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These Good Health snacks pass the lunchbox test (and taste good too!)

Looking for healthier snacks for you and your kiddos? Good Health has a guilt-free lineup of veggie straws, chips and more.

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Apr 2 • 1:07 PM EDT • Health • usatoday.com
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Rising youth sports costs in Hampton Roads: How families can keep kids in the game
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Apr 2 • 12:00 PM EDT • Sports • 13newsnow.com
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Panoramic Health and West Coast Kidney Institute Launch Concord Cardio-Renal Research Institute to Advance Clinical Trials in Cardio-Renal-Metabolic Disease

/PRNewswire/ -- Panoramic Science, the clinical research division of Panoramic Health, and West Coast Kidney Institute today announced the launch of the...

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Apr 2 • 8:45 AM EDT • Health • prnewswire.com
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Families reeling from Baystate Health decision to end gender care for youth

Baystate Health, the largest health center in western Massachusetts, announced in February it would stop gender-affirming treatment for children, offering only counseling. This came after the Trump administration threatened to strip Medicaid and Medicare funding from any hospital providing the care to kids.

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Apr 2 • 8:13 AM EDT • Health • wbur.org
UAB launches Moms and Kids Mobile Health Clinic, expanding maternal and child health care access across 17 rural counties

UAB launches Moms and Kids Mobile Health Clinic, expanding maternal and child health care access across 17 rural counties

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Apr 2 • 8:00 AM EDT • Health • uab.edu
Guest Commentary: Teaching Kids to Cook is Public Health

The CEO of Vetri Community Partnership on what the loss of federal SNAP-Ed funding might mean — and how you can help

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Apr 2 • 6:00 AM EDT • Health • thephiladelphiacitizen.org
Real Madrid and Barcelona plan wonderkid acquisitions for summer rebuild

Barcelona are ahead of Real Madrid in the La Liga title race, with Hansi Flick’s side four points clear at the top. But with nine games remaining in the season, Madrid will also fancy their chances...

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Apr 2 • 6:00 AM EDT • Sports • sports.yahoo.com
New Research Reveals 2 Most Dangerous Cleaning Products to Have Around Kids

Household injuries send thousands of children to the emergency room every year. Researchers reveal which common cleaning products are the most dangerous.

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Apr 2 • 5:00 AM EDT • Health • today.com
Sharks Locker Room: Team of Destiny?

Randy Hahn said it. View this post on Instagram And maybe, just maybe, after a five-game losing streak around the Olympics and a recent six-game skid that really shook the faith…maybe the San Jose Sharks are a team of destiny? With 28 seconds to go, the Sharks edged the Anaheim Ducks 4-3, for their third-straight […] The post Sharks Locker Room: Team of Destiny? appeared first on San Jose Hockey Now.

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Apr 2 • 3:40 AM EDT • Sports • sports.yahoo.com
Play every sport, try something new at Canlan Sports Camps

Kids ages 5-12 stay active at Canlan Sports Camps in Lake Barrington and Libertyville with sports, team games, pop-up activities and extended care options.

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Apr 1 • 1:37 PM EDT • Sports • chicagoparent.com
Turn the Page with Paige: ‘St. Louis Sports for Kids’ by Joey Zanaboni

You hear it all the time - St. Louis is a sports town. But it’s only going to stay that way if the next generation learns the love of the game.

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Apr 1 • 7:32 AM EDT • Sports • firstalert4.com
Can regional sports networks survive, or even thrive? Depends on who you ask

Charlie Jacobs, the CEO of hockey’s Boston Bruins, is convinced that his three children, all in their twenties, will likely never sign up for a traditional cable package to watch television. But his kids will certainly have WiFi in their homes, and through the internet, the ability to watch sports teams all the same. For years, a central question in sports and media has been whether streaming subscribers, as Jacobs’ children would be, could ever drive enough revenue to fill sports stations’ tills. Now, some regional sports networks such as New England Sports Network, or NESN, are...

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Apr 1 • 5:30 AM EDT • Sports • nytimes.com
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Durham family turns leukemia journey into mission to house pediatric patients’ families

The Durham nonprofit, started by a 12-year-old cancer survivor and her mom, provides housing to families with kids at Duke Children’s Hospital.

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Apr 1 • 4:45 AM EDT • Health • northcarolinahealthnews.org
Mental health education for coaches can help young athletes on and off the field

By Erin Harrop Youth athletics have become significantly more intense and competitive. The physical effects of training or injury can be grueling — but so are the mental health effects, particularly as performance pressure increases. As leaders and mentors, coaches play a vital role in building kids’ and teens’ confidence and shaping how athletes value […]

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Apr 1 • 2:45 AM EDT • Health • coloradopolitics.com
Suspension lifted for helicopter pilots who hovered near Kid Rock's home

U.S. Defense Secretary Pete Hegseth says the Army pilots who hovered two helicopters near Kid Rock’s Tennessee home during a training run while he clapped and saluted have had their

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Mar 31 • 7:53 PM EDT • Entertainment • yakimaherald.com
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Deborah Glick: SCOTUS ruling on conversion therapy ban will harm LGBTQ+ kids

An 8-1 high court majority sided with a Christian counselor who argues the law banning talk therapy violates the First Amendment.

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Mar 31 • 6:00 PM EDT • Politics • spectrumlocalnews.com
American journalist Shelly Kittleson kidnapped in Baghdad

American journalist Shelly Kittleson was kidnapped in Baghdad, Iraq, on Tuesday, sources and her media outlet said.

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Mar 31 • 5:39 PM EDT • Politics • cnn.com
Thousands of Kids Enter Foster Care for Mental Health Care

The Imprint did a first-ever survey of all 50 states, asking how often parents voluntarily turn their kids over to the child welfare system.

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Mar 31 • 5:25 PM EDT • Health • imprintnews.org
The Science Museum: Creating a catapult out of household objects

The Science Museum of Western Virginia helps 7@four construct an at-home activity you can do with your kids

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Mar 31 • 4:53 PM EDT • Science • wdbj7.com
Lamar Odom's kids detail decision to skip his wedding to Khloé Kardashian: 'I never even met her'

Lamar Odom's kids LJ and Destiny detail their decision to skip their father's wedding to Khloé Kardashian in the Netflix documentary 'Untold: The Death & Life of Lamar Odom.'

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Mar 31 • 3:28 PM EDT • Entertainment • ew.com
Supreme Court Allows Licensed Mental Health Practitioners to…

HRC President Kelley Robinson: “To undermine protections that keep kids and families safe from these abusive practices is shocking — and our children…

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Mar 31 • 10:34 AM EDT • Health • hrc.org
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Ron DeSantis addresses first-cousin marriages, which are still legal in Florida

As of now, it's legal to marry your aunt or uncle's kid in Florida.

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Mar 31 • 8:38 AM EDT • Politics • floridapolitics.com
Let the kids become Easter egg hunters with these Des Moines events

The weather's getting warm and Easter is right around the corner. Here are some Easter egg hunts for some family fun.

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Mar 31 • 7:25 AM EDT • Entertainment • desmoinesregister.com
Military investigating after Kid Rock brags about U.S. Army helicopters flying over his home, will take ‘appropriate action’ if in violation

The military is investigating after Kid Rock bragged about U.S. Army helicopters flying over his Nashville mansion, and say they will take ‘appropriate action’ if in violation.

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Mar 30 • 10:41 PM EDT • Entertainment • ew.com
Clear link discovered between chronic kidney disease and periodontal disease

Emerging evidence supports a relationship between chronic kidney disease and oral diseases, according to a recent review from University of Cincinnati College of Medicine researchers published in BMC Nephrology.

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Mar 30 • 8:00 PM EDT • Health • uc.edu
Army probing video of Apache helicopters at Kid Rock’s home

The Army is investigating after musician Kid Rock posted video showing Apache helicopters hovering around his Nashville-area home.

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Mar 30 • 5:17 PM EDT • Politics • cnn.com
Army investigating after helicopters hovered alongside Kid Rock's swimming pool as he saluted

a e n technology general-news military-and-defense u-s-news entertainment | KNX News 97.1 FM

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Mar 30 • 4:05 PM EDT • Entertainment • audacy.com
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Hasbro Entertainment Hires Animation Veteran Rob Doherty as New VP of Production

Hasbro Entertainment has announced the appointment of Rob Doherty as Vice President, Production. He will oversee production across Hasbro’s expanding animation and digital content slate, supporting the company’s continued growth in the space. Doherty brings over 30 years of experience in the kids’ television industry, with deep expertise in development and international co-productions. He has […]

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Mar 30 • 2:51 PM EDT • Entertainment • animationmagazine.net
When a parent has cancer, this UNC Health tool helps guide conversations with kids

A North Carolina mom diagnosed with breast cancer at age 38 shares how she navigated telling her children. Now, a new UNC Health tool is helping more families have those difficult conversations.

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Mar 30 • 1:32 PM EDT • Health • wral.com
Sean McVay on Puka Nacua: I trust this kid's heart
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Mar 30 • 12:26 PM EDT • Sports • sports.yahoo.com
Rutgers Health study spotlights marketing of ultra-processed food in Newark

Rutgers study finds ultra-processed foods dominate Newark stores and kids’ menus, prompting parents to question marketing and nutrition.

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Mar 30 • 12:02 AM EDT • Health • njbiz.com
Science Stories in the Park

Kids and youth ages 5 to 12 will learn at Science Stories in the Park from 10 a.m. to 11:30 a.m. on Saturday, April 25, 2026, starting from the McKinley Park branch of the Chicago Public Library, 1915 W. 35th St., Chicago. Led by educators from the [...]

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Mar 29 • 1:25 PM EDT • Science • mckinleypark.news
He wants kids to love science and to see people who look like them who love it, too

Maynard Okereke, the “Hip Hop MD,” will be at San Diego’s Central Library on April 2 to share his book, “Zombie Spiders and Asteroid Blasters: 16 Incredible Ways that Scientists are Changing the World”

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Mar 29 • 9:00 AM EDT • Science • sandiegouniontribune.com
Behind the lobster merch, China’s latest tech obsession could be a game changer

At China’s hot new tech events, lobsters are everywhere – lobster balloons, lobster headbands, lobster plushies in claw machines, even live lobsters in an inflatable kiddie pool. But the attendees swarming the meet-ups are not here for the crustaceans – they’re here for the new technology they represent: OpenClaw

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Mar 29 • 12:03 AM EDT • Business • cnn.com
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Belgium dismantles USMNT 5-2 in nightmare friendly, raising World Cup alarms for Mauricio Pochettino

For the first time in the U.S. national team’s evolution under Mauricio Pochettino, this summer’s World Cup felt real and urgent Saturday.

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Mar 28 • 5:41 PM EDT • Sports • sports.yahoo.com
Local kids turn a profit, learn business skills at spring mini market

The Spring Family Fun Fair at Helen Meyer Community Center gave young entrepreneurs the opportunity to practice their business skills on Saturday.

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Mar 28 • 4:47 PM EDT • Business • reviewjournal.com
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Skidding Heat taking nothing for granted vs. Pacers

Miami Heat head coach Erik Spoelstra has been known to get the best from his teams come playoff time.

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Mar 28 • 1:40 PM EDT • Sports • cbssports.com
Big League Chew Builds 2026 Ambassador Roster Around Baseball, Softball, and Entertainment Culture

Key Takeaways Big League Chew names five brand ambassadors for 2026, spanning youth baseball, professional softball, women's baseball, and entertainment Mo'ne Davis, the first girl to win and pitch a shutout in the Little League World Series, headlines the class Jocelyn Alo, the NCAA Divis

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Mar 28 • 10:34 AM EDT • Entertainment • youthsportsbusinessreport.com
Nancy Guthrie Update: Pima County Sheriff’s Deputy Arrested for Kidnapping Charge

The 22-year-old PCSD employee has since been fired.

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Mar 28 • 10:20 AM EDT • Entertainment • gjsentinel.com
Nancy Guthrie Update: Pima County Sheriff’s Deputy Arrested for Kidnapping Charge

The 22-year-old PCSD employee has since been fired.

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Mar 28 • 10:20 AM EDT • Entertainment • kten.com
Nancy Guthrie Update: Pima County Sheriff’s Deputy Arrested for Kidnapping Charge

The 22-year-old PCSD employee has since been fired.

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Mar 28 • 10:20 AM EDT • Entertainment • laconiadailysun.com
How the landmark verdict against Meta and YouTube could hit their businesses

Meta and Alphabet, the parent company of YouTube, saw their stock price drop this week after a jury found the companies liable for the design and operations of their platforms, harming a young user.

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Mar 28 • 6:00 AM EDT • Business • latimes.com
How baseball imitates life: Authors share tips for sports parents

What do Derek Jeter, Yoshinobu Yamamoto and "Seinfeld" have in common? They provide examples of how baseball lessons can help our kids succeed.

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Mar 28 • 5:06 AM EDT • Sports • usatoday.com
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From The Magic Faraway Tree to 5 Seconds of Summer: your complete entertainment guide to the week ahead

Enid Blyton’s classic kids’ fantasy novel gets the big-screen treatment, while the Aussie boyband hit the UK’s arenas

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Mar 28 • 2:00 AM EDT • Entertainment • theguardian.com
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Texas Youth Sports Leagues: A world with little oversight - what families can do

After KPRC 2’s investigation into Katy American Little League, families across the Houston area are raising similar concerns, highlighting a lack of oversight in youth sports — and what parents can do to protect their money and their kids.

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Mar 26 • 8:34 PM EDT • Sports • click2houston.com
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Youth Sports on Sunday Morning: Four Decisions and Their Dangers

Youth sports increasingly competes with Sunday worship. How can parents of sports-playing kids faithfully navigate this tension?

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Mar 26 • 8:00 PM EDT • Sports • desiringgod.org
OU STEM students encourage curiosity in young minds for Atlanta Science Festival

Oglethorpe students participated in the Atlanta Science Festival, inspiring kids and their families with hands-on science activities.

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Mar 26 • 2:15 PM EDT • Science • oglethorpe.edu
Vaccines for healthy pre-teens and teens

Adolescents ages 9-18 are due for key vaccines. Uninsured youth can get free vaccines from the City of Berkeley Immunization Clinic. Parents of uninsured adolescents can come to the City of Berkeley immunization clinic to check their child’s vaccination status and, if needed, catch up on their missing shots.Staying up to date on vaccines is important for families at a variety of ages. Adolescence is an important time to check vaccine status as kids age 9 to 18 can get proven protections to help protect against of a variety of diseases.

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Mar 26 • 1:00 PM EDT • Health • berkeleyca.gov
How Robinhood's chief brokerage officer tells his kids to invest

Steve Quirk shared four stock indexes to have in your core portfolio. He recommends focusing on diversification, with some cash set aside for single stocks.

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Mar 26 • 10:29 AM EDT • Business • businessinsider.com
Trans kids in limbo as Trump takes ‘unprecedented’ actions to limit health care

The Trump administration is trying to strongarm hospitals into shutting down their gender-affirming care programs for minors.

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Mar 26 • 5:01 AM EDT • Health • wgbh.org
RAM Crisis Is Forcing Super-Popular Kids Console To Raise Prices Again

The Nex Playground, which has at times outsold the Xbox and PS5, is getting a $50 price bump next month

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Mar 25 • 4:30 PM EDT • Technology • kotaku.com
Randolph College to host Science Festival, in celebration of all things Science

What started as a kids festival has grown into a very popular week-long event.

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Mar 25 • 3:00 PM EDT • Science • wdbj7.com
Keeping your kids in the game: Preventing sports injuries

For kids, playing sports isn’t just fun; it builds teamwork, confidence, and skills, but as any parent knows, injuries can happen.

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Mar 25 • 11:50 AM EDT • Sports • wafb.com
Bodybuilding legend Lee Haney seeks living kidney donor as family goes public with health struggles

Eight-time Mr. Olympia champion Lee Haney is urgently seeking a living kidney donor after his son revealed the bodybuilding legend's kidney is failing.

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Mar 25 • 11:30 AM EDT • Health • foxnews.com
Madeline Shepley on the Wonders of Faith and Science

Madeline Shepley discusses sharing the wonder of the universe with kids, her role as a Catholic scientist, and her love of science fiction.

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Mar 25 • 8:00 AM EDT • Science • wordonfire.org
How I Learned to Stop Worrying and Love the New York Yankees

A feel-good story about winning, losing, raising kids, the joy of sports, and, well, the Battle of Stalingrad.

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Mar 25 • 8:00 AM EDT • Sports • esquire.com
Down another regular, Warriors try to extend Nets' skid

The injuries keep piling up for the Golden State Warriors, who will be without yet another regular when they face the Brooklyn Nets on Wednesday in San Francisco.

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Mar 24 • 8:08 PM EDT • Sports • cbssports.com
Meta found liable in New Mexico suit for failing to protect children

A jury in New Mexico found Meta liable for failing to protect kids from sexual exploitation across its social media platforms.

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Mar 24 • 6:15 PM EDT • Business • businessinsider.com
Advancing Science, Students Provide Fun and Free STEM Programs for Low-Income Youth

Alyssa Huang seriously loves science and math. And she’s on a mission to make every kid feel the same way.

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Mar 24 • 4:12 PM EDT • Science • pacificsun.com
Live Entertainment on Local Stages this Spring

Warmer weather, blooming flowers, and extra daylight aren’t the only seasonal delights to enjoy this spring. There’s also a whole new crop of live entertainment! Here’s what you can see on s…

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Mar 24 • 12:59 PM EDT • Entertainment • kidfriendlydc.com
Magic face urgency to end skid vs. rising Cavaliers

James Harden and Donovan Mitchell took turns rescuing the Cavaliers on their three-game road trip, allowing Cleveland to sweep the Milwaukee Bucks, Chicago Bulls and New Orleans Pelicans.

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Mar 24 • 5:29 AM EDT • Sports • cbssports.com
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Adaptive Sports for Kids Kicks Off Opening Day With Heart, Community, and Big Smiles
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Mar 23 • 11:34 PM EDT • Sports • 12newsnow.com
Sarah Michelle Gellar says she and Reese Witherspoon were too shy to ask Adele for a play date

Sarah Michelle Gellar says she and Reese Witherspoon were both too nervous to ask Adele if they could schedule a play date for all of their kids: 'None of us wanted to ask.'

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Mar 23 • 10:00 PM EDT • Entertainment • ew.com
NMSU’s ‘Big Bang Bash’ invites community to hands-on art and science experience

New Mexico State University’s College of Arts and Sciences welcomes kids of all ages to this year’s “Big Bang Bash: Where Arts and Sciences Collide” from 5:30 to 8:30 p.m. Thursday, April 2 at...

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Mar 23 • 3:48 PM EDT • Science • newsroom.nmsu.edu
Across Tanzania, Medical Refrigerators Preserve Life and Health for Kids with Diabetes

The technology Tanzania’s children with diabetes needed most urgently wasn’t a cutting-edge treatment. It was refrigeration. Local public health clinics across Tanzania provide monthly checkups for…

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Mar 23 • 6:48 AM EDT • Health • directrelief.org
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Berrien County Health Department will hold free hearing, vision screenings for kids

The Berrien County Health Department will offer free hearing and vision screenings for kids throughout spring break.Clinics will be held March 30 at the departm

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Mar 23 • 5:31 AM EDT • Health • wsbt.com
Devin Booker gets 100% on Suns’ playoff seeding chase

Devin Booker knows where the Suns sit amid their previous five-game skid and how it impacts the playoff seeding chase.

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Mar 23 • 1:30 AM EDT • Sports • sports.yahoo.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Third-generation cafeteria owner won't force his 4 sons to take over

Michael Greene, who runs Matthews Cafeteria, shares the highs and lows of managing a family business, and why his kids may not take over one day.

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Mar 22 • 8:55 AM EDT • Business • businessinsider.com
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Healthy Kids Day collaboration with PTO Science Night, April 17

FROM FACEBOOK__Get ready for an action-packed evening! This year, the Bluffton YMCA Healthy Kids Day is joining forces with the Bluffton Schools PTO Science Night for one massive community event!

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Mar 21 • 8:00 PM EDT • Science • blufftonicon.com
Lacrosse player-turned-entrepreneur has ideas to fix youth sports

Dan Soviero's Signature Athletics zeroes in on fixing a “broken” system. Its goal is to get 10 million new kids playing by 2030. How can he do it?

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Mar 21 • 5:59 AM EDT • Sports • usatoday.com
Billionaire John Caudwell's rules for parenting his 8 kids

British billionaire John Caudwell says he flies his kids economy, shops at Primark, and always tells them he loves them.

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Mar 21 • 5:59 AM EDT • Business • businessinsider.com
Four Key Moments: Hearing on Improving Kidney Health Through Better Prevention and Innovative Treatment

WASHINGTON, D.C. – Medicare’s coverage and reimbursement policies for chronic kidney disease (CKD), and its most severe form, end-stage renal disease...

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Mar 20 • 11:43 AM EDT • Health • waysandmeans.house.gov
He's one reason why aid cuts weren't as dire for the HIV population as predicted

Harerimana Ismail of Uganda is a community health worker who checks on kids with HIV. He lost his salary after the Trump administration's aid cuts but he keeps doing his job.

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Mar 20 • 8:10 AM EDT • Health • npr.org
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Lesson about lichens spurs kids' curiosity

A rainy day led a science club leader to teach third-graders about lichens, sparking curiosity and learning.

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Mar 20 • 4:46 AM EDT • Science • tuscaloosanews.com
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12 hours, 4 games, 1 unavoidable truth: There is nothing better than the first day of March Madness

The thing that always gets me on the first day of the NCAA Tournament are the school buses, the ones chugging along stuffed with kids. Because it is, of course, Thursday morning and this is what ordinary people do on a Thursday morning.

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Mar 20 • 12:46 AM EDT • Sports • cnn.com
The right time to sign a child up for sports and why you should do it

Younger kids can learn no-contact, low-structure sports, while it takes more maturity to handle physical, structured sports.

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Mar 19 • 6:00 AM EDT • Sports • columbiamissourian.com
The teens hooked on sports betting apps

Underage gambling has become a popular extracurricular activity for high school and middle school kids, sometimes with dangerous consequences.

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Mar 19 • 5:01 AM EDT • Sports • nbcnews.com
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If states ban fluoride, kids with cavities and Medicaid costs could spike, study finds

If five states ban fluoride in drinking water, 132,572 additional children would need a cavity filled or a tooth pulled.

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Mar 19 • 5:00 AM EDT • Health • nbcnews.com
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Keaton Wagler earns All-American honors and jersey banner

Greenville, S.C. — The preseason hype surrounding a kid named Keaton Wagler felt rather obscure back then. Today, Keaton Wagler is considered one of the recent great Illini to grace the wooden State Farm Center court. On Tuesday, Illinois freshman Keaton Wagler was named to the All-American Second Team, the first Illini Freshman ever to […]

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Mar 19 • 1:06 AM EDT • Sports • sports.yahoo.com
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Tom Brady Reveals the Sneaky Way He’s Able to Watch His Kids’ Sports Games in Person

Tom Brady shared how he avoids being recognized while cheering for his three kids at their sports games, opting to keep the focus squarely on them “where it should be.”

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Mar 18 • 1:07 PM EDT • Sports • eonline.com
🧪 Science with Sarah: Invisible ink 🕵️

Let your kids use the power of science to hone their spy skills.

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Mar 18 • 11:34 AM EDT • Science • ksat.com
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Colorado voters will decide whether to ban trans kids from gendered sports, outlaw gender-affirming surgery for children

Voters will also be asked whether to make child sex trafficking punishable by life in prison without the possibility of parole

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Mar 17 • 5:00 PM EDT • Sports • coloradosun.com
1,000 Eggs Await Kids at Rome Art Center Easter Hunt

Families can look forward to a free Easter egg hunt for children ages one to nine at the Rome Art and Community Center.

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Mar 17 • 1:22 PM EDT • Entertainment • wktv.com
NEWS CENTER Maine

Through in-depth storytelling, through direct contact on digital on social platforms, through long-standing community service programs like Coats & Toys for Kids, Project Heat and Buddy to Buddy, NEWS CENTER Maine is dedicated to keeping Mainers connected. We can't do it alone, though. Only by listening and interacting with YOU can we continue to connect ALL Mainers.

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Mar 17 • 1:06 PM EDT • Sports • youtube.com
Legislation shifts too big a burden onto family court

By Judi Atwood I know what a family-court snafu looks like because I lived one. In military slang, a snafu is a breakdown so confused and badly managed the people trapped inside it pay the price. In my own case, the court adopted and preserved findings about my conduct even though I was never served, […]

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Mar 17 • 1:45 AM EDT • Politics • coloradopolitics.com
Federal judge halts RFK Jr.'s changes to children's vaccine policies

In a rebuke, a federal district court judge blocked the administration's reduction in the number of immunizations recommended for kids and also changes to an influential vaccine committee.

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Mar 16 • 7:03 PM EDT • Health • npr.org
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Consumer Reports: Preventing kids' sports injuries

Consumer Reports has important advice for parents on how to help prevent common and often avoidable sports injuries.

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Mar 16 • 6:29 PM EDT • Sports • wisn.com
Coal Ridge athletic director named best in state after landmark year of Titans prep sports

Ben Kirk did not dedicate his life to the art of sports for recognition or praise. He did it because he knows how much sports can shape a young kid, and how much impact a...

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Mar 16 • 5:45 PM EDT • Sports • postindependent.com
Opinion: New Book Helps Teachers Implement Science of Reading in Their Classrooms

Get kids reading fluently. As much as you can. Have them read and write about books. That, more or less, is the key to translating the science of reading into classroom practice, according to a new bo...

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Mar 16 • 12:30 PM EDT • Science • yahoo.com
Girls in Math and Science Day welcomes young scientists with unique STEM experiences

The Mid-Michigan Graduate Women in Science chapter and campus RSO hosted a Girls in Math and Science Day on March 14. This year’s event had the highest attendance since the pandemic, with an estimated 150 kids, 150 volunteers and 80 parents in attendance.

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Mar 16 • 8:00 AM EDT • Science • statenews.com
Reimagined children’s gallery opens in Fort Worth Museum of Science and History

Cook Children’s Medical Center helped design a new medical play space aimed at making kids less afraid of hospitals.

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Mar 15 • 7:16 PM EDT • Science • fortworthreport.org
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Girls & Science 2nd Saturday

2nd Saturdays at CSU Spur are free and open to the public for lots of family-friendly programming, including cooking activities in the CSU Spur kitchen, opportunities to watch veterinarians perform surgery on dogs and cats, see horses assisting with human therapies, engage with scientists at work, and play in a kid's kitchen and kid's vet clinic - allowing kids to become a veterinarian for the day and fix up stuffed animals.

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Mar 15 • 6:43 PM EDT • Science • cbsnews.com
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Oscars 2026 red carpet: The best fashion looks

The best fashion from the 2026 Oscars red carpet, including Nicole Kidman, Elle Fanning, Teyana Taylor, Chase Infiniti and the women of 'KPop Demon Hunters.'

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Mar 15 • 4:31 PM EDT • Entertainment • latimes.com
Too many (or too few) kids can kill you faster — this is the optimal range
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Mar 15 • 10:46 AM EDT • Health • nypost.com
Peterborough volunteers wanted to become kidney health educators

There is a higher incidence of kidney disease among some immigrant communities, says a charity.

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Mar 15 • 2:21 AM EDT • Health • bbc.com
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Science Saturday at Smith teaches kids about food and energy

The first Science Saturdays at Smith was held in the Sixth Street Museum District on Saturday.

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Mar 14 • 8:45 PM EDT • Science • wdam.com
Jamie Lee Curtis tears up remembering Nicole Kidman's touching first words to her when they met at the Oscars

Jamie Lee Curtis got choked up at a SXSW panel this weekend recalling Nicole Kidman's touching first words to her when they met at the 2022 Oscars: 'I see who you are.'

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Mar 14 • 6:17 PM EDT • Entertainment • ew.com
Ultra-Processed Foods Bad For Bone Health, Researchers Say

By Dennis Thompson HealthDay ReporterFRIDAY, March 13, 2026 (HealthDay News) — “That stuff will make your teeth rot.” For decades, parents have tried to steer kids away from junk food with that simple warning. It turns out such food is bad for your bones as well, a new study says. People who eat more ...

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Mar 13 • 6:45 AM EDT • Health • usnews.com
Washington faces Boston on 8-game road skid

Boston is third in the Eastern Conference with 33.5 defensive rebounds per game led by Nikola Vucevic averaging 6.6. The Wizards are 11-30 against Eastern Conference opponents. Washington gives up 123.9 points to opponents and has been outscored by 11.1 points per game.

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Mar 13 • 2:03 AM EDT • Sports • sports.yahoo.com
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