick primary winners that will […]
The Best Small-Business Accounting Software
We identified the accounting software providers that add value to your bottom line.
Google pulls the plug on Tenor API, killing GIF pickers around the web
GIFs are a huge part of the modern web, with Tenor being one of the libraries that powers a variety...
Are Investors Undervaluing Inspired Entertainment (INSE) Right Now?
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
Colorado voters head to the polls today — check here for regular updates
Colorado voters head to the polls today to pick primary winners that will vie for statewide offices in November, the result of which would determine the direction of the state in the coming years. At stake are the parties’ nominees for U.S. senator, governor, attorney general and several statewide offices, along with races for Congress […]
Who should be Faber Builders Girls Athlete of the Spring?
It's time to pick the top athlete from the spring high school season.
Not many ‘Iron Men’ are left in Major League Baseball
Pete Alonso played his 500th consecutive game this week, although if he wanted that to seem impressive to local fans, he probably picked the wrong city to play in. Alonso, of course, joined the Baltimore Orioles this past offseason. Their franchise record for consecutive games is also the big league record of 2,632 by true […]
Mavericks' Dusty May declares Morez Johnson Jr. as favorite Wolverine
Mavericks coach Dusty May expressed excitement about working with Morez Johnson Jr. again after the team drafted him with the ninth overall pick.
Terrion Arnold released: Where Lions go from here after secondary suffers loss, plus potential replacements
The Lions cut ties with their former first-round pick after his arrest on kidnapping and armed robbery charges, leaving a void in Detroit's secondary.
Wings' Azzi Fudd achieves 29-year WNBA history
Fudd was the No. 1 overall pick and is trying to prove it was worthy.
Ravens Rookies Expected to Make Immediate Impact in ‘Projected Roles’
The Baltimore Ravens are known for drafting players who can make an immediate impact on the field. For example, look at Kyle Hamilton.Hamilton is already a three time All-Pro after being drafted by Baltimore in 2022. In this year’s draft class, Baltimore’s draft picks have the same potential to make an immediate impact as soon […] The post Ravens Rookies Expected to Make Immediate Impact in ‘Projected Roles’ appeared first on HEAVY.
NBA vet Malik Beasley, former player Ed Davis indicted on illegal sports gambling charges
Beasley is a former first-round draft pick and nine-year NBA veteran. Davis played for eight teams, ending in 2021-22.
Why ‘Cyberpunk 2077’ Just Hit Its Highest Playercount In 2.5 Years
Cyberpunk 2077 is climbing the Steam charts 5.5 years after its release, and it's a great time to pick it up if you haven't.
The State of Politics: The Politics of Lt. Governor Position
The governor doesn't pick the lieutenant. And they often don't get along.
Passback finds new life for old sports equipment, equipping youth to take the field
Magdalen Sparrow grew up on St. Louis’ soccer fields chasing after stray balls and picking up lost water bottles to put in overflowing lost and found bins. Then known by her maiden name, Magdalen Pike, she went on to play D1 soccer at Southeast Missouri State University, accumulating a closet full of sports gear in […]
What to Stream: 'Enola Holmes 3,' Madonna and the 'Legally Blonde' prequel series 'Elle'
New streaming entertainment options for the week of June 29 include “Enola Holmes 3" and a new Madonna album. The Associated Press highlights some top picks. “Obsession,” a film with
Eagles Fifth Round Pick Being Viewed as Next Brock Purdy
If there's one guy I trust around the NFL, it's Howie Roseman. Roseman, who has continued to prove that he can find talent at a very high level at any given moment, is hopeful that he did so in the NFL Draft once again with his fifth-round pick of Cole Payton.
Seahawks Get Big Rashid Shaheed Update Ahead of Training Camp
The Seattle Seahawks have Jaxon Smith-Njigba as their WR1, but the question will be whether Rashid Shaheed can become a WR2. Last season, the Seahawks traded a fourth-round pick and a fifth-round pick in the 2026 NFL Draft to the New Orleans Saints for Shaheed. Moreover, Shaheed didn’t become a rental for the Seahawks, as […] The post Seahawks Get Big Rashid Shaheed Update Ahead of Training Camp appeared first on HEAVY.
Miles Bridges trade grades: Suns burn another potential rebuild year, Hornets add to draft pick pile
The asset-rich Charlotte front office got a home run return with the 2033 first-round pick
Kings’ Acuff Jr., Nets’ Brown Jr. Rivalry Continues in NBA
From high school shootouts to collegiate clashes, these elite lottery picks bring a storied history to the pros as they prepare to ignite a cross-conference professional feud.
Penguins organizational outlook heading into free agency
It ended up being a mostly uneventful draft weekend for the Pittsburgh Penguins. They acquired Hendrix Lapierre for draft picks, used some of their stockpile future of picks to get extra 2026 mid-round selections and went about their business of drafting players without many fireworks going down with massive moves. The big landmark for the […]
Suns trade Grayson Allen, Royce O'Neale for Miles Bridges
The Suns have agreed to trade two key rotation players and a 2033 first-round pick for Hornets forward Miles Bridges and future draft capital.
Hornets reportedly trading Miles Bridges to Suns for Grayson Allen, Royce O'Neale, 1st-round pick
Charlotte continues its offseason overhaul after nearly making the NBA playoffs this past season.
Habs Daily: Canadiens Draft Picks, Focus On Physicality, Trades
Here are the Montreal Canadiens and NHL news items you may have missed on a very busy NHL Draft weekend. […]
Slate is betting Americans want less car for less money
Slate unveiled the starting price for its tiny, electric pickup truck this week. It's betting that today's overly techy cars created a white space.
Our picks for the best things to do in Cincinnati this week, June 29-July 5
If you're wanting to see some fireworks this week, we've got you covered. Find an event in your community to celebrate Independence Day.
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
Hurricanes Acquire Rights to John Carlson
It had been a long day. Some teams were using all of their allotted time, even in the later rounds to make their draft decisions. Then came Carolina, and time had expired while the world waited for them to make pick number 192 in the Draft. What happened? Eric Tulsky and company smacked everyone in […]
NBA No. 1 pick AJ Dybantsa throws first pitch before Yankees-Red Sox game, lobs eephus pitch for a strike
The Orlando Magic Waive Defensive Versatile Forward Jonathan Isaac
The Orlando Magic severs ties with the former lottery pick to avoid a looming salary guarantee, ending an injury-plagued nine-year tenure while seeking financial flexibility for a critical offseason.
Bruins draft Russian forward with 104th overall pick
The Bruins have selected multiple Russians in a draft for the first time in almost 25 years following their fourth-round selection Saturday.
Bruins draft goalie Yuri Ivanov with second-round pick
The Bruins went with a goalie with their first pick of the 2026 NHL Draft.
Flyers continue to add on defense with first of two second-round picks
With their first of two second-round picks in the 2026 NHL draft, the Flyers selected Brek Liske.
Bill Barr says Todd Blanche isn't 'a toady,' urges senate to confirm Trump's AG pick
Bill Barr argues Todd Blanche's relationship with Trump is a strength, urging Senate Republicans to confirm him as attorney general amid GOP reservations.
Phillies vs Mets Prediction, Picks & Odds for Today's MLB Game
The Phillies have been hot, and our expert MLB predictions expect their winning ways to continue against the lowly Mets.
Church pickles in dry storage, warm fish in restaurant inspections
See scores from local Lane County eateries in this week's write-up of restaurant inspections.
NHL Rumors: 3 Red Wings Who Could Be Traded Next
The Detroit Red Wings made a notable trade on Friday, as they traded top goalie prospect Sebastian Cossa to the Utah Mammoth in exchange for the 23rd overall pick of the NHL Entry Draft. The Red Wings then used that pick to select forward J.P. Hurlbert.Seeing Cossa get traded by the Red Wings is not […] The post NHL Rumors: 3 Red Wings Who Could Be Traded Next appeared first on HEAVY.
Pro-Israel influencers criticize Vance, but evangelicals remain open to him
Despite attacks from some conservatives, a heavily pro-Israel crowd still has warm words for Vance, with many saying they could pick him as the party’s nominee.
Ducks move into first round, select skill in Klepov, Nordmark
Anaheim jumped back into the first-round with two picks acquired in the Mason McTavish deal, and the Ducks went for scoring punch in Nikita Klepov and Marcus Nordmark.
Rangers Land 37-Goal Star In Blockbuster Trade With Vegas
The New York Rangers have added a new star forward to their roster.According to TSN’s Darren Dreger, the Rangers have acquired forward Pavel Dorofeyev from the Vegas Golden Knights.Sportnet’s Elliotte Friedman later added that the Rangers are sending the 26th pick of the 2026 Entry Draft, the 92nd pick of this year’s draft, and their […] The post Rangers Land 37-Goal Star In Blockbuster Trade With Vegas appeared first on HEAVY.
Sabres acquire defenseman Olen Zellweger from Ducks for 2nd round pick, prospect
It's been a busy week for the Sabres.
A new “Supergirl”, the end of “The Bear”, and a fisherman thriller top this week's Must List
Book of Love's 40th anniversary album and "Dad Don't Read This" round out our picks for the weekend of June 26.
Thunder reportedly trade Isaiah Joe to Pistons for two second-round draft picks
Isaiah Joe still has two years left on his contract.
Best Prime Day deals 2026: Amazon's summer sale ends today
We're into the final hours of Prime Day. Don't miss out on our deal highlights from our top-tested picks.
Last Chance: Best Nintendo Switch & Switch 2 Prime Day Deals at Amazon (Final Day)
It's the final day of Amazon Prime Day, and if you've been waiting to pick up Nintendo Switch or Nintendo Switch 2 games, accessories, or hardware, this is
Penguins Mocked To Select 81-Point Defenseman
Pittsburgh has the 22nd overall pick in the 2026 NHL Draft.
2026 SEC football predictions: Game-by-game picks, projecting every team's final win-loss record
Continuing our early-summer projection series for all 16 teams in the SEC and where they'll end up in the postseason
2026 NHL Mock Draft
Ahead of tonight’s NHL draft, let’s take a stab at how the first round could play out tonight. First, a moment of silence for our near miss last year – when we tried to predict that Kyle Dubas would go ‘off the board’ with a high pick on a WHL center that no one saw […]
Slate's $24,950 EV truck is tiny and ridiculously customizable
Slate's pickup truck just revealed its sub-$25k price. So we tested out its build-your-own tool to see how the accessories work.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Clippers draft pick Narcisse Ngoy announces he will play at Auburn next year in unique draft-and-stash situation
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Best Prime Day Oura Ring deals: Get a record-low price
The Oura Ring 4 is our pick for the best smart ring on the market, and it's getting an excellent Prime Day deal.
Prime Day Smartphone Deals Are Live: Save Up to 44% on Samsung Foldables, Google Pixels, Motorolas, and More
These are the Amazon Prime Day smartphone deals actually worth buying, featuring editor-approved picks from Samsung, Google, Motorola, and more.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Top Weekly Entertainment Picks
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Looking to be entertained from Thursday, June 25, through Wednesday, July 1? Check out the Skagit Valley Herald’s weekly recommendations.
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