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‘Love and Other Words’ Adaptation a Go From Magic Hour Entertainment
Max Siemers and Tanner Anderson are behind the new company, which will adapt Christina Lauren’s best-selling novel of the same of the name centered on childhood friends turned first loves who reconnect as adults.
‘Love and Other Words’ Adaptation Set With the Newly Formed Magic Hour Entertainment (Exclusive)
Max Siemers and Tanner Anderson are behind the new company, which will adapt Christina Lauren’s best-selling novel of the same of the name centered on childhood friends turned first loves who reconnec...
Trump's FIFA call opens a 'slippery slope,' says sports columnist Christine Brennan
NPR's A Martinez speaks with USA Today sports columnist Christine Brennan about the World Cup match between the U.S. and Belgium and the lifted suspension of a U.S. star forward.
This whistleblower took on a health insurance giant and a political machine. She’s not stopping there
America’s employers must stop acting helpless in the face of health care industry profiteering, Chris Deacon says.
Labour asks Electoral Commission to investigate claims Farage broke electoral law by not disclosing gifts
Parliamentary authorities are already looking into a £5m donation to the Reform Uk leader from the crypto billionaire Christopher Harborne
USA Coach Mauricio Pochettino Gives Update On Christian Pulisic Injury
United States forward Christian Pulisic could only watch from the bench as Belgium extinguished his team’s World Cup bid, ending a tournament in which the American star was hobbled by injuries and largely ineffective.
‘The Odyssey’ first reactions: Raves for Christopher Nolan’s ‘jaw-dropping,’ ‘staggering,’ ‘must-see’ epic
First reactions to Christopher Nolan’s ‘The Odyssey’ deem the epic adventure ‘jaw-dropping,’ ‘staggering,’ and ‘the must-see cinematic event of the summer — and quite possibly the year.’
Chris Richards on Balogun red card controversy, U.S.-Belgium knockout match: "It's business as usual"
Xbox Lays Off FanFest Creator Three Months After Bringing It Back
Chris Munson was a 15-year veteran of Microsoft
49ers fans are convinced who RB2 is behind Christian McCaffrey
It is Kaelon Black’s job to lose, apparently.
NFL executives say 49ers’ Christian McCaffrey has ‘declined some’
49ers RB Christian McCaffrey is still viewed as a top 5 back
Fed's Waller says forward guidance 'more art than science'
Federal Reserve Board Gov. Christopher Waller says he is OK with dialing down the amount of communication issued by the central bank's monetary policy committee, but doesn't want the central bank to throw out the baby with the bathwater.
NC’s top business recruiter on rivals, foreign tourism dip and project pipeline
From Trump to Biden to Trump: how Christopher Chung chases jobs as federal policy shifts.
Politics Unplugged (Full Episode) July 5, 2026
State Senator Analise Ortiz discusses No Safe Seats, an effort to raise money for progressive Democrats who are challenging establishment Democrats in the state. Plus, former Democratic lawmaker Reginald Bolding and Republican businesswoman Christine Jones discuss the Supreme Court ruling upholding birthright citizenship. Then, Reginald and Christine talk about the Department of Justice investigation into Senator Roben Gallego.
Arkansas football great Bill Burnett passes at age 78
Burnett, a Bentonville High standout, owns the Arkansas csreer touchdown record (49) and his post-football legacy with the Fellowship of Christian Athletes and other organizations will live on.
D-backs vs. Brewers Discussion
Today’s Lineups BREWERS DIAMONDBACKS Brice Turang – 2B Ketel Marte – DH Jackson Chourio – LF Geraldo Perdomo – SS Christian Yelich – DH Corbin Carroll – RF Andrew Vaughn – 1B Gabriel Moreno – C Jake Bauers – RF Lourdes Gurriel – LF Garrett Mitchell – CF Ildemaro Vargas – 2B Gary Sanchez – […]
Chris Stapleton and Chaka Khan celebrate America's 250th at the L.A. Coliseum
Chris Stapleton was the headlining act at a Fourth of July benefit concert that also featured Smashing Pumpkins, Chaka Khan, Maren Morris and Queen Latifah.
Christian Horner: Former Red Bull team principal makes F1 paddock return at British Grand Prix
The Left Knows One Narrative About Conservative Women. An Eye-Opening New Book Offers Another.
Christian conservative women aren’t all alike, Katie Gaddini’s book Esther’s Army suggests.
For the 2014 film Interstellar, director Christopher Nolan hired Caltech physicist Kip Thorne as his science consultant — and the visual simulations Thorne helped design for the film's black hole were so mathematically accurate that they generated two peer-reviewed scientific papers and became the model for how astrophysicists visualize black holes today
In late 2012, when the American film director Christopher Nolan formally took over the production of a Warner Brothers science-fiction project that had been drifting through Hollywood development since approximately 2005 (originally intended for Steven Spielberg, based on a screenplay concept the film producer Lynda Obst had developed jointly with the Caltech theoretical physicist Kip […]
Lakers have signed Chris Mañon to two-way contract
The Lakers have signed defensive specialist Chris Mañon to a two-way contract.
D-backs vs. Brewers Discussion
Today’s Lineups BREWERS DIAMONDBACKS Brice Turang – 2B Ketel Marte – 2B Christian Yelich – DH Geraldo Perdomo – SS Jake Bauers – LF Corbin Carroll – RF William Contreras – C Gabriel Moreno – DH Garrett Mitchell – CF Adrian Del Castillo – C Andrew Vaughn – 1B Nolan Arenado – 3B Sal Frelick […]
Braves look for much-needed series win behind Chris Sale
The Braves will look to back Chris Sale to secure a series win, who they can expect another strong start from.
Travis Kelce marries Taylor Swift in a tux by Christian Dior
Taylor Swift may have brought the glamor to her lavish wedding weekend, but Travis Kelce brought the charm.
Taylor Swift wears Christian Dior wedding dress to marry Travis Kelce
It's a love story, and Taylor Swift picked out a dress by Christian Dior Haute Couture for her wedding to Travis Kelce. on Friday, July 3, at Madison Square Garden,
Love, science and resurrection collide in Christina Lauren’s ‘The Romance Revival’
Under the Radar speak with New York Times best-selling authors Christina Hobbs and Lauren Billings about their latest novel
Cullman Christian School Science Club raising funds for travel
Cullman Christian School Science Club raising funds for travel - The Cullman Tribune - Featured
Marshawn Lynch, Edgerrin James bring back Ice Bucket Challenge to support Chris Johnson after ALS diagnosis
FOR INSIDERS | Whole Hog Politics: A revolutionary reader
[Watch Whole Hog Politics live: Join us today at 9 am EDT at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audien…
Wing Commander IV and the FMV future that never quite was
ArsGames takes a look at the time Chris Roberts more or less made a whole movie.
Christine Lagarde leaves door open to early ECB exit, as she mulls French politics
The European Central Bank's Christine Lagarde has declined to rule out an early end to her term as president, as she mulls a foray into French politics.
Why you should wash new clothes before wearing; signs that you are aging well; effective leadership in health care; plus other stories with Vanderbilt Health sources
Jami Miller, MD, Professor of Clinical Dermatology, and David Gaston, MD, PhD, Assistant Professor of Pathology, Microbiology and Immunology, are quoted in a Southern Living piece about the importance of washing new clothes before wearing them. Dyes, chemicals, mold and bacteria are all potential troublemakers lurking around your new duds. Parul Goyal, MBBS, Associate Professor of Clinical Medicine, was quoted in a Huff Post story outlining signs that you are aging well. Tae Kon Kim, MD, PhD, Assistant Professor of Medicine, was interviewed by Healio for a story headlined, “Effective leadership in health care ‘starts with listening.’” AAMC News reporter Patrick Boyle interviewed Wes Ely, MD, Professor of Medicine and Critical Care, for a story about ICU delirium. PharmaVoice reporter Kelly Bilodeau interviewed Romney Humphries, PhD, Vice Chair and Executive Medical Director, Clinical Services, for a story about the CDC’s new data that shows an alarming increase in the prevalence of a gene that can make “nightmare bacteria” significantly harder to treat. American Community Media interviewed William Schaffner, MD, Professor of Preventive Medicine, for a piece about Ebola that was reused by several media outlets around the U.S., including The Mississippi Link. Stacie Dusetzina, PhD, Professor of Health Policy, was quoted by The Independent in a story about how Medicare will soon cover weight-loss drugs. Courtney Schadt, MD, Associate Professor of Dermatology, was interviewed by Tennessean reporter Beth Warren, about tanning safety and tanning fads circulating social media. WKRN News 2 interviewed Amanda Peltier, MD, Professor of Neurology, about the correlation between head trauma and ALS following the diagnosis of former Titans running back Chris Johnson.
Following attack, LG Health\'s nurse scientist\'s violence prevention efforts to be recognized nationally
As the punches rained down on his face, Christian Burchill was paralyzed by shock.
Rhode Island Marijuana Officials Ask Judge To Remove Block On Business Licenses Now That Rules Targeted By Lawsuit Have Changed
“We’re hopeful that once we get the go-ahead with the appropriate people that we can get the process moving again.” By Christopher Shea, Rhode Island Current Now that Rhode Island has eliminated the residency requirement for recreational pot shop owners, the state’s Cannabis Control Commission is asking a federal judge to undo the court order […]
I got laid off after 31 years at Disney
Chris Bess says a social media post about losing his Disney job reached millions and expanded his professional network.
Entertainment-focused Cosmic Sports launches black light ice hockey venture
Cosmic Sports founder Chris Martin the success of Cosmic Baseball to the ice, announcing the launch of the glow in the dark, barnstorming property Cosmic Hockey.
Chris Paul fuels return speculation with Jayson Tatum workout video
Chris Paul announced his NBA retirement on Feb. 13. However, fans are speculating that he could play for the Boston Celtics next season. It came after a video of him putting up shots at the Elite Camp on Wednesday with…
Chris MacFarland explains how he's improved Nashville Predators roster
Chris MacFarland explains how he's improved Nashville Predators roster
Priced out: The growing cost of live entertainment
Summer tours are trying to fill seats while keeping up with growing ticket prices. Tickets for the Ed Sheeran concert at U.S. Bank stadium are BOGO through the 4th of July, and the Mystic Lake Amphitheater is doing an offer of four tickets for $99 for select concerts. Meanwhile shows like Noah Kahan are having no problem selling tickets with high ticket prices. Music critic for the Star Tribune Chris Riemenschneider joins All Day to talk about the drama around concert tickets.
BBC announces major new Jesus docuseries amid biblical entertainment boom
The BBC has announced the launch of a new four-part documentary series exploring the life of Jesus Christ, marking the latest entry in a growing wave of biblical programming spurred by the success of
She and Her Mother Built an 8-Figure Business Around a Beloved Family Heirloom. Now, the Legacy Continues: ‘So Much Bigger Than Just a Product.’
Christina Livada and her late mother Beth Haller LaSala built a brand based on warmth and comfort.
Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science
The Vanderbilt Prize in Biomedical Science recognizes scientists who have a stellar record of research accomplishments.
Goodman: He could have been an international spy, but chose a different path
The soccer culture of Birmingham, Alabama, that produced Chris Richards has an unlikely origin story.
A Political Pulpit for Me but Not for Thee
A final book from Old Testament scholar Walter Brueggemann is characteristically convicting and vivid—but myopic about his progressive politics.
Yale New Haven Health System CEO steps down
Christopher O’Connor, chief executive of Yale New Haven Health System, is stepping down from his role, according to an announcement Monday.
CT health system reveals top CEO stepping down. Nationwide search to be done for replacement.
The CEO of Yale New Haven Health System is stepping down after 14 years in the post, according to the health system. CEO Christopher O’Connor joined YNHHS “after helping lead the Health System’s acquisition of the Hospital of Saint…
Nancy Guthrie demand letter’s authenticity questioned by sheriff
Pima County Sheriff Chris Nanos weighs in on a new demand letter in the Nancy Guthrie case, which claims to know who kidnapped the mother of 'Today' host Savannah Guthrie.
Former Tennessee Titans running back Chris Johnson reveals a devastating health diagnosis
Two-time All-Pro Chris Johnson reveals diagnosis at age 40.
Patrick Mahomes Shares Emotional Four-Word Message After NFL Legend’s Heartbreaking Health News
Patrick Mahomes was among the NFL stars sending support after Chris Johnson announced his ALS diagnosis. The post Patrick Mahomes Shares Emotional Four-Word Message After NFL Legend’s Heartbreaking Health News appeared first on HEAVY.
Three Chiefs Land in CBS Sports Top 100 Players
Patrick Mahomes, Creed Humphrey and Chris Jones each made the list
Former NFL star Chris Johnson makes heartbreaking health announcement
The NFL is filled with gridiron legends who sacrifice their bodies every Sunday in pursuit of a Super Bowl championship. But even the game’s greatest stars aren’t invincible. On Monday, former Tennessee Titans running back Chris Johnson revealed that he…
Titans Legend Chris Johnson Reveals Heartbreaking ALS Diagnosis
Former Tennessee Titans star and NFL great Chris Johnson shared his diagnosis publicly for the first time, hoping his story will inspire awareness, research, and hope for others battling ALS.
Texas Democrats leave convention united in effort to end GOP’s 30-year hold on state politics
Texas Democrats spent their 3-day convention in Corpus Christi rallying party activists, training volunteers and making the case for Democratic policies and candidates across the state ahead of the 2026 midterm elections.
Former Titans running back Chris Johnson announces ALS diagnosis
Former Tennessee Titans running back Chris Johnson announced he has been diagnosed with amyotrophic lateral sclerosis, or ALS.
Former Titans star Chris Johnson reveals ALS diagnosis: 'I chose to fight'
Chris Johnson is one of nine players to rush for over 2,000 yards in a single season.
Notable Rutgers grads and former students
Some notable Rutgers alumni include James Gandolfini, Chris Christie, Eric LaGrand and more.
Jaguars’ New DT Compared to All-Pro Chris Jones
Jacksonville’s interior defense gains a high-upside disruptor in Ruke Orhorhoro, a raw Clemson product whose elite frame and athleticism draw striking comparisons to the Chiefs’ superstar anchor.
BUSINESS BRIEFS June 29, 2026: Business news in the Berkshires and beyond
Business news from Christine Bilé, BFAIR, UCP of Western Massachusetts, Lipton Energy, BCC, and more.
Texas Democrats leave convention united in effort to end GOP's 30-year hold on Texas
Texas Democrats spent their 3-day convention in Corpus Christi rallying party activists, training volunteers and making the case for Democratic policies and candidates across the state ahead of the 2026 midterm elections.
Panthers rookie WR shares his offseason work in highlight tape
Panthers rookie WR Chris Brazzell II impressed at spring workouts, and he hasn't slowed down during his summer break. Check out his highlights . . .
Usher makes the case for R&B in stadiums
LOS ANGELES — As Usher prepares to launch a stadium tour with Chris Brown, he says the criticism and legal troubles surrounding the singer never factored into his decision to
Prescott, Parker present Cowboys with an 'iron sharpens iron' dynamic
Cowboys quarterback Dak Prescott has had issues solving two defensive schemes. With Christian Parker in the building, he may finally figure it out.
‘Odyssey’ fever grips the Classics world
(CNN) — As fans of Christopher Nolan eagerly await the July 17 release of his take on “The Odyssey,” a different kind of enthusiast is also bristling with anticipation: scholars
Maryland Christian Chamber of Commerce blends faith and business as membership grows
Since its launch in March 2026, the Maryland Christian Chamber of Commerce has grown to more than 100 member businesses, hosting networking events, prayer calls and monthly forums. The new organization blends Christian values with business principles to support entrepreneurs and foster a shared sense of purpose across Maryland.
Report: Crystal Palace Eye Smart Move for Experienced Arsenal Midfielder
Crystal Palace Eye Christian Norgaard as Arsenal Exit Route OpensPalace Consider Midfield ExperienceCrystal Palace appear ready to offer Christian Norgaard a route out of Arsenal this summer, with Spo...
The Chicago Bears are getting their own Hallmark Christmas movie
The Chicago Bears are the latest NFL franchise to get the Hallmark Christmas movie treatment. The team announced Thursday that it is partnering with Hallmark Media, the NFL, and Skydance Sports for Holiday Touchdown: A Bears Love Story, which will premiere during Hallmark Channel’s 17th annual Countdown to Christmas programming event this holiday season. “My…
The fittest founder in the room got cancer. Here's how he used AI to fight back.
When confronted with cancer, Connor Christou fed everything tied tied to his regime — blood results, scan data, wearable output, journal entries — into Claude.
In Trump’s America, two very different views of Christianity in politics emerge
Adherence to organized religion is falling in the United States, but defenders of the religious right are ascendant in positions of power in the Trump administration.
EAST TEXAS POLITICS: Embrace or ban? Railroad commissioner, ag commissioner candidate clash on data centers
Wayne Christian and Clayton Tucker join Blake Holland with opposing views on Texas data centers.
EAST TEXAS POLITICS: Railroad commissioner, ag commissioner candidate clash on data centers
Texas Railroad Commissioner Wayne Christian, a Republican, and Democratic nominee for Texas Agriculture Commissioner Clayton Tucker, who hold opposing views on data centers, talked with Blake Holland for this week’s edition of East Texas Politics on East Texas Now. .
Scientists Baffled by Discovery of Rare “Pink Floyd” Spider Hidden in Home Walls - Futura-Sciences
The Birth of a “Pink Floyd” Spider Tiny, discreet, and quietly settled on urban walls, a new species of spider was recently discovered in Colombia—and christened as a tribute to the iconic rock band Pink Floyd. As part of a study published in the journal Zoosystematics and Evolution, South American...
Rangers trade Brett Berard to Canadiens for William Trudeau: Sources
The deal marked the first trade between Rangers team president Chris Drury and his predecessor, the Canadiens' Jeff Gorton.
From The Sports Desk: The U.S. lost, but also saw return of star Christian Pulisic
The Americans may have lost their final group stage. But Pulisic, who had been nursing a calf injury, returned to action. He’s back just in time for the start of the knockout round.
Master Inventor Hoffman Turns Chemistry Into Capability | Johns Hopkins University Applied Physics Laboratory
Christopher Hoffman has been recognized as a Johns Hopkins APL Master Inventor, a distinction earned through a career spent asking a simple question: What can chemistry can do to solve a real-world problem?
Whole Hog Politics: It was voters, not Senate Republicans, who forced Trump’s hand on Iran
[Watch Whole Hog Politics live: Join us today at 9 am ET at TheHill.com as Chris Stirewalt and host Bill Sammon break down this week’s political news and answer questions from a live online audienc…
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
Freedom Con: Thousands of Men Gather for Christianity and Feats of Strength
Thousands of men and boys gathered in central Washington for masculinity, Christianity and right-wing politics.
World Cup 2026: Christian Pulisic won't start for USMNT's group stage finale against Türkiye
Trump nominates Chris Klomp as HHS second-in-command
President Donald Trump on Thursday named Medicare director and former health care executive Chris Klomp to be deputy secretary of the US Department of Health and Human Services.
JD Vance claims Diddy is 'not a Christian' after federal conviction
Sean "Diddy" Combs might have scored a reference in Vice President JD Vance's new book, but the politician is not eager to associate himself with the imprisoned music mogul.
Trump nominates new top deputy to RFK Jr.
Chris Klomp, a 45-year-old tech entrepreneur, gained the president's confidence when he negotiated price cuts with drug companies.
FlashPoint: How a Christian political media network became a platform for Indiana’s Lt. Gov.
By Sydney Byerly The Indiana Citizen June 25, 2026 When Indiana Lt. Gov. Micah Beckwith called Islam a “demonic death cult” during an appearance on the Christian political program FlashPoint in May, the remarks drew swift backlash from faith leaders across Indiana. It also highlighted the growing influence of the Christian media network that amplified
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Chris Evert shares devastating health update
It is the news that no one wanted to hear about Chris Evert. Amid the Netflix press tour and her upcoming ESPN commentary duties at Wimbledon, we learned on Wednesday that she quietly stepped away to deal with a health…
Brad Stevens discusses ‘excitement’ surrounding Chris Cenac Jr.
“I hope we’re good enough that it’s hard for any 18-year-old or 19-year-old to come in here and be really good out of the gate.”
South Dakota mayoral candidates separated by just two votes in shockingly close race, recount expected
The Sioux Falls mayoral runoff contest shockingly resulted in just a two-vote margin separating the candidates out of more than 36,000 ballots cast.
Texas Democrats head to convention with optimism, but questions about November remain
The Texas Democratic Convention begins Thursday in Corpus Christi. The three-day convention features several national and statewide figures in the party — this while polls show Democratic candidate James Talarico essentially even with his Republican opponent for U.S. Senate, Attorney General Ken Paxton.
The Pick Is In: Hallmark Media, NFL and Skydance Sports partner with the Chicago Bears for Holiday Touchdown: A Bears Love Story set to premiere during Hallmark Channel’s 17th annual Countdown to Christmas programming event
Hallmark Media, NFL and Skydance Sports on Thursday announced that the Chicago Bears have been drafted for Holiday Touchdown: A Bears Love Story, the third all-new original movie in the successful franchise, set to premiere later in 2026 during Hallmark C
Sports reporter sickened as prized notepads stolen
Chris Phillips' notepads contain statistics from Southend United games over the past 20 years.
Usher says tour with Chris Brown is about more than 2 stars. He makes the case for R&B in stadiums
Usher is launching a stadium tour with Chris Brown and says Brown's legal troubles never influenced his decision.
Julian Edelman's blunt advice for Patriots with Christian Gonzalez
Julian Edelman shared his thoughts on the ongoing contract situation between the Patriots and star cornerback Christian Gonzalez.
Entertainment Listing: June 24
Wednesday June 24 Little Nashville • Marion Bingo, 6 p.m. – 9 p.m. PK’s • Carbondale Trivia, 8 p.m. – 11 p.m. Advertisement Thursday June 25 PK’s • Carbondale Ethan Stephenson Band, 9 p.m. Little Nashville • Marion Chris Chamness, 6 p.m. – 9 p.m. Sunset Concert, New Era Events Plaza The Way Down...
Christian Gonzalez Could Force Patriots Into Awkward Training Camp Standoff
There are no official deadlines in late June or early July in the National Football League. In New England, though, all eyes remain on the Christian Gonzalez contract situation and whether or not he becomes the next young, budding defensive superstar to be rewarded with a mega-deal. Gonzalez, the team’s first-round pick in 2023, has one Pro Bowl and one monster playoff run that has people talking about him like he's an elite corner.
Christina "Ms. Basketball" Granville has the latest in entertainment headlines
Music mogul Clive Davis passed away, we find out more about Jay-Z's loc journey. And Christina is gearing up for her free all girls basketball camp.
Kindness Is the Science
A neuroscientist and a contemplative teacher make an empirical case for flourishing.
Business Must Prepare Now for Mandatory E-Invoicing Challenges
Opinion: As mandatory e-invoicing spreads worldwide, businesses need to build flexible, central compliance architectures that can scale globally rather than react to each new mandate individually, say RSM practitioners Philip Munn and Christian Balk.
Learn Science with Dr. V: Does your weight change with location?
How much do you weigh in Ruidoso? Do you think you would weigh the same in places like Corpus Christi or Galveston, which are at sea level?