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More Than 400 Health Care Professionals to Gather in Illinois to Improve Patient Care
/PRNewswire/ -- The American Board of Medical Specialties (ABMS), the leading not-for-profit organization that oversees U.S. physician and medical specialist...
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Health Minute: September is Prostate Cancer Awareness Month
September is Prostate Cancer Awareness Month, and in the U.S. the number of new cases continues to increase with the steepest rise in advanced stages of the disease, according to the American Cancer Society. But early diagnosis significantly improves odds of survival. In today’s Health Minute, Mandy Gaither explains why screening is not “one size fits all” and what experts say every man should do when it comes to this cancer.
Las Vegas Arts District business improvement district proposal draws opposition
A proposal to create a “business improvement district,” or BID, in the Las Vegas Arts District is dividing property and business owners in the neighborhood.
Bucs $14M Addition Expected to Have ‘Prominent’ Role
One of the tougher fantasy football backfields to decide is the Tampa Bay Buccaneers. While many will be debating between Bucky Irving and Kenneth Gainwell as the top option in fantasy, Greg Auman of Fox Sports weighed in with a strong case for Gainwell. Auman noted that Zac Robinson has a chance to significantly improve […] The post Bucs $14M Addition Expected to Have ‘Prominent’ Role appeared first on HEAVY.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
NASCO and Doxim Partner to Modernize Health Plan Administration and Improve Communications
/PRNewswire/ -- NASCO, a leading provider of healthcare technology solutions, today announced a strategic partnership with Doxim®, a leader in customer...
NASCO and Doxim Partner to Modernize Health Plan Administration and Improve Communications
NASCO, a leading provider of healthcare technology solutions, today announced a strategic partnership with Doxim®, a leader in customer communications management (CCM) and engagement technology for highly regulated markets. The collaboration brings together NASCO's deep health plan administration expertise with Doxim's omnichannel communications capabilities to help health plans modernize operations and deliver more seamless, personalized experiences for all healthcare stakeholders.
Small Business Spotlight: Guitar shop aims to strike a chord
WHAT MADE YOU WANT TO OPEN STRING THEORY GUITARS INC.? ALLISON & LEE WILLIAMS: “We are lifelong musicians with a passion for playing. We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown area.” WHAT DOES YOUR BUSINESS PROVIDE, AND HOW DO YOU THINK IT HELPS CUSTOMERS? We love Wilmington and the live music scene here, and we wanted a way to be a part of the music community without having to start work at 9 p.m. We also want to be a destination for residents and musicians performing in and around the downtown areaTHE WILLIAMSES: “We’re a true basics-to-boutique destination. If you’re someone who’s just starting out, we can set you up with high-quality, brand-new equipment at a great entry-level price point. When you’re ready for your dream guitar, we can help you design and create a fully custom electric or acoustic guitar to your specifications. We have a broad selection of both guitars and amplifiers for players of every level. We also have a community board in the store to connect bands, students, instructors, repair technicians, and anyone providing a service to the local music community.” WHAT PAST EXPERIENCE DO YOU HAVE THAT LED YOU TO CREATE STRING THEORY GUITARS? THE WILLIAMSES: “Lee has played guitar for almost 40 years, from middle school band to gigging rock bands. Allison has a background in orchestra and musical theater, as well as retail management. We worked together as a husband-and-wife team in manufacturing for many years prior to moving to Wilmington. Having shopped in countless music stores over the years, we set up our shop with the goal of being welcoming and inviting. Our philosophy is ‘if it’s on display, it’s for play.’ No instrument or amplifier is out of reach in our store.” WHAT GOALS DO YOU HAVE FOR GROWTH? THE WILLIAMSES: “We would love to grow the bluegrass and folk instrument segment of our business. We carry banjos, mandolins, resonator guitars, ukuleles and related accessories. We’ve seen and heard plenty of talented bluegrass and folk musicians around Wilmington, and we look forward to expanding our selections to support this growing segment of the local music scene.” WHAT CHALLENGES ARE YOU FACING RIGHT NOW IN YOUR BUSINESS? THE WILLIAMSES: “Getting the word out about our brand and some of the unique brands we represent is a challenge for any new business. Online exposure through the Cargo District, Wilmington Downtown Inc. … and our online following is steadily growing. Our other challenge is the logistics of our streets. Our neighborhood is amazing, and you could spend the entire day walking around the Cargo District. As the District continues to grow, we’re seeing more pedestrian traffic, particularly in crossing 16th and 17th streets. We’ve seen some improvements in traffic calming, but the sooner we can improve safety with crosswalks and pedestrian signals, the more welcoming our neighborhood will be.”
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity
Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity
Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026
Kazakhstan records long-term gains in science as math scores fall in PISA 2025
The OECD’s newly released PISA 2025 results show that Kazakhstan achieved one of the largest estimated decade-long improvements in science among participating education systems, although math performance declined since 2022, Qazinform News Agency correspondent reports.
Mayoral candidates must improve public engagement; Prop 134’s flawed science (Letters)
Currently, there is little effort by the City of Boulder to bring opposing groups together to seek common ground. Public input is only solicited after a department has made a decision, so that “engagement” feels like a sales pitch. Boa…
The Market Forces Quietly Adding Thousands To Patient Bills
By Elisabeth Rosenthal and KFF Health News HealthDay ReportersWEDNESDAY, Sept. 9, 2026 (HealthDay News) — After a failed round of in vitro fertilization this year, Anne Hug’s fertility doctor said she had a single polyp in her uterus that should be removed to improve the chance of pregnancy. Hug, a ...
Can AI fix health care? In the chaos of emergency rooms, the technology comes up short
CEOs of the biggest AI companies have predicted the technology will “eliminate most cancer” and “improve treatment of most other ailments.” But nowhere better illustrates the challenge facing AI than an emergency department.
Parkinson demands more from Wrexham after draw
Manager Phil Parkinson acknowledges Wrexham have room for improvement after they were held to a 1-1 draw at home by Burnley.
Why does early treatment matter for psychotic episodes?
Early treatment for psychosis can improve recovery and challenge the idea that mental illness means a lifetime of suffering.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
Las Vegas Arts District launches petition to form business improvement district
A group of Las Vegas Arts District property owners have formally launched a petition effort to establish a Business Improvement District.
49ers defensive lineman Alfred Collins' injury latest blow to largely unproven unit
San Francisco 49ers second-year defensive lineman Alfred Collins tore his patellar tendon at the team's second practice in Melbourne and will be out for the season, coach Kyle Shanahan said.
Licensed counselor reveals link between weight loss and mental health effects
Bonnie Mitchell, a licensed professional clinical counselor in California, said that while a new study shows a correlation between weight-loss drug use and self-reported mental health symptoms, it cannot prove causation.
Iowa State volleyball swept by Iowa
Iowa State suffered a straight-sets loss to in-state rival Iowa on Tuesday night, falling 25-20, 25-21, 25-23. The Cyclones dropped to 4-2 on the season with the defeat, while the Hawkeyes improved to 4-2. Pam McCune, Mesaiya Bettis, and Nayeli Gonzalez paced the Iowa State attack with eight kills apiece. Alea Goolsby and Nayeli Ti’a […]
Mack Cleveland: Using computational materials science to engineer higher burnup fuels
Propelled by a love of mathematics and materials science, the MIT doctoral student models granular chemical reactions in uranium dioxide, work that might lead to less fissile nuclear waste and improved plant performance.
Pomona Cafe and Wine Bar Gets Green Light for Entertainment
Pomona Cafe and Wine Bar has received approval for an entertainment license. The Select Board unanimously approved Pomona’s entertainment license application as part of the consent agenda at Tuesday’s meeting....
Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston
It won’t be long now before the Boston Bruins gather for Training Camp in preparation for the 2026-27 NHL Season, and they’ll be out to prove that they’re better than losing in the opening round of the Stanley Cup Playoffs as they did earlier this spring.One of the key forwards for the Bruins is Casey […] The post Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston appeared first on HEAVY.
Council backs L.A. fast-food worker scheduling protections as businesses complain of tight margins
The Los Angeles City Council on Tuesday approved an ordinance to extend Fair Work Week scheduling rules to fast-food workers, adding predictable shifts and paid labor-rights training for tens of thous...
Is Davion Mitchell the Miami Heat's Biggest X-Factor?
Gabe Vincent highlights Davion Mitchell’s offensive impact, but Pelle Larsson could prove even more vital to the Miami Heat's championship aspirations.
‘Pitiful’ no more: Why business leaders say Madison County needs new $48M conference center
The Board of Supervisors approved issuing $48 million in bonds to fund the project at a meeting Tuesday morning.
From farm to table: Edgecombe County effort expands access to fresh, healthy food
An Edgecombe County farm is expanding its efforts to tackle food insecurity and improve access to healthy food across eastern North Carolina.
North Carolina MCO Alliance Health Taps Cortica to Rein in Autism Spending, Improve Outcomes
Ready to dive into what's shaping autism therapy-payer relations? Be a part of the Autism Investor Summit East this November 9–10. Get your tickets here.
Independent Kansas health systems launch shared services organization
Five Kansas health systems have launched a regional collaboration, called Astra Health, to pool resources and coordinate services while retaining their independence. | Astra Health's five founding members, who serve more than half a million patients annually, hope to improve quality and trim costs at scale while maintaining their independence.
Years before Nepal floods, scientists pitched a seismic warning system
The scientists, who are based in Europe, say the system could have triggered lifesaving alerts before floodwaters hit in Nepal. But the concept is unproven in the field.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
A-State sets fall enrollment record
Arkansas State University has set another fall enrollment record, reaching 18,775 students as continued growth among Arkansas freshmen, improved student retention, and rising graduate enrollment helped push the university past...
A-State sets fall enrollment record
Arkansas State University has set another fall enrollment record, reaching 18,775 students as continued growth among Arkansas freshmen, improved student retention, and rising graduate enrollment helped push the university past...
B2B Marketing Leaders Struggle to Prove Business Impact: 10Fold
10Fold research finds B2B leaders measure more than ever but struggle to connect metrics to revenue. See the communications ROI reset.
There is room for improvement in information-sharing about measles outbreak, officials say
Communication and information-sharing among agencies could be better with regard to Lancaster County’s measles outbreak, officials said during a recent Lancaster County Health Advisory Council meeting.
Business district battle in Back Bay Power Play
Back Bay's biggest landlord steps up its fight against a business improvement district for the neighborhood.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
Arsenal is watching back to back Champions League winner
Arsenal continue to eye top players who can improve their squad, and several names are on their radar, with Willian Pacho now emerging as one of the stars they want to sign. The Ecuadorian defender ha...
LMH Health, KU and others form Astra Health with goals of reducing costs, expanding access
LMH Health, the KU Health System and three other Kansas health systems have joined forces to form Astra Health, a collaboration aiming to improve care, reduce costs and better serve rural communities.
‘The View’ Hosts Miserably Fail Trivia About Their Experiences on the Show: ‘I Have No Idea What That Was’
The hosts of "The View" don't remember a whole lot of what they've done on the show over the years, and proved that on Tuesday
Jaguars’ Antonio Johnson could solidify elite secondary
The Jaguars’ defense was undoubtedly one of the NFL’s best last season, but it’s time to prove they can do it again.
New Cancer Care Technology at Intermountain Health St. Mary’s Improves Precision and Comfort for Western Colorado Patients
Intermountain Health St. Mary’s Regional Hospital has invested more than $2 million for new equipment and technology to improve quality of care and comfort of their patients receiving cancer care in the Grand Junction area.St. Mary’s Cancer Centers of Colorado purchased a new a new computed tomography (CT) scanner that offers several enhance...
AstraZeneca’s breast cancer pill gets approval from the FDA
AstraZeneca Plc’s breast cancer pill was approved by the U.S.
HHS Awards Over $225 Million to Improve Head Start Nutrition, Facilities and Services
The U.S. Department of Health and Human Services, through the Administration for Children and Families, announced over $225 million in Head Start supplemental awards.
Michigan Football Film Room: Fixing the Run Game
Michigan Football escaped Western Michigan, but serious offensive concerns remain. We break down the Wolverines’ run-game struggles and what must improve in this week’s film study:
Sony is reportedly preparing a big update for the PS5 and PS5 Pro with improvements to PSSR 2.0 upscaling
Sony is reportedly getting ready to release a major new system update for the PS5, with firmware version 14.0 currently is beta.
Miami Heat's Davion Mitchell Eyeing the Most Improved Player Award
A cryptic beach message signals high ambitions for the Miami Heat’s starting point guard. Surrounded by superstars, Davion Mitchell aims to leverage his facilitating role into a career-defining season.
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage
A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.
The Good, the Bad, the Ugly: Week 1
Through week one, we are already starting to have some clarity as to who the top teams in the Group of Six are. North Dakota State has looked dominant through two games, Boise State almost pulled off a massive upset against a National Championship contender, and the Air Force defense looks improved. It is certainly […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
NIH awards Penn State CTSI $28.2M to improve rural health
Penn State Clinical and Translational Science Institute (CTSI) at Penn State College of Medicine recently received a seven-year, $28.2 million grant from the National Institutes of Health.
When Peekskill’s Small Businesses Are Left Behind
Opinion > Peekskill Brewery's former owner says a $100,000 city grant proved worthless in trying to save the popular restaurant
LMH Health announces participation in Astra Health to expand access, improve care and reduce healthcare costs
We are pleased to announce that LMH Health is one of five independent Kansas health systems joining together to form Astra Health, a new regional healthcare collaboration designed to improve patient care, strengthen access to specialty services, and deliver more affordable healthcare options for employers and communities across Kansas. By working together, participating health systems […]
DeWitt’s Crossroads Business Park gets ready for growth
DEWITT, Iowa – Community leaders and development partners recently celebrated the groundbreaking of five regional water detention ponds in an expansion of the Crossroads Business Park, marking a major milestone in preparing the site for future industrial growth. The project is the first phase of infrastructure improvements that will make approximately 125 acres of development […]
Vertical Aerospace’s eVTOL Can Fly. The Passenger Business Is Still Unproven
Vertical Aerospace has made real flight progress, but five years of recapitalization show why passenger economics remain the harder test.
Getting Brown proved to be the move that unlocked …
Getting Brown proved to be the move that unlocked …
Florida State’s Third-Down Failures Prove Costly Against SMU
Florida State’s third-down failures proved costly against SMU, as execution issues on both sides helped turn opportunities into a 27-24 loss.
What Makes Guardant Health (GH) a Compelling Bet?
Artisan Partners, an investment management company, released its second-quarter 2026 investor letter for the “Artisan Mid Cap Fund”. The letter can be downloaded here. Global equities rebounded sharply in Q2 2026, recovering from March lows as resilient economic data, strong corporate earnings, and continued AI investment improved investor sentiment despite inflation concerns, delayed rate cuts, and […]
Yakima County's second large-scale solar facility is online
Roughly 3 1/2 years after his predecessor approved it, Washington Gov. Bob Ferguson was among 50 people celebrating in a remote corner of Yakima County as the Ostrea Solar project
Hawaii County panel approves $90M Keaau Health Center
A Hawaii County panel has cleared the way for Hilo Benioff Medical Center to build an outpatient medical clinic in Keaau.
NC’s Healthy Opportunities Pilot is coming back — but not at full strength
State lawmakers approved $25 million to restart the Medicaid pilot program after a yearlong pause, but some services may not return.
Korea freezes 2027 health insurance premium at 7.19%
The government has decided to freeze the national health insurance premium rate at 7.19 percent in 2027, citing stable finances and expected support from the government and premium revenue.The Ministry of Health and Welfare said that the Health Insurance Policy Deliberation Committee approved the 20
Israeli students plunge to historic lows in reading, math and science
International PISA results reveal the steepest decline in Israel's history across literacy fields, erasing 15 years of improvement. The troubling implication:
LABJ Stock Index: September 7
Cybercriminals Think You’re an Easy Target. Prove Them Wrong No one likes to manage dozens or even hundreds of ever-changing passwords. No surprise, then,
Galaxy S25 gets four new features with the new One UI 9 beta update
Today, Samsung released the second One UI 9.0 beta update for the Galaxy S25 series. Besides bug fixes and stability improvements, the update has brought four n
Vuskovic 'a massive talent'
Brighton goalkeeper Bart Verbruggen says Luka Vuskovic "is a massive talent" for his age and will "hopefully continue to improve" while at the club. Croatia defender Vuskovic signed from Tottenham in the summer for a club record £46m. "He is a big guy so he is a threat in the air and he can head the ball well," Verbruggen told BBC Radio Sussex.
Real Madrid vs Inter Milan, 2026 Champions League: Predicted lineups
Real Madrid host Inter Milan in the opening game of the Champions League’s Group Stage. Los Blancos are coming off a disappointing loss against Betis, so bouncing back tonight would improve the team’s confidence and momentum. Real Madrid predicted XI: Courtois; Dumfries, Konaté, Huijsen, Cucurella; Valverde, Bellingham; Brahim, Diomande, Vinicius; Mbappé. Inter Milan predicted XI: […]
Democratic Party-Led Resolution Restricts Lee Jin-sook
Democratic Party-Led Resolution Restricts Lee Jin-sook National Assembly Committee Approves Measure Amid Conflict-of-Interest Allegations
Arkansas regulators approve Blue Cross, Cambia Health affiliation
The Arkansas Insurance Department has approved a strategic affiliation between Arkansas Blue Cross and Blue Shield and Cambia Health Solutions. The affiliation will unify operations and enable the organizations to...
Japan upgrades Q2 GDP on slight capex improvement
By Satoshi Sugiyama TOKYO, Sept 8 (Reuters) - Japan's economy grew faster than initially estimated in the April-June quarter from the previous three months, supported by business spending that was
Georgia Southern football prepares for Clemson in week two
STATESBORO, GA (WJBF)- Week two of the college football season features one local matchup in Georgia Southern and Clemson. Both teams coming into the game with something to prove. The Eagles are coming off a 31-0 victory over Charleston Southern, making it their first shutout win at home since 2023. They’ll now face a bigger […]
Markel expands California workers' comp reach with Midwest General partnership
The deal launches days after California approved its second straight year of rising workers' comp benchmarks