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As Trump feels pressure to end war, allies fear what Iran may do next
Iran has demonstrated it can inflict significant damage on the world’s economy, even while outgunned. That creates a dilemma for President Trump.
As political pressure mounts, medical school accreditor drops requirement to teach about health equity
The leading medical school accreditation body in the U.S. has removed language from its standards requiring schools to teach about health inequities
AAP faces pressure over trans youth care, guiding docs to keep parents in the dark about child's sexual health
A parental rights group accused the AAP of hiding minors' sexual health info from parents and pushing transgender procedures over parental concerns.
Bikes Keep Honda Afloat Yet Even That Business Is Under Pressure
Honda Motor Co.’s costly misfire on electric cars has dramatically increased the stakes for the company to avoid making the same mistakes with motorcycles.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Upset winner Gray Davis on California's last wide-open governor's race
Gray Davis was a huge underdog who prevailed in a wide-open 1998 contest. The Democrat urges trailing hopefuls to ignore pressure to quit and 'follow your heart.'
Hubert Davis out as UNC coach after five years, ushering in historic break from Carolina family tradition
A stunning NCAA Tournament collapse, eroding donor support and mounting internal pressure culminated in North Carolina cutting ties, a move that breaks the program's 70-year coaching lineage
Victor Wembanyama, surging Spurs face depleted Grizzlies
The San Antonio Spurs are building momentum as the season winds down, a push that is putting pressure on Western Conference leader Oklahoma City.
GOP candidates lead in CADEM-commissioned gubernatorial poll
This extraordinary pressure campaign is only just beginning
Veteran prosecutor confirmed to lead new Justice Department division targeting fraud nationwide
The Senate has confirmed President Donald Trump’s pick to lead a new Justice Department division focused on prosecuting fraud over critics’ concerns of potential political pressure to target White House opponents
Investors Question Whether Quick Peace in Iran Is Possible
Global markets are under pressure again amid doubts that the fighting in the Middle East can end anytime soon.
Opinion | Why Are So Many Democrats So Far Out of Touch?
Candidates in safe districts are under no pressure to moderate in order to win.
UCI Health lays off 150 workers as part of restructuring
UCI Health said the cuts were prompted by a changing environment that includes shifts in federal funding, reimbursement pressures and rising operational costs,
A surprising foam discovery could change everyday products
Foams have long baffled scientists because liquid drains from them far sooner than theory predicts. New research shows the reason: the bubbles don’t stay put—they rearrange, opening pathways for liquid to escape. The key factor is the pressure needed to shift bubbles, not just push liquid through them. This insight reshapes how we understand foams and could improve everyday products.
Companies Aren’t Ripping Out Business Software for AI. Here’s What They’re Doing Instead.
Tech leaders at large corporations say that, for now, they’re vibe-coding their own small, custom apps, and putting pressure on their software vendors.
Crimson Desert now launches on Intel Arc, Pearl Abyss changes course
Pressure matters: Crimson Desert now boots on Intel Arc, full optimization still pending Pearl Abyss has changed its position on Intel Arc support in
Fertilizer prices bring more pain for American farmers amid war in Iran
The war in Iran is pushing up prices for already-strained farmers, with higher costs for fertilizer and energy on top of last year’s tariffs. And the increasing pressure on American agriculture could lead to even bigger price tags at the grocery store.
Bitsight SPM launched to connect cyber risk with business outcomes as pressure to prove resilience grows
Bitsight launches Bitsight SPM to connect cyber risk with business outcomes as pressure to prove resilience grows.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Oil prices face new pressure as US and Iran trade threats
Trump said the US would attack Iran's power plants if it didn't reopen the Strait of Hormuz in 48 hours. Iran responded on Sunday with is own threats.
Cuba Says Its Military Is Prepared as Trump’s Threats Multiply
A senior Cuban official said the country is preparing for a possible military assault as President Donald Trump increases economic pressure on the government in Havana and suggests it could be the next US target after Venezuela and Iran.
Scientists discover surprising brain trigger behind high blood pressure
Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.
Fed’s Powell Lauds Volcker Record in Face of Political Pressure
Federal Reserve Chair Jerome Powell on Saturday lauded the policy record of the late Fed Chair Paul Volcker, who raised interest rates and sparked a recession to tame the high inflation that took off during the 1970s.
Hubert Davis' future at North Carolina in serious doubt as pressure mounts after historic collapse
Sources tell CBS Sports that Hubert Davis' future at North Carolina is in serious doubt after a historic NCAA Tournament collapse, with boosters losing faith and questioning their willingness to fund the program.
Ancient DNA reveals a farming shift that pushed a society to the brink
A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.
6 Supplements That May Support Heart Health
Supplements that may support heart health include garlic, fiber, and red yeast rice. They may lower cholesterol levels and improve blood pressure.
Steelers await Aaron Rodgers decision as NFL draft nears
Ben Roethlisberger weighs in as uncertainty surrounds Pittsburgh’s QB plan, with new weapons adding pressure for clarity before the 2026 NFL Draft.
Companies are spending more on AI—HR leaders question the payoff
HR executives say AI adoption is driving up costs, placing pressure on productivity gains and long-term profitability.
9% of ACA enrollees go uninsured after enhanced subsidies expire, poll finds
Many Americans face financial pressures after Affordable Care Act enhanced premium subsidies expired at the end of 2025.
Norway’s Improving Business Outlook in Survey Dents Easing Bets
A key survey of Norway’s business sentiment signaled somewhat better prospects for the nation’s companies, suggesting less pressure on the central bank to consider any easing moves in the near term.
Under Trump, the government’s watchdogs are losing their independence
Inspectors general are subject to growing partisan pressures as the White House and political figures seek greater influence over them than ever before.
Blue Jackets bring pressure-based mindset into meeting with Rangers
The Columbus Blue Jackets are on a 10-game point streak (6-0-4) as they prepare to host the New York Rangers on Thursday night.
UC-created algorithm can help treat chronic health condition
High blood pressure affects about half of U.S. adults.
Looking for leverage: China keeps close eye on US politics after summit delay
Beijing seeks to decipher effect of Iran war on US midterms and best way to apply pressure when Trump meets Xi
Illinois businesses shift into growth mode after strong 2025
Local companies are confident after surviving years of high interest rates, inflationary pressure and tariff uncertainty, says a new BMO outlook.
What is happening in Cuba? Economic struggles, US tensions explained
Trump has recently increased pressure on the island nation of Cuba, adding March 17 Washington would be doing "something with Cuba" soon.
The media’s year of ‘change or die’
The media and entertainment industries face a period of great turmoil, including unprecedented business and political pressures. Evan Shapiro, the so-called “Media Universe Cartographer,” speaks to Geoff Bennett about those challenges and the future.
Dante Moore reveals mental health struggles, asks Oregon governor for more state resources
In a letter to Oregon's governor, Moore cited the pressure thrust upon him as an 18-year-old freshman starting quarterback at UCLA in 2023.
Pressure grows to postpone king’s state visit to US amid Iran war and Trump’s jibes at allies
Emily Thornberry is the latest figure to call on the king’s visit to the US to be delayed, citing the ongoing war against Iran
White House digs in on ‘most-favored nation’ drug pricing despite Congress’ cool reception
Despite a cool reception from Congress, the White House is looking to intensify its pressure campaign on lawmakers to pass a “most-favored nation" drug pricing bill.
National Academies of Sciences resisting pressure to pull climate info
State attorneys general won't get climate chapter removed from a legal manual.
Oregon QB Dante Moore reveals struggles with mental health
Oregon quarterback Dante Moore has revealed he struggled with mental health issues associated with the pressures of major college football.
Trump is presented daily with options to end the war in Iran. He hasn't taken any so far.
The off-ramps are a standard part of war planning, which also includes possibilities for escalation if the White House decides to increase the pressure on Iran, sources tell NBC News.
Trump suggests he may delay China trip due to Iran war, but Bessent says it's not to pressure on Strait of Hormuz
Bessent downplays rising oil prices and says the Treasury Department doesn't plan to intervene.
No H.I.V. Aid Without More Access to Minerals: U.S. Ponders ‘Sticks’ Against Zambia
A draft State Department memo outlines ways the Trump administration may ratchet up pressure on the African country by ending health support “on a massive scale.”
Romanian Ruling Coalition Faces Rift Over Higher Social Spending
Romanian Prime Minister Ilie Bolojan faced renewed pressure as the largest party in the ruling coalition blasted his leadership as “unacceptable” days before a critical budget vote.
Extreme Ocean Pressure Is Feeding Deep-Sea Life in a Way Scientists Never Expected
High pressure in the deep ocean may squeeze nutrients from sinking “marine snow,” feeding deep-sea microbes and altering how carbon moves through the ocean.
How do Micah Parsons’ and Maxx Crosby’s pressures really compare?
Since entering the league, Micah Parsons has outpaced Maxx Crosby by a decent margin
Why is there a heat wave in March? The science behind high pressure
Airline CEOs torch lawmakers for turning air travel into a ‘political football’
Airline leaders warned the DHS shutdown left TSA workers unpaid and travelers facing long lines as spring travel demand surged and pressure mounted on the aviation system.
‘How Low Can You Go?’ The Shifting Guidelines for Blood Pressure Control
The number doctors use to demarcate hypertension keeps going down, a trend applauded by many experts, who point to studies linking high blood pressure and dementia.
Dodgers’ Kike Hernandez Says Chasing Three-Peat is a ‘Privilege’
There's a lot of pressure on the Los Angeles Dodgers to win a third consecutive World Series in the 2026 season, but fan favorite Kike Hernandez isn't too bothered by it.
Judge quashes Justice Department subpoena of Federal Reserve
Judge James Boasberg said that a "mountain of evidence suggests" that the purpose of the subpoenas was simply to pressure the Fed to cut its key interest rate
Public Administration as Solution Science
The views expressed are those of the author and do not necessarily reflect the views of ASPA as an organization. By Naim KapucuMarch 13, 2026 Public administration is often described as the bridge between public goals and real results. When communities face complex problems such as public safety, health threats, climate risks, housing pressures or […]
Netanyahu sells regional change as hopes for Iran regime change fade
Israeli leaders are framing the bombing campaign as having transformed the Middle East in their favour as pressure to end the conflict builds.
How the rapid barometric pressure changes during erratic weather can wreak havoc on our health
Pittsburgh’s weather has been anything but predictable lately. Rapid swings in temperature, gusty winds and quick-moving storm systems have many...
Fed's favored inflation gauge remained stubbornly high in January as consumer price pressures persist
The Commerce Department on Friday released the January 2026 PCE inflation report, which showed the Federal Reserve's preferred inflation gauge remained stubbornly high for consumers.
The Memo: Political pressures grow on Trump over Iran
President Trump faces a plethora of political pressures stemming from his decision to attack Iran — and they are likely to escalate the longer the conflict goes on. In terms of domestic politics, t…
Under pressure from Trump, Republicans plan long talkathon on voting bill
Senate Republicans plan to launch a full debate next week on legislation to impose strict new proof-of-citizenship requirements
Republicans add to pressure on Senate majority leader after Trump voter ID bill call
Republicans join in with US president’s demand for John Thune to push through Save America act
Overwatch Director Jeff Kaplan Explains Why He Left Blizzard
He says the pressure kept ratcheting up to deliver more and more profits
Portland small businesses feel squeeze of costs and bureaucracy
Owners cite higher expenses, taxes and reputation concerns as key pressures.
Igor Tudor: Pressure grows as Antonin Kinsky experiment backfires and raises further questions over Spurs head coach
Why authentic leadership matters more than ever
Mission-driven leaders are facing unprecedented pressure as economic uncertainty, political polarization, rapid technological change and growing public scrutiny reshape how organizations operate, Harvard Business Review writes. A recent analysis highlights how these overlapping forces are turning routine decisions into tests of values, strategy and credibility. Research based on surveys and discussions with nonprofit and social […]
Justice Department’s brewing case against former CIA chief tests its efforts to prosecute Trump foes
Justice Department prosecutors leading an investigation into former CIA Director John Brennan are facing increasing pressure from top Justice officials to bring criminal charges against him after the department has flailed in trying to punish President Donald Trump’s perceived enemies, people briefed on the matter told CNN in recent days.
Mental health solutions for the digital age
Ask the digital natives of Gen Z about the source of their biggest mental health challenges, and most will say social media and AI.Several of the nearly 400 guests at the third annual Gen Z Wellness Summit, presented by the Friends of Semel Teen Advisory Council at UCLA on March 8, explicitly named the endless stream of content on their phones as serious stressors. “Everybody is addicted to (Tik Tok) as if they were addicted to substances,” said Jantin Asmar, 17, a senior at Virtual Academy in Antelope Valley. “We’re always chasing that dopamine. We’re expecting that dopamine rush and it’s really decaying our interactions with others.” High school student Jantin Asmar was among nearly 400 people who attended the third annual Gen Z Wellness Summit. (Photo by Sandy Cohen) Even young teens feel pressure to be on social media constantly, both to consume content and collect “likes,” said 13-year-olds Chloe and Sophia, both students at Brentwood School. “Everyone’s always on, and you miss stuff if you’re not on it,” Chloe said, adding that social media’s emphasis on appearances is leading to eating disorders: “That’s a big thing for our generation.”The incessant influx of images and updates creates expectations that “weigh teenagers down,” said Linda Kou, 16, a junior at San Gabriel High School.Even though digital spaces allow people to connect with others beyond their immediate surroundings, it doesn’t always translate to real-life community, said Kelah Morgan, 17, a senior at Animo South Los Angeles Charter High School. High school students Kelah Morgan, left, and Linda Kou, shared about the challenges presented by social media. (Photo by Sandy Cohen) “Even if you see people saying that they relate to you online, it might be hard to find people in your personal life who you see every day who you feel comfortable enough to say, ‘You see me online, but this is me in real life and what I’m actually going through,’” she said.Solutions for our digital timesThe Gen Z Wellness Summit was intentionally designed as a free, in-person gathering where young people interested in mental health from across the southland could meet in person. “Peer support is the most important element of maintaining our mental health in community,” said Helena Hansen, MD, PhD, director of UCLA’s Semel Institute for Neuroscience and Human Behavior.Keynote speakers at the summit addressed AI, social connection and self-empowerment, while breakout sessions included discussions about eating disorders, dating, substance use, phone detox and breathwork. Here are some of the day’s top takeaways:Beware of FOPO: Scott Barry Kaufman, PhD, a psychology professor at Columbia University, said that rather than FOMO, or fear of missing out, we ought to be more aware of FOPO: fear of people’s opinions. “Just think about how much your FOPO might be holding you back in your life,” Dr. Kaufman said. “And just that inner contemplation should be enough for you to change your life, because there’s so many things we don’t go after because we have debilitating FOPO.”We don’t need to feel like we’re the best – or what he called “narcissistic self-esteem” – but it’s helpful to acknowledge our own worth, recognize our good qualities and develop self-belief in the skills and talents we’ve cultivated. When we have that – dignity and self-respect, without needing everyone to like us – FOPO is less of a concern.Self-reflection is most effective in community: “When we try to self-reflect alone, we sometimes ruminate,” said Ira Bedzow, PhD, executive director of the Emory University Purpose Project. “But when we self-reflect with people that we trust … (it) allows us to hold ourselves accountable to different ways of seeing and different ways of hearing and different ways of being.”Opening up about our experiences and listening to others are skills we can develop, Dr. Bedzow said.He invited students to participate in what he called a “fishbowl exercise,” where four students sat in a small circle, surrounded by a dozen or so students forming a larger circle. Those in the inner circle answered such questions as: “What stops you from being you today?” and “What helps you feel most like you?”Within minutes, the group in the small circle (the fishbowl), were sharing intimately about their life challenges as those in the outer circle nodded in understanding.After the exercise, one participant said, “I felt like I wasn’t alone, that it wasn’t just me who feels that way.”Another remarked on how “personal” it felt to share face-to-face with others, even strangers.Don’t let AI crush your creativity: Theoretical neuroscientist Vivienne Ming, PhD, has been studying artificial intelligence for more than 20 years. And while she said “it’s reasonable to be concerned” about the fast-growing technology, it can also help humans become better problem-solvers when used strategically.“The smartest thing on the planet today are humans and machines working together creatively,” Dr. Ming said. “What gets more valuable in humans as machines get smarter? Our ability to explore the unknown.“Your unique voice is literally your value to the world … but most of us for most of our lives have been taught to not be unique,” she continued. “Be your own person. Celebrate being different. It is genuinely, measurably, truly valuable.”In a breakout session called “Phone Detox? IYKYK: Living Your Story IRL” led by Don Grant, PhD, students shared their frustrations with AI compromising academic work, art and creativity.“Art is a translation of human experience,” one participant said. “When people use AI, they diminish their own human experience.”Dr. Grant urged them, as “the last generation to remember a world before AI,” to remember the power of imagination and creativity – and to act on it.Remember that social media distorts perceptions: Stuart B. Murray, PhD, PsyD, who directs the Eating Disorders Program and Translational Research in Eating Disorders Program at UCLA, asked the students in his breakout session to take a spontaneous selfie and edit it to conform with society’s beauty standards. All 20 girls in the room immediately got to work, thickening their hair, slimming their faces, plumping their lips.“The pressure to look like what we present on social media can be crippling,” Dr. Murray said. “We now know that social media use is part of a causal pathway into an eating disorder.”Adolescents and young adults are most at risk of developing an eating disorder, he said, with one in three students on college campuses exhibiting clinically meaningful eating-disorder symptoms. More than 4 million people in California will have an eating disorder in their lifetime.Even for those who don’t develop anorexia or bulimia, the ubiquity of modified images online distorts what we consider normal, making us feel worse about ourselves. Remembering that, he and other speakers said, might inspire us to log off occasionally and spend time in the real world with people who love us as we are.
Watch Small Business Optimism Falls Again
For the second straight month, small-business optimism is falling. Sales expectations are weakening, and economic worries are rising. Xero CEO Sukhinder Singh Cassidy joined Bloomberg Open Interest to talk about the pressure points for small business and how owners are bracing for higher prices.
Stress of Pregnancy Complications Might Impact Future Heart Health, Study Says
By Dennis Thompson HealthDay ReporterTUESDAY, March 10, 2026 (HealthDay News) — Women who have pregnancy complications might face a higher risk of heart disease, a new study has concluded. The stress of these complications increase a woman’s risk of high blood pressure for years after they deliver,
How Can Character Count in Sports When Winning is Everything?
Kids sports has become a pressure cooker of flared tempers and bad behavior. How does one develop sportsmanship when winning has become so important?
Reeves to face MPs’ grilling over cost-of-living pressures
Chancellor to take Treasury questions amid market turbulence linked to Middle East conflict
Billionaire Czech Premier Shrugs Off Defense Calls to Focus on Health
As Russia’s war in Ukraine rages to the east and the US piles on pressure to spend more on the military, Czech Prime Minister Andrej Babis has been focusing on a very different agenda.
Starmer seeks to reassure public over cost of living as oil surges above $100 a barrel
The prime minister is facing pressure from unions and some backbenchers to prepare a support package as oil and gas prices threaten to push up inflation
Iran war sends shockwaves through African fuel market and economies
Rising global oil prices triggered by the Iran war are increasing economic pressures across Africa, where most countries rely heavily on imported petroleum products.
Trump Comes Under Pressure to Address Gas Prices, Iran War Strategy
Some Republicans warn that Americans have a limited tolerance for pain at the gasoline pump.
What intermittent fasting really does for your body and brain
Fasting has been shown to reduce blood pressure, improve cognition, and even reverse chronic disease. But experts say the benefits may not apply to everyone.
NY businesses pressured by high costs. Could Albany help?
Affordability continues to be a main concern for businesses statewide, a recent survey released by The Business Council of New York State reveals.
UCLA beats Ohio State, advances to Big Ten tournament title game
UCLA center Lauren Betts and the Bruins tightened their defensive pressure during a 72-62 victory over Ohio State, extending their win streak to 24 games.
As WA grocery stores shutter, lawmakers struggle to respond
Four of five bills in the Legislature meant to prevent grocery closures stalled out under industry pressure, in a short session dominated by a wealth tax debate.
Dane County businesses struggle under Trump tariff burden
MIDDLETON, Wis. — Small businesses across Dane County are grappling with mounting financial pressure from federal tariffs, with many saying they lack the resources to challenge the policies in court
Who are the Kurds and what role could they play in the war with Iran?
The involvement of the Kurds could pressure Iranian defenses and pull Iraq deeper into war.
‘Firing her is not enough’: Democrats celebrate Kristi Noem departure but say she must be ‘held accountable’
Gavin Newsom among those celebrating Noem’s ousting, as Democrats warn pressure must be kept up against ICE
Abry Brothers has been keeping it on the level for 7 generations, shoring up a sinking city
Abry Bros.has been shoring and leveling structures in New Orleans for nearly 200 years. New cost pressures and insurance regulations are making it harder than ever for the sixth- and seventh-generation owners.
Friday briefing: Can the politics of cruelty around asylum help Labour in the polls?
In today’s newsletter: Labour’s new asylum framework marks a decisive shift in how the UK treats people granted protection and exposes tensions between electoral strategy, public service pressures and the party’s historic commitments to human rights
Colorado Gov. Polis considers releasing Tina Peters from prison amid Trump pressure
Colorado's Democratic governor, facing a pressure campaign from President Donald Trump, is signaling his openness to granting clemency to a former county clerk who was convicted in a scheme that attempted to find proof of fraud in the 2020 presidential election.
How Kristi Noem's fate was sealed: From the Politics Desk
Plus, Rep. Tony Gonzales faces pressure on Capitol Hill ahead of his runoff.
Justice Dept., Under Pressure From Trump, Fails to Build Autopen Case Against Biden
Prosecutors in the U.S. attorney’s office in Washington were unable to build a case, underscoring the department’s increasing inability to follow through on the president’s desire to indict his rivals.
Pressure points: Balancing clinical and financial priorities in health care | Harvard T.H. Chan School of Public Health
As financial pressures intensify across health care, leaders face difficult choices that test their ability to protect clinical excellence while sustaining their organizations. Join leading experts for a candid conversation about navigating the tensions between clinical and financial priorities—and the skills, strategies, and innovations needed to lead effectively through these competing demands.
March Madness bubble watch: Pressure builds in final week of regular season
There's not many chances left for March Madness hopefuls before conference tournaments decide their fate.
Manchester City v Nottingham Forest: Key stats and talking points
Manchester City go in search of a seventh consecutive win in all competitions, hosting relegation-threatened Nottingham Forest. BBC Sport examines some of the key themes before Wednesday's match (19:30 GMT). Manchester City were without their top scorer for the visit to Leeds – the city where the Norwegian was born – but nonetheless recorded another important victory to keep the pressure on leaders Arsenal.
'In a bit of chaos': FDA watchers warn about agency hemorrhaging staff and the risk to America's health
Scientific, political pressures colliding at FDA, delaying rare disease treatment for patients who have few or no options, experts said at CNBC Cures Summit.
Alan Cumming, Bowen Yang Help Launch Necessary Foundation to Support LGBTQ Filmmakers
"There is, in this moment, enormous political pressure to delete queer people from American media, and that includes young filmmakers who are being shut out of the industry,” said executive director A...
Common Arthritis Drug Found To Lower Blood Pressure and Boost Heart Health
A widely used treatment for rheumatoid arthritis may offer an unexpected cardiovascular benefit. Methotrexate has been a staple treatment for rheumatoid arthritis for decades, valued for its ability to calm an overactive immune system and reduce painful joint inflammation. Now, researchers say it m
Following This 3-Hour Rule Before Bed Could Support Healthy Blood Pressure and Blood Sugar
New research links not eating for a few hours before bed—and 13 to 16 hours overnight—with better heart health and blood sugar markers.
We're initiating a position in this health-care stock with a $260 price target
This backbone of the U.S. health-care industry generates about 99% of its revenue domestically, insulating it from overseas pressure.
Iran crisis puts UK leader Keir Starmer in a new political bind
The U.K. prime minister is under pressure from all sides over his stance on U.S. and Israeli strikes on Iran.
If Iran Strikes Backfire, Voters Will Know Who’s to Blame
President Donald Trump begins his conflict with Iran on a narrow ledge in public opinion. So long as the mission’s costs to America remain small, he’s unlikely to face insurmountable political pressure to end it. But he starts the war extraordinarily vulnerable to backlash if things go wrong.
Six Flags Entertainment (FUN) Is Down 6.6% After Deep 2025 Losses And Investor Exit Has The Bull Case Changed?
In February 2026, Six Flags Entertainment reported its fourth-quarter and full-year 2025 results, showing quarterly revenue of US$116.97 million and a quarterly net loss of US$92.38 million, while full-year revenue reached US$3.10 billion with a much larger full-year net loss of US$1.60 billion. The earnings release, combined with Broyhill Asset Management’s exit after citing integration challenges, weather exposure, pressure on lower-income guests, and leadership changes, has sharpened...
CHS Marine Biology Club Raises Funds to Support Science—And Send a Message
"If people actually understood the importance of marine research, they would participate more in our cause to fund it, or at least encourage the government to begin funding it again with public pressure." — CHS Marine Biology Club President Nicola Suraci
China’s Economic Involution: State and Business Strategies
China’s economic involution, characterized by cutthroat, race-to-the-bottom competition, is a symptom rooted in its political and fiscal structure. During the recent economic downturn, the central government, local governments, and businesses entered a self-reinforcing cycle. The central growth targets and debt-reduction pressures pushed local governments to expand investment in state-favored industries, creating low-profit competition and oversupply. The declining revenues further reduced deman