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David Bride: Small business investment could fuel resident interest
As mayor, I would focus on giving small businesses practical support. That means connecting entrepreneurs with public funding, private investment, banks and community organizations.
New movies to watch this weekend: See 'Primetime' and 'Heart of the Beast' in theaters, rent or buy 'Super Troopers 3,' stream 'Tuner' on Paramount+
In theaters now: Robert Pattinson wows in his turn as "To Catch a Predator" host Chris Hansen — and don't underestimate the power of Brad Pitt and a dog.
Pioneer of China NewCo model sued in US over trade secret misuse, double-dealing
A legal feud unfolding in New York is putting a spotlight on the work of a business development veteran who is credited for pioneering one of biopharma’s hottest dealmaking mechanism: the China “NewCo” model. In a lawsuit originally filed in New York state court and recently moved to federal court, China’s Lepu Medical Technology has alleged that biopharma business development consultant Su Zhang, who was hired to help shop its GLP-1 weight-loss candidates to Western partners, engaged in corporate double-dealing and trade secret leaks. According to the complaint, while acting as Lepu’s primary dealmaking liaison for a group of obesity and metabolic disease drug candidates, Zhang was secretly double-dipping as the acting chief business officer for a direct competitor, BrightGene Pharmaceutical. “She never adequately disclosed the role, never sought Lepu’s consent, and never proposed any safeguard,” Lepu alleged in its complaint, which was filed in July after Zhang’s consulting firm, CoDevCo, sought certain transaction-based success fees from its angry customer through an arbitration process in Singapore. Lepu, the parent company of Lepu Biopharma, has asked Zhang to pay back its $500,000 retainer and disgorge all benefits she received during the alleged breaches of fiduciary duty, plus other damages and relief. The company has also requested the court grant injunctions to protect Lepu’s trade secrets. The ill-fated partnership officially kicked off in December 2024, when Lepu tapped CoDevCo as its “exclusive business development mechanism” to identify collaborators for the company’s drug candidates. According to Lepu’s complaint, Zhang personally negotiated and signed the agreement as managing director for CoDevCo, which used her home address. Before the Lepu deal, Zhang made a name following a short stint as the global head of business development for Hengrui Pharmaceuticals. It was during her tenure that Hengrui signed a landmark deal granting exclusive rights for a portfolio of GLP-1 assets to Hercules, which was at that time newly established by a group of private equity and venture capital firms. In addition to the regular upfront and milestone payments, Hengrui also gained an equity stake in Hercules, which later became Kailera Therapeutics. The Hengrui-Hercules deal opened a new paradigm, where a Chinese biopharma company spins off certain early-stage assets to investors for further development through the creation of a new company abroad. The “NewCo” model quickly came into vogue as it allows Western investors to access high-potential assets originating from China at an early stage while giving the Chinese licensors an opportunity to reap long-term benefits through equity stakes in the new firms. The NewCo model proved its value when Kailera staged a record-breaking $625 million IPO on Nasdaq this April, merely two years into the Hengrui deal. Related Kailera CEO 'knew we were in a good spot' before obesity biotech's record-breaking $625M IPO On her LinkedIn page, Zhang described her work at Hengrui as “[b]uilding team and capability from the ground up,” forming NewCo and major pharma partnerships worth billions of dollars. Lepu clearly wanted that kind of track record to help boost its own cardiometabolic portfolio, which includes a range of assets for obesity, Type 2 diabetes, fatty liver disease and muscle preservation during weight loss treatment. “Lepu’s pipeline is very valuable, but only if Lepu could secure the right international partner to expand into the overseas market during the available commercial window,” the company argued in its complaint. The Chinese biotech said it had little knowledge of U.S. laws, customs or business practices in the business development field, and therefore “needed to rely entirely” on the expertise of Zhang and her team as the firm’s first engagement of a U.S.-based BD consultant. “Zhang’s dominating influence on the business development strategy is further evidenced by the fact that she personally controlled the business-development communications on behalf of Lepu with potential partners,” Lepu said in its complaint. After entering the deal, Zhang introduced Lepu to her four associates. According to Lepu’s version of events, all of them were allegedly employed at different time points to perform similar jobs at other Chinese companies that Lepu described as its competitors, while having access to Lepu’s confidential information. As such, Lepu described Zhang’s team as “a roster of individuals whose primary professional loyalty, by virtue of their concurrent full-time employment, ran to Lepu’s competitors.” As well as the specific examples set out in the case, a look at Lepu’s deals over the period suggests Zhang may have been involved in at least one transaction. During their partnership, Lepu, through its subsidiary Shanghai Minwei Biotechnology, also out-licensed its GLP-1/GIP/FGF21 agonist MWN105 to a NewCo called Sidera Bio in the fall of 2025. The deal included an upfront and near-term payment of $35 million, up to $1.01 billion in milestones, and a 9.99% stake in the Danish startup. It seems likely that Zhang facilitated the Minwei deal given that Lepu is on record as having used CoDevCo as its “exclusive business development mechanism.” The big shock for Lepu came in the form of a news article on June 25, 2025. The article, reporting on phase 2 data for BrightGene’s GLP-1/GIP receptor agonist BGM0504, identified Zhang as acting chief business officer of the Lepu rival. Blindsided by her association with BrightGene, Lepu confronted Zhang in July 2025. “Lepu was given assurances that there was nothing to be concerned about and told that Zhang would explain the matter to Lepu,” Lepu alleged in its complaint. “Zhang never did.” Lepu claimed that Zhang had the motive and opportunity to steer potential prospective partners toward BrightGene or other competitors. Later, in February 2026, one of Zhang’s associates joined BrightGene as the vice president for global business development, according to the complaint. Around the same time, Lepu sent written demand letters asking Zhang to account for her BrightGene role, identify what confidential data were shared with the rival firm, and provide any conflict-of-interest or firewall policies during the engagement. According to Lepu, neither CoDevCo nor Zhang answered the questions in their responses. Related Novo vs. KBP: How a $1.3B deal turned into a fraud accusation and an international legal fight In a motion to dismiss filed with the U.S. District Court in the Eastern District of New York on Sept. 4, Zhang’s legal team argued that Lepu’s agreement was signed with CoDevCo, and that an employee of the contractor does not owe fiduciary duties to the client. In its complaint, Lepu said: “That CoDevCo was the contracting entity does not insulate Zhang from personal liability for duties she personally undertook and personally breached.” Taking the argument one step further, the defending party argued that the consulting agreement “does not create a fiduciary relationship even between CoDevCo and Lepu; instead, it identifies CoDevCo as an independent contractor retained to market Lepu’s business to potential western partners.” Although CoDevCo was Lepu’s exclusive business-development contractor, there were no terms stipulating that the consulting firm should serve only Lepu, Zhang’s lawyer noted. As to Lepu’s claims that Zhang misappropriated trade secrets, the defendant argued that Lepu authorized the use of the information so Zhang’s team could perform their service per the agreement. In a rebuttal filed on Sept. 11, Lepu’s lawyer set out why they believe the Chinese biotech satisfied New York law’s misappropriation definition by alleging that the defendant used a trade secret “in breach of a duty or through improper means.” As an alternative to dismissing the suit, the defendant suggested the action should be stayed pending outcomes from the arbitration of a separate case in Singapore. While NewCo pioneer Zhang is defending her business arrangements, momentum behind the NewCo trend has continued unabated into 2026. Through August, Chinese biotech assets have spurred 15 NewCo deals this year, according to local trade publication PharmaDJ.
Juventus is interested in a move for Manchester City star
Rayan Ait-Nouri was one of the finest left-backs in Europe during his time at Wolves, and the defender demonstrated his quality in numerous matches, prompting Pep Guardiola to sign him for Manchester ...
Here are the midterm polls that caught our eye this week.
Another round of interesting midterm polls this week find an electorate dissatisfied with President Donald Trump and mostly souring on Republicans in marquee races.
Maintaining their own health: Support group offers rest for dementia caregivers
Caregiving is hard, and caregivers need support to continue in this demanding role for days, months and even years.
Braves Boss Threatens Nashville MLB Expansion, ‘Our Territory’
The Atlanta Braves’ CEO offered a one-word response on Nashville’s interest in hosting an MLB franchise, shortly after a $97 million update.
Trump picked a fight with the media... and lost
Jonathan Freedland speaks to the Guardian’s Shrai Popat about why Trump seems weaker these days, and why it could be dangerous to underestimate him
Wall St Week Ahead Jobs report, inflation data to test US rate path, economic strength
Investors will sift through reports on employment and inflation in the coming week to assess chances of a sharper trajectory of interest rate hikes, which could undermine the US stock market's rally.
Wilonsky: Dallas’ plate of entertainment, shot of enforcement
Dozens of venues claiming they’re really restaurants are being cited by Dallas City Hall for being bars.
Some dementia patients grow lucid near the end. Scientists hope it’s a clue.
Accounts raise tantalizing questions about what happens inside a brain afflicted by dementia and whether cognitive abilities could possibly be restored.
Many Health Care Grad Students Can’t Get the Loans They Need
New federal loan limits restrict borrowing for graduate degrees in many fields, and prospects for private loans are also grim.
North Carolina restores perinatal program after Medicaid funding dispute delayed research
Perinatal Quality Collaborative revives projects on newborn screenings and maternal mental health to launch in 2027, officials said.
But that’s when things got interesting. Redick had a …
But that’s when things got interesting. Redick had a …
Gasperini schedules team dinner
Gian Piero Gasperini has granted four days of rest to the players who remained at Trigoria: from Svilar to Malen, who is recovering from knee problems. Their return to the field is scheduled for Tuesd...
The sun has set on a fantastic edition of the FISU Beach Sports Championships
The Figueira da Foz Buarcos Beach has seen the best beach soccer, handball, wrestling and volleyball student-athletes from the world compete on its sand over the last seven days. What a great way to say goodbye to the Portuguese summer! Almost from sunrise until sunset, student-athletes from all over the world jumped, kicked, ran and […]
New Business Licenses: 9.25.26
Chesterfield and Henrico report restaurants, janitorial services, two dental practices and more. (BizSense Pro required)
Real Madrid Prepare To Reignite Interest In Ajax Star
Real Madrid are reportedly preparing to reignite their interest in Abdellah Ouazane.
Nebraska softball to begin fall season against Kansas
Husker softball is kicking off their season on Sept. 26 at Bowlin Stadium against the Kansas Jayhawks. Most of the team is made up of rookie freshmen so it will be interesting to see how they play.
Verrado Marketplace announces next wave of businesses opening this year
When fully completed, Verrado Marketplace will house more than 55 retailers, restaurants and service providers.
Bellingham's business closures more of a churn than a trend, industry onlookers say
Full-service restaurants hurting most. But when one place closes, another opens up
SCIENCE-BATS/
Indian flying foxes or fruit bats rest on tree branches Feb. 3, 2022, inside a temple complex at Kadambazhipuram village in Palakkad district in the southern state of Kerala, India.
SCIENCE-BATS/
Indian flying foxes or fruit bats rest on tree branches Feb. 3, 2022, inside a temple complex at Kadambazhipuram village in Palakkad district in the southern state of Kerala, India.
SCIENCE-BATS/
Indian flying foxes or fruit bats rest on tree branches Feb. 3, 2022, inside a temple complex at Kadambazhipuram village in Palakkad district in the southern state of Kerala, India.
SCIENCE-BATS/
Indian flying foxes or fruit bats rest on tree branches Feb. 3, 2022, inside a temple complex at Kadambazhipuram village in Palakkad district in the southern state of Kerala, India.
SCIENCE-BATS/
Indian flying foxes or fruit bats rest on tree branches Feb. 3, 2022, inside a temple complex at Kadambazhipuram village in Palakkad district in the southern state of Kerala, India.
Brother of Hayden Panettiere's boyfriend resolves court case after arrest
Zach Hickerson, brother of late actress Hayden Panettiere's boyfriend Brian Hickerson, has resolved a case that landed him behind bars earlier this month.
Hannah Einbinder, Susan Sarandon arrested in protest against Netanyahu
Hannah Einbinder and Susan Sarandon were arrested after protesting the arrival of Israeli Prime Minister Benjamin Netanyahu at the United Nations in New York City. Cynthia Nixon, Elliot Page, Indya Moore, Mary Beth Barone, Caleb Hearon and Sarah Sherman were also at the demonstration.
Health care workers join national push to protect immigrant caregivers
Members of 1199SEIU and community allies called on Congress to restore legal protections for immigrant workers and warned that deportations and federal cuts are straining hospitals, nursing homes and home care.
Senate bill on college athletics won’t ‘save’ NCAA sports, Sam Acho says
ESPN analyst Sam Acho discusses his perspective on the Senate bill aimed at restructuring college sports.
Interested in purchasing a commercial space through the Business Community Ownership Fund?
Our Business Community Ownership Fund has two brand-new, cold-shell commercial spaces in Rainier Valley available to match with a business owner. If you’re interested in the spaces below, please visit our website for more details on eligibility and reach out to our program staff at OED_BCOF@seattle.gov. Available commercial spaces (9/24/26): Atrium Court, 7324 Martin Luther […]
UConn Football Gets Interesting Schedule Wrinkle For Near Future
While the Huskies are taking on Miami (Ohio) this weekend, they learned something about their 2029 schedule earlier this week.
At least 30 arrested, including actors, politicians during anti-Netanyahu protest outside UN
Police arrested at least 30 people, including actors and politicians, during a protest outside the United Nations headquarters on Thursday against Israeli Prime Minister Benjamin Netanyahu, hours before he addressed the UN General Assembly.
Oregon political leaders demand emergency federal assistance for East Evans Creek Fire
Initial request was denied in late July; fire was sparked by a rollover crash in which a teen driver has been arrested Multiple Oregon federal lawmakers are requesting that the […]
Reducing the $2T federal deficit could lower inflation, interest rates for Americans: CRFB
Curbing the federal government's roughly $2 trillion budget deficit could lower inflation and current interest rates for households, a CRFB report finds.
Downtown Round Rock business rebrands as Alcove, opens expansion
The bar and restaurant formerly known as Sociedad rebranded to its original name of Alcove, owner Michelle Ly confirmed in September.
Police arrest actors, politicians protesting against Netanyahu outside UN
By Maria Tsvetkova NEW YORK, Sept 24 (Reuters) - Police arrested at least 30 people including actors and politicians as they protested outside United Nations headquarters on Thursday against Israeli
Police arrest actors, politicians protesting against Netanyahu outside UN
Police arrested at least 30 people including actors and politicians as they protested outside United Nations headquarters on Thursday against Israeli Prime Minister Benjamin Netanyahu ahead of his speech at the General Assembly.
Bill seeks to restrict development of artificial superintelligence
The bill would ban artificial superintelligence, which it defines as AI models with cognitive capabilities that surpass those of humans and have the ability to destroy humanity.
Trump urges Supreme Court to restart deportations to countries with poor human rights records
President Donald Trump’s administration urged the Supreme Court on Thursday to allow it to remove migrants to countries other than their homeland without giving them an opportunity to raise human rights concerns.
Trump Administration Asks Supreme Court to Allow Deportations to Third Countries
A lower federal court on Wednesday imposed restrictions on deporting migrants to countries other than their own.
Juventus remains interested in signing Danish attacker
Juventus have been following Conrad Harder since he played for Sporting Club, where he was one of the best players in their team before moving to Germany to play for RB Leipzig. The Bianconeri have co...
Democratic House candidate arrested during Netanyahu protest in NYC
Darializa Avila Chevalier was among several progressive elected officials and nominees who protested Netanyahu's speech at the U.N.
Conflict mapping research group founded by OSU researcher wins national award for open science
The American Geophysical Union has awarded the 2026 Open Science Recognition Prize to the Decentralized Damage Mapping Group, an international research team co-founded by Oregon State University Professor Jamon Van Den Hoek and postdoctoral scholar Corey Scher.The prestigious award is in recognition of DDMG’s contributions of satellite mapping data of regions beset by war, conflict or natural disasters to the public sphere, particularly to aid in humanitarian response and provide journalists with up-to-date information.
Netanyahu says Mamdani endangers Jewish New Yorkers
The mayor has encouraged the federal government to arrest Netanyahu.
Western Ranch Motor Inn sells business; bar and restaurant closing for extended-stay plan
The restaurant and bar inside the Western Ranch Motor Inn is closing.
Housing geared toward low-income families opens in Detroit
A group of developers and city officials on Thursday celebrated the opening of Preston Townhomes, a $14 million affordable housing project in the Islandview neighborhood.
Edinburg Woman Arrested in Connection with Fatal McAllen Overdose
The McAllen Police Department has Arrested Vanessa Denise Rico, 48 years old, of Edinburg, Texas, on two (2) counts of Manufacture or Delivery of a Controlled Substance following an investigation into the death of a 39-year old McAllen man.
Why Australia chose the world's biggest political stage to reveal OpenAI hack
Australia, which has strict social media restrictions and has proposed controls on algorithms and smart glasses, announced the breach at the UN.
Lawmakers Introduce 20-30% Federal Film Incentive
Lawmakers have introduce da 20%-30% stackable film incentive in a bid to restore domestic production.
Ex-NC State sports medicine director arrested after accusations of sexual abuse
More than 30 former NC State athletes have accused Robert Michael Murphy Jr. of sexual abuse.
How Inter are planning to replace Hakan Calhanoglu
Serie A side Inter haven’t quite made progress in their attempts to renew Hakan Calhanoglu. Turkish interest has constantly lingered around the midfielder, which isn’t helping the situation whatso...
Lancaster County small businesses, private nonprofits impacted by drought eligible for low-interest loans
Low-interest federal disaster loans are available for small Lancaster County businesses and private nonprofits impacted by drought earlier this year.
"It genuinely breaks my heart"- Confusion and frustration reign as gaming communities react to Xbox's drastic restructuring this week
Rare, Obsidian, Age of Empires, and Ninja Theory communities are reckoning with the fallout from Xbox's latest restructuring.
Dolly Parton’s sister addresses family feud rumors amid nephew restraining order
Dolly Parton’s sister Freida has addressed a rumored rift among the family after the late country singer’s estate was granted a temporary restraining order against her nephew Bryan Seaver. “I’ll
Toronto Blue Jays Interested in Next Japanese Baseball Phenom
Shoki Koda is an 18-year-old phenom from the Japanese high school ranks.
Sony, A24 and the New York Times Company Circle Letterboxd
A24, Sony and The New York Times Company all registered their interest in acquiring the cinephile’s paradise.
5 Takeaways From a New Poll on the New Hampshire Senate Race
Representative Chris Pappas, a Democrat, leads by five percentage points, according to a New York Times/Siena poll. Voters say they are more interested in a check on President Trump than in a candidate who supports him.
Local Mexican restaurant, Azul, closes after 19 years in business
(FOX40.COM) — Beloved Mexican restaurant Azul is closing its doors after 19 years in business, according to a social media post. The owner posted on the restaurants Instagram on Wednesday thanking …
Important Games to watch: Week 4
Week 4 is here and important SEC Matchups this week can have some major implications for the rest of the season
Giants reportedly pursuing Jimmy Garoppolo after Jaxson Dart injury
Couuld there be mutual interest between the Giants and the veteran quarterback?
Judge orders White House to restore access to CNN, MS NOW and Politico. Reporters say they're still blocked
The back-and-forth is the latest in an extraordinary showdown between Trump and media outlets whose coverage he dislikes.
Square Integrates Apple Business to Help Local Businesses Stand Out on Apple Maps
DISTRIBUTED-WORKFORCE/OAKLAND, Calif., September 24, 2026--Square today announced a new integration with Apple that enables Square sellers to connect their locations to Apple Business from their Square Dashboard, so they can seamlessly manage and synchronize key business location information that appears on Apple Maps. Rather than managing multiple channels separately, sellers can now maintain their Apple presence alongside the rest of their business in Square. The integration makes it easier fo
Roma interested in Kvernadze and Bakola for January
The right-footed left winger Roma has been seeking since Gasperini’s arrival could be just 90 kilometers away. After seeing a long list of targets fall through, from Summerville to Leweling, the Gia...
New bag restrictions at Prudential Center anger Devils fans
All bags larger than 4″ x 6″ x 1.5″ are prohibited at the arena.
Nashville nightclub owner, 2 others charged with arson after business damaged by fire in May
Arrest documents show that all three people were present the night that La Danse nightclub burned down.
Nightclub owner, 2 others charged with arson after business was destroyed by fire in May
Arrest documents show that all three people were present the night that La Danse nightclub burned down.
Is metascience being co-opted?
In July, the White House released a report that argued academia is deeply dysfunctional and in need of radical reform.Science: A New Golden Age sets out a litany of problems many academics will recognise: interminable waits for grants; short-term funding rather than support for longer, more ambitious projects; ballooning administrative requirements; pressure to publish, and many more. “The scientific machine is getting bogged down,” it says. At least on the face of it, Science: A New Golden Age is a triumph for the metascience movement, a loose-knit, global group of academics, philanthropists and think tankers that want far more testing and experimentation in how we fund public research and innovation. The report tells US research funders to set up internal metascience units to do just this. But it has also set alarm bells ringing that metascience is being conveniently deployed to help justify the defunding of US universities, which US vice president JD Vance has openly labelled “the enemy.” “Just because you have an issue with your plumbing in your house doesn't mean you light the entire house on fire and burn it to the ground,” said Colette Delawalla, chief executive of Stand Up for Science, a group campaigning against what it says are attacks on scientists by the Trump administration. No one is arguing that academia doesn’t need reform, but there’s debate over how far and how fast the system should be shaken up. Does public R&D need slow and steady evidence-based adjustment, or radical new experiments?One of the key arguments in Science: A New Golden Age is that there’s not enough funding for what it calls “mid-level” science: engineering-heavy projects that require tens of millions of dollars, involve ten to a hundred people, and last around five years. Such a project might develop a brain-computer interface for people with Alzheimer's disease, for example. As such, the US National Science Foundation (NSF) has already announced $1.5 billion to set up so-called X-Labs, effectively new research organisations to pursue breakthroughs in areas such as quantum sensing and new scientific instruments. Funding divertedBut there’s a catch: this money has squeezed NSF budgets for more traditional, fundamental research grants, Science reported in June, likely meaning less cash for university-based scientists. Science: A New Golden Age also makes various swipes at universities, accusing them of extracting overheads from scientists to fund administrative bloat. “We have become dependent on a narrow set of legacy institutions,” it says. The report doesn’t mention it, but the US government is simultaneously seeking greater powers over federal funding, which would allow political appointees at funding agencies to screen or cancel research grants mid-project. The White House is also seeking to slash the NSF’s budget by more than half in 2027, although similar cuts proposed for 2026 were blocked by Congress. Convenient hookThis has worried some that the metascience agenda could be misused as a kind of smokescreen to further weaken universities. James Wilsdon, executive director of the Research on Research Institute at University College London, said that the report contains lots of “interesting ideas” and agrees that in places, academia is a “pretty broken system.” But the risk is that metascience is being deployed as a “convenient hook” to support cuts and a “political land grab” to transfer grant power from scientists to political appointees in US funding agencies.So far, the metascience agenda hasn’t been seized on by radical right parties in Europe. But Wilsdon worries it will cross the Atlantic, politicising research reform efforts and making them more difficult to carry out. The report is already making some in Europe sceptical of the entire idea. “The system is not without flaws, but the metascience discussion is not likely to improve the system but rather to generate munition to undermine it,” said Claes de Vreese, a professor of AI and society at the University of Amsterdam. Peter Thiel protégéOfficially, Science: A New Golden Age has just one named author: Michael Kratsios, the director of the Office of Science and Technology Policy and a former chief of staff to Silicon Valley mogul Peter Thiel. He also served as chief financial officer of Thiel’s Clarium Capital Management. Since the 1990s, Thiel has criticised US universities for moving away from teaching what he views as the classic works of western civilisation, and drifting towards “anti-Western zealotry.” And since 2011, he has offered two-year fellowships of $250,000 to young people to skip or drop out of university, and instead start companies or pursue scientific research. “College can be good for learning about what’s been done before, but it can also discourage you from doing something new,” according to the Thiel Fellowships website. In other areas, the Trump administration has promoted academics with a longstanding interest in metascience. For example, the head of the National Institutes of Health, Jay Bhattacharya, in 2020 co-authored a study arguing the funder backs overly conservative proposals, although he achieved wider prominence as a critic of pandemic lockdowns. Careless talk costs fundingEven before the Trump administration embraced the metascience agenda, some metascientists privately wondered whether they should be careful not to overstate dysfunctions in academia, in case this gets used as ammunition against universities. But others think being cautious with criticism is pointless. After all, last year, the Trump administration sought to cut funding from US universities on an entirely different premise: supposed antisemitism on campus. “I don't think these governments need a technical metascientific excuse to attack the universities, they will want to do so anyway,” said Will Stone, a researcher at Science Works, a new think tank advocating for a “metascience revolution” in the UK. “I think researchers should report what they find, even when the findings may be used to advance policies they disagree with,” echoed Russell Funk, a researcher at the University of Minnesota, who in 2023 co-authored a highly influential paper that argued scientific papers were becoming less disruptive over time. No justificationThat said, Funk thinks that metascientific research certainly doesn’t justify a weakening of universities. Instead, scientists need “time, resources and stability to pursue unfamiliar ideas,” he said. “Taking away those conditions works against the very goal the reforms are supposed to achieve.”The Institute for Progress, a Washington DC-based innovation policy think tank that has championed X-Labs and metascience units, also says that reforms should complement, not supplant, universities. “Unpredictable, unreliable, and reduced federal funding to researchers is destabilising to the very foundations of research and development and is bad,” said Jenn Gustetic, the institute’s director of metascience and R&D policy.Evolution or revolution?This points to a much bigger divide in the metascience community: how far and how fast should public R&D be shaken up? Does it need evolution or revolution? For example, Science: A New Golden Age says the science system relies too heavily on traditional “workhorse” project grants, the type that pay out around $250,000 a year to fund “hypothesis-driven science by small teams on tractable questions.” However, in criticising project grants, the report “decisively picks one side of a debate that is far from settled,” David Hilmer Rex, a metascientist based in Denmark, has written. In June, Pierre Azoulay, a metascientist at the Massachusetts Institute of Technology, defended project grants, saying that the alternative of X-Labs “merits scepticism.”A-B testingOne challenge in metascience is that it’s easier to generate evidence for some types of change than others. Most straightforwardly, research funders can run A-B tests on different ways of awarding money. For example, Germany’s Volkswagen Foundation recently trialled distributed peer review, where applicants rate each other’s proposals, and measured its results against traditional review panels. Distributed peer review made quicker decisions, although awarded money to largely different ideas. However, much of the focus of the metascience movement has been on founding fast-moving and free-acting new research organisations and funders, in contrast to the alleged stodginess of mainstream academia or public innovation grants. A culture of speed and freedom are the animating principles behind Germany’s Sprind or the UK’s Advanced Research and Invention Agency (Aria).Related articlesViewpoint: it's time to experiment with how Europe funds science European researchers sound the alarm that Trump rule changes will hit cooperationHowever, while it’s possible to closely study previously successful bodies, such as the US Defense Advanced Research Projects Agency (Darpa), for historical clues to their secret sauce, it’s impossible to guarantee in advance that the likes of Sprind or Aria will actually work as hoped. But advocates of new organisations say this inherent uncertainly shouldn’t stop us trying. “If we wait for definitive proof that something will work before we try it, I don't know where your proof is coming from,” said Stone. Trade-offsUp until now, experiments in metascience haven’t generally come with hard trade-offs over money. In the US, new ideas such as focused research organisations have often been funded by billionaire philanthropists. In Europe, new innovation agencies such as Sprind and Aria, or the Netherland’s new National Agency for Disruptive Innovation, haven’t needed explicit cuts elsewhere in the research system. But with the $1.5 billion establishment of X-Labs by the NSF, the trade-offs are becoming clearer. Some metascientists privately wonder whether a smaller pilot would have been more appropriate, given that the idea is untested. The Institute for Progress counters that the $1.5 billion X-Labs budget is spread out over a decade, so will account for less than 2% of the NSF’s annual budget. “It’s important to remember that [Darpa] was once an institutional experiment as well. Now it’s one of the most cited innovative funding models in the world,” said Gustetic.As for Europe?The US isn’t the only country placing metascience at the heart of its research strategy. Science: A New Golden Age looks admiringly at the UK, which in 2024 set up a Metascience Unit to scrutinise how it funds research. In Brussels, it’s more of a mixed picture. In 2018, the EU set up the European Innovation Council to funnel grants and equity to start-ups, although it’s sometimes criticised for awarding money too slowly. Recently, the council has started experimenting with challenges, where teams of inventors compete to overcome a technological challenge. The European Commission also wants to experiment with partially randomising grant winners, to cut down on bureaucracy. However, the Commission’s own advisers have said the EU’s own research schemes are too conventional. They want the Commission to establish a new dedicated unit to scrutinise and experiment with funding. But there’s no sign of a such unit emerging in Brussels’ plans for the next Horizon Europe programme, which from 2028 is set to distribute more than €160 billion over seven years. Sam Bogerd, director of breakthrough innovation at the Brussels-based Arq Foundation, an AI-focused think tank that also looks at metascience, says that Europe might have the opposite problem to the US: universities and basic research funding are still reasonably well supported, but there’s not enough experimentation. “We're not taking a close enough look at where this money can achieve the most, and I am worried that the good ideas around metascience will be tainted politically by their association with the Trump administration,” he said. He’s still lobbying for the Commission to set up an experimental unit. But in the meantime, the Arq Foundation plans to do its own research, and is currently hiring two metascience researchers to run the rule over how Brussels spends research funding.
EU science policy wonks debate prospect of stronger ties with Canada
Europe’s research and innovation sector has started asking questions on how European Commission President Ursula von der Leyen’s offer to make Canada “the first associate member of the EU” would actually work in practice, and who will get to shape priorities in a transatlantic relationship that is getting stronger. The Commission says it wants “a new model of association” under which the EU and Canada will aim to develop “a shared space” to face ongoing challenges. “Working in close coordination with our member states and the European Parliament, we will aim to create a new form of partnership that has not existed until now, building the closest imaginable form of association with a partner outside Europe,” a spokesperson told Science|Business.Locked in an escalating trade war with US President Donald Trump, who has repeatedly talked of annexing Canada, Prime Minister Mark Carney has been looking east, but full EU membership was never in play. Taking the floor a day after von der Leyen’s proposal, he agreed to strengthen ties under “an alliance of the future” but reined in enthusiasm on the new label. He also suggested expanding Canada’s involvement in the Erasmus+ student mobility scheme, to which it currently has limited access, and the next iteration of Horizon Europe. Canada joined the present Horizon Europe in 2024, but only contributes to collaborative projects.Neither side has detailed the next practical steps in developing this new relationship. “I think nobody at the moment truly knows how this will work,” said Michael Browne, chief executive and founder of Crowdhelix, a global collaborative network that connects players in research and innovation. “It’s more of a statement of intent for closer collaboration, which requires legislative frameworks and approval processes, which have not started.”Kurt Deketelaere, secretary general of the League of European Research Universities, said von der Leyen’s pitch to Canada is “politically significant, but the legal content still has to be negotiated and constructed.”Mattias Björnmalm, secretary general of the Cesaer university group, agreed that she had only opened “a political door” to Canada, as “associate membership does not come with a predefined set of rights in the EU institutions.”Not only does this status not currently exist as a legal category in the two treaties that set up how the EU functions, but the Commission president cannot unilaterally create a new category of EU membership.According to Deketelaere, Article 217 of the Treaty on the Functioning of the EU, which allows the bloc to make association deals with non-EU countries involving reciprocal rights and duties, is “the most obvious existing legal basis for building a much deeper EU-Canada relationship.”Getting universities involvedNo matter how this new cooperation takes shape, Liviu Matei, who heads the School of Education, Communication and Society at King’s College London, hopes to see universities involved in discussions from an early stage.“Its primary motivations, entirely justifiably, are political and geopolitical,” he said. “In the area of higher education, however, restricting the initiative to political and geopolitical considerations would limit the scope of cooperation and lead to distorted frameworks and counterproductive implementation.”It is all the more important since academic interests on the two sides of the Atlantic are “neither identical nor fully aligned,” Matei added. “This is not insurmountable; it simply requires work to articulate the details of this privileged cooperation, including its governance and funding frameworks, as well as its substantive content in education and research.”Related articlesCanada looks to deepen research and education links with the EUZaharieva hopes for a Horizon Europe deal in 2026Canada might participate in European Research Council schemes, for example, which was not on offer in the present Horizon Europe association agreement. But “there would have to be something in it for the EU,” Browne said. “They don’t want to be funding projects outside of the EU where intellectual property is going to sit outside of the EU. There has to be some kind of transfer of knowledge.”But access to funding will not by itself resolve all the practical difficulties of working together, said Björnmalm. “For researchers and students, these include visas and residence arrangements, recognition of qualifications and study periods, and the conditions for pursuing a research career across borders,” he said. “For universities, there is scope for more predictable access to shared laboratories, computing and research data, and stronger support for joint doctoral training and long-term institutional partnerships.”Linda Doyle, provost and president of Trinity College Dublin, said Europe should strive for the “closest possible expression” of this new political alliance. “If Europe is serious about recovering its voice and its place in the world, it needs to be strongly allied with countries who share its values and its vision for a stable, rules-based, peaceful world.”
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Calling all current and future scientists: Kiel is the place to be this week
This week, Kiel has become a meeting place for science in Europe. Researchers, school pupils, young scientists and members of the public are coming together through a series of major events led or co-organised by Kiel University.At the centre of it all are around 150 of Europe’s most talented young researchers, aged 14 to 20, who have travelled to Kiel from nearly 40 countries for the 37th European Union Contest for Young Scientists (EUCYS). Running from 22 to 27 September, the European Union’s flagship competition for young scientists brings together winners of national science competitions to present around 100 original research projects across fields ranging from engineering and computer science to medicine, environmental research and the social sciences. The winners will be announced at the Award Ceremony on Saturday.For Kiel University, hosting EUCYS is both an honour and a natural extension of a much longer story. Germany’s northernmost comprehensive university has invested for many years in supporting young scientific talent and bringing research into dialogue with society. The Kiel Science Factory gives school pupils opportunities to experience research first-hand, while programmes such as Rent-a-Scientist send researchers directly into local classrooms. Major annual public events including Kiel Week and the European Researchers’ Night take science beyond the campus through talks, exhibitions and hands-on activities.That long-standing commitment has increasingly taken on a European dimension – and this week, many of those efforts are coming together.One of the foundations for this success is the European Researchers’ Night (ERN), which celebrates its tenth edition in the Kiel region this year. The initiative is funded through the Marie Skłodowska-Curie Actions, with Kiel University developing the successful EU proposals and securing the funding, while regional partner KielRegion coordinates the many activities on the ground. Together with research institutions, schools, companies, local authorities and civil society, they have built ERN into a major platform for public engagement.Over the years, Kiel’s ERN programme has grown far beyond a single evening into a whole “Science Summer”, beginning with “Science Shopping” in spring and culminating tomorrow, 25 September, in Science Day.“We have developed a wide range of public engagement formats, often together with the other research institutions in the region, the city and regional authorities, schools, companies and civil society,” says Eckhard Quandt, Kiel University’s vice president for research, academic infrastructure and transfer. “Over the past decade, we have increasingly taken this commitment to the European level.”That combination of European funding expertise and strong regional partnerships also helped Kiel University take the next step. Drawing on its experience with ERN and its European networks, including the SEA-EU University Alliance, the university brought together Brest in France and Split in Croatia for a successful bid to the EU’s new Science Comes to Town initiative. Throughout 2026, the three cities are serving as Europe’s first Science Ambassadors, with more than one thousand activities bringing science into schools, public spaces, cultural venues and everyday life.EUCYS is perhaps the clearest example of how Kiel University is using Science Comes to Town to create new connections between major European initiatives. From the outset, the university deliberately planned the contest for the week of European Researchers’ Night and opened the EUCYS exhibition to the wider Science Day audience. Tomorrow, that means thousands of visitors can encounter the next generation of scientific talent first-hand, while the young researchers themselves gain a much bigger public stage.“Because we opened EUCYS up for European Researchers’ Night, there will be a lot of people actually visiting the exhibition,” says organiser Stefanie Altemark of Kiel University.“We wanted Europe’s most talented young scientists not only to compete with one another, but also to become visible to the wider public. At the same time, people in Kiel will have the opportunity to see what the next generation of scientists are already capable of,” says Quandt.“We’ve shown over the last years that science is a big part of Kiel, and it’s always been the goal to not only show that to people in Germany, but also to show it to people all over Europe. Thanks to Kiel University’s expertise in European funding programmes, we have been able to turn that ambition into reality,” says Sünje Fock, who is coordinating the Science Summer at KielRegion.The model is characteristic of Kiel University’s approach: combining European funding expertise and international networks with strong regional partnerships to give major initiatives greater reach and visibility.This year also marks the 30th anniversary of the Marie Skłodowska-Curie Actions, giving Kiel University the special opportunity to welcome Vanessa Debiais-Sainton, Head of Department for the Marie Skłodowska-Curie Actions at the European Research Executive Agency, to Kiel tomorrow. Her visit brings together two priorities that have shaped Kiel University’s work over the past decade: supporting researchers and bringing science closer to society. Debiais-Sainton emphasises how closely the two are connected: "For thirty years, the Marie Skłodowska-Curie Actions (MSCA) have given more than 150,000 researchers the chance to pursue their dreams and open up new fields. Doctoral Networks and Postdoctoral Fellowships give them the freedom to move, to connect, to train and to follow their curiosity across borders, sectors and disciplines. But excellence cannot live only in laboratories. Researchers’ Night takes science out of the lab and into the city, to the families, the schoolchildren and the curious minds who will become the next generation. Kiel shows what that looks like at its best. That is the MSCA promise: open science, open borders, open doors."For Kiel University, these activities are not separate endeavours. They are part of a broader understanding of academic excellence in which outstanding research, talent development, international cooperation, knowledge transfer and engagement with society strengthen one another.“For me, one of the most important lessons from the past decade is that scientific excellence, knowledge transfer, talent development and engagement with society cannot be treated as separate tasks,” stresses vice president Quandt. “They reinforce one another.”That philosophy is also reflected in Kiel University’s current bid for Germany’s Excellence University status. The designation is part of Germany’s national Excellence Strategy, which provides substantial long-term funding to selected universities to strengthen internationally competitive research and their overall institutional development. A successful outcome would provide new opportunities to build on what has already been created: deepening international cooperation, creating more opportunities for knowledge exchange and public engagement, and extending the university’s reach across the region and beyond. “If we are successful, it would allow us to take what we have built in Kiel considerably further – including expanding our networks and transfer activities beyond the region and increasingly across the Baltic area,” says Quandt.This week’s events offer a glimpse of what that could mean in practice: a university using its research strength, European expertise and regional partnerships to create opportunities for scientists at every stage of their careers while making science more visible, accessible and exciting to the wider public.
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Hands-on science can be cool
After spending many long days conducting experiments to find a new way to combat bacterial infections in crops, Misha Hegde and Mia Soleil Maurer have been rewarded with international recognition and access to top research facilities. But these are not typical scientists. They are 16-year-old German high school students.“Our supervisor told us that in order to start a project, you need to begin with either a question or a problem,” says Misha, adding that she and Mia had read about antibiotic resistance in certain plants being treated for bacterial infections. “We found out that antibiotics overuse is very common in agriculture,” explains Mia. “Our aim was to create an alternative to antibiotics and to try to raise awareness of the problem of overusing antibiotics.”Their subsequent research has focused on harnessing bacteriophages, the natural predators of bacteria, to eliminate pathogens threatening food crops treated with antibiotics. At the Schuldorf Bergstraße Jugend forscht MakerLab in Seeheim-Jugenheim, located in the German state of Hesse, they discovered a novel phage that infects the Rhizobium rhizogenes bacterium, which causes the hairy root disease that can reduce yields of tomatoes, carrots, soya beans and other food staples.The students believe their method could curb antibiotic use, while protecting plants from infections without disturbing the natural soil microbiome. “The application of phages is host-specific, so they would only kill the targeted pathogen or disease-causing bacteria,” explains Mia. It may also offer environmental benefits, since applying antibiotics can contaminate groundwater.Getting to this point has not been easy. The childhood friends admit to feeling frustrated when their trials did not yield the expected results. “We spent six months on our first experiment, just doing the same thing over and over and over again, to the point where we thought, is it even worth it? Why are we doing this?” Misha says. “You just need to be brave enough to take that first step and keep going.”The benefits of inquiry-based learningTheir determination has paid off. In 2025, the pair won first prize in biology at Jugend forscht, Germany’s national competition for young people interested in science, technology, engineering and mathematics. They were also among the winners of the German Research Foundation Europa-Preis, which is awarded to selected national winners at Jugend forscht, and took third place in the 2025 European Union Contest for Young Scientists.The Jugend forscht Foundation opens doors for young people to connect with scientists as well as industry professionals. Jessica Bönsch, executive director of the Foundation, sees Misha and Mia as prime examples of how young people can develop a deeper understanding of science through their own research projects. “The experience of working on your own research question is very important,” she explains, adding that “inquiry-based learning engages with real-life problems in a way that can be more motivating than traditional classroom teaching.”The Jugend forscht Foundation offers financial support through sponsor pools in Germany’s federal states. Some projects are developed in cooperation with student research centres, university labs or informal collaborative learning areas called makerspaces. Other activities start as hands-on “garage projects” and can grow within the Jugend forscht network and infrastructure.The Jugend forscht Foundation is also a partner of Science Comes to Town, an EU initiative to strengthen public awareness about science and create bridges between researchers and communities. The EU-financed project involves universities, research institutions and other stakeholders in three host cities — Brest (France), Kiel (Germany) and Split (Croatia).“It's so important for people not to live in a bubble, because I think science can be very scary if you misunderstand it,” Mia says of SCTT. The initiative’s aim of raising awareness about science is “absolutely amazing,” Misha adds. “I think it's the best way to kind of make science digestible for the public. In a world where misinformation in science is getting more radical, more dangerous, becoming more of a threat to the trust in scientific infrastructure and foundations, we need such programmes.”Misha and Mia also believe that SCTT can help break down gender stereotypes in science by encouraging young women to study and pursue careers in scientific fields. Both students have benefited from female mentors and encouragement they had when they were much younger. Mia’s love of science began with a class trip to a lab, while Misha — with a smile on her face — says she wanted to study history until “a teacher kind of coerced me into joining a school science club.”Recognition beyond EuropeIn May, Misha and Mia were among the finalists at the Regeneron International Science and Engineering Fair held in Phoenix, Arizona, and involving nearly 1,700 pre-university students from over 60 countries. “It was very crazy because there were so many people and so many teenagers interested in science,” Mia recalls. The event was also challenging. “It was eight hours of continuously presenting your project,” adds Misha.Attending the fair was a chance for the young women to see first-hand the value of international collaboration as well as how research cultures differ. “America is a bit more willing to take risks, and I think that's something we can learn about here in Europe,” Misha explains. However, she continues, “I think Europe has the talent, has the innovation and has the resources” to be competitive.Misha and Mia plan to continue their phage experiments in the new school year, inspired by the project’s hands-on nature and the support they receive from their supervisors. They have also attracted the interest of professional scientists and received invitations to leading research facilities, including the Centre for Synthetic Microbiology, jointly run by the University of Marburg and the Max Planck Institute for Terrestrial Microbiology in Germany. “It is so cool that we can do something to try to move the world in our school and at this age,” Mia says.After completing secondary school, Mia plans to study microbiology and pursue a career in medical research, focusing on Ebola and other infectious diseases. “This has been my dream for so long,” she says. Her friend Misha is interested in biological research with a focus on medicine. “I've gotten addicted to the process of going to the lab, planning out experiments, then failing, trying again,” Misha says. “I think there's just so much to be discovered, so much to be done.”The students' names and photos were published with the permission of their parents.Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
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