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Catawba College Dr. Michael Bitzer on shifting political attitudes and America's 250th anniversary
New polling is out on where North Carolinians stand on President Trump, the state’s U.S. Senate race, and the nation’s 250th birthday. We’ll explore the details with Catawba College political scientist and pollster, Michael Bitzer
‘They had hyped us up so much’: Seattle businesses near World Cup stadium report declining sales
The city’s tourism board estimated 750,000 visitors would visit over the course of the World Cup
Healthcare That Comes to You: Inside Iredell County's Mobile Health Unit
Discover how Iredell County's Mobile Health Unit is bringing affordable, preventive healthcare directly to neighborhoods, workplaces, churches, and community events. Learn about the services offered and how this clinic on wheels is improving access to care across the community in the latest episode of Front & Center.
IFT: Proposed US federal grant rules threaten nutrition science funding & competitiveness
The US Office of Management and Budget (OMB) recently proposed rules to rewrite the Uniform Guidance — the rulebook for all federal grants. Institute of Food Technologists (IFT) chief science and technology officer tells Nutrition Insight that these rules are set to undermine the nation’s scientific research for food and nutrition and hinder global competitiveness.
Oscar Health's Mark Bertolini on making 'healthcare work for all'
A former CEO of Aetna and Bridgewater (and current chairman of the board of Verizon) brings his leadership philosophy to a challenger brand.
There Are Many Things That Could Increase the Birth Rate. This Major One Is Usually Ignored.
Conservatives tend to blame women for declining fertility. They’re wrong.
Pittsburgh teens with disabilities help shape more accessible healthcare
During a mock appointment to a UPMC adolescent health clinic, a group of Pittsburgh teens stood in as patients. They were actually there as accessibility experts as they are also people living with disabilities.
CMS seeks to cut $260M in imaging spending through ‘site-neutral’ reforms
The agency said it hopes to control “unnecessary” increases in the volume of clinic visit services furnished at certain off-campus hospital departments.
4 Health Benefits of Sardines
Sardines are great sources of nutrients like protein and omega-3s. But before you toss a few down, learn about their potential downsides, too.
Famitsu's most wanted games - July 5, 2026 - Xenoblade Genesis makes first appearance, Zelda moves up
It’s time for the latest Famitsu’s most wanted games chart outlining what Japanese gamers are looking forward to based on reader votes. This is a pretty interesting week as more titles are starting to pop up from the summer showcases. As part of that, Xenoblade Genesis lands on the chart for the first time. Zelda: Ocarina of Time also just...
On the California Coast, a Picture-Perfect City Falls on Hard Times
Santa Monica is starting to bounce back from a state of “fiscal distress” including financial woes, declining international tourism and fading retail.
Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications
Signal Transduction and Targeted Therapy - Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications
FIFA World Cup referee also runs insurance advisory business
Serious offence allegations against match officials are rising globally, underlining why referee cover exists
Chris Stapleton and Chaka Khan celebrate America's 250th at the L.A. Coliseum
Chris Stapleton was the headlining act at a Fourth of July benefit concert that also featured Smashing Pumpkins, Chaka Khan, Maren Morris and Queen Latifah.
It’s not clear how California’s education power shift will impact schools this year
After California lawmakers and the governor changed state law so the Department of Education is overseen by the governor instead of the state superintendent, it’s unclear how the move will impact the upcoming school year. "What we hope to see is a streamlining of the administration of public education in California," Assembly Education Chairwoman Assemblymember Darshana Patel, D-San Diego, said in an interview on California Politics 360.Patel helped carry the change through legislation at the state Capitol.
AI in Mental Health: Why Clinicians Need to Be in the Room
As clinicians, we learn not to be agreeable, we learn to challenge and sit in discomfort. We ask the hard questions underneath the one being asked. That is the work these tools are not yet built to do.
Months after Mayo Clinic left, some rural towns adjust to a ‘completely different health continuum’
With impending federal changes to Medicaid, workforce issues and the increasing cost of American healthcare, many rural healthcare providers are in a period of uncertainty.
Conservatives rage over re-funding of Planned Parenthood
Despite the restoration of Medicaid funding for health care services -- but not abortions -- dozens of closed clinics are not likely to reopen.
Karpa Health Launches Turnkey Nationwide Telehealth Platform as GLP-1, Peptide, and Hormone Demand Accelerates
The all-in-one platform helps entrepreneurs, clinics, med spas, gyms, and wellness brands launch cash-pay telehealth programs nationwide. TAMPA, FL / ACCESS Newswire / July 3, 2026 / Karpa Health today announced the general availability of its turnkey ...
Celtics' Jayson Tatum was reportedly the final straw to cutting ties with 76ers' Jaylen Brown
The Celtics traded Jaylen Brown in a move that felt like was due to the declining relationship with the organization. However, it seems that Jayson Tatum was a big reason as well.
Anthropic Wants to Make Its Own Drugs With Help from Claude
The AI company is launching preclinical drug programs for overlooked diseases.
"We are profoundly disappointed by Sony's decision" – Game companies express dismay at the end of PlayStation disc production
Atari, Iam8bit, Lost in Cult, and Silver Linings Interactive are among the firms lamenting the loss of physical games
South Carolinians can support lifesaving global health work and demand accountability
Chad Connelly, founder of Faith Wins, writes about the lifesaving work since 2023 of a federal AIDS relief program and how he thinks Congress can save it.
Trump got the Senate candidates he wanted. How much will he spend to help them?
President Donald Trump has reshaped the U.S. Senate map by sidelining some Republican incumbents and promoting loyalists
Western Wisconsin health clinic in lockdown amid 'active situation'
A health clinic in western Wisconsin is in lockdown Thursday afternoon as law enforcement responds to an "active situation."
Legacy Business Spotlight: Baton Rouge Clinic
— ESTABLISHED 1946— The Baton Rouge Clinic, AMC has been delivering patient-centered care to the Capital Region for 80 years. Founded by four local physicians, the clinic has grown from a single practice into a network of 18 locations serving nearly 400,000 patients across Louisiana, while remaining true to the physician-led model thathas defined it […]
Why you should wash new clothes before wearing; signs that you are aging well; effective leadership in health care; plus other stories with Vanderbilt Health sources
Jami Miller, MD, Professor of Clinical Dermatology, and David Gaston, MD, PhD, Assistant Professor of Pathology, Microbiology and Immunology, are quoted in a Southern Living piece about the importance of washing new clothes before wearing them. Dyes, chemicals, mold and bacteria are all potential troublemakers lurking around your new duds. Parul Goyal, MBBS, Associate Professor of Clinical Medicine, was quoted in a Huff Post story outlining signs that you are aging well. Tae Kon Kim, MD, PhD, Assistant Professor of Medicine, was interviewed by Healio for a story headlined, “Effective leadership in health care ‘starts with listening.’” AAMC News reporter Patrick Boyle interviewed Wes Ely, MD, Professor of Medicine and Critical Care, for a story about ICU delirium. PharmaVoice reporter Kelly Bilodeau interviewed Romney Humphries, PhD, Vice Chair and Executive Medical Director, Clinical Services, for a story about the CDC’s new data that shows an alarming increase in the prevalence of a gene that can make “nightmare bacteria” significantly harder to treat. American Community Media interviewed William Schaffner, MD, Professor of Preventive Medicine, for a piece about Ebola that was reused by several media outlets around the U.S., including The Mississippi Link. Stacie Dusetzina, PhD, Professor of Health Policy, was quoted by The Independent in a story about how Medicare will soon cover weight-loss drugs. Courtney Schadt, MD, Associate Professor of Dermatology, was interviewed by Tennessean reporter Beth Warren, about tanning safety and tanning fads circulating social media. WKRN News 2 interviewed Amanda Peltier, MD, Professor of Neurology, about the correlation between head trauma and ALS following the diagnosis of former Titans running back Chris Johnson.
New mobile health clinic launches in Boyle Heights for residents affected by warehouse fire
A new mobile health clinic has launched in Boyle Heights to provide medical services to residents affected by the warehouse fire, as some community members continue to report health concerns tied to the incident.
Seattle hospital cuts family medicine resident slots
Fewer residency slots in family medicine could add to a troubling shortage of doctors in Washington, especially among community clinics.
How remote patient monitoring advances affordable healthcare
As global medical costs face double-digit spikes, remote care is a clinical tool and an economic necessity.
Patient enrolment begins in a scientific trial to identify the first effective treatments for Bundibugyo virus disease
In a major international effort to evaluate potential treatments for Ebola disease due to Bundibugyo virus (BVD), the PARTNERS clinical trial has opened enrolment today for patients in the Democratic Republic of the Congo.
The Business Model of Colleges Is Broken. It’s About to Get Worse
Declining enrollment and Trump’s policies are “breaking the business model that built the modern higher education system,” writes Jeffrey Selingo.
Summer travel health: tips for heat exhaustion, insect bites and travel vaccines
Stay healthy while traveling with help from CVS Pharmacy and MinuteClinic. Get vaccines, refill prescriptions and prepare for summer travel risks.
Trinity Health Grand Rapids works to offer more free medication
Trinity Health Grand Rapids is rolling out a new program that aims to get prescription medicine to some of the lowest-income patients in West Michigan.
Cape Fear Valley Health cuts nearly 200 positions
Cape Fear Valley Health is eliminating approximately 200 positions as it faces declining federal reimbursements and rising healthcare costs.
Booze schmooze: The alcohol industry, frazzled by headwinds, wields its power behind the scenes
Demand for alcohol is declining. The industry is fighting harder and more creatively than ever against limits — and winning.
Bethesda Health Clinic reaches $25M fundraising goal for new Tyler facility
Clinic says new 61,000-square-foot building will serve 50% more uninsured patients starting spring 2027
Children’s Hospital Los Angeles’ 2026 TSRI Science Day Highlights Advances in Cancer Biology
June 17 saw more than 400 scientists, clinicians, research staff, and other Children’s Hospital Los Angeles team members come together for The Saban Research Institute’s (TSRI) yearly symposium and poster session—Science Day 2026.
Multnomah County Just Fired a Key Health Leader. He Says He’s a Scapegoat in a Power Struggle.
Anirudh Padmala’s departure marks worsening tumult in the top leadership overseeing the network of 19 federally-funded Portland area clinics, which collectively serve tens of thousands patients annually.
FMOL Health pegs Cancer Institute investment at $70M, shares timeline
FMOL Health expects to invest roughly $70 million to transform the former Bone & Joint Clinic of Baton Rouge building into a new home for the Our Lady of the Lake Cancer Institute, according to E.… Already an INSIDER? Sign in. Already an INSIDER? Sign in
N.I.H. Announces World’s Largest Integrated Health Database
It contains more than half a million people’s genomes, paired with clinical records and wearable tech data. That gives researchers unmatched power to study both diseases and treatments.
U.S. Army Contracting Command personnel recognized for streamlining small business procurement
At the FY25 Department of War and Department of the Army Small Business Awards, Army Contracting Command (ACC) was honored for strategic acquisition reforms that diversified and strengthened the defense industrial base.
DR Congo health workers battle Ebola despite scant protection
In Ituri, DR Congo's Ebola epicenter, overwhelmed clinics and a lack of protective gear leave health workers exposed as the outbreak spreads beyond control.
Scientists say creatine may help fight depression
Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply. A new review examined five randomized clinical trials involving 238 participants and found mixed results. Two studies, both involving women with major depressive disorder, reported that adding creatine to standard treatment improved symptoms, while three others found no meaningful benefit.
SGMC Health Welcomes 32 Resident Physicians
SGMC Health welcomes its newest cohort of resident physicians as they begin their clinical training, representing a significant milestone in the continued advancement of the organization’s Graduate Medical Education (GME) program.
Kristen Hogan joins Essentia Health-32nd Avenue Clinic to practice nephrology
The Essentia Health-32nd Avenue Clinic is excited to welcome Kristen Hogan, an advanced practice registered nurse and certified nurse practitioner in nephrology.
Catholic Charities unveils behavioral health center
BUFFALO, N.Y. (WIVB) — Catholic Charities unveiled its behavioral health center on Monday with more amenities to serve the surrounding community. The work on the clinic, located on Rich Stree…
How 'masculinism' is reshaping American politics
Can the new faultline in American political tribalism be broken down along the masculine question? Republican attacks against Texas Democratic Candidate for Senate James Talarcio falsely claim he's vegan as a challenge to his masculinity. While others in the GOP say they want to repeal the Woman's right to vote. What is he overarching strategy here. Why testosterone matters in today's politics.
FDA approves surgical device for high-risk aortic procedures
The AMDS Hybrid Prosthesis was designed to help clinicians treat DeBakey Type 1 dissections complicated by malperfusion. It works as a complement to hemiarch replacement, preserving the native arch and making reinterventions possible if needed.
'They’re like my sisters now': Boutique comforts women post-surgery
While hospitals can feel very clinical, there's a shop that offers products for women post-surgery with kind, friendly faces to provide support.
Essentia Health-Cloquet Clinic welcomes Jaycee Hewitt to practice family medicine
Jaycee Hewitt, an advanced practice registered nurse and certified nurse practitioner in family medicine, is thrilled to join the Essentia Health-Cloquet Clinic.
Essentia Health-Duluth Clinic welcomes psychotherapist Jeremy Perrett
Jeremy Perrett, a licensed independent clinical social worker specializing in psychotherapy, is thrilled to join the Essentia Health-Duluth Clinic.
Healthcare AI's next big leap: Removing friction from clinical workflows
Rather than just adding more applications, one CMIO says, organizations should focus on using automation and intelligence to eliminate unnecessary steps, reduce clinician burden and streamline care delivery.
Cleveland Clinic Tackles Hunger, Housing and Maternal Health
In 2025, our teams continued to address critical social drivers of health, expand access to care and resources, and build stronger, healthier communities.
Mayo Clinic Q&A: Watch out for summer sports injuries in youth and adult athletes
DEAR MAYO CLINIC: Our teenagers are both student athletes and active in their sports year-round. I'm concerned about injuries that could sideline them. What should we watch for? ANSWER: As the school year ends, summer sports heat up for students and adults alike. Summer may be a prime season for a sport, such as baseball […]
The Ken-ification of Hungarian Politics
June 29, 2026 | What does Orbán’s defeat reveal about the limits of performative masculinity in populist politics?
Ingredion plans global Benicaros prebiotic expansion across gut and immune health applications
Ingredion highlights that its recent acquisition of the Benicaros prebiotic is a strong strategic addition to its Healthful Solutions portfolio, supporting the company’s formulation versatility alongside expansion of health-forward and clean label ingredients. The company purchased the patented prebiotic fiber, made from upcycled carrot pomace, from NutriLeads earlier this month. With the deal, Ingredion obtained full ownership of all intellectual property, trademarks, human clinical trials, and know-how related to manufacturing Benicaros.
Benchmark Scores Don’t Break. Clinical Reality Does. The Health AI Readiness Illusion.
Nature Medicine's frontier AI evaluation exposes a dangerous gap: models acing medical benchmarks collapse under adversarial pressure, and the FDA has no…
These Michigan businesses are finding a silver lining with tariffs
Resale and salvage retailers are taking advantage of a circular, domestic supply chain as shoppers shift to bargain-hunting and buying local.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Sanford Health to highlight best practices for AI adoption at national leadership conference
Sanford Health’s Dr. David Newman will speak at two HIMSS AI conferences in Boston this week, discussing AI adoption, governance and clinical workflows.
Sanford Health to highlight best practices for AI adoption at national leadership conference
Sanford Health’s Dr. David Newman will speak at two HIMSS AI conferences in Boston this week, discussing AI adoption, governance and clinical workflows.
Trump’s Great American State Fair attendees say they haven’t noticed politics overshadowing the celebration
President Donald Trump kicked off the event with a headlining speech Wednesday after musical acts dropped out of the lineup citing concerns over partisanship.
He’s no longer allergic to the sun, thanks to a clinical trial. Meet Louisiana's ‘vampire guy.’
“I was missing a lot,” Pierre Mouledoux said. “But I'm not missing out anymore.”
Government overreach won’t fix youth gender medicine
The real cure for bad science is better clinical trials, not lawsuits.
Government overreach won’t fix youth gender medicine
The real cure for bad science is better clinical trials, not lawsuits.
Despite Mayor Brandon Johnson campaign promise, 911 mental health response team flounders
Throughout his 2023 mayoral campaign, Brandon Johnson championed a progressive vision of sending teams of mental health clinicians instead of police officers to help people suffering from psychiatric emergencies. But since he took office…
Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
Free health clinic aims to expand care access on city's West Side
Free preventive care is coming to San Antonio’s West Side Saturday. The Health Collaborative’s Neighborhood Clinic offers 3D mammograms, screenings, vaccines, dental checks, food and help connecting to ongoing care.
The sky is not falling. Americans are getting healthier.
Despite declining obesity and heart disease rates, increasing cancer survival rates, and a record high life expectancy, politicians from both parties are pushing costly and ineffective policies to …
Is 10,000 Steps a Day Actually Based on Science? Here's What the Research Says
The 10,000 steps target came from a 1960s Japanese marketing campaign, not clinical research. Here's what the evidence actually supports about daily step counts, mortality risk, and what a realistic goal looks like for most people.
Your health insurer shouldn’t decide your treatment plan. That’s what your doctor (and possibly AI) should be doing.
With a digital health record, clinicians and AI-driven diagnostic tools would be able to see your full health history — and then make better decisions.
Baylor teen health clinics provide free medical care, mental health services
According to the latest U.S. Census data, Texas leads the nation in the number of uninsured residents.
$13 million in federal funding to be distributed across West Michigan clinics
More than $13 million in federal funding will be distributed across West Michigan hospital and clinic systems for research projects and healthcare infrastructure.
Moderna highlights expanding mRNA platform at Science Day
Moderna's Horizon programme contains a variety of mRNA assets in varying stages of development, including a preclinical in vivo candidate.
Most Patients Want Docs To Break Cancer News Directly, Not Through Portal Messaging
By Dennis Thompson HealthDay ReporterFRIDAY, June 25, 2026 (HealthDay News) — People are becoming more comfortable communicating with their doctor through clinics’ patient portals. Folks use the portals to ask their doc questions and even to review the results of recent medical tests. But there are ...
Ben Wood, longtime three-dot columnist known as ‘Mr. Show Business,’ dies at 94
Ben Wood, a multifaceted copy editor, food and entertainment writer, and three-dot columnist for the Honolulu Star-Bulletin and Honolulu Star-Advertiser for almost 50 years, died June 19 after several years of declining health. He was 94.
Freedom Con: Thousands of Men Gather for Christianity and Feats of Strength
Thousands of men and boys gathered in central Washington for masculinity, Christianity and right-wing politics.
Clinicians are making more money despite stagnant reimbursement. Guess how?
Compensation for healthcare providers rose some 4.3% in 2025. The sobering news is that the gain owes more to heavier daily workloads than to bigger per-patient billings.
Baxter Health Heart and Vascular Clinic Welcomes Brandi Watson, APRN
Baxter Health is proud to welcome Brandi Watson, APRN, to the Baxter Health Heart and Vascular Clinic. Watson joined the team on May 15 and is currently accepting new patients. Watson brings more than 25 years of experience caring for some of the most critically ill patients. Much of her career has been spent in intensive care settings, where she learned to make fast, high-stakes decisions for patients whose lives depended on getting the right care at the right moment. That kind of experience, which is gained through years at the bedside, is exactly what heart and vascular patients need from a provider.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Two NC lawmakers, a Democrat and a Republican, push Congress to delay SNAP changes
Above the federal penalty threshold, NC could owe $140M a year, putting at risk a program that helps over 1.2 million North Carolinians.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
GLP-1 and reduced cancer risk discovery earns UT Health San Antonio fellow prestigious Helio NextGen Disruptor Award
Colton Frisco Jones, MD, a 2nd-year fellow at the Mays Cancer Center at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), recently earned the prestigious Healio NextGen Disruptor Award at the American Society of Clinical Oncology (ASCO) 2026 annual meeting in Chicago.
First-of-its-kind discovery earns UT Health San Antonio Mays Cancer Center fellow prestigious Helio NextGen Disruptor Award
Colton Frisco Jones, MD, a 2nd-year fellow at the Mays Cancer Center at UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), recently earned the prestigious Healio NextGen Disruptor Award at the American Society of Clinical Oncology (ASCO) 2026 annual meeting in Chicago.
Hackensack Meridian Health Graduates Largest Number of Residents and Fellows Yet for Network
314 doctors continue their quest to be the best clinicians possible within New Jersey’s largest and most comprehensive health network
Supporters of KY’s Lee Specialty Clinic supporters want politics put aside to avert cuts
Over 100 people rallied in support of Lee Specialty Clinic in Frankfort Wednesday afternoon and testified on the importance of its services.
Union issues spark conflict between Group Health Co-op and members
Changes in the Group Health bylaws have become a point of contention for members who say they are ignored by the co-op's management,
UNM Project ECHO Works Closely with World Health Organization on Disease Outbreaks
When a major disease outbreak occurs, the World Health Organization (WHO) calls on Project ECHO at The University of New Mexico Health Sciences Center to help support the transmission of accurate, timely health information to clinical health workers and...
New study reveals gaps in how mental health is measured in European Region
A new WHO/Europe study found wide variation in how research measures mental health in the WHO European Region, underlining the urgent need for standard monitoring.
Pa. measles cases jump, spread to Northumberland County
An unprecedented measles outbreak in the state has spread to an additional county, the Pennsylvania Department of Health announced Wednesday. Health officials...
Noblesville store attributes closure to declining business caused by road construction
NOBLESVILLE, Ind. — A consignment store in downtown Noblesville has indicated that its doors are closing due to the impacts of road construction. At the corner of Ninth and Logan Streets, Velvet Pl…
Mercy Helps Position St. Louis as Global Gateway for Healthcare Innovation
Mercy continues to bring innovative thought leadership to the communities it serves and beyond. Dr. Damon Broyles, Mercy vice president of clinical innovation, informatics and precision medicine, recently shared insights and helped attract new companies to St. Louis’ nationally recognized healthcare industry as part of BioSTL.
The Trump administration has attacked science 574 times. Track each instance with this online tool
The Union of Concerned Scientists is aiming to visualize the scale of the president's anti-science actions, from censorship to the sidelining of experts.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
SouthCoast offering sports physical clinic
Physicals required for all student-athletes in Georgia
NYC Health + Hospitals Launches Application for Clinical Leadership Fellowship 2027-2028
NYC Health + Hospitals today announced the opening of applications for the Clinical Leadership Fellowship, a one-year program to develop the next
Galaxy Z Fold 8 wallpapers leak, and I hope the phone’s colors look half as good
A new leak has revealed the alleged wallpapers Samsung is bringing to the Galaxy Z Fold 8, with everything lining...
This startup is using AI to close gaps in women’s healthcare
Xella Health’s precision health platform combines biomarker testing, clinical guidance, and AI analysis to help women get earlier answers about hard-to-diagnose conditions.