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Trump’s Convention Offers an Unusual Fund-Raising Opportunity for Republicans
Republicans are hoping to use the Dallas extravaganza as a fund-raising opportunity, with some local parties charging as much as $20,000 to be an “honorary delegate.”
Edelman Financial Engines Expands Into Small Business
Edelman Financial Engines partnered with ADP to offer retirement plan advisory services to small and mid-sized businesses
60 Posts in 10 Hours: How Trump’s Social Media Reflects His Version of Reality
With an assist from A.I., President Trump offers a window into how he wants to be seen — and, critics say, a barometer of his mental state.
Launching a business school at Catholic high school in Victoria
It was an offer he couldn’t refuse, the culmination of his career. Scott Breimhorst couldn’t pass up the invitation to lead a new business school for Holy Family Catholic High School in Victoria. The 53-year-old father of three recognized an opportunity to bridge education and business, tapping into his vast network and cultivating the next generation of executives and entrepreneurs.
Apple shows off AirPods 5 with improved active noise cancellation
The AirPods 5 support better noise cancellation, Siri AI, and offer volume controls on the stem.
Edelman, ADP team up for small business retirement servicing
Edelman Financial Engines offers retirement plan solution geared at small and mid-sized businesses, partnering with ADP
Apple Announces Apple Watch Series 12 With S11 Chip, Upgraded Health Sensors and Ceramic Models
Apple today announced the Apple Watch Ultra 4, featuring a new S11 chip, a redesigned health sensing system, and a larger battery that Apple says delivers two days of battery life. With improved power efficiency, Ultra 4 offers up to 18 hours of workout tracking with full GPS and heart rate monitoring, or 45 hours in its maximum extended workout mode. It comes in Black and Natural titanium, alongside new band colors and a new titanium Hermès band.
Pritzker slams Trump — and his GOP midterm convention
Pritzker appeared in Dallas today to offer a Democratic counter-message.
Prisma Health to host free webinar on menopause
Prisma Health is offering a free webinar on Sept. 23 to help women better understand menopause, recognize common symptoms, and explore treatment options that can improve their quality of life.
Novig CEO Complies with NFL’s Market-Restricting Request
Novig won’t offer “easily manipulable, inherently objectionable, officiating-related, and knowable in advance” markets on NFL games.
Laredo College offers free small business incubator workshop
Laredo College is offering a free online small business incubator for people with a business idea they want to launch.
Why Lewis-Skelly remained at Arsenal despite strong outside interest
Myles Lewis-Skelly was linked with a move away from Arsenal this summer, with several teams willing to add him to their squads, including Chelsea and Manchester United.Both clubs had been offered the ...
Baptist Health Corbin encourages community to get flu shots, offers appointment-free vaccinations
Baptist Health is reminding people of the importance of an annual flu shot and of opportunities to get vaccinated.
Apple reportedly offering trade-in incentive to encourage iPhone upgrades
We’re expecting today’s shiny new iPhones to be accompanied by price raises, even if they aren’t as painful as initially...
Leaked Video Shows iPhone 18 Pro's 3-in-1 Dynamic Island in Action
A leaker has activated Apple's upcoming three-item Dynamic Island mode inside the iOS 27 simulator, offering the first video demonstration of the new iPhone 18 Pro feature. The leaker, known as pdfu, posted a video showing the Dynamic Island toggling between three simultaneous Live Activities, matching what Bloomberg's Mark Gurman described in his report earlier today. "The new Dynamic Island with 3 items is already supported in iOS 27," pdfu wrote.
H1 acquires Defacto Health to expand provider network intelligence
H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets. | H1 has acquired Defacto Health, a healthcare data company focused on provider network intelligence, in a move to expand its offerings for health plans and strengthen its healthcare data assets.
BBH Launches a New Technology Business, Braid, Solving for Intelligent Data Transformation
BOSTON, September 09, 2026--Brown Brothers Harriman (BBH) today announced the launch of a new technology affiliate, Braid LLC, focused on solving enterprise data transformation for financial services. Braid offers an AI-native data transformation platform that gives firms a scale solution to transform, connect, and manage their data with confidence.
GameSquare to acquire sports, music, and entertainment IP assets from FanEngine
Content provided by Seeking Alpha is intended for information purposes only, and that Seeking Alpha does not offer any personalist investment advice and is not a licensed securities dealer, broker, US investment adviser or investment bank.
Press Release: RCPH Offers Walk-In Immunization Clinics for School-Aged Children
Rowan County Public Health Offers Walk-In Immunization Clinics for School-Aged ChildrenFor Immediate ReleaseSalisbury, NC – Rowan County Public Health is offering two walk-in immunization clinics
Local Business Owners Start New Chapter with Opening of New PostalAnnex Location in Concord, California
Annex Brands, Inc., one of the leading franchisors in the packing, shipping and office services industries, is excited to announce the opening of its newest PostalAnnex location in Concord, CA to new owners, Rebeccah and Konstantin Rybalsky. This new PostalAnnex is set to offer a wide range of essential shipping and office services to the local community, making it easier to provide more service to more people in more places.
Accenture and Google Cloud establish Gemini Enterprise Business Group
The partnership aims to accelerate enterprise adoption of agentic AI, offering expanded industry expertise and technical resources.
Court To Table offers fun outlet through Trivia Tuesdays, bringing community together
Coming off a football high and returning to a week filled with studying and competing for parking can be a bit of a mood-killer for any LSU student. Court To Table, a local pickle ball themed entertainment venue and restaurant, likes to keep students occupied with Trivia Tuesdays. Beginning with a “Friends” themed trivia night...
Indigenous Arts Initiative will offer workshops on arts, entertainment industry
The Indigenous Arts Initiative, which includes partners from the University of Kansas, will bring two distinguished Indigenous artists and educators to Lawrence this September for a series of free public workshops exploring art, culture, storytelling and filmmaking.
AT&T Business and Amazon Leo form strategic partnership
AT&T Business and Amazon Leo have agreed to bring broadband services to AT&T Business customers nationwide, making AT&T is the first major U.S. telecom provider to offer converged connectivity solutions that include Amazon Leo’s low Earth orbit (LEO) satellite services. With the agreement, AT&T Business customers have multiple access connectivity options, which the company said […]
Mac Allister 'spoke brilliantly'
Former Chelsea and Everton winger Pat Nevin says Liverpool midfielder Alexis Mac Allister "said exactly the right things" when telling media that he is "very sad" not to have been offered a new deal by the club. The Argentine, who joined on a five-year contract from Brighton in June 2023, saw team-mates Dominik Szoboszlai and Ryan Gravenberch extend their Reds deals this year. "I often hear various players saying things and pushing things a certain way and you get a bit fed up with it," Nevin told BBC Radio 5 Live's Football Daily podcast.
Telemedicine company offers GLP-1s for addiction
A CDC Covid restructuring, public trust in Fauci, and more health news from Morning Rounds
920 Sports podcast: A look back at Week 3 in high school football
Ricardo Arguello and Mike Sherry offer analysis and commentary on Week 3 of the high school football season in the latest 920 Sports podcast.
Springfield Health Department partners with Big Y for free vaccine clinics
The Springfield Department of Health and Human Services and Big Y Pharmacy have partnered this season to offer vaccine clinics for community members.
Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan
Draymond Green's defense of Klay Thompson offers a useful blueprint for Miami Heat expectations. Thompson's role should center on shooting gravity, off-ball movement, and complementary offense-not recreating his 2017 Golden State Warriors production. Green's Ray Allen comparison reinforces that approach after Thompson's move to Miami. What Did Draymond Green Say About Klay Thompson and the […] The post Draymond Green's Klay Thompson Defense Reveals Miami Heat's Promising Plan appeared first on S
Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer
Baker Mayfield walked off the field in Jacksonville last month after a scoreless preseason finale, hardly the tune-up a quarterback wants heading into a contract year. Weeks earlier, the Tampa Bay Buccaneers passer had called the team’s opening offer ‘disrespectful’ and shut down extension talks completely. That standoff loomed over training camp all summer. Now, […] The post Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer appeared first on Gridiron Heroics.
Health-oriented Korean rice bowl restaurant opens on Whitney Avenue
BIBIM, a new venture from the owner of bb.q Chicken, aims to offer affordable, healthy Korean fare in a customizable form. In its opening week, the restaurant has sold 1,000 bowls, according to a manager.
Dignity Health to offer free flu vaccines throughout Kern County in September
BAKERSFIELD, Calif. (KGET) — As flu season approaches, Dignity Health’s Community Wellness Program will be providing free flu vaccines for Kern County residents. Dignity Health experts …
Vallejo’s Empress Theatre amps up entertainment offerings, dining
“The idea is simple: there should be something happening often enough that people throughout Vallejo, Solano County, and the greater Bay Area can make the Empress part of their regular week,” says the Empress Threatre.
Free classes offer first aid skills for mental health
Astra Mental Health and Recovery has free community Mental Health First Aid classes coming up Sep. 10 and Sept. 23.
Free classes offer first aid skills for mental health
Astra Mental Health and Recovery has free community Mental Health First Aid classes coming up Sep. 10 and Sept. 23.
Starbucks raises health insurance premiums, sparking worker tension
Rising costs for health insurance premiums offered to Starbucks workers are sparking tension.
Louisville opens first mental health crisis center
Louisville’s first mental health crisis center is now open, offering walk-in help and a new option beyond jail or the emergency room.
Richarlison Accepts Vasco Offer but Tottenham Loan Limit Blocks Move
Richarlison has reportedly agreed to join Campeonato Brasileiro Série A side Vasco da Gama, but the move can’t proceed because Tottenham Hotspur have already reached their limit for international loans.
AT&T Business Expands Work with Amazon Leo for Resilient Connectivity
AT&T Business has furthered its agreement with Amazon’s Amazon Leo constellation to offer “converged connectivity solutions” integrating satellite
Nick Offerman Responds to Ben Shapiro’s Homophobic ‘Last of Us’ Digs
The actor hadn’t watched the conservative host’s temper tantrum over his Last of Us episode until now.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Is the news stressing you out? MS NOW partners with Calm
MS NOW wants to offer news viewers a break when they feel overwhelmed. The Versant-owned progressive-leaning news outlet announced Tuesday that it has entered a partnership with Calm, the San
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Harvard, MIT scholars head north as Carney offers millions
Canada is investing $362 million to lure 64 top global scholars, including dozens from Harvard, MIT and other elite U.S. universities, to advance research in health and artificial intelligence.
Ink Business Unlimited vs. Spark Cash Select: Which is best?
The Ink Business Unlimited and Spark Cash Select both earn 1.5% cash back with no annual fee. But the Ink Business Unlimited is better for most businesses.
AMP Sports Launches The Dark Side Podcast with Seattle Seahawks Super Bowl Champions Derick Hall and Byron Murphy II
SEATTLE – September 8, 2026 –Sinclair’s AMP Sports today announced the launch of The Dark Side, a new podcast featuring Seattle Seahawks Super Bowl champions Derick Hall and Byron Murphy II, alongside KOMO News Sports Director Niko Tamurian. Each week, The Dark Side will go beyond traditional game analysis, with Hall and Murphy offering a...
Baptist Health Paducah to offer 'Monday Night Mammograms' during Breast Cancer Awareness Month
Baptist Health Paducah will recognize Breast Cancer Awareness Month by providing Monday Night Mammograms throughout the month of October.
New Cancer Care Technology at Intermountain Health St. Mary’s Improves Precision and Comfort for Western Colorado Patients
Intermountain Health St. Mary’s Regional Hospital has invested more than $2 million for new equipment and technology to improve quality of care and comfort of their patients receiving cancer care in the Grand Junction area.St. Mary’s Cancer Centers of Colorado purchased a new a new computed tomography (CT) scanner that offers several enhance...
‘Antiques Roadshow’ appraisers coming to Fort Plain Museum
Leigh Keno and Joel Bohy of PBS’ “Antiques Roadshow” will offer appraisals during an Oct. 10 antiques show at the Fort Plain Museum.
Braves September call-up offers 'experience' off bench before postseason
This could be a sneaky good call-up for the Braves.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Community Partners Offer Reduced-Cost Rabies Clinic
Regional clinics are setup to support animal health ensuring pets remain protective.
Texas Sunset Review offers chance to address the mental health crisis-to-prison pipeline
Updates in policy for people with developmental disabilities and serious mental illness could reduce repeated cycling through the carceral system, advocates say
Nearly half of depression risk factors overlap with physical illnesses, especially gut disease
QIMR Berghofer researchers have identified a strong genetic link between gut-related health conditions and depression in a study offering new insights into why physical illnesses often accompany the mental ...
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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