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As elective surgical volumes drag in 2026, health system execs say solid demand is still in sight
Though surgical volumes were a sore spot for major for-profit health systems in the opening half of 2026, executives said this week they are optimistic those service lines will stay afloat for the | In fireside chats this week, leaders of the country's largest for-profit systems acknowledged a slowdown in demand that will generally continue through 2026. They also affirmed continued investments to meet future anticipated demand, particularly in ambulatory settings.
TIME Convenes Leaders Shaping the Future of Health for Third Annual TIME100 Health Leadership Forum
TIME convenes the third annual TIME100 Health Leadership Forum in New York City, featuring conversations on equity, longevity, and solution-driven care with leaders taking action toward a world with more reliable healthcare solutions.
Sunderland forward ready to play a part says Le Bris
Régis Le Bris says Chemsdine Talbi has shown he is “all in” with Sunderland after putting the uncertainty surrounding his future behind him.Talbi was the subject of transfer speculation during th...
WVU physicist advances quantum materials research with NSF CAREER award
With support from a prestigious National Science Foundation CAREER award, West Virginia University physicist Subhasish Mandal is working to supply future quantum technologies with materials that will be required to build quantum computers and other advanced technologies.
'Everybody's a future ally': Arizona officials champion 'Disagree Better' campaign to bridge political divides
Moon's surface will be mapped in incredible detail using first-of-its-kind AI, NASA and IBM reveal
IBM and NASA have partnered to create the Lunar Foundation Model, a new AI capable of processing decades of lunar data so we can more accurately map the moon's surface.
“The Shards’ ”Igby Rigney speculates how ‘big bomb’ in season 1 finale can impact the show’s future
The actor pitches an “insane twist” to EW for a potential second season.
Blockbuster Myles Garrett trade defined NFL offseason and future of two teams
Myles Garrett was traded from the Browns to the Rams during the 2026 NFL offseason. Here's the full details of how the blockbuster came together.
Zia Yusuf: the polarising figure in Reform’s ranks
Self-styled ‘shadow home secretary’ is a ‘slowly ticking timebomb’ who could scupper his party’s chance of power, say critics
Pa. Republican lawmakers say proposed Department of Health regulations pose privacy concerns
Pennsylvania’s Department of Health is facing widespread pushback from Republican lawmakers who say the agency’s plan for how it would respond to future infectious disease outbreaks would give health officials
GTA 6 DualSense pre-orders LIVE — how to secure your limited-edition PS5 controller today
Add some Vice City to your PS5 setup
Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year
The New Orleans Saints have a lot of reason for optimism coming into the 2026 season, and a lot of that has to do with second-year quarterback Tyler Shough . Shough didn’t begin his rookie season as the QB1 in New Orleans, but he took over for Spencer Rattler midseason and gave Saints fans hope that he might be the quarterback of the future. Now, […] The post Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year appeared first on ClutchPoints.
O’Gorman motivated for 48th Dakota Bowl
SIOUX FALLS (KELO) – The Dakota Bowl is one of the biggest football games of the year for O’Gorman High School, which is something future Knights are taught from a young age. “I think our players, starting with all six of the guys that we had here today, that started our council, were kindergartners that […]
Xbox has acquired rights to publish Hideo Kojima's 'PHYSINT' from PlayStation — "We're honored that Kojima-san has chosen to work with Xbox."
In a major coup, Xbox has confirmed that it will be publishing Hideo Kojima's long-awaited action-espionage title "PHYSINT."
Future of Health Asia 2026 to connect policy, finance and care for sustainable health systems
Economist Enterprise will host the 6th Future of Health Asia on September 29th at the Grand Hyatt Singapore. This premier event convenes over 500 industry, medical and government leaders to address the structural forces reshaping healthcare across the region.
'America's Nobel' prizes go to sleep and hemophilia researchers, and to Michael J. Fox for Parkinson's advocacy
The Lasker Foundation has announced the winners of its 2026 awards for basic medical research, clinical science and public service.
Scientists Rebooted This Forgotten Battery—and It Recharges in Seconds. This Could Be the Future of Energy.
They last more than 12,000 charge cycles—and could be the solution for power-hungry data centers.
Michael J. Fox explains why he returned to acting with “Shrinking”: ‘Allows me to show up on set as myself’
The “Back to the Future” star said that the show allowed him to “use how I feel on any given day and channel it into the scene.”
Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1
The New Orleans Saints still have some questions to be answered at the wide receiver position.If Bryce Lance reaches his potential quickly, though, that could solve a lot of potential issues.And there appear to be at least some people around the league who are big believers in Lance.The Saints took Lance in the fourth round […] The post Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1 appeared first on HEAVY.
Apple's Fine Print: Daily Usage Limits for Siri AI, 'Expanded Access' Coming for a Fee
Apple today confirmed that there will be a daily usage limit for Siri AI, with expanded access available for a fee in the future. In the fine print of Apple's announcement of the Health Sensing features coming to the Apple Watch Series 12 and Apple Watch Ultra 4, Apple says it will have usage limits on Siri AI, intelligent photo editing tools, Image Playground, and Apple Foundation Cloud models in the Shortcuts app.
Appeals court considers future of nationwide access to medication abortion
The issue of medication abortion was back before a New Orleans-based appeals court on Wednesday, in the latest iteration of a years-long legal effort to end the provision of abortion drugs via telehealth.
‘There is no excuse of ignorance about the AfD’s rise’
Opinion, comment and editorials of the day
Héctor Socas, astrophysicist: ‘If a more advanced civilization contacted us, they should be more afraid of us than we are of them’
Artificial intelligence, extraterrestrial life, the climate crisis, the future of work and global governance. This science communicator uses the lens of science to tackle a much broader question: what kind of civilization do we want to be?
See the highest-resolution footage of a black hole jet ever taken, thanks to AI and 27 years of observations
Researchers combined 100-plus images of a single black hole into an AI-powered video to chart the activity of a mighty blazar's jet.
Business alumni board builds momentum for future engagement
The inaugural Business Titans Alumni Board Summer Retreat brought alumni together for a collaborative and productive day on July 24 focused on shaping the new advisory board, strengthening connections and helping define the future of alumni engagement at the Cal State Fullerton College of Business and Economics. During the retreat, board members discussed priorities and identified […]
Shaping the Future of Public Health and Policy in Mexico
Mexico is transforming public health into a strategic pillar, linking healthcare reform with investment, research, regulation and domestic production.
Can Meister emulate Agyemang at Derby?
Derby County talent acquisition lead Leigh Bromby says the club signed Henrik Meister this summer with big expectations and an eye on the future.
Do you think Al could ever become self-aware?
A new study looks at "consciousness steering" in AI, but could this technology actually achieve this level of self-awareness in the first place?
Business Must Become A Co-Designer Of Talent
Why the Future of Education Depends on Employers Becoming Partners in Learning
Museum of Discovery and Science, Broward libraries bring hands-on learning to communities
The Museum of Discovery and Science and Broward County Library are bringing hands-on learning and character development to communities across Broward County through Character Corners, an initiative inspired by MODS’ Build a Better World: The Future Begins with You exhibit.
Smithsonian head retiring amid Trump pressure
Lonnie Bunch III has led the institution since 2019
Poll shows two-thirds of U.S. Jewish voters will favor Democrats in November
Despite tensions over Israel and rising antisemitism, respondents ranked affordability and the future of democracy as their top issues in the midterms.
The moon may have formed in just 5 hours, new simulations suggest
Novel simulations, which reassessed the ancient collision between Earth and the protoplanet Theia, suggest that the moon could have emerged from the aftermath of this impact much more quickly than scientists previously thought.
Save 40% on Autodesk’s Media and Entertainment Collection — thousands of dollars worth of software in a single bundle
Big savings for big ideas
Optimism index: Small business owners feel good now, are wary about future
The National Federation of Independent Business released its August small business optimism index on Tuesday and it showed a small dip to a reading of 98.7 from 99.8 in July. But the optimism index remained just above its long-term average …
Blizzard Workers Ratify Union Contract With Microsoft
Blizzard's many disparate unions are also being condensed into three groups for ease of future bargaining
A photon from the biggest cosmic explosion since the Big Bang appears to have defied Einstein. Scientists may finally know how
"We started from a very simple question: how did this photon survive a journey that, according to known physics, should have destroyed it?"
What impact will UK’s West Bank sanctions have?
‘Biggest reset in UK relations with Israel for decades’ is not without ‘political risks’
Beyond Bottlenecks: The Strategic Future of Mexico Healthcare
Mexico must tackle COFEPRIS delays, USMCA uncertainty, and long payment cycles to build a competitive healthcare industry, writes Deyanira Chiñas.
Kansas City Royals news: Witt’s future looks Golden
What will end first; the Kansas City Royals’ season or the heatwave the Midwest is suffering through?
PROJEKTIL | 10th anniversary & the future of immersive
The founders reflect on a decade of immersive storytelling, from artist collective to international touring studio
Scientists and algorithms: Finding the right balance in modern drug development
The future of drug development is not scientists versus algorithms. It is scientists and algorithms working together.
Europeans struggle to imagine 'credible' future, study finds
New research identifies an 'imagination gap' as where political choices can still matter
Europeans struggle to imagine 'credible' future, finds study
New research identifies an 'imagination gap' as where political choices can still matter
Angel Reese Is Getting Way Too Good to Ignore
At some point, we have to stop calling Angel Reese a “future star.” She is already a star. Reese has taken her game to another level with the Atlanta Dream, averaging 16.1 points, 12.4 rebounds, 2.8 assists and 1.8 steals per game this season. And somehow, she still feels like one of the most underrated…
A path toward justice and public safety
Strangulation can be one of the most dangerous forms of assault; despite the lack of visible ailments it is accompanied by. Though strangulation leaves no broken bones, bruises or visible wounds, it is one of the strongest predictors of future homicides for domestic violence victims. Until this year, second-degree assault by strangulation was not classified […]
England to extend head coach Borthwick's contract
England head coach Steve Borthwick will have his contract extended past the 2028 Six Nations in a bid to avoid uncertainty over his future before and during next year's Rugby World Cup.
OM System PEN review: Get the F out! This camera isn't a PEN-F II – but it's better in every single way
The OM System PEN is the ultimate everyday carry – and in many ways, a better Lumix L10 than the actual L10
Dana White Comments on Michael Page’s UFC Future
UFC president Dana White confirmed that the promotion has no interest in re-signing Michael Page after the conclusion of his contract.Page just finished his six-fight UFC contract with a 5-1 record, but his fights were not exciting to watch, and the UFC had no interest in re-signing him.Dana White Confirms Michael Page Is No Longer […] The post Dana White Comments on Michael Page’s UFC Future appeared first on HEAVY.
Hawaiian Telcom Unveils Future-Ready Business Fiber Platform Engineered for 10 Gig Connectivity
Hawaiian Telcom announced enhancements to its business fiber internet portfolio, including expanded symmetrical upload and download speeds across Fioptics Business Internet plans and the introduction of Fioptics Advanced WiFi for business customers. Together, these enhancements provide Hawaiʻi businesses with faster, more scalable connectivity backed by a fiber network engineered to support connectivity solutions up to 10 Gig.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ SK hynix Vice President Jaewuk Ju, head of the Smart Manufacturing Technology/AX Advance department, delivering the first keynote presentation
LIV Golf files bankruptcy with post-Saudi Future uncertain
LIV Golf filed for bankruptcy protection Tuesday, a dramatic fall for the Saudi-backed league that had big ambitions to challenge the supremacy of the PGA Tour. Saudi Arabia’s Public Investment
Future Of Jimmy Kimmel's Late-Night Show In Doubt Following Bombshell Report
A spokesperson for ABC said no final decision has been made about the future of the show.
Joe Burrow Sends Clear Message About His Future in Cincinnati
After his “This is it” comments sparked speculation, Joe Burrow clarified his intentions and reaffirmed his commitment to Cincinnati.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ A panoramic view of the 2026 SK hynix Future Forum venue On September 8, SK hynix held the 2026 SK hynix Future Forum (Future Forum) at the SUPEX Center on its Icheon Campus under the theme, “The Golden Time
Ubisoft joins Xbox's disc-to-digital program, with more publishers to follow
Some outlets were highlighting Ubisoft's lack of involvement in Xbox's disc-to-digital program. Perhaps we should remind ourselves that it's still in Alpha testing.
A study links prenatal acetaminophen with reproductive changes in girls. Doctors say it remains safe to use when needed
A new study found that some girls born to mothers who took acetaminophen during pregnancy developed reproductive organ changes that could affect fertility later in life. It’s a finding the study authors say should drive future research but shouldn’t yet change how certain symptoms are treated during pregnancy.
Colisée’s new owners pledge to ‘bring life back’ to Lewiston’s top entertainment, sports venue
The New York-based owners say the sale signifies a serious future investment in professional hockey in the city, as well as youth hockey, community events and more.
Hegseth claims another scalp in Pentagon purge
Dan Driscoll resigned and warned the resident that Secretary of Defense Pete Hegseth is doing serious damage to the military
NASCAR CEO on future business growth: All about partnerships
Steve O’Donnell, NASCAR CEO, and Matt Hong, USA Sports president, join 'Closing Bell' to discuss the business of NASCAR, how to keep business momentum and much more.
Arsenal youngster in international tug-of-war
Ceadach O’Neill’s international future remains unresolved, with Northern Ireland and the Republic of Ireland both still possible options for the Arsenal youngster.Photo by Cameron Smith/Getty Imag...
Celo to Participate in Merkle Science Meet in Washington, D.C. on September 8th
Celo will participate in Merkle Science Meet in Washington, D.C. on September 8th at 18:00 UTC. Markus will join a panel on the GENIUS Act and the future of U.S. stablecoin regulation.Refer to the official tweet by CELO:Kicking off @thestablecon week today, @MarkusMento speaks at @MerkleScience Mee…
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
The best gadgets and gear that debuted at IFA 2026
Why wait for the future of technology to arrive when you can see it now? Here are the most exciting gadgets from Europe's biggest tech expo.
If AI thinks it's conscious, it's more likely to believe in vampires, karma and ghosts, new study shows. What does it mean for how we use it?
A new study shows that measures to stop AI's claims of consciousness have unintended consequences for non-human entities
Future Leader: Haven Banks, Director of Marketing & Outreach, MiraSol Health
Haven Banks, Director of Marketing & Outreach at MiraSol Health, has been named to the Future Leaders Awards Class of 2026 by Hospice News. To become
BlizzCon 2026 preview: Speculation, hopes, dreams — what to expect for Warcraft, StarCraft, Overwatch, Diablo, and even more surprises
BlizzCon 2026 is shaping up to be incredibly special this year, with a huge amount of panels, unexpected surprises, alongside some perhaps a-little-more-expected surprises.
From California to the Moon: Daniel Rivers and Sally Ashton Explore the Intersections of Art and Science NewsCenter | SJSU
Two new books from San José State faculty take on that question through explorations of environmental justice, space, California history and the possibilities of more just futures.
Is Trump’s midterm convention a flop before the doors even open?
Trump says he wants to energize Republican candidates before the midterms. Dozens are keeping their distance anyway.
Scientists call for joint efforts to preserve nomadic heritage
At the International Scientific and Practical Conference “Cultural Heritage of the World’s Nomadic Peoples: Preservation, Study, and Development”, scholars and experts from 23 countries urged unified action to safeguard the cultural diversity of nomadic peoples and ensure traditions remain alive for future generations, Qazinform News Agency cites Kabar.
Where on Earth is safest from global catastrophe?
Researchers have worked out the safest, most resilient country to be in during an apocalyptic event.
MedStar Washington Hospital Center nurses host community forum on maternal health care cuts, the future of health care in DC
Union registered nurses at MedStar Washington Hospital Center in Washington, D.C. will hold a community forum on Wednesday, Sept. 9, 2026, to discuss the closure of postpartum unit 5F at Washington Hospital Center, the devastating impact of Medicaid cuts in DC, and building a health care system that works for us all.
How the lowly egg could help protect future spacecraft
Bioinspired designs could be sturdy astronaut allies.
Apple’s latest acquisition is about technology that sounds futuristic
EU filings revealed today that Apple has acquired a company called Sonera, makers of wearable-centered technology that sounds futuristic.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
I’ve already picked my National Television Awards winners - here’s who I think will be bringing home the trophies
The competition is fierce, but I know who I want to come away from the ceremony with a gong
Star Stable Entertainment reduces workforce by 20% to secure long-term future of its multiplayer horse adventure RPG
Interim CEO says by "reducing operating costs and refocusing resources," Star Stable will be in the "best possible position to adapt and grow"
DeWitt’s Crossroads Business Park gets ready for growth
DEWITT, Iowa – Community leaders and development partners recently celebrated the groundbreaking of five regional water detention ponds in an expansion of the Crossroads Business Park, marking a major milestone in preparing the site for future industrial growth. The project is the first phase of infrastructure improvements that will make approximately 125 acres of development […]
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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