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The DJI Avata 360 Aims to Ground Insta360's Drone Dreams

With a better camera, more advanced sensors, and more versatility, DJI is clearly aiming to take down Insta360’s Antigravity.

Mar 26 • 8:00 AM EDT • Technology • petapixel.com

Apple Testing 200MP iPhone Camera That Could Ship Next Year

Apple is evaluating a 200-megapixel telephoto camera sensor that could potentially ship in an iPhone as soon as next year, according to Digital Chat Station, a leaker on Chinese social media platform Weibo with a decent track record. In a post shared today, the leaker said Apple is actively testing a 200-megapixel 1/1.2" sensor similar to the one rumored for Oppo's upcoming Find X9 Ultra.

Mar 26 • 7:04 AM EDT • Technology • macrumors.com

How a Healthy Mind-Set Influences Longevity

A few qualities, including a sense of purpose, seem to have real benefits — especially as you age.

Mar 26 • 5:00 AM EDT • Health • nytimes.com

Trump showed off a classified map during a 2022 plane trip, Raskin alleges in letter

President Donald Trump showed off a classified map on a 2022 flight to his New Jersey golf club and held onto a record from his first term that was so sensitive only six people would have had access to it, according to a letter released Wednesday by a top House Democrat.

Mar 25 • 4:18 PM EDT • Politics • pbs.org

Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com

Smith memo: Trump had classified docs shared with just 6 people, others tied to his business interests

Among the classified records taken to Mar-a-Lago by President Trump were documents so sensitive that one had been distributed to just six people, while another set was relevant to his business inte…

Mar 25 • 5:00 AM EDT • Business • thehill.com

Bioresorbable microneedles track organ health

Nature Reviews Bioengineering - An article in Nature Biomedical Engineering reports a bioresorbable flexible microneedle sensor array for continuous monitoring of organ function for at least 7...

Mar 24 • 8:00 PM EDT • Health • nature.com

Highly and casually active citizen scientists contribute equally valuable data

The word "nemotia" is a neologism, a newly coined term that in this case, describes the sense of overwhelmingness and disconnect accompanying the thought that nothing you do will ever make a difference. ...

Mar 24 • 5:40 PM EDT • Science • phys.org

ICE presence rising at Michigan health care facilities, rights groups say

The Michigan Immigrant Rights Center and the ACLU of Michigan have sent guidance to more than 400 hospitals and providers in the state to outline law enforcement changes to ‘sensitive locations’ policy.

Mar 24 • 5:04 PM EDT • Health • bridgemi.com

Drought could fuel the rise of antibiotic-resistant superbugs as climate change worsens, new research suggests

A warming world may see more antibiotic-resistant bacteria, according to new research that shows a link between aridity and antibiotic resistance today.

Mar 24 • 5:02 PM EDT • Science • livescience.com

Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com

Senators consider deal to fund Homeland Security but not ICE enforcement

WASHINGTON (AP) — Senators raced Tuesday to clinch an emerging proposal to end the Homeland Security shutdown by funding much of the department, including the Transportation Security Administration airport workers going without pay, but excluding the ICE enforcement operations that have been core to the dispute. The sudden sense of urgency comes as U.S. airports […]

Mar 24 • 12:25 PM EDT • Politics • coloradopolitics.com

World Athletics Expands Air Quality Monitoring, But Can Sports Fill Global South’s Data Void?

The walk coordinators carried portable air quality sensors, logging particulate matter (PM)2.5 (fine particles) and PM10 (coarse particles), nitrogen dioxide

Mar 24 • 9:50 AM EDT • Sports • healthpolicy-watch.news

Differences between W2 and 1099 workers for small businesses

Hiring for your small business? One of the first decisions you’ll face is who to hire and how to classify them. Should you bring on a W-2 employee or a 1099 independent contractor? In this episode of Small Business Smarts, ADP’s Laci Buzzelli breaks down the key differences between the two and when each option makes the most sense for small businesses. For more information, visit ADP.com/SPARK

Mar 24 • 8:02 AM EDT • Business • mediacenter.adp.com

On the road with antiprotons: CERN runs delicate test on transporting ultrasensitive antimatter

Scientists at CERN plan to take some antiprotons out for a spin in a never-tried-before test drive.

Mar 24 • 1:52 AM EDT • Science • seattletimes.com

Scientists take antimatter on first road trip as they study how to transport ultra-sensitive cargo

Scientists at CERN are taking some antiprotons out for a spin in a never-tried-before test drive.

Mar 24 • 1:48 AM EDT • Science • ksat.com

On the Road With Antiprotons: CERN Runs Delicate Test on Transporting Ultrasensitive Antimatter

GENEVA (AP) — Scientists in Geneva are taking some antiprotons out for a spin — a very delicate one — in a truck, in a never-tried-before test drive. If this so-called antimatter comes into contact with actual matter — even for a fraction of an instant — it will be annihilated in a quick flash of ...

Mar 24 • 1:48 AM EDT • Science • usnews.com

The MacBook Neo proves Apple is leaving a door wide open for Google’s ‘Aluminium OS’

Apple recently did something that, on paper, seems to make no sense. They launched the MacBook Neo; a $599 laptop powered by the A18 Pro chip that, in a previous life, powered the iPhone 16 series....

Mar 23 • 12:35 PM EDT • Technology • chromeunboxed.com

Cowboys mock draft tracker: A trade might make sense early

How interested are you in trading back in the first round?

Mar 23 • 9:00 AM EDT • Sports • sports.yahoo.com

Letters: Newspapers hold a position in our democracy, unlike any other business

I read with interest Duke Truby's viewpoint about a newspaper print medium being a "business" in the strictest sense. As such, that business should cater to its customers and clients.

Mar 23 • 1:30 AM EDT • Business • nola.com

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com

VoidStealer malware steals Chrome master key via debugger trick

An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.

Mar 22 • 10:32 AM EDT • Technology • bleepingcomputer.com

G.O.P. Bid to Target Transgender Athletes Falls Flat in the Senate

In moving to bar transgender women and girls from women’s and girls’ sports, Republicans sought to put Democrats in an awkward political spot on a sensitive issue ahead of the midterm elections.

Mar 21 • 4:56 PM EDT • Politics • nytimes.com

Robert Mueller, and Trump’s many insensitive comments about people who died

For years, President Donald Trump has offered crass and insensitive comments about people who died – especially his foes. That reached a new level on Saturday.

Mar 21 • 4:53 PM EDT • Politics • cnn.com

iOS 26.4: Top 10 New Features Coming to Your iPhone

iOS 26.4 isn't the major update with new Siri features that we hoped for, but there are some useful quality of life improvements, and a little bit of fun with an AI playlist generator and new emoji characters. Playlist Playground - Apple Music has a Playlist Playground option that lets you generate playlists from text-based descriptions. You can include moods, feelings, activities, or make up something entirely nonsensical and let the AI figure out what you mean.

Mar 20 • 5:44 PM EDT • Technology • macrumors.com

New Business Licenses: 3.20.26

Chesterfield reports several new construction and contracting firms, including a custom garage builder. (BizSense Pro required)

Mar 20 • 2:00 AM EDT • Business • richmondbizsense.com

Anthropic just shipped an OpenClaw killer called Claude Code Channels, letting you message it over Telegram and Discord

The consensus among early adopters is that Anthropic has successfully internalized the most desirable features of the open-source movement—multi-channel support and long-term memory

Mar 19 • 9:51 PM EDT • Technology • venturebeat.com

Sense of belonging predicts who stays in science

New research shows that feeling connected to a scientific community may be key to reducing attrition, with professional societies positioned to strengthen belonging across disciplines.

Mar 19 • 7:01 PM EDT • Science • news.vt.edu

New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

Mar 19 • 5:28 PM EDT • Technology • gamefile.news

Our Universe Has Hidden Dimensions, Scientist Claims—And They’re Close Enough to Touch

The true nature of reality might be lurking just beyond our senses, according to this theory.

Mar 19 • 4:14 PM EDT • Science • popularmechanics.com

Arts and Entertainment Agenda: March 20-27

Consensual Improv, March 20 Roaring Fork Valley’s one-and-only improv comedy troupe is back. Consensual Improv will be hosting an upcoming show at 8 p.m. March 20 at The Arts Campus at Willits. Since 2016, they...

Mar 19 • 1:37 PM EDT • Entertainment • aspentimes.com

New ‘Perseus’ Android malware checks user notes for secrets

A new Android malware called Perseus is checking user-curated notes to steal sensitive information, like passwords, recovery phrases, or financial data.

Mar 19 • 6:13 AM EDT • Technology • bleepingcomputer.com

Leading Chinese remote-sensing scientist Zhang Jinshui dies at 47

Beijing Normal professor led major R&D programmes and was instrumental in enhancing the country’s food security with satellite technologies.

Mar 19 • 2:00 AM EDT • Science • scmp.com

Olympics urged to drop reported gender test plans for female athletes

Global sports leaders ‌reached consensus on a new set of eligibility criteria for transgender athletes in February.

Mar 18 • 7:41 AM EDT • Sports • aljazeera.com

Odafe Oweh says picking the Commanders 'made the most sense'

Odafe Oweh says picking the Commanders "made the most sense."

Mar 18 • 5:31 AM EDT • Sports • sports.yahoo.com

FNKO Q4 Deep Dive: Entertainment Slate and International Initiatives Guide 2026 Outlook

Pop culture collectibles manufacturer Funko (NASDAQ:FNKO) reported Q4 CY2025 results topping the market’s revenue expectations, but sales fell by 7% year on year to $273.1 million. Its non-GAAP profit of $0.05 per share was $0.02 above analysts’ consensus estimates.

Mar 17 • 2:12 PM EDT • Entertainment • finance.yahoo.com

President of Summa Health Medical Group pleads guilty in revenge porn case, avoids prison

The President of Summa Health Medical Group pleaded guilty to one count of nonconsensual dissemination of private sexual images in connection with a revenge porn investigation.

Mar 17 • 9:01 AM EDT • Health • cleveland19.com

Alibaba shakeup hints at an AI business model

The $325 bln group ‌is separating its AI initiatives from its cloud computing unit. It’s a nod to a craze for digital agents like OpenClaw and willingness of consumers to pay for these standalone services. Monetising AI will remain daunting but the rejig makes sense.

Mar 17 • 12:58 AM EDT • Business • reuters.com

UPMC warns embattled data exchange Health Gorilla may have improperly pulled patient records

UPMC says its medical records may have been improperly accessed by Health Gorilla, a patient data gatekeeper accused in federal court of mismanaging sensitive information. Health Gorilla requested data “under the pretext of providing treatment to shared UPMC patients and claimed it had permission to do so,” according to a

Mar 16 • 2:16 PM EDT • Health • triblive.com

Farage Mega Donor Exposes Vulnerability in UK Politics

Britain’s biggest political donor is a crypto investor and aviation entrepreneur who has lived in Thailand for more than two decades. The £12 million ($16 million) that Christopher Harborne gave to Nigel Farage’s Reform UK last year wouldn’t be permitted in France, Canada or Ireland. If you’re sensing something askew with the UK’s rules for campaign finance contributions, you’re not alone.

Mar 16 • 1:00 AM EDT • Politics • bloomberg.com

Cells can sense 10x farther than expected and it may explain cancer spread

Scientists have discovered that cells can sense far beyond the surfaces they touch. While individual cancer cells can probe about 10 microns ahead by tugging on surrounding collagen fibers, clusters of normal epithelial cells can combine forces to detect layers as far as 100 microns away. This long-range “depth sensing” helps cells decide where to migrate. Understanding how it works could reveal new targets to stop cancer from spreading.

Mar 15 • 8:00 PM EDT • Science • sciencedaily.com

iOS 27 Will Reportedly Be Like Mac OS X Snow Leopard

In his Power On newsletter today, Bloomberg's Mark Gurman reiterated that iOS 27 will be similar to 2009's Mac OS X Snow Leopard, in the sense that one of Apple's biggest priorities is bug fixes for improved performance and stability. At WWDC 2008, Apple showed a presentation that said Mac OS X Snow Leopard had "0 new features," as it opted to focus on performance and stability improvements.

Mar 15 • 12:42 PM EDT • Technology • macrumors.com

Marines are looking for a cloak to hide from thermal-imaging drones

Marines are on the hunt for a cloak to hide from thermal-imaging sensors

Mar 14 • 10:56 AM EDT • Business • businessinsider.com

Canon EOS R7 Mark II Info: 39MP Stacked Sensor and 2026 Release Date

The wait for the Canon EOS R7 Mark II is almost over. A new report suggest a big sensor upgrade to a 39MP BSI Stacked sensor—a first for Canon APS-C. Here is what we know about the mid-2026 launch.

Mar 14 • 9:33 AM EDT • Technology • canonrumors.com

Linux Finally Catches Up to Windows with a Game-Changing Performance Feature

For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.

Mar 14 • 8:00 AM EDT • Technology • iowaparkleader.com

Make It Make Sense: What needs to happen for oil & gas prices to drop?

Mar 12 • 1:20 PM EDT • Business • cnn.com

We May Not Be Limited to the Senses We’re Born With, Expert Claims. This Hidden Superpower Is Proof.

Researchers are already helping people hone this sixth sense.

Mar 12 • 12:52 PM EDT • Science • popularmechanics.com

Several California DAs Call On Legislature to Fix the Mental Health Diversion Law With AB 46 | Riverside County District Attorney

RIVERSIDE – The Riverside District Attorney’s Office is joining the California District Attorneys Association in their statewide call for the California Legislature to pass common sense mental health diversion (MHD) legislation, Assembly Bill 46.

Mar 12 • 8:00 AM EDT • Health • rivcoda.org

Dr. Scolese speaks at AAS Goddard Space Science Symposium; discusses a

The National Reconnaissance Office is working to advance cutting-edge technologies, including artificial intelligence and quantum sensing, to better meet the demands of its customers, NRO Director

Mar 11 • 8:00 PM EDT • Science • nro.gov

Biomolecular profiling for noninvasive health monitoring

Nature Biotechnology - Kim et al. present mass spectrometry and wearable sensor technology as complementary approaches that, when integrated, can co-evolve to open new possibilities for noninvasive...

Mar 11 • 8:00 PM EDT • Health • nature.com

2026 William T. Pecora Award Nominations Now Being Accepted

The William T. Pecora Award is presented annually to individuals or teams using satellite or aerial remote sensing that make outstanding contributions toward understanding the Earth (land, oceans, and air), educating the next generation of scientists, informing decision-makers, or supporting natural or human-induced disaster response. Both national and international nominations are welcome.

Mar 11 • 4:18 PM EDT • Science • science.nasa.gov

Trump’s revolutionary sense of time is changing politics

The US president doesn’t think in terms of long-term strategy but rather in terms of deadlines

Mar 11 • 11:33 AM EDT • Politics • ft.com

Laying the Foundations for an Americas Mental Health Policy Innovation Hub | Johns Hopkins Center for Global Mental Health

The project “Laying the Foundations for an Americas Mental Health Policy Innovation Hub,” led by Dr. María Cecilia Dedios and colleagues at the Johns Hopkins Center for Global Mental Health, aims to establish a regional platform that connects academics, policymakers, and civil society to advance collaborative mental health policymaking across the Americas. The initiative focuses on strengthening intersectoral approaches to population mental health and embedding meaningful community participation and lived experience into policy processes. Through a pilot consensus-building effort with decision-makers in Bogotá, Colombia, the project has begun testing methods for cross-sector collaboration to address shared priorities such as loneliness and underage substance use. Ultimately, the Hub seeks to foster regional learning and develop more participatory, coordinated, and socially responsive mental health policies.

Mar 11 • 8:00 AM EDT • Health • publichealth.jhu.edu

Why Site Preparation Makes Sense as Public Investment

Funding for site preparation can support improvements that make Michigan's best business locations more attractive and draw investment and jobs to our state.

Mar 11 • 8:00 AM EDT • Business • michiganbusiness.org

Medical Debt Associated with Deferring Dental, Medical, and Mental Health Care | Johns Hopkins Bloomberg School of Public Health

Deferred care due to medical debt consistently high across all types of insurance, with dental care the most sensitive to medical debt.

Mar 11 • 8:00 AM EDT • Health • publichealth.jhu.edu

Concrete sensor manufacturer Wavelogix receives $500K grant from National Science Foundation

WEST LAFAYETTE, Ind. — Wavelogix, a manufacturer of novel, patented concrete strength sensors invented at Purdue University’s College of Engineering, has received a $500,000…

Mar 11 • 7:38 AM EDT • Science • purdue.edu

House Republicans confront Iran war and gas prices as they struggle to push economic agenda

Speaker Mike Johnson and his leadership team have been struggling to find consensus behind an election-year agenda to address Americans’ chief concerns over affordability and their cost-of-living.

Mar 11 • 6:00 AM EDT • Politics • cnn.com

Haleon Strengthens Commitment to China as Consumers Focus on Better Everyday Health

SHANGHAI, March 11, 2026--Haleon, a consumer company that is solely focused on better everyday health, is investing £65 million in a new state-of-the-art oral health manufacturing site in Shanghai. The facility will support the expansion of its oral care portfolio – which includes the global brands Sensodyne and parodontax – into China’s fast-growing tier 2 and tier 3 cities, where rising incomes, growing awareness of everyday health and a shift towards trusted, branded products are reshaping co

Mar 11 • 5:00 AM EDT • Health • finance.yahoo.com

Georgia Independent Wrestling’s Empire of Entertainment

“I remember just standing there that night, and I could feel this connection between the fans and the performers in a way that I hadn’t really ever felt before, which makes sense now that I know more about wrestling, because fans really have agency over the action in the ring. The louder they cheer, the more the wrestler is going to labor to his feet. Wrestling doesn’t really work without an audience,” says Athens journalist Alison Lyn Miller, who published the nonfiction book Rough House: A Father, a Son, and the Pursuit of Pro Wrestling Glory earlier this year. Miller wasn’t a wrestling fan when she attended the now-defunct Southern Violence And Wrestling match back in 2019, but her passion […]

Mar 11 • 12:30 AM EDT • Entertainment • flagpole.com

Whistleblower claims ex-DOGE member says he took Social Security data to new job

The Social Security inspector general’s office is investigating allegations that the former DOGE engineer took sensitive data on a thumb drive in a major potential security breach, said people familiar with the process.

Mar 10 • 10:47 PM EDT • Politics • washingtonpost.com

Do Middle-earth and Westeros make sense? Climate scientists modelled them to find out

It’s a seemingly whimsical exercise, but it serves serious purposes.

Mar 10 • 9:31 PM EDT • Science • theconversation.com

Smart Plants in a Changing World Science

The Salk Institute is teaming up with the Del Mar Foundation for a three-part webinar series to highlight Salk's foundational research in brain health, cancer, and agriculture. Join us on Wednesday, March 11, at 10 a.m. to learn directly from Salk scientist Lucia Strader about how plants sense and respond to their environments, and how understanding these natural survival strategies can help us develop crops that thrive in a changing world. The Del Mar Foundation is offering a 1:1 Challenge Match through June. Gifts made during the webinar series will be matched dollar-for-dollar, doubling your impact on critical research. Donors who give $1,000 or more to an area of greatest need will also join the Discovery Society, with special access to Salk news and events. Salk Institute on Facebook / Instagram

Mar 10 • 8:00 PM EDT • Science • kpbs.org

Critical Microsoft Excel bug weaponizes Copilot Agent for zero-click information disclosure attack

: Could steal sensitive personal and financial data

Mar 10 • 4:35 PM EDT • Technology • theregister.com

Watertown business owner speaks out about knife threat

“I’m no hero. I was just protecting the kids.” That’s what the owner of a Watertown dance studio is saying about being threatened with a knife near her business.

Mar 10 • 2:08 PM EDT • Business • wwnytv.com

JFK Jr.'s cousin speaks out on Daryl Hannah's 'Love Story' portrayal after actress' scathing essay

Douglas Kennedy defends Daryl Hannah after the Grammy-nominated actress called out Ryan Murphy's 'Love Story' for her portrayal in the FX series: 'I think that's a misrepresentation.'

Mar 9 • 11:23 AM EDT • Entertainment • ew.com

The Mystery Black Sensor Pogačar Wore at Strade Bianche Might Not Be What You Think It Is

Pogačar kicked up a storm of speculation about the bicep sensor he wore at Strade Bianche. We found out what it actually is.

Mar 8 • 3:10 AM EDT • Technology • velo.outsideonline.com

Quantum breakthrough: China’s double-photon device breaks efficiency ceiling

Chinese innovation can pave the way for sharper medical imaging, unbreakable encryption and next-gen sensors.

Mar 8 • 1:30 AM EST • Science • scmp.com

Summer of the Arts reveals 2026 free program lineup

Enjoy free entertainment all summer with the 2026 Friday Night Concert Series and Drive-in Movies at the Hangar. The programs foster a sense of community through music and film in Iowa City.

Mar 7 • 7:00 AM EST • Entertainment • thegazette.com

How The Investment Story Is Shifting For Phibro Animal Health (PAHC) After Fresh Analyst Targets

Analysts have lifted their price target on Phibro Animal Health by $4, while the model fair value remains at $48.50. That gap reflects a refreshed research view, with some seeing a more attractive balance between risk and reward and others still highlighting execution and valuation sensitivity as key watchpoints. As you read on, you will see how this evolving narrative might shape your own thinking on the stock over time. Stay updated as the Fair Value for Phibro Animal Health shifts by...

Mar 7 • 6:08 AM EST • Health • finance.yahoo.com

Chido Obi: Man United starlet’s sensational form awarded with nomination

Manchester United have had several key players in form at youth level this season.Positive season for youthThe Under-18s booked their place in the final of the Premier League Cup with a 3-1 win over W...

Mar 7 • 2:40 AM EST • Sports • sports.yahoo.com

Entertainment over substance

As consumerism and technology continue to rise and root themselves globally, the matter of finding meaning through the endless amounts of hollow entertainment becomes an even more significant issue. Social media, sensationalism, and reality shows have been taking over society for the last few decades, creating an era where individuals are constantly looking to be...

Mar 6 • 1:00 PM EST • Entertainment • loyolamaroon.com

This Ultra phone is the first to use Sony's brand-new 200MP camera sensor

The upcoming Vivo X300 Ultra will be the first to use Sony's 1/1.12-inch, 200-megapixel LYTIA 901 camera sensor.

Mar 5 • 4:41 PM EST • Technology • androidauthority.com

American basketball player Jarred Shaw hoping for 'miracle' in Indonesian prison as health crisis worsens

American basketball player Jarred Shaw faces a health crisis while in an Indonesian prison after his May 2025 cannabis arrest, with the former star battling Crohn's disease.

Mar 5 • 3:21 PM EST • Health • foxnews.com

3L Kevin Afiesh Learns to Translate Legal Risk Into Business Strategy as FinTech Extern  - UC Law San Francisco (Formerly UC Hastings)

3L Kevin Afiesh strengthened his corporate and fintech skillset through an externship at Plaid, gaining real-world experience at the intersection of technology and financial services. 3L student Kevin Afiesh shares how UC Law San Francisco’s Corporate Counsel Externship provided immersive, practice-ready training inside Plaid’s in-house legal department. Reviewed and analyzed technology-focused agreements, including emerging AI provisions and liability terms Explored financial services regulation and data governance within a growth-stage company Learned how internal legal teams shape product, partnership, and compliance planning 3L student Kevin Afiesh: During my externship at Plaid, I worked with the in-house legal team supporting a rapidly growing company at the intersection of technology and financial services. My work focused primarily on corporate, commercial, and intellectual property matters. I helped review and analyze vendor and partnership agreements, paying close attention to emerging artificial intelligence-related provisions and risk allocation terms. I also investigated regulatory and compliance issues involving financial services and data governance, and I researched intellectual property litigation relevant to fintech companies. This work supported legal risk assessment to guide strategic decision making. I learned firsthand how an in-house legal team operates in a highly regulated, innovation-driven environment, where legal analysis is closely integrated with business decision making. I saw how attorneys balance legal risk with commercial priorities and how their advice shapes contracting, compliance, and intellectual property strategy. It reinforced that effective in-house lawyers need to understand both the law and the operational realities of the business. The experience also strengthened my ability to communicate complex legal concepts clearly to non-lawyers and to provide advice that is precise, practical, and commercially aware. Throughout my academic and professional journey, I’ve worked with technology companies at different stages. Plaid added a distinct perspective within the tech ecosystem, showing me how a growth-stage fintech company approaches regulatory complexity, innovation, and risk tolerance. This sharpened my ability to adapt to clients with different structures, priorities, and compliance needs. As I prepare to practice corporate law in the technology industry, this exposure has strengthened my ability to align legal advice with a company’s stage of growth, strategic objectives, and internal dynamics. I would absolutely recommend the Corporate Counsel Externship Program. Working directly with an in-house legal team provided a meaningful sense of day-to-day practice inside a technology company, and the attorneys at Plaid were generous with their time and mentorship. The classroom component was equally valuable. Professors Nira Geevargis and Scott Darling created a thoughtful environment where we reflected on our experiences, discussed real-world challenges, and developed practical skills that complemented our fieldwork. More broadly, UC Law San Francisco’s location offers a clear advantage for students interested in technology, corporate practice, and public-interest work. Proximity to courts, law firms, and innovative companies — combined with programs like the Corporate Counsel Externship and an extensive Bay Area alumni network — make it a strong option for students who want to build their careers in the region. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.

Mar 5 • 11:00 AM EST • Business • uclawsf.edu

CNBC Sport: Paramount may unwind WBD's sports strategy if merger goes through

WBD's sports strategy it has deployed since it lost NBA rights may not make sense if it's acquired by Paramount.

Mar 5 • 10:06 AM EST • Sports • cnbc.com

Scientists discover a hidden force that helps wire the brain

Growing neurons rely on chemical cues to find their targets, but new research shows that the brain’s physical properties help shape those signals. Scientists discovered that tissue stiffness can trigger the production of guidance molecules through a force-sensing protein called Piezo1. This protein not only detects mechanical forces but also helps maintain the structure of brain tissue. The discovery reveals a powerful link between the brain’s physical environment and how its wiring is built.

Mar 5 • 7:00 AM EST • Science • sciencedaily.com

Iran’s succession question: Rouhani’s name resurfaces amid leadership void

Rouhani's legacy of pragmatism and moderation gains renewed relevance amid Iran's sensitive leadership transition phase.

Mar 4 • 9:58 PM EST • Politics • aljazeera.com

Bipartisan bill requiring annual mental health screenings by Oklahoma providers advances

The policy seeks to help detect symptoms early and connect patients to care before their mental health condition worsens and treatment becomes more costly.

Mar 4 • 6:23 AM EST • Health • kosu.org

What your Meta smart glasses record doesn’t stay on your smart glasses, ‘data labeling’ contractors say

Meta contractors say they’ve been tasked with reviewing highly sensitive videos captured by the company’s smart glasses.

Mar 3 • 5:28 PM EST • Technology • san.com

Meta's AI display glasses reportedly share intimate videos with human moderators

Users in Europe of Meta's AI smart glasses may be unknowingly sharing intimate video and sensitive financial information with moderators outside of the bloc.

Mar 3 • 8:59 AM EST • Technology • engadget.com

Stressed out by politics? You’re not imagining it, and research shows that social media is largely to blame

Political content on social media finds you even if you’re not looking for it, and it tends to do so through a sensationalized and emotionally charged lens.

Mar 3 • 8:38 AM EST • Politics • theconversation.com

Meta Ray-Bans send 'sensitive' videos to human data annotators

A new report says that video feeds from Meta Ray-Ban smart glasses are sent for review by human data annotators...

Mar 3 • 7:19 AM EST • Technology • 9to5mac.com

Scientists find the genetic switch that makes pancreatic cancer resist chemotherapy

Scientists have identified a crucial molecular switch that decides whether pancreatic cancer cells resist chemotherapy or respond to it. The key player, a gene called GATA6, keeps tumours in a more structured and treatable form—but it gets shut down by an overactive KRAS-driven pathway. When researchers blocked that pathway, GATA6 levels rebounded and cancer cells became more sensitive to chemo. The discovery could help turn some of the toughest pancreatic tumours into ones doctors can better control.

Mar 3 • 7:00 AM EST • Science • sciencedaily.com

The hidden technology that could unlock commercial fusion power

Fusion energy may be one of the most promising clean power sources of the future—but only if scientists can precisely measure the extreme, fast-moving plasmas that make it possible. A new U.S. Department of Energy–sponsored report urges major investment in advanced diagnostic tools—the high-tech “sensors” that track plasma temperature, density, and behavior inside fusion systems. Bringing together 70 experts from universities, national labs, and private industry, the workshop identified seven priority areas ranging from burning plasma to full-scale pilot plants.

Mar 3 • 7:00 AM EST • Science • sciencedaily.com

Zendaya and Tom Holland are married, her stylist casually reveals

Zendaya's stylist Law Roach says Tom Holland and the 'Euphoria' star are married already, and the whole world missed the wedding. So much for our Spidey sense?

Mar 2 • 1:55 PM EST • Entertainment • latimes.com

Early Galaxy S27 Ultra rumor says Samsung might finally upgrade its main 200MP sensor

Samsung might be working on a big upgrade for the Galaxy S27 Ultra's camera, even as we wait for the S26 Ultra to hit store shelves.

Mar 2 • 11:10 AM EST • Technology • 9to5google.com

NASA’s ER-2 Aircraft Captures Moonlight to Calibrate Space Sensors

A NASA instrument designed to measure moonlight to help satellite sensors make more accurate measurements.

Mar 2 • 9:02 AM EST • Science • science.nasa.gov

Motorola's Edge 70 Fusion phone has a huge curved 144Hz display

Motorola has unveiled the Edge 70 Fusion, its latest mid-range model with an impressive display and OIS-enabled camera with a Sony sensor.

Mar 2 • 4:30 AM EST • Technology • engadget.com

Scientists just turned light into a remote control for crystals

NYU researchers have found a way to use light to control how microscopic particles assemble into crystals, effectively turning illumination into a tool for shaping matter. By adding light-sensitive molecules to a liquid filled with tiny particles, they can adjust how strongly the particles attract or repel one another simply by changing the light’s intensity or pattern. This allows them to trigger crystals to form, dissolve, or even be reshaped in real time.

Mar 1 • 7:00 PM EST • Science • sciencedaily.com

Women Experience Longer Lasting Pain Than Men and Scientists Think They Finally Know the Reason Why

New study links testosterone-tuned monocytes to an anti-pain signal after injury.

Mar 1 • 12:58 PM EST • Science • zmescience.com