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Mercury’s momentum continues to grow after blowout win over Storm
PHOENIX — If there was any indication the Phoenix Mercury are turning their season around, Thursday’s win was it. Mercury associate head coach Kristi Toliver laughs with an official during a game against the Storm at the Mortgage Matchup Center in Phoenix, on July 2, 2026.
Europe’s Health Systems Face a Heat Test
New WHO guidance highlights how extreme heat is straining hospitals, with practical measures now shaping safer care environments across Europe.
AMERICA AT 250: COMPETING CELEBRATIONS REFLECT NATIONAL POLARIZATION, SAYS SMU POLITICS EXPERT
DALLAS (SMU) – As the nation marks its 250th anniversary with separate celebrations in Washington, D.C., and Los Angeles, SMU political scientist Matthew Wilson says the split reflects a deeper reality about modern America: the absence of a shared national narrative. Wilson argues that what should have been a unifying moment of national pride has instead become a symbol of the country's growing political polarization, with rival groups promoting fundamentally different visions of Amer
Austria's Best Moments 2026 FIFA World Cup™ 🇦🇹
Check out Austria's 2026 FIFA World Cup™ best moments.
Ashley Tisdale putting her real-life drama to work in comedy series “Toxic Moms”
The Disney Channel alum wrote a personal essay about her mom group drama for "The Cut" earlier this year.
Nike Running's a $5 Billion Business: What's Next?
Nike Running added $1 billion over the last five quarter to become a $5 billion business, leading Nike's turnaround. Can that momentum continue?
Rhode Island Marijuana Officials Ask Judge To Remove Block On Business Licenses Now That Rules Targeted By Lawsuit Have Changed
“We’re hopeful that once we get the go-ahead with the appropriate people that we can get the process moving again.” By Christopher Shea, Rhode Island Current Now that Rhode Island has eliminated the residency requirement for recreational pot shop owners, the state’s Cannabis Control Commission is asking a federal judge to undo the court order […]
Premier Lacrosse League raises $100 million as sport gears up for ‘biggest moment’ in its history
Another big valuation moment for an up-and-coming sports league.
MOMENT OF SCIENCE: Two planets lighter than cotton candy
Astronomers have discovered two planets the size of Jupiter, but get this: their densities are so low, they’re estimated to be lighter than cotton candy!
9 Founders Who Turned Their Worst Moment Into A Business
Nine founders faced rock bottom, a death, a diagnosis, a war, a collapse, and built a business out of it. How they found strength when it felt furthest away.
Bonus 236: A Term of Self-Inflicted Wounds
Within minutes of the Supreme Court handing down the birthright citizenship ruling on Tuesday and rising for its summer recess, its defenders were pointing to that decision (alongside the late-arriving mail-in ballots ruling on Monday and the tariffs ruling from February) as decisive proof that the Court really is “above politics,” and that criticisms of the justices for behaving more like politicians in robes than like judges are thus unfair. For a particularly thoughtful version of this claim, see Professor Will Baude’s opening response to the latest New York Times written roundtable about the Court with Baude, Professor Kate Shaw, and me. In that roundtable, I already offered one of the two major arguments against this thesis—that it’s an assessment of the numerator without regard to the denominator, and that a full account of the Court’s behavior throughout OT2025 suggests that the Court behaved even more politically during the current term than during even the previous (highly politicized) one. Just to take one of many data points, last term (OT2024), there were six rulings in argued cases in which all six Republican-appointed justices were in the majority and all three of the Democratic appointees were in dissent (along with a slew of such rulings on the emergency docket). This term, there were … 13. (Along with two 6-3 summary reversals and 10 rulings on the emergency docket from which the three Democratic appointees all dissented.) Today’s bonus issue addresses the flip side of that coin. In particular, below the fold, I identify four different moments in which the justices could have acted in ways to specifically defuse charges of political behavior—and opted instead to lean all the way in. As much as end-of-term narratives focus on what the Court did, and on the takeaways from individual rulings, consider today’s post an attempt to identify opportunities that the Court missed, as well. At least in the examples discussed below, by opting for the outcome that made the Court look more transparently political, the Court inflicted a series of (unnecessary) credibility wounds on itself. For those who aren’t paid subscribers, we’ll be back Monday with our regular coverage of the Court. For those who are, please read on.
'The old politics are gone': Steve Bannon on the democratic socialist wave
Trump's former White House chief strategist argues the U.S. is in a transformational political moment — and leadership in both parties are way behind.
Takeaways from a divisive Supreme Court term that expanded Trump’s power
After berating the Supreme Court for much of the year — while simultaneously inviting some of the justices over to the White House for dinner — President Donald Trump’s final assessment of the court’s momentous term this week felt something like a ceasefire.
Senegal's Best Moments 2026 FIFA World Cup™ 🇸🇳
Check out Senegal's 2026 FIFA World Cup™ best moments.
Bickley: They're no longer the mom-and-pop Lakers
The Lakers have changed. They are cunning and coherent. They are no longer a mom-and-pop shop awkwardly in charge of an iconic brand. Welcome to our latest
Canes football remains on a recruiting surge. And basketball team adds a center
UM football, basketball teams keep up momentum in recruiting.
10 reasons Wimbledon still feels like sports’ greatest summer ritual
Every summer, the tennis world turns its attention to the grass courts of the All England Lawn Tennis and Croquet Club in London. The 2026 Championships, Wimbledon has already produced memorable moments in the first round, with established champions, emotional…
The moment Anthropic convinced me it’s serious about science
AI Prognosis: The release of Claude Science suggests big model makers are getting serious about real science, and not just flashy problems.
Should Value Investors Buy Accel Entertainment (ACEL) Stock?
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
Seth Rogen shares awkward moment with 'Lion King' collaborator Pharrell Williams at dinner party (exclusive)
'The Invite' star Seth Rogen is recounting an incident where Pharrell Williams confronted him at a dinner party over Rogen's 'Lion King' interviews.
Seth Rogen shares awkward moment with “Lion King” collaborator Pharrell Williams at dinner party (exclusive)
The music superstar didn't appreciate Rogen's interviews.
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
America 250 road trip: A new mom discovers the oldest secret in sports
What makes a sport American? Fans leave clues at a Florida pickleball party, a Charleston crawfish-eating contest and Vince Lombardi's grave.
Americans step out for their nation's 250th in a proud moment sown with division and doubt
America has come to a landmark moment of pride and patriotism — and a time of division and doubt
Ecuador's Best Moments 2026 FIFA World Cup™ 🇪🇨
Check out Ecuador's 2026 FIFA World Cup™ best moments.
How Elite Sports Coaches Make High-Pressure Decisions
Drawing on interviews with 11 elite coaches across major U.S., European, Australian, and New Zealand professional sports leagues, the authors show that high-pressure decisions aren’t a single “formula” but a set of practices that unfold before, during, and after pivotal moments—and translate directly to business leadership. Top coaches combine disciplined preparation with emotional control and social awareness during crunch time and accountability and continual system improvement after the fact.
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
WATCH: Angel mom turns tables on sanctuary politicians with basic question about their priorities
Jessica Gorman told lawmakers her daughter Sheridan “was not a talking point" as she accused sanctuary city leaders of failing to protect American citizens.
Could a schism over Israel scuttle Democrats’ midterm momentum?
A new crop of candidates is rattling Democratic leadership with their willingness to criticize what was once a pillar of party unity
Tennessee transfer infielder Manny Marin commits to Arkansas
Tennessee transfer infielder Manny Marin has committed to Arkansas via the NCAA Transfer Portal. The former Volunteers star made the announcement via his Instagram page. — This story is developing and will be updated. Check back momentarily.
Are Investors Undervaluing Inspired Entertainment (INSE) Right Now?
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
Premier Lacrosse League lands $100 million to chase Olympic moment
The funding comes at a crucial period of preparation for PLL, as it looks to capitalize on lacrosse being a part of the 2028 Summer Olympics.
Netherlands' Best Moments 2026 FIFA World Cup™ 🇳🇱
Check out Netherlands' 2026 FIFA World Cup™ best moments.
Stephen Amell is now 'best friends' with soccer star Neymar after replying to years-old DM on live TV
Stephen Amell tells EW about the nail-biting moment James Corden took control of his phone on a live Fox Sports broadcast to respond to a years-old DM from Brazilian soccer star Neymar, with whom he's now 'best friends.'
Browns QB Shedeur Sanders Gets Bad News on Future
The Cleveland Browns’ quarterback competition remains open heading into training camp, but the momentum appears to be favoring Deshaun Watson, not Shedeur Sanders. The post Browns QB Shedeur Sanders Gets Bad News on Future appeared first on HEAVY.
Germany's Best Moments 2026 FIFA World Cup™ 🇩🇪
Check out Germany's 2026 FIFA World Cup™ best moments.
Olivia Wilde says Walton Goggins 'saved my life' after horse accident
Olivia Wilde recalled the moment her "Cowboys & Aliens" costar Walton Goggins "saved my life" after a horse accident on the set of the 2011 sci-fi Western. "I've ridden horses
A Defining Moment in Chicago Sports: Chicago Fire FC Acquires Global Football Icon Robert Lewandowski
Poland’s all-time leading goal scorer joins the Fire from FC Barcelona with more than 700 goals for club and country
LDI and American Healthcare
A news feature from the Pennsylvania Gazette reflects on LDI’s history and leaders, and how they are currently meeting the federal health policy moment.
2026 BET Awards: The 5 biggest moments of celebration and remembrance
Family and sisterhood were on display at the 2026 BET Awards at the Peacock Theater with wins for Cardi B, SZA and Doechii, and tributes to D'Angelo and Lauryn Hill.
Wisconsin moms on Medicaid now get 12 months of coverage
Wisconsin’s new law extends mothers’ Medicaid coverage for a full year after birth. Medical experts say it will save lives.
🎧 When belief returned: Episode five of new Coventry documentary
The relegation from League One to the bottom tier of English football starts episode five of Back Where We Belong. Under Mark Robins, Coventry City found their identity and stability on the pitch, with fans finding joy in small and shared moments. With Wasps still owning the Ricoh Arena, the Sky Blues were forced to ground-share with Birmingham City at St Andrew's.
Just hopes agent is 'busy' after World Cup impact
Elijah Just hopes his agent is "busy at the moment" as the New Zealand midfielder hinted at a possible summer exit from Motherwell after impressing at the World Cup. Just only joined Motherwell from Danish club Horsens a year ago and is under contract until next summer, with the Scottish Premiership club having an option of extending that by a further year. "The World Cup has given me added belief and also motivation to keep pushing," Just told the NZ Herald.
Eagles Fifth Round Pick Being Viewed as Next Brock Purdy
If there's one guy I trust around the NFL, it's Howie Roseman. Roseman, who has continued to prove that he can find talent at a very high level at any given moment, is hopeful that he did so in the NFL Draft once again with his fifth-round pick of Cole Payton.
I'm a stay-at-home mom of 2. My 4 side gigs help me pay off debt.
Lana Ng left her marketing job in 2023 to take care of her children. Now, her four side gigs help her not lose herself in motherhood.
Mets drop tough one in series finale
A.J. Ewing nearly had his Mets moment, but a Kyle Schwarber home run ruined the fun on Sunday afternoon.
Science confirms this viral ‘secret’ praise parenting technique is certifiably genius
A mom's viral technique of praising her daughter within earshot has over a million likes, and psychologists say it really works.
France, Argentina top World Cup odds; U.S. puts sportsbooks at risk
Star-powered France and Argentina top the odds board to win the World Cup as the tournament moves into the knockout stage, while the United States' positive momentum will have sportsbooks sweating more with each game it wins.
‘Odyssey’ fever grips the Classics world
Fans of the ancient world are seizing their moment with the release of this summer’s blockbuster.
Hurricanes Acquire Rights To Top Offensive Blueliner John Carlson
Carolina secures exclusive negotiating rights with the veteran power-play specialist as they look to bolster their defensive core before the free agency market opens.
You’ve never seen this before: the shocking moment the sound barrier breaks - Futura-Sciences
The XB-1 is a critical stepping stone toward commercial supersonic travel, representing the first civil designed aircraft to break the sound barrier since the Concorde retired. To verify the aircraft’s aerodynamic performance during its supersonic transition, NASA deployed an advanced optical technology called schlieren imaging to make the invisible forces...
Burcum: Sanford Health got what it wanted. Now comes the moment of truth.
From columnist Jill Burcum: The South Dakota health system has spent a decade trying to crack the Twin Cities health care market. With the North Memorial deal, it now has a chance to prove itself.
Dear Abby | Mom's rekindling with abusive father feels like a betrayal
Dear Abby: I am estranged from my father and have been since I was 12. (I'm currently 26.) He was emotionally, psychologically and physically abusive to me, and cutting ties
NWSL team fuels push for more women’s sports
NWSL team adds momentum to women’s sports push
NWSL team fuels push for more women’s sports
NWSL team adds momentum to women’s sports push
Tolle tries to tackle Yankees in Friday night clash
Can the momentum actually be kept up from last night’s win?
Moment of Science: Music and Color
Dr. Stefan Wienzierl at TU Berlin studies how the architecture of a classroom or concert hall can impact the quality of music or speech.
We cut MBA prices because America needs more professionals, not fewer
America is running short on educated workers at the exact moment when they matter the most.
MOMENT OF SCIENCE: How music can be interpreted differently
Music is a universal language, although how we perceive it can change from person to person.
Big Ten women’s sports are having a moment. What is the league doing to capitalize?
In the two years since Caitlin Clark left for the WNBA, the Big Ten has worked to keep its momentum.
2026 NHL Mock Draft
Ahead of tonight’s NHL draft, let’s take a stab at how the first round could play out tonight. First, a moment of silence for our near miss last year – when we tried to predict that Kyle Dubas would go ‘off the board’ with a high pick on a WHL center that no one saw […]
Sharonville mom raising money for UC Health's ICU patient program after she nearly died
It's been a year since a Sharonville mom suffered a medical emergency days after giving birth to her second child.
Baxter Health Heart and Vascular Clinic Welcomes Brandi Watson, APRN
Baxter Health is proud to welcome Brandi Watson, APRN, to the Baxter Health Heart and Vascular Clinic. Watson joined the team on May 15 and is currently accepting new patients. Watson brings more than 25 years of experience caring for some of the most critically ill patients. Much of her career has been spent in intensive care settings, where she learned to make fast, high-stakes decisions for patients whose lives depended on getting the right care at the right moment. That kind of experience, which is gained through years at the bedside, is exactly what heart and vascular patients need from a provider.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Entrepreneurs pitched business ideas to Yahoo Finance
Yahoo Finance Executive Editor Brian Sozzi is on the hunt for the next big business breakthrough. Check out the absolute best pitches and standout moments from the innovators making waves at Cannes Lions.
Emily Ratajkowski says she rejects the label 'divorced single mom'
Emily Ratajkowski is opening up about resenting the label "divorced single mom" following her split from ex-husband Sebastian Bear-McClard.
Google Finance gets a dedicated app for Android
Users will be able to access their watchlists, real-time market data, live financial news, and Google's AI-powered "Key Moments" feature, which explains why stocks moved.
Embodying the Moment: Paloma Elsesser On Beauty, Bodies and Business
The model and muse explained her supermodel origin story and her plans for her next act onstage at The Business of Beauty Global Forum.
Windcrest welcomes new restaurants, businesses as city works to close revenue gap left by Rackspace
Windcrest leaders say the city is gaining momentum in its effort to attract new businesses and rebuild sales revenue after Rackspace left behind a more than a $1 million gap in the city’s annual budget.
How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
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